Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionRNA polymerase II transcription regulatory region sequence-specific DNA binding

SP8 ZNF705A ZNF444 IKZF2 ZNF337 ZNF425 ZNF596 ZNF335 ZKSCAN3 OSR1 ZNF267 ZFHX2 ZNF75D ZNF808 IKZF1 ZNF705B KDM6B ZNF714 ZNF786 ZNF705D

5.96e-0814596920GO:0000977
GeneOntologyMolecularFunctionDNA-binding transcription factor activity, RNA polymerase II-specific

SP8 ZNF705A ZNF444 ZNF337 ZNF425 ZNF596 ZKSCAN3 OSR1 ZNF267 ZFHX2 ZNF75D ISL2 ZNF808 IKZF1 ZNF579 ZNF705B ZNF714 ZNF786 ZNF705D

1.87e-0714126919GO:0000981
GeneOntologyMolecularFunctioncis-regulatory region sequence-specific DNA binding

SP8 ZNF444 IKZF2 ZNF335 ZKSCAN3 ZNF267 ZFHX2 ZNF75D ISL2 ZNF808 IKZF1 KDM6B ZNF714 ZNF786

9.48e-0512716914GO:0000987
GeneOntologyMolecularFunctionRNA polymerase II cis-regulatory region sequence-specific DNA binding

SP8 ZNF444 IKZF2 ZNF335 ZKSCAN3 ZNF267 ZFHX2 ZNF75D ZNF808 IKZF1 KDM6B ZNF714 ZNF786

2.94e-0412446913GO:0000978
Domain-

SP8 ZNF705A ZNF444 PRDM9 IKZF2 ZNF337 ZNF425 ZNF596 ZNF335 ZKSCAN3 OSR1 ZNF267 ZFHX2 ZNF75D ZNF808 IKZF1 ZNF579 ZNF705B ZNF285 ZNF714 ZNF786 ZNF705D ZXDB

9.32e-1767968233.30.160.60
Domainzf-C2H2

SP8 ZNF705A ZNF444 PRDM9 IKZF2 ZNF337 ZNF425 ZNF596 ZNF335 ZKSCAN3 OSR1 ZNF267 ZFHX2 ZNF75D ZNF808 IKZF1 ZNF579 ZNF705B ZNF285 ZNF714 ZNF786 ZNF705D ZXDB

1.45e-166936823PF00096
DomainZnf_C2H2/integrase_DNA-bd

SP8 ZNF705A ZNF444 PRDM9 IKZF2 ZNF337 ZNF425 ZNF596 ZNF335 ZKSCAN3 OSR1 ZNF267 ZFHX2 ZNF75D ZNF808 IKZF1 ZNF579 ZNF705B ZNF285 ZNF714 ZNF786 ZNF705D ZXDB

1.50e-166946823IPR013087
DomainZINC_FINGER_C2H2_2

SP8 ZNF705A ZNF444 PRDM9 IKZF2 ZNF337 ZNF425 ZNF596 ZNF335 ZKSCAN3 OSR1 ZNF267 ZFHX2 ZNF75D ZNF808 IKZF1 ZNF579 ZNF705B ZNF285 ZNF714 ZNF786 ZNF705D ZXDB

1.63e-157756823PS50157
DomainZINC_FINGER_C2H2_1

SP8 ZNF705A ZNF444 PRDM9 IKZF2 ZNF337 ZNF425 ZNF596 ZNF335 ZKSCAN3 OSR1 ZNF267 ZFHX2 ZNF75D ZNF808 IKZF1 ZNF579 ZNF705B ZNF285 ZNF714 ZNF786 ZNF705D ZXDB

1.72e-157776823PS00028
DomainZnf_C2H2-like

SP8 ZNF705A ZNF444 PRDM9 IKZF2 ZNF337 ZNF425 ZNF596 ZNF335 ZKSCAN3 OSR1 ZNF267 ZFHX2 ZNF75D ZNF808 IKZF1 ZNF579 ZNF705B ZNF285 ZNF714 ZNF786 ZNF705D ZXDB

2.88e-157966823IPR015880
DomainZnf_C2H2

SP8 ZNF705A ZNF444 PRDM9 IKZF2 ZNF337 ZNF425 ZNF596 ZNF335 ZKSCAN3 OSR1 ZNF267 ZFHX2 ZNF75D ZNF808 IKZF1 ZNF579 ZNF705B ZNF285 ZNF714 ZNF786 ZNF705D ZXDB

3.67e-158056823IPR007087
DomainZnF_C2H2

SP8 ZNF705A ZNF444 PRDM9 IKZF2 ZNF337 ZNF425 ZNF596 ZNF335 ZKSCAN3 OSR1 ZNF267 ZFHX2 ZNF75D ZNF808 IKZF1 ZNF579 ZNF705B ZNF285 ZNF714 ZNF786 ZNF705D ZXDB

3.97e-158086823SM00355
DomainKRAB

ZNF705A PRDM9 ZNF337 ZNF425 ZNF596 ZKSCAN3 ZNF267 ZNF75D ZNF808 ZNF705B ZNF285 ZNF714 ZNF786 ZNF705D

5.07e-113696814SM00349
DomainKRAB

ZNF705A PRDM9 ZNF337 ZNF425 ZNF596 ZKSCAN3 ZNF267 ZNF75D ZNF808 ZNF705B ZNF285 ZNF714 ZNF786 ZNF705D

5.25e-113706814IPR001909
DomainKRAB

ZNF705A ZNF337 ZNF425 ZNF596 ZKSCAN3 ZNF267 ZNF75D ZNF808 ZNF705B ZNF285 ZNF714 ZNF786 ZNF705D

4.60e-103586813PS50805
DomainKRAB

ZNF705A PRDM9 ZNF337 ZNF425 ZNF596 ZKSCAN3 ZNF267 ZNF75D ZNF808 ZNF705B ZNF285 ZNF786 ZNF705D

4.60e-103586813PF01352
Domainzf-C2H2_6

PRDM9 ZNF425 OSR1 ZNF267 ZNF808 ZNF714

9.82e-04314686PF13912
DomainKrueppel-associated_box-rel

PRDM9 ZNF425

9.93e-0413682IPR003655
Domain-

FBXL8 RTN4R CNTRL DMAC2 FBXL19 NLRP2

1.10e-033216863.80.10.10
DomainSCAN

ZNF444 ZKSCAN3 ZNF75D

1.11e-0356683SM00431
DomainL_dom-like

FBXL8 RTN4R CNTRL DMAC2 FBXL19 NLRP2

1.23e-03328686IPR032675
DomainSCAN_BOX

ZNF444 ZKSCAN3 ZNF75D

1.23e-0358683PS50804
DomainSCAN

ZNF444 ZKSCAN3 ZNF75D

1.23e-0358683PF02023
DomainSCAN_dom

ZNF444 ZKSCAN3 ZNF75D

1.23e-0358683IPR003309
DomainRetrov_capsid_C

ZNF444 ZKSCAN3 ZNF75D

1.30e-0359683IPR008916
DomainChromodomain-like

ARID4B CHD9

6.04e-0332682IPR016197
DomainCHROMO

ARID4B CHD9

6.41e-0333682SM00298
DomainChromo/shadow_dom

ARID4B CHD9

6.41e-0333682IPR000953
Pubmed

Helios deficiency has minimal impact on T cell development and function.

IKZF2 IKZF1

4.11e-06271219620299
Pubmed

Nek2 and its substrate, centrobin/Nip2, are required for proper meiotic spindle formation of the mouse oocytes.

NEK2 CNTROB

4.11e-06271220569513
Pubmed

NEK2 phosphorylation antagonizes the microtubule stabilizing activity of centrobin.

NEK2 CNTROB

4.11e-06271223291182
Pubmed

Genetic polymorphisms in centrobin and Nek2 are associated with breast cancer susceptibility in a Chinese Han population.

NEK2 CNTROB

4.11e-06271223001753
Pubmed

Predominant interaction of both Ikaros and Helios with the NuRD complex in immature thymocytes.

IKZF2 IKZF1

4.11e-06271217681952
Pubmed

[Expression characteristics of isoforms of Ikaros and Helios in patients with leukemia and their mechanism].

IKZF2 IKZF1

4.11e-06271222931634
Pubmed

Overexpression of novel short isoforms of Helios in a patient with T-cell acute lymphoblastic leukemia.

IKZF2 IKZF1

1.23e-05371211937265
Pubmed

Helios, a novel dimerization partner of Ikaros expressed in the earliest hematopoietic progenitors.

IKZF2 IKZF1

1.23e-0537129560339
Pubmed

Association of single nucleotide polymorphisms of MTHFR, TCN2, RNF213 with susceptibility to hypertension and blood pressure.

MTHFR RNF213

1.23e-05371231815282
Pubmed

Analysis of Ikaros family splicing variants in human hematopoietic lineages.

IKZF2 IKZF1

1.23e-05371220432734
Pubmed

Expression patterns of Ikaros family members during positive selection and lineage commitment of human thymocytes.

IKZF2 IKZF1

1.23e-05371227502439
Pubmed

Odd-skipped related 1 gene expression is regulated by Runx2 and Ikzf1 transcription factors.

OSR1 IKZF1

1.23e-05371218804520
Pubmed

Characterization of NIP2/centrobin, a novel substrate of Nek2, and its potential role in microtubule stabilization.

NEK2 CNTROB

1.23e-05371217535851
Pubmed

Aberrant Ikaros, Aiolos, and Helios expression in Hodgkin and non-Hodgkin lymphoma.

IKZF2 IKZF1

1.23e-05371218332232
Pubmed

Interaction between the scaffold proteins CBP by IQGAP1 provides an interface between gene expression and cytoskeletal activity.

ACSS1 CNTRL HUWE1 KDM6B

1.25e-056971432238831
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

SBF1 MTHFR ZNF335 PLA2G6 JADE1 ZNF579 HUWE1 FBXL19 KDM6B CNTROB SH3BP4

1.42e-051105711135748872
Pubmed

Maturation of human dendritic cells is accompanied by functional remodelling of the ubiquitin-proteasome system.

FBXL8 RNF213 HUWE1 FBXL19

2.85e-058571419028597
Pubmed

Nip2/centrobin may be a substrate of Nek2 that is required for proper spindle assembly during mitosis in early mouse embryos.

NEK2 CNTROB

4.09e-05571219117032
Pubmed

Eos and pegasus, two members of the Ikaros family of proteins with distinct DNA binding activities.

IKZF2 IKZF1

4.09e-05571210978333
Pubmed

Centrosome-related genes, genetic variation, and risk of breast cancer.

NEK2 CNTRL TACC3 CNTROB

5.83e-0510271420508983
Pubmed

Expression of testicular germ cell genes identified by differential display analysis.

ANKRD18A ANKRD18B

1.14e-04871212634303
Pubmed

3D-structured illumination microscopy provides novel insight into architecture of human centrosomes.

CEP170 CNTRL

1.14e-04871223213374
Pubmed

Helios transcription factor expression depends on Gsx2 and Dlx1&2 function in developing striatal matrix neurons.

IKZF2 IKZF1

1.47e-04971222142223
Pubmed

Myh7b/miR-499 gene expression is transcriptionally regulated by MRFs and Eos.

IKZF2 IKZF1

1.47e-04971222638570
Pubmed

Novel asymmetrically localizing components of human centrosomes identified by complementary proteomics methods.

CEP170 NEK2 CNTRL CNTROB

2.33e-0414671421399614
Pubmed

Ikaros confers early temporal competence to mouse retinal progenitor cells.

IKZF2 IKZF1

3.16e-041371218940586
Pubmed

The functional interactome landscape of the human histone deacetylase family.

IKZF2 ARID4B WDR33 IKZF1 HUWE1

3.18e-0428971523752268
Pubmed

A central chaperone-like role for 14-3-3 proteins in human cells.

CEP170 CDK16 SBF1 MAP3K9 SIK3 ANKRD27 AKT1S1 SH3BP4

3.67e-0486171836931259
Pubmed

A molecular dissection of the repression circuitry of Ikaros.

IKZF2 IKZF1

3.68e-041471212015313
Pubmed

A directed protein interaction network for investigating intracellular signal transduction.

NEK2 SBF1 GPR39 IKZF1 JADE1 ZNF579 KDM6B AKT1S1 BBS10

4.60e-04112471921900206
Pubmed

Ikaros promotes early-born neuronal fates in the cerebral cortex.

IKZF2 IKZF1

6.87e-041971223382203
Pubmed

Defining the human C2H2 zinc finger degrome targeted by thalidomide analogs through CRBN.

OSR1 IKZF1

6.87e-041971230385546
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

SBF1 JADE1 SIK3 KDM6B ANKRD27 STAB1

7.47e-0452971614621295
Pubmed

The histone demethylase Kdm6b regulates subtype diversification of mouse spinal motor neurons during development.

ISL2 KDM6B

7.62e-042071235177643
Pubmed

Novel transcription factor Satb2 interacts with matrix attachment region DNA elements in a tissue-specific manner and demonstrates cell-type-dependent expression in the developing mouse CNS.

ISL2 STAB1

7.62e-042071215733084
Pubmed

The LIM homeobox gene Isl1 is required for the correct development of the striatonigral pathway in the mouse.

IKZF2 IKZF1

7.62e-042071224082127
Pubmed

Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.

SEPSECS PDE7A SLC39A2 MTHFR ZNF808 ZNF579 CNTROB ZNF714 HERC2P3

8.01e-04121571915146197
Pubmed

Large-scale characterization of HeLa cell nuclear phosphoproteins.

ARID4B ZNF335 ISL2 ZNF579 HUWE1 TACC3 AKT1S1

1.02e-0377471715302935
Pubmed

Avoiding mouse traps in schizophrenia genetics: lessons and promises from current and emerging mouse models.

MTHFR RTN4R

1.10e-032471221821099
Pubmed

A conserved acetylation switch enables pharmacological control of tubby-like protein stability.

SBF1 MTHFR CHD9 AKT1S1

1.14e-0322371433187986
Pubmed

A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning.

CEP170 CDK16 SEPSECS GMIP DEPDC7 CNTROB AKT1S1 BBS10

1.24e-03103871826673895
Pubmed

Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.

CHD9 HUWE1 KDM6B

1.28e-031047139205841
Pubmed

Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.

IKZF2 ZKSCAN3 OSR1 ISL2 JADE1 FBXL19 ZNF786

1.30e-0380871720412781
Pubmed

Uncoupling of bait-protein expression from the prey protein environment adds versatility for cell and tissue interaction proteomics and reveals a complex of CARP-1 and the PKA Cbeta1 subunit.

PDE7A SIK3

1.40e-032771220564261
Pubmed

Genome-wide association analysis identifies 13 new risk loci for schizophrenia.

CEP170 GMIP STAB1

1.47e-0310971323974872
Pubmed

Recruitment of the Mammalian Histone-modifying EMSY Complex to Target Genes Is Regulated by ZNF131.

ARID4B ZNF335 CHD9

1.50e-0311071326841866
Pubmed

A Retinoic Acid-Hedgehog Cascade Coordinates Mesoderm-Inducing Signals and Endoderm Competence during Lung Specification.

OSR1 ISL2

1.61e-032971227320915
Pubmed

Association of mitotic regulation pathway polymorphisms with pancreatic cancer risk and outcome.

SIK3 TACC3

1.96e-033271220056645
Pubmed

Dlx1/2-dependent expression of Meis2 promotes neuronal fate determination in the mammalian striatum.

SP8 IKZF1

1.96e-033271235156680
CytobandEnsembl 112 genes in cytogenetic band chr19q13

ZNF444 DMAC2 ZNF808 ZNF579 ZNF285 NLRP2 ANKRD27 AKT1S1

5.05e-041192718chr19q13
Cytoband17p13.1

KDM6B CNTROB PIK3R5

8.33e-0411871317p13.1
Cytoband20q13.12

ZNF335 KCNK15

3.94e-036071220q13.12
GeneFamilyZinc fingers C2H2-type|ZF class homeoboxes and pseudogenes

SP8 ZNF705A ZNF444 PRDM9 IKZF2 ZNF337 ZNF425 ZNF596 ZNF335 ZKSCAN3 OSR1 ZNF267 ZFHX2 ZNF75D ZNF808 IKZF1 ZNF579 ZNF705B ZNF285 ZNF714 ZNF786 ZNF705D ZXDB

2.91e-19718512328
GeneFamilyF-box and leucine rich repeat proteins

FBXL8 FBXL19

1.58e-0321512558
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Myeloid-Macrophage_Dendritic-Cycling_Mononuclear_Phagocyte|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

NEK2 CNTRL IKZF1 TACC3 PIK3R5 STAB1

5.44e-0718771673931a5ea73799095daff100b5f18853c57c74dc
DrugAlclometasone dipropionate [667634-13-2]; Up 200; 7.6uM; MCF7; HT_HG-U133A

SBF1 CYP2R1 MTHFR MAP3K9 ZNF75D IKZF1 KDM6B PIK3R5

1.24e-071966886229_UP
DiseaseL2 Acute Lymphoblastic Leukemia

IKZF2 MTHFR IKZF1

1.77e-0450643C0023453
DiseaseChildhood Acute Lymphoblastic Leukemia

IKZF2 MTHFR IKZF1

1.99e-0452643C0023452
DiseaseSCHIZOPHRENIA

MTHFR RTN4R

2.52e-0411642181500
DiseasePrecursor Cell Lymphoblastic Leukemia Lymphoma

IKZF2 MTHFR IKZF1

3.20e-0461643C1961102
DiseaseSchizophrenia

MTHFR RTN4R

6.93e-0418642cv:C0036341
Diseaseisthmus cingulate cortex volume measurement

SEPSECS PTCHD3

1.46e-0326642EFO_0010310
Diseasebasophil count, eosinophil count

IKZF2 IKZF1 SIK3 KDM6B

1.88e-03241644EFO_0004842, EFO_0005090
Diseasetriglyceride measurement, C-reactive protein measurement

ZNF335 PLA2G6

3.10e-0338642EFO_0004458, EFO_0004530
DiseaseMoyamoya disease

MTHFR RNF213

3.43e-0340642MONDO_0016820
DiseaseLymphoma

MTHFR IKZF1

3.43e-0340642C0024299

Protein segments in the cluster

PeptideGeneStartEntry
LRRSSLCLKGERHFA

ARID4B

101

Q4LE39
AHRRCSKRATLEEHL

CEP170

386

Q5SW79
CRLANTLKRHGVHRG

ACSS1

151

Q9NUB1
EAARRCLHDIALAHR

AKT1S1

56

Q96B36
HDCHGLVIARRALLR

ADAD2

281

Q8NCV1
LRHREDRLKAQLRHC

CNTRL

2241

Q7Z7A1
RKDRTVLHLACAHGR

ANKRD18A

66

Q8IVF6
RKDRTVLHLACAHGR

ANKRD18B

66

A2A2Z9
GLACLHHLQNLRRLD

DMAC2

191

Q9NW81
RHRLKRHNDCFVGSE

DEPDC7

56

Q96QD5
CHLLRGLHAITDREK

BBS10

91

Q8TAM1
RKDRTVLHLTCAHGR

ANKRD19P

66

Q9H560
RETLVHLNLAGCHRL

FBXL19

626

Q6PCT2
RTFRECERKSLRHHI

ANKRD27

161

Q96NW4
CRQRLEEITGHLHKA

MTHFR

131

P42898
CRLSLQHANHEKRLR

GPR39

361

O43194
TLALKECHRRSDGGH

NEK2

121

P51955
HKRCLETLLILCGHR

GMIP

526

Q9P107
CHVHKLERCARDNLG

KCNK15

291

Q9H427
KEHRRHRRACKDSVG

KDM6B

981

O15054
HLDRGDLCLEDTRHR

PDE7A

336

Q13946
ADAHRNLCLALRGHK

NLRP2

741

Q9NX02
ACRRRDALTGHLRTH

IKZF1

181

Q13422
ACRRRDALTGHLRTH

IKZF2

176

Q9UKS7
HATLRLCLRLTRDHK

HUWE1

1776

Q7Z6Z7
DICHKAFRRQDHLRD

OSR1

206

Q8TAX0
RAARRCLAQELHLHV

SBF1

596

O95248
ECGRGFRNKSHLLRH

PRDM9

836

Q9NQV7
QLHEGRPKQKRHRCR

CHD9

2531

Q3L8U1
LRGLAYCHRQKVLHR

CDK16

271

Q00536
CGAASQLRHLDLRRL

FBXL8

131

Q96CD0
FSLGRRHCLGEHLAR

CYP2R1

441

Q6VVX0
HRCREGALSLLQHLR

ETNK1

116

Q9HBU6
RLECSGRILAHHNLR

C9orf85

116

Q96MD7
TNSLKRGGAHHRRCE

MAP3K9

736

P80192
LRDALDSEHTRRKHC

CNTROB

186

Q8N137
RHRCHTDCLEGLLSR

PTCHD3

111

Q3KNS1
SLREHELLCRADHGL

ISL2

131

Q96A47
RLHTLHLDRCGLQEL

RTN4R

131

Q9BZR6
RELRSRCEELHGKNL

TACC3

656

Q9Y6A5
RKLARSCHDLDLLGQ

SH3BP4

291

Q9P0V3
LLCDRHKRHKTLRLG

SIK3

381

Q9Y2K2
RDEKRTHDHLLCLDG

PLA2G6

471

O60733
KSRLCSHRRALGDHS

HERC2P3

101

Q9BVR0
HGKRRDNRFHCDLIK

JADE1

656

Q6IE81
AGASLRRKGLHSCHI

SP8

346

Q8IXZ3
AARGHHRLVLRLLGC

SLC39A2

36

Q9NP94
GRLRDAAQRHCEHTK

RNF213

4101

Q63HN8
DKACRLKIHLRSHTG

ZXDB

436

P98169
ILRRHGKCEHENLQL

ZNF714

71

Q96N38
ECGKAFRRKEHLRRH

ZNF444

211

Q8N0Y2
FNLRRHERTHLGKKC

ZNF705A

241

Q6ZN79
CSDLRKHERTHLGDK

ZNF596

291

Q8TC21
CRGHLFSRQHLAKLK

ZFHX2

2161

Q9C0A1
DRIQHALERCLHGLS

PIK3R5

11

Q8WYR1
RRHGSCDLENLHLRK

ZNF267

101

Q14586
QKATLLCHRRLHSGE

ZNF808

746

Q8N4W9
CRARVGLELLRDKHA

STAB1

1581

Q9NY15
TLLGLGARRLHRHVC

TMEM82

161

A0PJX8
GCRQRSGHLHVRLKQ

nan

106

Q3C1V9
FNLRRHERTHLGQKC

ZNF705B

241

P0CI00
FNLRRHERTHLGQKC

ZNF705D

241

P0CH99
RKLCLLRHLAAHTGR

ZNF786

251

Q8N393
QCKLREHLRVHSGER

ZNF786

521

Q8N393
SLLRHQKLHRRREAC

ZNF75D

491

P51815
CGKAFRRSSHLLRHQ

ZKSCAN3

431

Q9BRR0
GCEARRSHEHLIRLL

SEPSECS

21

Q9HD40
FLRCHEERILRGHGA

WDR33

231

Q9C0J8
STRHKKNLRLHVRCR

ZNF335

686

Q9H4Z2
RANLKKHLCLHRGER

ZNF425

286

Q6IV72
KRSLKAHLCLHSGER

ZNF425

706

Q6IV72
LLRHQRCHRAELERA

ZNF579

456

Q8NAF0
CERGKDLLTHQRLHE

ZNF285

571

Q96NJ3
HLKRHLREKRFCTGS

ZNF337

731

Q9Y3M9