Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	clathrin binding	HIP1 NSG2 PIK3C2A GPR107	3.13e-05	63	57	4	GO:0030276
GeneOntologyMolecularFunction	1-phosphatidylinositol-4-phosphate 3-kinase activity	PIK3C2A PIK3C2B	1.67e-04	7	57	2	GO:0035005
GeneOntologyMolecularFunction	clathrin light chain binding	HIP1 NSG2	1.67e-04	7	57	2	GO:0032051
GeneOntologyMolecularFunction	sphingosine-1-phosphate receptor activity	S1PR2 S1PR3	2.22e-04	8	57	2	GO:0038036
GeneOntologyMolecularFunction	1-phosphatidylinositol-3-kinase activity	PIK3C2A PIK3C2B	4.33e-04	11	57	2	GO:0016303
GeneOntologyMolecularFunction	bioactive lipid receptor activity	S1PR2 S1PR3	9.36e-04	16	57	2	GO:0045125
GeneOntologyCellularComponent	trans-Golgi network	FLNA NSG2 PIK3C2A TBC1D23 ASAP1 FCMR	1.82e-04	306	57	6	GO:0005802
Domain	ARM-type_fold	HIP1 PPP2R5C PIK3C2A PIK3C2B RRP12 DAAM2 WDFY3	7.40e-05	339	57	7	IPR016024
Domain	S1P_rcpt	S1PR2 S1PR3	9.10e-05	5	57	2	IPR004061
Domain	HRDC-like	CRCP WRN	9.10e-05	5	57	2	IPR010997
Domain	PI3K_Ras-bd_dom	PIK3C2A PIK3C2B	1.90e-04	7	57	2	IPR000341
Domain	PI3K_rbd	PIK3C2A PIK3C2B	1.90e-04	7	57	2	PF00794
Domain	PI3K_RBD	PIK3C2A PIK3C2B	1.90e-04	7	57	2	PS51546
Domain	PI3K_rbd	PIK3C2A PIK3C2B	1.90e-04	7	57	2	SM00144
Domain	PI3K_C2_dom	PIK3C2A PIK3C2B	2.53e-04	8	57	2	IPR002420
Domain	PI3K_C2	PIK3C2A PIK3C2B	2.53e-04	8	57	2	PF00792
Domain	PI3K_C2	PIK3C2A PIK3C2B	2.53e-04	8	57	2	PS51547
Domain	PI3K_C2	PIK3C2A PIK3C2B	2.53e-04	8	57	2	SM00142
Domain	PI3Ka	PIK3C2A PIK3C2B	3.25e-04	9	57	2	PF00613
Domain	-	PIK3C2A PIK3C2B	3.25e-04	9	57	2	1.25.40.70
Domain	PI3Ka	PIK3C2A PIK3C2B	3.25e-04	9	57	2	SM00145
Domain	PIK_HELICAL	PIK3C2A PIK3C2B	4.05e-04	10	57	2	PS51545
Domain	PI_Kinase	PIK3C2A PIK3C2B	4.05e-04	10	57	2	IPR015433
Domain	PInositide-3_kin_accessory_dom	PIK3C2A PIK3C2B	4.05e-04	10	57	2	IPR001263
Domain	PI3/4_kinase_CS	PIK3C2A PIK3C2B	9.37e-04	15	57	2	IPR018936
Domain	-	PIK3C2A PIK3C2B	1.07e-03	16	57	2	1.10.1070.11
Domain	PI3Kc	PIK3C2A PIK3C2B	1.07e-03	16	57	2	SM00146
Domain	PI3/4_kinase_cat_dom	PIK3C2A PIK3C2B	1.36e-03	18	57	2	IPR000403
Domain	PI3_PI4_kinase	PIK3C2A PIK3C2B	1.36e-03	18	57	2	PF00454
Domain	PI3_4_KINASE_3	PIK3C2A PIK3C2B	1.36e-03	18	57	2	PS50290
Domain	PI3_4_KINASE_1	PIK3C2A PIK3C2B	1.36e-03	18	57	2	PS00915
Domain	PI3_4_KINASE_2	PIK3C2A PIK3C2B	1.36e-03	18	57	2	PS00916
Domain	Ubiquitin-rel_dom	PIK3C2A PIK3C2B RASSF4 IQUB	2.40e-03	184	57	4	IPR029071
Domain	-	PPP2R5C RRP12 DAAM2 WDFY3	4.69e-03	222	57	4	1.25.10.10
Domain	C2	RASA1 PIK3C2A PIK3C2B	7.49e-03	131	57	3	PF00168
Domain	PX	PIK3C2A PIK3C2B	7.97e-03	44	57	2	SM00312
Domain	C2	RASA1 PIK3C2A PIK3C2B	8.46e-03	137	57	3	SM00239
Domain	ARM-like	PPP2R5C RRP12 DAAM2 WDFY3	9.26e-03	270	57	4	IPR011989
Domain	C2	RASA1 PIK3C2A PIK3C2B	9.33e-03	142	57	3	PS50004
Domain	PX	PIK3C2A PIK3C2B	9.82e-03	49	57	2	PF00787
Domain	PX	PIK3C2A PIK3C2B	1.02e-02	50	57	2	PS50195
Domain	-	RASA1 PIK3C2A PIK3C2B	1.04e-02	148	57	3	2.60.40.150
Domain	-	PIK3C2A PIK3C2B	1.06e-02	51	57	2	3.30.1520.10
Domain	Phox	PIK3C2A PIK3C2B	1.10e-02	52	57	2	IPR001683
Pathway	WP_S1P_RECEPTOR_SIGNAL_TRANSDUCTION	PIK3C2B S1PR2 S1PR3	5.02e-05	25	41	3	M39384
Pubmed	Deafness and stria vascularis defects in S1P2 receptor-null mice.	S1PR2 S1PR3	2.64e-06	2	57	2	17284444
Pubmed	Class II phosphatidylinositol 3-kinase α and β isoforms are required for vascular smooth muscle Rho activation, contraction and blood pressure regulation in mice.	PIK3C2A PIK3C2B	2.64e-06	2	57	2	32192434
Pubmed	Topographical expression of class IA and class II phosphoinositide 3-kinase enzymes in normal human tissues is consistent with a role in differentiation.	PIK3C2A PIK3C2B	2.64e-06	2	57	2	14563213
Pubmed	Evidence for Edg-3 receptor-mediated activation of I(K.ACh) by sphingosine-1-phosphate in human atrial cardiomyocytes.	S1PR2 S1PR3	2.64e-06	2	57	2	10908314
Pubmed	Sphingosine 1-phosphate-induced cell rounding and neurite retraction are mediated by the G protein-coupled receptor H218.	S1PR2 S1PR3	2.64e-06	2	57	2	9988698
Pubmed	Opposing Roles of S1P3 Receptors in Myocardial Function.	S1PR2 S1PR3	2.64e-06	2	57	2	32722120
Pubmed	The sphingosine 1-phosphate receptor S1P2 triggers hepatic wound healing.	S1PR2 S1PR3	2.64e-06	2	57	2	17341687
Pubmed	Sphingosine 1-phosphate S1P2 and S1P3 receptor-mediated Akt activation protects against in vivo myocardial ischemia-reperfusion injury.	S1PR2 S1PR3	2.64e-06	2	57	2	17293497
Pubmed	Sphingosine 1-phosphate (S1P) signaling is required for maintenance of hair cells mainly via activation of S1P2.	S1PR2 S1PR3	2.64e-06	2	57	2	17287522
Pubmed	The class II phosphoinositide 3-kinases PI3K-C2α and PI3K-C2β differentially regulate clathrin-dependent pinocytosis in human vascular endothelial cells.	PIK3C2A PIK3C2B	2.64e-06	2	57	2	30374841
Pubmed	Sphingosine 1-phosphate (S1P) receptor agonists mediate pro-fibrotic responses in normal human lung fibroblasts via S1P2 and S1P3 receptors and Smad-independent signaling.	S1PR2 S1PR3	2.64e-06	2	57	2	23589284
Pubmed	Sphingosine 1-phosphate receptors are essential mediators of eyelid closure during embryonic development.	S1PR2 S1PR3	2.64e-06	2	57	2	24003216
Pubmed	Molecular cloning of the novel human G protein-coupled receptor (GPCR) gene mapped on chromosome 9.	S1PR2 S1PR3	2.64e-06	2	57	2	8878560
Pubmed	Selective coupling of the S1P3 receptor subtype to S1P-mediated RhoA activation and cardioprotection.	S1PR2 S1PR3	2.64e-06	2	57	2	28017639
Pubmed	Sphingosine 1-phosphate-induced cell proliferation, survival, and related signaling events mediated by G protein-coupled receptors Edg3 and Edg5.	S1PR2 S1PR3	2.64e-06	2	57	2	10617617
Pubmed	S1P2 receptor promotes mouse skeletal muscle regeneration.	S1PR2 S1PR3	2.64e-06	2	57	2	22744969
Pubmed	The role of sphingosine 1-phosphate receptors on retinal pigment epithelial cells barrier function and angiogenic effects.	S1PR2 S1PR3	2.64e-06	2	57	2	31415870
Pubmed	Prostacyclin induction by high-density lipoprotein (HDL) in vascular smooth muscle cells depends on sphingosine 1-phosphate receptors: effect of simvastatin.	S1PR2 S1PR3	2.64e-06	2	57	2	18612546
Pubmed	Differential expression of S1P receptor subtypes in human bladder transitional cell carcinoma.	S1PR2 S1PR3	7.91e-06	3	57	2	30712233
Pubmed	Role of sphingosine kinase and sphingosine-1-phosphate receptor in the liver pathology of mice infected with Plasmodium berghei ANKA.	S1PR2 S1PR3	7.91e-06	3	57	2	35333897
Pubmed	Differential expression of sphingosine-1-phosphate receptors in abdominal aortic aneurysms.	S1PR2 S1PR3	7.91e-06	3	57	2	22547907
Pubmed	Tripartite motif containing protein 27 negatively regulates CD4 T cells by ubiquitinating and inhibiting the class II PI3K-C2β.	PIK3C2A PIK3C2B	7.91e-06	3	57	2	22128329
Pubmed	[Regulation of Rho family G proteins and cell motility by the Edg family of sphingosin 1-phosphate receptors].	S1PR2 S1PR3	7.91e-06	3	57	2	11915348
Pubmed	S1P1 receptor localization confers selectivity for Gi-mediated cAMP and contractile responses.	S1PR2 S1PR3	7.91e-06	3	57	2	18296752
Pubmed	DNA-damage-induced type I interferon promotes senescence and inhibits stem cell function.	WRN IFNAR1	7.91e-06	3	57	2	25921537
Pubmed	Class II phosphoinositide 3-kinases contribute to endothelial cells morphogenesis.	PIK3C2A PIK3C2B	7.91e-06	3	57	2	23320105
Pubmed	Differential effects of sphingosine 1-phosphate receptors on airway and vascular barrier function in the murine lung.	S1PR2 S1PR3	7.91e-06	3	57	2	19749179
Pubmed	Sphingosine 1-phosphate (S1P)/S1P receptors are involved in human liver fibrosis by action on hepatic myofibroblasts motility.	S1PR2 S1PR3	7.91e-06	3	57	2	21145832
Pubmed	The molecular mechanisms mediating class II PI 3-kinase function in cell physiology.	PIK3C2A PIK3C2B	7.91e-06	3	57	2	33387369
Pubmed	Sphingosine 1-phosphate and human ether-a'-go-go-related gene potassium channels modulate migration in human anaplastic thyroid cancer cells.	S1PR2 S1PR3	7.91e-06	3	57	2	22889737
Pubmed	The class II PI 3-kinase, PI3KC2α, links platelet internal membrane structure to shear-dependent adhesive function.	PIK3C2A PIK3C2B	7.91e-06	3	57	2	25779105
Pubmed	Differential pharmacological properties and signal transduction of the sphingosine 1-phosphate receptors EDG-1, EDG-3, and EDG-5.	S1PR2 S1PR3	7.91e-06	3	57	2	10383399
Pubmed	HIV-1 Tat protein down-regulates CREB transcription factor expression in PC12 neuronal cells through a phosphatidylinositol 3-kinase/AKT/cyclic nucleoside phosphodiesterase pathway.	PDE2A PIK3C2A PIK3C2B	1.19e-05	27	57	3	11156964
Pubmed	Endothelial sphingosine 1-phosphate receptors promote vascular normalization and antitumor therapy.	S1PR2 S1PR3	1.58e-05	4	57	2	31988136
Pubmed	Sphingosine 1-phosphate stimulates proliferation and migration of satellite cells: role of S1P receptors.	S1PR2 S1PR3	1.58e-05	4	57	2	22178384
Pubmed	Interaction of integrin β4 with S1P receptors in S1P- and HGF-induced endothelial barrier enhancement.	S1PR2 S1PR3	1.58e-05	4	57	2	24851274
Pubmed	Sphingosine 1-phosphate: a ligand for the EDG-1 family of G-protein-coupled receptors.	S1PR2 S1PR3	1.58e-05	4	57	2	10818441
Pubmed	Regulation of mammalian autophagy by class II and III PI 3-kinases through PI3P synthesis.	PIK3C2A PIK3C2B	1.58e-05	4	57	2	24098492
Pubmed	Sphingosine-1-phosphate receptor expression and signaling correlate with uterine prostaglandin-endoperoxide synthase 2 expression and angiogenesis during early pregnancy.	S1PR2 S1PR3	1.58e-05	4	57	2	16319286
Pubmed	Marked perinatal lethality and cellular signaling deficits in mice null for the two sphingosine 1-phosphate (S1P) receptors, S1P(2)/LP(B2)/EDG-5 and S1P(3)/LP(B3)/EDG-3.	S1PR2 S1PR3	1.58e-05	4	57	2	12006579
Pubmed	Comparative analysis of three murine G-protein coupled receptors activated by sphingosine-1-phosphate.	S1PR2 S1PR3	1.58e-05	4	57	2	9931453
Pubmed	Sphingosine-1-phosphate and its potentially paradoxical effects on critical parameters of cutaneous wound healing.	S1PR2 S1PR3	1.58e-05	4	57	2	12648236
Pubmed	Specific and overlapping sphingosine-1-phosphate receptor functions in human synoviocytes: impact of TNF-alpha.	S1PR2 S1PR3	1.58e-05	4	57	2	18658144
Pubmed	Class II PI3Ks α and β Are Required for Rho-Dependent Uterine Smooth Muscle Contraction and Parturition in Mice.	PIK3C2A PIK3C2B	1.58e-05	4	57	2	30476019
Pubmed	Platelet and Erythrocyte Sources of S1P Are Redundant for Vascular Development and Homeostasis, but Both Rendered Essential After Plasma S1P Depletion in Anaphylactic Shock.	S1PR2 S1PR3	2.63e-05	5	57	2	27582371
Pubmed	Intracellular role for sphingosine kinase 1 in intestinal adenoma cell proliferation.	S1PR2 S1PR3	2.63e-05	5	57	2	16980623
Pubmed	Sphingosine-1-phosphate receptor 2.	S1PR2 S1PR3	2.63e-05	5	57	2	23879641
Pubmed	The G protein-coupled receptor P2RY8 and follicular dendritic cells promote germinal center confinement of B cells, whereas S1PR3 can contribute to their dissemination.	S1PR2 S1PR3	2.63e-05	5	57	2	26573295
Pubmed	Sphingosine 1-phosphate receptors negatively regulate collagen type I/III expression in human bone marrow-derived mesenchymal stem cell.	S1PR2 S1PR3	2.63e-05	5	57	2	24038457
Pubmed	Sphingosine 1-Phoshpate Receptors are Located in Synapses and Control Spontaneous Activity of Mouse Neurons in Culture.	S1PR2 S1PR3	2.63e-05	5	57	2	35781853
Pubmed	Class II phosphoinositide 3-kinases are downstream targets of activated polypeptide growth factor receptors.	PIK3C2A PIK3C2B	2.63e-05	5	57	2	10805725
Pubmed	Sphingosine kinase 1/S1P receptor signaling axis controls glial proliferation in mice with Sandhoff disease.	S1PR2 S1PR3	2.63e-05	5	57	2	18424450
Pubmed	The sphingosine-1-phosphate receptors S1P1, S1P2, and S1P3 function coordinately during embryonic angiogenesis.	S1PR2 S1PR3	2.63e-05	5	57	2	15138255
Pubmed	Pooled analysis of phosphatidylinositol 3-kinase pathway variants and risk of prostate cancer.	PIK3C2A PIK3C2B	2.63e-05	5	57	2	20197460
Pubmed	Differential coupling of the sphingosine 1-phosphate receptors Edg-1, Edg-3, and H218/Edg-5 to the G(i), G(q), and G(12) families of heterotrimeric G proteins.	S1PR2 S1PR3	3.94e-05	6	57	2	10488065
Pubmed	Selective loss of sphingosine 1-phosphate signaling with no obvious phenotypic abnormality in mice lacking its G protein-coupled receptor, LP(B3)/EDG-3.	S1PR2 S1PR3	3.94e-05	6	57	2	11443127
Pubmed	ER stress stimulates production of the key antimicrobial peptide, cathelicidin, by forming a previously unidentified intracellular S1P signaling complex.	S1PR2 S1PR3	3.94e-05	6	57	2	26903652
Pubmed	Human ltk receptor tyrosine kinase binds to PLC-gamma 1, PI3-K, GAP and Raf-1 in vivo.	RASA1 PIK3C2B	3.94e-05	6	57	2	8084603
Pubmed	The role of sphingosine kinase isoforms and receptors S1P1, S1P2, S1P3, and S1P5 in primary, secondary, and recurrent glioblastomas.	S1PR2 S1PR3	3.94e-05	6	57	2	24903384
Pubmed	Differential expression of sphingosine-1-phosphate receptors 1-5 in the developing nervous system.	S1PR2 S1PR3	5.51e-05	7	57	2	19161225
Pubmed	Essential role for sphingosine kinases in neural and vascular development.	S1PR2 S1PR3	5.51e-05	7	57	2	16314531
Pubmed	Regulation of ABCA1-mediated cholesterol efflux by sphingosine-1-phosphate signaling in macrophages.	S1PR2 S1PR3	5.51e-05	7	57	2	30655318
Pubmed	Sphingosine kinase 1 and sphingosine-1-phosphate receptor 2 are vital to recovery from anaphylactic shock in mice.	S1PR2 S1PR3	5.51e-05	7	57	2	20407207
Pubmed	The Sphingosine-1-phospate receptor 1 mediates S1P action during cardiac development.	S1PR2 S1PR3	5.51e-05	7	57	2	21668976
Pubmed	Chemerin, a novel adipokine in the regulation of angiogenesis.	OR10J3 OR10J1	7.34e-05	8	57	2	20237162
Pubmed	The HIV-1 nef protein interferes with phosphatidylinositol 3-kinase activation 1.	PIK3C2A PIK3C2B	1.18e-04	10	57	2	8636073
Pubmed	Embryonic brain expression analysis of lysophospholipid receptor genes suggests roles for s1p(1) in neurogenesis and s1p(1-3) in angiogenesis.	S1PR2 S1PR3	1.18e-04	10	57	2	12401212
Pubmed	Extracellular human immunodeficiency virus type-1 Tat protein activates phosphatidylinositol 3-kinase in PC12 neuronal cells.	PIK3C2A PIK3C2B	1.18e-04	10	57	2	8798481
Pubmed	Sphingosine-1-phosphate inhibits cell migration and endothelial to mesenchymal cell transformation during cardiac development.	S1PR2 S1PR3	1.18e-04	10	57	2	16434032
Pubmed	Expression of HIV-1 nef decreases basal phosphatidyl-inositol 3-kinase activity.	PIK3C2A PIK3C2B	1.18e-04	10	57	2	9247029
Pubmed	Vascular function and sphingosine-1-phosphate regulate development of the dorsal pancreatic mesenchyme.	S1PR2 S1PR3	1.18e-04	10	57	2	15689381
Pubmed	HIV-1 gp120-induced TNF-{alpha} production by primary human macrophages is mediated by phosphatidylinositol-3 (PI-3) kinase and mitogen-activated protein (MAP) kinase pathways.	PIK3C2A PIK3C2B	1.44e-04	11	57	2	16081599
Pubmed	Dynamic regulation of sphingosine-1-phosphate homeostasis during development of mouse metanephric kidney.	S1PR2 S1PR3	1.44e-04	11	57	2	19073640
Pubmed	HIV-1 Tat induces tyrosine phosphorylation of p125FAK and its association with phosphoinositide 3-kinase in PC12 cells.	PIK3C2A PIK3C2B	1.44e-04	11	57	2	9708406
Pubmed	Developmental basis for filamin-A-associated myxomatous mitral valve disease.	FLNA TPH1	1.44e-04	11	57	2	22843703
Pubmed	HIV-Nef enhances interleukin-2 production and phosphatidylinositol 3-kinase activity in a human T cell line.	PIK3C2A PIK3C2B	1.44e-04	11	57	2	10985305
Pubmed	Nef-mediated disruption of HLA-A2 transport to the cell surface in T cells.	PIK3C2A PIK3C2B	1.44e-04	11	57	2	12584329
Pubmed	Ligands of CD4 inhibit the association of phospholipase Cgamma1 with phosphoinositide 3 kinase in T cells: regulation of this association by the phosphoinositide 3 kinase activity.	PIK3C2A PIK3C2B	1.44e-04	11	57	2	9808187
Pubmed	Stimulatory actions of lysophosphatidic acid on mouse ATDC5 chondroprogenitor cells.	S1PR2 S1PR3	1.44e-04	11	57	2	20458606
Pubmed	Human immunodeficiency virus type 1 tat-mediated cytotoxicity of human brain microvascular endothelial cells.	PIK3C2A PIK3C2B	1.72e-04	12	57	2	14602571
Pubmed	Colony-stimulating factor-1 requires PI3-kinase-mediated metabolism for proliferation and survival in myeloid cells.	PIK3C2A PIK3C2B	1.72e-04	12	57	2	16514418
Pubmed	TLR9-independent CD8+ T cell responses in hepatic AAV gene transfer through IL-1R1-MyD88 signaling.	F8 IFNAR1	1.72e-04	12	57	2	38053332
Pubmed	HIV-1 Nef plays an essential role in two independent processes in CD4 down-regulation: dissociation of the CD4-p56(lck) complex and targeting of CD4 to lysosomes.	PIK3C2A PIK3C2B	1.72e-04	12	57	2	10208934
Pubmed	Recruitment of phosphatidylinositol 3-kinase to CD28 inhibits HIV transcription by a Tat-dependent mechanism.	PIK3C2A PIK3C2B	1.72e-04	12	57	2	12077252
Pubmed	Down-regulation of LFA-1-mediated T cell adhesion induced by the HIV envelope glycoprotein gp160 requires phosphatidylinositol-3-kinase activity.	PIK3C2A PIK3C2B	1.72e-04	12	57	2	9341793
Pubmed	Phosphatidylinositol 3-kinase regulates human immunodeficiency virus type 1 replication following viral entry in primary CD4+ T lymphocytes and macrophages.	PIK3C2A PIK3C2B	1.72e-04	12	57	2	12551992
Pubmed	HIV-1 Nef in macrophage-mediated disease pathogenesis.	PIK3C2A PIK3C2B	2.03e-04	13	57	2	23215766
Pubmed	Extracellular HIV-1 Tat protein activates phosphatidylinositol 3- and Akt/PKB kinases in CD4+ T lymphoblastoid Jurkat cells.	PIK3C2A PIK3C2B	2.03e-04	13	57	2	9394803
Pubmed	Expression patterns of the lysophospholipid receptor genes during mouse early development.	S1PR2 S1PR3	2.03e-04	13	57	2	18924241
Pubmed	Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening.	FLNA PIK3C2B TRAIP THOC2 ASAP1	2.06e-04	329	57	5	17474147
Pubmed	Infection of human immunodeficiency virus and intracellular viral Tat protein exert a pro-survival effect in a human microglial cell line.	PIK3C2A PIK3C2B	2.37e-04	14	57	2	17157319
Pubmed	HIV Nef enhances Tat-mediated viral transcription through a hnRNP-K-nucleated signaling complex.	PIK3C2A PIK3C2B	2.73e-04	15	57	2	18854243
Pubmed	Lysophospholipid receptor nomenclature review: IUPHAR Review 8.	S1PR2 S1PR3	2.73e-04	15	57	2	24602016
Pubmed	HIV-1 gp120-mediated apoptosis of T cells is regulated by the membrane tyrosine phosphatase CD45.	PIK3C2A PIK3C2B	3.12e-04	16	57	2	16524887
Pubmed	HIV-1 Nef blocks transport of MHC class I molecules to the cell surface via a PI 3-kinase-dependent pathway.	PIK3C2A PIK3C2B	3.12e-04	16	57	2	11289809
Pubmed	Human immunodeficiency virus type 1 Tat accelerates Kaposi sarcoma-associated herpesvirus Kaposin A-mediated tumorigenesis of transformed fibroblasts in vitro as well as in nude and immunocompetent mice.	PIK3C2A PIK3C2B	3.12e-04	16	57	2	20019835
Pubmed	Akt/Nox2/NF-κB signaling pathway is involved in Tat-induced HIV-1 long terminal repeat (LTR) transactivation.	PIK3C2A PIK3C2B	3.12e-04	16	57	2	21029719
Pubmed	Erythropoietin plus insulin-like growth factor-I protects against neuronal damage in a murine model of human immunodeficiency virus-associated neurocognitive disorders.	PIK3C2A PIK3C2B	3.12e-04	16	57	2	20818790
Pubmed	LRRC31 inhibits DNA repair and sensitizes breast cancer brain metastasis to radiation therapy.	FLNA RRP12 TUT7 WRN	3.43e-04	202	57	4	33005030
Pubmed	DNA sequence and analysis of human chromosome 9.	ZNF658 ARRDC1 TUT7 S1PR3 GPR107	3.53e-04	370	57	5	15164053
Cytoband	1q23.2	OR10J3 OR10J1	8.78e-04	35	57	2	1q23.2
Cytoband	4p14	TLR10 WDR19	1.26e-03	42	57	2	4p14
Cytoband	8p12	WRN MBOAT4	1.58e-03	47	57	2	8p12
Cytoband	Ensembl 112 genes in cytogenetic band chr4p14	TLR10 WDR19	3.18e-03	67	57	2	chr4p14
Cytoband	Ensembl 112 genes in cytogenetic band chr8p12	WRN MBOAT4	3.66e-03	72	57	2	chr8p12
GeneFamily	Sphingosine 1-phosphate receptors\|CD molecules	S1PR2 S1PR3	3.63e-05	5	35	2	206
GeneFamily	Phosphatidylinositol 3-kinase subunits	PIK3C2A PIK3C2B	1.01e-04	8	35	2	831
GeneFamily	Immunoglobulin like domain containing	MALT1 ADGRA2 FCMR	6.10e-03	193	35	3	594
GeneFamily	Olfactory receptors, family 10	OR10J3 OR10J1	7.23e-03	66	35	2	157
GeneFamily	Ring finger proteins	TRAIP MKRN2 RNF213	1.59e-02	275	35	3	58
Coexpression	GSE22033_UNTREATED_VS_ROSIGLITAZONE_TREATED_MEF_DN	WDR19 MALT1 PIK3C2B RRP12 ASAP1 GPR107	4.67e-06	199	57	6	M7690
Coexpression	GSE32901_NAIVE_VS_TH17_ENRICHED_CD4_TCELL_UP	PLA2R1 PDE2A NSG2 TUT7 TBC1D23	2.15e-05	154	57	5	M8927
ToppCell	droplet-Thymus-nan-3m-Myeloid-B_cell\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MALT1 PIK3C2B RASSF4 S1PR3 CALHM2 FCMR	7.15e-08	166	57	6	c0af93db981dfd448abc7efcd257f3e5ff066aae
ToppCell	droplet-Liver-LIVER_HEP-30m-Endothelial\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PLA2R1 PDE2A PIK3C2B ADGRA2 F8	4.82e-06	193	57	5	826b8dd801298b3e0cd76232feae5a14026b8806
ToppCell	droplet-Liver-LIVER_HEP-30m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PLA2R1 PDE2A PIK3C2B ADGRA2 F8	4.82e-06	193	57	5	87d3a577d37fb0cb4b6313c596310de452bc3872
ToppCell	droplet-Liver-LIVER_HEP-30m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PLA2R1 PDE2A PIK3C2B ADGRA2 F8	4.82e-06	193	57	5	d485634c564b268e344b6a2863c26f6adaec9e38
ToppCell	3'-Broncho-tracheal-Immune_Lymphocytic-Lymphocytic_T/NK-CD4-positive,_alpha-beta_T_cell-CD4_T_cells\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	PPP2R5C RNF213 GPR171 UBASH3A FCMR	4.94e-06	194	57	5	906fe1689906d1498acf6fd26a215c7e5a854a38
ToppCell	3'-Broncho-tracheal-Immune_Lymphocytic-Lymphocytic_T/NK-CD4-positive,_alpha-beta_T_cell-CD4_T_cells-CD4_T_cells_L.1.1.1.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	PPP2R5C RNF213 GPR171 UBASH3A FCMR	4.94e-06	194	57	5	af7428582b96a500f255c45efc02b6c10c4740d9
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	PDE2A PIK3C2A PIK3C2B F8 ASAP1	4.94e-06	194	57	5	74a9fdb73f279bebb6337510deab9aaaf9f7e957
ToppCell	3'-Broncho-tracheal-Immune_Lymphocytic-Lymphocytic_T/NK-CD4-positive,_alpha-beta_T_cell\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	PPP2R5C RNF213 GPR171 UBASH3A FCMR	4.94e-06	194	57	5	4138f3e8aa214504fca03962a43250670ae45215
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Endothelial-blood_vessel_endothelial_cell_of_kidney\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	PDE2A PIK3C2A PIK3C2B F8 ASAP1	5.19e-06	196	57	5	22767bcf0095d9eb0cbed7cdc74e4d32d9357e1b
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Endothelial\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	PDE2A PIK3C2A PIK3C2B F8 ASAP1	5.19e-06	196	57	5	adee900dcd16dbaba15c58bdcace09ba20214950
ToppCell	Control_saline-Mesenchymal_myocytic-Pericyte-Pericyte_3\|Control_saline / Treatment groups by lineage, cell group, cell type	FLNA CFAP221 DAAM2 S1PR3 CALHM2	5.73e-06	200	57	5	b0866b497aa71d06cef25f9a335fa584e95fa7e0
ToppCell	droplet-Lung-nan-18m-Lymphocytic-Zbtb32+_B\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MALT1 PIK3C2B MFSD12 FCMR	6.06e-05	166	57	4	3e3e9296e6919a38602e417a6606c046af3bd101
ToppCell	P15-Epithelial-airway_epithelial_cell-ciliated_cell_of_airway\|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	WDR19 PIK3C2B DAAM2 IQUB	6.20e-05	167	57	4	5c3d0763f73628c71c71f9883556bb4f1639f3cc
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Glomerular_Capillary_Endothelial_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	PDE2A PIK3C2A PIK3C2B F8	6.50e-05	169	57	4	987ff79ad563825dd9877ea8ccb536758f8c6700
ToppCell	droplet-Kidney-nan-18m-Epithelial-Pecam____kidney_capillary_endothelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PLA2R1 DAAM2 F8 S1PR3	6.50e-05	169	57	4	87116c33c5ca8cb1862e103e5607b1df4d264569
ToppCell	droplet-Lung-21m-Hematologic-lymphocytic-CD8-positive,_alpha-beta_T_cell-CD8-positive,_alpha-beta_T_cell_l48\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	MMS22L PDE2A FASTKD1 FCMR	6.65e-05	170	57	4	070d8683d1a5cc7d594ff0453c961a9bf982c2d0
ToppCell	droplet-Lung-30m-Hematologic-lymphocytic-CD8-positive,_alpha-beta_T_cell-CD8-positive,_alpha-beta_T_cell_l9\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	PDE2A NSG2 GPR171 UBASH3A	6.65e-05	170	57	4	8e9b5f7bfb61f8d84d0b17fb0c191da4dabad63d
ToppCell	Control-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_3\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	CFAP221 DAAM2 S1PR3 CALHM2	6.80e-05	171	57	4	4ede831aed364cb5271f49a8b09bb6d0452f9b35
ToppCell	facs-Lung-nan-3m-Lymphocytic-B_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MALT1 PIK3C2B GPR171 FCMR	6.80e-05	171	57	4	a31c23406cf6d6a17358a8fb41d392a7fb0306e0
ToppCell	facs-Lung-nan-3m-Lymphocytic-B_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MALT1 PIK3C2B GPR171 FCMR	6.80e-05	171	57	4	43d8fd9b9546e84a652564fe96b514b34b06262b
ToppCell	droplet-Fat-Mat-18m-Lymphocytic-lymphocyte\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NSG2 HERC3 GPR171 FCMR	6.96e-05	172	57	4	226de1a5d4a360d3ae01b0235fea19521ec623a0
ToppCell	COVID-19-kidney-REN+Pericyte\|COVID-19 / Disease (COVID-19 only), tissue and cell type	HIP1 DAAM2 ADGRA2 S1PR3	7.27e-05	174	57	4	8393f0b43c767839c1630bcb952d62b42efc788d
ToppCell	10x_3'_v2v3-Non-neoplastic-Lymphoid-CD4/CD8-CD8_cytotoxic-D\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	PPP2R5C FASTKD1 GPR171 UBASH3A	7.44e-05	175	57	4	a3f8c54c77bce9b035a4835945ab341909be4946
ToppCell	droplet-Lung-30m-Hematologic-lymphocytic-CD8-positive,_alpha-beta_T_cell\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	PDE2A NSG2 GPR171 UBASH3A	7.44e-05	175	57	4	f949613ee45f5d950578c512d197716855118d18
ToppCell	droplet-Liver-LIVER_HEP-30m-Myeloid-Kupffer_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	WDR19 EQTN WDFY3 RASSF4	7.60e-05	176	57	4	5e46a09a36b9645b1b1fcb0b64bd0898561af3a9
ToppCell	droplet-Liver-LIVER_HEP-30m-Myeloid-Kupffer_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	WDR19 EQTN WDFY3 RASSF4	7.77e-05	177	57	4	14fb8d182775dfd0e49aa7e4e12543a85b3b8bd6
ToppCell	facs-Spleen-nan-3m-Lymphocytic-CD8-positive,_alpha-beta_T_cell\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PDE2A NSG2 UBASH3A TPH1	7.77e-05	177	57	4	ac0cf03e2a1baf84db3ae245d59bbc6ae52c13be
ToppCell	facs-Lung-18m-Hematologic-lymphocytic-CD8-positive,_alpha-beta_T_cell-CD8-positive,_alpha-beta_T_cell_l9\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	PDE2A NSG2 GPR171 UBASH3A	7.77e-05	177	57	4	d6b7d387e7485ff52ce27f51df8b8050f49fd941
ToppCell	5'-GW_trimst-2-LymphNode-Hematopoietic-T_cells-TRDV2/TRGV9_gdT\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PPP2R5C GPR171 UBASH3A FCMR	8.12e-05	179	57	4	f7d3d37505893ae55065c89d957084602729decc
ToppCell	10x3'2.3-week_14-16-Lymphocytic_T-T_NK-CD8_T_cell\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	RNF213 GPR171 UBASH3A FCMR	8.12e-05	179	57	4	4e9e0deabf9b09ffcf30fed6d5eae72ce0ef2f1f
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell_\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	PDE2A PIK3C2B F8 ASAP1	8.12e-05	179	57	4	8f9e538c822940785130297712b75131812a4603
ToppCell	10x5'-lymph-node_spleen-Myeloid_Mac-Intestinal_macrophages\|lymph-node_spleen / Manually curated celltypes from each tissue	INTU DAAM2 WDFY3 RASSF4	8.29e-05	180	57	4	7be7d7a6906fff6dbdecd9cb013d855aba4eda2a
ToppCell	facs-Liver-Non-hepatocytes-3m-Lymphocytic-T_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MMS22L NSG2 TRAIP HERC3	8.29e-05	180	57	4	87347af8f28cf7c486c19f3f98c0afb022c323b5
ToppCell	droplet-Liver-hepatocytes-3m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PDE2A DAAM2 F8 ASAP1	8.47e-05	181	57	4	4df7972f88117108698efd06b124b232f8588981
ToppCell	RA-07._Pericyte\|RA / Chamber and Cluster_Paper	HIP1 DAAM2 ADGRA2 ASAP1	8.47e-05	181	57	4	8dfb42d096db6c2df9b41303a7199d134d4bff07
ToppCell	droplet-Liver-hepatocytes-3m-Endothelial\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PDE2A DAAM2 F8 ASAP1	8.47e-05	181	57	4	cbb530566893281289026bfd93adf721decd4ca3
ToppCell	RA-07._Pericyte\|World / Chamber and Cluster_Paper	HIP1 DAAM2 ADGRA2 ASAP1	8.66e-05	182	57	4	2075efeae633550fb2eb026d0dfd741c8252482e
ToppCell	RA-17._Lymphocyte\|RA / Chamber and Cluster_Paper	PPP2R5C GPR171 UBASH3A FCMR	8.66e-05	182	57	4	257a7847917b6ea1d60608183d90300bfd028758
ToppCell	Cerebellum-Endothelial-MURAL-M1(Rgs5Acta2)\|Cerebellum / BrainAtlas - Mouse McCarroll V32	FLNA PLA2R1 S1PR3 CALHM2	8.66e-05	182	57	4	da61e7cb2537c567968d8bd8baf537ecdff0ab18
ToppCell	Cerebellum-Endothelial-MURAL\|Cerebellum / BrainAtlas - Mouse McCarroll V32	FLNA PLA2R1 S1PR3 CALHM2	8.66e-05	182	57	4	b2f03f61aebb5920595fed8b9d6799a09353419b
ToppCell	5'-Parenchyma_lung-Endothelial-Lymphatic_EC-endothelial_cell_of_lymphatic_vessel-Lymphatic_EC_differentiating-Lymphatic_EC_differentiating_L.2.5.1.1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	PDE2A ADGRA2 F8 ASAP1	8.84e-05	183	57	4	4d16bfbadf2cd13008c35e23dd2b5b4ecf92ee11
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Mesenchymal-Myocytic_interstitial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	FLNA DAAM2 ADGRA2 ASAP1	8.84e-05	183	57	4	667717366cb181b8a04a347e64f0f5a4dfc6ee7f
ToppCell	facs-Limb_Muscle-ForelimbandHindlimb-3m-Lymphocytic\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MALT1 NSG2 GPR171 FCMR	9.03e-05	184	57	4	5cf7447faaec99fc37dfa8e92ff72cc2c7c05951
ToppCell	facs-Limb_Muscle-ForelimbandHindlimb-3m-Lymphocytic-nan\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MALT1 NSG2 GPR171 FCMR	9.03e-05	184	57	4	7126261a453c7e2f3f005016873b6adeb51e46f8
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	HIP1 DAAM2 ADGRA2 ASAP1	9.22e-05	185	57	4	7092436b4db90289516ed130ade596e3021cffaf
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	FLNA HIP1 DAAM2 ADGRA2	9.22e-05	185	57	4	51dfe6ac7df8b330343b37e3bee71e5c65267189
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte-\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	HIP1 DAAM2 ADGRA2 ASAP1	9.22e-05	185	57	4	a8ca7819066d5297ef6966e7f3e2c9f8a7673fdc
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	FLNA HIP1 DAAM2 ADGRA2	9.22e-05	185	57	4	a8c02cec3c414f3a0da9f2d6d28ce563b0030705
ToppCell	wk_20-22-Hematologic_Lymphocytic-T_&_ILC-NKT2\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	PPP2R5C RNF213 UBASH3A FCMR	9.22e-05	185	57	4	2d95713deaa05fb3372f4337ef156027e4d8ec8a
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Immune-Lymphocytic_T/NK\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	PPP2R5C GPR171 UBASH3A FCMR	9.41e-05	186	57	4	9d576dce2c5deefef1adda16c6da7055c8d57f8f
ToppCell	5'-Parenchyma_lung-Endothelial-Lymphatic_EC-endothelial_cell_of_lymphatic_vessel-Lymphatic_EC_differentiating\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	PDE2A ADGRA2 F8 ASAP1	9.41e-05	186	57	4	40070d9cd20188ba49b32acfca9bc16256b38bf5
ToppCell	kidney_cells-Adult_normal_reference-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell-mesangial_typical\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PLA2R1 DAAM2 S1PR3 TPH1	9.61e-05	187	57	4	d591a3c216997663ab77710fed0d230ffc37e41a
ToppCell	kidney_cells-Adult_normal_reference-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PLA2R1 DAAM2 S1PR3 TPH1	9.61e-05	187	57	4	d1dc8c9a2c2cd10c640257161a75e7730ec5bb41
ToppCell	kidney_cells-Adult_normal_reference-Mesenchymal-glomerular_mesenchymal_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PLA2R1 DAAM2 S1PR3 TPH1	9.61e-05	187	57	4	ac8e092b37e042975e2ee057d3f7c6821e58e8b5
ToppCell	facs-BAT-Fat-3m-Lymphocytic-B_cell\|BAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MALT1 PIK3C2B GPR171 FCMR	9.61e-05	187	57	4	63cc89ce24d3f8fb13479a501a20bfbd798d151a
ToppCell	droplet-Lung-30m-Hematologic-lymphocytic\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	NSG2 GPR171 UBASH3A FCMR	9.61e-05	187	57	4	66cf67c76067e4ba8c09c110adfa0ccc0d1c5ee9
ToppCell	facs-Lung-3m-Hematologic-lymphocytic\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	NSG2 GPR171 UBASH3A FCMR	9.81e-05	188	57	4	2ab75632860934f067a47be5af18bb3ad630bb68
ToppCell	Children_(3_yrs)-Immune-T_lymphocyte-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	PPP2R5C GPR171 UBASH3A FCMR	1.00e-04	189	57	4	df30478b288084a1bd48f660409dcc784040897c
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Immune-Lymphocytic_T/NK-T_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PPP2R5C GPR171 UBASH3A FCMR	1.00e-04	189	57	4	b87d586a9570fa54f3e0c6bd4731c5badcaedae6
ToppCell	facs-Lung-EPCAM-18m-Lymphocytic\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NSG2 GPR171 UBASH3A FCMR	1.00e-04	189	57	4	224d8304cc87b8573a4a78cf88a49d41564f7a47
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Immune-Lymphocytic_T/NK\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PPP2R5C GPR171 UBASH3A FCMR	1.00e-04	189	57	4	823d6debd09e440ddf36c54af24a5f20e222a21e
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Immune-Lymphocytic_T/NK-T_Cell-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PPP2R5C GPR171 UBASH3A FCMR	1.00e-04	189	57	4	47c2b419b081d5bf75da5e3d9a0e05a70362dfe7
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Ascending_Vasa_Recta_Endothelial_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	PDE2A PIK3C2A PIK3C2B ASAP1	1.02e-04	190	57	4	656483751e4bf137e4e4bfb2a03a478a8f7fcb63
ToppCell	NS-critical-d_0-4-Lymphoid\|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	PPP2R5C GPR171 UBASH3A FCMR	1.02e-04	190	57	4	84f9f5ac29ff0f929a589b76efa61d4c570e76b0
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Immune-Lymphocytic_T/NK\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PPP2R5C GPR171 UBASH3A FCMR	1.02e-04	190	57	4	b772a5d281fe016f259ddda80d6f33d949dcac2b
ToppCell	PBMC-Severe-Myeloid-Neutrophil-Neutrophil-Neu_4\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	MMS22L FASTKD1 WRN HERC3	1.02e-04	190	57	4	3f0c7d130f66faea778fe567604edf1b4cdf85b3
ToppCell	facs-MAT-Fat-3m-Lymphocytic-nan\|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MALT1 NSG2 GPR171 FCMR	1.04e-04	191	57	4	530469909ab0994bece37945e9098359077b0824
ToppCell	COVID-19-kidney-vSMC/Pericyte\|kidney / Disease (COVID-19 only), tissue and cell type	FLNA DAAM2 ADGRA2 S1PR3	1.04e-04	191	57	4	fad8eaa536001b911d05ae2b12150c2398cc6f88
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Immune-Lymphocytic_T/NK-T_Cell-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PPP2R5C GPR171 UBASH3A FCMR	1.04e-04	191	57	4	1a2d5fec2bea96da2154b0aed252f1bb35102f6e
ToppCell	COVID-19-lung-CD8+_T_cells\|COVID-19 / Disease (COVID-19 only), tissue and cell type	PPP2R5C GPR171 UBASH3A FCMR	1.04e-04	191	57	4	543f8ae07cc2e6950c888115a5ca9445e3c0f618
ToppCell	facs-MAT-Fat-3m-Lymphocytic\|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MALT1 NSG2 GPR171 FCMR	1.04e-04	191	57	4	f7a81acb938ce5d383326840dd45f7dd2cf12b1d
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	DAAM2 ADGRA2 S1PR3 ASAP1	1.04e-04	191	57	4	7b0d42a877540dbb346a76a62403e0d5d3e07fa6
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Immune-Lymphocytic_T/NK-T_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PPP2R5C GPR171 UBASH3A FCMR	1.04e-04	191	57	4	326b4541069efedc8ab409f85bb11f77346dda90
ToppCell	RA-09._Endothelium_I\|World / Chamber and Cluster_Paper	PIK3C2A PIK3C2B F8 ASAP1	1.04e-04	191	57	4	c8a0c2af119bc34a8f694a7d30642f28002c84b9
ToppCell	COVID-19-T_cells-CD4+_T_cells\|COVID-19 / group, cell type (main and fine annotations)	PPP2R5C GPR171 UBASH3A FCMR	1.04e-04	191	57	4	0646cca78e24aeb6baa9934d3c439b797c567997
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Lymphoid-CD4/CD8-CD8_EM-C\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	GPR171 UBASH3A MBOAT4 FCMR	1.04e-04	191	57	4	d5086ffdba3635e649ad2ab9628634ddb1df7fdc
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	DAAM2 ADGRA2 S1PR3 ASAP1	1.04e-04	191	57	4	cd854b9c426924fdc84bf7f411f6dea447143e79
ToppCell	NS-moderate-d_16-33-Lymphoid-Treg\|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	PPP2R5C GPR171 UBASH3A FCMR	1.06e-04	192	57	4	48d557071bad80edd3ec6e5ad8dcd97037da9553
ToppCell	COVID-19-kidney-AQP1+PLVAP+EC\|COVID-19 / Disease (COVID-19 only), tissue and cell type	PDE2A PIK3C2B F8 ASAP1	1.06e-04	192	57	4	27ff3621e177e7932dd44dd6baa81551ea75a874
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	FLNA HIP1 DAAM2 ADGRA2	1.06e-04	192	57	4	bfab13793e54de2550ee171397f7ece0625cdb4a
ToppCell	moderate-Lymphoid-Treg\|moderate / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	PPP2R5C GPR171 UBASH3A FCMR	1.06e-04	192	57	4	e370ff5aaff7b7042ba9aaf93de43aa563b8b9f9
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	FLNA HIP1 DAAM2 ADGRA2	1.06e-04	192	57	4	b54b0d5b88139905521c8d5d58332e89c08d589c
ToppCell	Parenchymal-10x3prime_v2-Immune_Lymphocytic-T-T_CD4-T_reg\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	GPR171 UBASH3A MFSD12 FCMR	1.06e-04	192	57	4	94e11f68767a899cbcc6984f9398877c1e464abc
ToppCell	droplet-Liver-HEPATOCYTES-1m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PDE2A PIK3C2B ADGRA2 F8	1.06e-04	192	57	4	5890076929598e88fe9d59a4e4e858b446746ce9
ToppCell	PBMC-Severe-Myeloid-Neutrophil-Neutrophil-Neu_4\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	MMS22L FASTKD1 WRN HERC3	1.06e-04	192	57	4	c09dcc73ff9c3855a0f3d7bfa0d5c99c09a117f2
ToppCell	droplet-Liver-HEPATOCYTES-1m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PDE2A PIK3C2B ADGRA2 F8	1.09e-04	193	57	4	4a8c97ff2dffc5c06351d1cb107e21e58250aa55
ToppCell	droplet-Liver-HEPATOCYTES-1m-Endothelial\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PDE2A PIK3C2B ADGRA2 F8	1.09e-04	193	57	4	d5f6d6e2c36d4e80af4d39cdfc0b18df295a587b
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Glomerular_Capillary_Endothelial_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	PDE2A PIK3C2B F8 ASAP1	1.09e-04	193	57	4	456aa8a8f1f9cbba0bd618a5f623909079c0f56b
ToppCell	COVID-19-kidney-T-cells-1\|COVID-19 / Disease (COVID-19 only), tissue and cell type	PPP2R5C GPR171 UBASH3A FCMR	1.09e-04	193	57	4	5b84fa640cf30dea55fde53b810f850ff946d253
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	PDE2A PIK3C2A PIK3C2B ASAP1	1.09e-04	193	57	4	287e756d5fd3bd2931c168da24beaa0d02a350ae
ToppCell	metastatic_Lymph_Node-T/NK_cells-CD4+_Th\|metastatic_Lymph_Node / Location, Cell class and cell subclass	PPP2R5C GPR171 UBASH3A CALHM2	1.11e-04	194	57	4	1ce9b4c1fbdbc5e39c03adf7ffba3d0efea81862
ToppCell	5'-Adult-LymphNode-Hematopoietic-T_cells-CD8_Tmem\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PPP2R5C GPR171 UBASH3A FCMR	1.11e-04	194	57	4	13c3674d601c8a7355ce869de1af6401938c0037
ToppCell	Children_(3_yrs)-Immune-T_lymphocyte-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	MALT1 PPP2R5C GPR171 UBASH3A	1.11e-04	194	57	4	3d6f2d190dd50804afea299957cc44c2bb756134
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	PDE2A PIK3C2B F8 ASAP1	1.11e-04	194	57	4	f76808666fb875fc787751cbfd924d9be20a8192
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Lymphoid-CD4/CD8-CD8_EM-G\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	RNF213 GPR171 UBASH3A FCMR	1.11e-04	194	57	4	c49f3341a19128855f084bcf18ef3da4bab79099
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	PDE2A PIK3C2B F8 ASAP1	1.11e-04	194	57	4	f5706ab6bc803606c4640ddd606617e4e797ccc9
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	PDE2A PIK3C2B F8 ASAP1	1.11e-04	194	57	4	a52c5906fce43c2f72cf7e463a3d15cde06431f6
ToppCell	(1)_T_CD8_CTL\|World / Spleen cell shreds - cell class (v1) and cell subclass (v1)	FLNA PPP2R5C RNF213 GPR171	1.13e-04	195	57	4	f582b854e5a4c52764aad5abe4e28ea77a7445f7
ToppCell	LA-09._Endothelium_I\|World / Chamber and Cluster_Paper	HIP1 PIK3C2A F8 ASAP1	1.13e-04	195	57	4	fc95457a298b5d0dab687d9ee7e225a7f7b9a0d4
ToppCell	10x3'2.3-week_14-16-Lymphocytic_T-T_NK\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	RNF213 GPR171 UBASH3A FCMR	1.13e-04	195	57	4	146e482f660c0f234a3d15495ad9e7ed7b88fdc8
Disease	lifestyle measurement, alcohol consumption measurement	INTU DAAM2 OR10J1 ASAP1	5.53e-05	115	53	4	EFO_0007878, EFO_0010724
Disease	rostral middle frontal gyrus volume measurement	PLA2R1 ARRDC1	2.84e-04	14	53	2	EFO_0010328
Disease	childhood trauma measurement, alcohol consumption measurement	PLA2R1 INTU HERC3	2.87e-04	71	53	3	EFO_0007878, EFO_0007979

Protein segments in the cluster

Peptide	Gene	Start	Entry
LHYLSPSREFKEYKC	EDDM3A	36	Q14507
YLIKPHSYVGLTCTA	ADGRA2	546	Q96PE1
KVKSLSVYHPQLAYC	PPP2R5C	256	Q13362
SKDHKCSLVFYILSP	ARRDC1	121	Q8N5I2
HDLANSKPSTICKYY	MKRN2	26	Q9H000
YSHVSCLLKGEKLLY	RASA1	256	P20936
KSELLGLLKTYNCYH	RASSF4	21	Q9H2L5
YSLYFHKCLGKELPS	GPR107	221	Q5VW38
ELIHKKLKYTEAYPC	DAAM2	361	Q86T65
HFYCDIIPLLKISYT	OR5H14	176	A6NHG9
SYLVSKDLPKHCLYT	MALT1	656	Q9UDY8
ETSYCLYPSHEKLLN	MMS22L	636	Q6ZRQ5
HTCYNLLDLPKYSSK	HERC3	1016	Q15034
TNLLYSYPKLRSCKS	FSIP2	631	Q5CZC0
LTKCLKHYCSPLSYR	CALHM2	201	Q9HA72
RHKIYKLSPETTYCL	IFNAR1	186	P17181
KYYLICSLSHNGKDL	PIK3C2A	706	O00443
SIYCGISIAHSLLYK	PDE2A	541	O00408
VYKHKRCIPASLDAY	NSG2	106	Q9Y328
SNLCFDPILYYHLSK	GPR171	276	O14626
LCLTYSYLSHVDLVK	F8	171	P00451
EKRYYCHSEVSSLPL	PIK3C2B	841	O00750
YKGYLICSHLPKDDL	INTU	521	Q9ULD6
YSCSYVPRKPVKHTA	FLNA	731	P21333
CVKASVLTPYYHKVD	FASTKD1	716	Q53R41
LHYCSMYSKPECLKL	ASAP1	641	Q9ULH1
SEHVCKALPYFSYLL	MBOAT4	156	Q96T53
KKIYFCHSCQLYLPS	IQUB	596	Q8NA54
CSATLYKLRHLSYKS	EQTN	201	Q9NQ60
LEACSTVLPLYAKHY	S1PR2	176	O95136
STILPLYSKKYIAFC	S1PR3	186	Q99500
YLTYSLHLPKKFIAT	MFSD12	301	Q6NUT3
HYSCASIAYLKPKSE	OR10J1	261	P30954
IHYGCASIIYLKPKS	OR10J3	251	Q5JRS4
TLIDYHLCSHPKYKF	CFAP221	676	Q4G0U5
TYETLKYISKTPCRH	CRCP	46	O75575
YCIPTRYHKLKALLE	TLR10	736	Q9BXR5
YASTKESYPHIKTVC	PLIN3	46	O60664
YDYTVKLLFKLHSCL	HIP1	236	O00291
YSRALKHFLKCPSSE	WDR19	1036	Q8NEZ3
LEKLYSYKPCDKISS	WRN	1106	Q14191
CESTLPYICKKYLNH	PLA2R1	346	Q13018
KLYSTIRPYLESKAH	RRP12	771	Q5JTH9
IVCISKKHLDKYIPY	RNF213	436	Q63HN8
VECPTCHKKFLSKYY	ZBTB48	291	P10074
LNKLYPTHACREYLK	TPH1	181	P17752
PCIKYTGHYFITTLL	TM2D2	141	Q9BX73
YYAASHKLIALAICK	THOC2	371	Q8NI27
TLRHCSKLFIYLYKV	WDFY3	761	Q8IZQ1
QYHEPELCSYLDTKK	TBC1D23	176	Q9NUY8
HAPSLKTSCEYVSLY	FCMR	356	O60667
AACLYYLSPLKLEHL	UBIAD1	146	Q9Y5Z9
YSHLISVGYCITKPK	ZNF658	41	Q5TYW1
KYVAPESTSSHCLLY	ZBED5	361	Q49AG3
CLRTTYKYFALPHKI	TUT7	621	Q5VYS8
SHYILQKYCSVKPCT	UBASH3A	216	P57075
YYEKLCLEKSHSPIQ	TRAIP	336	Q9BWF2