Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionHsp70 protein binding

DNAJB6 DNAJB8 DNAJB2 DNAJB3

1.50e-0663274GO:0030544
GeneOntologyMolecularFunctionprotein-folding chaperone binding

DNAJB6 DNAJB8 DNAJB2 DNAJC3 DNAJB3

2.24e-06161275GO:0051087
GeneOntologyMolecularFunctionunfolded protein binding

DNAJB6 DNAJB8 DNAJB2 DNAJB3

2.37e-05126274GO:0051082
GeneOntologyMolecularFunctionheat shock protein binding

DNAJB6 DNAJB8 DNAJB2 DNAJB3

6.49e-05163274GO:0031072
GeneOntologyMolecularFunctionprotein folding chaperone

DNAJB6 DNAJB8 DNAJB3

1.29e-0473273GO:0044183
GeneOntologyMolecularFunctionATPase activator activity

DNAJB6 DNAJB2

8.52e-0432272GO:0001671
GeneOntologyMolecularFunctionATPase regulator activity

DNAJB6 DNAJB2

2.41e-0354272GO:0060590
GeneOntologyBiologicalProcessnegative regulation of inclusion body assembly

DNAJB6 DNAJB8 DNAJB2

3.88e-0712263GO:0090084
GeneOntologyBiologicalProcessprotein folding

DNAJB6 DNAJC21 DNAJB8 DNAJB2 DNAJC3 DNAJB3

5.10e-07246266GO:0006457
GeneOntologyBiologicalProcessregulation of inclusion body assembly

DNAJB6 DNAJB8 DNAJB2

2.33e-0621263GO:0090083
GeneOntologyBiologicalProcesschaperone-mediated protein folding

DNAJB6 DNAJB8 DNAJB2 DNAJB3

2.94e-0680264GO:0061077
GeneOntologyBiologicalProcessinclusion body assembly

DNAJB6 DNAJB8 DNAJB2

9.46e-0633263GO:0070841
GeneOntologyBiologicalProcessprotein maturation

DNAJB6 DNAJC21 DNAJB8 DNAJB2 DNAJC3 DNAJB3

9.83e-05619266GO:0051604
DomainDnaJ

DNAJB6 DNAJC21 DNAJB8 DNAJB2 DNAJC3 DNAJB3

5.92e-1148276PF00226
DomainDnaJ

DNAJB6 DNAJC21 DNAJB8 DNAJB2 DNAJC3 DNAJB3

6.74e-1149276SM00271
DomainDNAJ_1

DNAJB6 DNAJC21 DNAJB8 DNAJB2 DNAJC3 DNAJB3

6.74e-1149276PS00636
DomainDNAJ_2

DNAJB6 DNAJC21 DNAJB8 DNAJB2 DNAJC3 DNAJB3

6.74e-1149276PS50076
Domain-

DNAJB6 DNAJC21 DNAJB8 DNAJB2 DNAJC3 DNAJB3

6.74e-11492761.10.287.110
DomainDnaJ_domain

DNAJB6 DNAJC21 DNAJB8 DNAJB2 DNAJC3 DNAJB3

8.67e-1151276IPR001623
DomainDnaJ_domain_CS

DNAJB6 DNAJC21 DNAJB8 DNAJB2 DNAJB3

3.37e-1027275IPR018253
DomainTPR_8

TTC17 DNAJC3

2.65e-0353272PF13181
DomainIGv

ERMAP DSCAML1

5.23e-0375272SM00406
DomainTPR_1

TTC17 DNAJC3

7.45e-0390272PF00515
DomainTPR_1

TTC17 DNAJC3

7.45e-0390272IPR001440
Pubmed

Mammalian HSP40/DNAJ homologs: cloning of novel cDNAs and a proposal for their classification and nomenclature.

DNAJB6 DNAJB8 DNAJB2 DNAJC3

2.09e-092227411147971
Pubmed

NSUN4 is a dual function mitochondrial protein required for both methylation of 12S rRNA and coordination of mitoribosomal assembly.

TMEM163 NSUN4

5.80e-07227224516400
Pubmed

Molecular cloning, structure, and testis-specific expression of MFSJ1, a member of the DNAJ protein family, in the Japanese monkey (Macaca fuscata).

DNAJB6 DNAJB3

5.80e-07227212565881
Pubmed

The DNAJB6 and DNAJB8 protein chaperones prevent intracellular aggregation of polyglutamine peptides.

DNAJB6 DNAJB8

5.80e-07227223612975
Pubmed

Structure of msj-1 gene in mice and humans: a possible role in the regulation of male reproduction.

DNAJB6 DNAJB3

5.80e-07227218184612
Pubmed

The diverse members of the mammalian HSP70 machine show distinct chaperone-like activities.

DNAJB6 DNAJB8 DNAJB2

7.31e-072327321231916
Pubmed

Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.

DNAJB6 DNAJC21 TTC17 DNAJB8 DNAJB2 DNAJC3 DNAJB3 MTIF2 CASK

1.09e-06148727933957083
Pubmed

Versatile members of the DNAJ family show Hsp70 dependent anti-aggregation activity on RING1 mutant parkin C289G.

DNAJB6 DNAJB8

1.74e-06327227713507
Pubmed

Molecular chaperone-mediated rescue of mitophagy by a Parkin RING1 domain mutant.

DNAJB6 DNAJB2

1.74e-06327220889486
Pubmed

The deubiquitinating enzyme mUBPy interacts with the sperm-specific molecular chaperone MSJ-1: the relation with the proteasome, acrosome, and centrosome in mouse male germ cells.

DNAJB6 DNAJB3

1.74e-06327215342353
Pubmed

Evolution of an intricate J-protein network driving protein disaggregation in eukaryotes.

DNAJB8 DNAJB2

5.80e-06527228504929
Pubmed

K48- and K63-linked ubiquitin chain interactome reveals branch- and length-specific ubiquitin interactors.

NSUN4 ANKZF1 DNAJB2 DNAJC3 NDUFB9 CASK

5.81e-0660427638803224
Pubmed

A DNAJB chaperone subfamily with HDAC-dependent activities suppresses toxic protein aggregation.

DNAJB6 DNAJB8

8.69e-06627220159555
Pubmed

P62/SQSTM1 is a novel leucine-rich repeat kinase 2 (LRRK2) substrate that enhances neuronal toxicity.

DNAJB6 DNAJB8

3.81e-051227229519959
InteractionGRPEL1 interactions

DNAJB6 DNAJC21 DNAJB8 DNAJB2 DNAJC3 DNAJB3 MTIF2

6.71e-09210267int:GRPEL1
InteractionATP5PD interactions

DNAJB6 DNAJC21 BRD1 DNAJB3 NDUFB9 MTIF2

1.68e-06295266int:ATP5PD
InteractionDNAJB6 interactions

DNAJB6 DNAJC21 DNAJB8 BRD1 DNAJB2 DNAJC3

7.12e-06379266int:DNAJB6
InteractionHSPA1L interactions

DNAJB6 DNAJB8 DNAJB2 DNAJC3 NDUFB9

3.01e-05289265int:HSPA1L
InteractionUSP34 interactions

ERMAP DNAJB8 BRD1 DNAJB2

4.64e-05157264int:USP34
InteractionFKBP8 interactions

DNAJB6 TTC17 DNAJB8 BRD1 DNAJB2 DNAJC3

5.14e-05538266int:FKBP8
InteractionTMEM231 interactions

DNAJB2 DNAJC3 DNAJB3

1.16e-0474263int:TMEM231
InteractionANKEF1 interactions

NXN JMJD6

1.44e-0414262int:ANKEF1
InteractionDNAJB8 interactions

DNAJB6 DNAJB8 DNAJB2

1.47e-0480263int:DNAJB8
InteractionDNAJC7 interactions

DNAJB6 DNAJB8 DNAJB2 DNAJC3 DNAJB3

1.86e-04425265int:DNAJC7
CytobandEnsembl 112 genes in cytogenetic band chr2q35

ANKZF1 DNAJB2

2.63e-03129272chr2q35
GeneFamilyDNAJ (HSP40) heat shock proteins|C2 tensin-type domain containing

DNAJB6 DNAJC21 DNAJB8 DNAJB2 DNAJC3 DNAJB3

1.09e-1149206584
GeneFamilyTetratricopeptide repeat domain containing|Bardet-Biedl syndrome associated|BBSome

TTC17 DNAJC3

7.07e-03115202769
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD|renal_cortex_nuclei / Celltypes from Cells and Nuclei per compartment and clinical group

GLYATL1 NXN TMEM132D DSCAML1

4.14e-06181274c80ffa2ded5975a88e9a1a7d333196f95237bf0a
ToppCell(01)_Cycling_Basal_(homeostasis)-(3)_72hpi|(01)_Cycling_Basal_(homeostasis) / shred by cell type and Timepoint

NSUN4 SAMD4A

1.30e-0428272ef8053df22b28c772eb39c5e4033f96eb5aa54d9
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Degenerative_Descending_Thin_Limb_Cell_Type_3|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

TMEM163 TMEM132D DSCAML1

1.30e-041642731cb5fbd7050650047ad6f2ca792118e98d58d22b
ToppCellfacs-Marrow-B-cells-18m-Hematologic-megakaryocyte-erythroid_progenitor_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ERMAP DNAJB2 SAMD4A

1.40e-0416827317fb9426eeea407b26fb895b8397faca95b7552d
ToppCellfacs-Marrow-B-cells-24m-Hematologic-megakaryocyte-erythroid_progenitor_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ERMAP DNAJB2 DNAJB3

1.40e-0416827308fe8fa43c343c03f9a2f0b982192fde04a7c027
ToppCellfacs-Marrow-B-cells-24m-Hematologic-megakaryocyte-erythroid_progenitor_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ERMAP DNAJB2 DNAJB3

1.40e-04168273d4053b2fffb19e0376b8ceb92e87ec4447d96a3e
ToppCellCOVID-19-kidney-PEC|COVID-19 / Disease (COVID-19 only), tissue and cell type

TMEM163 TMEM132D DSCAML1

1.40e-04168273a086c306be430adf0632ba53e98cd8014d2de330
ToppCellfacs-Marrow-B-cells-18m-Hematologic-megakaryocyte-erythroid_progenitor_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ERMAP DNAJB2 SAMD4A

1.40e-04168273a61b39884851384cffd430079040546d125b2b40
ToppCellControl-Epithelial_cells-AT1|Control / group, cell type (main and fine annotations)

NXN TMEM132D SAMD4A

1.55e-04174273548d7f2b958a2bfd2c95eb049ceaab55a559c77d
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

TMEM163 TMEM132D DSCAML1

1.61e-04176273327a3e81b724252e36d786de92a3ffd721ea6d7b
ToppCellAT1_cells-HP_01|World / lung cells shred on cell class, cell subclass, sample id

NXN TMEM132D SAMD4A

1.61e-04176273458720776b0151cd55acc352d509599cb62f0ca8
ToppCellPCW_05-06-Epithelial-Epithelial_neuroendo-epi_neuroendocrine2[NE2]_(12)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

TMEM163 ST8SIA3 TMEM132D

1.77e-04182273dc29e8735c3562ce32322351d28f7d9709208ebf
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_2|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

TMEM163 TMEM132D DSCAML1

1.77e-041822735e1b316599436740f1b30875f0ebd33c3edfb2b6
ToppCell3'-Parenchyma_lung-Epithelial-Neuro-endocrine/ionocytic|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

GLYATL1 ST8SIA3 TMEM132D

1.83e-04184273d5e44c9085da2a46531ed6db1249bdd88c41b45c
ToppCell3'-Parenchyma_lung-Epithelial-Neuro-endocrine/ionocytic-lung_neuroendocrine_cell-Neuroendocrine-Neuroendocrine_L.0.7.2.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

GLYATL1 ST8SIA3 TMEM132D

1.86e-04185273a34663974868e267495240c0d5c06e390f57b08b
ToppCell3'-Parenchyma_lung-Epithelial-Neuro-endocrine/ionocytic-lung_neuroendocrine_cell-Neuroendocrine|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

GLYATL1 ST8SIA3 TMEM132D

1.86e-04185273b52e6adfecac93210c27c1d321a5951d54846c40
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

TMEM163 NXN TMEM132D

1.86e-0418527334fcfd635c828dad9643bbf1c908d79282d6f5d9
ToppCell3'-Parenchyma_lung-Epithelial-Neuro-endocrine/ionocytic-lung_neuroendocrine_cell|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

GLYATL1 ST8SIA3 TMEM132D

1.86e-04185273522030941687a268ec2520248df1817b57744a19
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell-Parietal_Epithelial_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

TMEM163 NXN TMEM132D

1.86e-041852738816f2909ed11833ff3d0ed96b9cb6d6fe9e1578
ToppCellPCW_07-8.5-Epithelial-Epithelial_neuroendo-epi_neuroendocrine2[NE2]_(12)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

TMEM163 ST8SIA3 TMEM132D

1.89e-04186273c7983281a290201567b398e9ea6baddb96c692bb
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

TMEM163 TMEM132D DSCAML1

1.95e-0418827363a4b25a0a6e05f80f1a6dd91b817f3cf49e6b68
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

DSCAML1 SAMD4A CASK

1.98e-041892735d902a4660a27548764bf04c6de152b565da835c
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

DSCAML1 SAMD4A CASK

1.98e-041892738c8ca3b30d9be6c854615459a7bfba82b427c8bc
ToppCelldroplet-Marrow-nan-3m-Hematologic-erythroblast|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ERMAP DNAJB2 SAMD4A

1.98e-041892738a38baee58a27c2fa3f4bd131ab9f15723ed9295
ToppCellPCW_10-12-Epithelial-Epithelial_neuroendo|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

TMEM163 ST8SIA3 TMEM132D

2.01e-041902732375e604eacd38f61f3e661ba2f76d286fcceca7
ToppCellPCW_07-8.5-Epithelial-Epithelial_neuroendo-epi_neuroendocrine1[NE1]_(11)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

TMEM163 ST8SIA3 TMEM132D

2.01e-04190273b1095b2a7467c152d16e4f19a9515aeb61fc9e3d
ToppCellPCW_10-12-Epithelial-Epithelial_neuroendo-epi_neuroendocrine2[NE2]_(12)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

TMEM163 ST8SIA3 TMEM132D

2.08e-041922734d3a1c267739b1479217144656986972fc86db43
ToppCellIPF-Epithelial-Club|Epithelial / Disease state, Lineage and Cell class

TMEM163 NXN SAMD4A

2.08e-04192273356e7a820b744a0ac87352a8d0e6e8d9fa9ed7d2
ToppCellPCW_10-12-Mesenchymal-Mesenchymal_fibroblastic-mes_immature4_(1)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

DNAJB6 JMJD6 SAMD4A

2.11e-04193273dbf0fe496254320c894568c31e5f9ce63707d1b5
ToppCellPCW_13-14-Epithelial-Epithelial_neuroendo|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

TMEM163 ST8SIA3 TMEM132D

2.11e-041932738603d1a38955ad2529d04e4704467c73ea5bfbda
ToppCellCOVID-19_Mild|World / Disease condition and Cell class

DNAJB6 BRD1 JMJD6

2.11e-041932737256a5a491536c525b31ae96d47ab5c6303cb73a
ToppCellPCW_07-8.5-Epithelial-Epithelial_neuroendo|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

TMEM163 ST8SIA3 TMEM132D

2.14e-04194273b30379f8dc41c86c746af9930541fbb4819d8fa0
ToppCellBrain_organoid-organoid_Tanaka_cellReport-1m-Mesenchymal-Unfolded_protein_responsible_cell|1m / Sample Type, Dataset, Time_group, and Cell type.

DNAJB2 JMJD6 DNAJC3

2.34e-042002737cd66af5427f9850a8200686201ca18f35a2a025
ToppCellBrain_organoid-organoid_Tanaka_cellReport-3m-Mesenchymal-Unfolded_protein_responsible_cell|3m / Sample Type, Dataset, Time_group, and Cell type.

DNAJB2 JMJD6 DNAJC3

2.34e-04200273e68e44ab57d17ac4845d9e3798814d048d79e888
ToppCellMacroglial-Polydendrocytes-PDGFRA----L1-6|Macroglial / cells hierarchy compared to all cells using T-Statistic

TMEM163 TMEM132D CASK

2.34e-04200273310cd53db1c137f6af74e6ae682221d7ac27310c
ToppCellMacroglial-Polydendrocytes-PDGFRA|Macroglial / cells hierarchy compared to all cells using T-Statistic

TMEM163 TMEM132D CASK

2.34e-04200273c24a3099e3d96d8b72f6d05286bb355d661a0377
ToppCellMacroglial-Polydendrocytes-PDGFRA---|Macroglial / cells hierarchy compared to all cells using T-Statistic

TMEM163 TMEM132D CASK

2.34e-042002734fc3de4bff7ed2bf40b38462c4b4e9b87af6a4ca
ToppCellMacroglial-Polydendrocytes-PDGFRA-|Macroglial / cells hierarchy compared to all cells using T-Statistic

TMEM163 TMEM132D CASK

2.34e-04200273f17b5a54e8f9eba9dcd0808ba4e8d275ac41bce2
ToppCellMacroglial-Polydendrocytes-PDGFRA--|Macroglial / cells hierarchy compared to all cells using T-Statistic

TMEM163 TMEM132D CASK

2.34e-04200273cc3409518f8b436ea92deb955e81114b3f410ff7
ToppCellMacroglial-Polydendrocytes|Macroglial / cells hierarchy compared to all cells using T-Statistic

TMEM163 TMEM132D CASK

2.34e-04200273961858738ce35db8760c8c2e136f8369bc444ccf
DiseaseHuntington's disease (implicated_via_orthology)

DNAJB6 DNAJB8 DNAJB2 DNAJB3

1.96e-0832274DOID:12858 (implicated_via_orthology)
Diseaseautism spectrum disorder (implicated_via_orthology)

DSCAML1 CASK

8.50e-03152272DOID:0060041 (implicated_via_orthology)

Protein segments in the cluster

PeptideGeneStartEntry
KAAKEKLKYWQRLRH

BRD1

516

O95696
KAYRKLALRWHPDKN

DNAJB8

21

Q8NHS0
IKAYRKLALQWHPDN

DNAJC3

411

Q13217
LNHPWLKERDRYAYK

CASK

271

O14936
PKLSRKWYRILKQEH

JMJD6

306

Q6NYC1
KAREKYGHLLWKKRS

MTIF2

476

P46199
MARPLKQWLYKHRDN

MKX

81

Q8IYA7
WKRGKNERSLHYIKR

GLYATL1

186

Q969I3
WFQNHRYKLKRARAP

NKX2-8

131

O15522
KAYRKLALKWHPDKN

DNAJC21

21

Q5F1R6
VPRRHRYKKKWAATE

NSUN4

21

Q96CB9
KAYRKLALKWHPDKN

DNAJB6

21

O75190
VAKPKHKRTDYRRWK

DACT1

666

Q9NYF0
YKLDWHRFNLKQRLK

ANKZF1

91

Q9H8Y5
KAYRKLALKWHPDKN

DNAJB3

21

Q8WWF6
IKWYKDALLLPDNHR

DSCAML1

536

Q8TD84
KAYRRKALQWHPDKN

DNAJB2

21

P25686
LYHKLCLHWRLSKRK

CHIC2

126

Q9UKJ5
IWKQRRAKEKLLYEH

ERMAP

176

Q96PL5
NWKLKAHILRDKVYL

TMEM132D

126

Q14C87
ALPYKEKHRKLKLWN

NXN

111

Q6DKJ4
PDYFAKREQWKKLRR

NDUFB9

116

Q9Y6M9
NRYWKNKHLSPKRLS

ST8SIA3

286

O43173
RDIYLKKHKLLPNDW

PXYLP1

181

Q8TE99
AYRDKQHILWPKRAD

TTC17

491

Q96AE7
LKPHEAQNYRKKALW

TMEM163

76

Q8TC26
KDVPAWLKSLRLHKY

SAMD4A

326

Q9UPU9