Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyBiologicalProcess	virion assembly	CHMP1B DDX6 CHMP1A	2.58e-05	35	34	3	GO:0019068
GeneOntologyBiologicalProcess	ESCRT III complex disassembly	CHMP1B CHMP1A	1.18e-04	10	34	2	GO:1904903
GeneOntologyBiologicalProcess	ESCRT complex disassembly	CHMP1B CHMP1A	1.18e-04	10	34	2	GO:1904896
GeneOntologyBiologicalProcess	vesicle fusion with vacuole	CHMP1B CHMP1A	2.03e-04	13	34	2	GO:0051469
GeneOntologyBiologicalProcess	multivesicular body-lysosome fusion	CHMP1B CHMP1A	2.03e-04	13	34	2	GO:0061763
GeneOntologyBiologicalProcess	vacuole fusion	CHMP1B CHMP1A	2.37e-04	14	34	2	GO:0097576
GeneOntologyBiologicalProcess	viral budding from plasma membrane	CHMP1B CHMP1A	2.37e-04	14	34	2	GO:0046761
GeneOntologyBiologicalProcess	non-lytic viral release	CHMP1B CHMP1A	2.73e-04	15	34	2	GO:0046753
GeneOntologyCellularComponent	amphisome membrane	CHMP1B CHMP1A	1.98e-04	13	34	2	GO:1904930
GeneOntologyCellularComponent	ESCRT III complex	CHMP1B CHMP1A	2.31e-04	14	34	2	GO:0000815
GeneOntologyCellularComponent	amphisome	CHMP1B CHMP1A	2.66e-04	15	34	2	GO:0044753
GeneOntologyCellularComponent	kinetochore microtubule	CHMP1B CHMP1A	5.81e-04	22	34	2	GO:0005828
GeneOntologyCellularComponent	autophagosome	RAB23 CHMP1B CHMP1A	9.46e-04	119	34	3	GO:0005776
GeneOntologyCellularComponent	multivesicular body membrane	CHMP1B CHMP1A	1.09e-03	30	34	2	GO:0032585
GeneOntologyCellularComponent	ESCRT complex	CHMP1B CHMP1A	1.24e-03	32	34	2	GO:0036452
Domain	HTH_psq	LCORL LCOR	3.22e-06	2	34	2	PF05225
Domain	Snf7_fam	CHMP1B CHMP1A	2.10e-04	12	34	2	IPR005024
Domain	Snf7	CHMP1B CHMP1A	2.10e-04	12	34	2	PF03357
Domain	HTH_Psq	LCORL LCOR	2.10e-04	12	34	2	IPR007889
Domain	HTH_PSQ	LCORL LCOR	2.10e-04	12	34	2	PS50960
Pubmed	Identification and characterization of Mlr1,2: two mouse homologues of Mblk-1, a transcription factor from the honeybee brain(1).	LCORL LCOR	9.84e-07	2	35	2	12560079
Pubmed	Mutations in LZTR1 drive human disease by dysregulating RAS ubiquitination.	RAB23 CHMP1B DDX6	2.69e-06	27	35	3	30442762
Pubmed	CHMP1 is a novel nuclear matrix protein affecting chromatin structure and cell-cycle progression.	CHMP1B CHMP1A	2.95e-06	3	35	2	11559747
Pubmed	Splicing variants of NOL4 differentially regulate the transcription activity of Mlr1 and Mlr2 in cultured cells.	LCORL LCOR	2.95e-06	3	35	2	25366156
Pubmed	Essential role of hIST1 in cytokinesis.	CHMP1B CHMP1A	1.47e-05	6	35	2	19129480
Pubmed	ESCRT-III binding protein MITD1 is involved in cytokinesis and has an unanticipated PLD fold that binds membranes.	CHMP1B CHMP1A	1.47e-05	6	35	2	23045692
Pubmed	Interaction of AMSH with ESCRT-III and deubiquitination of endosomal cargo.	CHMP1B CHMP1A	1.47e-05	6	35	2	16760479
Pubmed	A pathogenic CtBP1 missense mutation causes altered cofactor binding and transcriptional activity.	LCORL LCOR	1.47e-05	6	35	2	31041561
Pubmed	ESCRT-III recognition by VPS4 ATPases.	CHMP1B CHMP1A	1.47e-05	6	35	2	17928862
Pubmed	Biochemical analyses of human IST1 and its function in cytokinesis.	CHMP1B CHMP1A	2.06e-05	7	35	2	19129479
Pubmed	Ab initio protein modelling reveals novel human MIT domains.	CHMP1B CHMP1A	2.74e-05	8	35	2	19302785
Pubmed	CHMP1 functions as a member of a newly defined family of vesicle trafficking proteins.	CHMP1B CHMP1A	2.74e-05	8	35	2	11559748
Pubmed	Comprehensive analysis of the human ESCRT-III-MIT domain interactome reveals new cofactors for cytokinetic abscission.	CHMP1B CHMP1A	5.38e-05	11	35	2	36107470
Pubmed	Functional multivesicular bodies are required for autophagic clearance of protein aggregates associated with neurodegenerative disease.	CHMP1B CHMP1A	5.38e-05	11	35	2	17984323
Pubmed	The MIT domain of UBPY constitutes a CHMP binding and endosomal localization signal required for efficient epidermal growth factor receptor degradation.	CHMP1B CHMP1A	5.38e-05	11	35	2	17711858
Pubmed	Large-scale proteomics and phosphoproteomics of urinary exosomes.	FAM20C IDH1 CUBN GNG5 DSG3 CHMP1B CHMP1A	5.85e-05	1016	35	7	19056867
Pubmed	Structure of cellular ESCRT-III spirals and their relationship to HIV budding.	CHMP1B CHMP1A	6.45e-05	12	35	2	24878737
Pubmed	FISH mapping of three ammonia metabolism genes (Glul, Cps1, Glud1) in rat, and the chromosomal localization of GLUL in human and Cps1 in mouse.	IDH1 CPS1	7.62e-05	13	35	2	9107685
Pubmed	ESCRT machinery is required for plasma membrane repair.	CHMP1B CHMP1A	7.62e-05	13	35	2	24482116
Pubmed	The ESCRT-III subunit hVps24 is required for degradation but not silencing of the epidermal growth factor receptor.	CHMP1B CHMP1A	7.62e-05	13	35	2	16554368
Pubmed	ESCRT-III controls nuclear envelope reformation.	CHMP1B CHMP1A	8.89e-05	14	35	2	26040713
Pubmed	AIP1/ALIX is a binding partner for HIV-1 p6 and EIAV p9 functioning in virus budding.	CHMP1B CHMP1A	1.02e-04	15	35	2	14505569
Pubmed	Membrane scission by the ESCRT-III complex.	CHMP1B CHMP1A	1.02e-04	15	35	2	19234443
Pubmed	Spastin and ESCRT-III coordinate mitotic spindle disassembly and nuclear envelope sealing.	CHMP1B CHMP1A	1.02e-04	15	35	2	26040712
Pubmed	Recycling of ESCRTs by the AAA-ATPase Vps4 is regulated by a conserved VSL region in Vta1.	CHMP1B CHMP1A	1.02e-04	15	35	2	16505166
Pubmed	Human ESCRT-III and VPS4 proteins are required for centrosome and spindle maintenance.	CHMP1B CHMP1A	1.02e-04	15	35	2	20616062
Pubmed	The protein network of HIV budding.	CHMP1B CHMP1A	1.49e-04	18	35	2	14505570
Pubmed	A Family of Vertebrate-Specific Polycombs Encoded by the LCOR/LCORL Genes Balance PRC2 Subtype Activities.	LCORL LCOR	1.49e-04	18	35	2	29628311
Pubmed	Divergent retroviral late-budding domains recruit vacuolar protein sorting factors by using alternative adaptor proteins.	CHMP1B CHMP1A	1.49e-04	18	35	2	14519844
Pubmed	Identification of Dll1 (Delta1) target genes during mouse embryogenesis using differential expression profiling.	BNIP3 DDX6	1.85e-04	20	35	2	15979417
Pubmed	Common genetic loci influencing plasma homocysteine concentrations and their effect on risk of coronary artery disease.	CUBN CPS1	1.85e-04	20	35	2	23824729
Pubmed	Short-chain 3-hydroxyacyl-coenzyme A dehydrogenase associates with a protein super-complex integrating multiple metabolic pathways.	IDH1 CUBN CPS1	3.20e-04	132	35	3	22496890
Pubmed	Identification by proximity labeling of novel lipidic and proteinaceous potential partners of the dopamine transporter.	SLC6A3 IDH1	3.40e-04	27	35	2	34709416
Pubmed	The DNA sequence and comparative analysis of human chromosome 10.	BNIP3 CUBN LCOR C10orf67	3.91e-04	345	35	4	15164054
Pubmed	Membrane budding and scission by the ESCRT machinery: it's all in the neck.	CHMP1B CHMP1A	3.93e-04	29	35	2	20588296
Pubmed	Redifferentiation of dedifferentiated chondrocytes and chondrogenesis of human bone marrow stromal cells via chondrosphere formation with expression profiling by large-scale cDNA analysis.	RAB23 PPM1D	5.41e-04	34	35	2	12878157
Pubmed	Polymorphism in the IL18 gene and epithelial ovarian cancer in non-Hispanic white women.	MUC16 MSH2 CYSLTR1	6.69e-04	170	35	3	19064572
Pubmed	Transcription factor protein interactomes reveal genetic determinants in heart disease.	MSH2 CPS1 LCORL CHMP1A	7.53e-04	411	35	4	35182466
Pubmed	Genome-wide association with MRI atrophy measures as a quantitative trait locus for Alzheimer's disease.	CUBN ZNF292	8.66e-04	43	35	2	21116278
Pubmed	Combinatorial CRISPR screen identifies fitness effects of gene paralogues.	FNIP1 CHMP1B CHMP1A	8.68e-04	186	35	3	33637726
Cytoband	Ensembl 112 genes in cytogenetic band chr2q34	IDH1 CPS1	5.48e-04	45	35	2	chr2q34
GeneFamily	Charged multivesicular body proteins\|ESCRT-III associated factors	CHMP1B CHMP1A	1.54e-05	5	23	2	1119
GeneFamily	Charged multivesicular body proteins\|ESCRT-III associated factors	CHMP1B CHMP1A	8.45e-05	11	23	2	482
Coexpression	DESCARTES_ORGANOGENESIS_STROMAL_CELLS	MSH2 GNG5 CHMP1B PPM1D DDX6	6.79e-06	201	35	5	MM3652
CoexpressionAtlas	DevelopingGonad_e16.5_epididymis_emap-29702_k-means-cluster#3_top-relative-expression-ranked_500	FNIP1 LCORL LCOR	5.55e-05	45	35	3	gudmap_developingGonad_e16.5_epididymis_500_k3
CoexpressionAtlas	DevelopingGonad_e14.5_ ovary_emap-6699_k-means-cluster#1_top-relative-expression-ranked_200	FNIP1 LCORL LCOR	5.55e-05	45	35	3	gudmap_developingGonad_e14.5_ ovary_200_k1
Disease	homocysteine measurement	CUBN CPS1 CHMP1A	2.05e-05	46	34	3	EFO_0004578
Disease	Glioma	MSH2 IDH1 PPM1D	1.39e-04	87	34	3	C0017638
Disease	Cardiovascular Abnormalities	DDX6 ZNF292	1.53e-04	16	34	2	C0243050
Disease	albuminuria	CUBN CPS1 COG3	1.74e-04	94	34	3	EFO_0004285
Disease	Attention deficit hyperactivity disorder	SLC6A3 ZNF292	3.50e-04	24	34	2	C1263846
Disease	Breast Cancer, Familial	MSH2 PPM1D	5.49e-04	30	34	2	C0346153
Disease	fibrinogen measurement, tissue plasminogen activator measurement	FNIP1 CPS1	1.24e-03	45	34	2	EFO_0004623, EFO_0004791
Disease	fibrinogen measurement, plasminogen activator inhibitor 1 measurement	FNIP1 CPS1	1.24e-03	45	34	2	EFO_0004623, EFO_0004792
Disease	factor XI measurement, fibrinogen measurement, tissue plasminogen activator measurement, factor VII measurement	FNIP1 CPS1	1.91e-03	56	34	2	EFO_0004619, EFO_0004623, EFO_0004694, EFO_0004791
Disease	response to opioid	MUC16 MSH2	2.26e-03	61	34	2	EFO_0008541
Disease	urolithiasis	NIPAL2 CPS1	2.41e-03	63	34	2	MONDO_0024647

Protein segments in the cluster

Peptide	Gene	Start	Entry
QVSKHMGGAKVMATT	DDX6	186	P26196
TAANTSLMGIKMTTV	ANKRD17	1826	O75179
KMVVVGNGAVGKSSM	RAB23	11	Q9ULC3
VQTAVTMKGVTKNMA	CHMP1A	76	Q9HD42
TAVTMGKVTKSMAGV	CHMP1B	81	Q7LBR1
GKVTKSMAGVVKSMD	CHMP1B	86	Q7LBR1
SMAGVVKSMDATLKT	CHMP1B	91	Q7LBR1
TAVEGTSGMEMTTKL	DSG3	711	P32926
TTKATSAMGTISIMG	MUC16	7501	Q8WXI7
MASQKQMEVVTKGTG	C22orf23	1	Q9BZE7
MVMSGKMSVSKAQGI	LCORL	536	Q8N3X6
EAISVVMSGKMSVSK	LCOR	356	Q96JN0
MSGSSSVAAMKKVVQ	GNG5	1	P63218
SGTTASVVIIRGMKM	PPM1D	171	O15297
SSMSTAMVIFKSGVV	CUBN	3366	O60494
SRIGSSMKSVGEVMA	CPS1	786	P31327
MSKKISGGSVVEMQG	IDH1	1	O75874
VGSMNSKRSAMGTVV	KLHL18	366	O94889
ATLSMRNTSVMKKGG	BNIP3	141	Q12983
VAMKSGGTQLKLIMT	FAM20C	261	Q8IXL6
MTKVSALKTMASQGG	COG3	716	Q96JB2
SHTGKAMRSTGMVVE	FNIP1	716	Q8TF40
MSASIGVVGVKMSAV	MSH2	141	P43246
TGMESSKSMTVKVSA	PSG3	401	Q16557
MTKSHSGVTKFSGMV	NR1D2	86	Q14995
TKEVVSSGVTGAMDM	PLIN4	121	Q96Q06
KTSGAMPTGSMKAVA	RTL9	471	Q8NET4
TAVATAVGMNMLTKK	SFXN2	156	Q96NB2
SVSEMKSSGKMNGLV	ARHGAP42	301	A6NI28
VKAVSGMITFSVMDK	NIPAL2	226	Q9H841
SSHKKAIGMIMVVTA	CYSLTR1	226	Q9Y271
ATMSVSSAGAQKAKM	C10orf67	376	Q8IYJ2
SSKRMMKEVLSTGQG	ZNF578	66	Q96N58
MSKSKCSVGLMSSVV	SLC6A3	1	Q01959
MSVMKDISIGKATGR	ZNF292	2706	O60281
LGDEMTGLVMTKTKT	MYCBPAP	276	Q8TBZ2
TGLVMTKTKTQRGLM	MYCBPAP	281	Q8TBZ2
SIRMTKGITMATAKA	TLN2	2176	Q9Y4G6