Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	VIT	VWA5B1 ITIH4	7.97e-04	10	80	2	PS51468
Domain	VIT	VWA5B1 ITIH4	7.97e-04	10	80	2	IPR013694
Domain	CBS	CNNM1 CLCN7	2.09e-03	16	80	2	SM00116
Domain	Sulfatase_CS	ARSB GNS	2.09e-03	16	80	2	IPR024607
Domain	SULFATASE_1	ARSB GNS	2.36e-03	17	80	2	PS00523
Domain	SULFATASE_2	ARSB GNS	2.36e-03	17	80	2	PS00149
Domain	Sulfatase	ARSB GNS	2.65e-03	18	80	2	PF00884
Domain	Sulfatase_N	ARSB GNS	2.65e-03	18	80	2	IPR000917
Domain	PDZ	SCRIB RIMS2 TAMALIN RGS3	3.16e-03	141	80	4	PF00595
Domain	CBS_dom	CNNM1 CLCN7	3.27e-03	20	80	2	IPR000644
Domain	CBS	CNNM1 CLCN7	3.27e-03	20	80	2	PF00571
Domain	CBS	CNNM1 CLCN7	3.27e-03	20	80	2	PS51371
Domain	PDZ	SCRIB RIMS2 TAMALIN RGS3	3.76e-03	148	80	4	SM00228
Domain	-	SCRIB RIMS2 TAMALIN RGS3	3.94e-03	150	80	4	2.30.42.10
Domain	-	RGS3 AXIN1	3.96e-03	22	80	2	1.10.196.10
Domain	RGS_subdom1	RGS3 AXIN1	3.96e-03	22	80	2	IPR024066
Domain	PDZ	SCRIB RIMS2 TAMALIN RGS3	4.03e-03	151	80	4	PS50106
Domain	PDZ	SCRIB RIMS2 TAMALIN RGS3	4.13e-03	152	80	4	IPR001478
Domain	WGR_domain	PARP10 LAMA2	4.70e-03	24	80	2	IPR008893
Domain	EGF_1	ZAN TIE1 LAMA2 ASTN2 LTBP4	4.77e-03	255	80	5	PS00022
Domain	EGF_2	ZAN TIE1 LAMA2 ASTN2 LTBP4	5.61e-03	265	80	5	PS01186
Domain	Alkaline_phosphatase_core	ARSB GNS	7.77e-03	31	80	2	IPR017850
Domain	Alkaline_Pase-like_a/b/a	ARSB GNS	7.77e-03	31	80	2	IPR017849
Domain	-	ARSB GNS	7.77e-03	31	80	2	3.40.720.10
Pubmed	Aplp1 interacts with Lag3 to facilitate transmission of pathologic α-synuclein.	LAG3 APLP1	5.90e-06	2	85	2	38821932
Pubmed	PDZ-scaffold protein, Tamalin promotes dendritic outgrowth and arborization in rat hippocampal neuron.	PSD TAMALIN	5.90e-06	2	85	2	22569042
Pubmed	Genetic regulation of murine hepatic arylsulfatase B activity during development.	ARSB BLOC1S3	5.90e-06	2	85	2	7069188
Pubmed	Mechanistic basis for receptor-mediated pathological α-synuclein fibril cell-to-cell transmission in Parkinson's disease.	LAG3 APLP1	5.90e-06	2	85	2	34172566
Pubmed	Large-scale concatenation cDNA sequencing.	PTOV1 FAM120A LRP10 NUP133 RIMS2 SEZ6L2 REEP2 RGS3 KIFC2	1.06e-05	568	85	9	9110174
Pubmed	A "double adaptor" method for improved shotgun library construction.	PTOV1 FAM120A LRP10 NUP133 RIMS2 SEZ6L2 REEP2 RGS3 KIFC2	1.15e-05	574	85	9	8619474
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	ISLR2 ZNF469 SOWAHA ARSB FAM120A WIZ PSD RASAL3 PRSS56 SCRIB LTBP4 ITIH4	1.71e-05	1116	85	12	31753913
Pubmed	A probability-based approach for high-throughput protein phosphorylation analysis and site localization.	FAM120A EIF4G1 NUP133 SCRIB ANKLE2 ZXDA HNRNPK RAVER1	3.29e-05	503	85	8	16964243
Pubmed	Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16.	METRN CLCN7 NME4 AXIN1	3.36e-05	74	85	4	11157797
Pubmed	Merosin-deficient congenital muscular dystrophy with mental retardation and cerebellar cysts, unlinked to the LAMA2, FCMD, MEB and CMD1B loci, in three Tunisian patients.	LAMA2 POMGNT1	3.53e-05	4	85	2	12467726
Pubmed	BACE1-cleavage of Sez6 and Sez6L is elevated in Niemann-Pick type C disease mouse brains.	BACE1 SEZ6L2	3.53e-05	4	85	2	29979789
Pubmed	RC3H1 post-transcriptionally regulates A20 mRNA and modulates the activity of the IKK/NF-κB pathway.	WIZ PRDX4 EIF4G1 HNRNPK RAVER1	4.18e-05	156	85	5	26170170
Pubmed	RNF43 inhibits WNT5A-driven signaling and suppresses melanoma invasion and resistance to the targeted therapy.	ATXN2 PRDX4 NUP133 SCRIB ANKLE2 AXIN1	4.69e-05	263	85	6	34702444
Pubmed	Systematic protein-protein interaction mapping for clinically relevant human GPCRs.	PTOV1 PTGES2 SPG7 METRN PKD1 BACE1 ASTN2 SCRIB HNRNPK	5.25e-05	697	85	9	28298427
Pubmed	Multiple loci influence erythrocyte phenotypes in the CHARGE Consortium.	ZAN ATXN2 TFR2	8.71e-05	35	85	3	19862010
Pubmed	Trafficking of TRPP2 by PACS proteins represents a novel mechanism of ion channel regulation.	CLCN7 PKD1	8.80e-05	6	85	2	15692563
Pubmed	Absence of post-phosphoryl modification in dystroglycanopathy mouse models and wild-type tissues expressing non-laminin binding form of α-dystroglycan.	LAMA2 POMGNT1	8.80e-05	6	85	2	22270369
Pubmed	Cleavage of amyloid-beta precursor protein and amyloid-beta precursor-like protein by BACE 1.	BACE1 APLP1	8.80e-05	6	85	2	14699153
Pubmed	The Stat3/5 locus encodes novel endoplasmic reticulum and helicase-like proteins that are preferentially expressed in normal and neoplastic mammary tissue.	HCRT KCNH4	1.23e-04	7	85	2	11735219
Pubmed	Rebuilding essential active zone functions within a synapse.	CACNA1B RIMS2	1.23e-04	7	85	2	35176221
Pubmed	TGIF governs a feed-forward network that empowers Wnt signaling to drive mammary tumorigenesis.	TGIF1 AXIN1	1.23e-04	7	85	2	25873176
Pubmed	Genomic analysis of mouse retinal development.	PTOV1 ISLR2 FAM120A SPG7 METRN PKD1 FGF3 CROCC SEZ6L2 AXIN1	1.73e-04	1006	85	10	15226823
Pubmed	The SH2/SH3 adaptor Grb4 transduces B-ephrin reverse signals.	HNRNPK AXIN1	2.10e-04	9	85	2	11557983
Pubmed	Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.	CNNM1 WIZ CLCN7 ATXN2 TMEM160 NUP133 C1QBP SCRIB ANKLE2 RAVER1	2.41e-04	1049	85	10	27880917
Pubmed	The deubiquitinase OTUD1 regulates immunoglobulin production and proteasome inhibitor sensitivity in multiple myeloma.	PRDX4 C1QBP	2.62e-04	10	85	2	36357400
Pubmed	T-STAR/ETOILE: a novel relative of SAM68 that interacts with an RNA-binding protein implicated in spermatogenesis.	KIFC2 HNRNPK	2.62e-04	10	85	2	10332027
Pubmed	A High-Density Human Mitochondrial Proximity Interaction Network.	PTGES2 FAM120A WIZ ATXN2 TMEM160 NUP133 C1QBP NME4 ANKLE2 HNRNPK SHISA8 RAVER1	2.76e-04	1496	85	12	32877691
Pubmed	Regulation of alternative splicing by SRrp86 and its interacting proteins.	C1QBP TARBP1 HNRNPK	3.75e-04	57	85	3	14559993
Pubmed	Novel features of boundary cap cells revealed by the analysis of newly identified molecular markers.	METRN PRSS56 RGS3	3.94e-04	58	85	3	19243017
Pubmed	Arginine methylation and ubiquitylation crosstalk controls DNA end-resection and homologous recombination repair.	FAM120A WIZ ATXN2 PRDX4 EIF4G1 C1QBP HNRNPK	4.10e-04	551	85	7	34728620
Pubmed	Gene expression in the developing mouse retina by EST sequencing and microarray analysis.	WIZ CMPK2 FGF3 AXIN1	4.17e-04	142	85	4	11812828
Pubmed	TNIP2 is a Hub Protein in the NF-κB Network with Both Protein and RNA Mediated Interactions.	PTOV1 ATXN2 PRDX4 EIF4G1 C1QBP ANKLE2 LTBP4 BBC3 AXIN1	4.23e-04	922	85	9	27609421
Pubmed	SND1 binds SARS-CoV-2 negative-sense RNA and promotes viral RNA synthesis through NSP9.	FAM120A ATXN2 EIF4G1 HNRNPK RAVER1	4.37e-04	258	85	5	37794589
Pubmed	Protein interactome reveals converging molecular pathways among autism disorders.	ARX NUP133 C1QBP POMGNT1 LTBP4 HNRNPK AXIN1	4.51e-04	560	85	7	21653829
Pubmed	Expression patterns of sulfatase genes in the developing mouse embryo.	ARSB GNS	4.52e-04	13	85	2	20503373
Pubmed	Comparative analysis of the gene-dense ACHE/TFR2 region on human chromosome 7q22 with the orthologous region on mouse chromosome 5.	ZAN TFR2	4.52e-04	13	85	2	11239002
Pubmed	Large-scale sequencing of two regions in human chromosome 7q22: analysis of 650 kb of genomic sequence around the EPO and CUTL1 loci reveals 17 genes.	ZAN TFR2	5.27e-04	14	85	2	9799793
Pubmed	mTORC1 activity regulates post-translational modifications of glycine decarboxylase to modulate glycine metabolism and tumorigenesis.	FAM120A ATXN2 EIF4G1 SCRIB HNRNPK	5.74e-04	274	85	5	34244482
Pubmed	PDZ-Containing Proteins Targeted by the ACE2 Receptor.	SCRIB TAMALIN	6.07e-04	15	85	2	34835087
Pubmed	Comprehensive Protein Interactome Analysis of a Key RNA Helicase: Detection of Novel Stress Granule Proteins.	ATXN2 C1QBP	6.07e-04	15	85	2	26184334
Pubmed	A Noncanonical Role of Fructose-1, 6-Bisphosphatase 1 Is Essential for Inhibition of Notch1 in Breast Cancer.	FAM120A EIF4G1 C1QBP NME4 HNRNPK	6.96e-04	286	85	5	32041737
Pubmed	Targeting SKA3 suppresses the proliferation and chemoresistance of laryngeal squamous cell carcinoma via impairing PLK1-AKT axis-mediated glycolysis.	FAM120A PKD1 NUP133	7.44e-04	72	85	3	33106477
Pubmed	Congenital Muscular Dystrophy Overview – RETIRED CHAPTER, FOR HISTORICAL REFERENCE ONLY	LAMA2 POMGNT1	7.84e-04	17	85	2	20301468
Pubmed	Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors.	PARP10 ARSB ATXN2 PRDX4 C1QBP POMGNT1 NME4 ANKLE2 HNRNPK AXIN1 RAVER1	8.06e-04	1451	85	11	30550785
Pubmed	Comparative Application of BioID and TurboID for Protein-Proximity Biotinylation.	PTGES2 PRR14 CLCN7 ATXN2 NUP133 RAVER1	9.08e-04	457	85	6	32344865
Pubmed	Loss of Wiz Function Affects Methylation Pattern in Palate Development and Leads to Cleft Palate.	WIZ AXIN1	9.83e-04	19	85	2	34150743
Pubmed	αE-catenin inhibits YAP/TAZ activity to regulate signalling centre formation during tooth development.	FGF3 SCRIB	9.83e-04	19	85	2	27405641
Pubmed	High-sensitivity profiling of SARS-CoV-2 noncoding region-host protein interactome reveals the potential regulatory role of negative-sense viral RNA.	POLR3D FAM120A PRDX4 EIF4G1 C1QBP HNRNPK	1.04e-03	469	85	6	37314180
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	PTGES2 FAM120A WIZ EIF4G1 PKD1 ASTN2 DNAAF9 SCRIB TARBP1 HNRNPK	1.16e-03	1285	85	10	35914814
Pubmed	AMPK, a Regulator of Metabolism and Autophagy, Is Activated by Lysosomal Damage via a Novel Galectin-Directed Ubiquitin Signal Transduction System.	PRDX4 NUP133 C1QBP SCRIB HNRNPK AXIN1	1.22e-03	484	85	6	31995728
Pubmed	Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening.	PKD1 EXTL1 RIMS2 KIFC2 GNS	1.30e-03	329	85	5	17474147
Pubmed	Fgfr1 regulates patterning of the pharyngeal region.	TIE1 FGF3	1.32e-03	22	85	2	12514106
Pubmed	Impairment of Wnt11 function leads to kidney tubular abnormalities and secondary glomerular cystogenesis.	PKD1 SCRIB	1.32e-03	22	85	2	27582005
Pubmed	Interaction of antiproliferative protein Tob with the CCR4-NOT deadenylase complex.	HNRNPK RAVER1	1.32e-03	22	85	2	18377426
Pubmed	The sequence and analysis of duplication-rich human chromosome 16.	METRN NME4 AXIN1	1.42e-03	90	85	3	15616553
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	ZNF48 WIZ SPG7 CLCN7 EIF4G1 PKD1 POMGNT1 LTBP4 KIFC2	1.51e-03	1105	85	9	35748872
Pubmed	RSPO-LGR4 functions via IQGAP1 to potentiate Wnt signaling.	EIF4G1 FNBP4 SCRIB HNRNPK	1.55e-03	202	85	4	24639526
Pubmed	Proteomic analysis of the cellular responses induced in uninfected immune cells by cell-expressed X4 HIV-1 envelope.	PRDX4 C1QBP	1.57e-03	24	85	2	17676665
Pubmed	RUFY1 binds Arl8b and mediates endosome-to-TGN CI-M6PR retrieval for cargo sorting to lysosomes.	PRDX4 C1QBP SCRIB HNRNPK RAVER1	1.58e-03	344	85	5	36282215
Pubmed	A genomic atlas of mouse hypothalamic development.	ISLR2 ARX HCRT AXIN1	1.64e-03	205	85	4	20436479
Pubmed	A directed protein interaction network for investigating intracellular signal transduction.	TGIF1 PRR14 POLR3D WIZ SPG7 PRDX4 EIF4G1 APLP1 KIFC2	1.70e-03	1124	85	9	21900206
Pubmed	An interaction between OTULIN and SCRIB uncovers roles for linear ubiquitination in planar cell polarity.	SCRIB AXIN1	1.71e-03	25	85	2	37589075
Pubmed	Gse1, a component of the CoREST complex, is required for placenta development in the mouse.	ISLR2 SCRIB	1.71e-03	25	85	2	37019373
Pubmed	Tubby family proteins are adapters for ciliary trafficking of integral membrane proteins.	PKD1 NPFFR1	1.71e-03	25	85	2	28154160
Pubmed	Large-scale identification of c-MYC-associated proteins using a combined TAP/MudPIT approach.	PTGES2 NUP133 C1QBP HNRNPK	1.82e-03	211	85	4	17314511
Pubmed	RNA-binding proteins with basic-acidic dipeptide (BAD) domains self-assemble and aggregate in Alzheimer's disease.	ZNF48 FAM120A ATXN2 EIF4G1 C1QBP NME4 HNRNPK	1.83e-03	713	85	7	29802200
Pubmed	Anticancer sulfonamides target splicing by inducing RBM39 degradation via recruitment to DCAF15.	FAM120A ATXN2 PRDX4 EIF4G1 C1QBP SEZ6L2 HNRNPK	1.85e-03	714	85	7	28302793
Pubmed	Positioning of five genes (CASK, ARX, SAT, IMAGE cDNAs 248928 and 253949) from the human X chromosome short arm with respect to evolutionary breakpoints on the mouse X chromosome.	ARX GPR143	1.85e-03	26	85	2	10920247
Pubmed	Aberrant differentiation of second heart field mesoderm prefigures cellular defects in the outflow tract in response to loss of FGF8.	ISLR2 SCRIB	1.85e-03	26	85	2	37060937
Pubmed	Identification of Human Neuronal Protein Complexes Reveals Biochemical Activities and Convergent Mechanisms of Action in Autism Spectrum Disorders.	ATXN2 EIF4G1 CROCC	1.98e-03	101	85	3	26949739
Pubmed	Role of neuroepithelial Sonic hedgehog in hypothalamic patterning.	ARX HCRT	2.14e-03	28	85	2	19474326
Pubmed	Meta-analysis of genome-wide association studies in East Asian-ancestry populations identifies four new loci for body mass index.	TMEM160 ITIH4	2.14e-03	28	85	2	24861553
Pubmed	E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.	KDM4D PRR35 WIZ TMEM160 PKD1 SCRIB HNRNPK	2.19e-03	736	85	7	29676528
Pubmed	Defining the membrane proteome of NK cells.	FAM120A RASAL3 CLCN7 LRP10 ATXN2 EIF4G1 NUP133 ANKLE2 HNRNPK	2.21e-03	1168	85	9	19946888
Pubmed	Genome-wide meta-analyses of multiancestry cohorts identify multiple new susceptibility loci for refractive error and myopia.	PRSS56 LAMA2	2.30e-03	29	85	2	23396134
Pubmed	Quantitative Proteomics Links the LRRC59 Interactome to mRNA Translation on the ER Membrane.	CLCN7 PRDX4 NUP133 ANKLE2 HNRNPK	2.30e-03	375	85	5	32788342
Cytoband	16p13.3	PRR35 METRN PKD1 HCFC1R1 NME4 AXIN1	6.98e-06	244	86	6	16p13.3
Cytoband	Ensembl 112 genes in cytogenetic band chr16p13	PRR35 METRN CLCN7 PKD1 HCFC1R1 NME4 AXIN1	1.61e-05	426	86	7	chr16p13
Cytoband	8q24.3	PARP10 SCRIB KIFC2	1.28e-03	113	86	3	8q24.3
Cytoband	Ensembl 112 genes in cytogenetic band chr20p13	SOX12 DNAAF9 GFRA4	1.63e-03	123	86	3	chr20p13
Cytoband	Ensembl 112 genes in cytogenetic band chr19q13	PTOV1 GFY TMEM160 TSEN34 BLOC1S3 APLP1 LTBP4 BBC3	1.79e-03	1192	86	8	chr19q13
Cytoband	7q22	ZAN TFR2	2.33e-03	38	86	2	7q22
GeneFamily	PDZ domain containing	SCRIB RIMS2 TAMALIN RGS3	1.10e-03	152	54	4	1220
GeneFamily	Sulfatases	ARSB GNS	1.30e-03	18	54	2	410
Coexpression	NIKOLSKY_BREAST_CANCER_16P13_AMPLICON	PRR35 METRN CLCN7 PKD1 HCFC1R1 NME4 AXIN1	1.33e-07	119	86	7	M1788
Coexpression	HE_LIM_SUN_FETAL_LUNG_C1_GHRL_POS_NEUROENDOCRINE_CELL	CNNM1 PSD ARX BACE1 APLP1 RIMS2 SEZ6L2	8.02e-07	155	86	7	M45695
Coexpression	HE_LIM_SUN_FETAL_LUNG_C1_GHRL_POS_NE_PRECURSOR_CELL	CNNM1 PSD ARX PKD1 BACE1 APLP1 RIMS2 SEZ6L2 REEP2	1.17e-05	429	86	9	M45694
ToppCell	facs-Brain_Non-Myeloid-Striatum-24m-Neuronal-neuron\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1B CNNM1 PSD EXTL1 NYAP1 KCNH4	1.27e-06	178	86	6	a74e5a390cbeaca9de1fdb7b2a0e50783bd202dd
ToppCell	facs-Brain_Non-Myeloid-Striatum-24m-Neuronal-nan\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1B CNNM1 PSD EXTL1 NYAP1 KCNH4	1.27e-06	178	86	6	1bddbc083c36657bd6910f7466126ab325e88176
ToppCell	facs-Brain_Non-Myeloid-Striatum-24m-Neuronal\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1B CNNM1 PSD FGF3 NYAP1 KCNH4	1.32e-06	179	86	6	a3922476f33d2e4137a12dbda21a1703dff79684
ToppCell	wk_08-11-Epithelial-Proximal_epithelial-GHRL+_neuroendocrine\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	CACNA1B CNNM1 ARX APLP1 RIMS2 SEZ6L2	1.86e-06	190	86	6	b5c6f3248c0c2f648e1578457c6a729ca22bf0da
ToppCell	proximal-Epithelial-Neuroendocrine\|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	CACNA1B PSD APLP1 RIMS2 REEP2 KCNH4	2.36e-06	198	86	6	5dea6078488d584513c0bdbf5bba54877310b54a
ToppCell	proximal-Epithelial-Neuroendocrine-3\|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	CACNA1B PSD APLP1 RIMS2 REEP2 KCNH4	2.36e-06	198	86	6	00ccf3020667cf2130bc354b441b65c0b1b0e862
ToppCell	proximal-3-Epithelial-Neuroendocrine\|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	CACNA1B PSD APLP1 RIMS2 REEP2 KCNH4	2.36e-06	198	86	6	a6bc043faf68468d46bac441cf7447c236c7bae4
ToppCell	PND01-03-samps-Mesenchymal-Myofibroblast-MyoFB-3\|PND01-03-samps / Age Group, Lineage, Cell class and subclass	POLR3D PSD LAMA2 APLP1 KIFC2	6.47e-06	135	86	5	5b13ff740d9f7d96274aebb6b389a80f6004adc7
ToppCell	facs-Marrow-B-cells-24m-Lymphocytic-CD4-positive,_alpha-beta_T_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LAG3 ASTN2 APLP1 GFRA4 NYAP1	1.81e-05	167	86	5	713899690e4acd9d259645e363c26983d6ef3022
ToppCell	facs-Marrow-B-cells-24m-Lymphocytic-BM_CD4_T_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LAG3 ASTN2 APLP1 GFRA4 NYAP1	1.81e-05	167	86	5	d30b96c39da3dd02500443877a4eb3500e26802c
ToppCell	saliva-Severe-critical_progression_d28-40-Lymphocytic-Lymphocytic_B-B_cell-B_c01-TCL1A\|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)	CNNM1 SOWAHA LINC02875 CROCC SEZ6L2	1.87e-05	168	86	5	9a8709d34865cfa668d8f3335dc34fc86fc32482
ToppCell	5'-Adult-SmallIntestine-Epithelial-neuro-epithelial\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PSD ARX APLP1 RIMS2 SEZ6L2	2.15e-05	173	86	5	30fa8c14c8a1f546f380132c0c28a61e6a2f9fc4
ToppCell	3'-GW_trimst-2-SmallIntestine-Neuronal-neurons_B-Branch_B3_(IPAN)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CACNA1B APLP1 TMEM271 NYAP1 REEP2	2.33e-05	176	86	5	04dad262929581872e5bbc66cd8182c963e7e52f
ToppCell	wk_20-22-Epithelial-Proximal_epithelial-GHRL+_neuroendocrine\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	CNNM1 SOWAHA APLP1 RIMS2 SEZ6L2	2.53e-05	179	86	5	06f92c884189197c86793191c05f65e34925c097
ToppCell	5'-GW_trimst-2-SmallIntestine-Epithelial-neuro-epithelial-M/X_cells_(MLN/GHRL+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CNNM1 ARX APLP1 RIMS2 SEZ6L2	2.67e-05	181	86	5	cb17c904ab86d56dd30cac9b61acbb3b76f84ded
ToppCell	wk_15-18-Epithelial-Proximal_epithelial-GHRL+_neuroendocrine\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	CNNM1 ARX APLP1 RIMS2 SEZ6L2	2.81e-05	183	86	5	8820cfed27b292bc0bc9cde4005219ed41900552
ToppCell	5'-Parenchyma_lung-Immune_Lymphocytic-Lymphocytic_T/NK-CD8-positive,_alpha-beta_T_cell-CD8_T_cells-CD8_T_cells_L.1.1.2.1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	RASAL3 LAG3 FNBP4 BLOC1S3 RAVER1	2.81e-05	183	86	5	cea27d5e0ec1145d4606c41c18de29035b4aeabe
ToppCell	5'-GW_trimst-1.5-LargeIntestine-Neuronal-neurons_A-Branch_A3_(IPAN/IN)\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CACNA1B ISLR2 APLP1 REEP2 ITIH4	2.96e-05	185	86	5	110d5f02759c8235b14aea524ea47199696094ea
ToppCell	droplet-Liver-LIVER_HEP-30m-Lymphocytic-nan\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZNF48 ARX APLP1 SEZ6L2 KIFC2	3.04e-05	186	86	5	f5468e03321ea2083e223eb0d92c3a9307039569
ToppCell	droplet-Pancreas-Endocrine-21m-Epithelial-pancreatic_A_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ARX LAMA2 ASTN2 APLP1 SEZ6L2	3.04e-05	186	86	5	16092819e9148dfe64f07c737652b6e533e699f7
ToppCell	facs-Pancreas-Endocrine-24m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EIF4G1 APLP1 DNAAF9 SEZ6L2 GNS	3.20e-05	188	86	5	a91443aa8fa8fa87f7501c59219daa0305bd0bbf
ToppCell	5'-GW_trimst-2-SmallIntestine-Neuronal-neurons_A-Branch_A4_(IN)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CACNA1B ISLR2 APLP1 TMEM271 REEP2	3.28e-05	189	86	5	cceca3d14dd559bbb2cb4b81ea12c2b62d18ee49
ToppCell	Globus_pallidus-Neuronal\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	CACNA1B CNNM1 PSD NYAP1 KIFC2	3.36e-05	190	86	5	416de85d8841dac883faa6f5339b2fb461a09e82
ToppCell	Brain_organoid-organoid_Kanton_Nature-Organoid-4M-Neuronal-ventral_progenitors_and_neurons_1\|Organoid-4M / Sample Type, Dataset, Time_group, and Cell type.	SOWAHA APLP1 RIMS2 SEZ6L2 KIFC2	3.36e-05	190	86	5	6e92c78799f34b31d098854503c796edb0dc7f80
ToppCell	11.5-Airway-Epithelial-Neuroendocrine\|Airway / Age, Tissue, Lineage and Cell class	ARX APLP1 RIMS2 SEZ6L2 REEP2	3.45e-05	191	86	5	c1bb3ae5c297f55cdadf5b6e53d5296389d5099e
ToppCell	droplet-Pancreas-Endocrine\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PTOV1 EIF4G1 APLP1 SEZ6L2 GNS	3.54e-05	192	86	5	0dfd1e9896c34aee0f842f8de5d0e3af62a15f68
ToppCell	TCGA-Adrenal-Primary_Tumor-Pheochromocytoma\|TCGA-Adrenal / Sample_Type by Project: Shred V9	PSD ASTN2 APLP1 NYAP1 REEP2	3.71e-05	194	86	5	b6488bc3a8905e926ad298332963e1bbaf010046
ToppCell	TCGA-Adrenal-Primary_Tumor-Pheochromocytoma-Pheochromocytoma\|TCGA-Adrenal / Sample_Type by Project: Shred V9	PSD ASTN2 APLP1 NYAP1 REEP2	3.71e-05	194	86	5	1e1f4139ad584f493d75a9b7f1568eca4653c5a2
ToppCell	facs-Thymus-Epithelium\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SOWAHA TIE1 ARX APLP1 LTBP4	3.71e-05	194	86	5	255d6eead8da740a942a5e7d554dbd895d736d1a
ToppCell	3'-GW_trimst-1-SmallIntestine-Neuronal-neurons_A-Branch_A3_(IPAN/IN)\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CACNA1B ISLR2 APLP1 SEZ6L2 REEP2	3.81e-05	195	86	5	5a6a5048af638872700b76b7c71a8fa3fb8d3772
ToppCell	facs-Brain_Myeloid-Cortex_-18m-Myeloid-nan\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RASAL3 LRP10 LAG3 GNS HNRNPK	4.00e-05	197	86	5	e73ca8c8f42cbcc56eaa5fe3d69abd1ce7b7bbca
ToppCell	3'-GW_trimst-1-LargeIntestine-Neuronal-neurons_A-Branch_A2_(IPAN/IN)\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CACNA1B ISLR2 APLP1 SEZ6L2 REEP2	4.00e-05	197	86	5	27c044833e471a312a572e0b1c83e4bc8a36e896
ToppCell	facs-Brain_Myeloid-Cortex_\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RASAL3 LRP10 LAG3 GNS HNRNPK	4.00e-05	197	86	5	81379fe6bd14a1ba26f4a159497262adcb600b18
ToppCell	facs-Brain_Myeloid-Cortex_-18m\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RASAL3 LRP10 LAG3 GNS HNRNPK	4.00e-05	197	86	5	271c75f491d03bd248c7ec037ef02e39456f3ac0
ToppCell	Tracheal-10x5prime-Epithelial-Epi_airway_neuro-secretory-Neuroendocrine\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	SOX12 CNNM1 KDM4D ZNF48 ZXDA	4.00e-05	197	86	5	fd76cc5e12c7e7943a48f739e4f0626ff7211f51
ToppCell	3'-GW_trimst-1-SmallIntestine-Neuronal-neurons_A-Branch_A2_(IPAN/IN)\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CACNA1B ISLR2 APLP1 SEZ6L2 REEP2	4.00e-05	197	86	5	f7eaac1c321710a55e09ffb047a7db2baf7b7e28
ToppCell	facs-Brain_Myeloid-Cortex_-18m-Myeloid\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RASAL3 LRP10 LAG3 GNS HNRNPK	4.00e-05	197	86	5	9db329c6fea532dd1afb624f4c29c92407f45568
ToppCell	COVID-19_Moderate-CD8+_T_activated\|COVID-19_Moderate / disease group, cell group and cell class	PARP10 RASAL3 METRN LAG3 CMPK2	4.00e-05	197	86	5	4711ecb157e907758a5021248ae8b043d17672c6
ToppCell	facs-Brain_Myeloid-Cortex_-18m-Myeloid-microglial_cell\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RASAL3 LRP10 LAG3 GNS HNRNPK	4.00e-05	197	86	5	173c0c8de4e69882a9f91189deeb4a651fefe551
ToppCell	Brain_organoid-organoid_Kanton_Nature-Organoid-2M-Neuronal-ventral_progenitors_and_neurons_1\|Organoid-2M / Sample Type, Dataset, Time_group, and Cell type.	ISLR2 SOWAHA APLP1 RIMS2 SEZ6L2	4.00e-05	197	86	5	4961f66606f08e399508fd6cabca588e7ab406a8
ToppCell	Brain_organoid-organoid_Velasco_nature-3_mon-Radial_glial-oRG\|3_mon / Sample Type, Dataset, Time_group, and Cell type.	TGIF1 METRN LRP10 ARX NME4	4.09e-05	198	86	5	72dc49aa107d0cc6206eb67b577c73e190855125
ToppCell	3'-GW_trimst-1-LargeIntestine-Neuronal-neurons_A\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CACNA1B ISLR2 APLP1 SEZ6L2 REEP2	4.09e-05	198	86	5	800ade4261695f2efd869d2b1243571de963c431
ToppCell	3'-GW_trimst-1-SmallIntestine-Neuronal-neurons_A\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CACNA1B ISLR2 APLP1 SEZ6L2 REEP2	4.19e-05	199	86	5	ce8dbfd969b3b9c08e1c57c2bfd899818e878731
ToppCell	TCGA-Skin-Metastatic-Melanoma-Skin_Cutaneous_Melanoma-4\|TCGA-Skin / Sample_Type by Project: Shred V9	PTGES2 TMEM160 HCFC1R1 BLOC1S3 NME4	4.19e-05	199	86	5	bbda9060918797303984ca2b64e9bb73fdacd0c4
ToppCell	LPS_IL1RA-Endothelial-Endothelial-Artery\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	TIE1 APLP1 LTBP4 TAMALIN RGS3	4.29e-05	200	86	5	ac9ead34afa14067171833f5c277eaf06db7b02e
Disease	lymphocyte activation gene 3 protein measurement	ATXN2 LAG3	2.17e-05	3	80	2	EFO_0020540
Disease	axial length measurement	ZNF469 PRSS56 LAMA2 AXIN1	5.83e-05	77	80	4	EFO_0005318
Disease	gamma-glutamylmethionine measurement	CACNA1B ASTN2	1.51e-04	7	80	2	EFO_0021141
Disease	late onset Parkinson's disease (is_implicated_in)	ATXN2 EIF4G1	3.93e-04	11	80	2	DOID:0060892 (is_implicated_in)
Disease	hematocrit	ZAN TIE1 ATXN2 BLOC1S3 DNAAF9 CROCC NYAP1 LTBP4 RGS3 TFR2	4.00e-04	1011	80	10	EFO_0004348
Disease	Congenital muscular dystrophy	LAMA2 POMGNT1	4.71e-04	12	80	2	cv:C0699743
Disease	Connective Tissue Diseases	ZNF469 PKD1	5.55e-04	13	80	2	C0009782
Disease	Myopia	PRSS56 LAMA2	7.45e-04	15	80	2	C0027092
Disease	muscular dystrophy (is_implicated_in)	LAMA2 POMGNT1	9.61e-04	17	80	2	DOID:9884 (is_implicated_in)
Disease	anthropometric measurement	ZNF469 ATXN2 LINC02875 ASTN2	1.15e-03	168	80	4	EFO_0004302
Disease	eye measurement	ZNF469 ATXN2	2.44e-03	27	80	2	EFO_0004731
Disease	Schizophrenia	CACNA1B PSD ATXN2 LAMA2 BACE1 BLOC1S3 ASTN2 RIMS2	2.70e-03	883	80	8	C0036341

Protein segments in the cluster

Peptide	Gene	Start	Entry
GLARDGPRPFPLGRL	BBC3	16	Q9BXH1
ARPRLGRGSPPTRRG	AGBL5	786	Q8NDL9
RSGLGGAPLGLRLPR	BACE1	31	P56817
LVRRLGPRPGGLGRS	ANKLE2	31	Q86XL3
GSERRPGLLRPRGPC	C1QBP	51	Q07021
PAARGLSRRPGQPPL	APLP1	6	P51693
TPGRGGRRQLPQTPL	CACNA1B	2181	Q00975
ARLSPGPGSGLRGRP	ASTN2	6	O75129
AGGAPRPGRRPLRLL	ISLR2	516	Q6UXK2
RPGVLSSRQLGLPGP	ITIH4	661	Q14624
PPARRLSLRLRGLGP	RASAL3	361	Q86YV0
PAPVGLRGSGLRGPL	RAVER1	466	Q8IY67
LRPLRDPLLRMPGGG	RGS3	276	P49796
RNPGGGTLRPAASLP	KIAA0895L	106	Q68EN5
SGAPRPGRLPLRNGR	NPFFR1	391	Q9GZQ6
RRGPLAGLGPGSTPR	NUP133	16	Q8WUM0
QALRGRLLPSLGPPG	LRP10	656	Q7Z4F1
RLTLGGPDPRARPGI	METRN	66	Q9UJH8
SRRLLGLGGPPRPFV	ATXN2	91	Q99700
SGLPRPPGKGVQPRR	FGF3	196	P11487
APLLRRTARPGGGTP	CLCN7	21	P51798
PSNGRRGRGRPPQKL	KDM4D	446	Q6B0I6
GGPRPRRPLLLPNLS	KCNH4	736	Q9UQ05
GSGGTPAPPRRKRRQ	LAMA2	2566	P24043
PGGLRSGRLPLQPRV	LAG3	106	P18627
LVGGGRQRPPQTPLR	FAM120A	31	Q9NZB2
PLLAVPGRPRGGARR	TAMALIN	261	Q7Z6J2
PLGGRGRPPRPLVVR	PTOV1	16	Q86YD1
GPAGGLAPRPLREQL	PRR35	426	P0CG20
GRRGRQLPQLPPKGT	RIMS2	1156	Q9UQ26
RLLRGPLSGPLLGRR	CMPK2	6	Q5EBM0
RRGLGLGRAPSPAPR	CROCC	1441	Q5TZA2
RLPAGPGRPLPARLR	GFRA4	176	Q9GZZ7
PGRPLPARLRGPRGV	GFRA4	181	Q9GZZ7
PPRGGRPQRLEALSP	GFY	496	I3L273
QRVLRTPGRQSPGPG	AXIN1	476	O15169
LQLLPGRRPAGPGSP	GPR143	46	P51810
GSEPRARPGLGPRQL	LINC02875	171	Q86X59
ARPGLGPRQLLTGPR	LINC02875	176	Q86X59
PRRQGLPRARSPGGS	DNAAF9	6	Q5TEA3
LGPSGPTRGRPTGLR	BLOC1S3	41	Q6QNY0
ELPRGPAGLGPRRSQ	EIF4G1	691	Q04637
LAPGRLRRGSPRHLP	GNS	6	P15586
LLKRRRPRGPGGRGL	LTBP4	121	Q8N2S1
RPRGPGGRGLLRRRP	LTBP4	126	Q8N2S1
AASLPRGPGPRRLLL	ARSB	6	P15848
LPPKLRRLYGPGGGR	ARX	81	Q96QS3
PLQRGPQGGAQRLPR	HCFC1R1	6	Q9NWW0
QPGAAGSRAPPGRLL	KIFC2	761	Q96AC6
LLGLRPNPGLRLPGR	PKD1	781	P98161
GPRPGLRRLAPALAL	PRSS56	416	P0CW18
GRRGLRAPPLRGPGH	PARP10	956	Q53GL7
LGKRRSGPPGLQGRL	HCRT	66	O43612
PRGGNLPLQRLTRGS	NYAP1	186	Q6ZVC0
VRVPGRPRPHGGSLL	NRAC	91	Q8N912
GPASARAQLLGPRPR	PIF1	131	Q9H611
TGARGLIGRRPAPPL	POLR3D	21	P05423
LGIRIPRPLGQGPSR	SESN1	36	Q9Y6P5
VRPLNGLPAPGGLSR	PSD	111	A5PKW4
NTPRRQGGLGPIRIP	PRDX4	161	Q13162
LPPGQGVLTGLRAPR	TOGARAM2	261	Q6ZUX3
RRPILQLSPPGPRGS	FNBP4	11	Q8N3X1
RGLRCGPRAPGPSLL	NME4	11	O00746
ALGRLEPPRRRGSGP	POMGNT1	81	Q8WZA1
RGGRGGSRARNLPLP	HNRNPK	296	P61978
GARSPKRPRLQLPGA	PRR14	26	Q9BWN1
ARGLLGGRRPPGLRL	SHISA8	6	B8ZZ34
GGRRPPGLRLALALR	SHISA8	11	B8ZZ34
RLGGRPQPLLPTQSR	PTGES2	21	Q9H7Z7
GGPPGSFLTSRRPRL	WIZ	831	O95785
LRGPQPRRRLLSSGP	SEZ6L2	596	Q6UXD5
PRERRGGGLRLPLLP	SCRIB	836	Q14160
LLLRALRRGPGPGPR	SPG7	6	Q9UQ90
RLALPPRPRPGASQG	EXTL1	31	Q92935
RVRPRLYGPGGDLLP	CNNM1	206	Q9NRU3
PGRQGRRALKPVGPL	C11orf42	66	Q8N5U0
PSQGAQGPAPRRRLL	TGIF1	116	Q15583
GKPQPRDRGPRLLGE	ZNF48	86	Q96MX3
PRGGCLLPPRLGSQQ	nan	71	Q6ZSN1
QRPDGRLRPSPGSLL	REEP2	166	Q9BRK0
LGLGLGPGRSPHLRR	SOWAHA	266	Q2M3V2
LPRGPRQNSRLGLPL	TSEN34	36	Q9BSV6
LKPGPQLPGRGGRRA	SOX12	136	O15370
RTPPGPPLRLARNGS	TIE1	71	P35590
GPGRSPQARGPSRSL	ZNF469	1136	Q96JG9
AGQVPTRRLLLPRGP	ZXDA	36	P98168
TRRLLLPRGPQDGGP	ZXDA	41	P98168
PLLRSLRGRPAGGPD	TARBP1	71	Q13395
SLLPPQRPRSGGARG	TMEM160	21	Q9NX00
LRSGPSQPRGLRLPV	nan	106	Q8N6K4
LARPRGGSGLRAQPP	TMEM271	261	A0A286YF58
LRGPEPLGSRPRQPN	TFR2	56	Q9UP52
QGPRGRRLSPQTGIP	nan	291	Q8N7P7
LRGPGARRPSLLPQG	VWA5B1	726	Q5TIE3
LCQPGRPRGLRGPLR	ZAN	2616	Q9Y493
ELRRGLRGRSGPPPG	NCBP2AS2	76	Q69YL0