Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctioncalcium ion binding

NUCB2 PCDHAC2 PCDHAC1 PCDHA10 PCDHA7 PCDHA4 PCDHA2 ADAM8 EFHC2 DST OTOF C1R EGFLAM PLCB3 PADI6

9.66e-0674910615GO:0005509
DomainCadherin_tail

PCDHAC2 PCDHAC1 PCDHA10 PCDHA7 PCDHA4 PCDHA2

5.52e-08371056PF15974
DomainCadherin_CBD

PCDHAC2 PCDHAC1 PCDHA10 PCDHA7 PCDHA4 PCDHA2

5.52e-08371056IPR031904
DomainCadherin_2

PCDHAC2 PCDHAC1 PCDHA10 PCDHA7 PCDHA4 PCDHA2

1.73e-06651056PF08266
DomainCadherin_N

PCDHAC2 PCDHAC1 PCDHA10 PCDHA7 PCDHA4 PCDHA2

1.73e-06651056IPR013164
DomainTF_Yin_yang

YY2 YY1

3.13e-0521052IPR017114
DomainCadherin_CS

PCDHAC2 PCDHAC1 PCDHA10 PCDHA7 PCDHA4 PCDHA2

3.46e-051091056IPR020894
DomainCADHERIN_1

PCDHAC2 PCDHAC1 PCDHA10 PCDHA7 PCDHA4 PCDHA2

4.25e-051131056PS00232
DomainCadherin

PCDHAC2 PCDHAC1 PCDHA10 PCDHA7 PCDHA4 PCDHA2

4.25e-051131056PF00028
DomainCADHERIN_2

PCDHAC2 PCDHAC1 PCDHA10 PCDHA7 PCDHA4 PCDHA2

4.46e-051141056PS50268
Domain-

PCDHAC2 PCDHAC1 PCDHA10 PCDHA7 PCDHA4 PCDHA2

4.46e-0511410562.60.40.60
DomainCA

PCDHAC2 PCDHAC1 PCDHA10 PCDHA7 PCDHA4 PCDHA2

4.69e-051151056SM00112
DomainCadherin-like

PCDHAC2 PCDHAC1 PCDHA10 PCDHA7 PCDHA4 PCDHA2

4.92e-051161056IPR015919
DomainCadherin

PCDHAC2 PCDHAC1 PCDHA10 PCDHA7 PCDHA4 PCDHA2

5.41e-051181056IPR002126
DomainFtsH

AFG3L2 YME1L1

9.36e-0531052IPR005936
DomainPeptidase_M41

AFG3L2 YME1L1

9.36e-0531052IPR000642
DomainPeptidase_M41

AFG3L2 YME1L1

9.36e-0531052PF01434
DomainPDZ

PARD3B MAST2 SHANK3 AHNAK SCRIB FRMPD3

1.45e-041411056PF00595
DomainPDZ

PARD3B MAST2 SHANK3 AHNAK SCRIB FRMPD3

1.89e-041481056SM00228
Domain-

PARD3B MAST2 SHANK3 AHNAK SCRIB FRMPD3

2.03e-0415010562.30.42.10
DomainAAA

CHTF18 AFG3L2 YME1L1 FIGNL1

2.07e-04521054PF00004
DomainPDZ

PARD3B MAST2 SHANK3 AHNAK SCRIB FRMPD3

2.11e-041511056PS50106
DomainPDZ

PARD3B MAST2 SHANK3 AHNAK SCRIB FRMPD3

2.18e-041521056IPR001478
DomainATPase_AAA_core

CHTF18 AFG3L2 YME1L1 FIGNL1

2.40e-04541054IPR003959
DomainATPase_AAA_CS

AFG3L2 YME1L1 FIGNL1

5.67e-04291053IPR003960
DomainAAA

AFG3L2 YME1L1 FIGNL1

9.10e-04341053PS00674
DomainAAA+_ATPase

CHTF18 AFG3L2 TAP1 YME1L1 FIGNL1

1.32e-031441055IPR003593
DomainAAA

CHTF18 AFG3L2 TAP1 YME1L1 FIGNL1

1.32e-031441055SM00382
DomainCollagen

COL2A1 COL4A6 SCARA5 C1QC

1.35e-03851054IPR008160
DomainCollagen

COL2A1 COL4A6 SCARA5 C1QC

1.35e-03851054PF01391
DomainBAH

TNRC18 BAHCC1

1.67e-03111052SM00439
DomainBAH

TNRC18 BAHCC1

1.67e-03111052PF01426
DomainBAH

TNRC18 BAHCC1

1.67e-03111052PS51038
DomainBAH_dom

TNRC18 BAHCC1

1.67e-03111052IPR001025
DomainCadherin_C

PCDHAC2 PCDHAC1 PCDHA7

1.69e-03421053IPR032455
DomainPkinase_C

CDC42BPA MAST2 PRKCG

1.69e-03421053PF00433
DomainCadherin_C_2

PCDHAC2 PCDHAC1 PCDHA7

1.69e-03421053PF16492
Domainfn3

FNDC4 CMYA5 CSF2RB ROS1 EGFLAM

2.22e-031621055PF00041
DomainAGC-kinase_C

CDC42BPA MAST2 PRKCG

3.86e-03561053IPR000961
DomainAGC_KINASE_CTER

CDC42BPA MAST2 PRKCG

3.86e-03561053PS51285
DomainS_TK_X

CDC42BPA MAST2 PRKCG

3.86e-03561053SM00133
DomainFN3

FNDC4 CMYA5 CSF2RB ROS1 EGFLAM

3.93e-031851055SM00060
DomainFN3

FNDC4 CMYA5 CSF2RB ROS1 EGFLAM

5.34e-031991055PS50853
Domain-

MAP1A ELAC1

5.57e-032010523.60.15.10
DomainMetallo-B-lactamas

MAP1A ELAC1

5.57e-03201052IPR001279
DomainFN3_dom

FNDC4 CMYA5 CSF2RB ROS1 EGFLAM

6.54e-032091055IPR003961
Pubmed

Monoallelic yet combinatorial expression of variable exons of the protocadherin-alpha gene cluster in single neurons.

PCDHAC2 PCDHAC1 PCDHA10 PCDHA7 PCDHA4 PCDHA2

3.60e-1215107615640798
Pubmed

Alpha protocadherins and Pyk2 kinase regulate cortical neuron migration and cytoskeletal dynamics via Rac1 GTPase and WAVE complex in mice.

PCDHAC2 PCDHAC1 PCDHA10 PCDHA7 PCDHA4 PCDHA2

8.86e-1217107629911975
Pubmed

CNR/Pcdhalpha family in subplate neurons, and developing cortical connectivity.

PCDHAC2 PCDHAC1 PCDHA10 PCDHA7 PCDHA4 PCDHA2

1.33e-1118107615570159
Pubmed

Genomic organization of the family of CNR cadherin genes in mice and humans.

PCDHAC2 PCDHAC1 PCDHA10 PCDHA7 PCDHA4 PCDHA2

1.33e-1118107610662547
Pubmed

Developmental epigenetic modification regulates stochastic expression of clustered protocadherin genes, generating single neuron diversity.

PCDHAC2 PCDHAC1 PCDHA10 PCDHA7 PCDHA4 PCDHA2

9.47e-1124107624698270
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

CDC42BPA MRPS12 MUS81 C15orf39 IRS1 BCL9 MAST2 CNTROB NCOR2 URB1 TNRC18 SLC38A10 DST TULP4 AHNAK LRRC56 SNAPC4 MBD5 BAHCC1

1.15e-0911051071935748872
Pubmed

Clustered gamma-protocadherins regulate cortical interneuron programmed cell death.

PCDHAC2 PCDHAC1 PCDHA10 PCDHA7 PCDHA4 PCDHA2

2.35e-0857107632633719
Pubmed

CTCF Governs the Identity and Migration of MGE-Derived Cortical Interneurons.

PCDHAC2 PCDHAC1 PCDHA10 PCDHA7 PCDHA4 PCDHA2

2.62e-0858107630377227
Pubmed

Comparative DNA sequence analysis of mouse and human protocadherin gene clusters.

PCDHAC2 PCDHAC1 PCDHA10 PCDHA7 PCDHA4 PCDHA2

6.90e-0868107611230163
Pubmed

A striking organization of a large family of human neural cadherin-like cell adhesion genes.

PCDHAC2 PCDHAC1 PCDHA10 PCDHA7 PCDHA4 PCDHA2

9.75e-0872107610380929
Pubmed

Cadherin superfamily genes: functions, genomic organization, and neurologic diversity.

PCDHAC2 PCDHAC1 PCDHA10 PCDHA7 PCDHA4 PCDHA2

1.15e-0774107610817752
Pubmed

Phylogenetic analysis of the cadherin superfamily allows identification of six major subfamilies besides several solitary members.

PCDHAC2 PCDHAC1 PCDHA10 PCDHA7 PCDHA4 PCDHA2

1.46e-0777107610835267
Pubmed

Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.

LRATD1 PCDHAC2 PCDHAC1 PCDHA10 PCDHA7 PCDHA4 PCDHA2 IRS1

1.59e-07193107822589738
Pubmed

Large exons encoding multiple ectodomains are a characteristic feature of protocadherin genes.

PCDHAC2 PCDHAC1 PCDHA10 PCDHA7 PCDHA4 PCDHA2

1.84e-0780107610716726
Pubmed

Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.

TNRC6B NBEA SEC31A BCL9 SHANK3 NCOR2 CNTNAP5 DST ZC2HC1A PRKCG ADGRA1 SCRIB FRMPD3 NOP2 TNS1

2.72e-079631071528671696
Pubmed

Interaction with protocadherin-gamma regulates the cell surface expression of protocadherin-alpha.

PCDHA10 PCDHA7 PCDHA4 PCDHA2

1.64e-0628107415347688
Pubmed

A Genome-Wide CRISPR Screen Identifies Genes Critical for Resistance to FLT3 Inhibitor AC220.

PCDHAC2 PCDHAC1 PCDHA10 PCDHA7 PCDHA4 PCDHA2

1.93e-06119107628625976
Pubmed

A human MAP kinase interactome.

CDC42BPA MAP1A CNTRL SREBF2 SEC31A CCDC88B DST ARHGAP31 MBD5 TNS1

2.71e-064861071020936779
Pubmed

Diversity revealed by a novel family of cadherins expressed in neurons at a synaptic complex.

PCDHA10 PCDHA7 PCDHA4

4.59e-061110739655502
Pubmed

KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.

MAP1A WFS1 ZNF185 NBEA SHANK3 NUAK2 RPL10A DST ZC2HC1A UPF2 AFG3L2 C1QC LSM4 PRKCG SCRIB TNS1

7.88e-0614311071637142655
Pubmed

USP7 targets XIAP for cancer progression: Establishment of a p53-independent therapeutic avenue for glioma.

CDC42BPA MAST2 YY1 DST OTOF AHNAK NOP2

8.40e-06234107736243803
Pubmed

Yin Yang 2: the great unknown within the Yin Yang 1 regulatory network.

YY2 YY1

9.38e-062107222248057
Pubmed

The transcription factor YY2 has less momentous properties of an intrinsically disordered protein than its paralog YY1.

YY2 YY1

9.38e-062107231131888
Pubmed

The Forgotten YY2 in Reported YY1 Expression Levels in Human Cancers.

YY2 YY1

9.38e-062107229604937
Pubmed

Homeostasis Imbalance of YY2 and YY1 Promotes Tumor Growth by Manipulating Ferroptosis.

YY2 YY1

9.38e-062107235246964
Pubmed

Genome-wide analysis of YY2 versus YY1 target genes.

YY2 YY1

9.38e-062107220215434
Pubmed

Enhanceosome formation over the beta interferon promoter underlies a remote-control mechanism mediated by YY1 and YY2.

YY2 YY1

9.38e-062107216260628
Pubmed

PDZ-Containing Proteins Targeted by the ACE2 Receptor.

MAST2 SHANK3 SCRIB

1.25e-0515107334835087
Pubmed

Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.

ZNF185 SEC31A RPL10A NCOR2 URB1 DST ZC2HC1A UPF2 CHTF18 AHNAK AFG3L2 SCRIB NOP2 YME1L1 PCMT1

1.72e-0513531071529467282
Pubmed

E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.

NBEA IRS1 AMER3 ZNF831 URB1 SLC38A10 DST AHNAK PLCB3 SCRIB PCMT1

1.74e-057361071129676528
Pubmed

Developmental expression profile of the YY2 gene in mice.

YY2 YY1

2.81e-053107219638226
Pubmed

Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.

SREBF2 C15orf39 MAST2 DST UPF2 CHTF18 AFG3L2 PLCB3 SCRIB FIGNL1

3.35e-056501071038777146
Pubmed

Conserved beta-hairpin recognition by the GYF domains of Smy2 and GIGYF2 in mRNA surveillance and vesicular transport complexes.

TNRC6B SEC31A LSM4

4.79e-0523107320696395
Pubmed

Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.

CDC42BPA NEIL1 MYT1 NUCB2 SREBF2 TNRC6B EVC PARD3B ARHGEF16 NCOR2 TNRC18 TULP4 TECPR2 SDC3 MBD5

5.16e-0514891071528611215
Pubmed

Common variations in 4p locus are related to male completed suicide.

WFS1 EVC

5.60e-054107219115052
Pubmed

Protein kinase C Theta inhibits insulin signaling by phosphorylating IRS1 at Ser(1101).

IRS1 PRKCG

5.60e-054107215364919
Pubmed

Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening.

PCDHA10 PCDHA7 NBEA PCDHA2 SHANK3 URB1 TULP4

7.39e-05329107717474147
Pubmed

The RNA binding protein MEX3A promotes tumor progression of breast cancer by post-transcriptional regulation of IGFBP4.

DDX31 CNTROB TNRC18 DST AHNAK SCRIB NOP2

7.82e-05332107737433992
Pubmed

The DNA sequence and comparative analysis of human chromosome 5.

PCDHA10 PCDHA7 PCDHA4 PCDHA2

8.70e-0575107415372022
Pubmed

Structure and activation of C1, the complex initiating the classical pathway of the complement cascade.

C1QC C1R

9.32e-055107228104818
Pubmed

Expression of recombinant human complement C1q allows identification of the C1r/C1s-binding sites.

C1QC C1R

9.32e-055107223650384
Pubmed

Mint represses transactivation of the type II collagen gene enhancer through interaction with alpha A-crystallin-binding protein 1.

COL2A1 NCOR2

9.32e-055107215778499
Pubmed

PCOLCE2 encodes a functional procollagen C-proteinase enhancer (PCPE2) that is a collagen-binding protein differing in distribution of expression and post-translational modification from the previously described PCPE1.

COL2A1 PCOLCE

9.32e-055107212393877
Pubmed

Common deletion variants causing protocadherin-α deficiency contribute to the complex genetics of BAV and left-sided congenital heart disease.

PCDHA10 PCDHA7

9.32e-055107234888534
Pubmed

The Eyes Absent family members EYA4 and EYA1 promote PLK1 activation and successful mitosis through tyrosine dephosphorylation.

ZNF185 TNRC6B C15orf39 BCL9 NCOR2

1.11e-04152107538360978
Pubmed

Mammalian APE1 controls miRNA processing and its interactome is linked to cancer RNA metabolism.

NEIL1 ZNF185 NUCB2 SREBF2 BBS1 SEC31A ADAM8 CNTROB CHTF18 AHNAK NOP2

1.35e-049251071128986522
Pubmed

Jerky/Earthbound facilitates cell-specific Wnt/Wingless signalling by modulating β-catenin-TCF activity.

BCL9 JRK

1.40e-046107221399610
Pubmed

Rewiring of RSK-PDZ Interactome by Linear Motif Phosphorylation.

PARD3B MAST2 SHANK3

1.58e-0434107330726710
Pubmed

Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes.

MUS81 TNRC6B CNTROB RRP1 DST AHNAK AFG3L2 SCRIB NOP2

1.75e-04645107925281560
Pubmed

Substrate specificities of recombinant mannan-binding lectin-associated serine proteases-1 and -2.

C1QC C1R

1.95e-047107211527969
Pubmed

Deletion of the Isg15 gene results in up-regulation of decidual cell survival genes and down-regulation of adhesion genes: implication for regulation by IL-1beta.

ADAM8 ADGRA1

1.95e-047107220660068
Pubmed

Aurora kinase A regulates Survivin stability through targeting FBXL7 in gastric cancer drug resistance and prognosis.

MYT1 SREBF2 YY1

2.21e-0438107328218735
Pubmed

The G protein-coupled receptor CL1 interacts directly with proteins of the Shank family.

SHANK3 ROS1

2.59e-048107210958799
Pubmed

Appearance and persistence of fibronectin in cartilage. Specific interaction of fibronectin with collagen type II.

COL2A1 COL4A6

2.59e-04810723997552
Pubmed

Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia.

WFS1 IRS1

2.59e-048107219734900
Pubmed

Transforming growth factor-beta and p-21: multiple molecular targets of decorin-mediated suppression of neoplastic growth.

COL2A1 COL4A6

2.59e-048107210382266
Pubmed

Loss-of-function mutations in TBC1D20 cause cataracts and male infertility in blind sterile mice and Warburg micro syndrome in humans.

SEC31A BCL9

2.59e-048107224239381
Pubmed

Optimized fragmentation schemes and data analysis strategies for proteome-wide cross-link identification.

CDC42BPA RPL10A NCOR2 DST UPF2 CHTF18 AHNAK FRMPD3

2.66e-04538107828524877
Pubmed

Targeting TRIM37-driven centrosome dysfunction in 17q23-amplified breast cancer.

MAP1A TNRC6B CNTROB NCOR2 ARHGAP31

2.70e-04184107532908313
Pubmed

The cell proliferation antigen Ki-67 organises heterochromatin.

DDX31 YY1 RPL10A DST CHTF18 JRK SCRIB

2.85e-04410107726949251
Pubmed

Functional proteomic analysis of human nucleolus.

DDX31 RRP1 URB1 NOP2

3.31e-04106107412429849
Pubmed

A central chaperone-like role for 14-3-3 proteins in human cells.

CDC42BPA PARD3B IRS1 MAST2 ARHGEF16 NUAK2 DST AHNAK PRKCG SCRIB

3.32e-048611071036931259
Pubmed

Molecular mechanisms governing Pcdh-gamma gene expression: evidence for a multiple promoter and cis-alternative splicing model.

PCDHAC2 PCDHA4

3.33e-049107212154121
Pubmed

RSPO-LGR4 functions via IQGAP1 to potentiate Wnt signaling.

CDC42BPA URB1 UPF2 SCRIB NOP2

4.14e-04202107524639526
Pubmed

Genes to diseases (G2D) computational method to identify asthma candidate genes.

ADAM8 ADGRA1

4.15e-0410107218682798
Pubmed

Identification of putative retinoic acid target genes downstream of mesenchymal Tbx1 during inner ear development.

COL2A1 MYT1

4.15e-0410107222275070
Pubmed

Human transcription factor protein interaction networks.

DDX31 CDC42BPA MRPS12 YY2 TNRC6B C15orf39 BCL9 YY1 RPL10A NCOR2 DST NOP2 PCMT1

4.52e-0414291071335140242
Pubmed

Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in β-Catenin-Active Cancers.

CDC42BPA WFS1 TNRC6B IRS1 RRP1 RPL10A NCOR2 TNRC18 ZC2HC1A TULP4 CHTF18 AFG3L2

4.62e-0412471071227684187
Pubmed

Proteome analysis of the thalamus and cerebrospinal fluid reveals glycolysis dysfunction and potential biomarkers candidates for schizophrenia.

MAP1A PRKCG PCMT1

4.71e-0449107320471030
Pubmed

Interactome of vertebrate GAF/ThPOK reveals its diverse functions in gene regulation and DNA repair.

SREBF2 YY1 NCOR2 ZC2HC1A NOP2 YME1L1

4.88e-04321107632098917
Pubmed

Disrupted expression of matrix genes in the growth plate of the mouse cartilage matrix deficiency (cmd) mutant.

COL2A1 SDC3

5.06e-041110729664687
Pubmed

Toward simpler and faster genome-wide mutagenesis in mice.

PCDHAC2 PCDHAC1

5.06e-0411107217572674
Pubmed

MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.

CDC42BPA MAP1A MRPS12 TNRC6B SEC31A RRP1 RPL10A DST ZC2HC1A UPF2 PCMT1

5.12e-0410821071138697112
Pubmed

Systems analysis of RhoGEF and RhoGAP regulatory proteins reveals spatially organized RAC1 signalling from integrin adhesions.

CDC42BPA NBEA ARHGEF16 YY1 ARHGAP31 AHNAK LSM4 SCRIB YME1L1 PCMT1

5.38e-049161071032203420
Pubmed

A genome-wide search for loci interacting with known prostate cancer risk-associated genetic variants.

TNRC6B EVC UPF2

5.61e-0452107322219177
Pubmed

N6-Methyladenosine on mRNA facilitates a phase-separated nuclear body that suppresses myeloid leukemic differentiation.

SLC38A10 TECPR2 AHNAK PLCB3 BAHCC1

5.73e-04217107534048709
Pubmed

Proteins of the CNR family are multiple receptors for Reelin.

PCDHA7 PCDHA4

6.07e-0412107210612399
Pubmed

Evc is a positive mediator of Ihh-regulated bone growth that localises at the base of chondrocyte cilia.

COL2A1 EVC

6.07e-0412107217660199
Pubmed

Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB.

CDC42BPA CNTRL TNRC6B NBEA SEC31A DST AHNAK SCRIB NOP2

6.77e-04777107935844135
Pubmed

BioID-based Identification of Skp Cullin F-box (SCF)β-TrCP1/2 E3 Ligase Substrates.

DPCD TNRC6B MAST2 AFG3L2 EGFLAM

6.88e-04226107525900982
Pubmed

Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs.

MAST2 DST MBD5 BAHCC1

7.14e-04130107412421765
Pubmed

Critical role of YY1 in cardiac morphogenesis.

YY1 HAND1

7.15e-0413107225703143
Pubmed

Myocardium-Specific Deletion of Rac1 Causes Ventricular Noncompaction and Outflow Tract Defects.

HAND1 SCRIB

7.15e-0413107233804107
Pubmed

Pikachurin, a dystroglycan ligand, is essential for photoreceptor ribbon synapse formation.

PRKCG EGFLAM

7.15e-0413107218641643
Pubmed

Slc25a17 Gene Trapped Mice: PMP34 Plays a Role in the Peroxisomal Degradation of Phytanic and Pristanic Acid.

ACOX1 SREBF2

7.15e-0413107232266253
Pubmed

A protein interaction landscape of breast cancer.

ZNF185 NUCB2 IRS1 SEC31A RPL10A DST NOP2 YME1L1

7.83e-04634107834591612
Pubmed

Interactome Analysis Reveals Regulator of G Protein Signaling 14 (RGS14) is a Novel Calcium/Calmodulin (Ca2+/CaM) and CaM Kinase II (CaMKII) Binding Partner.

SHANK3 RPL10A ZC2HC1A AFG3L2 PCMT1

7.89e-04233107529518331
Pubmed

The KMT2D Kabuki syndrome histone methylase controls neural crest cell differentiation and facial morphology.

COL2A1 PCOLCE

8.33e-0414107232541010
Pubmed

A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome.

CDC42BPA SEC31A CMYA5 MAST2 DST UPF2 AFG3L2

8.90e-04497107723414517
Pubmed

Fibril treatment changes protein interactions of tau and α-synuclein in human neurons.

NBEA RPL10A DST AHNAK LSM4 SCRIB PCMT1

9.01e-04498107736634849
Pubmed

Transcriptome analysis of mouse stem cells and early embryos.

TNRC6B MAST2 DST TULP4 TNS1 FIGNL1

9.25e-04363107614691545
Pubmed

Proteomic characterization of human multiple myeloma bone marrow extracellular matrix.

COL2A1 COL4A6 C1QC

9.38e-0462107328344315
Pubmed

Prx1 and Prx2 cooperatively regulate the morphogenesis of the medial region of the mandibular process.

COL2A1 HAND1

9.59e-0415107219777594
Pubmed

Conditional ablation of the heparan sulfate-synthesizing enzyme Ext1 leads to dysregulation of bone morphogenic protein signaling and severe skeletal defects.

COL2A1 SDC3

9.59e-0415107220404326
Pubmed

HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation.

COL2A1 DDX31 CDC42BPA MRPS12 WFS1 PCDHAC2 TNRC6B RRP1 UPF2 AHNAK ROS1 NOP2

1.06e-0313711071236244648
Pubmed

Hand transcription factors cooperatively regulate development of the distal midline mesenchyme.

COL2A1 HAND1

1.09e-0316107217764670
Pubmed

The ciliary Evc/Evc2 complex interacts with Smo and controls Hedgehog pathway activity in chondrocytes by regulating Sufu/Gli3 dissociation and Gli3 trafficking in primary cilia.

COL2A1 EVC

1.09e-0316107223026747
Pubmed

The E3-ubiquitin ligase TRIM50 interacts with HDAC6 and p62, and promotes the sequestration and clearance of ubiquitinated proteins into the aggresome.

SEC31A BCL9

1.09e-0316107222792322
Pubmed

The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery.

WFS1 YY2 IRS1 YY1 RRP1 RPL10A NCOR2 AHNAK AFG3L2 NOP2 TAP1

1.21e-0312031071129180619
Pubmed

Combinatorial targeting of a chromatin complex comprising Dot1L, menin and the tyrosine kinase BAZ1B reveals a new therapeutic vulnerability of endocrine therapy-resistant breast cancer.

DDX31 CDC42BPA MUS81 YY1 RRP1 RPL10A URB1 JRK NOP2

1.24e-03847107935850772
InteractionPCDHA10 interactions

PCDHAC1 PCDHA10 PCDHA7 PCDHA4 PCDHA2

8.98e-08221065int:PCDHA10
InteractionPCDHA7 interactions

PCDHA10 PCDHA7 PCDHA4 PCDHA2

6.95e-07141064int:PCDHA7
InteractionTOP3B interactions

CDC42BPA MRPS12 MUS81 TNRC6B C15orf39 IRS1 BCL9 MAST2 CNTROB NCOR2 URB1 TNRC18 SLC38A10 DST UPF2 TULP4 AHNAK LRRC56 LSM4 SNAPC4 MBD5 NOP2 BAHCC1

1.85e-06147010623int:TOP3B
InteractionPCDHA13 interactions

SREBF2 PCDHA10 ZNF786

4.87e-0671063int:PCDHA13
InteractionPCDHA8 interactions

PCDHAC2 PCDHA10 PCDHA7 PCDHA4 PCDHA2

1.03e-05551065int:PCDHA8
InteractionPCDHA9 interactions

PCDHAC2 PCDHA10 PCDHA7 PCDHA4

2.32e-05321064int:PCDHA9
InteractionPCDHA2 interactions

PCDHA10 PCDHA7 PCDHA2

4.94e-05141063int:PCDHA2
Cytoband5q31

PCDHAC2 PCDHAC1 PCDHA10 PCDHA7 PCDHA4 PCDHA2

3.19e-0711510765q31
CytobandEnsembl 112 genes in cytogenetic band chr5q31

PCDHAC2 PCDHAC1 PCDHA10 PCDHA7 PCDHA4 PCDHA2 SOWAHA

6.78e-062981077chr5q31
Cytoband4p16

EVC FGFBP2

7.15e-041710724p16
CytobandXq22

COL4A6 FRMPD3

1.21e-03221072Xq22
GeneFamilyClustered protocadherins

PCDHAC2 PCDHAC1 PCDHA10 PCDHA7 PCDHA4 PCDHA2

2.02e-076472620
GeneFamilyPDZ domain containing

PARD3B MAST2 SHANK3 AHNAK SCRIB FRMPD3

3.16e-051527261220
GeneFamilyAAA ATPases

CHTF18 AFG3L2 YME1L1 FIGNL1

5.84e-0553724413
GeneFamilyAtaxins|Trinucleotide repeat containing

TNRC6B NCOR2 TNRC18

1.31e-0425723775
GeneFamilyFibronectin type III domain containing

FNDC4 CMYA5 CSF2RB ROS1 EGFLAM

4.42e-04160725555
ToppCellfacs-Large_Intestine-Proximal-3m-Epithelial-Brush_cell_of_epithelium_proper_of_large_intestine|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MAP1A NDST4 CMYA5 ZNF831 CCDC88B FGF5

3.51e-06170107617bd7fd25a2657cb536ad47e294332920f759e95
ToppCellStriatum-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)|Striatum / BrainAtlas - Mouse McCarroll V32

AMER3 RRP1 SOWAHA UPF2 OTOF PRKCG

6.26e-061881076e34ea7014c5a059a7db38f78bd903cf02616ddd3
ToppCellStriatum-Neuronal-Excitatory|Striatum / BrainAtlas - Mouse McCarroll V32

AMER3 ZNF831 RRP1 SOWAHA UPF2 PRKCG

7.94e-06196107667400193ba469cf4d939e94f5ed94995e384bc07
ToppCellnucseq-Mesenchymal-Fibroblastic|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

LMCD1 PARD3B DST SCARA5 C1R PCOLCE

7.94e-0619610767d8505dac15fa59935ccf592afc54b04c4c6554f
ToppCellnucseq-Mesenchymal|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

LMCD1 PARD3B DST SCARA5 C1R PCOLCE

8.41e-0619810768f52243ca8b9ba68a75ae411506a3a6de258eb97
ToppCellFibroblasts|World / Immune cells in Rheumatoid Arthritis Joint Synovial Tissues

CDC42BPA MAP1A DST SCARA5 C1R PCOLCE

8.66e-06199107640de6d4a31cf22efa2864f79e4ec8e2b7bfc9d4a
ToppCell3'-GW_trimst-2-LargeIntestine-Mesenchymal|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

MAP1A SCARA5 AHNAK C1R EGFLAM PCOLCE

8.66e-061991076c007cd51577e31553395ceaed70ad447e5854546
ToppCellfacs-Marrow-B-cells-24m-Myeloid|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NUCB2 PCDHA2 CSF2RB ROS1 EGFLAM

2.48e-0514310756df16bf0324661cd9707df69cb39f4b5498d6d49
ToppCellfacs-Trachea-3m-Hematologic-myeloid-tracheal_macrophage-macrophage_of_trachea|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

AMER3 ADAM8 CSF2RB FGF5 ROS1

2.56e-0514410758bd042f12186f36bc5aabf6a0232270a448f4b58
ToppCellprimary_visual_cortex-Neuronal-glutamatergic_neuron-L2/3_IT-L2/3_IT_VISp_Agmat|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

WFS1 LRATD1 EVC ZNF831 OTOF

3.76e-05156107509e0702400570089d9012dcf94dfb4827c97e49d
ToppCellprimary_visual_cortex-Neuronal-glutamatergic_neuron-L2/3_IT-L2/3_IT_VISp_Adamts2|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

WFS1 EVC ZNF831 SOWAHA OTOF

3.76e-0515610752cd007b423c2395c5ce331902e7f27c805755eb3
ToppCellprimary_visual_cortex-Neuronal-glutamatergic_neuron-L2/3_IT|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

WFS1 LRATD1 EVC ZNF831 OTOF

4.37e-051611075e3327c296d48e821004e61a573abb75624a6f040
ToppCellprimary_visual_cortex-Neuronal-glutamatergic_neuron-L6_CT|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

CMYA5 ZNF831 AHNAK FGF5 PRKCG

4.50e-05162107558da6bc04cdac0002b0e6a751c96ff95e1a7f70f
ToppCellprimary_visual_cortex-Neuronal-glutamatergic_neuron-L6_CT-L6_CT_VISp_Ctxn3_Brinp3|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

CMYA5 ARHGAP31 FGF5 PRKCG TNS1

4.63e-051631075b0aa4a620bd58011225b42ea6dda04e3101ba342
ToppCellfacs-MAT-Fat-3m-Myeloid-nan|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADAM8 CCDC88B CSF2RB SDC3 C1QC

4.77e-0516410751250876abd7311f86730e5b9c03c3610cc2ff6d3
ToppCellfacs-MAT-Fat-3m-Myeloid|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADAM8 CCDC88B CSF2RB SDC3 C1QC

4.77e-051641075fa0d77b648cde5e42b9394e877168c80de238bde
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Afferent_/_Efferent_Arteriole_Endothelial_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

LMCD1 SHANK3 ARID5A ARHGAP31 PRKCG

5.05e-051661075ec719368295133da2f7ff587c5329ed6db1dd56d
ToppCellfacs-Lung-EPCAM-24m-Myeloid-Plasmacytoid_Dendritic|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FAM234B NUCB2 CNTROB CSF2RB PRKCG

5.20e-051671075e0f2509e86302eca8352821bce12597f6c51fc24
ToppCellfacs-MAT-Fat-18m-Myeloid-macrophage|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADAM8 CCDC88B CSF2RB OTOF SDC3

5.20e-051671075c2952d8ba763374c5678b92825c8956fc3e3ecd2
ToppCellfacs-Lung-EPCAM-24m-Myeloid-plasmacytoid_dendritic_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FAM234B NUCB2 CNTROB CSF2RB PRKCG

5.20e-051671075b25646b6653cd8814dbeae4c74ce899ede105200
ToppCellCV-Mild-6|CV / Virus stimulation, Condition and Cluster

TNRC6B EFHC2 FRMPD3 MBD5 RIC3

5.20e-051671075cf2ed0b6d17a16f9a2318879ce8856d5983ad3cf
ToppCell3'-GW_trimst-2-LargeIntestine-Neuronal-Glial_immature-Glia_2_(ELN+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

COL2A1 DST FGFBP2 SDC3 C9orf50

5.35e-05168107595dc690c1987b05685d36e6bb20eb79308696e30
ToppCellPND07-Immune-Immune_Myeloid-DC-cDC1-cDC1_prolif|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ADAM8 RPL10A PRKCG ELAC1 FIGNL1

6.14e-05173107528c98a9a54aa2cfa67464db4f628c9357ad185b9
ToppCellBAL-Mild-Epithelial-Epithelial-AT1/AT2|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

LRATD1 MFSD6L ARHGEF16 SOWAHA ADGRA1

6.31e-051741075b7f5492ce8098f7eb0aef30ee558d00738d59d0e
ToppCellBAL-Mild-Epithelial-Epithelial-AT1/AT2-|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

LRATD1 MFSD6L ARHGEF16 SOWAHA ADGRA1

6.31e-05174107571730503be3d9c839c4c9e950145e2101d682a1c
ToppCellBAL-Mild-Epithelial-Epithelial-AT1/AT2|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)

LRATD1 MFSD6L ARHGEF16 SOWAHA ADGRA1

6.31e-051741075ee8ac51fa0b426ad7b7453371bb79c8bf8c1d358
ToppCellBAL-Mild-Epithelial-Epithelial-AT1/AT2-|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

LRATD1 MFSD6L ARHGEF16 SOWAHA ADGRA1

6.31e-051741075cafe4d6b5f08d8888e9db6e196c66df991c03e7b
ToppCell10x3'2.3-week_17-19-Lymphocytic_T-T_NK-Treg|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

NBEA ZNF831 ARHGAP31 C1R RIC3

6.31e-0517410757ca39c9ecd609e5ade30dac1a948a4a4fff1b3b2
ToppCell343B-Myeloid-Dendritic-pDC|Dendritic / Donor, Lineage, Cell class and subclass (all cells)

MAP1A YY2 CSF2RB SCARA5 BAHCC1

6.49e-051751075b30589ff9dc18e745afe61f289e6d576c9c6c6b2
ToppCell10x_3'_v2v3-Non-neoplastic-Myeloid-DC-DC3-B|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

C15orf39 ADAM8 CSF2RB ARHGAP31 PLCB3

6.84e-051771075d34b086a5931d7f1737a504952d51c47693e91a8
ToppCellTCGA-Skin-Metastatic-Melanoma-Skin_Cutaneous_Melanoma-5|TCGA-Skin / Sample_Type by Project: Shred V9

MAP1A MYT1 EFHC2 EGFLAM PCOLCE

7.03e-051781075ad5cd505ca1cef8ac29b2af7e2c3e01ebc140c14
ToppCellfacs-Pancreas-Exocrine-3m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

WFS1 MYT1 IRS1 SEC31A DST

7.03e-051781075fcbbcc44271515de1969b4732b6441c012693d5f
ToppCell3'-Child09-12-SmallIntestine-Epithelial-Tuft-related-Microfold_cell|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

COL2A1 LRATD1 EFHC2 CSF2RB PRKCG

7.22e-051791075c7d7a66fca6a41de0af3cc2b75a29a54456842cd
ToppCellfacs-Marrow-B-cells-18m-Myeloid-CD4+_macrophage|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

WFS1 NUCB2 CMYA5 AHNAK TNS1

7.61e-051811075782716b8b1d447d2bbe09a693fa5ed7ebeac0efb
ToppCellfacs-Marrow-B-cells-18m-Myeloid-macrophage|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

WFS1 NUCB2 CMYA5 AHNAK TNS1

7.61e-051811075e2481291c236105774c53883e6f20da11941df9b
ToppCell3'-Child04-06-SmallIntestine-Mesenchymal-fibroblastic-Stromal_4_(MMP1+)|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

WFS1 FNDC4 CMYA5 C1R PCOLCE

8.01e-051831075269afec240a756eec3bbae5f30ec784281af3433
ToppCell21-Trachea-Mesenchymal-Airway_Smooth_Muscle|Trachea / Age, Tissue, Lineage and Cell class

LMCD1 FNDC4 EVC IRS1 C1R

8.22e-05184107586a96cd88e50eacad1f0badfbbf6dc626f41725e
ToppCellMild_COVID-19-Epithelial-AT1/AT2|Mild_COVID-19 / Disease group,lineage and cell class (2021.01.30)

LRATD1 FNDC4 MFSD6L ARHGEF16 ADGRA1

8.43e-051851075c55fdba1e3818ec0404d7ab473bf18dd25f2bb0a
ToppCellCOVID-19-Epithelial-Ionocytes|COVID-19 / Condition, Lineage and Cell class

LRATD1 MFSD6L IRS1 ARHGEF16 ADGRA1

9.09e-051881075a581cb9528d0febbf3addbb4f6bc140f91a584e6
ToppCellCOVID_vent-Myeloid-Monocytic-SC_&_Eosinophil|COVID_vent / Disease condition, Lineage, Cell class and subclass

CDC42BPA MAP1A SHANK3 EFHC2 DST

9.32e-0518910752157a2d40613f7d5ce2e7dbd266df441e449cdaf
ToppCell10x5'v1-week_14-16-Mesenchymal_fibro-stroma|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

COL2A1 SCARA5 C1R FRMPD3 PCOLCE

9.32e-051891075eccf3d49354a67c94f1ed7c15a98a48a5e8e2ed0
ToppCell10x5'v1-week_14-16-Mesenchymal_fibro|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

COL2A1 SCARA5 C1R FRMPD3 PCOLCE

9.32e-05189107540764f461b8aa1d3a2c5a30590b7fb9307d47d09
ToppCellfacs-Kidney-nan-3m-Epithelial-kidney_loop_of_Henle_ascending_limb_epithelial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FAM234B LRATD1 IRS1 DST PCOLCE

9.56e-05190107568ba1934b2b3f0cec8efd229fe1db6e8be8a26b0
ToppCellfacs-Kidney-nan-3m-Epithelial-kidney_loop_of_Henle_ascending_limb_epithelial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FAM234B LRATD1 IRS1 DST PCOLCE

9.56e-051901075010d7d13a3c16e614c36720ef690a505b9f3f7aa
ToppCellfacs-Thymus-Epithelium-24m-Epithelial|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PCDHAC2 BBS1 SOWAHA DST ZC2HC1A

9.80e-051911075eec14997d2bfc7e6b5a601afc43a147f6b96d668
ToppCellfacs-Thymus-Epithelium-24m-Epithelial-TECs|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PCDHAC2 BBS1 SOWAHA DST ZC2HC1A

9.80e-0519110751730ec5dc1cfd2f0cba7e21555641c7bce97e09d
ToppCell10x5'v1-week_14-16-Mesenchymal_fibro-stroma-arteriolar_fibroblast|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

COL2A1 SCARA5 C1R FRMPD3 PCOLCE

9.80e-0519110755271198116343c07202649889057e5774d7fdde3
ToppCellfacs-Thymus-Epithelium-24m-Epithelial-epithelial_cell_of_thymus|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PCDHAC2 BBS1 SOWAHA DST ZC2HC1A

9.80e-0519110754b77abc68bd72c64e7062f9527fe9d9605289ceb
ToppCellwk_15-18-Epithelial-PNS-FGFBP2+_Neural_progenitor|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

MAP1A MYT1 NBEA FGFBP2 RIC3

1.00e-041921075ab54d4bfc61ef7e3d765afe6e4a6d7011a301ecd
ToppCellTCGA-Prostate-Primary_Tumor-Prostate_Adenocarcinoma-Acinar_Adenocarcinoma-4|TCGA-Prostate / Sample_Type by Project: Shred V9

COL4A6 LMCD1 ARID5A DST C1R

1.08e-0419510755562665dd3beb70e2358aa32611a337bef5731c1
ToppCelldroplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NBEA SEC31A SLC38A10 DST TULP4

1.08e-0419510757796ea9247f4c63762f0de8490fed08b9717fa23
ToppCellfacs-Bladder-nan-3m|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COL4A6 TNRC6B SEC31A SLC38A10 AHNAK

1.11e-04196107544f5b1b474399c9316729155f2ea95a82ca66e30
ToppCellfacs-Bladder-nan-3m-Epithelial|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COL4A6 TNRC6B SEC31A SLC38A10 AHNAK

1.11e-041961075c0e90d964baa2eb4fbd18a52379ccec5d3bf59a8
ToppCell368C|World / Donor, Lineage, Cell class and subclass (all cells)

SCARA5 AHNAK C1QC C1R PCOLCE

1.13e-041971075f41211923938e5d7bfe6bf24f604ab386f17ef10
ToppCellFibroblasts-DKK3+_Fibroblasts|World / Immune cells in Rheumatoid Arthritis Joint Synovial Tissues

CDC42BPA MAP1A SCARA5 FGFBP2 PCOLCE

1.16e-0419810754f4632f26a2043c5e4ab89031b4229b5dca1bd48
ToppCell3'-GW_trimst-1-SmallIntestine-Neuronal-neuron_precursor-Neuroblast|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

COL2A1 MYT1 NBEA DST RIC3

1.16e-041981075c506334d81af672ef9ddc8c4fd2a790bdb58e63e
ToppCell3'-GW_trimst-2-LargeIntestine-Mesenchymal-fibroblastic|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SCARA5 AHNAK C1R EGFLAM PCOLCE

1.16e-041981075d9ffc6589ed510ffa60c591f2a0fe123210f1455
ToppCell3'-GW_trimst-2-LargeIntestine-Mesenchymal-fibroblastic-Stromal_3_(C7+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SCARA5 AHNAK C1R EGFLAM PCOLCE

1.19e-041991075bfc157be6e9f84739848eb19b718de5b17f3fa88
ToppCell356C-Fibroblasts-Fibroblast-F|356C / Donor, Lineage, Cell class and subclass (all cells)

MAP1A LMCD1 SCARA5 C1R PCOLCE

1.19e-04199107559fe5f3c6338e019a149ab135acf9cc5657298bf
ToppCell(09)_Interm._secr.>cil.-(2)_GFP_FOXI1|(09)_Interm._secr.>cil. / shred by cell type by condition

CDC42BPA CNTRL TNRC6B SEC31A YY1

1.19e-041991075fc680f85ebd3bab4c72876a19a461b0afb5f51ce
ToppCellPSB-critical-LOC-Epithelial-Basal|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

COL4A6 CMYA5 DST C1R TNS1

1.19e-0419910752add64c3e4cb6384ec381f34c3f1f77e13e3f27c
ToppCellLPS_anti-TNF-Mesenchymal_myocytic-Myofibroblastic-MatrixFB_->_Myofibroblast|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

LMCD1 IRS1 CMYA5 DST ZC2HC1A

1.19e-04199107538cfd367ee8c074c11ba54edeb7a001e375e2687
ToppCell3'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_1-Adventitial_fibroblasts-Adventitial_fibroblasts_L.2.1.4.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

FNDC4 SCARA5 C1R EGFLAM PCOLCE

1.19e-04199107566b4ff23b2e83fb7e6a37fdafdef315cfa33d327
ToppCellNeuron-Postmitotic-Excitatory_Neuron_-Parietal_and_Temporal-6|World / Primary Cells by Cluster

NBEA RPL10A DST ZC2HC1A RIC3

1.19e-0419910751b1bccf4293f11048709d15a3c892c0edf3da3d2
ToppCell368C-Fibroblasts|368C / Donor, Lineage, Cell class and subclass (all cells)

NUCB2 DST SCARA5 C1R PCOLCE

1.19e-041991075dbf64b83e2dc311b68f299c3f306ee098efd664c
ToppCellTransplant_Alveoli_and_parenchyma-Mesenchymal-Fibroblasts|Mesenchymal / Tissue, Lineage and Cell class of Lung Cells from 10X

MAP1A NUCB2 SCARA5 C1R PCOLCE

1.19e-041991075f19c683f38bca3bfee40396f27423441051dec67
ToppCellNeuron-Postmitotic-Excitatory_Neuron_-Parietal_and_Temporal|World / Primary Cells by Cluster

NBEA RPL10A DST ZC2HC1A RIC3

1.19e-0419910754bee94c116c0da5eba951cb4cea7cc9dcdd6e30f
ToppCell356C-Fibroblasts-Fibroblast-F-|356C / Donor, Lineage, Cell class and subclass (all cells)

MAP1A LMCD1 SCARA5 C1R PCOLCE

1.19e-041991075136f24597ddca5cf2175120975c94782a3232ec6
ToppCellcellseq-Mesenchymal-Fibroblastic|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

LMCD1 DST SCARA5 C1R PCOLCE

1.22e-0420010758978867bf69c830b1e48cac2ad6b512dbe60f149
ToppCell343B-Fibroblasts|343B / Donor, Lineage, Cell class and subclass (all cells)

LMCD1 DST SCARA5 C1R PCOLCE

1.22e-042001075376c1a77031e090be96948b47c78ac0d393f5775
ToppCellParenchyma_Control_(B.)-Stromal-TX-Mesothelial-2|Parenchyma_Control_(B.) / Sample group, Lineage and Cell type

MAP1A NUCB2 SCARA5 C1R PCOLCE

1.22e-042001075b33901d91b3af5c0cf310eede30ce03af90c9783
ToppCellLung_Parenchyma-Control-Mesenchymal-Mesenchymal-Mesothelial-2|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)

MAP1A NUCB2 SCARA5 C1R PCOLCE

1.22e-04200107523bc13983f6bdf95e63109b8bc14c4921ca85c3a
ToppCellParenchymal-10x3prime_v2-Stromal|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

LMCD1 DST SCARA5 C1R PCOLCE

1.22e-042001075f6be0f24e607abb9007823a54fb0b24d04990a89
ToppCellLPS_only-Mesenchymal_myocytic-Myofibroblastic-Myofibroblast|LPS_only / Treatment groups by lineage, cell group, cell type

MAP1A LMCD1 IRS1 DST ZC2HC1A

1.22e-042001075593bf6a7c557437db9a9249a5058a46014179ef6
ToppCellTracheal-10x3prime_v2-Stromal-Peri/Epineurial_|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

CNTROB NCOR2 AHNAK C1R EGFLAM

1.22e-042001075f7c3a8f5ac156c05ad7335d6d142c154c7d86449
ToppCellParenchymal-10x5prime-Stromal-Myofibroblastic-Muscle_perivascular_immune_recruiting|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

LMCD1 FNDC4 C1R EGFLAM PCOLCE

1.22e-04200107538190e4b32f7469df1da7d130bca6d7b12a3dd06
ToppCellLPS_only-Mesenchymal_myocytic-Myofibroblastic-MatrixFB_->_Myofibroblast|LPS_only / Treatment groups by lineage, cell group, cell type

MAP1A LMCD1 NBEA IRS1 ZC2HC1A

1.22e-042001075a9ff3210127000b3dd9e97136163c98c2b0817d7
ToppCellLung_Parenchyma-Control-Mesenchymal-Mesenchymal-Mesothelial-2-|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

MAP1A NUCB2 SCARA5 C1R PCOLCE

1.22e-042001075d276062545ecc428a28b12a74f06f3c6bbcff4a3
ToppCellLPS_only-Mesenchymal_myocytic-Myofibroblastic|LPS_only / Treatment groups by lineage, cell group, cell type

MAP1A LMCD1 IRS1 DST ZC2HC1A

1.22e-04200107502cae2c296a13ad4cbb53bca7a86d64629d67d66
ToppCellSigmoid-T_cell-Tfh|T_cell / Region, Cell class and subclass

FAM234B NUCB2 ARID5A C1QC RIC3

1.22e-042001075dd7dcf25520f065bf0d33d589f3c176f63875dc9
ToppCellEntopeduncular-Neuronal-Excitatory-eN1(Slc17a7)-eN1_1-Excitatory_Neuron.Slc17a7.Zbtb20_(Ventral_Hippocampus)|Entopeduncular / BrainAtlas - Mouse McCarroll V32

ZNF831 CCDC88B FGF5 PRKCG

1.44e-041101074ff196c71aa2a21cdd812958bd163fa6b91bd2352
ToppCellEntopeduncular-Neuronal-Excitatory-eN1(Slc17a7)-eN1_1|Entopeduncular / BrainAtlas - Mouse McCarroll V32

ZNF831 CCDC88B FGF5 PRKCG

1.44e-041101074438bf761ab0a25e3dc9244c23ae2c2d68a169c7f
ToppCellEntopeduncular-Neuronal-Excitatory-eN1(Slc17a7)-eN1_1-Excitatory_Neuron.Slc17a7.Zbtb20_(Ventral_Hippocampus)-|Entopeduncular / BrainAtlas - Mouse McCarroll V32

ZNF831 CCDC88B FGF5 PRKCG

1.44e-04110107446635a130453c2fa304f0e09561b2a267c9ceb31
ToppCellEntopeduncular-Neuronal-Excitatory-eN1(Slc17a7)|Entopeduncular / BrainAtlas - Mouse McCarroll V32

ZNF831 CCDC88B FGF5 PRKCG

1.44e-0411010743639fb5fc02eca509cb220295bc3e6064c23baab
DrugEthaverine hydrochloride [985-13-7]; Down 200; 9.2uM; PC3; HT_HG-U133A

DDX31 MYT1 C15orf39 MAST2 NCOR2 FGF5 TNS1 PCOLCE

4.27e-0619710786737_DN
DrugHarmaline hydrochloride dihydrate [6027-98-1]; Down 200; 14uM; PC3; HT_HG-U133A

COL2A1 FAM234B CDC42BPA MAP1A NCOR2 URB1 FGF5 TNS1

4.27e-0619710786623_DN
DrugMethiothepin maleate [19728-88-2]; Down 200; 8.4uM; PC3; HT_HG-U133A

FAM234B CDC42BPA MAP1A SREBF2 TNRC6B SDC3 FGF5 TNS1

4.60e-0619910786312_DN
Drug17-AAG; Down 200; 1uM; MCF7; HT_HG-U133A

FAM234B C15orf39 BCL9 MAST2 ARHGEF16 SNAPC4 BAHCC1

2.75e-0518510775585_DN
DrugLY 294002; Down 200; 10uM; PC3; HT_HG-U133A

COL2A1 MRPS12 ARHGEF16 YY1 NOP2 TNS1 PCOLCE

3.37e-0519110774451_DN
Drugthioridazine hydrochloride; Down 200; 10uM; PC3; HT_HG-U133A

COL2A1 CNTRL YY1 URB1 TNS1 BAHCC1 PCOLCE

3.37e-0519110774454_DN
DrugRapamycin; Down 200; 0.1uM; PC3; HT_HG-U133A

DDX31 MRPS12 EVC ARHGEF16 SNAPC4 NOP2 TNS1

3.60e-0519310774431_DN
DrugAC1L1KEH

IRS1 PRKCG PLCB3 TAP1

3.70e-05401074CID000005462
Drugradicicol, diheterospora chlamydosporia; Down 200; 0.1uM; HL60; HT_HG-U133A

DDX31 MRPS12 MAST2 YY1 RRP1 URB1 BAHCC1

3.84e-0519510771160_DN
DrugOfloxacin [82419-36-1]; Up 200; 11uM; PC3; HT_HG-U133A

COL4A6 DDX31 CNTRL C15orf39 YY1 NCOR2 PCOLCE

3.84e-0519510777372_UP
DrugGossypol [303-45-7]; Down 200; 7.8uM; PC3; HT_HG-U133A

COL4A6 TNRC6B ARHGEF16 YY1 FGF5 SNAPC4 TNS1

3.97e-0519610774296_DN
DrugDienestrol [84-17-3]; Down 200; 15uM; PC3; HT_HG-U133A

FAM234B MAP1A MRPS12 CNTRL NUAK2 SNAPC4 BAHCC1

4.23e-0519810775727_DN
DrugProtoveratrine A [143-57-7]; Down 200; 5uM; PC3; HT_HG-U133A

MRPS12 LMCD1 CNTRL URB1 SNAPC4 TNS1 BAHCC1

4.37e-0519910776618_DN
DrugTinidazole [19387-91-8]; Down 200; 16.2uM; MCF7; HT_HG-U133A

RETREG2 LMCD1 SREBF2 BCL9 ARHGEF16 ADAM8 SNAPC4

4.37e-0519910773430_DN
DrugBetaxolol hydrochloride [63659-19-8]; Down 200; 11.6uM; HL60; HG-U133A

RETREG2 ACOX1 TNRC6B MAST2 ARID5A RRP1 SNAPC4

4.51e-0520010771592_DN
DrugSuramin sodium salt; Up 200; 10uM; PC3; HT_HG-U133A

COL4A6 DDX31 CDC42BPA MRPS12 NEIL1 CNTRL AHNAK

4.51e-0520010777501_UP
Diseasevisceral adipose tissue measurement, body mass index

LRATD1 PCDHAC2 PCDHAC1 PCDHA10 PCDHA7 PCDHA4 PCDHA2

2.39e-08871037EFO_0004340, EFO_0004765
Disease1,5 anhydroglucitol measurement

PCDHAC1 PCDHA10 PCDHA7 PCDHA4 PCDHA2

5.22e-08291035EFO_0008009
Diseasepulse pressure measurement

COL2A1 ACOX1 MYT1 CNTRL NUCB2 PCDHAC1 TNRC6B PCDHA10 PCDHA7 PCDHA4 NBEA PCDHA2 ZNF831 MAST2 YY1 ARID5A FGF5 MBD5

1.45e-06139210318EFO_0005763
Diseasehypertension, pregnancy-induced

ZNF831 FGF5

1.20e-0451032MONDO_0024664
Diseaseneutrophil count, basophil count

PCDHA10 PCDHA7 PCDHA4 PCDHA2 MAST2 ZNF786

1.39e-042241036EFO_0004833, EFO_0005090
Diseasepost-traumatic stress disorder symptom measurement

PCDHA7 PCDHA4 NBEA PCDHA2

1.99e-04821034EFO_0008535
DiseaseInsulin Sensitivity

NEIL1 SREBF2 IRS1

1.22e-03601033C0920563
Diseaseresponse to antipsychotic drug

NBEA ZNF831 CNTNAP5

1.22e-03601033GO_0097332
DiseaseInsulin Resistance

NEIL1 SREBF2 IRS1

1.22e-03601033C0021655
Diseasepreeclampsia, hypertension, pregnancy-induced

ZNF831 FGF5

1.40e-03161032EFO_0000668, MONDO_0024664
Diseasepreeclampsia, parental genotype effect measurement

ZNF831 FGF5

1.40e-03161032EFO_0000668, EFO_0005939
DiseaseLipidemias

NEIL1 IRS1

1.59e-03171032C1706412
DiseaseHyperlipidemia

NEIL1 IRS1

1.59e-03171032C0020473
Diseaseautism spectrum disorder (implicated_via_orthology)

NDST4 NBEA SHANK3 CNTNAP5

2.02e-031521034DOID:0060041 (implicated_via_orthology)
Diseaseosteoarthritis, knee

COL2A1 NEIL1 NDST4 PARD3B

2.32e-031581034EFO_0004616
DiseaseAbnormality of refraction

PCDHAC1 EVC PCDHA10 PCDHA7 PCDHA4 NBEA PCDHA2 CNTNAP5

2.50e-036731038HP_0000539
DiseaseQT interval

CDC42BPA MAST2 FGFBP2 FGF5 HAND1 ROS1 MBD5

2.72e-035341037EFO_0004682
DiseaseSensorineural Hearing Loss (disorder)

COL2A1 YME1L1

2.91e-03231032C0018784
Diseaseautoimmune disease

CCDC88B ARHGAP31 LSM4 TAP1

3.21e-031731034EFO_0005140
Diseasetype 1 diabetes mellitus (is_implicated_in)

WFS1 SREBF2 TAP1

3.32e-03851033DOID:9744 (is_implicated_in)

Protein segments in the cluster

PeptideGeneStartEntry
PNKGAQLDPKGGPAA

AMER3

66

Q8N944
ILNRKGPQEVGPQGP

CHTF18

451

Q8WVB6
APGQRPPGALGKKKA

BAHCC1

1741

Q9P281
LKDGVLLGPPGKEGL

ARID5A

366

Q03989
LRPGAQDLAPKGLPG

C9orf50

6

Q5SZB4
KGPPGSIVKKGLPGL

COL4A6

851

Q14031
PVRKPRPGQQDGKEG

CNTRL

1176

Q7Z7A1
KPGKVGPPLDIKLGA

EGFLAM

31

Q63HQ2
RQGPAGLGPKKRAEP

CCDC88B

956

A6NC98
LGAKIPKGAILTGPP

AFG3L2

336

Q9Y4W6
PFGGPSQNGLPKGKL

ADGRA1

521

Q86SQ6
KIEPSELPLPGGGNR

ARHGEF16

561

Q5VV41
PDVNIEGPEGKLKGP

AHNAK

2551

Q09666
PDVNIEGPEGKLKGP

AHNAK

4431

Q09666
PHPGNVLVRKGPDGK

ADCK5

361

Q3MIX3
GPAEGAVGPKVALKP

ADAM8

796

P78325
QLGSPLGNPPGKKEF

C1R

91

P00736
DIKDIVGPKGPPGPQ

COL2A1

111

P02458
GQGPGPKRGTEPKVK

PCOLCE

281

Q15113
PGNPKQSGPGELPDK

PCDHA2

871

Q9Y5H9
GNPKQSGPGELPDKF

PCDHA7

861

Q9UN72
GELRPKQPGPVKLGG

NCOR2

2081

Q9Y618
GPGPIFVKNILPKGA

PARD3B

406

Q8TEW8
NLGIPKPFGPQIKGT

PADI6

626

Q6TGC4
ILGKFVPPIPKQDGG

FIGNL1

336

Q6PIW4
GLRTLPQEPGKPQKD

MAP1A

1121

P78559
FQGDPGPLAPKGRKS

NEIL1

281

Q96FI4
PKGTPIQGSKLRLPG

DST

7441

Q03001
VKTALPLLPGGKGPG

MFSD6L

206

Q8IWD5
PGIGGEPLLGQKIKP

EFHC2

41

Q5JST6
PEGGAVPGPKQGKDR

JRK

201

O75564
GVKNGKSPLGEAPEP

FAM234B

46

A2RU67
TQPGPRPGGNEEAKK

FGFBP2

186

Q9BYJ0
ERGQPDKFGVKAPPG

LRATD1

46

Q96KN4
GFPPALGPVEKRIKG

HAND1

186

O96004
PGAGKGPQTDDPRNK

PRKCG

86

P05129
GKRQEPPPTPEGKLG

RIC3

31

Q7Z5B4
APGKGDIPPLTDNGK

NDST4

111

Q9H3R1
KVKKQNAPGEPGGRP

DDX31

801

Q9H8H2
LRPGELGGAPKEPAK

IRS1

1151

P35568
LQQGIPPSGPAGELK

NUCB2

401

P80303
LPGQGGLPKEEGKQQ

LMCD1

201

Q9NZU5
PGNPKQSGPGELPDK

PCDHA10

871

Q9Y5I2
PGNPKQSGPGELPDK

PCDHAC1

886

Q9H158
GNPKQSGPGELPDKF

PCDHAC2

931

Q9Y5I4
GNPKQSGPGELPDKF

PCDHA4

871

Q9UN74
PKDPKIREVLGFGGP

PLCB3

81

Q01970
HGEKRLAPKGQPGPA

FGF5

21

P12034
GIPAIPGIRGPKGQK

C1QC

61

P02747
KPLPGITVGDIGPKF

ACOX1

216

Q15067
PPALGPRVGGQDQKD

CSF2RB

676

P32927
KDPGGKSCRLQGPPV

DCDC2B

96

A2VCK2
KLQEQLGPRKGGKPG

FRMPD3

651

Q5JV73
KGKGPEQSPQGRPVG

FNDC4

206

Q9H6D8
NPGVLDGPQKKPEGP

BCL9

391

O00512
FKKGGNQEIGPLPPT

CMYA5

1761

Q8N3K9
PAPLGAGNLGPELIK

DPCD

71

Q9BVM2
KGALPGKGVLQPAPS

MAST2

1461

Q6P0Q8
PKPGPDLLRKQGQGS

MBD5

681

Q9P267
PGTGRGQPEKKPGRQ

LSM4

121

Q9Y4Z0
LQVKPLNGSPGPKDG

LLCFC1

21

Q96L11
KKPLPQERGDLGVPN

EVC

936

P57679
PQEVPPGNKLAGLEG

ETV2

11

O00321
PGGQQPRLKVLKGPL

BBS1

61

Q8NFJ9
PKGARPGPGLLDNAI

SDC3

351

O75056
ISLAKGPPGPKGDQG

SCARA5

301

Q6ZMJ2
PEPELGLKRAVPGGQ

SLC38A10

1016

Q9HBR0
GIPVPGKPGTFLKKN

CNTNAP5

311

Q8WYK1
PDGEGLLKQGLPPAQ

CNTROB

691

Q8N137
QIGPAGKADLPPING

OTOF

1096

Q9HC10
LKSQLRKGPPLGGGE

UPF2

1146

Q9HAU5
DQLKPGGRLILPVGP

PCMT1

171

P22061
IKKGNGLPPLDCPRG

LRRC56

256

Q8IYG6
GITPKGLDGPRPSQK

NBEA

661

Q8NFP9
RKRQGKNAPPGGDEP

RETREG2

261

Q8NC44
QPTGGQLLLDGKPLP

TAP1

556

Q03518
QQERGKGEKEPPSPG

RRP1

371

P56182
LSPEGPGKEKELPGQ

SCRIB

1231

Q14160
GDPKEQKPPQASGLL

NUAK2

481

Q9H093
KPLPGKLPKGISAGA

NOP2

71

P46087
PEQTKGPLGIDPQKG

CDC42BPA

1066

Q5VT25
KAQLKDPQGPGPGLE

URB1

36

O60287
PRKLGPTEGRPQLKG

MRPS12

46

O15235
PGLKKIDTEAPGLPG

C15orf39

616

Q6ZRI6
PAGLLRPKKGLGEPG

TNRC18

1926

O15417
RAPLQPLAKSKGGPG

TULP4

1006

Q9NRJ4
QGLPGPEKLPGSLRK

SHANK3

761

Q9BYB0
AEPGPGAAKGPPQQK

SOWAHA

201

Q2M3V2
TGKKLPPGGIPGIDL

YY1

256

P25490
VPGGVKQLEPPKEGE

SREBF2

316

Q12772
PGGLPGIDLSDPKQL

YY2

221

O15391
TGPRGVKLKGCPNEP

TNS1

1531

Q9HBL0
GVPNKPGIPKLLEGS

ROS1

1751

P08922
GLLPPGLQATPELGK

TECPR2

421

O15040
SGLKGAEAPPNQKGP

ARHGAP31

1011

Q2M1Z3
NAQKLKDLGVPPGPA

ELAC1

201

Q9H777
PRILGPGLNKAGKFP

RPL10A

121

P62906
LPKGILLVGPPGTGK

YME1L1

371

Q96TA2
GLDQALKEGGKLPPP

ZC2HC1A

96

Q96GY0
LKEGIPGPRNLDLPG

ZNF786

161

Q8N393
GLEKLPLRQPGPEKG

SNAPC4

1236

Q5SXM2
NDVPLPPGKGLDLGL

ZNF831

1431

Q5JPB2
KQQLPKGRPGPVAGH

SEC31A

806

O94979
LGGRTKGKPLPPGEE

ZNF185

6

O15231
NVGLPDLQTKGPIPG

TNRC6B

1356

Q9UPQ9
DGGAQPGPVPKSLQK

WFS1

211

O76024
GLSLLNVGIGPKEPP

MUS81

221

Q96NY9
PPAEQSQLGLGEPGK

MYT1

401

Q01538