Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyBiologicalProcessnegative regulation of phospholipase A2 activity

ANXA8 ANXA8L1

8.88e-063362GO:1900138
GeneOntologyBiologicalProcessnegative regulation of phospholipase activity

ANXA8 ANXA8L1

2.95e-055362GO:0010519
GeneOntologyBiologicalProcessregulation of microtubule polymerization or depolymerization

SPECC1L ABL1 NME7 PDE4DIP

3.68e-05108364GO:0031110
GeneOntologyBiologicalProcesscytoskeleton-dependent intracellular transport

KIF13B IFT140 NME7 IFT172 PURA

4.23e-05225365GO:0030705
GeneOntologyBiologicalProcessmicrotubule-based process

KIF13B IFT140 SPECC1L ABL1 NME7 DNAH10 IFT172 PURA PDE4DIP

6.37e-051058369GO:0007017
GeneOntologyBiologicalProcessnegative regulation of serine-type peptidase activity

ANXA8 ANXA8L1

8.24e-058362GO:1902572
GeneOntologyBiologicalProcessnegative regulation of serine-type endopeptidase activity

ANXA8 ANXA8L1

8.24e-058362GO:1900004
GeneOntologyBiologicalProcessintraciliary transport

IFT140 NME7 IFT172

1.08e-0453363GO:0042073
GeneOntologyBiologicalProcessregulation of serine-type peptidase activity

ANXA8 ANXA8L1

1.32e-0410362GO:1902571
GeneOntologyBiologicalProcessregulation of phospholipase A2 activity

ANXA8 ANXA8L1

1.32e-0410362GO:0032429
GeneOntologyBiologicalProcessregulation of serine-type endopeptidase activity

ANXA8 ANXA8L1

1.32e-0410362GO:1900003
GeneOntologyBiologicalProcessregulation of epithelial cell apoptotic process

SAV1 AKR1C4 ABL1 PDCD4

1.39e-04152364GO:1904035
GeneOntologyBiologicalProcesspositive regulation of epithelial cell apoptotic process

SAV1 AKR1C4 PDCD4

1.56e-0460363GO:1904037
GeneOntologyBiologicalProcessmicrotubule-based movement

KIF13B IFT140 NME7 DNAH10 IFT172 PURA

1.92e-04493366GO:0007018
GeneOntologyBiologicalProcessmicrotubule polymerization or depolymerization

SPECC1L ABL1 NME7 PDE4DIP

2.04e-04168364GO:0031109
GeneOntologyBiologicalProcessregulation of microtubule polymerization

ABL1 NME7 PDE4DIP

2.36e-0469363GO:0031113
GeneOntologyBiologicalProcessregulation of microtubule cytoskeleton organization

SPECC1L ABL1 NME7 PDE4DIP

2.44e-04176364GO:0070507
GeneOntologyBiologicalProcessnegative regulation of lipase activity

ANXA8 ANXA8L1

2.66e-0414362GO:0060192
GeneOntologyBiologicalProcessregulation of endothelial cell apoptotic process

AKR1C4 ABL1 PDCD4

2.91e-0474363GO:2000351
GeneOntologyBiologicalProcessepithelial cell apoptotic process

SAV1 AKR1C4 ABL1 PDCD4

3.40e-04192364GO:1904019
GeneOntologyBiologicalProcessendothelial cell apoptotic process

AKR1C4 ABL1 PDCD4

3.52e-0479363GO:0072577
GeneOntologyBiologicalProcesstransport along microtubule

IFT140 NME7 IFT172 PURA

3.74e-04197364GO:0010970
GeneOntologyBiologicalProcessneural tube development

IFT140 SPECC1L ABL1 IFT172

4.11e-04202364GO:0021915
GeneOntologyBiologicalProcessregulation of microtubule nucleation

NME7 PDE4DIP

4.97e-0419362GO:0010968
GeneOntologyBiologicalProcessregulation of phospholipase activity

ANXA8 ANXA8L1

6.69e-0422362GO:0010517
GeneOntologyBiologicalProcesscellular response to prostaglandin stimulus

AKR1C4 ACACA

7.32e-0423362GO:0071379
GeneOntologyBiologicalProcessintracellular transport

KIF13B IFT140 RBM22 ANXA8 NME7 ATP2A2 IFT172 PURA ANXA8L1

8.50e-041496369GO:0046907
GeneOntologyBiologicalProcessimmature B cell differentiation

ATP11C ABL1

8.66e-0425362GO:0002327
GeneOntologyBiologicalProcessmicrotubule-based transport

IFT140 NME7 IFT172 PURA

9.56e-04253364GO:0099111
GeneOntologyBiologicalProcesspositive regulation of chromosome organization

NCAPD3 PARN ATF7IP

1.00e-03113363GO:2001252
GeneOntologyBiologicalProcessneural tube closure

SPECC1L ABL1 IFT172

1.00e-03113363GO:0001843
GeneOntologyBiologicalProcesstube closure

SPECC1L ABL1 IFT172

1.03e-03114363GO:0060606
GeneOntologyBiologicalProcesschromosome organization

NCAPD3 PARN ABL1 TEP1 ATF7IP PURA

1.10e-03686366GO:0051276
GeneOntologyBiologicalProcessmicrotubule polymerization

ABL1 NME7 PDE4DIP

1.11e-03117363GO:0046785
GeneOntologyCellularComponentplasma membrane bounded cell projection cytoplasm

IFT140 NME7 DNAH10 IFT172 PURA

1.99e-04317365GO:0032838
GeneOntologyCellularComponentcytoplasmic region

IFT140 NME7 DNAH10 IFT172 PURA

3.58e-04360365GO:0099568
GeneOntologyCellularComponentaxoneme

IFT140 NME7 DNAH10 IFT172

4.29e-04207364GO:0005930
GeneOntologyCellularComponentciliary plasm

IFT140 NME7 DNAH10 IFT172

4.37e-04208364GO:0097014
GeneOntologyCellularComponentintraciliary transport particle

IFT140 IFT172

1.06e-0328362GO:0030990
DomainAnnexinVIII

ANXA8 ANXA8L1

3.82e-062372IPR009115
DomainAnnexin

ANXA8 ANXA8L1

2.94e-0413372PF00191
DomainANX

ANXA8 ANXA8L1

2.94e-0413372SM00335
DomainANNEXIN

ANXA8 ANXA8L1

2.94e-0413372PS00223
DomainAnnexin_repeat

ANXA8 ANXA8L1

2.94e-0413372IPR018502
Domain-

ANXA8 ANXA8L1

2.94e-04133721.10.220.10
DomainAnnexin_repeat_CS

ANXA8 ANXA8L1

2.94e-0413372IPR018252
DomainAnnexin

ANXA8 ANXA8L1

3.42e-0414372IPR001464
DomainPentatricopeptide_repeat

IFT140 PDCD4

9.41e-0423372IPR002885
Domain-

ATP11C ATP2A2

1.82e-03323722.70.150.10
Domain-

ATP11C ATP2A2

1.82e-03323723.40.1110.10
DomainATPase_P-typ_cyto_domN

ATP11C ATP2A2

2.18e-0335372IPR023299
DomainATPase_P-typ_P_site

ATP11C ATP2A2

2.31e-0336372IPR018303
DomainP_typ_ATPase

ATP11C ATP2A2

2.31e-0336372IPR001757
DomainATPASE_E1_E2

ATP11C ATP2A2

2.31e-0336372PS00154
DomainATPase_P-typ_transduc_dom_A

ATP11C ATP2A2

2.43e-0337372IPR008250
DomainE1-E2_ATPase

ATP11C ATP2A2

2.43e-0337372PF00122
DomainTPR

IFT140 DNAH10 IFT172

4.22e-03165373PS50005
DomainTPR_REGION

IFT140 DNAH10 IFT172

4.22e-03165373PS50293
DomainARM-type_fold

USP34 NCAPD3 IFT172 PDCD4

4.39e-03339374IPR016024
DomainHMG_box

UBTF HMG20A

4.94e-0353372PF00505
DomainHMG_BOX_2

UBTF HMG20A

5.12e-0354372PS50118
DomainHMG

UBTF HMG20A

5.12e-0354372SM00398
Domain-

UBTF HMG20A

5.31e-03553721.10.30.10
DomainHMG_box_dom

UBTF HMG20A

7.34e-0365372IPR009071
DomainHAD-like_dom

ATP11C ATP2A2

1.07e-0279372IPR023214
Pubmed

Annexins: linking Ca2+ signalling to membrane dynamics.

ANXA8 ANXA8L1

1.10e-06237215928709
Pubmed

TaqI polymorphisms at the annexin VIII locus (ANX8).

ANXA8 ANXA8L1

1.10e-0623721364010
Pubmed

Annexin A8 controls leukocyte recruitment to activated endothelial cells via cell surface delivery of CD63.

ANXA8 ANXA8L1

1.10e-06237224769558
Pubmed

Annexins: from structure to function.

ANXA8 ANXA8L1

1.10e-06237211917092
Pubmed

Cooperative binding promotes demand-driven recruitment of AnxA8 to cholesterol-containing membranes.

ANXA8 ANXA8L1

1.10e-06237229306076
Pubmed

Annexin A8 identifies a subpopulation of transiently quiescent c-kit positive luminal progenitor cells of the ductal mammary epithelium.

ANXA8 ANXA8L1

1.10e-06237225803307
Pubmed

Bone matrix regulates osteoclast differentiation and annexin A8 gene expression.

ANXA8 ANXA8L1

1.10e-06237221344395
Pubmed

Annexin A8 is up-regulated during mouse mammary gland involution and predicts poor survival in breast cancer.

ANXA8 ANXA8L1

1.10e-06237216203777
Pubmed

Specific expression of annexin A8 in adult murine stratified epithelia.

ANXA8 ANXA8L1

3.30e-06337217082908
Pubmed

Vascular anticoagulant beta: a novel human Ca2+/phospholipid binding protein that inhibits coagulation and phospholipase A2 activity. Its molecular cloning, expression and comparison with VAC-alpha.

ANXA8 ANXA8L1

3.30e-0633722530088
Pubmed

A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.

USP34 NCAPD3 SPECC1L ECSIT ATP2A2 PTGFRN UBTF PDCD4 PURA

1.52e-05144037930833792
Pubmed

SHLD2/FAM35A co-operates with REV7 to coordinate DNA double-strand break repair pathway choice.

NCAPD3 PARN ATP2A2 PURA

1.97e-0515037430154076
Pubmed

The genetic origin of mouse annexin VIII.

ANXA8 ANXA8L1

2.30e-0573729434938
Pubmed

Transcriptome analysis of mouse stem cells and early embryos.

USP34 CCPG1 ABL1 ACACA PDE4DIP

3.99e-0536337514691545
Pubmed

LRRC31 inhibits DNA repair and sensitizes breast cancer brain metastasis to radiation therapy.

NCAPD3 SPECC1L ACACA ATP2A2

6.28e-0520237433005030
Pubmed

The deubiquitinase TRABID stabilizes the K29/K48-specific E3 ubiquitin ligase HECTD1.

USP34 NCAPD3 SPECC1L ACACA

7.57e-0521237433853758
Pubmed

Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS.

SAV1 USP34 ACACA ATP2A2 PDE4DIP

9.08e-0543237523455922
Pubmed

DNA Repair Network Analysis Reveals Shieldin as a Key Regulator of NHEJ and PARP Inhibitor Sensitivity.

USP34 NCAPD3 PARN SPECC1L ATP2A2

1.13e-0445337529656893
Pubmed

Energy stress-induced lncRNA FILNC1 represses c-Myc-mediated energy metabolism and inhibits renal tumor development.

ATP2A2 PDCD4 PURA

1.22e-049037328978906
Pubmed

Characterization of mouse IFT complex B.

IFT140 IFT172

2.07e-042037219253336
Pubmed

TEAD-1 overexpression in the mouse heart promotes an age-dependent heart dysfunction.

ATP2A2 PURA

2.28e-042137220194497
Pubmed

NMRK2 Gene Is Upregulated in Dilated Cardiomyopathy and Required for Cardiac Function and NAD Levels during Aging.

NMRK2 ATP2A2

2.28e-042137233805532
Pubmed

Combinatorial targeting of a chromatin complex comprising Dot1L, menin and the tyrosine kinase BAZ1B reveals a new therapeutic vulnerability of endocrine therapy-resistant breast cancer.

NCAPD3 CCPG1 SPECC1L ATP2A2 UBTF PURA

2.50e-0484737635850772
Pubmed

ATMIN is a transcriptional regulator of both lung morphogenesis and ciliogenesis.

IFT140 IFT172

2.51e-042237225294941
Pubmed

Candidate downstream regulated genes of HOX group 13 transcription factors with and without monomeric DNA binding capability.

ANXA8 ANXA8L1

2.51e-042237215733672
Pubmed

Use of expression data and the CGEMS genome-wide breast cancer association study to identify genes that may modify risk in BRCA1/2 mutation carriers.

ABL1 VNN2

2.51e-042237218095154
Pubmed

Leber Congenital Amaurosis / Early-Onset Severe Retinal Dystrophy Overview

IFT140 DTHD1

3.25e-042537230285347
Pubmed

Cilia gene mutations cause atrioventricular septal defects by multiple mechanisms.

IFT140 IFT172

3.25e-042537227340223
Pubmed

Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity.

SAV1 USP34 PARN ABL1 PURA PDE4DIP

3.67e-0491037636736316
Pubmed

Osteocyte transcriptome mapping identifies a molecular landscape controlling skeletal homeostasis and susceptibility to skeletal disease.

ANXA8 ANXA8L1

4.09e-042837233953184
Pubmed

FBW7 suppresses ovarian cancer development by targeting the N6-methyladenosine binding protein YTHDF2.

SPECC1L ATP2A2 UBTF PURA HMG20A

4.18e-0460137533658012
Pubmed

An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.

SAV1 KIF13B IFT140 ECSIT NME7 IFT172 HMG20A

4.25e-04132137727173435
Pubmed

Biology, structure and mechanism of P-type ATPases.

ATP11C ATP2A2

4.39e-042937215071553
Pubmed

Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.

KIF13B PARN SPECC1L ATF7IP PURA PDE4DIP

4.95e-0496337628671696
Pubmed

The NANCI-Nkx2.1 gene duplex buffers Nkx2.1 expression to maintain lung development and homeostasis.

ANXA8 ANXA8L1

5.35e-043237228546511
Pubmed

Inceptor counteracts insulin signalling in β-cells to control glycaemia.

ABL1 ACACA

6.05e-043437233505018
Pubmed

LKB1 deletion causes early changes in atrial channel expression and electrophysiology prior to atrial fibrillation.

ACACA ATP2A2

6.05e-043437226378152
Pubmed

Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.

USP34 PARN ACACA ATP2A2 UBTF

6.09e-0465337522586326
Pubmed

Human transcription factor protein interaction networks.

ZNF420 DNAH10 ATP2A2 UBTF ATF7IP PURA HMG20A

6.79e-04142937735140242
Pubmed

A systems wide mass spectrometric based linear motif screen to identify dominant in-vivo interacting proteins for the ubiquitin ligase MDM2.

ATP2A2 UBTF

7.16e-043737224583282
Pubmed

Pro-prion, as a membrane adaptor protein for E3 ligase c-Cbl, facilitates the ubiquitination of IGF-1R, promoting melanoma metastasis.

SAV1 NCAPD3 CCPG1 PURA PDE4DIP

7.76e-0468937536543142
Pubmed

Human variation in alcohol response is influenced by variation in neuronal signaling genes.

KIF13B AKR1C4 ABL1

8.02e-0417137320201926
Pubmed

Cell cycle-related kinase is a crucial regulator for ciliogenesis and Hedgehog signaling in embryonic mouse lung development.

IFT140 IFT172

8.37e-044037232317081
Pubmed

The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.

NCAPD3 RBM22 PARN SPECC1L ATP2A2 PURA HMG20A

8.93e-04149737731527615
Pubmed

Hepatitis C virus enters liver cells using the CD81 receptor complex proteins calpain-5 and CBLB.

CAPN5 PTGFRN

1.01e-034437230024968
Cytoband10q11.22

ANXA8 ANXA8L1

5.08e-044137210q11.22
GeneFamilyAnnexins|Endogenous ligands

ANXA8 ANXA8L1

1.20e-0413232404
GeneFamilyIntraflagellar transport proteins|Tetratricopeptide repeat domain containing

IFT140 IFT172

4.20e-0424232615
GeneFamilyWD repeat domain containing

IFT140 TEP1 IFT172

4.30e-03262233362
CoexpressionGSE13738_TCR_VS_BYSTANDER_ACTIVATED_CD4_TCELL_UP

NME7 PTGFRN VNN2 HDC HMG20A

8.38e-06198375M3324
CoexpressionGSE40274_XBP1_VS_FOXP3_AND_XBP1_TRANSDUCED_ACTIVATED_CD4_TCELL_UP

KIF13B GIMAP4 CCPG1 PDCD4 PDE4DIP

8.79e-06200375M9161
CoexpressionCASTELLANO_HRAS_AND_NRAS_TARGETS_UP

ANXA8 ANXA8L1

5.40e-058372MM1086
CoexpressionZAK_PBMC_MRKAD5_HIV_1_GAG_POL_NEF_AGE_20_50YO_1DY_DN

USP34 NCAPD3 ZNF420 SPECC1L DTHD1 UBTF PDCD4 PDE4DIP

6.84e-051012378M40864
CoexpressionJINESH_BLEBBISHIELD_TRANSFORMED_STEM_CELL_SPHERES_UP

ANXA8 CCPG1 AKR1C4 ATP2A2

9.54e-05170374M38971
CoexpressionMTOR_UP.N4.V1_DN

IFT140 VNN2 ATF7IP PDCD4

1.30e-04184374M2756
CoexpressionPARENT_MTOR_SIGNALING_UP

USP34 IFT140 AKR1C4 ATF7IP PDCD4 PDE4DIP

1.31e-04567376M16909
CoexpressionGSE20727_DNFB_ALLERGEN_VS_ROS_INH_AND_DNFB_ALLERGEN_TREATED_DC_UP

SAV1 SPECC1L ZNF789 PURA

1.65e-04196374M9241
CoexpressionGSE17580_UNINFECTED_VS_S_MANSONI_INF_TREG_UP

GIMAP4 RBM22 IFT172 PURA

1.75e-04199374M3677
CoexpressionGSE360_T_GONDII_VS_M_TUBERCULOSIS_MAC_UP

SPECC1L ABL1 ATP2A2 UBTF

1.75e-04199374M5258
CoexpressionGSE37533_PPARG1_FOXP3_VS_PPARG2_FOXP3_TRANSDUCED_CD4_TCELL_DN

GIMAP4 RBM22 TEP1 HMG20A

1.78e-04200374M8997
CoexpressionGSE27786_BCELL_VS_MONO_MAC_UP

USP34 IFT140 UBTF PDE4DIP

1.78e-04200374M4817
CoexpressionGSE2128_C57BL6_VS_NOD_CD4CD8_DP_THYMOCYTE_DN

SAV1 IFT140 ECSIT HMG20A

1.78e-04200374M6184
CoexpressionGSE40273_GATA1_KO_VS_WT_TREG_DN

GIMAP4 IFT140 TEP1 PURA

1.78e-04200374M9133
CoexpressionGSE40274_CTRL_VS_FOXP3_TRANSDUCED_ACTIVATED_CD4_TCELL_DN

GIMAP4 IFT140 CCPG1 ATF7IP

1.78e-04200374M9136
CoexpressionGSE22432_UNTREATED_VS_TGFB1_TREATED_COMMON_DC_PROGENITOR_DN

GIMAP4 ATP11C CCPG1 PDCD4

1.78e-04200374M7828
DrugAC1L1AV8

ACACA ATP2A2 UBTF IFT172

9.17e-0746374CID000001163
DiseaseMainzer-Saldino Disease

IFT140 IFT172

1.45e-062362C1849437
Disease5alpha-androstan-3beta,17alpha-diol disulfate measurement

AKR1C4 ZNF789

6.47e-0510362EFO_0800289
DiseaseJeune thoracic dystrophy

IFT140 IFT172

7.90e-0511362C0265275
DiseaseShort Rib-Polydactyly Syndrome

IFT140 IFT172

1.12e-0413362C0036996
Disease5alpha-androstan-3alpha,17alpha-diol monosulfate measurement

AKR1C4 ZNF789

1.30e-0414362EFO_0800283
DiseaseSaldino-Noonan Syndrome

IFT140 IFT172

1.30e-0414362C0036069
DiseaseMajewski Syndrome

IFT140 IFT172

1.30e-0414362C0024507
Disease5alpha-androstan-3beta,17beta-diol disulfate measurement

AKR1C4 ZNF789

3.29e-0422362EFO_0021115
DiseaseGastrointestinal Stromal Sarcoma

NME7 IFT172

1.51e-0347362C3179349
DiseaseGastrointestinal Stromal Tumors

NME7 IFT172

1.71e-0350362C0238198
Diseaseneuropsychological test

SAV1 NCAPD3 CAPN5

1.78e-03197363EFO_0003926

Protein segments in the cluster

PeptideGeneStartEntry
EDMKVLDGLNRNYRY

AKR1C4

291

P17516
EDVKSGRYMELEQRY

SPECC1L

481

Q69YQ0
EEERGRVYNYMNAVE

SPECC1L

801

Q69YQ0
YMKEEVDRYRITIGN

ACACA

726

Q13085
FDIYKVEENRQYRMH

CAPN5

426

O15484
DVNKEYYTQNMEREI

RBM22

111

Q9NW64
IQTYAEYMGRKQEEK

PARN

506

O95453
NQLREIMKAYEEDYG

ANXA8

126

P13928
EYRERGREMVDYICQ

HDC

6

P19113
ERYMKELEQYQKTEA

HMG20A

161

Q9NP66
ITVDQMKRGYERIYN

PDCD4

396

Q53EL6
MEKQGKYREAERLYV

IFT172

981

Q9UG01
EYEPEMGKVYRQDRK

ATP2A2

121

P16615
VNDVKDYLRNMKEYE

CCPG1

701

Q9ULG6
NQLREIMKAYEEDYG

ANXA8L1

126

Q5VT79
SQVYELLEKDYRMER

ABL1

446

P00519
EYEIFKMEQDARGRY

APCDD1

421

Q8J025
RYRGNYRDIMVKVCD

DTHD1

246

Q6ZMT9
QSKRRRYMEEEYEAE

ATF7IP

566

Q6VMQ6
VGRTMKEYEDRKYEQ

DNAH10

611

Q8IVF4
DMIEAARYYEEKGVQ

IFT140

1066

Q96RY7
ARYYEEKGVQMDRAV

IFT140

1071

Q96RY7
KMREYGVERDLAVYN

ECSIT

116

Q9BQ95
MDRVNVEEFYEVYKG

NME7

276

Q9Y5B8
YRQEMEANGVEVVYL

NMRK2

156

Q9NPI5
EKVQEDEFRYRMYQT

PTGFRN

631

Q9P2B2
VEVSYMEIYNEKVRD

KIF13B

146

Q9NQT8
YTNRMYQRAEEEIQK

GIMAP4

221

Q9NUV9
YLREVMQDYRDELKD

NCAPD3

1226

P42695
GYMRVENQRKEIEEY

ATP11C

521

Q8NB49
ELEQIVKMYEAYRQA

SAV1

346

Q9H4B6
YRMLQKEENEVYVLG

VNN2

371

O95498
KYDGEMLNRYRQALE

TEP1

646

Q99973
ENQKEYFRQGMIIYD

ZNF420

101

Q8TAQ5
YKRMEPEEENGREYK

USP34

2236

Q70CQ2
EQRKEYEEIMRDYIQ

UBTF

251

P17480
ENRKYYMDLKENQRG

PURA

151

Q00577
GQKDLYRDVMLENYR

ZNF789

31

Q5FWF6
ERMQQKYEASREDIY

PDE4DIP

31

Q5VU43