Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctiontranscription coactivator activity

MAML1 NCOA2 KMT2C KAT2A RIPK3 GSDMD

6.53e-05303466GO:0003713
GeneOntologyMolecularFunctiontranscription coregulator activity

MAML1 NCOA2 KMT2C KAT2A RIPK3 SF1 GSDMD

2.78e-04562467GO:0003712
GeneOntologyCellularComponentside of membrane

EPN3 CD44 MUC16 ROBO4 GNAS DTNA IL6R MTSS1 PRSS21

1.03e-04875469GO:0098552
GeneOntologyCellularComponentcanonical inflammasome complex

NLRP1 GSDMD

7.09e-0418462GO:0061702
GeneOntologyCellularComponentcytoplasmic side of plasma membrane

EPN3 GNAS DTNA MTSS1

7.25e-04185464GO:0009898
DomainPAS

NCOA2 EPAS1

1.57e-0325442PF00989
DomainPAS_fold

NCOA2 EPAS1

1.57e-0325442IPR013767
DomainPAC

NCOA2 EPAS1

1.70e-0326442IPR001610
DomainPAC

NCOA2 EPAS1

1.70e-0326442SM00086
DomainPAS

NCOA2 EPAS1

2.57e-0332442SM00091
DomainPAS

NCOA2 EPAS1

2.90e-0334442IPR000014
DomainGPS

PKD1L2 ADGRD1

2.90e-0334442SM00303
DomainPAS

NCOA2 EPAS1

2.90e-0334442PS50112
DomainGPS

PKD1L2 ADGRD1

3.07e-0335442PF01825
DomainGPS

PKD1L2 ADGRD1

3.25e-0336442PS50221
DomainGPS

PKD1L2 ADGRD1

3.43e-0337442IPR000203
DomainVWA

CACNA2D4 ITIH2

7.71e-0356442PF00092
Pubmed

SHAP potentiates the CD44-mediated leukocyte adhesion to the hyaluronan substratum.

CD44 ITIH2

1.79e-06247216702221
Pubmed

CD44 Interacts with HIF-2α to Modulate the Hypoxic Phenotype of Perinecrotic and Perivascular Glioma Cells.

CD44 EPAS1

1.79e-06247228813675
Pubmed

TSC2 loss in lymphangioleiomyomatosis cells correlated with expression of CD44v6, a molecular determinant of metastasis.

CD44 TSC2

1.79e-06247217975002
Pubmed

RIPK3 collaborates with GSDMD to drive tissue injury in lethal polymicrobial sepsis.

RIPK3 GSDMD

1.79e-06247232152555
Pubmed

Acquired Cystic Kidney Disease-associated Renal Cell Carcinoma (ACKD-RCC) Harbor Recurrent Mutations in KMT2C and TSC2 Genes.

KMT2C TSC2

1.79e-06247232604168
Pubmed

Dispensable roles of Gsdmd and Ripk3 in sustaining IL-1β production and chronic inflammation in Th17-mediated autoimmune arthritis.

RIPK3 GSDMD

1.79e-06247234548542
Pubmed

Receptors for hyaluronic acid and poliovirus: a combinatorial role in glioma invasion?

CD44 PVR

1.79e-06247222363471
Pubmed

Prognostic significance of CA 125, CD44, and epithelial membrane antigen in renal cell carcinoma.

CD44 MUC16

5.36e-06347212893366
Pubmed

Requirement for CD44 in homing and engraftment of BCR-ABL-expressing leukemic stem cells.

CD44 BCR

5.36e-06347216998483
Pubmed

RIP3 antagonizes a TSC2-mediated pro-survival pathway in glioblastoma cell death.

TSC2 RIPK3

5.36e-06347227984090
Pubmed

The Inflammasome-Dependent Dysfunction and Death of Retinal Ganglion Cells after Repetitive Intraocular Pressure Spikes.

NLRP1 GSDMD

1.78e-05547237998361
Pubmed

The NADPH oxidase subunit p22phox inhibits the function of the tumor suppressor protein tuberin.

TSC2 EPAS1

1.78e-05547220304964
Pubmed

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death.

RIPK3 GSDMD

1.78e-05547226375003
Pubmed

Pathogen blockade of TAK1 triggers caspase-8-dependent cleavage of gasdermin D and cell death.

RIPK3 GSDMD

1.78e-05547230361383
Pubmed

Gasdermin D is an executor of pyroptosis and required for interleukin-1β secretion.

NLRP1 GSDMD

1.78e-05547226611636
Pubmed

Expression of Muc19/Smgc gene products during murine sublingual gland development: cytodifferentiation and maturation of salivary mucous cells.

MUC16 MUC6

2.67e-05647219110483
Pubmed

Gasdermin E permits interleukin-1 beta release in distinct sublytic and pyroptotic phases.

NLRP1 GSDMD

2.67e-05647233852854
Pubmed

ZBP1 promotes fungi-induced inflammasome activation and pyroptosis, apoptosis, and necroptosis (PANoptosis).

RIPK3 GSDMD

2.67e-05647233109609
Pubmed

Myeloid OTULIN deficiency couples RIPK3-dependent cell death to Nlrp3 inflammasome activation and IL-1β secretion.

RIPK3 GSDMD

3.74e-05747238000038
Pubmed

Gasdermin-D and Caspase-7 are the key Caspase-1/8 substrates downstream of the NAIP5/NLRC4 inflammasome required for restriction of Legionella pneumophila.

RIPK3 GSDMD

3.74e-05747231251782
Pubmed

Genetic targeting of Card19 is linked to disrupted NINJ1 expression, impaired cell lysis, and increased susceptibility to Yersinia infection.

RIPK3 GSDMD

4.98e-05847234648590
Pubmed

cFLIPL protects macrophages from LPS-induced pyroptosis via inhibition of complex II formation.

RIPK3 GSDMD

4.98e-05847232193329
Pubmed

NAIP-NLRC4 Inflammasomes Coordinate Intestinal Epithelial Cell Expulsion with Eicosanoid and IL-18 Release via Activation of Caspase-1 and -8.

RIPK3 GSDMD

4.98e-05847228410991
Pubmed

A Two-Cell Model for IL-1β Release Mediated by Death-Receptor Signaling.

RIPK3 GSDMD

6.40e-05947232268091
Pubmed

An Apoptotic Caspase Network Safeguards Cell Death Induction in Pyroptotic Macrophages.

RIPK3 GSDMD

6.40e-05947232726624
Pubmed

New nomenclature for chromatin-modifying enzymes.

NCOA2 KMT2C KAT2A

6.43e-055747318022353
Pubmed

A transcriptional inhibitor targeted by the atypical orphan nuclear receptor SHP.

NCOA2 KAT2A

7.99e-051047211964378
Pubmed

BAX/BAK-Induced Apoptosis Results in Caspase-8-Dependent IL-1β Maturation in Macrophages.

RIPK3 GSDMD

7.99e-051047230485805
Pubmed

Caspase-6 Is a Key Regulator of Innate Immunity, Inflammasome Activation, and Host Defense.

RIPK3 GSDMD

9.75e-051147232298652
Pubmed

Adrenocorticotropic hormone-mediated signaling cascades coordinate a cyclic pattern of steroidogenic factor 1-dependent transcriptional activation.

NCOA2 KAT2A

9.75e-051147216109736
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

EPN3 MAML1 KMT2C TSC2 KAT2A REPS1 SNAPC4 BCR

1.06e-04110547835748872
Pubmed

Apoptosis of intestinal epithelial cells restricts Clostridium difficile infection in a model of pseudomembranous colitis.

RIPK3 GSDMD

1.17e-041247230451870
Pubmed

ZBP1 promotes LPS-induced cell death and IL-1β release via RHIM-mediated interactions with RIPK1.

RIPK3 GSDMD

1.38e-041347233397971
Pubmed

Impaired NLRP3 inflammasome activation/pyroptosis leads to robust inflammatory cell death via caspase-8/RIPK3 during coronavirus infection.

RIPK3 GSDMD

1.38e-041347232763970
Pubmed

Activity of caspase-8 determines plasticity between cell death pathways.

RIPK3 GSDMD

1.61e-041447231723262
Pubmed

Activating signal cointegrator 2 belongs to a novel steady-state complex that contains a subset of trithorax group proteins.

NCOA2 KMT2C

1.61e-041447212482968
Pubmed

T cells instruct myeloid cells to produce inflammasome-independent IL-1β and cause autoimmunity.

RIPK3 GSDMD

1.61e-041447231848486
Pubmed

Enzymatic nucleosome acetylation selectively affects activity of histone methyltransferases in vitro.

KMT2C KAT2A

1.86e-041547235907431
Pubmed

Diversified Application of Barcoded PLATO (PLATO-BC) Platform for Identification of Protein Interactions.

EPN3 UBAC1

1.86e-041547231494268
Pubmed

The Mitochondrial Apoptotic Effectors BAX/BAK Activate Caspase-3 and -7 to Trigger NLRP3 Inflammasome and Caspase-8 Driven IL-1β Activation.

RIPK3 GSDMD

1.86e-041547230485804
Pubmed

Mucin gene expression in human laryngeal epithelia: effect of laryngopharyngeal reflux.

MUC16 MUC6

2.70e-041847218834073
Pubmed

A unique death pathway keeps RIPK1 D325A mutant mice in check at embryonic day 10.5.

RIPK3 GSDMD

2.70e-041847234437534
Pubmed

Identification and selected reaction monitoring (SRM) quantification of endocytosis factors associated with Numb.

REPS1 BCR

2.70e-041847223211419
Pubmed

Nuclear receptor-coregulator interaction profiling identifies TRIP3 as a novel peroxisome proliferator-activated receptor gamma cofactor.

NCOA2 KAT2A

3.69e-042147219596656
Pubmed

Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

CD44 ROBO4 ITIH2 PVR

4.05e-0425747416335952
Pubmed

Characterization of definitive lymphohematopoietic stem cells in the day 9 murine yolk sac.

CD44 IL6R

4.06e-04224729324354
Pubmed

Interferon-γ primes macrophages for pathogen ligand-induced killing via a caspase-8 and mitochondrial cell death pathway.

RIPK3 GSDMD

5.26e-042547235139355
Pubmed

Induction of Gastric Cancer by Successive Oncogenic Activation in the Corpus.

CD44 MUC6

5.26e-042547234391772
Pubmed

ZBP1/DAI is an innate sensor of influenza virus triggering the NLRP3 inflammasome and programmed cell death pathways.

RIPK3 GSDMD

5.26e-042547227917412
Pubmed

Synergism of TNF-α and IFN-γ Triggers Inflammatory Cell Death, Tissue Damage, and Mortality in SARS-CoV-2 Infection and Cytokine Shock Syndromes.

RIPK3 GSDMD

7.09e-042947233278357
Pubmed

Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.

NCOA2 KMT2C GNAS BCR DTNA IL6R ADGRD1 PVR

7.85e-04148947828611215
Pubmed

Comparative interactome analysis of α-arrestin families in human and Drosophila.

TSC2 GNAS BCR DTNA

8.46e-0431347438270169
Pubmed

The CARM1-p300-c-Myc-Max (CPCM) transcriptional complex regulates the expression of CUL4A/4B and affects the stability of CRL4 E3 ligases in colorectal cancer.

KAT2A BCR

9.19e-043347232140074
Pubmed

Joint influence of small-effect genetic variants on human longevity.

TSC2 ADGRD1

9.75e-043447220834067
Pubmed

The Eyes Absent family members EYA4 and EYA1 promote PLK1 activation and successful mitosis through tyrosine dephosphorylation.

MAML1 NCOA2 SF1

1.15e-0315247338360978
Pubmed

Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.

MAML1 NCOA2 GNAS BCR DTNA

1.16e-0358847538580884
Pubmed

mTORC1-induced retinal progenitor cell overproliferation leads to accelerated mitotic aging and degeneration of descendent Müller glia.

TSC2 EPAS1

1.35e-034047234677125
CytobandEnsembl 112 genes in cytogenetic band chr7q36

KMT2C ATG9B FASTK

5.91e-04159473chr7q36
GeneFamilyZinc fingers ZZ-type|Lysine acetyltransferases

NCOA2 KAT2A

4.86e-0417352486
GeneFamilyCD molecules|Mucins

MUC16 MUC6

7.47e-0421352648
GeneFamilyGlycosyltransferase family 6|Blood group antigens

CD44 ICAM4

2.32e-0337352454
GeneFamilyImmunoglobulin like domain containing

IL6R PVR ICAM4

6.10e-03193353594
GeneFamilyADAM metallopeptidase domain containing|CD molecules

CD44 IL6R PVR ICAM4

6.82e-03394354471
CoexpressionGSE360_L_DONOVANI_VS_B_MALAYI_HIGH_DOSE_DC_DN

TSC2 DLEC1 KAT2A FASTK MUC6 UBAC1

1.47e-06199476M5201
ToppCellPND10-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

MUC16 CCDC80 B3GNT7 MUC6 ADGRD1

8.97e-071674757abc785e688a384672d7fb5a62d32538fe7e5a51
ToppCellPND10-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial-Mesothelial_mature|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

MUC16 CCDC80 B3GNT7 MUC6 ADGRD1

8.97e-07167475d50311b1f66f143bae4c4cf50e2e9b13c85d6920
ToppCellStriatum-Endothelial-ENDOTHELIAL_TIP|Striatum / BrainAtlas - Mouse McCarroll V32

ANKK1 NLRP1 ITIH2 KCNG4

5.36e-06109474a84a4a3ac19692e5595b9820d49e12ae336f4bbf
ToppCellStriatum-Endothelial-ENDOTHELIAL_TIP-Dcn_1-Dcn_1_1-Endothelial_Tip.Dcn_(Dcn)-|Striatum / BrainAtlas - Mouse McCarroll V32

ANKK1 NLRP1 ITIH2 KCNG4

5.36e-06109474f7d7b67f7585f2ae0ac905bcf3980264cf9234b8
ToppCellStriatum-Endothelial-ENDOTHELIAL_TIP-Dcn_1-Dcn_1_1|Striatum / BrainAtlas - Mouse McCarroll V32

ANKK1 NLRP1 ITIH2 KCNG4

5.36e-06109474f007fa3dc92d6c8543585e47ccec218263b3266e
ToppCellStriatum-Endothelial-ENDOTHELIAL_TIP-Dcn_1|Striatum / BrainAtlas - Mouse McCarroll V32

ANKK1 NLRP1 ITIH2 KCNG4

5.36e-06109474f4b9fe5335cabe48a5fae7ec51bab0d7bdb17321
ToppCellStriatum-Endothelial-ENDOTHELIAL_TIP-Dcn_1-Dcn_1_1-Endothelial_Tip.Dcn_(Dcn)|Striatum / BrainAtlas - Mouse McCarroll V32

ANKK1 NLRP1 ITIH2 KCNG4

5.36e-061094748460683529759585bd363d10a16ee13af2bd4e28
ToppCellfacs-Aorta-Heart-24m-Mesenchymal-fibrocyte|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CD44 PKD1L2 IL6R PSD4

1.70e-05146474d8d24851e8d8d90795a6f9378418f209200d55b1
ToppCelldroplet-Kidney-nan-18m-Myeloid-nan|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CD44 RIPK3 GSDMD IL6R

2.26e-05157474eb64a4e89843895d16015c7d51805f164ed7ea5b
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Ascending_Vasa_Recta_Endothelial_Cell_prolif|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ROBO4 NLRP1 DTNA EPAS1

2.75e-051654746a621b300442c52adfc15b61d3a6d3a3cb00099f
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-Adaptive_/_Maladaptive_/_Repairing_Fibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

CD44 CCDC80 LTBP2 ADGRD1

2.95e-051684744b2d29a7843bf45922038c093ca7ec0600756adc
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

CD44 CCDC80 LTBP2 ADGRD1

3.16e-051714745d31fc9b60329d4ae3c77e4ca679359d9314397d
ToppCellfacs-Kidney-nan-24m-Mesenchymal-kidney_interstitial_fibroblast|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CCDC80 RIPK3 ADGRD1 PSD4

3.95e-05181474c7f5aedcb74c21fb587a95a16d700e2a38a380ee
ToppCellfacs-Kidney-nan-24m-Mesenchymal-kidney_interstitial_fibroblast|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CCDC80 RIPK3 ADGRD1 PSD4

3.95e-051814740ec9621a078d004bbd25a587757d24b5cf162959
ToppCellPCW_13-14-Mesenchymal-Mesenchymal_fibroblastic-mes_Arw_fibro_(16)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

CCDC80 LTBP2 DTNA ADGRD1

4.30e-051854747dcdc009c5681ee05dd18968f7e85c3403fe34af
ToppCellPCW_10-12-Mesenchymal-Mesenchymal_fibroblastic-mes_immature_COL13A1^pos_fibro2_(5)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

CCDC80 LTBP2 DTNA ADGRD1

4.30e-051854749f19f04fc4d97dfc2dd78cde77b515f1cb5d51ec
ToppCellPCW_10-12-Mesenchymal-Mesenchymal_fibroblastic-mes_Arw_fibro_(16)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

CCDC80 LTBP2 DTNA ADGRD1

4.48e-051874745258674d0346e5c51a4b965efcdc1790c970845d
ToppCellPCW_13-14-Mesenchymal-Mesenchymal_fibroblastic-mes_immature_COL13A1^pos_fibro2_(5)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

CCDC80 LTBP2 DTNA ADGRD1

4.48e-0518747413731298bc562ec29582f5da1b4c97261284f6f1
ToppCelldroplet-Lung-30m-Hematologic-myeloid-alveolar_macrophage-alveolar_macrophage|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

CD44 CCDC80 B3GNT7 MTSS1

4.67e-0518947498f517af255ef234eefc3ed7e6c1d63331ab8af0
ToppCelldroplet-Lung-30m-Hematologic-myeloid-alveolar_macrophage|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

CD44 CCDC80 B3GNT7 MTSS1

4.67e-05189474f7e9b6e6a4de297b660a5b6c9a62f860c147185e
ToppCellILEUM-non-inflamed-(7)_Endothelial_cell-(7)_Lymphatics|(7)_Endothelial_cell / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

CCDC80 B3GNT7 GNAS MTSS1

4.77e-051904749ce301841ce9486701fa28eb2a9929e35d476878
ToppCellpdx-Tumor_cells-T8|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)

CACNA2D4 IL6R ADGRD1 MTSS1

4.77e-05190474b05db0de9b6ae01dd30074453f7de44f7397631e
ToppCellE18.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-Pericyte-Pericyte_mature|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CCDC80 LTBP2 GNAS BCR

4.77e-05190474951e067d14412db67dc3babcdf61e41717d7b429
ToppCellfacs-Trachea-3m-Endothelial-endothelial_cell_of_trachea-tracheal_endothelial_cell-tracheal_endothelial_cell_l10|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ROBO4 ATG9B BCR EPAS1

4.77e-051904742655df8c0883dd811fa7617301f9c4b0a4dd55ec
ToppCellE15.5-Mesenchymal-developing_mesenchymal_cell-mesenchymal_myogenic_precursor_(Axin2+)|E15.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

CCDC80 GNAS RIPK3 EPAS1

4.77e-0519047484fbd5664ec886120963d4f50dfa1fd1851d36c1
ToppCellControl-Myeloid-Macrophage|Myeloid / Disease state, Lineage and Cell class

CD44 PLA2G7 IL6R MTSS1

5.07e-051934742a6d531abd34df20941cf3dac4fdfb1621a1bde6
ToppCellPND01-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-Pericyte|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CCDC80 LTBP2 GNAS BCR

5.27e-051954744a5d2f62aad5817d077177bf8b4ff0e46d3b8d97
ToppCellPND01-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-Pericyte-Pericyte_mature|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CCDC80 LTBP2 GNAS BCR

5.27e-051954747a32a8535c29b819dacba901d0658280a2631c94
ToppCell10x_3'_v2v3-Neoplastic-Differentiated-like-AC-like|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

CCDC80 NLRP1 GNAS DTNA

5.71e-051994746723287924750a2247a07ab6e561066a97b09771
ToppCellIPF-Myeloid-Macrophage|Myeloid / Disease state, Lineage and Cell class

CD44 PLA2G7 IL6R MTSS1

5.71e-051994743c2b362d5e824e1a04830e70352f8818de984174
ToppCellLPS_only-Endothelial-Endothelial-Activated_Gen_Cap|LPS_only / Treatment groups by lineage, cell group, cell type

ROBO4 BCR GSDMD EPAS1

5.82e-052004746f531a418ff25b59a543800cf4bce7b72404ce08
ToppCell10x_3'_v2v3-Neoplastic|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

CCDC80 NLRP1 GNAS DTNA

5.82e-05200474e9c7d7cb5fa63fc92aa91d02ae8bd05438d465bc
ToppCellThalamus-Endothelial-ENDOTHELIAL_TIP-Dcn_1-Dcn_1_1-Endothelial_Tip.Dcn_(Dcn)|Thalamus / BrainAtlas - Mouse McCarroll V32

NLRP1 MUC6 ITIH2

1.26e-0492473bbaf5a131f860198840e34843b7c841bcc98d9c4
ToppCellThalamus-Endothelial-ENDOTHELIAL_TIP-Dcn_1-Dcn_1_1-Endothelial_Tip.Dcn_(Dcn)-|Thalamus / BrainAtlas - Mouse McCarroll V32

NLRP1 MUC6 ITIH2

1.26e-0492473e6aa2b8ca9235a7291ee41d976b886fec185835d
ToppCellPosterior_cortex-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Inhibitory_Neuron.Gad1Gad2-Th.Nr4a2_(Neuron.Gad1Gad2-Th.Nr4a2)--|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

LTBP2 SLC18A1 PROSER3

1.34e-0494473c73e99890431750b74f984de5c82e33533ab708b
ToppCellPosterior_cortex-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Inhibitory_Neuron.Gad1Gad2-Th.Nr4a2_(Neuron.Gad1Gad2-Th.Nr4a2)-|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

LTBP2 SLC18A1 PROSER3

1.34e-04944731bda61101f45f5c4a68453087b880fdc6d9acfca
ToppCellPosterior_cortex-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Inhibitory_Neuron.Gad1Gad2-Th.Nr4a2_(Neuron.Gad1Gad2-Th.Nr4a2)|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

LTBP2 SLC18A1 PROSER3

1.34e-04944739664f74bc0168c92fb8a68cad628323c476f6103
ToppCellTCGA-Breast-Primary_Tumor-Breast_Carcinoma-Papillary_Carcinoma-8|TCGA-Breast / Sample_Type by Project: Shred V9

DLEC1 SLC18A1 PRSS21

1.71e-04102473631b22bd588e5259873b4253435a6e6b3cced346
ToppCelldroplet-Tongue-nan-24m-Epithelial-nan|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CCDC80 ATG9B PSD4

1.81e-04104473a4ae3cae44aac8b6e0d14896f9acab44f0cc97c4
ToppCellLPS-IL1RA-Epithelial_alveolar-Mes-Like-AT1-AT2|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

EPN3 DLEC1 ICAM4

3.33e-04128473082b3dc312b033c9b21cf73499009a1dc049ee2b
ToppCell10x5'-Lung-Lymphocytic_T_CD4-Tfh|Lung / Manually curated celltypes from each tissue

NCOA2 ATG9B ADGRD1

3.81e-04134473da3cb572d0c19932619e51e272c0555e91b482ac
ToppCellPND10-Immune-Immune_Myeloid-DC-cDC2-cDC2_mature|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PLA2G7 NLRP1 IL6R

5.09e-0414847331a7c2b20970070b14d2b955020320a6f99db547
ToppCellPND03-Immune-Immune_Myeloid-DC-cDC2-cDC2_mature|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

B3GNT7 GSDMD IL6R

5.09e-041484733f48f5ba0a0928ddf6da7a1be1976933921f42ad
ToppCell356C-Lymphocytic-NK_cells-NK_cell_C|NK_cells / Donor, Lineage, Cell class and subclass (all cells)

LTBP2 ADGRD1

5.52e-04334725ce59ecc7f8432b14dc6cb9af56e1bf080e7d61f
ToppCellE18.5-samps-Endothelial-Mature_fetal_endothelial-capillary_endothelial_Hpgd-CA4_high|E18.5-samps / Age Group, Lineage, Cell class and subclass

MUC16 ROBO4 ADGRD1

5.71e-04154473212c340a096a3a9669d1aebd61c045cf1402a868
ToppCell356C-Lymphocytic-CD8+_Cytotoxic_T-cell|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

MUC16 MUC6 DTNA

6.04e-04157473f2bc60ec0305b056d79f1b7fd6b5e3730d606916
ToppCellPND07-Immune-Immune_Myeloid-Monocytic-Macrophage-iMON-iMON_prolif|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CD44 NLRP1 IL6R

6.04e-04157473552fd5d09bbe81f58404ec38166feb30fc84def5
ToppCellAdult-Mesenchymal-chondrocyte|Adult / Lineage, Cell type, age group and donor

POM121L2 LTBP2 LINC01356

6.27e-041594733f7305ee76447064b5c846c4f576360a2f7e0b7c
ToppCellSevere-B_naive-11|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)

ANKK1 SF1 MTSS1

6.50e-04161473ad3b58e3a8b59a609c8d2d2690d15218d18eabbd
ToppCellMyeloid|World / shred on cell class and cell subclass (v4)

CD44 PLA2G7 IL6R

6.50e-04161473aee407d3739dba2d5216dcdb1579e7e4f483123d
ToppCellfacs-Lung-nan-3m-Myeloid-Nonclassical_Monocyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CD44 PLA2G7 IL6R

6.61e-041624733fd6aaf0fbaffc7ab38aa25e46c37ef511e1e704
ToppCellfacs-Lung-nan-3m-Myeloid-non-classical_monocyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CD44 PLA2G7 IL6R

6.61e-041624738134f73eb76693f4f1845f643042fdc1e81c274c
ToppCelldroplet-Marrow-nan-18m-Lymphocytic-immature_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC18A1 UBAC1 ICAM4

6.61e-0416247308ee7ae56e4927874515c47adc86dd845bf29a26
ToppCellPND10-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

BCR SLC18A1 ITIH2

6.85e-041644734cfc9f92e49f86d3639e018b35b6a60dc62f494a
ToppCellPND10-Endothelial-Endothelial_lymphatic-Lymphatic_EC|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

BCR SLC18A1 ITIH2

6.85e-041644737a8e5ef52a8fd2877d59ef0696af8a7af90bbed6
ToppCellPND10-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC-LEC_mature|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

BCR SLC18A1 ITIH2

6.85e-041644735e5bd81414ea2d64f73cdef19a0a78c17bec8c18
ToppCellPND10-Endothelial-Endothelial_lymphatic|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

BCR SLC18A1 ITIH2

6.85e-04164473f13b8d9b7f42193f333d9a77571a1dde6bbb48d8
ToppCellCOVID-19-lung-Mesothelial|COVID-19 / Disease (COVID-19 only), tissue and cell type

MUC16 DLEC1 ADGRD1

6.85e-0416447383303e2ba52008391b8dc3fae8225ab5bcb20063
ToppCellPND28-Immune-Immune_Myeloid-Monocytic-Macrophage-iMON-iMON_mature|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CD44 PLA2G7 IL6R

6.98e-041654731d844d19ff9b49dd0f61f0b24799e172076771ef
ToppCellPND14-Immune-Immune_Myeloid|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CD44 PLA2G7 IL6R

6.98e-04165473e37d00084f58fbd25f66ee65be510c030167084e
ToppCellfacs-Lung-nan-3m-Myeloid|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CD44 PLA2G7 IL6R

6.98e-04165473720649f330382ea2a68c64a5344160a048afb8f1
ToppCellPND28-Immune-Immune_Myeloid-Monocytic-Macrophage|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CD44 PLA2G7 IL6R

6.98e-041654739a6abd0e6b11860231ce5e845c87b8d66f3ef697
ToppCellfacs-Liver-Liver_non-hepato/SCs-18m-Myeloid-neutrophil|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CD44 PLA2G7 POM121L2

6.98e-041654734fe7c3c9370a556cf4e308a2e723b4b907a6cc25
ToppCellPND28-Immune-Immune_Myeloid-Monocytic-Macrophage-iMON|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CD44 PLA2G7 IL6R

6.98e-04165473433771abefc5bcb89bdae64af45cce7407bffe5d
ToppCellE18.5-Immune-Immune_Myeloid-Monocytic-Macrophage|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CD44 PLA2G7 IL6R

7.10e-0416647373b472ea846968a08b2ac09269fca5b333ecdf2d
ToppCellfacs-Lung-ENDOMUCIN-18m-Myeloid-Classical_Monocyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PLA2G7 NLRP1 IL6R

7.10e-0416647382fa07632f7e586698fbf37381715b40f9f6ae3a
ToppCellPND01-03-samps-Myeloid|PND01-03-samps / Age Group, Lineage, Cell class and subclass

CD44 PLA2G7 B3GNT7

7.10e-0416647399dc8a186ec12d3563e81fa4618a814740332c73
ToppCelldroplet-Pancreas-Exocrine-21m-Epithelial-pancreatic_acinar_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

EPN3 ATG9B PKD1L2

7.10e-04166473b7f303203068b205f382788815df487a0ea148ed
ToppCellPND28-Immune-Immune_Myeloid|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CD44 PLA2G7 IL6R

7.10e-04166473caa992944bc7488a6868dbd1902bc3ead6945eb1
ToppCellfacs-Lung-ENDOMUCIN-18m-Myeloid-classical_monocyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PLA2G7 NLRP1 IL6R

7.10e-041664730d03926452414f232c77fd15d5f48d148f9fca3b
ToppCellPND14-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

MUC16 CCDC80 ADGRD1

7.22e-04167473c042d6cdddd0e1ddef1e3ac6f4fe23151127b0f2
ToppCelldroplet-Liver-LIVER_HEPATOCYTES-30m-Myeloid-Kupffer_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

EPN3 LTBP2 DTNA

7.22e-04167473cf6206c506715cd846799c62cf7c06e3fa99f7af
ToppCellPND14-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial-Mesothelial_mature|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

MUC16 CCDC80 ADGRD1

7.22e-04167473351f8de1fbdf742ac74f9099b254d515ab539bb2
ToppCell5'-Adult-SmallIntestine-Epithelial-Tuft-related-Tuft|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

KMT2C SLC18A1 MTSS1

7.35e-041684738072d0496b7b730c4601009eaa69ec5366d26d73
ToppCelldroplet-Marrow-BM-1m-Myeloid-basophil|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PLA2G7 PKD1L2 ADGRD1

7.35e-041684732e88d9cb7c80a4656fab290db8b45a5a0599d769
ToppCellPND03-Immune-Immune_Myeloid|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CD44 PLA2G7 IL6R

7.35e-04168473f7b911ed2d9d38bab6609da3c37e157ccf1c867b
ToppCellfacs-Liver-Non-hepatocytes-24m-Myeloid-nan|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CD44 PLA2G7 IL6R

7.48e-041694732d3618f78484bd3508b7bdae3a0d0183cdae5057
ToppCelldroplet-Heart-4Chambers-18m-Hematologic|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CD44 NLRP1 PSD4

7.48e-04169473ea43002e74076aa03bf688c0a76c07117787d4b5
ToppCelldroplet-Thymus-nan-18m-Myeloid-Macrophage|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

EPN3 DTNA ITIH2

7.48e-041694734ac21e8199de4b6917eacadc56fffc6d886ee643
ToppCelldroplet-Liver-LIVER_HEPATOCYTES-30m-Myeloid-Kupffer_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

EPN3 LTBP2 DTNA

7.48e-0416947330141f76e9bfc2b4586429857c72dbc85ba65cc9
ToppCellfacs-Lung-24m-Hematologic-myeloid-classical_monocyte-classical_monocyte_l2|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

CD44 PLA2G7 IL6R

7.48e-04169473907e4c7d0df6dd46664d69834251aebca8e1dd1e
ToppCellfacs-Liver-Non-hepatocytes-24m-Myeloid|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CD44 PLA2G7 IL6R

7.61e-04170473f08aa6168ff0c20b2083dbf588dd3294e3d9580e
ToppCellMonocytes-Cryobiopsy_01|World / lung cells shred on cell class, cell subclass, sample id

NLRP1 SLC18A1 MTSS1

7.61e-041704734e93b66b3033e6e4d5f6d2f41974623a53108f5e
ToppCellSevere-B_naive-11|Severe / disease group and sub_cluster of B and Plasma cells(res = 0.5)

ANKK1 SF1 MTSS1

7.74e-041714737c2699f19ca38414447a286f7658f507882d57c2
ToppCell10x_3'_v2v3-Non-neoplastic-Vascular-Mural_cell-Pericyte-B|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

EPAS1 ITIH2 ADGRD1

7.74e-04171473a4a2c5dc995589fbe3d4ca6ee1df888807e4ae34
ToppCellPND07-Immune-Immune_Myeloid|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CD44 PLA2G7 IL6R

7.74e-04171473f68cbfa2eb1f39401a31dbd9b630023249406098
ToppCellprimary_visual_cortex-Neuronal-glutamatergic_neuron-L6_IT-L6_IT_VISp_Penk_Col27a1|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

CCDC80 KCNG4 ADGRD1

7.74e-04171473d07e2c5f7d7f12c68860d4161d76372de174f1d8
ToppCelldroplet-Heart-4Chambers-18m-Hematologic-leukocyte|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CD44 NLRP1 PSD4

7.74e-041714734935a95d11ac997d183fab32cbaad837bf0a512b
ToppCelldroplet-Liver-Npc-18m|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CD44 PLA2G7 PSD4

7.74e-04171473e9c42ce444d42cbb4f97e81393756531bfe61637
ToppCelldroplet-Liver-Hepatocytes-21m-Myeloid-Kupffer_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CD44 PLA2G7 IL6R

7.87e-04172473574ebdf36e45222bcd907cd2c2ee7ff50ed4573a
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid-Monocytic-Monocyte-derived_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

PLA2G7 MUC16 CACNA2D4

7.87e-0417247372fbfa890995e47048b47199c170cc7dcd7661f8
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid-Monocytic|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

PLA2G7 MUC16 CACNA2D4

7.87e-041724732ca6f0d1181aabe0d0e3e8f2e193f08dbda42dea
ToppCell390C-Endothelial_cells-Endothelial-C_(Capillary_Aerocyte_)|390C / Donor, Lineage, Cell class and subclass (all cells)

ROBO4 DTNA EPAS1

7.87e-041724736f302ed795767a9636081dc64373f8f039ea16d2
ToppCellfacs-BAT-Fat-18m-Myeloid|BAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CD44 PLA2G7 IL6R

7.87e-041724738e91831804a120037c71cd4e74af686f3c32d31c
ToppCellPND14-Immune-Immune_Myeloid-Monocytic-Macrophage-iMON|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CD44 PLA2G7 IL6R

7.87e-04172473e72966ced5f2ee9e24ce9fd820d99a69a482a607
ToppCellfacs-Lung-ENDOMUCIN-18m-Myeloid|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CD44 PLA2G7 NLRP1

7.87e-041724730457ccc18697aaec44b7c30ae157aae8f48d8785
ToppCell390C-Endothelial_cells-Endothelial-C_(Capillary_Aerocyte_)-|390C / Donor, Lineage, Cell class and subclass (all cells)

ROBO4 DTNA EPAS1

7.87e-04172473fd8097299fc05390b30afaa9e6c80b1f607c27aa
ToppCellkidney_cells-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Glomerular_Capillary_Endothelial_Cell_prolif|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ROBO4 EPAS1 MTSS1

7.87e-0417247394093d356b0252b440deda4e1b0ac332b31513f6
ToppCellfacs-BAT-Fat-18m-Myeloid-myeloid_cell|BAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CD44 PLA2G7 IL6R

7.87e-04172473ea4da9aab7a2ff854df21da01d11c9ed99e41fb4
ToppCellfacs-Lung-24m-Hematologic-myeloid-classical_monocyte|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

CD44 PLA2G7 IL6R

7.87e-04172473f557ec1b4d08b42559da02dd1f2387283c6380a2
DrugChlorambucil [305-03-3]; Down 200; 13.2uM; MCF7; HT_HG-U133A

CD44 LTBP2 GNAS ITIH2 IL6R PVR ICAM4

1.22e-071954674345_DN
Drug3-aminobenzamide; Up 200; 10000uM; MCF7; HG-U133A

CD44 DLEC1 SNAPC4 BCR FASTK EPAS1 PVR

1.27e-07196467590_UP
DrugKetanserin tartrate hydrate [83846-83-7]; Up 200; 7uM; MCF7; HT_HG-U133A

POM121L2 LTBP2 GSDMD EPAS1 BAG4 PRSS21 PSD4

1.31e-071974673209_UP
DrugSulconazole nitrate [61318-91-0]; Up 200; 8.6uM; PC3; HT_HG-U133A

ROBO4 MUC6 DTNA PVR MTSS1 PRSS21 PSD4

1.36e-071984676652_UP
DrugN6,2'-O-Dibutyryladenosine 3',5'-cyclic monophosphate sodium salt; Up 200; 20uM; MCF7; HG-U133A

CD44 DLEC1 SNAPC4 BCR FASTK UBAC1 PVR

1.45e-07200467591_UP
Drug(-) -Levobunolol hydrochloride [27912-14-7]; Down 200; 12.2uM; HL60; HT_HG-U133A

POM121L2 NLRP1 LTBP2 GNAS BCR MTSS1

2.50e-061944663015_DN
DrugPhenazopyridine hydrochloride [136-40-3]; Down 200; 16uM; MCF7; HT_HG-U133A

MAML1 KAT2A GNAS ITIH2 PVR PSD4

2.73e-061974666100_DN
DrugParomomycin sulfate [1263-89-4]; Down 200; 5.6uM; HL60; HT_HG-U133A

NLRP1 LTBP2 GNAS MUC6 PVR BAG4

2.89e-061994663017_DN
Drugguanidinoacetate

CD44 ROBO4 GNAS MTSS1

3.68e-0652464CID000000763
DrugTracazolate hydrochloride [41094-88-6]; Down 200; 11.8uM; HL60; HT_HG-U133A

KAT2A FASTK IL6R MTSS1 PSD4

4.19e-051924652919_DN
DrugMetaproterenol sulfate, orciprenaline sulfate [5874-97-5]; Down 200; 7.6uM; HL60; HT_HG-U133A

POM121L2 NLRP1 DTNA PVR MTSS1

4.40e-051944652485_DN
DrugHexestrol [84-16-2]; Down 200; 14.8uM; HL60; HT_HG-U133A

BCR DTNA ICAM4 BAG4 PSD4

4.40e-051944652515_DN
DrugUngerine nitrate; Down 200; 10.2uM; MCF7; HT_HG-U133A

MAML1 NCOA2 GNAS DTNA PVR

4.40e-051944656076_DN
DrugNabumetone [42924-53-8]; Down 200; 17.6uM; HL60; HT_HG-U133A

CD44 NCOA2 BCR FASTK PSD4

4.51e-051954653108_DN
DrugKetorolac tromethamine [74103-07-4]; Down 200; 10.6uM; HL60; HT_HG-U133A

PLA2G7 POM121L2 NLRP1 BCR PSD4

4.51e-051954653110_DN
DrugAmpyrone [83-07-8]; Down 200; 19.6uM; MCF7; HT_HG-U133A

NCOA2 LTBP2 DTNA IL6R ICAM4

4.51e-051954656845_DN
Drugretinoic acid; Up 200; 1uM; MCF7; HG-U133A

DLEC1 FASTK EPAS1 PVR PSD4

4.62e-05196465384_UP
DrugAllantoin [97-59-6]; Down 200; 25.2uM; PC3; HT_HG-U133A

NCOA2 GNAS EPAS1 PVR BAG4

4.62e-051964655052_DN
Drugprobucol; Up 200; 10uM; MCF7; HG-U133A

CD44 DLEC1 SNAPC4 BCR ITIH2

4.62e-05196465592_UP
DrugMonocrotaline [315-22-0]; Up 200; 12.2uM; MCF7; HT_HG-U133A

CD44 POM121L2 IL6R PVR PSD4

4.74e-051974652749_UP
DrugFlunixin meglumine [42461-84-7]; Up 200; 8.2uM; MCF7; HT_HG-U133A

MAML1 ITIH2 PVR ICAM4 PSD4

4.74e-051974653411_UP
DrugMexiletine hydrochloride [5370-01-4]; Down 200; 18.6uM; MCF7; HT_HG-U133A

BCR DTNA PVR BAG4 PSD4

4.74e-051974652324_DN
DrugDiltiazem hydrochloride [33286-22-5]; Up 200; 8.8uM; MCF7; HT_HG-U133A

NCOA2 POM121L2 IL6R PVR ICAM4

4.74e-051974651532_UP
DrugFurazolidone [67-45-8]; Down 200; 17.8uM; HL60; HT_HG-U133A

MAML1 PLA2G7 POM121L2 LTBP2 GNAS

4.74e-051974653019_DN
DrugVinpocetine [42971-09-5]; Down 200; 11.4uM; MCF7; HT_HG-U133A

NCOA2 KAT2A SNAPC4 DTNA MTSS1

4.74e-051974657213_DN
DrugPiperine [94-62-2]; Up 200; 14uM; HL60; HT_HG-U133A

POM121L2 LTBP2 SNAPC4 BCR MTSS1

4.74e-051974651327_UP
Drug2-Chloropyrazine [14508-49-7]; Up 200; 35uM; PC3; HT_HG-U133A

MAML1 POM121L2 NLRP1 ITIH2 PSD4

4.74e-051974655750_UP
DrugStreptomycin sulfate [3810-74-0]; Up 200; 2.8uM; PC3; HT_HG-U133A

POM121L2 SNAPC4 BCR MUC6 EPAS1

4.85e-051984655837_UP
Druggenistein; Down 200; 10uM; HL60; HT_HG-U133A

POM121L2 SNAPC4 DTNA PVR ICAM4

4.85e-051984656194_DN
Drugpaclitaxel; Up 200; 0.1uM; MCF7; HG-U133A

CD44 ROBO4 SNAPC4 PVR PSD4

4.85e-05198465640_UP
DrugFlorfenicol [73231-34-2]; Up 200; 11.2uM; MCF7; HT_HG-U133A

LTBP2 MUC6 ITIH2 IL6R PVR

4.85e-051984656460_UP
DrugMephentermine hemisulfate [1212-72-2]; Up 200; 9.4uM; HL60; HT_HG-U133A

NCOA2 NLRP1 EPAS1 MTSS1 PRSS21

4.97e-051994652563_UP
DrugProparacaine hydrochloride [5875-06-9]; Up 200; 12uM; MCF7; HT_HG-U133A

DTNA EPAS1 ITIH2 PVR PSD4

4.97e-051994656492_UP
DrugAlbendazole [54965-21-8]; Up 200; 15uM; MCF7; HT_HG-U133A

LTBP2 MUC6 PVR PRSS21 PSD4

4.97e-051994653164_UP
DrugMesoridazine besylate [32672-69-8]; Up 200; 7.4uM; HL60; HG-U133A

NLRP1 FASTK GSDMD IL6R BAG4

4.97e-051994651725_UP
DrugLomefloxacin hydrochloride [98079-52-8]; Up 200; 10.4uM; HL60; HT_HG-U133A

SNAPC4 FASTK DTNA ITIH2 PVR

5.09e-052004652348_UP
DrugDiazoxide [364-98-7]; Up 200; 17.4uM; HL60; HG-U133A

POM121L2 GNAS SNAPC4 FASTK DTNA

5.09e-052004651368_UP
Drugaprosulate

CD44 ICAM4

1.11e-048462CID000072125
Drugfamciclovir

CCDC80 NLRP1 FASTK

1.59e-0452463CID000003324
Drugtridodecyl phosphite

ROBO4 BCR FASTK

1.68e-0453463CID000076495
DrugAC1L3JHX

TSC2 BCR MTSS1 PRSS21

2.15e-04146464CID000090206
Drug3-butene-1,2-diol

NLRP1 GNAS

2.17e-0411462CID000010338
Drugmercuric bromide

EPN3 CD44 TSC2 GNAS PKD1L2 DTNA EPAS1 IL6R MTSS1

2.58e-041076469ctd:C042720
Drug3-aminobenzamide

CD44 NLRP1 GNAS ICAM4

2.77e-04156464CID000001645
Drughexadecyl octanoate

TSC2 ICAM4 MTSS1

2.82e-0463463CID000448864
DrugTx F

IL6R ICAM4

3.58e-0414462CID006852176
DrugBDE-47

NLRP1 ICAM4

3.58e-0414462CID000095170
Drugphenylethylmalonamide

GNAS FASTK

4.12e-0415462CID000023611
Druganti-O

ROBO4 BCR FASTK

4.53e-0474463CID000017345
DrugMetaproterenol sulfate, orciprenaline sulfate [5874-97-5]; Up 200; 7.6uM; PC3; HT_HG-U133A

MAML1 DTNA EPAS1 ITIH2

4.66e-041794644248_UP
DrugAC1NE2TW

CD44 ICAM4

4.71e-0416462CID004635679
Drugfeldspar

BCR ITIH2

4.71e-0416462CID003080680
DrugICI 182,780; Down 200; 1uM; MCF7; HT_HG-U133A

KAT2A SNAPC4 PVR PSD4

4.76e-041804645202_DN
DrugSAHA; Down 200; 10uM; HL60; HT_HG-U133A

CD44 NCOA2 IL6R PSD4

4.76e-041804642680_DN
DrugNortriptyline hydrochloride [894-71-3]; Up 200; 13.4uM; MCF7; HT_HG-U133A

NCOA2 PVR BAG4 PSD4

4.96e-041824647422_UP
DrugPrimaquine diphosphate [63-45-6]; Up 200; 8.8uM; HL60; HT_HG-U133A

DTNA GSDMD EPAS1 PVR

5.06e-041834641343_UP
Drugazobenzene

DTNA ITIH2

5.33e-0417462CID000002272
Drug0297417-0002B [362658-29-5]; Up 200; 10uM; MCF7; HT_HG-U133A

CD44 POM121L2 GNAS DTNA

5.38e-041864646900_UP
Drug3-hydroxy-4-prenyl-5-methoxystilbene-2-carboxylic acid

GNAS SF1 EPAS1

5.48e-0479463ctd:C549543
DrugEstradiol-17 beta [50-28-2]; Up 200; 14.6uM; HL60; HT_HG-U133A

NCOA2 FASTK IL6R ICAM4

5.60e-041884641299_UP
DrugLY 294002; Down 200; 10uM; MCF7; HT_HG-U133A

KAT2A DTNA SF1 PVR

5.60e-041884645224_DN
DrugEthynodiol diacetate [297-76-7]; Down 200; 10.4uM; HL60; HT_HG-U133A

CD44 NLRP1 GSDMD ICAM4

5.60e-041884643102_DN
DrugTrichostatin A, from Streptomyces sp.; Up 200; 0.1uM; MCF7; HT_HG-U133A

NLRP1 EPAS1 MTSS1 PSD4

5.60e-041884643177_UP
Drugretinoic acid; Down 200; 1uM; HL60; HT_HG-U133A

CD44 PLA2G7 SNAPC4 PVR

5.72e-041894646170_DN
DrugColchicine [64-86-8]; Up 200; 10uM; MCF7; HT_HG-U133A

MAML1 SNAPC4 DTNA ITIH2

5.72e-041894645675_UP
DrugLorglumide sodium salt [97964-56-2]; Down 200; 8.4uM; MCF7; HT_HG-U133A

CD44 NCOA2 GNAS PSD4

5.72e-041894645254_DN
Drugwortmannin; Down 200; 1uM; MCF7; HT_HG-U133A_EA

KAT2A PVR MTSS1 PSD4

5.72e-04189464869_DN
DrugRetinoic acid [302-79-4]; Up 200; 13.4uM; MCF7; HT_HG-U133A

MUC6 EPAS1 PVR PSD4

5.72e-041894643165_UP
Drug2-propylpentanoic acid; Down 200; 200uM; HL60; HT_HG-U133A

CD44 DTNA IL6R PSD4

5.95e-041914646173_DN
DrugHarmol hydrochloride monohydrate [40580-83-4]; Down 200; 15.8uM; MCF7; HT_HG-U133A

CD44 IL6R BAG4 PSD4

5.95e-041914646022_DN
DrugPiribedil hydrochloride [78213-63-5]; Down 200; 12uM; MCF7; HT_HG-U133A

CD44 GNAS DTNA PVR

5.95e-041914645434_DN
DrugGR 55562

NLRP1 SLC18A1

5.99e-0418462CID000128017
Drugracer

CD44 ICAM4

5.99e-0418462CID000091677
Drug15(S)-15-methyl Prostaglandin E2; Up 200; 10uM; MCF7; HT_HG-U133A

NCOA2 MUC16 GNAS PSD4

6.06e-041924647489_UP
DrugLY 294002; Down 200; 10uM; HL60; HT_HG-U133A

NCOA2 PLA2G7 GNAS DTNA

6.06e-041924642699_DN
DrugDobutamine hydrochloride [49745-95-1]; Up 200; 11.8uM; HL60; HG-U133A

NLRP1 SNAPC4 FASTK PVR

6.06e-041924641589_UP
DrugNitrendipine [39562-70-4]; Up 200; 11uM; HL60; HT_HG-U133A

POM121L2 MUC6 PVR MTSS1

6.06e-041924643087_UP
Drugclozapine; Down 200; 10uM; HL60; HT_HG-U133A

BCR EPAS1 PVR BAG4

6.06e-041924646188_DN
DrugSyrosingopine [84-36-6]; Up 200; 6uM; MCF7; HT_HG-U133A

CD44 DTNA BAG4 MTSS1

6.06e-041924646213_UP
Drug2-propylpentanoic acid; Up 200; 1000uM; MCF7; HG-U133A

CD44 NLRP1 FASTK MTSS1

6.06e-0419246423_UP
Drug2-Aminobenzenesulfonamide [3306-62-5]; Down 200; 23.2uM; MCF7; HT_HG-U133A

GNAS DTNA IL6R PVR

6.06e-041924643400_DN
DrugNimodipine [66085-59-4]; Down 200; 9.6uM; HL60; HT_HG-U133A

NCOA2 LTBP2 BCR DTNA

6.18e-041934643103_DN
DrugDizocilpine maleate [77086-22-7]; Up 200; 11.8uM; MCF7; HT_HG-U133A

CD44 FASTK SF1 IL6R

6.18e-041934646223_UP
DrugSTOCK1N-35215; Up 200; 10uM; MCF7; HT_HG-U133A

POM121L2 NLRP1 DTNA IL6R

6.18e-041934646422_UP
DrugMeclocycline sulfosalicylate [73816-42-9]; Up 200; 5.8uM; HL60; HT_HG-U133A

FASTK DTNA PVR ICAM4

6.18e-041934641341_UP
DrugOmeprazole [73590-58-6]; Down 200; 11.6uM; MCF7; HT_HG-U133A

NCOA2 BCR DTNA BAG4

6.18e-041934644951_DN
DrugDosulepin hydrochloride [897-15-4]; Down 200; 12uM; MCF7; HT_HG-U133A

DTNA IL6R BAG4 PSD4

6.18e-041934645986_DN
Drug2-propylpentanoic acid; Down 200; 200uM; HL60; HT_HG-U133A

KAT2A SNAPC4 FASTK DTNA

6.18e-041934641155_DN
DrugRapamycin; Down 200; 0.1uM; MCF7; HT_HG-U133A

MAML1 FASTK IL6R PVR

6.18e-041934645239_DN
DrugNorcyclobenzaprine [303-50-4]; Down 200; 15.4uM; HL60; HT_HG-U133A

POM121L2 NLRP1 FASTK PSD4

6.30e-041944642469_DN
DrugCefoxitin sodium salt [33564-30-6]; Down 200; 8.8uM; HL60; HT_HG-U133A

NCOA2 PLA2G7 NLRP1 DTNA

6.30e-041944642735_DN
DrugHydrastinine hydrochloride [4884-68-8]; Down 200; 16.4uM; PC3; HT_HG-U133A

NCOA2 LTBP2 PVR BAG4

6.30e-041944645075_DN
DrugNorfloxacin [70458-96-7]; Down 200; 12.6uM; PC3; HT_HG-U133A

CD44 PLA2G7 PVR MTSS1

6.30e-041944647283_DN
DrugDantrolene sodium salt [14663-23-1]; Down 200; 11.8uM; MCF7; HT_HG-U133A

CD44 NCOA2 DTNA PSD4

6.30e-041944643867_DN
DrugOrphenadrine hydrochloride [341-69-5]; Up 200; 13uM; PC3; HT_HG-U133A

POM121L2 SNAPC4 PVR PSD4

6.30e-041944644537_UP
Drug(+,-)-Synephrine [94-07-5]; Down 200; 24uM; HL60; HT_HG-U133A

POM121L2 KAT2A ITIH2 PVR

6.30e-041944646156_DN
DrugDapsone [80-08-0]; Up 200; 16.2uM; MCF7; HT_HG-U133A

CD44 BCR DTNA PVR

6.30e-041944645498_UP
DrugPentylenetetrazole [54-95-5]; Down 200; 29uM; HL60; HG-U133A

CD44 KAT2A SNAPC4 PSD4

6.30e-041944641408_DN
DrugEthambutol dihydrochloride [1070-11-7]; Down 200; 14.4uM; PC3; HT_HG-U133A

BCR DTNA EPAS1 PVR

6.30e-041944644001_DN
DrugSertaconazole nitrate [99592-39-9]; Down 200; 8uM; HL60; HT_HG-U133A

NCOA2 POM121L2 GSDMD ITIH2

6.30e-041944646128_DN
Diseasevon Hippel-Lindau disease (is_marker_for)

SLC18A1 EPAS1

2.38e-062462DOID:14175 (is_marker_for)
Diseasepancreatic cancer (is_marker_for)

MUC16 GNAS MUC6 BAG4

1.89e-05101464DOID:1793 (is_marker_for)
DiseaseAcute Myeloid Leukemia, M1

CD44 KMT2C TSC2 PVR

4.36e-05125464C0026998
DiseaseAcute Myeloid Leukemia (AML-M2)

CD44 KMT2C TSC2 PVR

4.36e-05125464C1879321
DiseaseLiver Diseases, Parasitic

KMT2C GNAS

8.50e-059462C0023897
DiseaseHereditary Diffuse Gastric Cancer

CD44 KMT2C MUC6 IL6R MTSS1

9.16e-05293465C1708349
DiseaseStomach Neoplasms

CD44 KMT2C MUC6 IL6R MTSS1

9.77e-05297465C0038356
DiseaseMalignant neoplasm of stomach

CD44 KMT2C MUC6 IL6R MTSS1

1.02e-04300465C0024623
DiseaseLeukemia, Myelocytic, Acute

CD44 KMT2C TSC2 PVR

1.54e-04173464C0023467
Diseasepolycystic kidney disease (biomarker_via_orthology)

GNAS EPAS1

4.00e-0419462DOID:0080322 (biomarker_via_orthology)
DiseaseIntrahepatic Cholangiocarcinoma

KMT2C GNAS

6.42e-0424462C0345905
DiseaseExtrahepatic Cholangiocarcinoma

KMT2C GNAS

6.42e-0424462C3805278
DiseaseCholangiocarcinoma

KMT2C GNAS

7.55e-0426462C0206698
Diseasestimulant use measurement

NCOA2 DLEC1

8.76e-0428462EFO_0600076
Diseasesuicidal ideation

NCOA2 LTBP2

9.40e-0429462EFO_0004320
Diseasepeptic ulcer disease

GNAS MUC6

1.22e-0333462MONDO_0004247
Diseaselung non-small cell carcinoma (is_implicated_in)

NCOA2 KMT2C EPAS1

1.34e-03139463DOID:3908 (is_implicated_in)

Protein segments in the cluster

PeptideGeneStartEntry
PGNLYMTESTSPWPS

BAG4

266

O95429
MTESTSPWPSSGSPQ

BAG4

271

O95429
TPLSSMGGRSNTQWP

EPAS1

626

Q99814
DNSMTWEASFSPPGP

ADGRD1

151

Q6QNK2
LPANPSQPITMTDSW

BCR

1221

P11274
GMRPSLQPVSDQWPS

ANKK1

241

Q8NFD2
EATSNDPWGPPSSLM

EPN3

26

Q9H201
QSAPWQERSTMSLPP

GSDMD

411

P57764
SNPGTPINMPWLGST

DMXL1

2716

Q9Y485
MTTTAFPTTQRPWTP

CCDC80

376

Q76M96
NSPIWESGFTMPPSE

KAT2A

371

Q92830
PQDRPSSPGMDSTPW

FAM47C

6

Q5HY64
CAGPGESWSPSPNSM

FASTK

21

Q14296
QQATPAPAPGQMSTW

MAML1

416

Q92585
APAPGQMSTWQQTGP

MAML1

421

Q92585
PVFPTMDTWPTRSAQ

MUC16

896

Q8WXI7
SRTPGDVSWMTTPPV

MUC16

5611

Q8WXI7
SRGPGDMSWQSSPSL

MUC16

7076

Q8WXI7
SRSPGDMLWPSQSSV

MUC16

8246

Q8WXI7
PTTGSRPTQVWPMTG

MUC6

1211

Q6W4X9
PMASDPNNSWTSSAP

KMT2C

1606

Q8NEZ4
TPSWANPSPTPVISM

ITIH2

666

P19823
SPWSQLLSSPMETPS

KCNG4

21

Q8TDN1
PSSMWSGQASVNPPL

MTSS1

661

O43312
GSPSQPTSTAVLMPW

NLRP1

106

Q9C000
QSAPPSSPLSPNWMS

FAM205A

486

Q6ZU69
GSMTTPANWNSPLRP

PLA2G7

126

Q13093
WDRGSPNLTPSPQPM

PKD1L2

1631

Q7Z442
MGTPWTESRSPPAEN

IL6R

311

P08887
PMQGRTTPSPEDSSW

CD44

436

P16070
ANPSSSSRWIPLQPM

CACNA2D4

26

Q7Z3S7
AQPAMTPASASPSWG

ATG9B

101

Q674R7
AWVTGNATTPPMPEQ

LTBP2

806

Q14767
TWPPRPVTSMNDTLF

DTNA

336

Q9Y4J8
PTPMASQGPQAWDVT

B3GNT7

71

Q8NFL0
TNECQGTMWAPTSPP

DLEC1

16

Q9Y238
PSGTSVPFWVRMSPE

ICAM4

41

Q14773
NPEPTGYNWSTTMGP

PVR

271

P15151
SPSMPSLNQTWPELN

REPS1

401

Q96D71
PPSNFTGSSPWMEIS

GNAS

291

Q5JWF2
NSSWLPGSPMPQAQS

PSD4

551

Q8NDX1
PSLPSTTEGQMWASP

PROSER3

76

Q2NL68
TWPPSTSQADRSPMP

POM121L2

481

Q96KW2
MSCQASGQPPPTIRW

ROBO4

51

Q8WZ75
MPPWPPDSQISSQRS

ROBO4

976

Q8WZ75
GNSASRPTMPSGEWA

NCOA2

941

Q15596
RPTMPSGEWAPQSSA

NCOA2

946

Q15596
MQPSWTPAPVQRTAC

nan

1

Q9BRP9
GMNWSCRTPEPNPVT

RIPK3

431

Q9Y572
LVSGPDWNPNTSQPM

LINC01356

31

Q8N9X3
DWNPNTSQPMPGSPA

LINC01356

36

Q8N9X3
RAPALSSSWQPPANM

SNAPC4

1126

Q5SXM2
SSSWQPPANMNREPE

SNAPC4

1131

Q5SXM2
AQSGMSQPDPSWPLL

PRSS21

286

Q9Y6M0
PLNSTQWMNDPETGP

UBAC1

376

Q9BSL1
PSLMSTTQSRPPWMN

SF1

356

Q15637
TTQSRPPWMNSGPSE

SF1

361

Q15637
RPTGNTSWLMSLENP

TSC2

1201

P49815
MSPTTGPQPNPRAWE

nan

1

Q6ZRX8
AWMNDTASTIPPPAT

SLC18A1

101

P54219