Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyCellularComponent	spectrin-associated cytoskeleton	ANK3 SPTBN1 SPTBN2	4.59e-05	9	174	3	GO:0014731
GeneOntologyCellularComponent	spectrin	SPTBN1 SPTBN2 SPTBN5	4.59e-05	9	174	3	GO:0008091
Domain	WD40	NBEAL1 EML6 PEX7 WRAP53 NEDD1 DCAF5 RFWD3 FZR1 RPTOR TBL1X WDR48	2.61e-05	259	170	11	PF00400
Domain	CH	SPTBN1 SPTBN2 GAS2 SPTBN5 CLMN IQGAP3	2.76e-05	65	170	6	SM00033
Domain	WD40	NBEAL1 EML6 PEX7 WRAP53 NEDD1 DCAF5 RFWD3 FZR1 RPTOR TBL1X WDR48	3.57e-05	268	170	11	SM00320
Domain	WD40_repeat	NBEAL1 EML6 PEX7 WRAP53 NEDD1 DCAF5 RFWD3 FZR1 RPTOR TBL1X WDR48	4.09e-05	272	170	11	IPR001680
Domain	CH	SPTBN1 SPTBN2 GAS2 SPTBN5 CLMN IQGAP3	4.22e-05	70	170	6	PF00307
Domain	-	SPTBN1 SPTBN2 GAS2 SPTBN5 CLMN IQGAP3	4.57e-05	71	170	6	1.10.418.10
Domain	WD_REPEATS_1	NBEAL1 EML6 PEX7 WRAP53 NEDD1 DCAF5 RFWD3 FZR1 RPTOR TBL1X WDR48	4.98e-05	278	170	11	PS00678
Domain	ACTININ_2	SPTBN1 SPTBN2 SPTBN5 CLMN	5.13e-05	23	170	4	PS00020
Domain	ACTININ_1	SPTBN1 SPTBN2 SPTBN5 CLMN	5.13e-05	23	170	4	PS00019
Domain	Actinin_actin-bd_CS	SPTBN1 SPTBN2 SPTBN5 CLMN	5.13e-05	23	170	4	IPR001589
Domain	WD_REPEATS_2	NBEAL1 EML6 PEX7 WRAP53 NEDD1 DCAF5 RFWD3 FZR1 RPTOR TBL1X WDR48	5.14e-05	279	170	11	PS50082
Domain	WD_REPEATS_REGION	NBEAL1 EML6 PEX7 WRAP53 NEDD1 DCAF5 RFWD3 FZR1 RPTOR TBL1X WDR48	5.14e-05	279	170	11	PS50294
Domain	CH	SPTBN1 SPTBN2 GAS2 SPTBN5 CLMN IQGAP3	5.35e-05	73	170	6	PS50021
Domain	PH_dom-spectrin-type	SPTBN1 SPTBN2 SPTBN5	5.98e-05	9	170	3	IPR001605
Domain	CH-domain	SPTBN1 SPTBN2 GAS2 SPTBN5 CLMN IQGAP3	6.24e-05	75	170	6	IPR001715
Domain	WD40_repeat_dom	NBEAL1 EML6 PEX7 WRAP53 NEDD1 DCAF5 RFWD3 FZR1 RPTOR TBL1X WDR48	9.00e-05	297	170	11	IPR017986
Domain	-	NBEAL1 EML6 PEX7 WRAP53 NEDD1 DCAF5 RFWD3 FZR1 RPTOR TBL1X WDR48	2.44e-04	333	170	11	2.130.10.10
Domain	WD40/YVTN_repeat-like_dom	NBEAL1 EML6 PEX7 WRAP53 NEDD1 DCAF5 RFWD3 FZR1 RPTOR TBL1X WDR48	2.57e-04	335	170	11	IPR015943
Domain	ARM-type_fold	SMG1 NBEAL1 RNPEPL1 DOCK9 RICTOR HEATR5A BTAF1 TRIP12 VIRMA RPTOR BRAT1	2.84e-04	339	170	11	IPR016024
Domain	N2O_reductase_N	PEX7 FZR1 TBL1X	3.11e-04	15	170	3	IPR011045
Domain	Spectrin_bsu	SPTBN1 SPTBN2	4.88e-04	4	170	2	IPR016343
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	TANC2 EPPK1 ESYT1 POLE PIEZO1 RNPEPL1 DOCK9 NAGLU MYOM3 BTAF1 WRAP53 POM121C HDAC7 C2CD2 ST14 KIAA2013 FZR1 MDN1 PROM2 RPTOR CHD5 NLRC5 PLA2G6 CABIN1 BRAT1 MMP17 IQGAP3 TRAPPC9	2.32e-12	1105	176	28	35748872
Pubmed	Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.	SMG1 RNGTT ESYT1 NOL6 RICTOR POM121C TRIP12 TRIP10 POM121 UBR5 AIFM1 SUPT6H NUFIP2 NXF1 PML	8.39e-09	440	176	15	34244565
Pubmed	RNF43 inhibits WNT5A-driven signaling and suppresses melanoma invasion and resistance to the targeted therapy.	ANK3 ESYT1 NEDD1 POM121C POM121 MEIOC NUFIP2 SECISBP2 PEAK1 PLEKHA7	1.04e-06	263	176	10	34702444
Pubmed	LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.	DAGLB ESYT1 POLE BTAF1 POM121C TRIP12 KIAA2013 ARL6IP6 POM121 CEP78 UBR5 COG1 RPTOR NUFIP2 CSTF3 BRAT1 IQGAP3 QSOX2	1.58e-06	942	176	18	31073040
Pubmed	TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.	TANC2 SMG1 POLE NOL6 ADCK2 PDCD7 POM121C VIRMA DNAH7 RHEB MDN1 GYS1 PHACTR3 PRDX5	5.14e-06	638	176	14	31182584
Pubmed	Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.	TANC2 KCNH7 ANK3 SCAMP1 DOCK9 SPTBN1 ATG2B RICTOR SHROOM2 RHEB NSFL1C AJM1 RPTOR NUFIP2 PRICKLE2 KNDC1 ASTN1 PEAK1 PRDX5	5.74e-06	1139	176	19	36417873
Pubmed	E-cadherin interactome complexity and robustness resolved by quantitative proteomics.	ISYNA1 ANK3 ARHGAP23 ESYT1 DOCK9 SPTBN1 SPTBN2 GPRC5A NSFL1C PROM2 CLMN PEAK1 PLEKHA7	6.82e-06	565	176	13	25468996
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	MBLAC2 ANK3 FOLH1 FBXL17 BTAF1 ADGRV1 NEDD1 SHROOM2 PLBD2 C2CD2 TTC19 PROM2 CLMN SUPT6H RPTOR KNDC1 NLRC5 CSTF3 PLA2G6 SPIDR TRAPPC9 TBL1X	6.99e-06	1489	176	22	28611215
Pubmed	Rheb activates mTOR by antagonizing its endogenous inhibitor, FKBP38.	RICTOR RHEB RPTOR	7.00e-06	8	176	3	17991864
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	TANC2 ARHGAP23 SPTBN2 RICTOR POM121C GALNT16 KIAA2013 MYO15B POM121 SPIDR PEAK1 TRAPPC9	8.89e-06	493	176	12	15368895
Pubmed	Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro.	HEATR5A VIRMA COG1 RPTOR CHD5 NUFIP2 CC2D2A	1.37e-05	153	176	7	10718198
Pubmed	Cell organization, growth, and neural and cardiac development require αII-spectrin.	ANK3 SPTBN1 SPTBN2	1.49e-05	10	176	3	22159418
Pubmed	Structure of S6 kinase 1 determines whether raptor-mTOR or rictor-mTOR phosphorylates its hydrophobic motif site.	RICTOR RHEB RPTOR	1.49e-05	10	176	3	15809305
Pubmed	KAP1 facilitates reinstatement of heterochromatin after DNA replication.	EPPK1 POLE RPS8 NOL6 TRIP12 VIRMA TRIP10 UBR5 GYS1 FDXR PRPF39 IQGAP3 NXF1 LCMT1	1.55e-05	704	176	14	29955894
Pubmed	CTDP1 regulates breast cancer survival and DNA repair through BRCT-specific interactions with FANCI.	RNGTT RICTOR BTAF1 SHROOM2 MDN1 UBR5	1.55e-05	104	176	6	31240132
Pubmed	Tti1 and Tel2 are critical factors in mammalian target of rapamycin complex assembly.	SMG1 RICTOR RPTOR	2.04e-05	11	176	3	20427287
Pubmed	mTOR Directs Breast Morphogenesis through the PKC-alpha-Rac1 Signaling Axis.	RICTOR RPTOR	2.55e-05	2	176	2	26132202
Pubmed	Sirtuin-1 Controls Poly (I:C)-Dependent Matrix Metalloproteinase 9 Activation in Primary Human Nasal Epithelial Cells.	SIRT1 MMP9	2.55e-05	2	176	2	29767533
Pubmed	Raptor directs Sertoli cell cytoskeletal organization and polarity in the mouse testis.	RHEB RPTOR	2.55e-05	2	176	2	29961810
Pubmed	The angiostatic molecule Multimerin 2 is processed by MMP-9 to allow sprouting angiogenesis.	MMRN2 MMP9	2.55e-05	2	176	2	28435016
Pubmed	VIRMA promotes the progression of head and neck squamous cell carcinoma by regulating UBR5 mRNA and m6A levels.	VIRMA UBR5	2.55e-05	2	176	2	38577917
Pubmed	Infiltration of inflammatory cells plays an important role in matrix metalloproteinase expression and activation in the heart during sepsis.	MMP9 NOS2	2.55e-05	2	176	2	17071581
Pubmed	Hypoxia-inducible factors in CD4+ T cells promote metabolism, switch cytokine secretion, and T cell help in humoral immunity.	RICTOR RPTOR	2.55e-05	2	176	2	30988188
Pubmed	Human cytomegalovirus infection alters the substrate specificities and rapamycin sensitivities of raptor- and rictor-containing complexes.	RICTOR RPTOR	2.55e-05	2	176	2	16959881
Pubmed	Regulation of endothelial cell proliferation and vascular assembly through distinct mTORC2 signaling pathways.	RICTOR RPTOR	2.55e-05	2	176	2	25582201
Pubmed	Caspase-3/7-mediated Cleavage of β2-spectrin is Required for Acetaminophen-induced Liver Damage.	SPTBN1 SPTBN2	2.55e-05	2	176	2	26884715
Pubmed	Inducible nitric oxide synthase deficiency impairs matrix metalloproteinase-9 activity and disrupts leukocyte migration in hepatic ischemia/reperfusion injury.	MMP9 NOS2	2.55e-05	2	176	2	19443702
Pubmed	IQGAP3 interacts with Rad17 to recruit the Mre11-Rad50-Nbs1 complex and contributes to radioresistance in lung cancer.	IQGAP3 RAD17	2.55e-05	2	176	2	32896617
Pubmed	Adipocyte mTORC1 deficiency promotes adipose tissue inflammation and NLRP3 inflammasome activation via oxidative stress and de novo ceramide synthesis.	RICTOR RPTOR	2.55e-05	2	176	2	28679588
Pubmed	Inflammatory stimuli induce inhibitory S-nitrosylation of the deacetylase SIRT1 to increase acetylation and activation of p53 and p65.	SIRT1 NOS2	2.55e-05	2	176	2	25389371
Pubmed	A critical role for Rictor in T lymphopoiesis.	RICTOR RPTOR	2.55e-05	2	176	2	22815285
Pubmed	Novel role for calcium-independent phospholipase A(2) in the macrophage antiviral response of inducible nitric-oxide synthase expression.	PLA2G6 NOS2	2.55e-05	2	176	2	12167650
Pubmed	A hedgehog-induced BTB protein modulates hedgehog signaling by degrading Ci/Gli transcription factor.	SPOPL SPOP	2.55e-05	2	176	2	16740475
Pubmed	Raptor and rictor expression in patients with human papillomavirus-related oropharyngeal squamous cell carcinoma.	RICTOR RPTOR	2.55e-05	2	176	2	33482765
Pubmed	Different Role of Raptor and Rictor in Regulating Rasfonin-Induced Autophagy and Apoptosis in Renal Carcinoma Cells.	RICTOR RPTOR	2.55e-05	2	176	2	33155352
Pubmed	A protein deacetylase SIRT1 is a negative regulator of metalloproteinase-9.	SIRT1 MMP9	2.55e-05	2	176	2	19376817
Pubmed	Ankyrin-G and beta2-spectrin collaborate in biogenesis of lateral membrane of human bronchial epithelial cells.	ANK3 SPTBN1	2.55e-05	2	176	2	17074766
Pubmed	Evolutionary expansion of SPOP and associated TD/POZ gene family: impact of evolutionary route on gene expression pattern.	SPOPL SPOP	2.55e-05	2	176	2	20399258
Pubmed	Active modulation of human erythrocyte mechanics.	PIEZO1 NOS2	2.55e-05	2	176	2	32579474
Pubmed	Genetic and pharmacologic evidence that calcium-independent phospholipase A2beta regulates virus-induced inducible nitric-oxide synthase expression by macrophages.	PLA2G6 NOS2	2.55e-05	2	176	2	15946940
Pubmed	Negative regulation of stress-induced matrix metalloproteinase-9 by Sirt1 in skin tissue.	SIRT1 MMP9	2.55e-05	2	176	2	20812964
Pubmed	Serine protease activity contributes to control of Mycobacterium tuberculosis in hypoxic lung granulomas in mice.	SPOP NOS2	2.55e-05	2	176	2	20679732
Pubmed	SET7/9 Enzyme Regulates Cytokine-induced Expression of Inducible Nitric-oxide Synthase through Methylation of Lysine 4 at Histone 3 in the Islet β Cell.	SETD7 NOS2	2.55e-05	2	176	2	25995453
Pubmed	mTOR activity and its prognostic significance in human colorectal carcinoma depending on C1 and C2 complex-related protein expression.	RICTOR RPTOR	2.55e-05	2	176	2	27729429
Pubmed	Hypoxia enhances gene expression of inducible nitric oxide synthase and matrix metalloproteinase-9 in ras/myc-transformed serum-free mouse embryo cells under simulated inflammatory and infectious conditions.	MMP9 NOS2	2.55e-05	2	176	2	18474440
Pubmed	2-Deoxy glucose regulate MMP-9 in a SIRT-1 dependent and NFkB independent mechanism.	SIRT1 MMP9	2.55e-05	2	176	2	27704463
Pubmed	mTORC1 loss impairs epidermal adhesion via TGF-β/Rho kinase activation.	RHEB RPTOR	2.55e-05	2	176	2	28945203
Pubmed	Expression of Raptor and Rictor and their relationships with angiogenesis in colorectal cancer.	RICTOR RPTOR	2.55e-05	2	176	2	32039630
Pubmed	Roadkill attenuates Hedgehog responses through degradation of Cubitus interruptus.	SPOPL SPOP	2.55e-05	2	176	2	16651542
Pubmed	alphaII-betaV spectrin bridges the plasma membrane and cortical lattice in the lateral wall of the auditory outer hair cells.	SPTBN1 SPTBN2 SPTBN5	3.51e-05	13	176	3	18796539
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	TANC2 ESYT1 SPTBN1 RICTOR TRIP12 VIRMA DNAH7 HDAC7 MDN1 CLMN RPTOR PEAK1 PLEKHA7 TRAPPC9 PML	3.54e-05	861	176	15	36931259
Pubmed	Identification of Novel Nuclear Factor of Activated T Cell (NFAT)-associated Proteins in T Cells.	RNGTT BTAF1 AIFM1 SUPT6H RPTOR CABIN1 WDR48	3.64e-05	178	176	7	27637333
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	ANK3 SPOPL SCAMP1 DOCK9 SPTBN1 RICTOR SHROOM2 TRIP12 DCAF5 CLMN AGA ASXL2 PEAK1 PLEKHA7 QSOX2 PML RAD17	3.96e-05	1084	176	17	11544199
Pubmed	A methylation-phosphorylation switch controls EZH2 stability and hematopoiesis.	SPTBN1 DCAF5 SETD7 MMP9	4.09e-05	38	176	4	38346162
Pubmed	An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.	TANC2 IFT27 GALC RNGTT ANK3 ESYT1 ATG2B NEDD1 POM121C HDAC7 POM121 RPTOR GYS1 NUFIP2 PLEKHA7 IQGAP3 TRAPPC9 FOXJ1 WDR48	4.42e-05	1321	176	19	27173435
Pubmed	A non-proteolytic role for ubiquitin in deadenylation of MHC-I mRNA by the RNA-binding E3-ligase MEX-3C.	NOL6 AIFM1 NUFIP2 NXF1	7.35e-05	44	176	4	26471122
Pubmed	Ankyrin-G is a molecular partner of E-cadherin in epithelial cells and early embryos.	ANK3 SPTBN1	7.61e-05	3	176	2	17620337
Pubmed	Distribution and association of mTOR with its cofactors, raptor and rictor, in cumulus cells and oocytes during meiotic maturation in mice.	RICTOR RPTOR	7.61e-05	3	176	2	23440873
Pubmed	mTOR kinase inhibitors promote antibody class switching via mTORC2 inhibition.	RICTOR RPTOR	7.61e-05	3	176	2	25385646
Pubmed	mTOR has a developmental stage-specific role in mitochondrial fitness independent of conventional mTORC1 and mTORC2 and the kinase activity.	RICTOR RPTOR	7.61e-05	3	176	2	28813526
Pubmed	POM121 inhibits the macrophage inflammatory response by impacting NF-κB P65 nuclear accumulation.	POM121C POM121	7.61e-05	3	176	2	30802453
Pubmed	Matrix metalloproteinase-2 matrix metalloproteinase-9 and inducible nitric oxide synthase in oral leukoplakia: immunohistochemistry and RT-PCR analysis.	MMP9 NOS2	7.61e-05	3	176	2	18597705
Pubmed	Dendritic cell Piezo1 directs the differentiation of TH1 and Treg cells in cancer.	PIEZO1 SIRT1	7.61e-05	3	176	2	35993548
Pubmed	The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2.	RICTOR RHEB	7.61e-05	3	176	2	21358638
Pubmed	Signal-dependent regulation of transcription by histone deacetylase 7 involves recruitment to promyelocytic leukemia protein nuclear bodies.	HDAC7 PML	7.61e-05	3	176	2	18463162
Pubmed	Muscle inactivation of mTOR causes metabolic and dystrophin defects leading to severe myopathy.	RICTOR RPTOR	7.61e-05	3	176	2	20008564
Pubmed	Loss of SPTBN1 Suppresses Autophagy Via SETD7-mediated YAP Methylation in Hepatocellular Carcinoma Initiation and Development.	SPTBN1 SETD7	7.61e-05	3	176	2	34737104
Pubmed	Nucleoporin POM121 signals TFEB-mediated autophagy via activation of SIGMAR1/sigma-1 receptor chaperone by pridopidine.	POM121C POM121	7.61e-05	3	176	2	35507432
Pubmed	Set7/9 impacts COL2A1 expression through binding and repression of SirT1 histone deacetylation.	SIRT1 SETD7	7.61e-05	3	176	2	23873758
Pubmed	Impact of Raptor and Rictor Deletion on Hippocampal Pathology Following Status Epilepticus.	RICTOR RPTOR	7.61e-05	3	176	2	35618880
Pubmed	Human SIR2 deacetylates p53 and antagonizes PML/p53-induced cellular senescence.	SIRT1 PML	7.61e-05	3	176	2	12006491
Pubmed	T cell exit from quiescence and differentiation into Th2 cells depend on Raptor-mTORC1-mediated metabolic reprogramming.	RICTOR RPTOR	7.61e-05	3	176	2	24315998
Pubmed	Regulation of Rad17 protein turnover unveils an impact of Rad17-APC cascade in breast carcinogenesis and treatment.	FZR1 RAD17	7.61e-05	3	176	2	23637229
Pubmed	mTORC1 and mTORC2 selectively regulate CD8⁺ T cell differentiation.	RICTOR RHEB	7.61e-05	3	176	2	25893604
Pubmed	MicroRNA106a regulates matrix metalloprotease 9 in a sirtuin-1 dependent mechanism.	SIRT1 MMP9	7.61e-05	3	176	2	28233301
Pubmed	Expression Pattern of iNOS, BCL-2 and MMP-9 in the Hip Synovium Tissue of Patients with Osteoarthritis.	MMP9 NOS2	7.61e-05	3	176	2	33540799
Pubmed	mTOR phosphorylated at S2448 binds to raptor and rictor.	RICTOR RPTOR	7.61e-05	3	176	2	19145465
Pubmed	Overexpression of Kinase-Dead mTOR Impairs Glucose Homeostasis by Regulating Insulin Secretion and Not β-Cell Mass.	RICTOR RPTOR	7.61e-05	3	176	2	28546423
Pubmed	Raptor and Rheb negatively regulate skeletal myogenesis through suppression of insulin receptor substrate 1 (IRS1).	RHEB RPTOR	7.61e-05	3	176	2	21852229
Pubmed	mTORC1 and mTORC2 differentially promote natural killer cell development.	RICTOR RPTOR	7.61e-05	3	176	2	29809146
Pubmed	Expression and localization of Werner syndrome protein is modulated by SIRT1 and PML.	SIRT1 PML	7.61e-05	3	176	2	17996922
Pubmed	Evidence supporting the role of telomerase, MMP-9, and SIRT1 in attention-deficit/hyperactivity disorder (ADHD).	SIRT1 MMP9	7.61e-05	3	176	2	32691156
Pubmed	Autophagy-related genes Raptor, Rictor, and Beclin1 expression and relationship with multidrug resistance in colorectal carcinoma.	RICTOR RPTOR	7.61e-05	3	176	2	26363527
Pubmed	Histone deacetylase 7 promotes PML sumoylation and is essential for PML nuclear body formation.	HDAC7 PML	7.61e-05	3	176	2	18625722
Pubmed	Cancer cell survival following DNA damage-mediated premature senescence is regulated by mammalian target of rapamycin (mTOR)-dependent Inhibition of sirtuin 1.	SIRT1 RPTOR	7.61e-05	3	176	2	21471201
Pubmed	The Potential Role of BRCA1-Associated ATM Activator-1 (BRAT1) in Regulation of mTOR.	RPTOR BRAT1	7.61e-05	3	176	2	25657994
Pubmed	Expression of the mTOR pathway regulators in human pituitary adenomas indicates the clinical course.	RICTOR RPTOR	7.61e-05	3	176	2	23898069
Pubmed	Resveratrol inhibition of inducible nitric oxide synthase in skeletal muscle involves AMPK but not SIRT1.	SIRT1 NOS2	7.61e-05	3	176	2	21810931
Pubmed	Localization of Rheb to the endomembrane is critical for its signaling function.	RHEB RPTOR	7.61e-05	3	176	2	16631613
Pubmed	Myopathy caused by mammalian target of rapamycin complex 1 (mTORC1) inactivation is not reversed by restoring mitochondrial function.	RICTOR RPTOR	7.61e-05	3	176	2	22143799
Pubmed	Involvement of mTORC1 and mTORC2 in regulation of glioblastoma multiforme growth and motility.	RICTOR RPTOR	7.61e-05	3	176	2	19724909
Pubmed	Cytoplasmic and nuclear distribution of the protein complexes mTORC1 and mTORC2: rapamycin triggers dephosphorylation and delocalization of the mTORC2 components rictor and sin1.	RICTOR RPTOR	7.61e-05	3	176	2	18614546
Pubmed	Deacetylation of the tumor suppressor protein PML regulates hydrogen peroxide-induced cell death.	SIRT1 PML	7.61e-05	3	176	2	25032863
Pubmed	Skeletal muscle-specific ablation of raptor, but not of rictor, causes metabolic changes and results in muscle dystrophy.	RICTOR RPTOR	7.61e-05	3	176	2	19046572
Pubmed	Methyltransferase Set7/9 regulates p53 activity by interacting with Sirtuin 1 (SIRT1).	SIRT1 SETD7	7.61e-05	3	176	2	21245319
Pubmed	Leptin Signaling Suppression in Macrophages Improves Immunometabolic Outcomes in Obesity.	RICTOR RPTOR	7.61e-05	3	176	2	35377454
Pubmed	Conditional ablation of raptor or rictor has differential impact on oligodendrocyte differentiation and CNS myelination.	RICTOR RPTOR	7.61e-05	3	176	2	24671993
Pubmed	Lipolysis and the integrated physiology of lipid energy metabolism.	AIFM1 PLIN1	7.61e-05	3	176	2	18762440
Pubmed	Langerhans cell homeostasis in mice is dependent on mTORC1 but not mTORC2 function.	RICTOR RPTOR	7.61e-05	3	176	2	23212520
Pubmed	mTORC1 maintains renal tubular homeostasis and is essential in response to ischemic stress.	RICTOR RPTOR	7.61e-05	3	176	2	24958889
Interaction	TOP3B interactions	TANC2 EPPK1 ESYT1 POLE PIEZO1 RNPEPL1 DOCK9 SPTBN2 NAGLU MYOM3 BTAF1 WRAP53 NEDD1 POM121C HDAC7 C2CD2 ST14 KIAA2013 FZR1 MDN1 PROM2 RPTOR CHD5 NUFIP2 NLRC5 SECISBP2 PLA2G6 CABIN1 BRAT1 MMP17 IQGAP3 TRAPPC9	9.15e-07	1470	173	32	int:TOP3B
GeneFamily	WD repeat domain containing	NBEAL1 EML6 PEX7 WRAP53 NEDD1 DCAF5 RFWD3 FZR1 RPTOR TBL1X WDR48	3.59e-07	262	105	11	362
GeneFamily	EF-hand domain containing\|Spectrins	SPTBN1 SPTBN2 SPTBN5	6.55e-06	7	105	3	1113
GeneFamily	Components of oligomeric golgi complex	COG7 COG1	9.14e-04	8	105	2	493
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	ARHGAP23 DOCK9 SPTBN1 SPTBN2 OSBP2 PLEKHA7	1.28e-03	206	105	6	682
ToppCell	Parenchymal-NucSeq\|Parenchymal / Cell types per location group and 10X technology with lineage, and cell group designations	TANC2 ANK3 FBXL17 ADGRV1 PRICKLE2 SPIDR PEAK1 PLEKHA7 TRAPPC9	9.47e-08	198	175	9	1996373bdccc55aac347d349bd22f6aad6d0c668
ToppCell	390C-Fibroblasts-Fibroblast-B_(Myofibroblast)-\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	ACTRT3 ST14 NOTUM MMRN2 PLA2G6 KCNK17 IL27RA	3.38e-06	160	175	7	636127753e3a22831f39d4c8170df40901e4329d
ToppCell	390C-Fibroblasts-Fibroblast-B_(Myofibroblast)\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	ACTRT3 ST14 NOTUM MMRN2 PLA2G6 KCNK17 IL27RA	3.38e-06	160	175	7	cb8d0dc1a6c69c7a85c5fdd8f0f6cca1b73dfc63
ToppCell	mild-immature_Neutrophil\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	TANC2 AMDHD2 FZR1 GYS1 MMP9 QSOX2	4.62e-06	109	175	6	2f03d6ee8b13424cc6a5bc60ac3461b44dff9d79
ToppCell	PND03-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT2-AT2_prolif\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	AMDHD2 MYOM3 PEX7 ST14 HERC3 IQGAP3 QSOX2	4.66e-06	168	175	7	08f6e171a1ea5cf65149744296d0fcd6c7b9684e
ToppCell	356C-Lymphocytic-ILC-ILC-2\|ILC / Donor, Lineage, Cell class and subclass (all cells)	ATG2B KIAA2013 RFWD3 SPTBN5 RPTOR GYS1 TRAPPC9	5.44e-06	172	175	7	4977e1f4deae781750e27a8054deccd336cfb74a
ToppCell	10x5'v1-week_12-13-Myeloid_neutrophil-granulo-neutrophil-myelocyte\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	EPPK1 BTNL8 POLE IRAK2 GYS1 PEAK1 PRDX5	7.87e-06	182	175	7	52eac2f892ea7f26731e0b21c578fd2665a1657a
ToppCell	saliva-Mild-Moderate_progression_d12-25-Epithelial-Epithelial,_Airway-secretory_cell\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	TANC2 PIEZO1 RNPEPL1 HDAC7 ST14 TRMT44 PLEKHA7	9.39e-06	187	175	7	6e5c38425b6b1d4774f8dcea7e146f1eab785c3e
ToppCell	saliva-Mild-Moderate_progression_d12-25-Epithelial-Epithelial,_Airway-secretory_cell-Epi-Secretory\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	TANC2 PIEZO1 RNPEPL1 HDAC7 ST14 TRMT44 PLEKHA7	9.39e-06	187	175	7	43ef900b76f3c38bd8ce9858201124130c743d56
ToppCell	Control-Endothelial-VE_Capillary_A\|Endothelial / Disease state, Lineage and Cell class	SPTBN1 ITGA10 FRY SPON2 PRICKLE2 HERC3 NOS2	9.73e-06	188	175	7	88b3415e33db81726dd29c1f50c886e057af50a0
ToppCell	human_hepatoblastoma-Tumor_cells-T5\|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)	ANK3 HDAC7 NKD1 UBR5 PRICKLE2 B4GALNT3 TBL1X	9.73e-06	188	175	7	b070a0667f1ee9b825b267b6c389b7c42fc436f9
ToppCell	18-Airway-Mesenchymal-Airway_Smooth_Muscle\|Airway / Age, Tissue, Lineage and Cell class	RPS8 TRIP10 NKD1 NOTUM RPTOR PHACTR3 KCNK17	1.08e-05	191	175	7	86ce98d2c90c196474b06869de888cf5d1eed196
ToppCell	droplet-Mammary_Gland-nan-21m-Epithelial-luminal_epithelial_cell_of_mammary_gland\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TANC2 ANK3 SPTBN2 RIPK4 GPRC5A ST14 CLMN	1.15e-05	193	175	7	22ebc3f586eb0aabc5785e468c88d7416c624ff4
ToppCell	moderate-Epithelial-FOXN4+\|moderate / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	ISYNA1 COG7 SPTBN1 DNAH7 CEP78 CLMN FOXJ1	1.19e-05	194	175	7	5dffa578149104dda33774361e9e77b227b5f1ce
ToppCell	COVID-19-lung-Capillary_Aerocytes\|COVID-19 / Disease (COVID-19 only), tissue and cell type	BTNL8 DOCK9 SPTBN1 ITGA10 SHROOM2 PRICKLE2 HERC3	1.27e-05	196	175	7	49cc0a2b9739abad61dff7292ea0b14d28ff35c4
ToppCell	Control-Control-Lymphocyte-T/NK-CD4+_T_activated\|Control / Disease, condition lineage and cell class	MBLAC2 EPPK1 DOCK9 SPTBN1 ADCK2 NLRC5 PLEKHA7	1.36e-05	198	175	7	ee71543559836fd59adc0da877b2ca538cba60cb
ToppCell	Smart-start-Cell-Wel_seq-Neoplastic-Differentiated-like-MES-like-MES-like_hypoxia_independent-F\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	NBEAL1 PIEZO1 GPRC5A POM121C LOXHD1 POM121 GYS1	1.41e-05	199	175	7	85bb28369e0568b7b3bda095722102fc793f60ef
ToppCell	MS-CD8-proli_CD4\|MS / Condition, Cell_class and T cell subcluster	ATG2B SIRT1 GYS1 CC2D2A CABIN1 WDR48	6.14e-05	172	175	6	0b6dd257110b3f17fa71ab18a165b091a9d5ae9a
ToppCell	3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.0.5\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	TANC2 SMG1 ANK3 ADGRV1 GPRC5A B4GALNT3	7.65e-05	179	175	6	6e965e424eebef50f0202cff75f458be395cfca1
ToppCell	COVID-19_Convalescent-Classical_Monocyte-cMono_4\|Classical_Monocyte / Disease condition and Cell class	APOL1 OGG1 FZR1 MDN1 PIM1 TRAPPC9	7.65e-05	179	175	6	9d51318ac198a8801bd5c7031ebf2b0c74ffeeb6
ToppCell	COVID-19_Convalescent-Classical_Monocyte-cMono_4\|COVID-19_Convalescent / Disease condition and Cell class	APOL1 OGG1 FZR1 MDN1 PIM1 TRAPPC9	7.65e-05	179	175	6	366e4a31db9e80fd1770ac9f1ae148fefeb9f7df
ToppCell	3'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.3.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	EPPK1 GPR162 DNAH7 CLMN KNDC1 FOXJ1	7.89e-05	180	175	6	92fb01b91261b3103454924cde56add337b41844
ToppCell	COVID-19-Endothelial_cells-Capillary_endothelial_cells\|COVID-19 / group, cell type (main and fine annotations)	DOCK9 SPTBN1 SHROOM2 PRICKLE2 HERC3 NOS2	8.13e-05	181	175	6	c5f9c92af1384d9089c65afdf41c6feb8345a3ae
ToppCell	COVID-19-Epithelial_cells-Airway_club\|COVID-19 / group, cell type (main and fine annotations)	ANK3 DOCK9 ADGRV1 GPRC5A B4GALNT3 PLEKHA7	9.17e-05	185	175	6	cfe6fd73d817e173fe803bc1683c291d9bcb8608
ToppCell	368C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_0\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	WRAP53 NEDD1 CEP78 AGA SPOP RAD17	9.17e-05	185	175	6	7925519b855f76444a0b57382ce35d89457b0b14
ToppCell	TCGA-Pancreas-Primary_Tumor-Pancreatic_Adenocarcinoma-Ductal_Adenocarcinoma-1\|TCGA-Pancreas / Sample_Type by Project: Shred V9	SMG1 SPOPL NBEAL1 HEATR5A NKD1 ASXL2	9.45e-05	186	175	6	03db813598b67b1e08f759758a1c2023396921fa
ToppCell	390C-Lymphocytic-CD4_T-cell-Treg_cell_3\|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)	IRAK2 FBXO36 CCDC112 P2RX5 MMP9 QSOX2	9.73e-05	187	175	6	1eed2c1a05e80a7c8f639437c117afe0c18dfb0c
ToppCell	343B-Endothelial_cells-Endothelial-C_(Capillary_Aerocyte_)-\|343B / Donor, Lineage, Cell class and subclass (all cells)	DOCK9 SPTBN1 ITGA10 FRY PRICKLE2 NOS2	1.00e-04	188	175	6	fe7143c36e4a883745862d3c3147cf751b440e46
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Cortical_Collecting_Duct_Principal_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	TANC2 ANK3 SPTBN2 EML6 GPRC5A FRY	1.00e-04	188	175	6	e30a4ddac0da8cdcf621d98e28e3895cd9307e7a
ToppCell	343B-Endothelial_cells-Endothelial-C_(Capillary_Aerocyte_)\|343B / Donor, Lineage, Cell class and subclass (all cells)	DOCK9 SPTBN1 ITGA10 FRY PRICKLE2 NOS2	1.00e-04	188	175	6	cbf32b675a7cd0c808d5c9c22dfa7fa79fbe2437
ToppCell	nucseq-Endothelial-Endothelial_Vascular-Endothelial_capillary-CAP2\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	DOCK9 SPTBN1 ITGA10 SHROOM2 FRY PRICKLE2	1.03e-04	189	175	6	b6b4da51bc7f2c13a2f940540fdc61027d084835
ToppCell	IPF-Endothelial-VE_Capillary_A\|World / Disease state, Lineage and Cell class	DOCK9 SPTBN1 ITGA10 SHROOM2 PRICKLE2 NOS2	1.03e-04	189	175	6	ea3aa3ef38f1d405bb527ae383cd12c551a3dd6f
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ANK3 PIEZO1 SPTBN2 EML6 GPRC5A FRY	1.03e-04	189	175	6	fc88c51ace7d883c01617f3f9b5fab70cc91cc09
ToppCell	COVID-19-lung-Secretory\|lung / Disease (COVID-19 only), tissue and cell type	ANK3 ADGRV1 GPRC5A PROM2 B4GALNT3 PLEKHA7	1.03e-04	189	175	6	84d48e3ed25bebb8bb8074b3a2c5e2e88cff7f25
ToppCell	PCW_07-8.5-Epithelial-Epithelial_airway-epi_intermediate_(1)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	RIPK4 ADGRV1 ST14 FRY ACSM3 FOXJ1	1.06e-04	190	175	6	c95032bb3ee2b3d40fdf48016acb46d6f78a48a6
ToppCell	IPF-Endothelial-VE_Capillary_A\|IPF / Disease state, Lineage and Cell class	DOCK9 SPTBN1 ITGA10 SHROOM2 PRICKLE2 NOS2	1.06e-04	190	175	6	b4e35cbfe4d43d2cd51f29c3085e4d9b1012e6f0
ToppCell	Children_(3_yrs)-Endothelial-alveolar_capillary_endothelial_cell_(Cap2;_aerocyte)-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	BTNL8 DOCK9 SPTBN1 ITGA10 SHROOM2 PRICKLE2	1.06e-04	190	175	6	0a351609a72fd638c84b2435782e312ee6a33aac
ToppCell	droplet-Liver-hepatocytes-3m-Epithelial-duct_epithelial_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ANK3 FBXO36 ST14 TTC19 TMTC4 PROM2	1.06e-04	190	175	6	5b3f773380aef4773b70f0dbd74992d28e6586c6
ToppCell	droplet-Mammary_Gland-nan-21m-Epithelial-luminal_epithelial_cell_of_mammary_gland\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TANC2 ANK3 RIPK4 ST14 NOTUM PROM2	1.09e-04	191	175	6	b94e66ac71e73f46b0323d424e7b8b906751d584
ToppCell	facs-Lung-EPCAM-3m-Epithelial\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EPPK1 ANK3 RBPJL GPRC5A ST14 CLMN	1.09e-04	191	175	6	629007189034ee8451411428f1c6cc57daee2d91
ToppCell	Adult-Epithelial\|Adult / Lineage, Cell type, age group and donor	ANK3 DOCK9 ADGRV1 GPRC5A B4GALNT3 PLEKHA7	1.12e-04	192	175	6	efb962a5fd3b9bdfd8cf8d13c435e29c8271713e
ToppCell	IPF-Epithelial-Basal\|World / Disease state, Lineage and Cell class	ANK3 ARHGAP23 RIPK4 GPRC5A PROM2 B4GALNT3	1.12e-04	192	175	6	9b91e0b162e6f3ce86dd15cc33c2e745d069581f
ToppCell	nucseq-Endothelial-Endothelial_Vascular-Endothelial_capillary\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	BTNL8 DOCK9 SPTBN1 ITGA10 SHROOM2 PRICKLE2	1.16e-04	193	175	6	f582e939e3e08a8a3f71deec78c33715be8faa51
ToppCell	TCGA-Prostate-Primary_Tumor-Prostate_Adenocarcinoma-Acinar_Adenocarcinoma-6\|TCGA-Prostate / Sample_Type by Project: Shred V9	SPOPL NBEAL1 HEATR5A ADGRV1 LRRC58 ASXL2	1.16e-04	193	175	6	abd71b2cf667ef2b1c4d88acd0c1dd19a12ff659
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	TANC2 GPRC5A DNAH7 CLMN PHACTR3 PLEKHA7	1.16e-04	193	175	6	f42a0f02ed00fe1bb833ff0a0640d9131bca89bd
ToppCell	COVID-19-kidney-CD-PC\|kidney / Disease (COVID-19 only), tissue and cell type	TANC2 ANK3 SPTBN2 EML6 GPRC5A FRY	1.16e-04	193	175	6	738689d009e4b118d7ce3171a207294b95cbe78b
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	TANC2 GPRC5A DNAH7 CLMN PHACTR3 PLEKHA7	1.16e-04	193	175	6	42df7ed37d11fb542b4d1d714b6f87ae8e1396a6
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ANK3 PIEZO1 SPTBN1 SPTBN2 EML6 GPRC5A	1.19e-04	194	175	6	4579b4a44f7c731553a284843c296866027d7c0e
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	TANC2 GPRC5A DNAH7 CLMN PHACTR3 PLEKHA7	1.19e-04	194	175	6	e577d9e88390b36b5a09b97fe1026089892275a3
ToppCell	normal_Lung-Epithelial_cells-Ciliated\|Epithelial_cells / Location, Cell class and cell subclass	IFT27 GPR162 DNAH7 RABL2B PRDX5 FOXJ1	1.22e-04	195	175	6	a3e2999fdd4c3575add6e28ecfd1d6606a61f992
ToppCell	Children_(3_yrs)-Epithelial-club_cell-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	ANK3 ADGRV1 GPRC5A PROM2 PRICKLE2 B4GALNT3	1.22e-04	195	175	6	dccc32fcf772e2504de7f663ef0a5bd8e23e92fc
ToppCell	moderate-Epithelial-Ciliated\|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	GPR162 DNAH7 RABL2B CLMN CC2D2A FOXJ1	1.22e-04	195	175	6	3486eae5fdb062a75a907b896c9d7b396d2aa195
ToppCell	moderate-Epithelial-Ciliated\|moderate / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	GPR162 DNAH7 RABL2B CLMN CC2D2A FOXJ1	1.22e-04	195	175	6	e80f5cdf0b18066b3e6c2f5452e58f101c67932c
ToppCell	Bronchial-NucSeq\|Bronchial / Cell types per location group and 10X technology with lineage, and cell group designations	TANC2 ANK3 FBXL17 ADGRV1 SPIDR TRAPPC9	1.26e-04	196	175	6	ab53c742866945545a92e2e61850d63c80d9a2a6
ToppCell	COPD-Multiplet-Multiplet\|COPD / Disease state, Lineage and Cell class	ANK3 SPTBN1 GPRC5A DNAH7 PRICKLE2 FOXJ1	1.26e-04	196	175	6	af4cdc61830685a888a1209826c23bcf54a43084
ToppCell	COPD-Multiplet\|COPD / Disease state, Lineage and Cell class	ANK3 SPTBN1 GPRC5A DNAH7 PRICKLE2 FOXJ1	1.26e-04	196	175	6	6d02d494196e3f857d53eea46d9419690d43beca
ToppCell	COVID-19-lung-Capillary_Aerocytes\|lung / Disease (COVID-19 only), tissue and cell type	DOCK9 SPTBN1 SHROOM2 FRY PRICKLE2 HERC3	1.26e-04	196	175	6	4ac4073380d939a73cec7413e9f3f5ef616d2924
ToppCell	facs-Tongue-nan-3m-Epithelial\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SMG1 EPPK1 SPTBN1 RIPK4 LRRC58 NUFIP2	1.33e-04	198	175	6	2f03f8897dd7cce6d8296638e14e11ec16bcf624
ToppCell	facs-Tongue-nan-3m\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SMG1 EPPK1 SPTBN1 RIPK4 LRRC58 NUFIP2	1.33e-04	198	175	6	f2a4057f038ef7225a5b98a7ab068c30dff4eadd
ToppCell	(6)_Endothelial-E\|World / Lung cell shreds - cell class (v4) and cell subclass (v4)	BTNL8 DOCK9 SPTBN1 ITGA10 FRY MMRN2	1.33e-04	198	175	6	a5e1b321376caf262ea48904d31afd1b8e9d3be2
ToppCell	mild-low-quality_cells\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	SMG1 ANK3 RICTOR BTAF1 CEP78 NLRC5	1.37e-04	199	175	6	f0b0097df0026496470a80d8cc9375ffd8389b00
ToppCell	Bronchial-10x5prime-Endothelial-Endothelia_vascular-VE_alveolar_capillary_Car4_aerocyte\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	DOCK9 SPTBN1 ITGA10 FRY PRICKLE2 NOS2	1.37e-04	199	175	6	7ed541309808f15d65a9c4b26be2050e077539e6
ToppCell	Parenchymal-NucSeq-Endothelial-Endothelia_vascular-VE_alveolar_capillary_Car4_aerocyte\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	ITGA10 IRAK2 FRY SPON2 PRICKLE2 NOS2	1.37e-04	199	175	6	dc88ce36cc066eb6c28cfd5b9b60fe07f8cc7b53
ToppCell	distal-Endothelial-Capillary_Aerocyte-2\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	DOCK9 SPTBN1 ITGA10 IRAK2 FRY NOS2	1.37e-04	199	175	6	9021f4be004efd51bb3658e5bbff53589356b3df
ToppCell	(09)_Interm._secr.>cil.\|World / shred by cell type by condition	DNAH7 DNAAF8 RABL2B CLMN CC2D2A FOXJ1	1.40e-04	200	175	6	3305e14dba12e94da42f0414fdc7a2c8caf0a183
ToppCell	Sigmoid-Dendritic_cell-cDC1\|Dendritic_cell / Region, Cell class and subclass	ANK3 ACTRT3 ATG2B IRAK2 C2CD2 TMTC4	1.40e-04	200	175	6	09deb831fc2c8a8867cc850f3aa094a5e48489ff
ToppCell	10x_3'_v2v3-Non-neoplastic-Endothelial-Endothelial_mature-Endo_capilar\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	BTNL8 DOCK9 SPTBN1 ITGA10 FRY MMRN2	1.40e-04	200	175	6	c239e6f5d23caa9a59b83e9b352b2d6a691dcb28
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW26\|organoid_Tanaka_cellReport / Sample Type, Dataset, Time_group, and Cell type.	ARHGAP23 DOCK9 ITGA10 CHD5 KNDC1 MMP17	1.40e-04	200	175	6	5c7263c862093ad9dbc81d06b16b6f74e8a6b634
ToppCell	3'-Parenchyma_lung-Endothelial-Blood_vessel_EC-capillary_endothelial_cell-EC_aerocyte_capillary-EC_aerocyte_capillary_L.2.0.1.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	DOCK9 SPTBN1 ITGA10 IRAK2 FRY PML	1.40e-04	200	175	6	16a70cc07dcfb4eba4385b712f27010c6629ff67
ToppCell	PBMC-Control-Myeloid-Neutrophil-Neutrophil-Neu_0\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	BTNL8 EEF1AKMT3 MYOM3 MMP9 IQGAP3	1.51e-04	128	175	5	58639cfdc70ff6764adcc5c1ce9eba9d033b8209
ToppCell	PBMC-Control-Myeloid-Neutrophil-Neutrophil-Neu_0\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	BTNL8 EEF1AKMT3 MYOM3 MMP9 IQGAP3	1.51e-04	128	175	5	9b3c57d559a5ed8d590dd89b64a57a3227d8c684
Disease	carboxypeptidase Z measurement	GPR78 TRMT44	1.92e-04	4	168	2	EFO_0801455
Disease	spinocerebellar ataxia type 5 (implicated_via_orthology)	SPTBN1 SPTBN2	1.92e-04	4	168	2	DOID:0050882 (implicated_via_orthology)
Disease	epilepsy (is_marker_for)	SIRT1 MMP9	1.92e-04	4	168	2	DOID:1826 (is_marker_for)
Disease	hepatitis (biomarker_via_orthology)	OGG1 NOS2	1.92e-04	4	168	2	DOID:2237 (biomarker_via_orthology)
Disease	renal hypertension (implicated_via_orthology)	MMP9 NOS2	3.19e-04	5	168	2	DOID:1073 (implicated_via_orthology)
Disease	pleurisy (biomarker_via_orthology)	PLA2G6 NOS2	3.19e-04	5	168	2	DOID:10247 (biomarker_via_orthology)
Disease	pulmonary emphysema (biomarker_via_orthology)	MMP9 NOS2	4.76e-04	6	168	2	DOID:9675 (biomarker_via_orthology)
Disease	Retinal Diseases	SIRT1 MMP9 NOS2	4.80e-04	27	168	3	C0035309
Disease	Prostatic Neoplasms	FOLH1 NAGLU OGG1 ST14 SIRT1 ACSM3 SPON2 ALOXE3 SPOP MMP9 PML	8.48e-04	616	168	11	C0033578
Disease	Malignant neoplasm of prostate	FOLH1 NAGLU OGG1 ST14 SIRT1 ACSM3 SPON2 ALOXE3 SPOP MMP9 PML	8.48e-04	616	168	11	C0376358
Disease	Vasogenic Brain Edema	MMP9 NOS2	8.82e-04	8	168	2	C0750969
Disease	Cytotoxic Brain Edema	MMP9 NOS2	8.82e-04	8	168	2	C0750970
Disease	Cytotoxic Cerebral Edema	MMP9 NOS2	8.82e-04	8	168	2	C0472388
Disease	Vasogenic Cerebral Edema	MMP9 NOS2	8.82e-04	8	168	2	C0472387
Disease	head and neck squamous cell carcinoma (is_marker_for)	WRAP53 OGG1	8.82e-04	8	168	2	DOID:5520 (is_marker_for)
Disease	Brain Edema	MMP9 NOS2	8.82e-04	8	168	2	C1527311
Disease	Cerebral Edema	MMP9 NOS2	8.82e-04	8	168	2	C0006114
Disease	Marfan Syndrome, Type I	MMP9 NOS2	1.13e-03	9	168	2	C4721845
Disease	egg allergy measurement	COG7 ITIH6	1.13e-03	9	168	2	EFO_0007018
Disease	glomerulosclerosis (implicated_via_orthology)	MMP9 PLEKHA7	1.71e-03	11	168	2	DOID:0050851 (implicated_via_orthology)
Disease	Premature Birth	OGG1 MMP9	1.71e-03	11	168	2	C0151526
Disease	Marfan Syndrome	MMP9 NOS2	1.71e-03	11	168	2	C0024796
Disease	middle cerebral artery infarction (biomarker_via_orthology)	OGG1 AIFM1 MMP9 NOS2	2.00e-03	93	168	4	DOID:3525 (biomarker_via_orthology)
Disease	Huntington Disease, Late Onset	OGG1 AIFM1	2.05e-03	12	168	2	C0393574
Disease	triacylglycerol 58:12 measurement	FBXO36 TRIP12	2.05e-03	12	168	2	EFO_0010439
Disease	Akinetic-Rigid Variant of Huntington Disease	OGG1 AIFM1	2.05e-03	12	168	2	C0751207
Disease	Juvenile Huntington Disease	OGG1 AIFM1	2.05e-03	12	168	2	C0751208
Disease	lymphangioleiomyomatosis (is_marker_for)	RICTOR MMP9	2.05e-03	12	168	2	DOID:3319 (is_marker_for)
Disease	colorectal cancer (is_marker_for)	RICTOR WRAP53 HDAC7 SPOP MMP9	2.10e-03	157	168	5	DOID:9256 (is_marker_for)
Disease	lung disease (implicated_via_orthology)	MMP9 NOS2	2.41e-03	13	168	2	DOID:850 (implicated_via_orthology)
Disease	plasma beta-amyloid 1-42 measurement	ANK3 FBXL17	2.41e-03	13	168	2	EFO_0005660
Disease	survival time, breast carcinoma	KCNH7 TBL1X	2.41e-03	13	168	2	EFO_0000305, EFO_0000714
Disease	bronchiolitis obliterans (is_marker_for)	MMP9 NOS2	2.41e-03	13	168	2	DOID:2799 (is_marker_for)
Disease	epilepsy (implicated_via_orthology)	KCNH7 PRICKLE2 SLC13A5 KCNK17 NOS2	2.47e-03	163	168	5	DOID:1826 (implicated_via_orthology)
Disease	status epilepticus (biomarker_via_orthology)	ANK3 OGG1 MMP9 HRH3	2.60e-03	100	168	4	DOID:1824 (biomarker_via_orthology)
Disease	response to olanzapine	SPOPL ADGRV1	3.22e-03	15	168	2	GO_0097333
Disease	head and neck squamous cell carcinoma (is_implicated_in)	WRAP53 OGG1	3.22e-03	15	168	2	DOID:5520 (is_implicated_in)
Disease	Streptozotocin Diabetes	SIRT1 AIFM1 MMP9 NOS2	3.43e-03	108	168	4	C0038433
Disease	Diabetes Mellitus, Experimental	SIRT1 AIFM1 MMP9 NOS2	3.43e-03	108	168	4	C0011853
Disease	Alloxan Diabetes	SIRT1 AIFM1 MMP9 NOS2	3.43e-03	108	168	4	C0002152
Disease	Benign neoplasm of stomach	POLE UBR5	4.14e-03	17	168	2	C0153943
Disease	ocular hypertension (biomarker_via_orthology)	ACSM3 MMP9	4.14e-03	17	168	2	DOID:9282 (biomarker_via_orthology)
Disease	Neoplasm of uncertain or unknown behavior of stomach	POLE UBR5	4.14e-03	17	168	2	C0496905
Disease	Huntington Disease	OGG1 AIFM1	4.14e-03	17	168	2	C0020179
Disease	Carcinoma in situ of stomach	POLE UBR5	4.14e-03	17	168	2	C0154060
Disease	nevus count	GPRC5A PLA2G6	4.64e-03	18	168	2	EFO_0004632
Disease	Gastric ulcer	MMP9 NOS2	4.64e-03	18	168	2	C0038358
Disease	Malignant neoplasm of endometrium	POLE SPOP	4.64e-03	18	168	2	C0007103
Disease	Carcinoma in situ of endometrium	POLE SPOP	4.64e-03	18	168	2	C0346191
Disease	creatinine measurement	IGF2-AS FBXL17 FBXO36 BTAF1 ADGRV1 ST14 RFWD3 FRY ACSM3 PLA2G6 ASXL2 PLEKHA7 QSOX2	4.70e-03	995	168	13	EFO_0004518
Disease	psoriasis vulgaris	KCNH7 PRDX5 NOS2	5.12e-03	61	168	3	EFO_1001494
Disease	cutaneous melanoma	ADGRV1 GPRC5A FZR1 PLA2G6	5.14e-03	121	168	4	EFO_0000389
Disease	Abnormality of refraction	SMG1 ANK3 GPR78 FRY ARL6IP6 PHACTR3 PLA2G6 PEAK1 QSOX2 TBL1X	5.37e-03	673	168	10	HP_0000539
Disease	amino acid measurement	TANC2 FOLH1 COG7 TMEM114 GPR162 DNAH7 MLYCD SETD7 HRH3 IL27RA	5.65e-03	678	168	10	EFO_0005134

Protein segments in the cluster

Peptide	Gene	Start	Entry
ALSLHDWIASQFSGR	ERVPABLB-1	431	P60509
ADQLCLDRWFTLSSG	ESYT1	886	Q9BSJ8
AASRDLDWEVRAQGL	BRAT1	641	Q6PJG6
LRQAFGDDWGSILSF	ADCK2	186	Q7Z695
FDVKEWINAAFRAGS	COG7	11	P83436
WINAAFRAGSKEAAS	COG7	16	P83436
DTWALGNSETEKAFR	CCDC112	116	Q8NEF3
LRFSWAQGTDTILAD	CHD5	711	Q8TDI0
NAEFWLSLDDQVSGL	B4GALNT3	191	Q6L9W6
VDRDIQLLCQSSGWF	BTNL8	146	Q6UX41
LCVGDQAQDWRSSLF	ACTRT3	51	Q9BYD9
ELQARSNIWVAGDAA	AIFM1	426	O95831
AEAARQASASRAWGL	FDXR	291	P22570
SDADSQAIWGLADQL	ADGRV1	5621	Q8WXG9
AASEPRALDWVASAN	AJM1	956	C9J069
FGSRLGVAARVWDAA	EEF1AKMT3	46	Q96AZ1
CAFADSLSEDLWLRA	CEP78	246	Q5JTW2
RFILLEGSQLDASDW	ASTN1	426	O14525
LQLSGVSLFWDEFSA	ATG2B	221	Q96BY7
FFTSAAQGWKERLSE	ASXL2	331	Q76L83
ASDSRFLLGSWLEQA	NAGLU	611	P54802
FLLGSWLEQARAAAV	NAGLU	616	P54802
LAASADLRGGFDWSL	GALNT16	251	Q8N428
DSFAVSAAWARKGIE	NKD1	21	Q969G9
DDTWIERGQVFSALS	NBEAL1	1461	Q6ZS30
DDTILSSALAANGWV	GPRC5A	241	Q8NFJ5
LSVEDGAFVASARQW	RBPJL	231	Q9UBG7
GAFVASARQWAAFTL	RBPJL	236	Q9UBG7
SARQWAAFTLHLADG	RBPJL	241	Q9UBG7
FADILSGDWNTRSLL	RAD17	476	O75943
GDVRDWASAIRVAAL	QSOX2	106	Q6ZRP7
EAANSALLWDAASGS	RFWD3	721	Q6PCD5
VFDGWDISSLNLAEA	ISYNA1	136	Q9NPH2
IDAASPFWEASRRAL	KCNJ9	251	Q92806
DGRTILVDFWDTAGQ	RABL2B	66	Q9UNT1
ELSGQEDAFRSWAVQ	NOS2	661	P35228
VIDDAFARAFALWSA	MMP9	136	P14780
DASANEILGSLRWRD	MDN1	2711	Q9NU22
FIGDAATANNRFELW	DUSP13	46	Q6B8I1
FADVLSRLALWESEG	MAGEC3	311	Q8TD91
RFASSGDDIKIWDAS	NEDD1	6	Q8NHV4
DWSIEAAVATFAQAR	RNGTT	146	O60942
LAGDSLFWSEADVVQ	IRAK2	191	O43187
AGAEEASLRSNALSW	GPR162	6	Q16538
ALQRAAWGISETESD	KCNH7	1011	Q9NS40
QALGWDELAARVTAL	MMRN2	651	Q9H8L6
SLALSDRGQLFSWGA	HERC3	96	Q15034
WTGEIFAQAFLGRES	ALOXE3	546	Q9BYJ1
TDWIGFAVAQRLAQD	DHRS4L1	41	P0CG22
FGLLGSTEWAEENSR	FOLH1	426	Q04609
GNRAGWFLDRIDITD	LOXHD1	891	Q8IVV2
LSEWFSSGFLNLERV	MLYCD	186	O95822
NGALTEALARWEAAA	CCDC194	136	A0A1B0GVG4
LSQALREAEADGAAW	PDCD7	191	Q8N8D1
WTLEGRAAQDSSRSF	KCNK17	41	Q96T54
WLDGNSLCDTFRDQS	NXF1	321	Q9UBU9
QLRFGVDSWSDFRLT	PEAK1	1316	Q9H792
FASASGDQTLRIWDV	PEX7	171	O00628
SGEIWARFLAFESNI	CSTF3	481	Q12996
ALAEDTGWRQLFFTN	FBXO36	151	Q8NEA4
WVRAQLLGEGFADES	NOL6	861	Q9H6R4
NIFASSSDDGRVLIW	DCAF5	156	Q96JK2
LASASSVWGFREELA	IL27RA	401	Q6UWB1
ADLSAETLQARREWG	L1RE1	251	Q9UN81
SSSLQDFDIRAILDW	POLE	1116	Q07864
AGWAQAVLFSADLRQ	OGG1	311	O15527
FLESAGWDLQIALAS	NSFL1C	26	Q9UNZ2
SVAALSADQWLAVGF	GPR78	96	Q96P69
QQEAWFALDLGLDSS	NUDT13	101	Q86X67
DWSSADNVLDGASLV	OSBP2	486	Q969R2
GRFQDSWRLSDGFVA	RICTOR	356	Q6R327
SWRLSDGFVAAEAKT	RICTOR	361	Q6R327
NRALEARDASGFWSS	IQGAP3	451	Q86VI3
VLAAGTDFRSDRLWE	PRPF39	196	Q86UA1
AAVVTAGEAELNWSR	LRRC58	6	Q96CX6
SWNLLGDEAAAELAQ	NLRC5	1776	Q86WI3
AAAALAWLAVGTTAA	POM121C	51	A8CG34
ELAWGVARDTAEFAA	PLIN1	151	O60240
ALAESWNAAFLESSA	RHEB	136	Q15382
AIQVRGLADSGWFLD	NOTUM	256	Q6P988
SRDAWQDLAGCDFVL	MYO15B	696	Q96JP2
LSVNDAFVTGEWGRA	PRDX5	126	P30044
TVSDLALQNAFGDRW	PRICKLE2	751	Q7Z3G6
AAAALAWLTVGATAA	POM121	51	Q96HA1
FSEAQAAAWLEAARG	FJX1	136	Q86VR8
ALAWNAEQLSSGSRD	FZR1	276	Q9UM11
RAVDSAEARAWALGQ	IFT27	131	Q9BW83
GSERSNALWQAVDAA	IGF2-AS	86	Q6U949
AESWARLAQVVDDGA	HEATR5A	871	Q86XA9
WSTSDQFLDLLAGDE	CC2D2A	1351	Q9P2K1
LSFASSQRDLFEDGW	CABIN1	596	Q9Y6J0
GEAQWLALVSLFVAA	C2CD2	11	Q9Y426
AWAARTLFKDASGNL	DOCK9	526	Q9BZ29
DAAWVSVANRGQFAS	COG1	486	Q8WTW3
LRSANWDTRIAAGQA	BTAF1	51	O14981
LFGRRWAIASDDLVF	DAGLB	6	Q8NCG7
LAAAAAWEQQGRSLF	FBXL17	146	Q9UF56
WSDGVLAVSFRAFAS	DNAH7	1666	Q8WXX0
GDKSRAWVAAAEESL	DNAAF8	76	Q8IYS4
TLASDLQDWASVGAF	FOXJ1	406	Q92949
LGLSWTELARELNFS	ANK3	4101	Q12955
LLLTDNEAWNGFVAA	APOL1	86	O14791
ARGFSAAWTAVLAAL	HRH3	26	Q9Y5N1
EALARGDNFETVTWL	MBLAC2	106	Q68D91
ADGWTDVNSALLAAA	ITIH6	356	Q6UXX5
TASLDEWTAGARAAF	ITGA10	701	O75578
FKNATEAAWRALASG	AGA	36	P20933
GARQLESAAAEQWVS	KNDC1	431	Q76NI1
LFISASNDGTARIWD	EML6	1701	Q6ZMW3
NSLQGLLVDFSDWRE	FRY	646	Q5TBA9
NAARWAAGSVTDLAF	HDAC7	636	Q8WUI4
REANDAVLFGFLTTW	GYS1	146	P13807
QLDSLWLLDSDGSFT	GALC	441	P54803
RALRLDVGNFSWGSE	RPS8	56	P62241
FLAVNTWGRAIFDLD	SLC13A5	541	Q86YT5
EFGWRNVFLLSAAVN	SLC17A4	456	Q9Y2C5
SRLSTGASADAVWDN	PRIMPOL	501	Q96LW4
SVIRWAGSDFQDIAL	P2RX5	236	Q93086
RALELFDWLGAVFSN	RPP40	236	O75818
EAWSFDGALENKRTA	PHACTR3	341	Q96KR7
RGALQEELARSFFWQ	PIM1	136	P11309
DNTANFLSWCRDLGV	GAS2	111	O43903
WNLGADAGSRLTDVF	MEIOC	36	A2RUB1
VGELWDRFQTRSFLA	SPATA48	291	A4D263
LSGAVEQWLSAAERL	RNPEPL1	291	Q9HAU8
WEDFSQSLARGNSEL	TRMT44	146	Q8IYL2
SNGLRDFAERGEAWA	SPON2	91	Q9BUD6
IWDAFTGELRASFRA	WRAP53	256	Q9BUR4
ERLLSNGWETASAVD	LCMT1	266	Q9UIC8
AEDLSLGVEWLSRFG	MMP17	46	Q9ULZ9
RLWEFQEAISGFLAA	PML	696	P29590
EQLVDLTSRDGAWFL	SMG1	2791	Q96Q15
FATWLLEAQAATGFL	EPPK1	1926	P58107
DLWRIEDVTAGLSAN	PLEKHA7	811	Q6IQ23
DSRDWALNGNTLSLD	SETD7	256	Q8WTS6
ASQRLAASITWADGE	SHROOM2	561	Q13796
AAAALWREAEAEAAA	SIRT1	71	Q96EB6
RFAGLNVAWLESSEA	SECISBP2	26	Q96T21
VDSARAVDFGLSILW	SCAMP1	176	O15126
VERAQINSFDSLWGE	TANC2	1021	Q9HCD6
SIGSQWARAEDALQA	SPATA31E1	1021	Q6ZUB1
SDQLVWRAARSSGAA	PLA2G6	626	O60733
AFWALTQLLAGERHS	TBC1D26	206	Q86UD7
DADARAVALAGSTNW	SPSB3	21	Q6PJ21
ASLSFAESWDNVGLL	NIF3L1	41	Q9GZT8
VDDAGLLSFATFSWL	ABCC12	46	Q96J65
LALLRTFDAGEFTGW	RIPK4	11	P57078
TATDDGAIRVWKNFA	RPTOR	1086	Q8N122
AGLEWAEAARSQALQ	SPTBN5	401	Q9NRC6
QFSRDASVAEAWLLG	SPTBN1	2021	Q01082
FWFVARADDVILSSG	ACSM3	471	Q53FZ2
VARDLRAEFSAGAWS	ARL6IP6	51	Q8N6S5
VAVQDFAGSWRSGLA	CLMN	206	Q96JQ2
AWLAEAESRVLSNRG	TRIP10	466	Q15642
LSIFLAWDVDIGSDN	C12orf71	86	A8MTZ7
AFSLGATLWINSEEF	SUPT6H	1391	Q7KZ85
FARIWTEDGNLASTL	TBL1X	311	O60907
SGEWRSEEQLFRSAL	TMTC4	461	Q5T4D3
AALAWFSRPAAAEEE	TTC19	61	Q6DKK2
LVASAGLDRQIFLWD	WDR48	131	Q8TAF3
GLERNDSWGSFDLRA	NUFIP2	646	Q7Z417
AEAWAQLQGSSAARR	SPTBN2	1886	O15020
LSWARTLELGADFSQ	PROM2	311	Q8N271
LRTAGAAASLSEAWL	SPIDR	36	Q14159
LAEDLGNLWENTRFT	SPOPL	186	Q6IQ16
LADELGGLWENSRFT	SPOP	186	O43791
LSDATFSDIRREGWL	ARHGAP23	681	Q9P227
WALRGDADSVLSLTF	ST14	246	Q9Y5Y6
DLRQFWVAEGGTISD	TERB2	16	Q8NHR7
ALATALDVGLSNWSF	SLC35C2	91	Q9NQQ7
ALLDQVDISFGWSLA	TMEM114	176	B3SHH9
LFAAGVWLARNLSDI	TOMM6	51	Q96B49
ELLRSVNDFLWLGAA	TRAPPC9	231	Q96Q05
RWSIGKAIDFAASLA	ZFAND1	186	Q8TCF1
VANRLASDGATWADI	PLBD2	351	Q8NHP8
ASDGATWADIFKRFN	PLBD2	356	Q8NHP8
WRNLTGFTDEQLGDL	PIEZO1	656	Q92508
GFFTLDSALLRTQWD	TRUB2	261	O95900
DCRISNNFTGLEWDL	TOR3A	116	Q9H497
IFWALNEGVSRQFDS	TRIP12	1826	Q14669
GVIDDAFALWLQDST	VIRMA	751	Q69YN4
RWLDGASFDNERGST	UBR5	321	O95071
GFLALDVAANRLWVT	KIAA2013	96	Q8IYS2
LRAAEDAVWSGATFI	AMDHD2	216	Q9Y303
AESIQWFRDGSLLRS	MYOM3	301	Q5VTT5