Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	beta-catenin binding	AMER2 CDH20 NUMB TBL1XR1 NOS2 AXIN1	1.41e-05	120	87	6	GO:0008013
GeneOntologyMolecularFunction	extracellular matrix structural constituent	FBLN1 RELN CILP MUC2 AGRN MUC6	1.73e-04	188	87	6	GO:0005201
GeneOntologyMolecularFunction	calcium- and calmodulin-responsive adenylate cyclase activity	ADCY5 ADCY6	1.86e-04	5	87	2	GO:0008294
GeneOntologyMolecularFunction	ribose phosphate diphosphokinase activity	PRPS2 PRPS1	1.86e-04	5	87	2	GO:0004749
GeneOntologyMolecularFunction	diphosphotransferase activity	PRPS2 PRPS1	2.78e-04	6	87	2	GO:0016778
GeneOntologyMolecularFunction	transcription corepressor activity	HDAC9 TBL1Y RBBP8 TBL1XR1 TBL1X HR	4.96e-04	229	87	6	GO:0003714
GeneOntologyMolecularFunction	cuprous ion binding	ATP7A MUC2	6.62e-04	9	87	2	GO:1903136
GeneOntologyCellularComponent	histone deacetylase complex	HDAC9 TBL1Y TBL1XR1 TBL1X HR	2.97e-05	85	88	5	GO:0000118
GeneOntologyCellularComponent	ribose phosphate diphosphokinase complex	PRPS2 PRPS1	1.74e-04	5	88	2	GO:0002189
GeneOntologyCellularComponent	endocytic vesicle membrane	ATP7A AP2A2 CAMK2A TLR2 LRP1 CUBN	2.75e-04	212	88	6	GO:0030666
GeneOntologyCellularComponent	clathrin-coated pit	AP2A2 LRP1 NUMB CUBN	3.63e-04	80	88	4	GO:0005905
GeneOntologyCellularComponent	transcription repressor complex	TBL1Y RBBP8 TBL1XR1 TBL1X	5.00e-04	87	88	4	GO:0017053
GeneOntologyCellularComponent	inner dynein arm	DNHD1 DNAH7	7.71e-04	10	88	2	GO:0036156
MousePheno	premature death	SMG1 RELN ZBTB20 ATP7A RHBDF1 RBBP8 CAMK2A TNN TLR2 MCM4 GRN CUBN NOS2 AGRN IL4R HR	3.98e-05	1051	69	16	MP:0002083
MousePheno	abnormal liver morphology	UBR2 SMG1 ZBTB20 ATP7A NF1 GAL3ST1 ACOT11 TNN TLR2 LRP1 MCM4 GRN GCK TBL1XR1 NOS2 CLUH REXO1L1P FAN1 HR	4.37e-05	1433	69	19	MP:0000598
MousePheno	abnormal hepatobiliary system morphology	UBR2 SMG1 ZBTB20 ATP7A NF1 GAL3ST1 ACOT11 TNN TLR2 LRP1 MCM4 GRN GCK TBL1XR1 NOS2 CLUH REXO1L1P FAN1 HR	6.55e-05	1476	69	19	MP:0002138
MousePheno	prognathia	SMG1 LTBP3	7.18e-05	3	69	2	MP:0010208
Domain	EGF_CA	FBLN1 FAT4 FAT2 SCUBE2 LRP1 LTBP3 CUBN AGRN	9.12e-08	122	86	8	SM00179
Domain	EGF-like_Ca-bd_dom	FBLN1 FAT4 FAT2 SCUBE2 LRP1 LTBP3 CUBN AGRN	1.03e-07	124	86	8	IPR001881
Domain	EGF_3	FBLN1 FAT4 RELN FAT2 SCUBE2 TNN LRP1 LTBP3 CUBN AGRN	1.26e-07	235	86	10	PS50026
Domain	EGF	FBLN1 FAT4 RELN FAT2 SCUBE2 TNN LRP1 LTBP3 CUBN AGRN	1.26e-07	235	86	10	SM00181
Domain	EGF-like_dom	FBLN1 FAT4 RELN FAT2 SCUBE2 TNN LRP1 LTBP3 CUBN AGRN	2.16e-07	249	86	10	IPR000742
Domain	EGF_1	FBLN1 FAT4 RELN FAT2 SCUBE2 TNN LRP1 LTBP3 CUBN AGRN	2.69e-07	255	86	10	PS00022
Domain	EGF-like_CS	FBLN1 FAT4 RELN FAT2 SCUBE2 TNN LRP1 LTBP3 CUBN AGRN	3.33e-07	261	86	10	IPR013032
Domain	EGF_2	FBLN1 FAT4 RELN FAT2 SCUBE2 TNN LRP1 LTBP3 CUBN AGRN	3.83e-07	265	86	10	PS01186
Domain	EGF_CA	FBLN1 FAT4 SCUBE2 LRP1 LTBP3 CUBN	2.80e-06	86	86	6	PF07645
Domain	EGF_Ca-bd_CS	FBLN1 FAT4 SCUBE2 LRP1 LTBP3 CUBN	5.65e-06	97	86	6	IPR018097
Domain	cEGF	FBLN1 SCUBE2 LRP1 LTBP3	5.80e-06	26	86	4	IPR026823
Domain	cEGF	FBLN1 SCUBE2 LRP1 LTBP3	5.80e-06	26	86	4	PF12662
Domain	EGF_CA	FBLN1 FAT4 SCUBE2 LRP1 LTBP3 CUBN	6.35e-06	99	86	6	PS01187
Domain	ASX_HYDROXYL	FBLN1 FAT4 SCUBE2 LRP1 LTBP3 CUBN	6.74e-06	100	86	6	PS00010
Domain	Growth_fac_rcpt_	FBLN1 FAT4 SCUBE2 TNN LRP1 LTBP3 CUBN	7.66e-06	156	86	7	IPR009030
Domain	LisH	TBL1Y TBL1XR1 TBL1X	7.76e-06	9	86	3	PF08513
Domain	EGF-type_Asp/Asn_hydroxyl_site	FBLN1 FAT4 SCUBE2 LRP1 LTBP3 CUBN	9.43e-06	106	86	6	IPR000152
Domain	G-protein_beta_WD-40_rep	TBL1Y GNB5 SPAG16 TBL1XR1 TBL1X	4.52e-05	85	86	5	IPR020472
Domain	PRPP_SYNTHASE	PRPS2 PRPS1	6.27e-05	3	86	2	PS00114
Domain	PRib_PP_synth_CS	PRPS2 PRPS1	6.27e-05	3	86	2	IPR000842
Domain	CT	NDP MUC2 MUC6	1.36e-04	22	86	3	SM00041
Domain	Cys_knot_C	NDP MUC2 MUC6	2.01e-04	25	86	3	IPR006207
Domain	CTCK_2	NDP MUC2 MUC6	2.01e-04	25	86	3	PS01225
Domain	Rib-P_diPkinase	PRPS2 PRPS1	2.08e-04	5	86	2	IPR005946
Domain	Pribosyltran_N	PRPS2 PRPS1	2.08e-04	5	86	2	IPR029099
Domain	Pribosyltran_N	PRPS2 PRPS1	2.08e-04	5	86	2	PF13793
Domain	Pribosyl_synth	PRPS2 PRPS1	2.08e-04	5	86	2	PF14572
Domain	LisH	TBL1Y TBL1XR1 TBL1X	2.84e-04	28	86	3	SM00667
Domain	LisH	TBL1Y TBL1XR1 TBL1X	2.84e-04	28	86	3	IPR006594
Domain	LISH	TBL1Y TBL1XR1 TBL1X	2.84e-04	28	86	3	PS50896
Domain	EGF	FAT2 SCUBE2 LRP1 CUBN AGRN	2.90e-04	126	86	5	PF00008
Domain	Adcy_conserved_dom	ADCY5 ADCY6	3.11e-04	6	86	2	IPR009398
Domain	WxxW_domain	CILP MUC2	3.11e-04	6	86	2	IPR025155
Domain	Mucin2_WxxW	CILP MUC2	3.11e-04	6	86	2	PF13330
Domain	DUF1053	ADCY5 ADCY6	3.11e-04	6	86	2	PF06327
Domain	AC_N	ADCY5 ADCY6	5.76e-04	8	86	2	IPR032628
Domain	Adcy	ADCY5 ADCY6	5.76e-04	8	86	2	IPR030672
Domain	AC_N	ADCY5 ADCY6	5.76e-04	8	86	2	PF16214
Domain	LAM_G_DOMAIN	FAT4 FAT2 AGRN	7.08e-04	38	86	3	PS50025
Domain	WD40_repeat_CS	TBL1Y GNB5 SPAG16 TBL1XR1 TBL1X	9.64e-04	164	86	5	IPR019775
Domain	LamG	FAT4 FAT2 AGRN	1.09e-03	44	86	3	SM00282
Domain	Pribosyltran	PRPS2 PRPS1	1.12e-03	11	86	2	PF00156
Domain	EGF_3	SCUBE2 CUBN	1.34e-03	12	86	2	PF12947
Domain	TIL	MUC2 MUC6	1.34e-03	12	86	2	PF01826
Domain	EGF_dom	SCUBE2 CUBN	1.34e-03	12	86	2	IPR024731
Domain	PRTase-like	PRPS2 PRPS1	1.34e-03	12	86	2	IPR029057
Domain	PRibTrfase_dom	PRPS2 PRPS1	1.34e-03	12	86	2	IPR000836
Domain	-	PRPS2 PRPS1	1.34e-03	12	86	2	3.40.50.2020
Domain	C8	MUC2 MUC6	1.34e-03	12	86	2	PF08742
Domain	Quinoprot_gluc/sorb_DH	LRP1 TBL1X	1.34e-03	12	86	2	IPR011041
Domain	Unchr_dom_Cys-rich	MUC2 MUC6	1.58e-03	13	86	2	IPR014853
Domain	C8	MUC2 MUC6	1.58e-03	13	86	2	SM00832
Domain	Dynein_HC_stalk	DNHD1 DNAH7	1.84e-03	14	86	2	IPR024743
Domain	Dynein_heavy_dom-2	DNHD1 DNAH7	1.84e-03	14	86	2	IPR013602
Domain	DHC_N2	DNHD1 DNAH7	1.84e-03	14	86	2	PF08393
Domain	MT	DNHD1 DNAH7	1.84e-03	14	86	2	PF12777
Domain	TIL_dom	MUC2 MUC6	1.84e-03	14	86	2	IPR002919
Domain	DHC_fam	DNHD1 DNAH7	2.12e-03	15	86	2	IPR026983
Domain	Dynein_heavy_dom	DNHD1 DNAH7	2.12e-03	15	86	2	IPR004273
Domain	Dynein_heavy	DNHD1 DNAH7	2.12e-03	15	86	2	PF03028
Domain	VWD	MUC2 MUC6	2.41e-03	16	86	2	SM00216
Domain	VWF_type-D	MUC2 MUC6	2.41e-03	16	86	2	IPR001846
Domain	VWFD	MUC2 MUC6	2.41e-03	16	86	2	PS51233
Domain	VWD	MUC2 MUC6	2.41e-03	16	86	2	PF00094
Domain	Laminin_G	FAT4 FAT2 AGRN	2.42e-03	58	86	3	IPR001791
Domain	A/G_cyclase_CS	ADCY5 ADCY6	2.72e-03	17	86	2	IPR018297
Domain	CTCK_1	NDP MUC2	3.06e-03	18	86	2	PS01185
Domain	Nucleotide_cyclase	ADCY5 ADCY6	3.06e-03	18	86	2	IPR029787
Domain	-	ADCY5 ADCY6	3.06e-03	18	86	2	3.30.70.1230
Domain	VWC_out	MUC2 MUC6	3.41e-03	19	86	2	SM00215
Domain	GUANYLATE_CYCLASE_1	ADCY5 ADCY6	3.41e-03	19	86	2	PS00452
Domain	Guanylate_cyc	ADCY5 ADCY6	3.41e-03	19	86	2	PF00211
Domain	GUANYLATE_CYCLASE_2	ADCY5 ADCY6	3.41e-03	19	86	2	PS50125
Domain	A/G_cyclase	ADCY5 ADCY6	3.41e-03	19	86	2	IPR001054
Domain	CYCc	ADCY5 ADCY6	3.41e-03	19	86	2	SM00044
Pathway	REACTOME_NR1H2_AND_NR1H3_MEDIATED_SIGNALING	TBL1Y TBL1XR1 TBL1X	3.10e-05	13	69	3	MM15622
Pubmed	Hepatic deficiency in transcriptional cofactor TBL1 promotes liver steatosis and hypertriglyceridemia.	TBL1Y TBL1XR1 TBL1X	1.56e-07	5	88	3	21459324
Pubmed	Exchange Factor TBL1 and Arginine Methyltransferase PRMT6 Cooperate in Protecting G Protein Pathway Suppressor 2 (GPS2) from Proteasomal Degradation.	PRMT6 TBL1Y TBL1X	1.56e-07	5	88	3	26070566
Pubmed	Structure of the MeCP2-TBLR1 complex reveals a molecular basis for Rett syndrome and related disorders.	TBL1Y TBL1XR1 TBL1X	3.11e-07	6	88	3	28348241
Pubmed	Cytokine-induced iNOS and ERK1/2 inhibit adenylyl cyclase type 5/6 activity and stimulate phosphodiesterase 4D5 activity in intestinal longitudinal smooth muscle.	NOS2 ADCY5 ADCY6	3.11e-07	6	88	3	24944202
Pubmed	The nuclear receptor corepressor deacetylase activating domain is essential for repression by thyroid hormone receptor.	TBL1Y TBL1XR1 TBL1X	5.44e-07	7	88	3	15695367
Pubmed	Zbtb7c is a molecular 'off' and 'on' switch of Mmp gene transcription.	TBL1Y TBL1XR1 TBL1X	5.44e-07	7	88	3	27646874
Pubmed	A SUMOylation-dependent pathway mediates transrepression of inflammatory response genes by PPAR-gamma.	TBL1Y TBL1XR1 TBL1X	8.69e-07	8	88	3	16127449
Pubmed	Rett syndrome mutations abolish the interaction of MeCP2 with the NCoR/SMRT co-repressor.	TBL1Y TBL1XR1 TBL1X	8.69e-07	8	88	3	23770565
Pubmed	A corepressor/coactivator exchange complex required for transcriptional activation by nuclear receptors and other regulated transcription factors.	TBL1Y TBL1XR1 TBL1X	1.85e-06	10	88	3	14980219
Pubmed	Comprehensive analysis of the expression patterns of the adenylate cyclase gene family in the developing and adult mouse brain.	RELN ADCY5 ADCY6	1.85e-06	10	88	3	16615126
Pubmed	Paralog knockout profiling identifies DUSP4 and DUSP6 as a digenic dependence in MAPK pathway-driven cancers.	PRMT6 PRPS2 METAP1 TRAF3 ZBTB20 AP2A2 LRP1 GCK TBL1XR1 TBL1X PRPS1	2.39e-06	730	88	11	34857952
Pubmed	Comparative oncogenomics implicates the neurofibromin 1 gene (NF1) as a breast cancer driver.	NF1 MCM4	6.33e-06	2	88	2	22851646
Pubmed	Worm expulsion of Gymnophalloides seoi from C57BL/6 mice: role of metacercarial exosomes in upregulating TLR2 and MUC2 expression in intestinal tissues.	TLR2 MUC2	6.33e-06	2	88	2	30019213
Pubmed	Knockout of adenylyl cyclase isoform 5 or 6 differentially modifies the β1-adrenoceptor-mediated inotropic response.	ADCY5 ADCY6	6.33e-06	2	88	2	31009605
Pubmed	TBL1X: At the crossroads of transcriptional and posttranscriptional regulation.	TBL1XR1 TBL1X	6.33e-06	2	88	2	36206873
Pubmed	The central exons of the human MUC2 and MUC6 mucins are highly repetitive and variable in sequence between individuals.	MUC2 MUC6	6.33e-06	2	88	2	30504806
Pubmed	The complete genomic organization of the human MUC6 and MUC2 mucin genes.	MUC2 MUC6	6.33e-06	2	88	2	15081123
Pubmed	The calcium paradoxon of renin release: calcium suppresses renin exocytosis by inhibition of calcium-dependent adenylate cyclases AC5 and AC6.	ADCY5 ADCY6	6.33e-06	2	88	2	17068292
Pubmed	High-fat Diet Alters the Glycosylation Patterns of Duodenal Mucins in a Murine Model.	MUC2 MUC6	6.33e-06	2	88	2	32141795
Pubmed	MUC2 and MUC6 apomucins expression in human gastric neoplasm: an immunohistochemical analysis.	MUC2 MUC6	6.33e-06	2	88	2	20878553
Pubmed	X-linked late-onset sensorineural deafness caused by a deletion involving OA1 and a novel gene containing WD-40 repeats.	TBL1Y TBL1X	6.33e-06	2	88	2	10330347
Pubmed	Adenylyl cyclase 5-generated cAMP controls cerebral vascular reactivity during diabetic hyperglycemia.	ADCY5 ADCY6	6.33e-06	2	88	2	31162142
Pubmed	Differential regulation of vascular tone and remodeling via stimulation of type 2 and type 6 adenylyl cyclases in the ductus arteriosus.	ADCY5 ADCY6	6.33e-06	2	88	2	20431059
Pubmed	Innate Anti-microbial and Anti-chemotaxis Properties of Progranulin in an Acute Otitis Media Mouse Model.	TLR2 GRN	6.33e-06	2	88	2	30619312
Pubmed	[Significance of lipopolysaccharides, toll-like receptor and inducible nitric oxide synthase in hepatopulmonary syndrome].	TLR2 NOS2	6.33e-06	2	88	2	19953876
Pubmed	[Increased activity of PRPP synthetase].	PRPS2 PRPS1	6.33e-06	2	88	2	18409517
Pubmed	Adenylyl cyclase subtype-specific compartmentalization: differential regulation of L-type Ca2+ current in ventricular myocytes.	ADCY5 ADCY6	6.33e-06	2	88	2	23609114
Pubmed	Adenylyl cyclase type 5 protein expression during cardiac development and stress.	ADCY5 ADCY6	6.33e-06	2	88	2	19734365
Pubmed	TLR2 signal influences the iNOS/NO responses and worm development in C57BL/6J mice infected with Clonorchis sinensis.	TLR2 NOS2	6.33e-06	2	88	2	28784165
Pubmed	Global gene expression patterns and induction of innate immune response in human laryngeal epithelial cells in response to Acinetobacter baumannii outer membrane protein A.	TLR2 NOS2	6.33e-06	2	88	2	18625015
Pubmed	PRPS1-mediated purine biosynthesis is critical for pluripotent stem cell survival and stemness.	PRPS2 PRPS1	6.33e-06	2	88	2	33493137
Pubmed	Asymmetric segregation and self-renewal of hematopoietic stem and progenitor cells with endocytic Ap2a2.	AP2A2 NUMB	6.33e-06	2	88	2	22174158
Pubmed	SUMOylation of TBL1 and TBLR1 promotes androgen-independent prostate cancer cell growth.	TBL1XR1 TBL1X	6.33e-06	2	88	2	27129164
Pubmed	Tissue-differential expression of two distinct genes for phosphoribosyl pyrophosphate synthetase and existence of the testis-specific transcript.	PRPS2 PRPS1	6.33e-06	2	88	2	2537655
Pubmed	Streptococcus pyogenes arginine and citrulline catabolism promotes infection and modulates innate immunity.	NOS2 HR	6.33e-06	2	88	2	24144727
Pubmed	Withania somnifera reverses Alzheimer's disease pathology by enhancing low-density lipoprotein receptor-related protein in liver.	ZBTB20 LRP1	6.33e-06	2	88	2	22308347
Pubmed	Virus-Mediated Genome Editing via Homology-Directed Repair in Mitotic and Postmitotic Cells in Mammalian Brain.	ZBTB20 CAMK2A	6.33e-06	2	88	2	29056297
Pubmed	Transducin β-like 1, X-linked and nuclear receptor co-repressor cooperatively augment the ligand-independent stimulation of TRH and TSHβ gene promoters by thyroid hormone receptors.	TBL1Y TBL1X	6.33e-06	2	88	2	29794369
Pubmed	Stimulation of renin secretion by catecholamines is dependent on adenylyl cyclases 5 and 6.	ADCY5 ADCY6	6.33e-06	2	88	2	21282557
Pubmed	Alzheimer Disease Pathology-Associated Polymorphism in a Complex Variable Number of Tandem Repeat Region Within the MUC6 Gene, Near the AP2A2 Gene.	AP2A2 MUC6	6.33e-06	2	88	2	31748784
Pubmed	Cloning and sequence of partial cDNAs encoding the human type V and VI adenylyl cyclases and subsequent RNA-quantification in various tissues.	ADCY5 ADCY6	6.33e-06	2	88	2	10481931
Pubmed	Protein interactome reveals converging molecular pathways among autism disorders.	FBLN1 TRAF3 NF1 CAMK2A GRN LTBP3 AGRN TRIM3 AXIN1	1.26e-05	560	88	9	21653829
Pubmed	Comparison of an expanded ataxia interactome with patient medical records reveals a relationship between macular degeneration and ataxia.	FBLN1 LRP1 GRN LTBP3 AGRN	1.29e-05	118	88	5	21078624
Pubmed	Secretory carcinoma of breast: pattern of MUC 2/MUC 4/MUC 6 expression.	MUC2 MUC6	1.90e-05	3	88	2	23305535
Pubmed	Tbl1 promotes Wnt-β-catenin signaling-induced degradation of the Tcf7l1 protein in mouse embryonic stem cells.	TBL1Y TBL1X	1.90e-05	3	88	2	38639717
Pubmed	Promoter regions of the human X-linked housekeeping genes PRPS1 and PRPS2 encoding phosphoribosylpyrophosphate synthetase subunit I and II isoforms.	PRPS2 PRPS1	1.90e-05	3	88	2	1314091
Pubmed	Transducin β-like protein 1 recruits nuclear factor κB to the target gene promoter for transcriptional activation.	TBL1Y TBL1X	1.90e-05	3	88	2	21189284
Pubmed	Partial reconstitution of mammalian phosphoribosylpyrophosphate synthetase in Escherichia coli cells. Coexpression of catalytic subunits with the 39-kDa associated protein leads to formation of soluble multimeric complexes of various compositions.	PRPS2 PRPS1	1.90e-05	3	88	2	9366267
Pubmed	Dynamic regulation of cAMP synthesis through anchored PKA-adenylyl cyclase V/VI complexes.	ADCY5 ADCY6	1.90e-05	3	88	2	16973443
Pubmed	Adenylyl cyclase 5 links changes in calcium homeostasis to cAMP-dependent cyst growth in polycystic liver disease.	ADCY5 ADCY6	1.90e-05	3	88	2	27826057
Pubmed	Cadherin-catenin adhesion system and mucin expression: a comparison between young and older patients with gastric carcinoma.	MUC2 MUC6	1.90e-05	3	88	2	18825309
Pubmed	Francisella tularensis live vaccine strain induces macrophage alternative activation as a survival mechanism.	TLR2 IL4R	1.90e-05	3	88	2	18768873
Pubmed	Adenomatous and foveolar gastric dysplasia: distinct patterns of mucin expression and background intestinal metaplasia.	MUC2 MUC6	1.90e-05	3	88	2	18300795
Pubmed	The dorsal striatum expressing adenylyl cyclase-5 controls behavioral sensitivity of the righting reflex to high-dose ethanol.	CAMK2A ADCY5	1.90e-05	3	88	2	23063718
Pubmed	Reelin depletion in the entorhinal cortex of human amyloid precursor protein transgenic mice and humans with Alzheimer's disease.	RELN ZBTB20	1.90e-05	3	88	2	17360894
Pubmed	Molecular mechanism of c-Myc and PRPS1/2 against thiopurine resistance in Burkitt's lymphoma.	PRPS2 PRPS1	1.90e-05	3	88	2	32391636
Pubmed	Latent transforming growth factor beta-binding protein-3 and fibulin-1C interact with the extracellular domain of the heparin-binding EGF-like growth factor precursor.	FBLN1 LTBP3	1.90e-05	3	88	2	11846885
Pubmed	Gq-mediated Ca2+ signals inhibit adenylyl cyclases 5/6 in vascular smooth muscle cells.	ADCY5 ADCY6	1.90e-05	3	88	2	19889965
Pubmed	Proinflammatory MG-63 cells response infection with Enterococcus faecalis cps2 evaluated by the expression of TLR-2, IL-1β, and iNOS mRNA.	TLR2 NOS2	1.90e-05	3	88	2	28800779
Pubmed	Cloning of cDNAs for human phosphoribosylpyrophosphate synthetases 1 and 2 and X chromosome localization of PRPS1 and PRPS2 genes.	PRPS2 PRPS1	1.90e-05	3	88	2	1962753
Pubmed	Expression of TLR 2, TLR 4 and iNOS in cervical monocytes of Chlamydia trachomatis-infected women and their role in host immune response.	TLR2 NOS2	1.90e-05	3	88	2	21883620
Pubmed	Nitric oxide is involved in Mycobacterium bovis bacillus Calmette-Guérin-activated Jagged1 and Notch1 signaling.	TLR2 NOS2	1.90e-05	3	88	2	20147635
Pubmed	Expression of phosphoribosyl pyrophosphate synthetase genes in U87 glioma cells with ERN1 knockdown: effect of hypoxia and endoplasmic reticulum stress.	PRPS2 PRPS1	1.90e-05	3	88	2	25816608
Pubmed	Constitutive inhibitory G protein activity upon adenylyl cyclase-dependent cardiac contractility is limited to adenylyl cyclase type 6.	ADCY5 ADCY6	1.90e-05	3	88	2	31173603
Pubmed	Reelin signaling pathway genotypes and Alzheimer disease in a Spanish population.	RELN CAMK2A	1.90e-05	3	88	2	24384746
Pubmed	Gastric and intestinal phenotypic cell marker expressions in gastric differentiated-type carcinomas: association with E-cadherin expression and chromosomal changes.	MUC2 MUC6	1.90e-05	3	88	2	16447040
Pubmed	Chromosomal mapping of human adenylyl cyclase genes type III, type V and type VI.	ADCY5 ADCY6	1.90e-05	3	88	2	8034296
Pubmed	Genetic variation in MUC1, MUC2 and MUC6 genes and evolution of gastric cancer precursor lesions in a long-term follow-up in a high-risk area in Spain.	MUC2 MUC6	1.90e-05	3	88	2	22402132
Pubmed	Mutant Tbl1x male mice have a short life span and do not breed: unexpected findings.	TBL1Y TBL1X	1.90e-05	3	88	2	38381448
Pubmed	Toll-like receptor (TLR) 2 induced through TLR4 signaling initiated by Helicobacter pylori cooperatively amplifies iNOS induction in gastric epithelial cells.	TLR2 NOS2	1.90e-05	3	88	2	17855767
Pubmed	Regulation of type V adenylate cyclase by Ric8a, a guanine nucleotide exchange factor.	ADCY5 ADCY6	1.90e-05	3	88	2	17593019
Pubmed	Arginylation regulates purine nucleotide biosynthesis by enhancing the activity of phosphoribosyl pyrophosphate synthase.	PRPS2 PRPS1	1.90e-05	3	88	2	26175007
Pubmed	Mapping the interactome of HPV E6 and E7 oncoproteins with the ubiquitin-proteasome system.	ASB13 TRAF3 ZBTB20 TRIM3 KLHL26	2.75e-05	138	88	5	28786561
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	TRAF3 NF1 TCF20 AP2A2 TBL1Y CAMK2A LRP1 TBL1XR1 AGRN TRIM3 TBL1X	3.18e-05	963	88	11	28671696
Pubmed	Comparative analysis of 1196 orthologous mouse and human full-length mRNA and protein sequences.	ATP7A NF1 NDP	3.46e-05	25	88	3	8889551
Pubmed	MyD88-dependent but Toll-like receptor 2-independent innate immunity to Listeria: no role for either in macrophage listericidal activity.	TLR2 NOS2	3.79e-05	4	88	2	12244184
Pubmed	Innate immunity of the ocular surface and ocular surface inflammatory disorders.	TLR2 IL4R	3.79e-05	4	88	2	18813073
Pubmed	Expression of MUC2, MUC5AC, MUC5B, and MUC6 mucins in colorectal cancers and their association with the CpG island methylator phenotype.	MUC2 MUC6	3.79e-05	4	88	2	23807779
Pubmed	Differential dopamine receptor subtype regulation of adenylyl cyclases in lipid rafts in human embryonic kidney and renal proximal tubule cells.	ADCY5 ADCY6	3.79e-05	4	88	2	25049074
Pubmed	Gr-1+CD115+ immature myeloid suppressor cells mediate the development of tumor-induced T regulatory cells and T-cell anergy in tumor-bearing host.	NOS2 IL4R	3.79e-05	4	88	2	16424049
Pubmed	Thymic alterations induced by partial hepatectomy: Upregulation of glycoprotein 96, CD91 and TLR2 and generation of regulatory T cells.	TLR2 LRP1	3.79e-05	4	88	2	25693689
Pubmed	Associations between the expression of mucins (MUC1, MUC2, MUC5AC and MUC6) and clinicopathologic parameters of human breast carcinomas.	MUC2 MUC6	3.79e-05	4	88	2	33154304
Pubmed	Gastric mucin expression in first-degree relatives of gastric cancer patients.	MUC2 MUC6	3.79e-05	4	88	2	24901817
Pubmed	TBL1-TBLR1 and beta-catenin recruit each other to Wnt target-gene promoter for transcription activation and oncogenesis.	TBL1XR1 TBL1X	3.79e-05	4	88	2	18193033
Pubmed	The role of HGF-MET pathway and CCDC66 cirRNA expression in EGFR resistance and epithelial-to-mesenchymal transition of lung adenocarcinoma cells.	CCDC66 RBBP8	3.79e-05	4	88	2	29855336
Pubmed	Leishmania mexicana promastigotes inhibit macrophage IL-12 production via TLR-4 dependent COX-2, iNOS and arginase-1 expression.	TLR2 NOS2	3.79e-05	4	88	2	21664694
Pubmed	Evaluation of MUC1, MUC2, MUC5AC, and MUC6 Expression Differences in Lung Adenocarcinoma Subtypes by Using a Final Immunoreactivity Score (FIRS).	MUC2 MUC6	3.79e-05	4	88	2	36367122
Pubmed	Epigenetic regulation (DNA methylation, histone modifications) of the 11p15 mucin genes (MUC2, MUC5AC, MUC5B, MUC6) in epithelial cancer cells.	MUC2 MUC6	3.79e-05	4	88	2	17471237
Pubmed	The mouse secreted gel-forming mucin gene cluster.	MUC2 MUC6	3.79e-05	4	88	2	14984930
Pubmed	TBL1 and TBLR1 phosphorylation on regulated gene promoters overcomes dual CtBP and NCoR/SMRT transcriptional repression checkpoints.	TBL1XR1 TBL1X	3.79e-05	4	88	2	18374649
Pubmed	Reelin controls position of autonomic neurons in the spinal cord.	RELN NOS2	3.79e-05	4	88	2	10880573
Pubmed	Effects of the Helicobacter pylori Virulence Factor CagA and Ammonium Ion on Mucins in AGS Cells.	MUC2 MUC6	3.79e-05	4	88	2	29869461
Pubmed	Mucins in neoplastic spectrum of colorectal polyps: can they provide predictions?	MUC2 MUC6	3.79e-05	4	88	2	20929551
Pubmed	Polymorphisms in MUC1, MUC2, MUC5B and MUC6 genes are not associated with the risk of chronic atrophic gastritis.	MUC2 MUC6	3.79e-05	4	88	2	21596555
Pubmed	MUC1, MUC2, MUC5AC, and MUC6 in colorectal cancer: expression profiles and clinical significance.	MUC2 MUC6	3.79e-05	4	88	2	27298226
Pubmed	Mucin expression profile in Barrett's, dysplasia, adenocarcinoma sequence in the esophagus.	MUC2 MUC6	3.79e-05	4	88	2	17401217
Pubmed	Characterization of mouse muc6 and evidence of conservation of the gel-forming mucin gene cluster between human and mouse.	MUC2 MUC6	3.79e-05	4	88	2	12676567
Pubmed	Transcriptional co-factor Transducin beta-like (TBL) 1 acts as a checkpoint in pancreatic cancer malignancy.	TBL1Y TBL1X	3.79e-05	4	88	2	26070712
Pubmed	Expression profile of mucins (MUC1, MUC2, MUC5AC, and MUC6) in ovarian mucinous tumours: changes in expression from benign to malignant tumours.	MUC2 MUC6	3.79e-05	4	88	2	25298197
Pubmed	Chronic filarial infection provides protection against bacterial sepsis by functionally reprogramming macrophages.	TLR2 IL4R	3.79e-05	4	88	2	25611587
Cytoband	Ensembl 112 genes in cytogenetic band chr11p15	DNHD1 OR52K1 SCUBE2 AP2A2 OR52E6 OR52K2 OR52P1 MUC2 MUC6 TRIM3	1.38e-07	564	88	10	chr11p15
Cytoband	11p15.4	DNHD1 OR52K1 OR52E6 OR52K2 OR52P1	4.36e-05	200	88	5	11p15.4
Cytoband	11p15.5	AP2A2 MUC2 MUC6 TRIM3	8.19e-05	118	88	4	11p15.5
Cytoband	4q23	METAP1 ADH1C	6.75e-04	20	88	2	4q23
Cytoband	Ensembl 112 genes in cytogenetic band chr4q23	METAP1 ADH1C	2.32e-03	37	88	2	chr4q23
GeneFamily	Olfactory receptors, family 52	OR52K1 OR52E6 OR52K2 OR52P1	2.37e-05	49	62	4	165
GeneFamily	Adenylate cyclases\|Deafness associated genes	ADCY5 ADCY6	5.12e-04	10	62	2	53
GeneFamily	Cadherin related	FAT4 FAT2	1.52e-03	17	62	2	24
GeneFamily	WD repeat domain containing	TBL1Y GNB5 SPAG16 TBL1XR1 TBL1X	2.03e-03	262	62	5	362
GeneFamily	CD molecules\|Mucins	MUC2 MUC6	2.33e-03	21	62	2	648
ToppCell	cellseq2-Epithelial-Epithelial_Airway-Basal/Suprabasal-Suprabasal\|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	FAT2 VILL ABCA13 IL20RB NOS2 ADH1C	1.56e-06	180	88	6	535a890bde0d978b461c2d4c571529b585c76b21
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ZBTB20 ABCA13 RBBP8 SPAG16 DNAH7 ADCY5	2.00e-06	188	88	6	af740fa78542438fdff627ea1f74f4eee43316be
ToppCell	primary_visual_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Igfbp6_Pltp\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	HDAC9 FAT4 RELN ZBTB20 CDH20	8.35e-06	139	88	5	9e9f29f92dbe65b26cc78b3a1c00778c6a701f5b
ToppCell	primary_visual_cortex-Neuronal-GABAergic_neuron-Lamp5-Lamp5_Ntn1_Npy2r\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	HDAC9 FAT4 RELN CDH20 NDP	1.29e-05	152	88	5	8ff5a178a8f3550d89a003c0858820aab3773386
ToppCell	Globus_pallidus-Endothelial-ENDOTHELIAL_STALK-Flt1_1-Endothelial_Stalk.Flt1.Mgp_(Gkn3)-\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	ABCA13 IL20RB CUBN MUC6	2.13e-05	82	88	4	ea3bdd7b871269eacb81167c6cf59a0e21bf6d83
ToppCell	Globus_pallidus-Endothelial-ENDOTHELIAL_STALK-Flt1_1-Endothelial_Stalk.Flt1.Mgp_(Gkn3)--\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	ABCA13 IL20RB CUBN MUC6	2.13e-05	82	88	4	72d5a55ca7c03e9c54f865524e206b288f242017
ToppCell	Globus_pallidus-Endothelial-ENDOTHELIAL_STALK-Flt1_1-Endothelial_Stalk.Flt1.Mgp_(Gkn3)\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	ABCA13 IL20RB CUBN MUC6	2.13e-05	82	88	4	e500582511814a067852dc3bd78d19937c28ba60
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-Adaptive_/_Maladaptive_/_Repairing_Fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	FBLN1 CILP LRP1 ATP10B HR	2.47e-05	174	88	5	9c916af5eebd932f67dc9117e1d26ff194a2ff2c
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	FBLN1 CILP LRP1 ATP10B HR	2.47e-05	174	88	5	bc71521f44a5fe013af42b06b5d1bd2446ecf3b5
ToppCell	PBMC-Control-cDC_12\|Control / Compartment, Disease Groups and Clusters	PRMT6 METAP1 RBBP8 MCM4 PRPS1	3.06e-05	182	88	5	4774066d0f9986abc3d13a2a3bc99ce4f1327ae0
ToppCell	TCGA-Thryoid-Primary_Tumor-Thyroid_Papillary_Carcinoma-Classical-4\|TCGA-Thryoid / Sample_Type by Project: Shred V9	RHBDF1 RBBP8 ST6GALNAC5 MCM4 AXIN1	3.22e-05	184	88	5	d9659d1e4465fec68f48a22edef443f354f6c7cf
ToppCell	droplet-Kidney-KIDNEY-1m-Epithelial-kidney_loop_of_Henle_ascending_limb_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	IVNS1ABP PRPS2 ABCA13 LTBP3 ADCY6	3.31e-05	185	88	5	af86e75096c1812ae27a78405355957ee8043d84
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ZBTB20 ABCA13 SPAG16 DNAH7 ADCY5	3.40e-05	186	88	5	f0c8de4f6ae9047b9108a47a2af8c5f42bc103b0
ToppCell	droplet-Kidney-KIDNEY-30m-Epithelial-Epcam_____kidney_distal_convoluted_tubule_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PRPS2 GAL3ST1 ABCA13 DIPK1B ADCY6	3.57e-05	188	88	5	ab6fa1beff91584d9303c2a33735de89aae8d5cd
ToppCell	droplet-Kidney-nan-3m-Epithelial-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	IVNS1ABP PRPS2 GAL3ST1 ABCA13 ADCY6	3.85e-05	191	88	5	297bc79adc5fef211497819b4861b52cd26ac754
ToppCell	droplet-Kidney-nan-3m-Epithelial-Epcam____thick_ascending_tube_S_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	IVNS1ABP PRPS2 GAL3ST1 ABCA13 ADCY6	3.85e-05	191	88	5	e1ec165ba6578cefd88895e7e183190e79f733a4
ToppCell	cellseq-Epithelial-Epithelial_Glandular-Goblet\|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	VILL ABCA13 ATP10B NOS2 ADH1C	4.05e-05	193	88	5	71bf8fb5314b79cb30f4eb9c8459b21f10cd6d35
ToppCell	cellseq-Epithelial-Epithelial_Glandular-Goblet-Goblet\|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	VILL ABCA13 ATP10B NOS2 ADH1C	4.05e-05	193	88	5	b05e110b13d35d34294357c8e1c4fd23bf4b6c92
ToppCell	Frontal_cortex-Neuronal-Excitatory-eN1(Slc17a7)-eN1_2-Parm1-Excitatory_Neuron.Slc17a7.Parm1.Cadm2_(Deep_layer_pyramidal_cells--layer_5)\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	ABCA13 TNN MUC2	4.14e-05	34	88	3	c217c09c1d7e84f14b9e0d1e7c6e8e916b3c7d10
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	IVNS1ABP ACOT11 RBBP8 SPAG16 DNAH7	4.15e-05	194	88	5	93c68c31e39fa44c1d05d7d4997f4f086da4e738
ToppCell	Nasal_Brush\|World / Tissue, Lineage and Cell class of Lung Cells from 10X	ABCA13 IL20RB ATP10B NOS2 ADH1C	4.25e-05	195	88	5	7509b980b6b293df02bec619ef5b83a6c7b49c03
ToppCell	(5)_Fibroblasts-(5)_Fibroblast-E\|(5)_Fibroblasts / Lung cell shreds - cell class (v4) and cell subclass (v4)	FBLN1 CILP LRP1 GRN ADH1C	4.46e-05	197	88	5	9b1c1d72c5a8c90d71ae31e4c198d2276872eaa0
ToppCell	droplet-Limb_Muscle-MUSCLE-1m-Mesenchymal-chondrocyte-like\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FBLN1 SCUBE2 CILP LRP1 LTBP3	4.57e-05	198	88	5	524305c5d7b1d53e86ec0af775efefa3e0955e47
ToppCell	Tracheal-NucSeq-Epithelial-Epi_airway_basal\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	FAT2 ABCA13 RBBP8 NOS2 IL4R	4.57e-05	198	88	5	5374b0e98d669f36a0571d3c006c7bd5e3c8e87f
ToppCell	5'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.2.1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ABCA13 ZNF664 SPAG16 DNAH7 ADH1C	4.57e-05	198	88	5	d0ecace1fad24ce50b0935036fabb07e6c9e372d
ToppCell	droplet-Limb_Muscle-nan-3m-Mesenchymal-chondrocyte-like\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FBLN1 SCUBE2 CILP LRP1 LTBP3	4.68e-05	199	88	5	edd5300da1a3b758210ff8f949e9d1988b8bc7e2
ToppCell	Parenchymal-10x5prime-Epithelial-Epi_airway_secretory-Secretory_Goblet\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	ABCA13 IL20RB ATP10B NOS2 ADH1C	4.68e-05	199	88	5	3c3133d0aa65338a576634def13e7f0f5c573a10
ToppCell	10x3'2.3-week_17-19-Mesenchymal_fibro-stroma-arteriolar_fibroblast\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	FBLN1 FAT4 CILP LRP1 ADH1C	4.68e-05	199	88	5	95d95e9b7bd3933188998ae94986213eb0f1e5ea
ToppCell	Tracheal-10x5prime-Epithelial-Epi_airway_secretory-Secretory_Goblet\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	VILL ABCA13 ATP10B NOS2 ADH1C	4.68e-05	199	88	5	e03bdc7cb825e287f41b834ec6061d23c1c03b04
Drug	aluminum	RELN TCF20 TBL1Y GNB5 SPAG16 NOS2 ADCY5 ADCY6 TBL1X	3.25e-08	184	86	9	CID000104727
Drug	Streptomycin sulfate [3810-74-0]; Up 200; 2.8uM; MCF7; HT_HG-U133A	TRAF3 NF1 SCUBE2 MBNL2 TUBGCP2 ADCY6 TRIM3	1.02e-05	198	86	7	7194_UP
Drug	LY294002; Up 200; 10uM; PC3; HG-U133A	ASB13 ZBTB20 RHBDF1 CILP MBNL2 ATP10B AGRN	1.02e-05	198	86	7	461_UP
Drug	chlorpromazine hydrochloride; Up 200; 1uM; HL60; HT_HG-U133A	CILP NDP GCK AGRN MUC6 TRIM3 HR	1.05e-05	199	86	7	2677_UP
Drug	guanosine 5'-diphosphate disodium salt	PRPS2 NF1 AP2A2 TBL1Y GNB5 GCK SPAG16 ADCY5 ADCY6 TBL1X PRPS1	3.22e-05	648	86	11	CID000000730
Drug	GTP - Na	PRPS2 HDAC9 NF1 AP2A2 TBL1Y GNB5 SPAG16 NOS2 ADCY5 ADCY6 TBL1X NUP205 PRPS1	4.12e-05	923	86	13	CID000000762
Drug	magnesium fluoride	NF1 TBL1Y GNB5 TBL1X	4.82e-05	53	86	4	CID000024546
Drug	17-AAG; Up 200; 1uM; HL60; HT_HG-U133A	ZBTB20 NF1 MBNL2 TBL1Y ATP10B MUC6	6.85e-05	183	86	6	6166_UP
Drug	AC1LAGWX	ACOT11 LRP1 NDP ADCY5	6.89e-05	58	86	4	CID000513616
Drug	Dihydroergotoxine mesylate [8067-24-1]; Down 200; 6.4uM; MCF7; HT_HG-U133A	FBLN1 TRAF3 NF1 MBNL2 TLR2 TRIM3	8.93e-05	192	86	6	4152_DN
Drug	Fenoprofen calcium salt dihydrate [53746-45-5]; Down 200; 7.2uM; MCF7; HT_HG-U133A	NF1 TBL1Y MCM4 TUBGCP2 ADCY6 TRIM3	8.93e-05	192	86	6	3612_DN
Drug	estradiol; Up 200; 0.01uM; MCF7; HT_HG-U133A	RELN NF1 TUBGCP2 ADCY6 TRIM3 VEGFB	8.93e-05	192	86	6	5955_UP
Drug	Bacampicillin hydrochloride [37661-08-8]; Down 200; 8uM; MCF7; HT_HG-U133A	PAOX FBLN1 TBL1Y GRB7 MUC6 HR	9.46e-05	194	86	6	4417_DN
Drug	5194442; Down 200; 20uM; PC3; HT_HG-U133A	FBLN1 ZBTB20 NF1 MCM4 TUBGCP2 SPAG16	9.46e-05	194	86	6	6553_DN
Drug	Furaltadone hydrochloride [3759-92-0]; Up 200; 11uM; PC3; HT_HG-U133A	NF1 CILP GRB7 ATP10B TUBGCP2 TRIM3	9.73e-05	195	86	6	4313_UP
Drug	CGX 0596987; Up 200; 20uM; PC3; HT_HG-U133A	FBLN1 ZBTB20 ACOT11 TUBGCP2 ADCY6 TBL1X	9.73e-05	195	86	6	6417_UP
Drug	Prenylamine lactate [69-43-2]; Down 200; 9.6uM; PC3; HT_HG-U133A	FBLN1 TRAF3 NDP IL4R ADCY6 TRIM3	9.73e-05	195	86	6	5070_DN
Drug	Indomethacin [53-86-1]; Up 200; 11.2uM; MCF7; HT_HG-U133A	MBNL2 TUBGCP2 MUC2 IL4R TRIM3 HR	1.00e-04	196	86	6	7409_UP
Drug	Panthenol (D) [81-13-0]; Down 200; 19.4uM; MCF7; HT_HG-U133A	NF1 AP2A2 IL4R JRKL TRIM3 AXIN1	1.00e-04	196	86	6	7455_DN
Drug	pioglitazone HCl; Down 200; 10uM; MCF7; HT_HG-U133A	PAOX FBLN1 NF1 AP2A2 TUBGCP2 IL4R	1.00e-04	196	86	6	6898_DN
Drug	Dropropizine (R,S) [17692-31-8]; Down 200; 17uM; MCF7; HT_HG-U133A	SCUBE2 GRB7 AGRN ADCY6 TRIM3 AXIN1	1.00e-04	196	86	6	7429_DN
Drug	Probucol [23288-49-5]; Down 200; 7.8uM; MCF7; HT_HG-U133A	PAOX NF1 AP2A2 MBNL2 TRIM3 AXIN1	1.00e-04	196	86	6	5261_DN
Drug	Zardaverine [101975-10-4]; Down 200; 15uM; MCF7; HT_HG-U133A	PAOX AP2A2 GRN AXIN1 KLHL26 VEGFB	1.00e-04	196	86	6	4793_DN
Drug	Gleevec; Up 200; 10uM; PC3; HG-U133A	FBLN1 FAT2 ZBTB20 TBL1Y MUC2 JRKL	1.00e-04	196	86	6	483_UP
Drug	Thiethylperazine malate [52239-63-1]; Up 200; 6uM; MCF7; HT_HG-U133A	PAOX NF1 MBNL2 ACOT11 TLR2 ADCY6	1.00e-04	196	86	6	6232_UP
Drug	Dicumarol [66-76-2]; Down 200; 11.8uM; MCF7; HT_HG-U133A	PAOX RELN NF1 MBNL2 TBL1Y ACOT11	1.03e-04	197	86	6	3848_DN
Drug	Aminopurine, 6-benzyl [1214-39-7]; Up 200; 17.8uM; HL60; HT_HG-U133A	FBLN1 ACOT11 ATP10B NDP DNAH7 TRIM3	1.03e-04	197	86	6	2351_UP
Drug	Ioversol [87771-40-2]; Down 200; 5uM; MCF7; HT_HG-U133A	FBLN1 NF1 MBNL2 GRN TRIM3 HR	1.03e-04	197	86	6	3365_DN
Drug	Chlormezanone [80-77-3]; Up 200; 14.6uM; PC3; HT_HG-U133A	SCUBE2 ATP10B TUBGCP2 MUC6 ADCY6 HR	1.03e-04	197	86	6	4636_UP
Drug	Guaifenesin [93-14-1]; Down 200; 20.2uM; MCF7; HT_HG-U133A	PAOX FBLN1 NF1 AP2A2 HR VEGFB	1.03e-04	197	86	6	4371_DN
Drug	3-alpha-Hydroxy-5-beta-androstan-17-one [53-42-9]; Down 200; 13.8uM; MCF7; HT_HG-U133A	FBLN1 RELN NF1 TLR2 TRIM3 VEGFB	1.03e-04	197	86	6	3639_DN
Drug	Sulfamethoxazole [723-46-6]; Up 200; 15.8uM; MCF7; HT_HG-U133A	PAOX NF1 AP2A2 ACOT11 TLR2 MUC6	1.03e-04	197	86	6	4690_UP
Drug	Praziquantel [55268-74-1]; Down 200; 12.8uM; MCF7; HT_HG-U133A	RELN NF1 GRB7 IL4R AXIN1 VEGFB	1.03e-04	197	86	6	3189_DN
Drug	Phenformin hydrochloride [834-28-6]; Down 200; 16.6uM; MCF7; HT_HG-U133A	FBLN1 FAT4 RELN AP2A2 GRB7 TRIM3	1.03e-04	197	86	6	3622_DN
Drug	Lidocaone hydrochloride [73-78-9]; Down 200; 14.8uM; HL60; HG-U133A	UBR2 ASB13 TRAF3 GNB5 MCM4 TUBGCP2	1.06e-04	198	86	6	1999_DN
Drug	Methimazole [60-56-0]; Down 200; 35uM; MCF7; HT_HG-U133A	FAT4 NF1 ACOT11 TUBGCP2 TRIM3 VEGFB	1.06e-04	198	86	6	3898_DN
Drug	Isoniazid [54-85-3]; Up 200; 29.2uM; PC3; HT_HG-U133A	PAOX MBNL2 LRP1 MUC2 DNAH7 TRIM3	1.06e-04	198	86	6	2083_UP
Drug	Halcinonide [3093-35-4]; Down 200; 8.8uM; PC3; HT_HG-U133A	HDAC9 NF1 MBNL2 MCM4 TUBGCP2 DNAH7	1.06e-04	198	86	6	3680_DN
Drug	rofecoxib; Down 200; 10uM; MCF7; HG-U133A	IVNS1ABP PAOX FBLN1 ACOT11 AXIN1 KLHL26	1.06e-04	198	86	6	205_DN
Drug	Pronethalol hydrochloride [51-02-5]; Up 200; 15uM; MCF7; HT_HG-U133A	PAOX FBLN1 NF1 ACOT11 MUC2 MUC6	1.06e-04	198	86	6	7322_UP
Drug	Benperidol [2062-84-2]; Up 200; 10.4uM; PC3; HT_HG-U133A	PAOX NF1 AP2A2 ACOT11 CAMK2A LRP1	1.06e-04	198	86	6	4196_UP
Drug	Tetramisole hydrochloride [16595-80-5]; Up 200; 16.6uM; MCF7; HT_HG-U133A	FBLN1 AP2A2 TLR2 MUC2 ADCY6 KLHL26	1.06e-04	198	86	6	2849_UP
Drug	Cefotiam hydrochloride; Up 200; 7.2uM; PC3; HT_HG-U133A	PAOX ZBTB20 NF1 AP2A2 ACOT11 TNN	1.06e-04	198	86	6	6762_UP
Drug	Hexamethonium dibromide dihydrate [55-97-0]; Down 200; 10uM; MCF7; HT_HG-U133A	SCUBE2 AP2A2 NUMB TUBGCP2 KLHL26 VEGFB	1.06e-04	198	86	6	1482_DN
Drug	Disopyramide [3737-09-5]; Up 200; 11.8uM; MCF7; HT_HG-U133A	PAOX TRAF3 NF1 AP2A2 AGRN MUC6	1.06e-04	198	86	6	7035_UP
Drug	Guanethidine sulfate [60-02-6]; Up 200; 13.4uM; HL60; HG-U133A	ZBTB20 VILL ACOT11 GNB5 MCM4 AGRN	1.09e-04	199	86	6	1554_UP
Drug	Butirosin disulfate salt [51022-98-1]; Up 200; 5.4uM; MCF7; HT_HG-U133A	FBLN1 VILL TBL1Y TLR2 MUC6 HR	1.09e-04	199	86	6	6080_UP
Drug	Neomycin sulfate [1405-10-3]; Down 200; 4.2uM; HL60; HG-U133A	ASB13 MCM4 ATP10B IL4R JRKL TBL1X	1.09e-04	199	86	6	1383_DN
Drug	Crotamiton [483-63-6]; Up 200; 19.6uM; PC3; HT_HG-U133A	NF1 AP2A2 ACOT11 TUBGCP2 ADCY6 HR	1.09e-04	199	86	6	4628_UP
Drug	PHA-00851261E [724719-49-7]; Up 200; 10uM; PC3; HT_HG-U133A	SCUBE2 AP2A2 ACOT11 ATP10B MUC2 TRIM3	1.12e-04	200	86	6	3773_UP
Drug	Methyldopa (L,-) [555-30-6]; Up 200; 19uM; PC3; HT_HG-U133A	PAOX ACOT11 TLR2 MUC2 ADCY6 TRIM3	1.12e-04	200	86	6	4677_UP
Drug	Oxytetracycline dihydrate [6153-64-6]; Down 200; 8uM; PC3; HT_HG-U133A	IVNS1ABP FBLN1 FAT4 MBNL2 TUBGCP2 IL4R	1.12e-04	200	86	6	5772_DN
Drug	Chr 5	RELN NF1 GCK AGRN ADH1C	1.12e-04	125	86	5	CID006448119
Drug	loxoprofen	MUC2 NOS2	1.40e-04	5	86	2	ctd:C040656
Drug	AC1L9828	PRPS2 PRPS1	1.40e-04	5	86	2	CID000439794
Drug	benzylidenemalononitrile	RHBDF1 GRN NOS2	1.43e-04	27	86	3	CID000017608
Drug	prenalterol	GRN ADCY5 ADCY6	1.59e-04	28	86	3	CID000042396
Drug	Nocloprostum	NOS2 ADCY5 ADCY6	1.59e-04	28	86	3	CID006435380
Disease	sensory system disease (implicated_via_orthology)	TBL1Y TBL1XR1 TBL1X	2.15e-08	3	83	3	DOID:0050155 (implicated_via_orthology)
Disease	adult onset asthma	HDAC9 LRP1 MUC2 TBL1XR1 IL4R	2.13e-05	118	83	5	EFO_1002011
Disease	Retinal Neovascularization	NF1 NDP	2.34e-05	3	83	2	C0035320
Disease	Congenital myasthenic syndrome ib	GRN AGRN	2.34e-05	3	83	2	C1850792
Disease	cholangiocarcinoma (is_marker_for)	MUC2 NOS2 MUC6 IL4R	3.25e-05	64	83	4	DOID:4947 (is_marker_for)
Disease	asthma	HDAC9 TRAF3 AP2A2 RBBP8 LRP1 GRB7 ATP10B MUC2 TBL1XR1 IL4R	4.90e-05	751	83	10	MONDO_0004979
Disease	X-24020 measurement	PAOX TUBGCP2	7.77e-05	5	83	2	EFO_0022128
Disease	mucositis (biomarker_via_orthology)	MUC2 NOS2	7.77e-05	5	83	2	DOID:0080178 (biomarker_via_orthology)
Disease	mucinous adenocarcinoma (is_marker_for)	MUC2 MUC6	7.77e-05	5	83	2	DOID:3030 (is_marker_for)
Disease	primary progressive multiple sclerosis (is_implicated_in)	GRN IL4R	7.77e-05	5	83	2	DOID:0050784 (is_implicated_in)
Disease	Mental Depression	HDAC9 RELN CAMK2A GRN NOS2 ADCY5	8.32e-05	254	83	6	C0011570
Disease	acne (is_implicated_in)	TLR2 IL4R	1.16e-04	6	83	2	DOID:6543 (is_implicated_in)
Disease	Inhalant adrenergic use measurement	ATP10B MUC2 TBL1XR1 IL4R	1.59e-04	96	83	4	EFO_0009941
Disease	Colorectal Carcinoma	AMER2 NF1 ABCA13 TLR2 GNB5 LRP1 CUBN HR PRPS1	1.59e-04	702	83	9	C0009402
Disease	Depressive disorder	HDAC9 RELN CAMK2A GRN NOS2 ADCY5	1.68e-04	289	83	6	C0011581
Disease	alcohol use disorder measurement	METAP1 ZBTB20 NF1 TCF20 ADH1C	3.51e-04	214	83	5	EFO_0009458
Disease	Acute Cerebrovascular Accidents	PAOX HDAC9 NOS2	4.80e-04	54	83	3	C0751956
Disease	dementia (is_implicated_in)	GRN NOS2	5.07e-04	12	83	2	DOID:1307 (is_implicated_in)
Disease	autistic disorder (is_marker_for)	RELN GRN	5.07e-04	12	83	2	DOID:12849 (is_marker_for)
Disease	alkaline phosphatase measurement	PRMT6 METAP1 ZBTB20 NF1 GCK LTBP3 CLUH ADCY5 AXIN1 ADH1C	5.56e-04	1015	83	10	EFO_0004533
Disease	aspartate aminotransferase measurement, serum alanine aminotransferase measurement, low density lipoprotein triglyceride measurement, body fat percentage, high density lipoprotein cholesterol measurement, sex hormone-binding globulin measurement	PRMT6 RELN TRAF3 LRP1 ADCY5 HR	5.74e-04	364	83	6	EFO_0004612, EFO_0004696, EFO_0004735, EFO_0004736, EFO_0007800, EFO_0009946
Disease	lung disease (implicated_via_orthology)	TLR2 NOS2	5.98e-04	13	83	2	DOID:850 (implicated_via_orthology)
Disease	Cerebrovascular accident	PAOX HDAC9 NOS2	7.20e-04	62	83	3	C0038454
Disease	Unipolar Depression	HDAC9 RELN CAMK2A LRP1 ADCY5	8.33e-04	259	83	5	C0041696
Disease	asthma (is_implicated_in)	TLR2 MUC2 NOS2 IL4R	1.02e-03	157	83	4	DOID:2841 (is_implicated_in)
Disease	Moyamoya Disease	ATP7A NF1	1.03e-03	17	83	2	C0026654
Disease	perinatal necrotizing enterocolitis (biomarker_via_orthology)	TLR2 MUC2	1.03e-03	17	83	2	DOID:8677 (biomarker_via_orthology)
Disease	bipolar disorder (is_marker_for)	RELN GRN	1.30e-03	19	83	2	DOID:3312 (is_marker_for)
Disease	sucrose liking measurement	RELN CDH20	1.44e-03	20	83	2	EFO_0010157
Disease	Osteoarthritis of hip	HDAC9 LTBP3	1.44e-03	20	83	2	C0029410
Disease	alcohol dependence	MBNL2 TNN MUC2 ADH1C	1.80e-03	183	83	4	MONDO_0007079
Disease	BMI-adjusted fasting blood glucose measurement	GCK ADCY5	1.90e-03	23	83	2	EFO_0008036
Disease	descending aortic diameter	HDAC9 ZBTB20 LRP1	1.98e-03	88	83	3	EFO_0021788
Disease	fasting blood glucose measurement, HOMA-B, fasting blood insulin measurement	GCK ADCY5	2.25e-03	25	83	2	EFO_0004465, EFO_0004466, EFO_0004469
Disease	age of onset of childhood onset asthma	TRAF3 TBL1XR1 IL4R	2.25e-03	92	83	3	OBA_2001015
Disease	middle cerebral artery infarction (biomarker_via_orthology)	HDAC9 CAMK2A NOS2	2.32e-03	93	83	3	DOID:3525 (biomarker_via_orthology)
Disease	acute necrotizing pancreatitis (biomarker_via_orthology)	TLR2 NOS2	2.43e-03	26	83	2	DOID:0080998 (biomarker_via_orthology)
Disease	atopic dermatitis (is_implicated_in)	TLR2 IL4R	2.43e-03	26	83	2	DOID:3310 (is_implicated_in)
Disease	body fat percentage	PRMT6 RELN TRAF3 LRP1 ADCY5 HR	2.56e-03	488	83	6	EFO_0007800
Disease	glucose tolerance test	GCK ADCY5	2.62e-03	27	83	2	EFO_0004307
Disease	apolipoprotein A 1 measurement	METAP1 TRAF3 LRP1 SPG11 ADCY5 NUP205 ADH1C VEGFB	2.66e-03	848	83	8	EFO_0004614

Protein segments in the cluster

Peptide	Gene	Start	Entry
TGTLAADMDLHCDCA	AMER2	36	Q8N7J2
AGLCDRCAVTEEHMR	RBBP8	86	Q99708
LPEARADHAHCCVEM	ADCY6	436	O43306
MVAAGICRSDEHVVS	ADH1C	41	P00326
LHEACMSGSSECVRL	ASB13	121	Q8WXK3
AHTVGDVKCDMEVSC	GRN	276	P28799
SHTGRTCEMVVACLG	FAT4	4456	Q6V0I7
RCVEESGSAHCVCPM	AGRN	911	O00468
GCAAVLTSHSMEECE	ABCA13	4906	Q86UQ4
AERHAGCPCVTASMD	ACOT11	81	Q8WXI4
CAGVAEVTSMARILH	DNHD1	2211	Q96M86
LPEARADHAHCCVEM	ADCY5	526	O95622
SGSVCQDLCELHMVE	DIPK1B	76	Q5VUD6
SVLHEQRCGTECMRD	ATP10B	1396	O94823
ALHCIASVGSREMAE	AP2A2	131	O94973
RGMTCASCVHKIESS	ATP7A	571	Q04656
CSTCAEIMATEGLHE	GNB5	36	O14775
CESVSTRAAHMCSAG	GCK	371	P35557
ALMEVVCRDACDGHE	NUP205	1476	Q92621
VCRDACDGHEIGRML	NUP205	1481	Q92621
SCSTAREMFEHICRH	NOS2	216	P35228
AHCISEDCRMGAGIA	OARD1	31	Q9Y530
CQVCAHTTRVEMDRG	MCM4	306	P33991
VCAETHCSMLLRTGT	MUC6	586	Q6W4X9
MAAVETRVCETDGCS	METAP1	1	P53582
FCDVRLQVCGHEMLA	IVNS1ABP	31	Q9Y6Y0
ALISKRMEGHCEAEC	DEFB107A	31	Q8IZN7
RMEGHCEAECLTFEV	DEFB107A	36	Q8IZN7
ACAHGMLAEDGASCR	LRP1	2181	Q07954
EECTQEAGHAACSLM	HR	646	O43593
CEMEARGCSEGHCLV	FAT2	4021	Q9NYQ8
CEHMGIARLACASIK	OR52E6	181	Q96RD3
EVSSLCEEHRMDGCF	MUC2	316	Q02817
SDCEHGMASVISRLD	TUBGCP2	846	Q9BSJ2
GHKSIEERVTIMCCA	JRKL	201	Q9Y4A0
CEHMAVVKLACGDTR	OR52P1	181	Q8NH57
VEVAAGATARHVCEM	GRB7	116	Q14451
SCRREEVDACATAVM	IL20RB	286	Q6UXL0
VGCEATSCGDLHSVM	RELN	3126	P78509
VLLEACCADGHRMAT	FBLN1	31	P23142
SVARCVHGICEDLMR	CUBN	221	O60494
MRTICIDGGHAVDAA	GAL3ST1	341	Q99999
VHCMDGRAASAVAVC	GAK	506	O14976
GAGCVCHLLMDDVVS	IL4R	81	P24394
FRELTEMEVGCSHTC	KLHL26	341	Q53HC5
EMEVGCSHTCVAVLD	KLHL26	346	Q53HC5
TIQVCSCDDDGHVMS	CDH20	591	Q9HBT6
DHCALVRSGCAFMVH	COG3	361	Q96JB2
VRSGCAFMVHVCQDE	COG3	366	Q96JB2
CVDMGCAGLRDAHEE	AXIN1	451	O15169
IRDGCIDMCKSFHTS	DNAH7	2526	Q8WXX0
CEMCYTTHGLELTRV	REXO1L1P	506	Q8IX06
ESHCGSLMERDITNC	CCDC66	626	A2RUB6
CLEGFATRCLMGHSE	PRMT6	221	Q96LA8
GSLDLCHMDLTREVC	DRC7	211	Q8IY82
HRDIDECMLFGSEIC	LTBP3	991	Q9NS15
GMECQESALRITKHC	MBNL2	341	Q5VZF2
MSRHEGVSCDACLKG	KCMF1	1	Q9P0J7
HSSGAARMAVGCVIE	HDAC9	746	Q9UKV0
TCIHRSEEGLSCMNK	SCUBE2	166	Q9NQ36
ECCVSGTHSMDLVAL	PAOX	191	Q6QHF9
CEHMAVVRLACGDTS	OR52K1	181	Q8NGK4
CEHMAVVRLACGDTS	OR52K2	181	Q8NGK3
CHCFMAVKDTGERLS	NUMB	141	P49757
REACHCEEVKMTVAS	FAN1	296	Q9Y2M0
MSVCHGEEAVCSAGA	SYPL2	191	Q5VXT5
QEHLCAMTGVDCCIS	SMG1	1126	Q96Q15
ATLCSQVHCMDDVCG	RHBDF1	626	Q96CC6
MHCRDCALVTSSGHL	ST6GALNAC5	91	Q9BVH7
TVASCMHRQETVDCL	CAMK2A	276	Q9UQM7
STDMCIHVCKLGQDR	TBL1XR1	326	Q9BZK7
MVSLCSEASEEGQHC	CILP	181	O75339
VLMDREDTCHRTCFS	CLUH	76	O75153
IALCFSMCREIGENH	SPG11	2221	Q96JI7
ASCSTDMCIHVCRLG	TBL1X	386	O60907
TECGHRFCESCMAAL	TRAF3	66	Q13114
ECVRGVCQCHEDFMS	TNN	211	Q9UQP3
AVIDCVLLECGHMVT	RNF34	331	Q969K3
DMADTCGTICHAADK	PRPS2	221	P11908
RGHMIASCDACGVTK	SPAG16	531	Q8N0X2
EAVLVAMSCFRHLCE	NF1	701	P21359
IAREMKCSHCQEAGA	TCF20	1881	Q9UGU0
STDMCIHVCRLGCDH	TBL1Y	336	Q9BQ87
ECSSHMGCLVLAEVG	VILL	616	O15195
SSKMVLLARCEGHCS	NDP	56	Q00604
DCDISCKGMTERIHS	ZBTB20	66	Q9HC78
LGEMSLEEHSQCECR	VEGFB	111	P49765
EECGKAFRHTSSLCM	ZNF664	146	Q8N3J9
DMADTCGTICHAADK	PRPS1	221	P60891
CVLCMECFLGSIHRD	UBR2	121	Q8IWV8
SVSECHRTALVSGMC	TLR2	581	O60603
ETAMCGECRAGEHRE	TRIM3	131	O75382