Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	aspartic-type endopeptidase activity	ERVK-6 ERVK-18 ERVK-19 ERVK-7 ERVK-21 ERVK-25 ERVK-10 ERVK-24	5.16e-14	37	53	8	GO:0004190
GeneOntologyMolecularFunction	aspartic-type peptidase activity	ERVK-6 ERVK-18 ERVK-19 ERVK-7 ERVK-21 ERVK-25 ERVK-10 ERVK-24	6.52e-14	38	53	8	GO:0070001
GeneOntologyMolecularFunction	CoA-transferase activity	ACSM3 OXCT1 OXCT2	1.76e-07	5	53	3	GO:0008410
GeneOntologyMolecularFunction	structural molecule activity	RPL23 ERVK-6 RPL27 MAP1A AHNAK ERVK-18 ERVK-19 ERVK-7 ERVK-21 ERVK-25 ERVK-10 ERVK-24 RIMS2	4.08e-07	891	53	13	GO:0005198
GeneOntologyMolecularFunction	peptidase activity	PRSS35 ERVK-6 DPEP3 ERVK-18 ERVK-19 ERVK-7 ERVK-21 ERVK-25 ERVK-10 ERVK-24 NPEPL1	9.32e-07	654	53	11	GO:0008233
GeneOntologyMolecularFunction	endopeptidase activity	PRSS35 ERVK-6 ERVK-18 ERVK-19 ERVK-7 ERVK-21 ERVK-25 ERVK-10 ERVK-24	1.75e-06	430	53	9	GO:0004175
GeneOntologyMolecularFunction	RNA endonuclease activity	ERVK-6 SLFN13 ERVK-7 SLFN11 ERVK-10	2.11e-06	79	53	5	GO:0004521
GeneOntologyMolecularFunction	RNA-DNA hybrid ribonuclease activity	ERVK-6 ERVK-7 ERVK-10	2.87e-06	11	53	3	GO:0004523
GeneOntologyMolecularFunction	ATP-dependent activity	CCT6A IQCA1L ACSM3 SMC3 SLFN13 DDX54 CCT6B ACSM5 SLFN11 TOP2B	4.16e-06	614	53	10	GO:0140657
GeneOntologyMolecularFunction	RNA-directed DNA polymerase activity	ERVK-6 ERVK-7 ERVK-10	6.30e-06	14	53	3	GO:0003964
GeneOntologyMolecularFunction	succinyl-CoA:3-oxo-acid CoA-transferase activity	OXCT1 OXCT2	6.91e-06	2	53	2	GO:0008260
GeneOntologyMolecularFunction	C-acyltransferase activity	ACSM3 SCP2 ACSM5	2.27e-05	21	53	3	GO:0016408
GeneOntologyMolecularFunction	RNA stem-loop binding	ERVK-6 ERVK-7 ERVK-10	2.27e-05	21	53	3	GO:0035613
GeneOntologyMolecularFunction	RNA nuclease activity	ERVK-6 SLFN13 ERVK-7 SLFN11 ERVK-10	3.00e-05	136	53	5	GO:0004540
GeneOntologyMolecularFunction	endonuclease activity	ERVK-6 SLFN13 ERVK-7 SLFN11 ERVK-10	3.00e-05	136	53	5	GO:0004519
GeneOntologyMolecularFunction	transition metal ion binding	ERVK-6 GALNT2 TRIM32 SLFN13 ERVK-19 KDM2A ERVK-7 SLFN11 ERVK-21 ERVK-10 ERVK-24 NPEPL1	5.15e-05	1189	53	12	GO:0046914
GeneOntologyMolecularFunction	zinc ion binding	ERVK-6 TRIM32 SLFN13 ERVK-19 KDM2A ERVK-7 SLFN11 ERVK-21 ERVK-10 ERVK-24	1.01e-04	891	53	10	GO:0008270
GeneOntologyMolecularFunction	RNA endonuclease activity, producing 5'-phosphomonoesters	ERVK-6 ERVK-7 ERVK-10	1.29e-04	37	53	3	GO:0016891
GeneOntologyMolecularFunction	DNA polymerase activity	ERVK-6 ERVK-7 ERVK-10	1.39e-04	38	53	3	GO:0034061
GeneOntologyMolecularFunction	ATP hydrolysis activity	CCT6A IQCA1L SMC3 SLFN13 DDX54 CCT6B SLFN11	1.57e-04	441	53	7	GO:0016887
GeneOntologyMolecularFunction	fatty-acyl-CoA synthase activity	ACSM3 ACSM5	1.92e-04	8	53	2	GO:0004321
GeneOntologyMolecularFunction	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	ERVK-6 ERVK-7 ERVK-10	2.47e-04	46	53	3	GO:0016893
GeneOntologyMolecularFunction	nuclease activity	ERVK-6 SLFN13 ERVK-7 SLFN11 ERVK-10	3.62e-04	231	53	5	GO:0004518
GeneOntologyMolecularFunction	medium-chain fatty acid-CoA ligase activity	ACSM3 ACSM5	3.74e-04	11	53	2	GO:0031956
GeneOntologyMolecularFunction	N6-methyladenosine-containing RNA reader activity	YTHDF1 YTHDC1	7.10e-04	15	53	2	GO:1990247
GeneOntologyMolecularFunction	catalytic activity, acting on RNA	ERVK-6 SLFN13 DDX54 ERVK-7 SLFN11 ERVK-10	8.01e-04	417	53	6	GO:0140098
GeneOntologyMolecularFunction	transferase activity, transferring sulphur-containing groups	ACSM3 OXCT1 OXCT2	1.00e-03	74	53	3	GO:0016782
GeneOntologyMolecularFunction	mechanosensitive monoatomic ion channel activity	PIEZO2 TRPV4	1.03e-03	18	53	2	GO:0008381
GeneOntologyMolecularFunction	catalytic activity, acting on a nucleic acid	ERVK-6 SLFN13 DDX54 ERVK-7 SLFN11 ERVK-10 TOP2B	1.51e-03	645	53	7	GO:0140640
GeneOntologyMolecularFunction	fatty-acyl-CoA binding	ACADS SCP2	1.54e-03	22	53	2	GO:0000062
GeneOntologyMolecularFunction	fatty acid derivative binding	ACADS SCP2	1.84e-03	24	53	2	GO:1901567
GeneOntologyMolecularFunction	protein-RNA adaptor activity	YTHDF1 YTHDC1	1.84e-03	24	53	2	GO:0140517
GeneOntologyMolecularFunction	fatty acid ligase activity	ACSM3 ACSM5	2.16e-03	26	53	2	GO:0015645
GeneOntologyMolecularFunction	acyl-CoA binding	ACADS SCP2	2.16e-03	26	53	2	GO:0120227
GeneOntologyMolecularFunction	CoA-ligase activity	ACSM3 ACSM5	2.33e-03	27	53	2	GO:0016405
GeneOntologyMolecularFunction	acid-thiol ligase activity	ACSM3 ACSM5	3.06e-03	31	53	2	GO:0016878
GeneOntologyMolecularFunction	acyltransferase activity, transferring groups other than amino-acyl groups	ACSM3 SCP2 ACSM5 ALAS1	3.65e-03	238	53	4	GO:0016747
GeneOntologyMolecularFunction	ribonucleoside triphosphate phosphatase activity	CCT6A IQCA1L SMC3 SLFN13 DDX54 CCT6B SLFN11	4.21e-03	775	53	7	GO:0017111
GeneOntologyMolecularFunction	ATP-dependent protein folding chaperone	CCT6A CCT6B	5.05e-03	40	53	2	GO:0140662
GeneOntologyMolecularFunction	catalytic activity, acting on DNA	ERVK-6 ERVK-7 ERVK-10 TOP2B	5.12e-03	262	53	4	GO:0140097
GeneOntologyMolecularFunction	ligase activity, forming carbon-sulfur bonds	ACSM3 ACSM5	5.30e-03	41	53	2	GO:0016877
GeneOntologyMolecularFunction	pyrophosphatase activity	CCT6A IQCA1L SMC3 SLFN13 DDX54 CCT6B SLFN11	6.45e-03	839	53	7	GO:0016462
GeneOntologyMolecularFunction	hydrolase activity, acting on acid anhydrides	CCT6A IQCA1L SMC3 SLFN13 DDX54 CCT6B SLFN11	6.49e-03	840	53	7	GO:0016817
GeneOntologyMolecularFunction	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	CCT6A IQCA1L SMC3 SLFN13 DDX54 CCT6B SLFN11	6.49e-03	840	53	7	GO:0016818
GeneOntologyMolecularFunction	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	DHRS4L1 ALDH9A1	7.21e-03	48	53	2	GO:0016620
GeneOntologyMolecularFunction	beta-tubulin binding	SMC3 TRPV4	7.51e-03	49	53	2	GO:0048487
GeneOntologyMolecularFunction	nucleotidyltransferase activity	ERVK-6 ERVK-7 ERVK-10	7.67e-03	152	53	3	GO:0016779
GeneOntologyMolecularFunction	molecular adaptor activity	YTHDF1 KMT2D MAP1A TRIM32 DDX54 KDM2A FIS1 YTHDC1 RIMS2	8.80e-03	1356	53	9	GO:0060090
GeneOntologyMolecularFunction	pyridoxal phosphate binding	SGPL1 ALAS1	9.71e-03	56	53	2	GO:0030170
GeneOntologyMolecularFunction	oxidoreductase activity, acting on the aldehyde or oxo group of donors	DHRS4L1 ALDH9A1	9.71e-03	56	53	2	GO:0016903
GeneOntologyMolecularFunction	vitamin B6 binding	SGPL1 ALAS1	1.00e-02	57	53	2	GO:0070279
GeneOntologyMolecularFunction	protein-macromolecule adaptor activity	YTHDF1 KMT2D MAP1A TRIM32 DDX54 KDM2A YTHDC1 RIMS2	1.09e-02	1160	53	8	GO:0030674
GeneOntologyBiologicalProcess	DNA integration	ERVK-6 ERVK-7 ERVK-10	4.50e-06	13	53	3	GO:0015074
GeneOntologyBiologicalProcess	ketone body catabolic process	OXCT1 OXCT2	1.94e-05	3	53	2	GO:0046952
GeneOntologyBiologicalProcess	viral process	ERVK-6 TRIM32 ERVK-19 ERVK-7 ERVK-21 ERVK-10 ERVK-24 TOP2B	2.25e-05	464	53	8	GO:0016032
GeneOntologyBiologicalProcess	RNA-templated DNA biosynthetic process	ERVK-6 CCT6A ERVK-7 ERVK-10	6.14e-05	83	53	4	GO:0006278
GeneOntologyCellularComponent	chaperonin-containing T-complex	CCT6A CCT6B	3.29e-04	11	52	2	GO:0005832
GeneOntologyCellularComponent	microbody	HSDL2 DHRS4L1 SCP2 FIS1	7.04e-04	162	52	4	GO:0042579
GeneOntologyCellularComponent	peroxisome	HSDL2 DHRS4L1 SCP2 FIS1	7.04e-04	162	52	4	GO:0005777
Domain	CoA_transf_AS	OXCT1 OXCT2	5.42e-06	2	44	2	IPR004164
Domain	CoA_trans_fam_I	OXCT1 OXCT2	5.42e-06	2	44	2	IPR004165
Domain	CoA_transf_BS	OXCT1 OXCT2	5.42e-06	2	44	2	IPR004163
Domain	CoA_trans	OXCT1 OXCT2	5.42e-06	2	44	2	PF01144
Domain	3-oxoacid_CoA-transf_A	OXCT1 OXCT2	5.42e-06	2	44	2	IPR012792
Domain	3-oxoacid_CoA-transf_B	OXCT1 OXCT2	5.42e-06	2	44	2	IPR012791
Domain	CoA_trans	OXCT1 OXCT2	5.42e-06	2	44	2	SM00882
Domain	3-oxoacid_CoA-transferase	OXCT1 OXCT2	5.42e-06	2	44	2	IPR014388
Domain	Chap_CCT_zeta	CCT6A CCT6B	5.42e-06	2	44	2	IPR012722
Domain	COA_TRANSF_2	OXCT1 OXCT2	5.42e-06	2	44	2	PS01274
Domain	COA_TRANSF_1	OXCT1 OXCT2	5.42e-06	2	44	2	PS01273
Domain	DUF2075	SLFN13 SLFN11	1.62e-05	3	44	2	IPR018647
Domain	DUF2075	SLFN13 SLFN11	1.62e-05	3	44	2	PF09848
Domain	SCP2_sterol-bd_dom	HSDL2 SCP2	5.40e-05	5	44	2	IPR003033
Domain	YTH	YTHDF1 YTHDC1	5.40e-05	5	44	2	PS50882
Domain	YTH_domain	YTHDF1 YTHDC1	5.40e-05	5	44	2	IPR007275
Domain	-	HSDL2 SCP2	5.40e-05	5	44	2	3.30.1050.10
Domain	YTH	YTHDF1 YTHDC1	5.40e-05	5	44	2	PF04146
Domain	SCP2	HSDL2 SCP2	5.40e-05	5	44	2	PF02036
Domain	AlbA_2	SLFN13 SLFN11	1.13e-04	7	44	2	PF04326
Domain	Schlafen	SLFN13 SLFN11	1.13e-04	7	44	2	IPR029684
Domain	Schlafen_AAA_dom	SLFN13 SLFN11	1.13e-04	7	44	2	IPR007421
Domain	Chaperonin_TCP-1_CS	CCT6A CCT6B	1.93e-04	9	44	2	IPR002194
Domain	Chaprnin_Cpn60	CCT6A CCT6B	1.93e-04	9	44	2	IPR001844
Domain	Chaperone_TCP-1	CCT6A CCT6B	2.41e-04	10	44	2	IPR017998
Domain	TCP1_1	CCT6A CCT6B	2.41e-04	10	44	2	PS00750
Domain	TCP1_2	CCT6A CCT6B	2.41e-04	10	44	2	PS00751
Domain	TCP1_3	CCT6A CCT6B	2.41e-04	10	44	2	PS00995
Domain	-	CCT6A CCT6B	2.94e-04	11	44	2	3.30.260.10
Domain	TCP-1-like_intermed	CCT6A CCT6B	2.94e-04	11	44	2	IPR027410
Domain	SDR_fam	HSDL2 DHRS4L1 SCP2	3.10e-04	56	44	3	IPR002347
Domain	-	CCT6A CCT6B	4.85e-04	14	44	2	1.10.560.10
Domain	GROEL-like_equatorial	CCT6A CCT6B	4.85e-04	14	44	2	IPR027413
Domain	Cpn60/TCP-1	CCT6A CCT6B	5.59e-04	15	44	2	IPR002423
Domain	Cpn60_TCP1	CCT6A CCT6B	5.59e-04	15	44	2	PF00118
Domain	-	CCT6A CCT6B	5.59e-04	15	44	2	3.50.7.10
Domain	GroEL-like_apical_dom	CCT6A CCT6B	5.59e-04	15	44	2	IPR027409
Domain	AMP-bd_C	ACSM3 ACSM5	7.21e-04	17	44	2	IPR025110
Domain	AMP-binding_C	ACSM3 ACSM5	7.21e-04	17	44	2	PF13193
Domain	AMP-binding_CS	ACSM3 ACSM5	1.70e-03	26	44	2	IPR020845
Domain	AMP_BINDING	ACSM3 ACSM5	1.97e-03	28	44	2	PS00455
Domain	AMP-binding	ACSM3 ACSM5	2.26e-03	30	44	2	PF00501
Domain	AMP-dep_Synth/Lig	ACSM3 ACSM5	2.26e-03	30	44	2	IPR000873
Domain	Sc_DH/Rdtase_CS	HSDL2 DHRS4L1	3.07e-03	35	44	2	IPR020904
Domain	-	SGPL1 ALAS1	3.80e-03	39	44	2	3.40.640.10
Domain	PyrdxlP-dep_Trfase	SGPL1 ALAS1	4.20e-03	41	44	2	IPR015424
Domain	PyrdxlP-dep_Trfase_major_sub1	SGPL1 ALAS1	4.20e-03	41	44	2	IPR015421
Pathway	KEGG_BUTANOATE_METABOLISM	ACSM3 OXCT1 ACADS OXCT2 ACSM5 ALDH9A1	1.31e-10	34	33	6	M3397
Pathway	KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION	OXCT1 ACADS OXCT2 ALDH9A1	3.16e-06	44	33	4	M11835
Pathway	REACTOME_UTILIZATION_OF_KETONE_BODIES	OXCT1 OXCT2	3.18e-05	4	33	2	MM15459
Pathway	REACTOME_BETA_OXIDATION_OF_BUTANOYL_COA_TO_ACETYL_COA	ACSM3 ACADS	5.29e-05	5	33	2	M27725
Pathway	WP_17Q12_COPY_NUMBER_VARIATION_SYNDROME	RPL23 SLFN13 CCT6B SLFN11	8.01e-05	99	33	4	M46448
Pathway	REACTOME_FOLDING_OF_ACTIN_BY_CCT_TRIC	CCT6A CCT6B	2.36e-04	10	33	2	M27299
Pathway	REACTOME_KETONE_BODY_METABOLISM	OXCT1 OXCT2	2.36e-04	10	33	2	MM15437
Pathway	REACTOME_ASSOCIATION_OF_TRIC_CCT_WITH_TARGET_PROTEINS_DURING_BIOSYNTHESIS	CCT6A CCT6B	2.36e-04	10	33	2	MM15004
Pathway	REACTOME_KETONE_BODY_METABOLISM	OXCT1 OXCT2	2.36e-04	10	33	2	M27706
Pathway	REACTOME_METABOLISM_OF_LIPIDS	ACSM3 OXCT1 ACADS SGPL1 DPEP3 OXCT2 SCP2 ALAS1	2.79e-04	757	33	8	M27451
Pathway	REACTOME_MITOCHONDRIAL_FATTY_ACID_BETA_OXIDATION_OF_SATURATED_FATTY_ACIDS	ACSM3 ACADS	2.88e-04	11	33	2	M27719
Pathway	WP_MITOCHONDRIAL_LONG_CHAIN_FATTY_ACID_BETAOXIDATION	ACADS SCP2	6.25e-04	16	33	2	MM15841
Pathway	WP_MITOCHONDRIAL_LONG_CHAIN_FATTY_ACID_BETAOXIDATION	ACADS SCP2	7.07e-04	17	33	2	M39365
Pathway	REACTOME_FATTY_ACID_METABOLISM	ACSM3 ACADS DPEP3 SCP2	7.24e-04	176	33	4	M27854
Pathway	WP_16P112_PROXIMAL_DELETION_SYNDROME	CCT6A KMT2D CCT6B	7.31e-04	76	33	3	M40057
Pathway	WP_MITOCHONDRIAL_FATTY_ACID_OXIDATION_DISORDERS	ACADS SCP2	8.86e-04	19	33	2	M48049
Pathway	KEGG_MEDICUS_REFERENCE_ASSEMBLY_AND_TRAFFICKING_OF_TELOMERASE	CCT6A CCT6B	8.86e-04	19	33	2	M47863
Pathway	REACTOME_FORMATION_OF_TUBULIN_FOLDING_INTERMEDIATES_BY_CCT_TRIC	CCT6A CCT6B	1.67e-03	26	33	2	M9648
Pathway	REACTOME_PROTEIN_LOCALIZATION	DHRS4L1 SCP2 FIS1	1.76e-03	103	33	3	MM15653
Pathway	REACTOME_NONSENSE_MEDIATED_DECAY_NMD	RPL23 RPL27 SMG8	2.41e-03	115	33	3	MM15640
Pathway	REACTOME_NONSENSE_MEDIATED_DECAY_NMD	RPL23 RPL27 SMG8	2.47e-03	116	33	3	M27921
Pathway	REACTOME_COOPERATION_OF_PREFOLDIN_AND_TRIC_CCT_IN_ACTIN_AND_TUBULIN_FOLDING	CCT6A CCT6B	2.68e-03	33	33	2	M27297
Pathway	REACTOME_METABOLISM_OF_LIPIDS	OXCT1 ACADS SGPL1 DPEP3 OXCT2 SCP2	2.83e-03	620	33	6	MM15193
Pubmed	Quantitation of HERV-K env gene expression and splicing in human breast cancer.	ERVK-6 ERVK-18 ERVK-19 ERVK-7 ERVK-21	6.77e-15	5	53	5	12629516
Pubmed	A revised nomenclature for transcribed human endogenous retroviral loci.	ERVK-6 ERVK-18 ERVK-19 ERVK-7 ERVK-21 ERVK-25 ERVK-10 ERVK-24	1.68e-12	94	53	8	21542922
Pubmed	Many human endogenous retrovirus K (HERV-K) proviruses are unique to humans.	ERVK-6 ERVK-7 ERVK-10 ERVK-24	4.80e-12	4	53	4	10469592
Pubmed	Expression patterns of transcribed human endogenous retrovirus HERV-K(HML-2) loci in human tissues and the need for a HERV Transcriptome Project.	ERVK-18 ERVK-21 ERVK-25 ERVK-10 ERVK-24	5.71e-11	18	53	5	18664271
Pubmed	Genome-wide screening, cloning, chromosomal assignment, and expression of full-length human endogenous retrovirus type K.	ERVK-6 ERVK-18 ERVK-19	3.34e-09	3	53	3	10516026
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	RPL23 RPL27 CCT6A SMG8 OXCT1 SMC3 TRIM32 SGPL1 AHNAK DDX54 CCT6B KDM2A ALDH9A1 TOP2B	9.87e-09	1353	53	14	29467282
Pubmed	Human endogenous retrovirus K10: expression of Gag protein and detection of antibodies in patients with seminomas.	ERVK-6 ERVK-19 ERVK-10	1.34e-08	4	53	3	7983737
Pubmed	Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria.	RPL23 ACSM3 OXCT1 ACADS HSDL2 DHRS4L1 OXCT2 SCP2 FIS1	1.22e-07	542	53	9	14651853
Pubmed	Survey of human genes of retroviral origin: identification and transcriptome of the genes with coding capacity for complete envelope proteins.	ERVK-6 ERVK-19 ERVK-21	3.98e-07	10	53	3	12970426
Pubmed	A mitochondrial protein compendium elucidates complex I disease biology.	PRSS35 ACSM3 OXCT1 ACADS HSDL2 DHRS4L1 OXCT2 SCP2 FIS1 ALAS1 ALDH9A1	4.18e-07	1047	53	11	18614015
Pubmed	Genomewide screening for fusogenic human endogenous retrovirus envelopes identifies syncytin 2, a gene conserved on primate evolution.	ERVK-6 ERVK-19 ERVK-21	7.28e-07	12	53	3	14557543
Pubmed	Mitochondrial protein interactome elucidated by chemical cross-linking mass spectrometry.	OXCT1 ACADS HSDL2 DHRS4L1 OXCT2 SCP2 FIS1	8.91e-07	343	53	7	28130547
Pubmed	Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.	PRSS35 ACSM3 OXCT1 ACADS HSDL2 SCP2 ACSM5 FIS1 ALAS1 ALDH9A1	1.18e-06	926	53	10	20877624
Pubmed	NOTCH1 nuclear interactome reveals key regulators of its transcriptional activity and oncogenic function.	CCT6A SMC3 TRIM32 SLFN11 TOP2B	1.62e-06	129	53	5	23022380
Pubmed	Differential expression of succinyl CoA transferase (SCOT) genes in somatic and germline cells of the mouse testis.	OXCT1 OXCT2	2.28e-06	2	53	2	12534938
Pubmed	Mouse Slfn8 and Slfn9 genes complement human cells lacking SLFN11 during the replication stress response.	SLFN13 SLFN11	2.28e-06	2	53	2	37833372
Pubmed	Expression of human endogenous retrovirus type K envelope glycoprotein in insect and mammalian cells.	ERVK-6 ERVK-19	2.28e-06	2	53	2	9060628
Pubmed	Evolutionary relationships within a subgroup of HERV-K-related human endogenous retroviruses.	ERVK-6 ERVK-19	2.28e-06	2	53	2	9460924
Pubmed	Interferon-alpha-induced endogenous superantigen. a model linking environment and autoimmunity.	ERVK-6 ERVK-18	2.28e-06	2	53	2	11672541
Pubmed	Structure of Schlafen13 reveals a new class of tRNA/rRNA- targeting RNase engaged in translational control.	SLFN13 SLFN11	2.28e-06	2	53	2	29563550
Pubmed	Systematically defining selective autophagy receptor-specific cargo using autophagosome content profiling.	RPL23 RPL27 CCT6A GALNT2 SMC3 TRIM32 AHNAK KDM2A ALDH9A1 NPEPL1 GNS	3.36e-06	1297	53	11	33545068
Pubmed	Combinatorial targeting of a chromatin complex comprising Dot1L, menin and the tyrosine kinase BAZ1B reveals a new therapeutic vulnerability of endocrine therapy-resistant breast cancer.	YTHDF1 RPL23 RPL27 CCT6A SMC3 SGPL1 DDX54 YTHDC1 TOP2B	4.90e-06	847	53	9	35850772
Pubmed	Cloning and characterization of a human orthologue of testis-specific succinyl CoA: 3-oxo acid CoA transferase (Scot-t) cDNA.	OXCT1 OXCT2	6.83e-06	3	53	2	11756565
Pubmed	Tissue-specific subunit of the mouse cytosolic chaperonin-containing TCP-1.	CCT6A CCT6B	6.83e-06	3	53	2	9013858
Pubmed	Schlafen 11 triggers innate immune responses through its ribonuclease activity upon detection of single-stranded DNA.	SLFN13 SLFN11	6.83e-06	3	53	2	38875319
Pubmed	Structural Basis for the Discriminative Recognition of N6-Methyladenosine RNA by the Human YT521-B Homology Domain Family of Proteins.	YTHDF1 YTHDC1	1.36e-05	4	53	2	26318451
Pubmed	MYC multimers shield stalled replication forks from RNA polymerase.	RPL23 RPL27 CCT6A SMC3 AHNAK DDX54 KDM2A YTHDC1 TOP2B	1.69e-05	989	53	9	36424410
Pubmed	Elf5-centered transcription factor hub controls trophoblast stem cell self-renewal and differentiation through stoichiometry-sensitive shifts in target gene networks.	RPL23 RPL27 SMC3 TOP2B	1.83e-05	102	53	4	26584622
Pubmed	Tau interactome maps synaptic and mitochondrial processes associated with neurodegeneration.	YTHDF1 RPL23 OXCT1 MAP1A AHNAK ARL6IP5 ALDH9A1	2.14e-05	558	53	7	35063084
Pubmed	Schlafen-8 is essential for lymphatic endothelial cell activation in experimental autoimmune encephalomyelitis.	SLFN13 SLFN11	2.27e-05	5	53	2	29528433
Pubmed	Subcellular localization of the Schlafen protein family.	SLFN13 SLFN11	2.27e-05	5	53	2	18355440
Pubmed	Transcriptionally active HERV-K genes: identification, isolation, and chromosomal mapping.	ERVK-6 ERVK-7	2.27e-05	5	53	2	11401426
Pubmed	Expression and regulatory effects of murine Schlafen (Slfn) genes in malignant melanoma and renal cell carcinoma.	SLFN13 SLFN11	2.27e-05	5	53	2	24089532
Pubmed	The tumour suppressor PTEN mediates a negative regulation of the E3 ubiquitin-protein ligase Nedd4.	RPL23 CCT6A OXCT1 AHNAK	2.46e-05	110	53	4	18307411
Pubmed	The interactome of intact mitochondria by cross-linking mass spectrometry provides evidence for coexisting respiratory supercomplexes.	OXCT1 ACADS HSDL2 DHRS4L1 SCP2 ALAS1	2.51e-05	382	53	6	29222160
Pubmed	Topoisomerase II-Induced Chromosome Breakage and Translocation Is Determined by Chromosome Architecture and Transcriptional Activity.	SMC3 TOP2B	3.40e-05	6	53	2	31202577
Pubmed	Schlafen, a new family of growth regulatory genes that affect thymocyte development.	SLFN13 SLFN11	3.40e-05	6	53	2	9846487
Pubmed	Human endogenous retrovirus HERV-K(HML-2) proviruses with Rec protein coding capacity and transcriptional activity.	ERVK-6 ERVK-19	3.40e-05	6	53	2	15063128
Pubmed	TLE1 modifies the effects of NOD2 in the pathogenesis of Crohn's disease.	GALNT2 FIS1	4.76e-05	7	53	2	21699783
Pubmed	Modulation of T cell development and activation by novel members of the Schlafen (slfn) gene family harbouring an RNA helicase-like motif.	SLFN13 SLFN11	4.76e-05	7	53	2	15351786
Pubmed	TRIM28-mediated nucleocapsid protein SUMOylation enhances SARS-CoV-2 virulence.	RPL23 RPL27 CCT6A SMC3 YTHDC1 TOP2B	4.85e-05	430	53	6	38172120
Pubmed	Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context.	ACSM3 OXCT1 ACADS HSDL2 OXCT2 ACSM5 FIS1 ALAS1 ALDH9A1	4.99e-05	1136	53	9	34800366
Pubmed	Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.	YTHDF1 RPL23 RPL27 CCT6A OXCT1 MAP1A ACADS ARL6IP5 ALDH9A1	5.09e-05	1139	53	9	36417873
Pubmed	ISG15 Connects Autophagy and IFN-γ-Dependent Control of Toxoplasma gondii Infection in Human Cells.	CCT6A GALNT2 AHNAK DDX54 TOP2B	5.55e-05	268	53	5	33024031
Pubmed	Defining the membrane proteome of NK cells.	RPL23 RPL27 GALNT2 HSDL2 AHNAK ARL6IP5 DDX54 SCP2 FIS1	6.17e-05	1168	53	9	19946888
Pubmed	Evolution of the Schlafen genes, a gene family associated with embryonic lethality, meiotic drive, immune processes and orthopoxvirus virulence.	SLFN13 SLFN11	6.34e-05	8	53	2	19619625
Pubmed	Antibody characterisation of two distinct conformations of the chaperonin-containing TCP-1 from mouse testis.	CCT6A CCT6B	8.15e-05	9	53	2	7828721
Pubmed	Structures and co-regulated expression of the genes encoding mouse cytosolic chaperonin CCT subunits.	CCT6A CCT6B	8.15e-05	9	53	2	10336634
Pubmed	ATG5 is required for B cell polarization and presentation of particulate antigens.	RPL27 SMC3 SGPL1 DDX54 CCT6B YTHDC1 TOP2B	9.04e-05	701	53	7	30196744
Pubmed	ER-export and ARFRP1/AP-1-dependent delivery of SARS-CoV-2 Envelope to lysosomes controls late stages of viral replication.	RPL23 RPL27 SMC3 HSDL2 SGPL1 AHNAK ARL6IP5 DDX54	9.11e-05	952	53	8	38569033
Pubmed	KAP1 facilitates reinstatement of heterochromatin after DNA replication.	RPL23 CCT6A OXCT1 MAP1A SMC3 ALDH9A1 TOP2B	9.28e-05	704	53	7	29955894
Pubmed	RNA-binding proteins with basic-acidic dipeptide (BAD) domains self-assemble and aggregate in Alzheimer's disease.	YTHDF1 RPL23 RPL27 SGPL1 DDX54 YTHDC1 TOP2B	1.00e-04	713	53	7	29802200
Pubmed	Identification of six Tcp-1-related genes encoding divergent subunits of the TCP-1-containing chaperonin.	CCT6A CCT6B	1.02e-04	10	53	2	7953530
Pubmed	LOXL2 Upregulates Phosphorylation of Ezrin to Promote Cytoskeletal Reorganization and Tumor Cell Invasion.	RPL23 RPL27 CCT6A AHNAK TOP2B	1.41e-04	327	53	5	31409639
Pubmed	The necdin interactome: evaluating the effects of amino acid substitutions and cell stress using proximity-dependent biotinylation (BioID) and mass spectrometry.	RPL23 RPL27 CCT6A SMC3 AHNAK	1.47e-04	330	53	5	32529326
Pubmed	BAP1 regulation of the key adaptor protein NCoR1 is critical for γ-globin gene repression.	RPL23 RPL27 CCT6A SMC3 HSDL2 AHNAK DDX54 YTHDC1 TOP2B	1.55e-04	1318	53	9	30463901
Pubmed	PRP19 transforms into a sensor of RPA-ssDNA after DNA damage and drives ATR activation via a ubiquitin-mediated circuitry.	YTHDF1 SMC3 AHNAK SLFN11 TOP2B	1.69e-04	340	53	5	24332808
Pubmed	The E3 ubiquitin ligase FBXL6 controls the quality of newly synthesized mitochondrial ribosomal proteins.	YTHDF1 RPL23 CCT6A SMC3 SGPL1 AHNAK	1.81e-04	547	53	6	37267103
Pubmed	A Map of Human Mitochondrial Protein Interactions Linked to Neurodegeneration Reveals New Mechanisms of Redox Homeostasis and NF-κB Signaling.	RPL27 SMC3 HSDL2 ARL6IP5 SCP2 YTHDC1 TOP2B	1.83e-04	786	53	7	29128334
Pubmed	The scaffold protein KSR1, a novel therapeutic target for the treatment of Merlin-deficient tumors.	RPL23 RPL27 CCT6A SMC3 SLFN11	1.94e-04	350	53	5	26549023
Pubmed	Genome-wide and gene-centric analyses of circulating myeloperoxidase levels in the charge and care consortia.	SMG8 GALNT2	2.05e-04	14	53	2	23620142
Pubmed	EZH2 interacts with HP1BP3 to epigenetically activate WNT7B that promotes temozolomide resistance in glioblastoma.	RPL23 RPL27 CCT6A ACADS SMC3 AHNAK CCT6B	2.09e-04	803	53	7	36517590
Pubmed	MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.	RPL23 RPL27 CCT6A MAP1A TRIM32 YTHDC1 GNS TOP2B	2.19e-04	1082	53	8	38697112
Pubmed	Ephrin-As, Eph receptors and integrin α3 interact and colocalise at membrane protrusions of U251MG glioblastoma cells.	RPL23 RPL27 SMG8 GNS	2.35e-04	197	53	4	23686814
Pubmed	The BRCT-domain containing protein PTIP links PAX2 to a histone H3, lysine 4 methyltransferase complex.	KMT2D SMC3	2.36e-04	15	53	2	17925232
Pubmed	The Chaperonin TRiC/CCT Associates with Prefoldin through a Conserved Electrostatic Interface Essential for Cellular Proteostasis.	CCT6A CCT6B	2.36e-04	15	53	2	30955883
Pubmed	LRF maintains genome integrity by regulating the non-homologous end joining pathway of DNA repair.	RPL27 CCT6A SMC3	2.43e-04	79	53	3	26446488
Pubmed	Folate receptor α increases chemotherapy resistance through stabilizing MDM2 in cooperation with PHB2 that is overcome by MORAb-202 in gastric cancer.	RPL23 RPL27 CCT6A AHNAK	2.79e-04	206	53	4	34185411
Pubmed	Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage.	YTHDF1 RPL23 RPL27 CCT6A TRIM32 AHNAK CCT6B	2.82e-04	844	53	7	25963833
Pubmed	An OBSL1-Cul7Fbxw8 ubiquitin ligase signaling mechanism regulates Golgi morphology and dendrite patterning.	CCT6A CCT6B	3.05e-04	17	53	2	21572988
Pubmed	Rewiring of the Human Mitochondrial Interactome during Neuronal Reprogramming Reveals Regulators of the Respirasome and Neurogenesis.	OXCT1 GALNT2 HSDL2 ARL6IP5 SCP2 FIS1 ALDH9A1	3.14e-04	859	53	7	31536960
Pubmed	An important role for CDK2 in G1 to S checkpoint activation and DNA damage response in human embryonic stem cells.	RPL23 RPL27 CCT6A SMC3 AHNAK	3.46e-04	397	53	5	21319273
Pubmed	Identification and functional characterization of transcriptional activators in human cells.	RPL27 KMT2D OXCT1 KDM2A SLFN11	3.50e-04	398	53	5	35016035
Pubmed	A High-Density Human Mitochondrial Proximity Interaction Network.	RPL23 CCT6A OXCT1 HSDL2 ARL6IP5 DDX54 SCP2 FIS1 ALAS1	3.94e-04	1496	53	9	32877691
Pubmed	The Hsp70-Hsp90 co-chaperone Hop/Stip1 shifts the proteostatic balance from folding towards degradation.	YTHDF1 RPL23 RPL27 CCT6A SMC3 TOP2B	4.11e-04	638	53	6	33239621
Pubmed	Mitochondrial Protein Interaction Mapping Identifies Regulators of Respiratory Chain Function.	PRSS35 OXCT1 HSDL2 OXCT2 FIS1	4.14e-04	413	53	5	27499296
Pubmed	LGALS3BP regulates centriole biogenesis and centrosome hypertrophy in cancer cells.	YTHDF1 RPL23 RPL27 CCT6A TRIM32 DDX54	4.14e-04	639	53	6	23443559
Pubmed	Suppression of ACE2 SUMOylation protects against SARS-CoV-2 infection through TOLLIP-mediated selective autophagy.	RPL23 RPL27 CCT6A DDX54 YTHDC1 TOP2B	4.21e-04	641	53	6	36057605
Pubmed	PSMD9 ribosomal protein network maintains nucleolar architecture and WT p53 levels.	RPL23 RPL27	4.25e-04	20	53	2	34077860
Pubmed	Nucleolar proteome dynamics.	RPL27 SMC3 DDX54 KDM2A TOP2B	4.42e-04	419	53	5	15635413
Pubmed	USP7 targets XIAP for cancer progression: Establishment of a p53-independent therapeutic avenue for glioma.	KMT2D AHNAK DDX54 TOP2B	4.52e-04	234	53	4	36243803
Pubmed	Broad histone H3K4me3 domains in mouse oocytes modulate maternal-to-zygotic transition.	KMT2D KDM2A	4.70e-04	21	53	2	27626377
Pubmed	Variability in Streptavidin-Sepharose Matrix Quality Can Significantly Affect Proximity-Dependent Biotinylation (BioID) Data.	OXCT1 HSDL2 ARL6IP5 DDX54 ALAS1	5.41e-04	438	53	5	32628020
Pubmed	The DNA sequence of human chromosome 7.	ERVK-6 CCT6A IQCA1L TAS2R3 FIS1	5.57e-04	441	53	5	12853948
Pubmed	PTPN14 regulates Roquin2 stability by tyrosine dephosphorylation.	YTHDF1 RPL23 RPL27 CCT6A DDX54 YTHDC1	5.66e-04	678	53	6	30209976
Pubmed	TBK1 phosphorylation activates LIR-dependent degradation of the inflammation repressor TNIP1.	RPL23 RPL27 CCT6A SMC3 AHNAK DDX54 YTHDC1	5.69e-04	949	53	7	36574265
Pubmed	SLFN11 promotes CDT1 degradation by CUL4 in response to replicative DNA damage, while its absence leads to synthetic lethality with ATR/CHK1 inhibitors.	FILIP1 DDX54 KDM2A SLFN11	5.79e-04	250	53	4	33536335
Pubmed	SETD1A Methyltransferase Is Physically and Functionally Linked to the DNA Damage Repair Protein RAD18.	KMT2D AHNAK DDX54 TOP2B	5.88e-04	251	53	4	31076518
Pubmed	Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.	RPL23 RPL27 CCT6A SMC3 SGPL1 AHNAK DDX54 YTHDC1	5.95e-04	1257	53	8	36526897
Pubmed	Multi-omics profiling identifies a deregulated FUS-MAP1B axis in ALS/FTD-associated UBQLN2 mutants.	RPL23 RPL27 CCT6A TRIM32	6.33e-04	256	53	4	35777956
Pubmed	Perturbation of the mutated EGFR interactome identifies vulnerabilities and resistance mechanisms.	YTHDF1 RPL23 SGPL1 AHNAK	6.33e-04	256	53	4	24189400
Pubmed	The Maternal Microbiome Programs the m6A Epitranscriptome of the Mouse Fetal Brain and Intestine.	YTHDF1 YTHDC1	6.68e-04	25	53	2	35874829
Pubmed	Holoprosencephaly Overview	KMT2D SMC3	6.68e-04	25	53	2	20301702
Pubmed	Upstream open reading frames cause widespread reduction of protein expression and are polymorphic among humans.	TAS2R3 HSDL2	6.68e-04	25	53	2	19372376
Pubmed	Circular RNA circPVT1 promotes nasopharyngeal carcinoma metastasis via the β-TrCP/c-Myc/SRSF1 positive feedback loop.	YTHDF1 RPL23 HSDL2 TRIM32	6.70e-04	260	53	4	36199071
Pubmed	SARS-CoV-2 nucleocapsid protein binds host mRNAs and attenuates stress granules to impair host stress response.	RPL23 RPL27 CCT6A SLFN11 GNS	6.94e-04	463	53	5	34901782
Pubmed	BioID-based intact cell interactome of the Kv1.3 potassium channel identifies a Kv1.3-STAT3-p53 cellular signaling pathway.	RPL23 RPL27 CCT6A SMC3 AHNAK ARL6IP5	7.09e-04	708	53	6	39231216
Pubmed	Histone methyltransferase DOT1L coordinates AR and MYC stability in prostate cancer.	RPL23 CCT6A KMT2D TRIM32	7.10e-04	264	53	4	32814769
Pubmed	Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions.	RPL27 MAP1A SGPL1 AHNAK CCT6B SLFN11 RIMS2 NPEPL1	7.15e-04	1293	53	8	15342556
Pubmed	H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.	RPL23 RPL27 KMT2D AHNAK DDX54 KDM2A YTHDC1 TOP2B	7.19e-04	1294	53	8	30804502
Interaction	ELF5 interactions	RPL23 RPL27 KMT2D SMC3 TOP2B	2.84e-05	147	49	5	int:ELF5
Interaction	ERVK-6 interactions	ERVK-6 ARL6IP5	3.46e-05	4	49	2	int:ERVK-6
Interaction	OXCT2 interactions	OXCT1 OXCT2 CCT6B	5.24e-05	30	49	3	int:OXCT2
Interaction	MAPT interactions	YTHDF1 RPL23 RPL27 OXCT1 MAP1A SMC3 AHNAK ARL6IP5 CCT6B ALDH9A1 NPEPL1	6.10e-05	1119	49	11	int:MAPT
Interaction	MIPEP interactions	ACSM3 HSDL2 ACSM5 RIMS2	6.19e-05	88	49	4	int:MIPEP
Interaction	CAPN10 interactions	CCT6A MAP1A CCT6B	6.38e-05	32	49	3	int:CAPN10
Interaction	PLA2G15 interactions	CCT6A CCT6B GNS	8.37e-05	35	49	3	int:PLA2G15
Cytoband	Ensembl 112 genes in cytogenetic band chr17q12	RPL23 SLFN13 CCT6B SLFN11	2.56e-05	149	52	4	chr17q12
Cytoband	17q12	SLFN13 CCT6B SLFN11	1.99e-04	99	52	3	17q12
GeneFamily	Schlafen family	SLFN13 SLFN11	4.83e-05	7	28	2	1110
GeneFamily	Chaperonins	CCT6A CCT6B	2.40e-04	15	28	2	587
GeneFamily	Acyl-CoA synthetase family	ACSM3 ACSM5	7.35e-04	26	28	2	40
GeneFamily	L ribosomal proteins	RPL23 RPL27	2.81e-03	51	28	2	729
GeneFamily	Short chain dehydrogenase/reductase superfamily	HSDL2 DHRS4L1	6.14e-03	76	28	2	743
GeneFamily	PHD finger proteins	KMT2D KDM2A	8.52e-03	90	28	2	88
GeneFamily	PDZ domain containing	AHNAK RIMS2	2.30e-02	152	28	2	1220
ToppCell	control-Myeloid-CD14_Monocytes_2\|Myeloid / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	RPL23 RPL27 AHNAK ARL6IP5 SLFN11 GNS	3.61e-08	189	45	6	7f78b5bb8195f99b18082cbb612e9199b7a1538c
ToppCell	LPS_anti-TNF-Epithelial_alveolar-AT_2-AT2\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	FILIP1 HSDL2 DHRS4L1 SCP2 ALAS1	1.62e-06	197	45	5	ad6f047d003c08413264f39a30ba0f7639a257cd
ToppCell	facs-Kidney-nan-3m-Epithelial-epithelial_cell_of_proximal_tubule\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PRSS35 ACSM3 ACSM5 RIMS2	2.54e-05	169	45	4	922086f218135b734b7d370b871923e50141edce
ToppCell	facs-Kidney-nan-3m-Epithelial-epithelial_cell_of_proximal_tubule\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PRSS35 ACSM3 ACSM5 RIMS2	2.54e-05	169	45	4	ee27bcfe3f9a295ec5fb0a375d77d1050e5cbaad
ToppCell	mild_COVID-19_(asymptomatic)-Neutrophil\|World / disease group, cell group and cell class (v2)	HSDL2 CCDC146 ALAS1	4.09e-05	66	45	3	e71738a3a84be93053d1ed20d030e4c606f8f402
ToppCell	10x3'2.3-week_14-16-Hematopoietic-HSC/MPP_and_pro-ELP\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	GALNT2 MAP1A ARL6IP5 TOP2B	4.18e-05	192	45	4	38ec82aa2ec4f2c0a843e83f7fe54f6b2483ca3d
ToppCell	TCGA-Adrenal-Primary_Tumor-Adrenocortical_carcinoma-Usual_Type\|TCGA-Adrenal / Sample_Type by Project: Shred V9	ACADS HSDL2 DDX54 GNS	4.44e-05	195	45	4	c3280bb6219e2eff5e24ef45aa2d76479a562122
ToppCell	LPS_anti-TNF-Epithelial_alveolar-AT_2\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	FILIP1 HSDL2 DHRS4L1 ALAS1	4.62e-05	197	45	4	1638959d7aecb9fc5285eb7e4a3103ca437989e2
ToppCell	distal-Hematologic-Platelet/Megakaryocyte\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	MAP1A CCDC146 DHRS4L1 MYCBPAP	4.62e-05	197	45	4	e28b1b154d9588dce07c123b36f7f01fa90a5fc1
ToppCell	LPS_IL1RA-Epithelial_alveolar-AT_2-AT2\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	HSDL2 DHRS4L1 SCP2 ALAS1	4.71e-05	198	45	4	d12f37527399038a8f030b45b176bda5c7c8a7ad
ToppCell	critical-Epithelial-Ciliated\|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	FILIP1 MAP1A CCDC146 SLFN13	4.71e-05	198	45	4	ee2c8385c0bf4ea9f5c9517b52cf131af3fbdd40
ToppCell	18-Distal\|18 / Age, Tissue, Lineage and Cell class	RPL23 FILIP1 RPL27 PIEZO2	4.71e-05	198	45	4	d635398c6529c514e77c0dc9299e9cf00330c9e7
ToppCell	PBMC_fresh-frozen\|World / Compartment, severity and other cell annotations on 10x 3' data (130k)	RPL23 RPL27 AHNAK ARL6IP5	4.71e-05	198	45	4	dcc223a0396b8b673e4ed8c6733ec6cd74e9a03a
ToppCell	mild-Myeloid-CD16_Monocytes\|Myeloid / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	RPL23 RPL27 AHNAK ARL6IP5	4.71e-05	198	45	4	ba97ff6e9d400b53ad013dce54afd7154a0f4fc9
ToppCell	5'-GW_trimst-1.5-SmallIntestine-Mesenchymal-fibroblastic-Stromal_3_(C7+)\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PRSS35 PIEZO2 CCDC146 AHNAK	4.80e-05	199	45	4	83383d9ae4f501754fd3da0215ce6f0e3c70562c
ToppCell	LPS_IL1RA-Epithelial_alveolar\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	FILIP1 HSDL2 SCP2 ALAS1	4.80e-05	199	45	4	5b140ac88ebc25ce397ae577e48f3e271faf46e7
ToppCell	PCW_10-12-Mesenchymal-Mesenchymal_fibroblastic-mes_immature2_(2)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	RPL23 FILIP1 RPL27 PIEZO2	4.80e-05	199	45	4	d946db0e8cc3fbed2d0eb9b4346400138d43219f
ToppCell	severe-Myeloid-CD14_Monocytes_2\|Myeloid / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	RPL23 RPL27 AHNAK GNS	4.89e-05	200	45	4	2f1218c9884fabae952cdbff25b6baa7bae9e732
ToppCell	Posterior_cortex-Macroglia-ASTROCYTE-Gja1-Astrocyte.Gja1.Igfbp2_(Htra1)--\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	CCDC83 TAS2R3 ACSM5	9.03e-05	86	45	3	c1181a7e9f4cbde5a3bee7b54d6448dfce58b238
ToppCell	Posterior_cortex-Macroglia-ASTROCYTE-Gja1-Astrocyte.Gja1.Igfbp2_(Htra1)\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	CCDC83 TAS2R3 ACSM5	9.03e-05	86	45	3	4263673abf183f2e04f1a2bf37e365a25b8cb0b4
ToppCell	Posterior_cortex-Macroglia-ASTROCYTE-Gja1-Astrocyte.Gja1.Igfbp2_(Htra1)-\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	CCDC83 TAS2R3 ACSM5	9.03e-05	86	45	3	c6c0e8e562ffc705e0cd3f503a9e43ca2669e9b0
Computational	Genes in the cancer module 184.	ACADS ACSM5 ALDH9A1	6.15e-05	29	29	3	MODULE_184
Drug	butyraldehyde	OXCT1 ACADS OXCT2 ALDH9A1	2.66e-06	48	46	4	CID000000261
Drug	AC1L3UHX	OXCT1 OXCT2	3.99e-06	2	46	2	CID000095516
Drug	AC1NQZW7	OXCT1 OXCT2	3.99e-06	2	46	2	CID005282334
Drug	CPD-627	OXCT1 OXCT2	3.99e-06	2	46	2	CID000439367
Drug	AC1LCVNZ	OXCT1 OXCT2	3.99e-06	2	46	2	CID000656887
Drug	naphthyl-2-methyl-succinate	OXCT1 OXCT2	3.99e-06	2	46	2	CID000656886
Drug	AC1L9DYZ	OXCT1 ACADS OXCT2	4.24e-06	16	46	3	CID000443062
Drug	coproporphyrinogen I	OXCT1 OXCT2 ALAS1	6.17e-06	18	46	3	CID000440776
Drug	aminocarnitine	OXCT1 ACADS OXCT2	8.59e-06	20	46	3	CID000121830
Drug	N-acetylcysteamine	OXCT1 ACADS OXCT2	1.00e-05	21	46	3	CID000014484
Drug	4-PA	OXCT1 ACADS OXCT2	1.16e-05	22	46	3	CID000061138
Drug	AC1L19X5	OXCT1 ACADS OXCT2	1.16e-05	22	46	3	CID000000741
Drug	p-azidobenzoyl-CoA	OXCT1 OXCT2	1.20e-05	3	46	2	CID000194163
Drug	oxfenicine	OXCT1 ACADS OXCT2	1.33e-05	23	46	3	CID000036143
Drug	AC1L975Q	OXCT1 ACADS OXCT2	1.52e-05	24	46	3	CID000439337
Drug	AC1L2LUF	OXCT1 OXCT2	2.39e-05	4	46	2	CID000074406
Drug	C4:1n-2	OXCT1 ACADS OXCT2	2.44e-05	28	46	3	CID000019499
Drug	3HB-4HB	OXCT1 OXCT2	3.98e-05	5	46	2	CID003081116
Drug	AC1NS1NJ	OXCT1 OXCT2	3.98e-05	5	46	2	CID005327101
Drug	monoacetoacetin	OXCT1 OXCT2	3.98e-05	5	46	2	CID000125624
Drug	acrylyl-coenzyme A	OXCT1 ACADS OXCT2	5.71e-05	37	46	3	CID000439340
Drug	AC1NQZWS	OXCT1 OXCT2	5.96e-05	6	46	2	CID005282341
Drug	2-bromobutyrate	OXCT1 OXCT2	5.96e-05	6	46	2	CID000006655
Drug	AC1MRLG6	OXCT1 OXCT2	5.96e-05	6	46	2	CID003519889
Drug	AND-CoA	ACSM3 OXCT1 ACADS OXCT2	6.46e-05	107	46	4	CID003083159
Drug	methyl 3-mercaptopropionate	OXCT1 OXCT2	8.33e-05	7	46	2	CID000018050
Drug	crotonobetainyl-CoA	OXCT1 OXCT2	8.33e-05	7	46	2	CID000000591
Drug	carboxymuconolactone	OXCT1 OXCT2	8.33e-05	7	46	2	CID000000543
Drug	AC1L19VW	OXCT1 OXCT2	8.33e-05	7	46	2	CID000000726
Drug	AC1L1BTU	OXCT1 OXCT2	8.33e-05	7	46	2	CID000001603
Drug	gamma-butyrobetaine	OXCT1 OXCT2 ALDH9A1	8.38e-05	42	46	3	CID000000134
Drug	AC1L1GAZ	OXCT1 ACADS OXCT2	9.00e-05	43	46	3	CID000003605
Drug	AC1N3SS3	OXCT1 ACADS OXCT2	1.03e-04	45	46	3	CID000000592
Drug	2-naphthoic acid	OXCT1 OXCT2	1.11e-04	8	46	2	CID000007123
Drug	glutaconyl-CoA	OXCT1 OXCT2	1.11e-04	8	46	2	CID009543049
Drug	l-carnityl CoA	OXCT1 OXCT2	1.11e-04	8	46	2	CID000000605
Drug	AC1L9K5A	OXCT1 OXCT2	1.11e-04	8	46	2	CID000446832
Drug	chloranilic acid	OXCT2 ALAS1	1.11e-04	8	46	2	CID000066604
Drug	AC1Q68Z5	OXCT1 ACADS OXCT2 SCP2 ALAS1 ALDH9A1	1.21e-04	386	46	6	CID000000181
Drug	CPD-226	OXCT1 OXCT2	1.42e-04	9	46	2	CID000439705
Drug	U nu	SMC3 OXCT2 ALDH9A1	1.50e-04	51	46	3	CID000023943
Drug	AC1L195D	OXCT1 OXCT2	1.78e-04	10	46	2	CID000000399
Drug	AC1L99L3	OXCT1 OXCT2	1.78e-04	10	46	2	CID000440590
Drug	rhodoquinone	OXCT1 OXCT2	1.78e-04	10	46	2	CID006441300
Drug	carnitine	OXCT1 ACADS SMC3 OXCT2 ALDH9A1	1.91e-04	265	46	5	CID000000085
Drug	3-Hydroxybutanoyl-Coenzyme A	OXCT1 ACADS OXCT2	2.09e-04	57	46	3	CID000000521
Drug	pantetheine	OXCT1 ACADS OXCT2	2.09e-04	57	46	3	CID000000479
Drug	citramalate	OXCT1 OXCT2	2.17e-04	11	46	2	CID000001081
Drug	AC1L974K	OXCT1 OXCT2	2.17e-04	11	46	2	CID000439320
Drug	AC1L9896	OXCT1 OXCT2	2.17e-04	11	46	2	CID000439892
Drug	benzoyl-S-CoA	ACSM3 OXCT1 OXCT2	2.20e-04	58	46	3	CID000122174
Drug	enol-lactone	OXCT1 OXCT2	2.60e-04	12	46	2	CID000000104
Drug	AC1L19KJ	OXCT1 OXCT2	2.60e-04	12	46	2	CID000000589
Drug	AC1L99WA	OXCT1 OXCT2	2.60e-04	12	46	2	CID000440753
Drug	3-hydroxy-3-methylglutaric acid	OXCT1 OXCT2 GNS	2.82e-04	63	46	3	CID000001662
Drug	5-hydroxyvalerate	OXCT1 OXCT2	3.07e-04	13	46	2	CID000025945
Disease	acetoacetate measurement	OXCT1 GALNT2	5.78e-05	8	43	2	EFO_0010111
Disease	X-17676 measurement	ACSM3 ACSM5	5.78e-05	8	43	2	EFO_0800785
Disease	Myeloid Leukemia	SMC3 TOP2B	3.13e-04	18	43	2	C0023470
Disease	Leukemia, Monocytic, Chronic	SMC3 TOP2B	3.13e-04	18	43	2	C0023466
Disease	intrinsic cardiomyopathy (implicated_via_orthology)	CCT6A CCT6B	4.28e-04	21	43	2	DOID:0060036 (implicated_via_orthology)
Disease	3-hydroxybutyrate measurement	OXCT1 GALNT2	6.09e-04	25	43	2	EFO_0010982
Disease	myeloperoxidase measurement	SMG8 GALNT2	6.59e-04	26	43	2	EFO_0005243
Disease	Anemia, Diamond-Blackfan	RPL23 RPL27	8.79e-04	30	43	2	C1260899
Disease	clopidogrel metabolite measurement	SLFN13 CCT6B	1.06e-03	33	43	2	EFO_0007966

Protein segments in the cluster

Peptide	Gene	Start	Entry
TNLGPKGTMKMLVSG	CCT6A	36	P40227
KGTMKMLVSGAGDIK	CCT6A	41	P40227
TGMKIMEMSAKGIKP	ALDH9A1	236	P49189
VKKMGGLGLLAMDVP	ACADS	71	P16219
GKMKGTKVKTPEMII	AHNAK	481	Q09666
NPKGMKIKSGSMGKA	ACSM5	381	Q6NUN0
GPLGVKLMSVESKKM	CCDC83	366	Q8IWF9
GGMRPGKKVLVMGIV	LGALSL	46	Q3ZCW2
MSKGLVNGLKAGPMA	MAP1A	2666	P78559
GVMPKMDIISGTLGK	ALAS1	431	P13196
MIKAVVPEMEKRGGG	DHRS4L1	151	P0CG22
IKTPMIAGGLFVMDK	GALNT2	301	Q10471
MGLSYPVFKGIMKKG	DDX54	101	Q8TDD1
RGEKMKGKMVSQVPS	C9orf131	886	Q5VYM1
KAMKKDGLVGMAIVG	FIS1	116	Q9Y3D6
IKGKTTMPGMKRDCG	NPEPL1	271	Q8NDH3
SGKLKPTMAFMSGKL	HSDL2	381	Q6YN16
PTMAFMSGKLKIKGN	HSDL2	386	Q6YN16
GAMLGLKVVGGKMTE	RIMS2	676	Q9UQ26
GVGDMVMATVKKGKP	RPL23	56	P62829
MKKFGGPGRMKQSCV	KDM2A	591	Q9Y2K7
PLKKTKALIGEMGMT	GNS	66	P15586
LKKNGGIVMVTLSMG	DPEP3	311	Q9H4B8
MGKFMKPGKVVLVLA	RPL27	1	P61353
PGSGKTIMAMKIMEK	SLFN13	601	Q68D06
KVMKVMGSGPKESAL	SMG8	866	Q8ND04
LFLKKMGAKGSTPGM	TRIM32	356	Q13049
TNLGPKGTMKMLVSG	CCT6B	36	Q92526
KGTMKMLVSGAGDIK	CCT6B	41	Q92526
KLVPGGKATLVMKKG	SMC3	1046	Q9UQE7
MSGKAIKGKVGKPKV	TOP2B	1211	Q02880
GNFLPKTKMAKMIGE	TAS2R3	256	Q9NYW6
PMSKGMKAGKPVVAA	FILIP1	1161	Q7Z7B0
RSILLVGPSGMGKKM	IQCA1L	561	A6NCM1
VGPSGMGKKMLVKAV	IQCA1L	566	A6NCM1
KMEGIGLKRTPMGIV	ARL6IP5	151	O75915
PGSGKTIMAMKIMEK	SLFN11	601	Q7Z7L1
PGKMVKGMGGAMDLV	OXCT1	416	P55809
GKLKITGNMGLAMKL	SCP2	521	P22307
MIPGKKVKGMGGAMD	OXCT2	411	Q9BYC2
IMKNPKAKTTGMGAI	SGPL1	511	O95470
MGKLPGTRMAALKAK	CCDC146	56	Q8IYE0
GNFKGMKIKPGSMGK	ACSM3	386	Q53FZ2
QKIMTKMGYIPGKGL	ERVK-24	116	P63129
QKIMTKMGYIPGKGL	HERVK_113	116	P63121
MELGISPTIKKMPGG	PRSS35	291	Q8N3Z0
QKIMTKMGYIPGKGL	ERVK-7	116	P63131
KKKVVKYGMGGMIIV	PIEZO2	2396	Q9H5I5
QKIMTKMGYIPGKGL	ERVK-6	116	Q9Y6I0
QKIMTKMGYIPGKGL	ERVK-25	116	P63125
MVPGGTMKSLKKDSR	MYCBPAP	1	Q8TBZ2
QKIMTKMGYIPGKGL	ERVK-10	116	P10265
PAGMSAKMLGGVFKI	YTHDC1	431	Q96MU7
QKIMTKMGYIPGKGL	ERVK-18	116	P63123
LSPLMMAAKTGKIGI	TRPV4	371	Q9HBA0
QKIMTKMGYIPGKGL	ERVK-21	116	P63119
PKMKTKSGPVMGGGL	YTHDF1	246	Q9BYJ9
QKIMTKMGYIPGKGL	HERV-K104	116	P63124
QKIMTKMGYILGKGL	ERVK-19	116	P63120
KKVMAQGSIGVAPGM	KMT2D	3436	O14686