Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionmonoatomic anion transmembrane transporter activity

LRRC8E SLC17A3 MCOLN1 SLC5A6

1.53e-04151364GO:0008509
GeneOntologyMolecularFunctioniron ion transmembrane transporter activity

SLC11A2 MCOLN1

1.72e-0411362GO:0005381
GeneOntologyMolecularFunctiontransmembrane transporter activity

LRRC8E ABCB11 SLC11A2 SLC17A3 MCOLN1 MFSD1 SLC5A6 CHRNG KCNK1

1.88e-041180369GO:0022857
GeneOntologyMolecularFunctionsodium ion transmembrane transporter activity

SLC17A3 MCOLN1 SLC5A6 KCNK1

2.47e-04171364GO:0015081
GeneOntologyMolecularFunctiontransporter activity

LRRC8E ABCB11 SLC11A2 SLC17A3 MCOLN1 MFSD1 SLC5A6 CHRNG KCNK1

3.63e-041289369GO:0005215
GeneOntologyMolecularFunctionmonoatomic ion transmembrane transporter activity

LRRC8E SLC11A2 SLC17A3 MCOLN1 SLC5A6 CHRNG KCNK1

4.62e-04793367GO:0015075
GeneOntologyMolecularFunctionmonoatomic anion channel activity

LRRC8E SLC17A3 MCOLN1

8.41e-04103363GO:0005253
GeneOntologyMolecularFunctionmonoatomic cation transmembrane transporter activity

SLC11A2 SLC17A3 MCOLN1 SLC5A6 CHRNG KCNK1

1.10e-03664366GO:0008324
GeneOntologyMolecularFunctionsolute:monoatomic cation symporter activity

SLC11A2 SLC17A3 SLC5A6

1.28e-03119363GO:0015294
GeneOntologyMolecularFunctionmonoatomic ion channel activity

LRRC8E SLC17A3 MCOLN1 CHRNG KCNK1

1.31e-03459365GO:0005216
GeneOntologyMolecularFunctionmetal ion transmembrane transporter activity

SLC11A2 SLC17A3 MCOLN1 SLC5A6 KCNK1

1.39e-03465365GO:0046873
GeneOntologyMolecularFunctionactive transmembrane transporter activity

ABCB11 SLC11A2 SLC17A3 MFSD1 SLC5A6

1.56e-03477365GO:0022804
GeneOntologyMolecularFunctionxenobiotic transmembrane transporter activity

ABCB11 SLC17A3

1.71e-0334362GO:0042910
GeneOntologyMolecularFunctionsecondary active transmembrane transporter activity

SLC11A2 SLC17A3 MFSD1 SLC5A6

1.92e-03296364GO:0015291
GeneOntologyMolecularFunctionligand-gated monoatomic cation channel activity

MCOLN1 CHRNG KCNK1

2.03e-03140363GO:0099094
GeneOntologyMolecularFunctionchannel activity

LRRC8E SLC17A3 MCOLN1 CHRNG KCNK1

2.37e-03525365GO:0015267
GeneOntologyMolecularFunctiontransmembrane signaling receptor activity

MC5R GPR3 CD74 OR5M9 GPR101 TRHR AVPR1A CHRNG

2.39e-031353368GO:0004888
GeneOntologyMolecularFunctionpassive transmembrane transporter activity

LRRC8E SLC17A3 MCOLN1 CHRNG KCNK1

2.39e-03526365GO:0022803
GeneOntologyMolecularFunctionsymporter activity

SLC11A2 SLC17A3 SLC5A6

2.47e-03150363GO:0015293
GeneOntologyMolecularFunctionamide transmembrane transporter activity

MFSD1 SLC5A6

2.60e-0342362GO:0042887
GeneOntologyMolecularFunctiontransition metal ion transmembrane transporter activity

SLC11A2 MCOLN1

2.85e-0344362GO:0046915
GeneOntologyMolecularFunctiongated channel activity

SLC17A3 MCOLN1 CHRNG KCNK1

2.97e-03334364GO:0022836
GeneOntologyMolecularFunctionsodium channel activity

MCOLN1 KCNK1

3.96e-0352362GO:0005272
GeneOntologyMolecularFunctionG protein-coupled receptor activity

MC5R GPR3 OR5M9 GPR101 TRHR AVPR1A

4.62e-03884366GO:0004930
GeneOntologyMolecularFunctionligand-gated monoatomic ion channel activity

MCOLN1 CHRNG KCNK1

5.02e-03193363GO:0015276
GeneOntologyMolecularFunctioninorganic cation transmembrane transporter activity

SLC11A2 SLC17A3 MCOLN1 SLC5A6 KCNK1

5.06e-03627365GO:0022890
GeneOntologyMolecularFunctionligand-gated channel activity

MCOLN1 CHRNG KCNK1

5.31e-03197363GO:0022834
GeneOntologyMolecularFunctionsolute:sodium symporter activity

SLC17A3 SLC5A6

9.36e-0381362GO:0015370
GeneOntologyMolecularFunctioninorganic molecular entity transmembrane transporter activity

SLC11A2 SLC17A3 MCOLN1 SLC5A6 KCNK1

1.11e-02758365GO:0015318
GeneOntologyMolecularFunctionmonocarboxylic acid transmembrane transporter activity

ABCB11 SLC5A6

1.15e-0290362GO:0008028
GeneOntologyMolecularFunctionhormone binding

MC5R AVPR1A

1.48e-02103362GO:0042562
GeneOntologyMolecularFunctionorganic anion transmembrane transporter activity

ABCB11 SLC17A3 SLC5A6

1.56e-02293363GO:0008514
GeneOntologyMolecularFunctionactive monoatomic ion transmembrane transporter activity

SLC11A2 SLC17A3 SLC5A6

1.68e-02301363GO:0022853
GeneOntologyCellularComponentbrush border membrane

SLC11A2 SLC17A3 SLC5A6 KCNK1

1.24e-0583364GO:0031526
GeneOntologyCellularComponentlysosomal membrane

LRRC8E CD74 SLC11A2 MCOLN1 PIP4P2 MFSD1

1.25e-04462366GO:0005765
GeneOntologyCellularComponentlytic vacuole membrane

LRRC8E CD74 SLC11A2 MCOLN1 PIP4P2 MFSD1

1.25e-04462366GO:0098852
GeneOntologyCellularComponentbrush border

SLC11A2 SLC17A3 SLC5A6 KCNK1

1.32e-04152364GO:0005903
GeneOntologyCellularComponentapical plasma membrane

ABCB11 SLC11A2 SLC17A3 PROM2 SLC5A6 KCNK1

1.67e-04487366GO:0016324
GeneOntologyCellularComponentvacuolar membrane

LRRC8E CD74 SLC11A2 MCOLN1 PIP4P2 MFSD1

2.07e-04507366GO:0005774
GeneOntologyCellularComponentapical part of cell

ABCB11 SLC11A2 SLC17A3 PROM2 SLC5A6 KCNK1

4.75e-04592366GO:0045177
GeneOntologyCellularComponentcluster of actin-based cell projections

SLC11A2 SLC17A3 SLC5A6 KCNK1

5.68e-04223364GO:0098862
GeneOntologyCellularComponentendosome

ABCB11 CD74 SLC11A2 HAS3 AVPR1A MCOLN1 PIP4P2 KCNK1

6.86e-041167368GO:0005768
GeneOntologyCellularComponentmitochondrial outer membrane

SLC11A2 ARMCX2 ARMCX1 APOOL

7.60e-04241364GO:0005741
GeneOntologyCellularComponentcell projection membrane

SLC11A2 SLC17A3 PROM2 SLC5A6 KCNK1

8.10e-04431365GO:0031253
GeneOntologyCellularComponentorganelle outer membrane

SLC11A2 ARMCX2 ARMCX1 APOOL

1.31e-03279364GO:0031968
GeneOntologyCellularComponentouter membrane

SLC11A2 ARMCX2 ARMCX1 APOOL

1.34e-03281364GO:0019867
GeneOntologyCellularComponentlysosome

LRRC8E CD74 SLC11A2 MCOLN1 PIP4P2 MFSD1

2.41e-03811366GO:0005764
GeneOntologyCellularComponentlytic vacuole

LRRC8E CD74 SLC11A2 MCOLN1 PIP4P2 MFSD1

2.41e-03811366GO:0000323
GeneOntologyCellularComponentlate endosome

CD74 SLC11A2 MCOLN1 PIP4P2

2.92e-03348364GO:0005770
GeneOntologyCellularComponentlate endosome membrane

SLC11A2 MCOLN1 PIP4P2

3.58e-03179363GO:0031902
GeneOntologyCellularComponentbasal part of cell

ABCB11 SLC11A2 PROM2 SLC5A6

3.93e-03378364GO:0045178
GeneOntologyCellularComponentendocytic vesicle

CD74 AVPR1A MCOLN1 PIP4P2

4.15e-03384364GO:0030139
GeneOntologyCellularComponentvacuole

LRRC8E CD74 SLC11A2 MCOLN1 PIP4P2 MFSD1

4.33e-03913366GO:0005773
GeneOntologyCellularComponentendocytic vesicle membrane

CD74 MCOLN1 PIP4P2

5.74e-03212363GO:0030666
GeneOntologyCellularComponentrecycling endosome

ABCB11 SLC11A2 KCNK1

6.52e-03222363GO:0055037
GeneOntologyCellularComponentphagocytic vesicle membrane

MCOLN1 PIP4P2

8.99e-0383362GO:0030670
DomainARM-rpt_dom

ARMCX2 ARMCX1

1.86e-0411352IPR006911
DomainArm_2

ARMCX2 ARMCX1

1.86e-0411352PF04826
DomainGPCR_Rhodpsn_7TM

MC5R GPR3 OR5M9 GPR101 TRHR AVPR1A

1.39e-03670356IPR017452
Domain7tm_1

MC5R GPR3 OR5M9 GPR101 TRHR AVPR1A

1.47e-03677356PF00001
DomainG_PROTEIN_RECEP_F1_1

MC5R GPR3 OR5M9 GPR101 TRHR AVPR1A

1.56e-03685356PS00237
DomainG_PROTEIN_RECEP_F1_2

MC5R GPR3 OR5M9 GPR101 TRHR AVPR1A

1.63e-03691356PS50262
DomainGPCR_Rhodpsn

MC5R GPR3 OR5M9 GPR101 TRHR AVPR1A

1.64e-03692356IPR000276
DomainARM

ARMCX2 ARMCX1

2.54e-0340352SM00185
DomainARM_REPEAT

ARMCX2 ARMCX1

2.54e-0340352PS50176
DomainArmadillo

ARMCX2 ARMCX1

3.50e-0347352IPR000225
DomainMFS

SLC17A3 MFSD1

9.14e-0377352IPR011701
DomainMFS_1

SLC17A3 MFSD1

9.14e-0377352PF07690
DomainMFS

SLC17A3 MFSD1

1.74e-02108352PS50850
Domain7TM_GPCR_Srsx

MC5R TRHR

1.86e-02112352SM01381
PathwayWP_IRON_METABOLISM_IN_PLACENTA

SLC11A2 MCOLN1

1.81e-0412242M39660
PathwayWP_GPCRS_PEPTIDE

MC5R TRHR AVPR1A

2.20e-0470243MM15959
PathwayWP_GPCRS_CLASS_A_RHODOPSINLIKE

MC5R GPR3 TRHR AVPR1A

2.54e-04186244MM15994
PathwayWP_PEPTIDE_GPCRS

MC5R TRHR AVPR1A

2.70e-0475243M39696
PathwayWP_GPCRS_CLASS_A_RHODOPSINLIKE

MC5R GPR3 TRHR AVPR1A

8.98e-04260244M39397
PathwayKEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION

MC5R TRHR AVPR1A CHRNG

1.06e-03272244M13380
Pubmed

ARMCX Family Gene Expression Analysis and Potential Prognostic Biomarkers for Prediction of Clinical Outcome in Patients with Gastric Carcinoma.

ARMCX2 ARMCX1

1.04e-06236232685472
Pubmed

Synergic effect of polymorphisms in ERCC6 5' flanking region and complement factor H on age-related macular degeneration predisposition.

CFH ERCC6

1.04e-06236216754848
Pubmed

ALEX1, a novel human armadillo repeat protein that is expressed differentially in normal tissues and carcinomas.

ARMCX2 ARMCX1

3.12e-06336211162520
Pubmed

The Eutherian Armcx genes regulate mitochondrial trafficking in neurons and interact with Miro and Trak2.

ARMCX2 ARMCX1

5.70e-051136222569362
Pubmed

Polymorphisms in C2, CFB and C3 are associated with progression to advanced age related macular degeneration associated with visual loss.

CFH ERCC6

9.41e-051436219015224
Pubmed

New murine polymorphisms detected by random amplified polymorphic DNA (RAPD) PCR and mapped by use of recombinant inbred strains.

CFH CHRNG

9.41e-05143627894156
Pubmed

Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment.

CAMK1 TRHR AVPR1A CHRNG

2.57e-0430036419086053
Pubmed

Mammalian BEX, WEX and GASP genes: coding and non-coding chimaerism sustained by gene conversion events.

ARMCX2 ARMCX1

2.83e-042436216221301
Pubmed

A Grhl2-dependent gene network controls trophoblast branching morphogenesis.

PROM2 KCNK1

3.60e-042736225758223
Pubmed

Systematic protein-protein interaction mapping for clinically relevant human GPCRs.

CD74 YIF1B MCOLN1 TSPAN3 SLC5A6

7.18e-0469736528298427
Pubmed

A BioID-Derived Proximity Interactome for SARS-CoV-2 Proteins.

TMEM128 MCOLN1 PIP4P2 FAM8A1 TSPAN3

8.26e-0471936535337019
Pubmed

Association study of 182 candidate genes in anorexia nervosa.

MC5R CAMK1 AVPR1A

8.86e-0418236320468064
CytobandXq21.33-q22.2

ARMCX2 ARMCX1

5.98e-072362Xq21.33-q22.2
GeneFamilyArmadillo repeat containing|Protein phosphatase 1 regulatory subunits

ARMCX2 ARMCX1

1.73e-0343262409
GeneFamilyG protein-coupled receptors, Class A orphans

GPR3 GPR101

5.58e-0378262262
GeneFamilySolute carriers

SLC11A2 SLC17A3 SLC5A6

1.85e-02395263752
CoexpressionAtlasDevelopingLowerUrinaryTract_P1_bladder_B_emap-30374_k-means-cluster#3_top-relative-expression-ranked_1000

LRRC8E AVPR1A PROM2 KCNK1

3.73e-05122334gudmap_developingLowerUrinaryTract_P1_bladder_B_1000_k3
DrugAdamantamine fumarate [80789-67-9]; Up 200; 9.6uM; MCF7; HT_HG-U133A

GPR3 DENND4A CAMK1 ERCC6 MCOLN1

1.36e-051963654806_UP
DrugChlordiazepoxide

ABCB11 TRHR

1.46e-054362ctd:D002707
DiseaseAge-related macular degeneration

CFH ERCC6

2.07e-0418352cv:C0242383
DiseaseArthrogryposis

ERCC6 CHRNG

2.83e-0421352C0003886
DiseaseAge related macular degeneration

CFH ERCC6

5.82e-0430352C0242383

Protein segments in the cluster

PeptideGeneStartEntry
WGAAGILCYVGAYVF

TSPAN3

21

O60637
CWIIFNGTIYIYTIC

CFAP54

241

Q96N23
LYCNVLVSPDGCIYW

CHRNG

126

P07510
CLIFLCYALAFWYGS

ABCB11

331

O95342
IVCGYNGWSDLPICY

CFH

551

P08603
GIYYCWRQGVLVAGF

FAM187A

341

A6NFU0
AAGIVIGAGAWYCVY

ARMCX2

11

Q7L311
RHCYGLWFICLPAYV

DENND4A

766

Q7Z401
CVAVIYLGYCFCGWI

MCOLN1

431

Q9GZU1
YLGYCFCGWIVLGPY

MCOLN1

436

Q9GZU1
GYWSCYCLLLLFSLG

ACP7

6

Q6ZNF0
FGYKFWCGATCLGYI

ERCC6

761

P0DP91
GVGCVCCLLWFVVIY

SLC17A3

161

O00476
WCFGFLVLGYLLYLV

KCNK1

21

O00180
LWLIFIICVCYYVAV

MFSD1

266

Q9H3U5
VVLGCYFGPAALYIW

SLC11A2

361

P49281
CIYGLTCIYTLYWLF

LRRC8E

321

Q6NSJ5
WLFFLQCCIHPYVYG

GPR101

441

Q96P66
FAACWLPFTVYCLLG

GPR3

256

P46089
CWSIGVIAYILLCGY

CAMK1

201

Q14012
CLLVLFVWYCYHVGR

ASPHD2

66

Q6ICH7
LWAYIACACGLFIYQ

CEPT1

116

Q9Y6K0
IWAFCTGCGIVFILY

MC5R

166

P33032
AFLVSGAILYGCYWV

HAS3

511

O00219
LQCYGSIGYCWCVFP

CD74

241

P04233
YRLLVCFYEIICIWG

FAM8A1

311

Q9UBU6
ATGCYIGWCKGVYVF

APOOL

71

Q6UXV4
SIYGSWVYGYVGCLC

TRHR

86

P34981
WVYGYVGCLCITYLQ

TRHR

91

P34981
GTQYWFLGCCYFLGL

SLC5A6

96

Q9Y289
YLLGLICLIRACYWG

PIP4P2

231

Q8N4L2
ICTLWTYGLYFCGNF

OR5M9

156

Q8NGP3
IGAGACYCVYRLAWG

ARMCX1

16

Q9P291
LLFGKIGYYLVLGWC

YIF1B

241

Q5BJH7
IGYYLVLGWCCVAIF

YIF1B

246

Q5BJH7
AFYCIVYLEWYCGIG

TMEM128

96

Q5BJH2
YETYRWIVGCVLCSV

PROM2

421

Q8N271
ILGTCYGFICYNIWC

AVPR1A

231

P37288
YGQCWVFAGVLCTVL

TGM6

271

O95932