Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	cysteine-type deubiquitinase activity	CYLD USP9X USP9Y USP20	1.90e-04	114	50	4	GO:0004843
GeneOntologyMolecularFunction	deubiquitinase activity	CYLD USP9X USP9Y USP20	2.62e-04	124	50	4	GO:0101005
GeneOntologyMolecularFunction	ubiquitin-like protein peptidase activity	CYLD USP9X USP9Y USP20	3.82e-04	137	50	4	GO:0019783
GeneOntologyMolecularFunction	co-SMAD binding	USP9X USP9Y	3.99e-04	12	50	2	GO:0070410
GeneOntologyMolecularFunction	K63-linked deubiquitinase activity	CYLD USP9X	7.21e-04	16	50	2	GO:0061578
GeneOntologyMolecularFunction	K48-linked deubiquitinase activity	CYLD USP9X	1.25e-03	21	50	2	GO:1990380
GeneOntologyMolecularFunction	cysteine-type peptidase activity	CYLD USP9X USP9Y USP20	1.35e-03	192	50	4	GO:0008234
GeneOntologyMolecularFunction	mRNA 3'-UTR AU-rich region binding	EXOSC8 EXOSC7	2.39e-03	29	50	2	GO:0035925
GeneOntologyBiologicalProcess	U1 snRNA 3'-end processing	EXOSC8 EXOSC7	1.80e-05	3	51	2	GO:0034473
GeneOntologyBiologicalProcess	U5 snRNA 3'-end processing	EXOSC8 EXOSC7	1.80e-05	3	51	2	GO:0034476
GeneOntologyBiologicalProcess	protein K63-linked deubiquitination	CYLD USP9X USP20	6.72e-05	32	51	3	GO:0070536
GeneOntologyBiologicalProcess	nuclear polyadenylation-dependent rRNA catabolic process	EXOSC8 EXOSC7	1.25e-04	7	51	2	GO:0071035
GeneOntologyBiologicalProcess	TRAMP-dependent tRNA surveillance pathway	EXOSC8 EXOSC7	1.25e-04	7	51	2	GO:0071038
GeneOntologyBiologicalProcess	U4 snRNA 3'-end processing	EXOSC8 EXOSC7	1.66e-04	8	51	2	GO:0034475
GeneOntologyBiologicalProcess	tRNA surveillance	EXOSC8 EXOSC7	1.66e-04	8	51	2	GO:0106354
GeneOntologyBiologicalProcess	exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	EXOSC8 EXOSC7	2.13e-04	9	51	2	GO:0000467
GeneOntologyBiologicalProcess	protein deubiquitination	CYLD USP9X USP9Y USP20	2.58e-04	125	51	4	GO:0016579
GeneOntologyBiologicalProcess	rRNA 3'-end processing	EXOSC8 EXOSC7	2.66e-04	10	51	2	GO:0031125
GeneOntologyBiologicalProcess	nuclear mRNA surveillance	EXOSC8 EXOSC7	3.25e-04	11	51	2	GO:0071028
GeneOntologyBiologicalProcess	snRNA metabolic process	EXOSC8 ICE1 EXOSC7	4.20e-04	59	51	3	GO:0016073
GeneOntologyBiologicalProcess	protein modification by small protein removal	CYLD USP9X USP9Y USP20	4.41e-04	144	51	4	GO:0070646
GeneOntologyCellularComponent	nucleolar exosome (RNase complex)	EXOSC8 EXOSC7	2.80e-04	10	53	2	GO:0101019
GeneOntologyCellularComponent	cytoplasmic exosome (RNase complex)	EXOSC8 EXOSC7	7.40e-04	16	53	2	GO:0000177
GeneOntologyCellularComponent	nuclear exosome (RNase complex)	EXOSC8 EXOSC7	7.40e-04	16	53	2	GO:0000176
GeneOntologyCellularComponent	exosome (RNase complex)	EXOSC8 EXOSC7	1.68e-03	24	53	2	GO:0000178
GeneOntologyCellularComponent	exoribonuclease complex	EXOSC8 EXOSC7	2.13e-03	27	53	2	GO:1905354
Domain	USP_CS	CYLD USP9X USP9Y USP20	2.67e-05	66	49	4	IPR018200
Domain	USP_1	CYLD USP9X USP9Y USP20	3.38e-05	70	49	4	PS00972
Domain	UCH	CYLD USP9X USP9Y USP20	3.57e-05	71	49	4	PF00443
Domain	USP_2	CYLD USP9X USP9Y USP20	3.57e-05	71	49	4	PS00973
Domain	USP_3	CYLD USP9X USP9Y USP20	3.77e-05	72	49	4	PS50235
Domain	USP_dom	CYLD USP9X USP9Y USP20	3.77e-05	72	49	4	IPR028889
Domain	Peptidase_C19_UCH	CYLD USP9X USP9Y USP20	3.77e-05	72	49	4	IPR001394
Domain	RNase_PH_C	EXOSC8 EXOSC7	1.00e-04	6	49	2	PF03725
Domain	-	EXOSC8 EXOSC7	1.00e-04	6	49	2	3.30.230.70
Domain	PNPase/RNase_PH_dom	EXOSC8 EXOSC7	1.00e-04	6	49	2	IPR027408
Domain	ExoRNase_PH_dom2	EXOSC8 EXOSC7	1.40e-04	7	49	2	IPR015847
Domain	RNase_PH	EXOSC8 EXOSC7	1.40e-04	7	49	2	PF01138
Domain	ExoRNase_PH_dom1	EXOSC8 EXOSC7	2.99e-04	10	49	2	IPR001247
Domain	hEGF	EYS SLIT1	2.44e-03	28	49	2	PF12661
Domain	Ribosomal_S5_D2-typ_fold	EXOSC8 EXOSC7	3.59e-03	34	49	2	IPR020568
Domain	LAM_G_DOMAIN	EYS SLIT1	4.46e-03	38	49	2	PS50025
Domain	Laminin_G_2	EYS SLIT1	4.94e-03	40	49	2	PF02210
Domain	LamG	EYS SLIT1	5.95e-03	44	49	2	SM00282
Pathway	REACTOME_KSRP_KHSRP_BINDS_AND_DESTABILIZES_MRNA	EXOSC8 EXOSC7	5.81e-04	15	34	2	MM15141
Pathway	REACTOME_MRNA_DECAY_BY_3_TO_5_EXORIBONUCLEASE	EXOSC8 EXOSC7	6.63e-04	16	34	2	MM15091
Pathway	REACTOME_MRNA_DECAY_BY_3_TO_5_EXORIBONUCLEASE	EXOSC8 EXOSC7	6.63e-04	16	34	2	M19582
Pathway	REACTOME_BUTYRATE_RESPONSE_FACTOR_1_BRF1_BINDS_AND_DESTABILIZES_MRNA	EXOSC8 EXOSC7	7.51e-04	17	34	2	M934
Pathway	REACTOME_TRISTETRAPROLIN_TTP_ZFP36_BINDS_AND_DESTABILIZES_MRNA	EXOSC8 EXOSC7	7.51e-04	17	34	2	M964
Pathway	REACTOME_BUTYRATE_RESPONSE_FACTOR_1_BRF1_BINDS_AND_DESTABILIZES_MRNA	EXOSC8 EXOSC7	7.51e-04	17	34	2	MM15136
Pathway	REACTOME_TRISTETRAPROLIN_TTP_ZFP36_BINDS_AND_DESTABILIZES_MRNA	EXOSC8 EXOSC7	7.51e-04	17	34	2	MM15138
Pathway	REACTOME_KSRP_KHSRP_BINDS_AND_DESTABILIZES_MRNA	EXOSC8 EXOSC7	7.51e-04	17	34	2	M959
Pubmed	The Drosophila developmental gene fat facets has a human homologue in Xp11.4 which escapes X-inactivation and has related sequences on Yq11.2.	USP9X USP9Y	2.28e-06	2	53	2	8922996
Pubmed	Usp9y (ubiquitin-specific protease 9 gene on the Y) is associated with a functional promoter and encodes an intact open reading frame homologous to Usp9x that is under selective constraint.	USP9X USP9Y	2.28e-06	2	53	2	12925892
Pubmed	Ubiquitin-specific protease activity of USP9Y, a male infertility gene on the Y chromosome.	USP9X USP9Y	2.28e-06	2	53	2	12895410
Pubmed	Structure of an Rrp6-RNA exosome complex bound to poly(A) RNA.	EXOSC8 EXOSC7	3.40e-05	6	53	2	25043052
Pubmed	A HECT domain E3 enzyme assembles novel polyubiquitin chains.	UBR1 USP9X	6.34e-05	8	53	2	11278995
Pubmed	Structure of a Cytoplasmic 11-Subunit RNA Exosome Complex.	EXOSC8 EXOSC7	8.15e-05	9	53	2	27345150
Pubmed	Mpp6 Incorporation in the Nuclear Exosome Contributes to RNA Channeling through the Mtr4 Helicase.	EXOSC8 EXOSC7	1.02e-04	10	53	2	28877463
Pubmed	Low expression of EXOSC2 protects against clinical COVID-19 and impedes SARS-CoV-2 replication.	EXOSC8 EXOSC7	1.02e-04	10	53	2	36241425
Pubmed	Characterisation of the coding sequence and fine mapping of the human DFFRY gene and comparative expression analysis and mapping to the Sxrb interval of the mouse Y chromosome of the Dffry gene.	USP9X USP9Y	1.02e-04	10	53	2	9384609
Pubmed	Reconstitution, activities, and structure of the eukaryotic RNA exosome.	EXOSC8 EXOSC7	1.24e-04	11	53	2	17174896
Pubmed	The association of the human PM/Scl-75 autoantigen with the exosome is dependent on a newly identified N terminus.	EXOSC8 EXOSC7	1.24e-04	11	53	2	12788944
Pubmed	Protein-protein interactions between human exosome components support the assembly of RNase PH-type subunits into a six-membered PNPase-like ring.	EXOSC8 EXOSC7	1.49e-04	12	53	2	12419256
Pubmed	Loss of Usp9x disrupts cortical architecture, hippocampal development and TGFβ-mediated axonogenesis.	USP9X USP9Y	1.49e-04	12	53	2	23861879
Pubmed	Protein-protein interactions of hCsl4p with other human exosome subunits.	EXOSC8 EXOSC7	1.76e-04	13	53	2	11812149
Pubmed	Dis3-like 1: a novel exoribonuclease associated with the human exosome.	EXOSC8 EXOSC7	1.76e-04	13	53	2	20531389
Pubmed	The RNA exosome targets the AID cytidine deaminase to both strands of transcribed duplex DNA substrates.	EXOSC8 EXOSC7	1.76e-04	13	53	2	21255825
Pubmed	Deubiquitinating enzymes: a new class of biological regulators.	USP9X USP9Y	2.36e-04	15	53	2	9827704
Pubmed	Evolutionary strata on the mouse X chromosome correspond to strata on the human X chromosome.	USP9X USP9Y	2.36e-04	15	53	2	14762062
Pubmed	Protein Phosphatase 1 Subunit PPP1R14B Stabilizes STMN1 to Promote Progression and Paclitaxel Resistance in Triple-Negative Breast Cancer.	USP9X PPP1R14B	2.70e-04	16	53	2	36484700
Pubmed	Systematic Affinity Purification Coupled to Mass Spectrometry Identified p62 as Part of the Cannabinoid Receptor CB2 Interactome.	UBR1 TMEM259 USP9X	2.92e-04	84	53	3	31616248
Pubmed	A strategy for modulation of enzymes in the ubiquitin system.	USP9X USP9Y	3.05e-04	17	53	2	23287719
Pubmed	Exosome complex components 1 and 2 are vital for early mammalian development.	EXOSC8 EXOSC7	3.43e-04	18	53	2	37940010
Pubmed	AU binding proteins recruit the exosome to degrade ARE-containing mRNAs.	EXOSC8 EXOSC7	3.43e-04	18	53	2	11719186
Pubmed	The human core exosome interacts with differentially localized processive RNases: hDIS3 and hDIS3L.	EXOSC8 EXOSC7	3.43e-04	18	53	2	20531386
Pubmed	Sex differences in sex chromosome gene expression in mouse brain.	USP9X USP9Y	3.43e-04	18	53	2	12023983
Pubmed	Usp12 stabilizes the T-cell receptor complex at the cell surface during signaling.	CYLD USP9X	5.16e-04	22	53	2	26811477
Pubmed	Post-transcriptional regulation by the exosome complex is required for cell survival and forebrain development via repression of P53 signaling.	EXOSC8 EXOSC7	7.80e-04	27	53	2	33462115
Pubmed	14-3-3 cooperates with LKB1 to regulate the activity and localization of QSK and SIK.	CDC37 USP9X	9.64e-04	30	53	2	16306228
Pubmed	Interpreting cancer genomes using systematic host network perturbations by tumour virus proteins.	FZD6 TMEM259 FARS2 FAM200A ZNF417	9.70e-04	499	53	5	22810586
Pubmed	Molecular architecture of the developing mouse brain.	TRHR PTPRZ1 SLIT1	1.09e-03	132	53	3	34321664
Pubmed	OTUD6A Is an Aurora Kinase A-Specific Deubiquitinase.	CYLD USP20	1.10e-03	32	53	2	33669244
Pubmed	Ubiquitin-specific peptidase 2a (USP2a) deubiquitinates and stabilizes β-catenin.	CYLD USP20	1.17e-03	33	53	2	30323974
Pubmed	The ciliogenic transcription factor Rfx3 is required for the formation of the thalamocortical tract by regulating the patterning of prethalamus and ventral telencephalon.	INPP5E SLIT1	1.24e-03	34	53	2	25631876
Pubmed	Patterns of Wnt/Fzd/LRP gene expression during embryonic hematopoiesis.	FZD6 EPOR	1.47e-03	37	53	2	18800919
Pubmed	Discovery and Characterization of ZUFSP/ZUP1, a Distinct Deubiquitinase Class Important for Genome Stability.	CYLD USP9X USP20	1.48e-03	147	53	3	29576527
Interaction	FHL5 interactions	ZNF792 FARS2 ZNF587 SLIT1 ZNF417	6.47e-06	102	52	5	int:FHL5
Cytoband	Xq22.3	NRK PWWP3B	6.75e-04	33	53	2	Xq22.3
GeneFamily	Ubiquitin specific peptidases	CYLD USP9X USP9Y USP20	3.16e-06	56	33	4	366
GeneFamily	Exosome complex	EXOSC8 EXOSC7	2.11e-04	12	33	2	817
Disease	response to perphenazine	PXDN RNF144A	8.56e-04	26	49	2	GO_0097334
Disease	visuospatial function measurement	FARS2 WRAP73	8.56e-04	26	49	2	EFO_0803533
Disease	severe acute respiratory syndrome, COVID-19	EYS PXDN FARS2 USP9X HELQ	8.60e-04	447	49	5	EFO_0000694, MONDO_0100096
Disease	retinal vasculature measurement	FZD6 EYS PXDN DNAH9 WDR72	1.64e-03	517	49	5	EFO_0010554
Disease	Primary Ciliary Dyskinesia	INPP5E DNAH9	2.78e-03	47	49	2	C4551720
Disease	Hallux valgus	EYS SLIT1	4.50e-03	60	49	2	HP_0001822

Protein segments in the cluster

Peptide	Gene	Start	Entry
LVALIIWCYLREESE	CCSMST1	86	Q4G0I0
QVWCGVYLALDVLFC	ADRA2C	121	P18825
LQLWEAYCQVRYLCS	BICDL1	366	Q6ZP65
RYVWQDDFVEDLLCC	FAM200A	161	Q8TCP9
QWLEENYIVCEGVCL	RFX6	126	Q8HWS3
LVWVLYCDLICLDYD	EXOSC8	131	Q96B26
ICGQYFITVWLECVR	LRRC69	291	Q6ZNQ3
DIVWCYFRLEQLECL	NUB1	286	Q9Y5A7
VICLANDQYWRCILD	ANKAR	726	Q7Z5J8
LQIWTVVDFCCEYLE	KLHL36	126	Q8N4N3
TENICLDFYRDCWFL	EYS	46	Q5T1H1
WYIFRVLLQVFLECC	NNAT	16	Q16517
VLLQVFLECCIYWVG	NNAT	21	Q16517
FIRRDLIWFCSEVEC	INPP5E	376	Q9NRR6
ALEQLYPWECFVFCL	PEDS1	161	A5PLL7
ERQLWVAFQCCRDYE	LAX1	281	Q8IWV1
IQLLCVCRLDWANGY	PTPRZ1	11	P23471
HCWVLYVDVLLLECG	EXOSC7	131	Q15024
FERCVISCALYEEFW	PRPF39	376	Q86UA1
PQWICCDIRYLDVSI	METTL3	371	Q86U44
CWYCLESLDDDFLLI	RNF144A	211	P50876
RWPEELECDRLQYCD	FZD6	116	O60353
DNTWEYIFAIDLLCC	ICE1	2111	Q9Y2F5
LVCEETANYLVIWCI	CDC37	181	Q16543
CAWEIVRVEIRRCLY	IFNK	181	Q9P0W0
ILIVWLADQYDAICC	TMEM259	381	Q4ZIN3
LCFTERLEDLVCFWE	EPOR	51	P19235
YRRSLCVLQAWVEDC	KNDC1	1316	Q76NI1
CSWVINIVRFYEVFC	DNAH9	3266	Q9NYC9
FCEELEEFWVYRALL	HELQ	981	Q8TDG4
WEERIFYLLLQECSV	CYLD	16	Q9NQC7
EDWIAYICREILQGL	NRK	151	Q7Z2Y5
WKCLAENAVYLCDRE	USP9X	681	Q93008
CVFWDLYCAAPERRE	SSBP2	66	P81877
FQENWFLLFCRICIY	TRHR	296	P34981
IDWCISLICDYRVRI	PWWP3B	466	Q5H9M0
YTALIEERINLWCDI	SHCBP1L	276	Q9BZQ2
CVLAVWDTCLEYKIL	WRAP73	191	Q9P2S5
FRIEENNEIILCRWY	PGBD1	676	Q96JS3
LEEWILEQLTRLYDC	PPP1R14B	71	Q96C90
DWLERLCQADLIYIS	CMAHP	76	Q9Y471
YNWYLLICRACFDEL	CNGA3	181	Q16281
RYELRDCCWVLCALL	XKR7	51	Q5GH72
QEEWCLLSEAQRCLY	ZNF587	26	Q96SQ5
CDCEILWLADLLKTY	PXDN	196	Q92626
QEEWCLLSEAQRCLY	ZNF417	26	Q8TAU3
WLLCCGEYQDVLIID	WDR72	126	Q3MJ13
EWCACDEELLLVAYK	UBR1	551	Q8IWV7
SCCVYFCLWIPEDQL	TMEM86B	31	Q8N661
LCWVAFCLLVEELIE	TRBV11-3	6	A0A5A6
IWKCLAENAVYLCDR	USP9Y	681	O00507
LWCYACEKEVFLEQR	USP20	81	Q9Y2K6
EEWVLLDEAQRLLYC	ZNF792	26	Q3KQV3
FICDCNLKWLADFLR	SLIT1	441	O75093
LFWCEDERFLKQFCV	FARS2	331	O95363