Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctioncalcium ion binding

DCHS2 SPOCK1 CAPS PCDHB6 PCDHAC2 CDH23 PCDH17 ITPR3 MYOF CDH24 CELSR1 CDH20 VCAN PCDH19 DSG4 FER1L5 CDH5 HSPA5 RAB11FIP3

8.91e-0774913719GO:0005509
GeneOntologyMolecularFunctionprotein serine kinase activity

HIPK4 TRPM7 RPS6KA2 STK31 STK3 CLK1 CLK2 CDK13 NEK8 DCLK3 MAPK7

4.23e-0536313711GO:0106310
GeneOntologyMolecularFunctionprotein kinase activity

HIPK4 TRPM7 RPS6KA2 STK31 STK3 CLK1 CLK2 CDK13 NEK8 DCLK3 ROS1 MAPK7 EPHA1 EPHB1

6.68e-0560013714GO:0004672
GeneOntologyMolecularFunctionphosphotransferase activity, alcohol group as acceptor

HIPK4 TRPM7 RPS6KA2 STK31 STK3 CLK1 CLK2 CDK13 NEK8 DCLK3 ROS1 MAPK7 ADPGK EPHA1 EPHB1

1.09e-0470913715GO:0016773
GeneOntologyMolecularFunctiontelomeric repeat-containing RNA binding

HNRNPA1L2 HNRNPA1

1.40e-0431372GO:0061752
GeneOntologyMolecularFunctionNACHT domain binding

TRIM16 TRIM16L

1.40e-0431372GO:0032089
GeneOntologyMolecularFunctionkinase activity

HIPK4 TRPM7 RPS6KA2 STK31 STK3 CLK1 CLK2 CDK13 NEK8 DCLK3 ROS1 MAPK7 ADPGK EPHA1 EPHB1

2.45e-0476413715GO:0016301
GeneOntologyMolecularFunctionprotein serine/threonine kinase activity

HIPK4 TRPM7 RPS6KA2 STK31 STK3 CLK1 CLK2 CDK13 NEK8 DCLK3 MAPK7

2.59e-0444613711GO:0004674
GeneOntologyMolecularFunctionRNA strand annealing activity

HNRNPA1L2 HNRNPA1

4.61e-0451372GO:0033592
GeneOntologyMolecularFunctionprotein tyrosine kinase activity

HIPK4 CLK1 CLK2 ROS1 EPHA1 EPHB1

4.98e-041451376GO:0004713
GeneOntologyMolecularFunctiontransferase activity, transferring phosphorus-containing groups

HIPK4 TRPM7 RPS6KA2 PIGG STK31 STK3 CLK1 CLK2 CDK13 NEK8 DCLK3 ROS1 MAPK7 ADPGK EPHA1 EPHB1

7.12e-0493813716GO:0016772
GeneOntologyBiologicalProcesshomophilic cell adhesion via plasma membrane adhesion molecules

DCHS2 PCDHB6 PCDHAC2 CDH23 PCDH17 CNTN6 CDH24 CELSR1 CDH20 PCDH19 DSG4 CDH5

3.48e-0918713412GO:0007156
GeneOntologyBiologicalProcesscell-cell adhesion via plasma-membrane adhesion molecules

DCHS2 PCDHB6 PCDHAC2 CDH23 PCDH17 CNTN6 CDH24 CELSR1 CDH20 PCDH19 DSG4 MAPK7 CDH5

1.35e-0731313413GO:0098742
GeneOntologyBiologicalProcessmulti-pass transmembrane protein insertion into ER membrane

NOMO1 NOMO2 NOMO3

2.19e-0591343GO:0160063
GeneOntologyBiologicalProcesscalcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules

PCDHB6 CDH23 CDH24 CDH20 CDH5

2.40e-05531345GO:0016339
GeneOntologyCellularComponentmulti-pass translocon complex

NOMO1 NOMO2 NOMO3

2.35e-0591393GO:0160064
GeneOntologyCellularComponentcatenin complex

CDH23 CDH24 CDH20 CDH5

5.83e-05321394GO:0016342
GeneOntologyCellularComponentER membrane insertion complex

NOMO1 NOMO2 NOMO3

9.93e-05141393GO:0072379
DomainCadherin_CS

DCHS2 PCDHB6 PCDHAC2 CDH23 PCDH17 CDH24 CELSR1 CDH20 PCDH19 DSG4 CDH5

5.36e-1010913911IPR020894
DomainCADHERIN_1

DCHS2 PCDHB6 PCDHAC2 CDH23 PCDH17 CDH24 CELSR1 CDH20 PCDH19 DSG4 CDH5

7.92e-1011313911PS00232
DomainCadherin

DCHS2 PCDHB6 PCDHAC2 CDH23 PCDH17 CDH24 CELSR1 CDH20 PCDH19 DSG4 CDH5

7.92e-1011313911PF00028
DomainCADHERIN_2

DCHS2 PCDHB6 PCDHAC2 CDH23 PCDH17 CDH24 CELSR1 CDH20 PCDH19 DSG4 CDH5

8.71e-1011413911PS50268
Domain-

DCHS2 PCDHB6 PCDHAC2 CDH23 PCDH17 CDH24 CELSR1 CDH20 PCDH19 DSG4 CDH5

8.71e-10114139112.60.40.60
DomainCA

DCHS2 PCDHB6 PCDHAC2 CDH23 PCDH17 CDH24 CELSR1 CDH20 PCDH19 DSG4 CDH5

9.57e-1011513911SM00112
DomainCadherin-like

DCHS2 PCDHB6 PCDHAC2 CDH23 PCDH17 CDH24 CELSR1 CDH20 PCDH19 DSG4 CDH5

1.05e-0911613911IPR015919
DomainCadherin

DCHS2 PCDHB6 PCDHAC2 CDH23 PCDH17 CDH24 CELSR1 CDH20 PCDH19 DSG4 CDH5

1.26e-0911813911IPR002126
DomainDUF2012

NOMO1 NOMO2 NOMO3

1.60e-0641393PF09430
DomainDUF2012

NOMO1 NOMO2 NOMO3

1.60e-0641393IPR019008
DomainHSP70_2

HSPA12B HSPA12A HSPA5 HSPA9

6.49e-06171394PS00329
DomainHSP70_1

HSPA12B HSPA12A HSPA5 HSPA9

6.49e-06171394PS00297
DomainHSP70_3

HSPA12B HSPA12A HSPA5 HSPA9

6.49e-06171394PS01036
DomainHsp_70_fam

HSPA12B HSPA12A HSPA5 HSPA9

8.29e-06181394IPR013126
DomainCarb-bd-like_fold

NOMO1 NOMO2 NOMO3

2.20e-0581393IPR013784
DomainProtein_kinase_ATP_BS

HIPK4 RPS6KA2 STK3 CLK1 CLK2 CDK13 NEK8 DCLK3 ROS1 MAPK7 EPHA1 EPHB1

2.70e-0537913912IPR017441
DomainCadherin_C

CDH24 CDH20 DSG4 CDH5

3.29e-05251394PF01049
DomainCadherin_cytoplasmic-dom

CDH24 CDH20 DSG4 CDH5

3.29e-05251394IPR000233
DomainPROTEIN_KINASE_ATP

HIPK4 RPS6KA2 STK31 STK3 CLK1 CLK2 CDK13 NEK8 DCLK3 ROS1 MAPK7 EPHA1 EPHB1

3.94e-0545913913PS00107
DomainKinase-like_dom

HIPK4 TRPM7 RPS6KA2 STK31 STK3 CLK1 CLK2 CDK13 NEK8 DCLK3 ROS1 MAPK7 EPHA1 EPHB1

5.36e-0554213914IPR011009
DomainCatenin_binding_dom

CDH24 CDH20 DSG4 CDH5

6.04e-05291394IPR027397
Domain-

CDH24 CDH20 DSG4 CDH5

6.04e-052913944.10.900.10
DomainFN3

FLNC COL7A1 FSD1 CNTN6 PTPRK ROS1 EPHA1 EPHB1

7.43e-051851398SM00060
DomainProt_kinase_dom

HIPK4 RPS6KA2 STK31 STK3 CLK1 CLK2 CDK13 NEK8 DCLK3 ROS1 MAPK7 EPHA1 EPHB1

7.51e-0548913913IPR000719
DomainPROTEIN_KINASE_DOM

HIPK4 RPS6KA2 STK31 STK3 CLK1 CLK2 CDK13 NEK8 DCLK3 ROS1 MAPK7 EPHA1 EPHB1

8.15e-0549313913PS50011
DomainCarboxyPept_regulatory_dom

NOMO1 NOMO2 NOMO3

1.09e-04131393IPR014766
Domain-

NOMO1 NOMO2 NOMO3

1.09e-041313932.60.40.1120
Domain-

FLNB FLNC COL7A1 FSD1 CNTN6 NOMO1 SEMA4C PTPRK BTNL3 NOMO2 VCAN ROS1 NOMO3 EPHA1 EPHB1

1.27e-04663139152.60.40.10
DomainFerA

MYOF FER1L5

1.64e-0431392SM01200
DomainFerlin_A-domain

MYOF FER1L5

1.64e-0431392IPR012560
DomainHnRNPA1

HNRNPA1L2 HNRNPA1

1.64e-0431392IPR021662
DomainFerA

MYOF FER1L5

1.64e-0431392PF08165
DomainHnRNPA1

HNRNPA1L2 HNRNPA1

1.64e-0431392PF11627
DomainFN3_dom

FLNC COL7A1 FSD1 CNTN6 PTPRK ROS1 EPHA1 EPHB1

1.73e-042091398IPR003961
Domainfn3

COL7A1 FSD1 CNTN6 PTPRK ROS1 EPHA1 EPHB1

2.12e-041621397PF00041
DomainIg-like_fold

FLNB FLNC COL7A1 FSD1 CNTN6 NOMO1 SEMA4C PTPRK BTNL3 NOMO2 VCAN ROS1 NOMO3 EPHA1 EPHB1

2.51e-0470613915IPR013783
DomainCarboxyPept-like_regulatory

NOMO1 NOMO2 NOMO3

2.54e-04171393IPR008969
Domain-

ACLY PAICS PC

3.03e-041813933.30.470.20
DomainDysFC

MYOF FER1L5

3.27e-0441392SM00694
DomainDysFN

MYOF FER1L5

3.27e-0441392SM00693
DomainPeroxin/Ferlin

MYOF FER1L5

3.27e-0441392IPR006614
DomainSer/Thr_kinase_AS

HIPK4 RPS6KA2 STK31 STK3 CLK1 CLK2 CDK13 NEK8 DCLK3 MAPK7

3.45e-0435713910IPR008271
DomainS_TKc

HIPK4 RPS6KA2 STK31 STK3 CLK1 CLK2 CDK13 NEK8 DCLK3 MAPK7

3.61e-0435913910SM00220
DomainPROTEIN_KINASE_ST

HIPK4 RPS6KA2 STK31 STK3 CLK1 CLK2 CDK13 NEK8 DCLK3 MAPK7

3.85e-0436213910PS00108
DomainFerI

MYOF FER1L5

5.42e-0451392SM01202
DomainFerB

MYOF FER1L5

5.42e-0451392SM01201
DomainFerlin_B-domain

MYOF FER1L5

5.42e-0451392IPR012561
DomainFerlin_C

MYOF FER1L5

5.42e-0451392PF16165
DomainFerlin_C

MYOF FER1L5

5.42e-0451392IPR032362
DomainFerIin_dom

MYOF FER1L5

5.42e-0451392IPR012968
DomainFerI

MYOF FER1L5

5.42e-0451392PF08151
DomainFerB

MYOF FER1L5

5.42e-0451392PF08150
DomainPkinase

HIPK4 RPS6KA2 STK31 STK3 CLK1 CLK2 CDK13 NEK8 DCLK3 MAPK7

5.74e-0438113910PF00069
DomainFN3

COL7A1 FSD1 CNTN6 PTPRK ROS1 EPHA1 EPHB1

7.32e-041991397PS50853
DomainRBD-FIP

RAB11FIP1 RAB11FIP3

8.09e-0461392PF09457
DomainFAD-bd

COQ6 MICAL3

8.09e-0461392IPR002938
DomainFAD_binding_3

COQ6 MICAL3

8.09e-0461392PF01494
DomainRab-bd_FIP-RBD

RAB11FIP1 RAB11FIP3

8.09e-0461392IPR019018
DomainFIP_RBD

RAB11FIP1 RAB11FIP3

8.09e-0461392PS51511
DomainConA-like_dom

LAMA3 FSD1 TRIM16 CELSR1 PTPRK BTNL3 TRIM16L

1.28e-032191397IPR013320
DomainCadherin_2

PCDHB6 PCDHAC2 PCDH17 PCDH19

1.40e-03651394PF08266
DomainCadherin_N

PCDHB6 PCDHAC2 PCDH17 PCDH19

1.40e-03651394IPR013164
DomainGPCR_3_mtglu_rcpt

GRM1 GRM3

1.50e-0381392IPR000162
DomainATP_grasp_subdomain_2

ACLY PAICS PC

1.56e-03311393IPR013816
DomainIG_FLMN

FLNB FLNC

2.38e-03101392SM00557
DomainFilamin

FLNB FLNC

2.89e-03111392PF00630
DomainFILAMIN_REPEAT

FLNB FLNC

2.89e-03111392PS50194
DomainFilamin/ABP280_rpt

FLNB FLNC

2.89e-03111392IPR001298
DomainFilamin/ABP280_repeat-like

FLNB FLNC

2.89e-03111392IPR017868
Domain-

HSPA5 HSPA9

3.46e-031213922.60.34.10
DomainHSP70_peptide-bd

HSPA5 HSPA9

3.46e-03121392IPR029047
DomainPRY

TRIM16 BTNL3 TRIM16L

3.75e-03421393PF13765
DomainSPRY

FSD1 TRIM16 BTNL3 TRIM16L

4.06e-03871394SM00449
DomainHTH_Tnp_Tc5

DCHS2 TIGD4

4.06e-03131392PF03221
Domain-

HSPA5 HSPA9

4.06e-031313921.20.1270.10
DomainNCD3G

GRM1 GRM3

4.06e-03131392PF07562
DomainHeat_shock_70_CS

HSPA5 HSPA9

4.06e-03131392IPR018181
DomainHSP70_C

HSPA5 HSPA9

4.06e-03131392IPR029048
DomainGPCR_3_9-Cys_dom

GRM1 GRM3

4.06e-03131392IPR011500
DomainRECEPTOR_TYR_KIN_V_2

EPHA1 EPHB1

4.72e-03141392PS00791
DomainRECEPTOR_TYR_KIN_V_1

EPHA1 EPHB1

4.72e-03141392PS00790
DomainTyr_kinase_rcpt_V_CS

EPHA1 EPHB1

4.72e-03141392IPR001426
DomainEphA2_TM

EPHA1 EPHB1

4.72e-03141392PF14575
DomainEphrin_rcpt_lig-bd_dom

EPHA1 EPHB1

4.72e-03141392IPR001090
DomainEph_TM

EPHA1 EPHB1

4.72e-03141392IPR027936
DomainEPH_lbd

EPHA1 EPHB1

4.72e-03141392SM00615
DomainEphrin_lbd

EPHA1 EPHB1

4.72e-03141392PF01404
DomainTyr_kinase_ephrin_rcpt

EPHA1 EPHB1

4.72e-03141392IPR016257
DomainEPH_LBD

EPHA1 EPHB1

4.72e-03141392PS51550
DomainGPCR_3_CS

GRM1 GRM3

4.72e-03141392IPR017979
DomainSPRY

FSD1 TRIM16 BTNL3 TRIM16L

5.34e-03941394PF00622
DomainSPRY_dom

FSD1 TRIM16 BTNL3 TRIM16L

5.34e-03941394IPR003877
DomainGalactose-bd-like

BTBD9 PTPRK EPHA1 EPHB1

5.34e-03941394IPR008979
DomainPRY

TRIM16 BTNL3 TRIM16L

5.46e-03481393SM00589
DomainPRY

TRIM16 BTNL3 TRIM16L

5.46e-03481393IPR006574
DomainB30.2/SPRY

FSD1 TRIM16 BTNL3 TRIM16L

5.54e-03951394IPR001870
DomainB302_SPRY

FSD1 TRIM16 BTNL3 TRIM16L

5.54e-03951394PS50188
DomainIBN_N

XPO5 IPO11

6.16e-03161392SM00913
DomainHSP70

HSPA5 HSPA9

6.16e-03161392PF00012
DomainSushi

CSMD2 CSMD3 VCAN

6.83e-03521393PF00084
Pubmed

Recurrent NOMO1 Gene Deletion Is a Potential Clinical Marker in Early-Onset Colorectal Cancer and Is Involved in the Regulation of Cell Migration.

NOMO1 NOMO2 NOMO3

6.38e-083140336011023
Pubmed

Silencing of nodal modulator 1 inhibits the differentiation of P19 cells into cardiomyocytes.

NOMO1 NOMO2 NOMO3

6.38e-083140325576386
Pubmed

KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.

FLNB FLNC ACLY LRRC49 NIPSNAP1 PHB2 HNRNPA1L2 GRM1 GTPBP1 GRM3 HNRNPA1 NDUFS2 HSPA12A NWD2 VCAN SMU1 MICAL3 PC METAP2 HSPA5 HSPA9 CACNA2D3

6.85e-0814311402237142655
Pubmed

Faciogenital Dysplasia 5 supports cancer stem cell traits in basal-like breast cancer by enhancing EGFR stability.

FLNB FLNC ACLY PHB2 PAICS NOMO1 HSPA5 HSPA9 NOMO3

8.87e-08191140933762435
Pubmed

Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity.

RPS6KA2 PTER PAICS NOMO1 TRIM16 STK3 MYOF NOMO2 CLK1 CLK2 CDK13 PRKAR1B MAPK7 METAP2 HSPA5 HSPA9 NOMO3

1.68e-079101401736736316
Pubmed

Establishment of a conditional Nomo1 mouse model by CRISPR/Cas9 technology.

NOMO1 NOMO2 NOMO3

2.55e-074140331833031
Pubmed

A locus for autosomal recessive pseudoxanthoma elasticum, with penetrance of vascular symptoms in carriers, maps to chromosome 16p13.1.

NOMO1 NOMO2 NOMO3

2.55e-07414039267806
Pubmed

N-Terminomics for the Identification of In Vitro Substrates and Cleavage Site Specificity of the SARS-CoV-2 Main Protease.

FLNB FLNC ACLY PAICS ITPR3 TRIM16 MICAL3 PC METAP2 HSPA9 DYNC1I2

2.59e-073601401133111431
Pubmed

The Deubiquitinating Enzyme USP48 Interacts with the Retinal Degeneration-Associated Proteins UNC119a and ARL3.

ACLY HNRNPA1L2 HNRNPA1 PAICS NDUFS2 NOMO1 SLC6A6 HSPA12A NOMO2 HSPA5 HSPA9 NOMO3 DYNC1I2

4.04e-075521401336293380
Pubmed

A Human Tyrosine Phosphatase Interactome Mapped by Proteomic Profiling.

TMED1 FLNB FLNC ACLY DHX40 HNRNPA1L2 PAICS NOMO1 ITPR3 PTPRK XPO5 AGL ASNS SMU1 TXNDC9 TTC13 HSPA5

4.32e-079741401728675297
Pubmed

Nephrocystin-conserved domains involved in targeting to epithelial cell-cell junctions, interaction with filamins, and establishing cell polarity.

FLNB FLNC NPHP4

6.35e-075140312006559
Pubmed

An important role for CDK2 in G1 to S checkpoint activation and DNA damage response in human embryonic stem cells.

FLNB FLNC COQ6 PHB2 HNRNPA1 PAICS NOMO1 MYOF ASNS HSPA5 HSPA9

6.79e-073971401121319273
Pubmed

Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.

FLNB ERCC6 ACLY BTBD10 PHB2 LAMA3 YBX3 GTPBP1 HNRNPA1 PAICS NDUFS2 ITPR3 MYOF DDX50 SMU1 METAP2 HSPA5 HSPA9 RSBN1L

7.59e-0712571401936526897
Pubmed

Blocking an N-terminal acetylation-dependent protein interaction inhibits an E3 ligase.

FLNB ACLY HDAC8 PHB2 YBX3 BTBD9 PAICS AGL TXNDC9 TACC3 HSPA5 HSPA9

8.50e-074951401228581483
Pubmed

Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.

FLNB ACLY NIPSNAP1 PHB2 YBX3 GRM1 GTPBP1 HNRNPA1 PAICS NDUFS2 NOMO1 MRM3 DDX50 XPO5 ASNS SMU1 BOD1L1 PC HSPA5 HSPA9

1.19e-0614251402030948266
Pubmed

Systematically defining selective autophagy receptor-specific cargo using autophagosome content profiling.

FLNB ACLY COQ6 NIPSNAP1 PIGG RAB11FIP1 HNRNPA1 PAICS MYOF DDX50 XPO5 NOMO2 BOD1L1 TTC13 CTSL METAP2 HSPA5 HSPA9 ADPGK

1.21e-0612971401933545068
Pubmed

LCP1 preferentially binds clasped αMβ2 integrin and attenuates leukocyte adhesion under flow.

FLNB FLNC NOMO1 MYOF NOMO2 ASNS HSPA9 NOMO3 DYNC1I2 IPO11

1.45e-063441401030333137
Pubmed

ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.

TMED1 COL7A1 SPOCK1 ACLY B3GALNT2 PIGG PAICS DMXL1 NOMO1 SLC6A6 MYOF CELSR1 PTPRK NOMO2 TTC13 CTSL HSPA5 ADPGK

1.72e-0612011401835696571
Pubmed

Identification of proteins interacting with the mitochondrial small heat shock protein Hsp22 of Drosophila melanogaster: Implication in mitochondrial homeostasis.

NIPSNAP1 PHB2 NDUFS2 MTO1 PC HSPA5 HSPA9

2.24e-06146140729509794
Pubmed

Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.

TRPM7 NIPSNAP1 PHB2 RAB11FIP1 HSPA12B HNRNPA1 NDUFS2 DMXL1 NOMO1 ITPR3 HSPA12A TIMM21 NOMO2 ASNS SMU1 PRKAR1B TTC13 IFT80 HSPA5 HSPA9

2.27e-0614871402033957083
Pubmed

CDK7/GRP78 signaling axis contributes to tumor growth and metastasis in osteosarcoma.

FLNB FLNC NIPSNAP1 PHB2 HNRNPA1 MYOF TRAK2 PC HSPA5 HSPA9 DYNC1I2

3.33e-064681401136042349
Pubmed

Charting the landscape of tandem BRCT domain-mediated protein interactions.

FLNB TRPS1 PHB2 YBX3 HNRNPA1 PAICS NOMO1 MRM3 DDX50 CDK13 MICAL3 NOMO3 DYNC1I2

3.44e-066701401322990118
Pubmed

Nicalin and its binding partner Nomo are novel Nodal signaling antagonists.

NOMO1 NOMO2 NOMO3

3.52e-068140315257293
Pubmed

Combined treatment of human multiple myeloma cells with bortezomib and doxorubicin alters the interactome of 20S proteasomes.

PHB2 HNRNPA1 DCLK3 HSPA5 HSPA9

3.80e-0658140530009671
Pubmed

PINK1 Content in Mitochondria is Regulated by ER-Associated Degradation.

FLNB FLNC ACLY PHB2 HNRNPA1 PAICS ASNS TACC3 HSPA5 HSPA9 DYNC1I2

3.99e-064771401131300519
Pubmed

Substrate-driven assembly of a translocon for multipass membrane proteins.

NOMO1 NOMO2 NOMO3

5.27e-069140336261522
Pubmed

In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.

FLNB FLNC SPOCK1 COQ6 EML6 PHB2 YBX3 HNRNPA1L2 STK31 HNRNPA1 TRIM16 DDX50 SLC12A4 TIMM21 CDK13 BOD1L1 HSPA5 HSPA9 DYNC1I2

5.61e-0614421401935575683
Pubmed

STING-Mediated IFI16 Degradation Negatively Controls Type I Interferon Production.

ACLY YBX3 HNRNPA1L2 HNRNPA1 MRM3 SMU1 HSPA5 HSPA9 RSBN1L

5.82e-06316140931665637
Pubmed

Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV.

WWP1 COQ6 PHB2 PCDHAC2 NDUFS2 SEMA4C TRIM16 SLC6A6 MYOF SLC12A4 XPO5 PC HSPA5 HSPA9 ADPGK IPO11

6.25e-0610611401633845483
Pubmed

An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.

TMED1 GALC ZNF143 NIPSNAP1 PHB2 CDH23 RAB11FIP1 NPHP4 NDUFS2 NOMO1 STK3 XPO5 NEK8 SMU1 IFT80 HSPA5 DYNC1I2 IPO11

6.41e-0613211401827173435
Pubmed

Downregulation of the FBXO43 gene inhibits tumor growth in human breast cancer by limiting its interaction with PCNA.

FLNB FLNC ACLY HSPA5 HSPA9

6.69e-0665140534645483
Pubmed

CLEC16A interacts with retromer and TRIM27, and its loss impairs endosomal trafficking and neurodevelopment.

MKKS NDUFS2 NOMO1 STK3 NOMO2 AGL PJA1 MTO1 PC ADPGK NOMO3 IPO11

6.77e-066061401236538041
Pubmed

Hepatic lipase maturation: a partial proteome of interacting factors.

NOMO1 NOMO2 HSPA5 NOMO3

7.27e-0631140419136429
Pubmed

Human immunodeficiency virus type 1 interaction with the membrane of CD4+ cells induces the synthesis and nuclear translocation of 70K heat shock protein.

HSPA12B HSPA5 HSPA9

7.50e-061014037906708
Pubmed

gp120 neurotoxicity fails to induce heat shock defenses, while the over expression of hsp70 protects against gp120.

HSPA12B HSPA5 HSPA9

7.50e-0610140312832005
Pubmed

Transglutaminase Type 2 Regulates ER-Mitochondria Contact Sites by Interacting with GRP75.

ITPR3 HSPA5 HSPA9

7.50e-0610140330590033
Pubmed

Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.

FLNB FLNC ERCC6 ACLY DHX40 NIPSNAP1 PHB2 YBX3 HNRNPA1 PAICS DDX50 ASNS SMU1 TXNDC9 METAP2 HSPA5 HSPA9 DYNC1I2

8.88e-0613531401829467282
Pubmed

E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.

FLNB ACLY TIGD4 CSMD2 NDUFS2 PCDH17 SLC6A6 LOXHD1 CDH20 AGL ASNS BOD1L1 HSPA5

9.40e-067361401329676528
Pubmed

An ER translocon for multi-pass membrane protein biogenesis.

NOMO1 NOMO2 NOMO3

1.03e-0511140332820719
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

FLNC WWP1 RPS6KA2 PIGG NPHP4 ITPR3 MYOF CELSR1 SLC12A4 SH3TC1 ADAMTS7 CDK13 NEK8 MICAL3 PC RAB11FIP3

1.04e-0511051401635748872
Pubmed

TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.

ZNF143 DHX40 TRPS1 CSMD2 HSPA12B STK31 PTER NDUFS2 ITPR3 DSG4 FER1L5 NOMO3

1.13e-056381401231182584
Pubmed

MYC multimers shield stalled replication forks from RNA polymerase.

FLNB FLNC ACLY DHX40 PHB2 HNRNPA1 PAICS LIG1 DDX50 XPO5 BOD1L1 PC HSPA5 HSPA9 RSBN1L

1.16e-059891401536424410
Pubmed

SERBP1 Promotes Stress Granule Clearance by Regulating 26S Proteasome Activity and G3BP1 Ubiquitination and Protects Male Germ Cells from Thermostimuli Damage.

FLNB ACLY PHB2 YBX3 PAICS XPO5 CDK13 ASNS TXNDC9 TACC3 HSPA5 HSPA9 DYNC1I2 IPO11

1.33e-058781401437223481
Pubmed

Arginine methylation and ubiquitylation crosstalk controls DNA end-resection and homologous recombination repair.

FLNB FLNC ACLY YBX3 HNRNPA1 PAICS MRM3 ASNS SMU1 HSPA5 HSPA9

1.54e-055511401134728620
Pubmed

Transcriptional regulation of the human asparagine synthetase gene by carbohydrate availability.

ASNS HSPA5

1.61e-052140210085239
Pubmed

Post-translational modifications of hnRNP A1 differentially modulate retroviral IRES-mediated translation initiation.

HNRNPA1L2 HNRNPA1

1.61e-052140232960212
Pubmed

siDirect: highly effective, target-specific siRNA design software for mammalian RNA interference.

HNRNPA1L2 HNRNPA1

1.61e-052140215215364
Pubmed

Phosphorylation of hnRNP A1-Serine 199 Is Not Required for T Cell Differentiation and Function.

HNRNPA1L2 HNRNPA1

1.61e-052140238334757
Pubmed

GRP78 translocation to the cell surface and O-GlcNAcylation of VE-Cadherin contribute to ER stress-mediated endothelial permeability.

CDH5 HSPA5

1.61e-052140231346222
Pubmed

Retroviral insertions downstream of the heterogeneous nuclear ribonucleoprotein A1 gene in erythroleukemia cells: evidence that A1 is not essential for cell growth.

HNRNPA1L2 HNRNPA1

1.61e-05214021406633
Pubmed

Novel variants in LAMA3 and COL7A1 and recurrent variant in KRT5 underlying epidermolysis bullosa in five Chinese families.

COL7A1 LAMA3

1.61e-052140235314946
Pubmed

Heterogeneous nuclear ribonucleoprotein A1 regulates rhythmic synthesis of mouse Nfil3 protein via IRES-mediated translation.

HNRNPA1L2 HNRNPA1

1.61e-052140228220845
Pubmed

Glucose regulated proteins 78 and 75 bind to the receptor for hyaluronan mediated motility in interphase microtubules.

HSPA5 HSPA9

1.61e-052140216329989
Pubmed

The limits of promiscuity: isoform-specific dimerization of filamins.

FLNB FLNC

1.61e-052140212525170
Pubmed

Human proteoglycan testican-1 inhibits the lysosomal cysteine protease cathepsin L.

SPOCK1 CTSL

1.61e-052140214511383
Pubmed

Positional cloning reveals strain-dependent expression of Trim16 to alter susceptibility to bleomycin-induced pulmonary fibrosis in mice.

TRIM16 TRIM16L

1.61e-052140223341783
Pubmed

The estrogen-responsive B box protein: a novel regulator of keratinocyte differentiation.

TRIM16 TRIM16L

1.61e-052140211919186
Pubmed

Novel Pathological Role of hnRNPA1 (Heterogeneous Nuclear Ribonucleoprotein A1) in Vascular Smooth Muscle Cell Function and Neointima Hyperplasia.

HNRNPA1L2 HNRNPA1

1.61e-052140228912364
Pubmed

hnRNP A1 dysfunction in oligodendrocytes contributes to the pathogenesis of multiple sclerosis.

HNRNPA1L2 HNRNPA1

1.61e-052140236382566
Pubmed

A novel human actin-binding protein homologue that binds to platelet glycoprotein Ibalpha.

FLNB FLNC

1.61e-05214029694715
Pubmed

Differential effect of CLK SR Kinases on HIV-1 gene expression: potential novel targets for therapy.

CLK1 CLK2

1.61e-052140221682887
Pubmed

Tripartite motif 16 ameliorates nonalcoholic steatohepatitis by promoting the degradation of phospho-TAK1.

TRIM16 TRIM16L

1.61e-052140234146477
Pubmed

Heterozygous loss of keratinocyte TRIM16 expression increases melanocytic cell lesions and lymph node metastasis.

TRIM16 TRIM16L

1.61e-052140231342168
Pubmed

Two Hsp70 family members expressed in atherosclerotic lesions.

HSPA12B HSPA12A

1.61e-052140212552099
Pubmed

The E3 Ligase TRIM16 Is a Key Suppressor of Pathological Cardiac Hypertrophy.

TRIM16 TRIM16L

1.61e-052140235437018
Pubmed

Loss of hnRNP A1 in murine skeletal muscle exacerbates high-fat diet-induced onset of insulin resistance and hepatic steatosis.

HNRNPA1L2 HNRNPA1

1.61e-052140231169879
Pubmed

TRIM16 protects from OGD/R-induced oxidative stress in cultured hippocampal neurons by enhancing Nrf2/ARE antioxidant signaling via downregulation of Keap1.

TRIM16 TRIM16L

1.61e-052140232251645
Pubmed

Regulation of mouse hepatitis virus RNA synthesis by heterogeneous nuclear ribonucleoprotein A1.

HNRNPA1L2 HNRNPA1

1.61e-052140211774503
Pubmed

Role of hnRNP A1 in coronavirus RNA synthesis.

HNRNPA1L2 HNRNPA1

1.61e-052140211774505
Pubmed

HSP70s in Breast Cancer: Promoters of Tumorigenesis and Potential Targets/Tools for Therapy.

HSPA5 HSPA9

1.61e-052140234943954
Pubmed

The A1 and A1B proteins of heterogeneous nuclear ribonucleoparticles modulate 5' splice site selection in vivo.

HNRNPA1L2 HNRNPA1

1.61e-05214028041722
Pubmed

Expression of metabotropic glutamate receptor mRNAs in the human spinal cord: implications for selective vulnerability of spinal motor neurons in amyotrophic lateral sclerosis.

GRM1 GRM3

1.61e-052140211535235
Pubmed

Interplay between hnRNP A1 and a cis-acting element in the 3' UTR of CYP2A5 mRNA is central for high expression of the gene.

HNRNPA1L2 HNRNPA1

1.61e-052140212560094
Pubmed

Assembly of the U5 snRNP component PRPF8 is controlled by the HSP90/R2TP chaperones.

FLNB ACLY NIPSNAP1 PHB2 YBX3 PTER HNRNPA1 PAICS NDUFS2 MRM3 CDK13 AGL SMU1 PC METAP2 HSPA5 HSPA9 DYNC1I2

1.62e-0514151401828515276
Pubmed

Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors.

TMED1 FLNB FLNC GALC ZNF143 ACLY PHB2 NDUFS2 NOMO1 MRM3 LIG1 PTPRK NOMO2 AKR7A3 HSPA5 HSPA9 ADPGK NOMO3

2.26e-0514511401830550785
Pubmed

A high-throughput approach for measuring temporal changes in the interactome.

FLNB FLNC ACLY YBX3 HNRNPA1 PAICS TRIM16 LIG1 XPO5 AGL ASNS PRKAR1B TXNDC9 METAP2 HSPA5 HSPA9 DYNC1I2 IPO11

2.34e-0514551401822863883
Pubmed

Identification of different proteins binding to Na, K-ATPase α1 in LPS-induced ARDS cell model by proteomic analysis.

FLNB ACLY NDUFS2 MYOF HSPA5 HSPA9

2.70e-05144140635681168
Pubmed

Cell cycle-dependent phosphorylation regulates RECQL4 pathway choice and ubiquitination in DNA double-strand break repair.

ACLY DHX40 PHB2 YBX3 HNRNPA1L2 GTPBP1 HNRNPA1 PAICS NDUFS2 STK3 MRM3 ASNS SMU1 IFT80 PC HSPA5 HSPA9

2.80e-0513351401729229926
Pubmed

AMPK, a Regulator of Metabolism and Autophagy, Is Activated by Lysosomal Damage via a Novel Galectin-Directed Ubiquitin Signal Transduction System.

FLNB FLNC ACLY PHB2 HNRNPA1 PAICS ASNS PC HSPA5 HSPA9

2.84e-054841401031995728
Pubmed

Anticancer sulfonamides target splicing by inducing RBM39 degradation via recruitment to DCAF15.

ACLY DHX40 YBX3 HNRNPA1L2 HNRNPA1 PAICS DDX50 CLK1 ASNS SMU1 HSPA5 HSPA9

3.41e-057141401228302793
Pubmed

A dual-strategy expression screen for candidate connectivity labels in the developing thalamus.

CNTN6 CDH24 PCDH19 EPHA1 EPHB1

3.46e-0591140528558017
Pubmed

Proteome-wide identification of HSP70/HSC70 chaperone clients in human cells.

TMED1 FLNB FLNC GTPBP1 HNRNPA1 PAICS NDUFS2 MYOF AGL ASNS TACC3 PC METAP2 HSPA5 HSPA9 DYNC1I2 IPO11

3.76e-0513671401732687490
Pubmed

Two-Dimensional Fractionation Method for Proteome-Wide Cross-Linking Mass Spectrometry Analysis.

FLNB FLNC NIPSNAP1 PHB2 YBX3 HNRNPA1L2 HNRNPA1 NDUFS2 PRKAR1B BOD1L1 HSPA5 HSPA9 DYNC1I2

4.05e-058471401335235311
Pubmed

Proteomic identification of common SCF ubiquitin ligase FBXO6-interacting glycoproteins in three kinds of cells.

B3GALNT2 HNRNPA1 NDUFS2 NOMO1 SEMA4C NOMO2 TTC13 HSPA5 HSPA9 NOMO3 IPO11

4.07e-056131401122268729
Pubmed

Heterogeneous Nuclear Ribonucleoprotein A1 Improves the Intestinal Injury by Regulating Apoptosis Through Trefoil Factor 2 in Mice with Anti-CD3-induced Enteritis.

HNRNPA1L2 HNRNPA1

4.81e-053140225901972
Pubmed

Phosphomimetic substitution of heterogeneous nuclear ribonucleoprotein A1 at serine 199 abolishes AKT-dependent internal ribosome entry site-transacting factor (ITAF) function via effects on strand annealing and results in mammalian target of rapamycin complex 1 (mTORC1) inhibitor sensitivity.

HNRNPA1L2 HNRNPA1

4.81e-053140221454539
Pubmed

Identification of two new members of the CSMD gene family.

CSMD2 CSMD3

4.81e-053140212906867
Pubmed

PRMT5 regulates IRES-dependent translation via methylation of hnRNP A1.

HNRNPA1L2 HNRNPA1

4.81e-053140228115626
Pubmed

The CLK family kinases, CLK1 and CLK2, phosphorylate and activate the tyrosine phosphatase, PTP-1B.

CLK1 CLK2

4.81e-053140210480872
Pubmed

Filamins as integrators of cell mechanics and signalling.

FLNB FLNC

4.81e-053140211252955
Pubmed

Adipocyte-Specific Hnrnpa1 Knockout Aggravates Obesity-Induced Metabolic Dysfunction via Upregulation of CCL2.

HNRNPA1L2 HNRNPA1

4.81e-053140238320300
Pubmed

Graded heterogeneity of metabotropic signaling underlies a continuum of cell-intrinsic temporal responses in unipolar brush cells.

GRM1 GRM3

4.81e-053140234620856
Pubmed

HnRNP A1 Suppresses the Odontogenic Differentiation and the Inclusion of RUNX2 Exon 5 of Dental Mesenchymal Cells.

HNRNPA1L2 HNRNPA1

4.81e-053140237525910
Pubmed

HuR-regulated mRNAs associated with nuclear hnRNP A1-RNP complexes.

HNRNPA1L2 HNRNPA1

4.81e-053140224152440
Pubmed

Relative amounts of antagonistic splicing factors, hnRNP A1 and ASF/SF2, change during neoplastic lung growth: implications for pre-mRNA processing.

HNRNPA1L2 HNRNPA1

4.81e-053140215390079
Pubmed

A high-resolution genetic map around waltzer on mouse chromosome 10 and identification of a new allele of waltzer.

CDH23 ROS1

4.81e-05314029021139
Pubmed

HNRNPA1-mediated exosomal sorting of miR-483-5p out of renal tubular epithelial cells promotes the progression of diabetic nephropathy-induced renal interstitial fibrosis.

HNRNPA1L2 HNRNPA1

4.81e-053140233692334
Pubmed

The Splicing Factor hnRNPA1 Regulates Alternate Splicing of the MYLK Gene.

HNRNPA1L2 HNRNPA1

4.81e-053140229077485
Pubmed

Cockayne syndrome group B (Csb) and group a (Csa) deficiencies predispose to hearing loss and cochlear hair cell degeneration in mice.

ERCC6 CDH23

4.81e-053140225762674
Pubmed

Molecular cloning of the genes suppressed in RVC lymphoma cells by topoisomerase inhibitors.

HNRNPA1L2 HNRNPA1

4.81e-05314028912629
InteractionFGD5 interactions

FLNB FLNC ACLY PHB2 PAICS NOMO1 HSPA5 HSPA9 NOMO3

1.23e-052071379int:FGD5
InteractionBRAF interactions

WWP1 PHB2 NOMO1 STK3 MYOF NOMO2 HSPA5 HSPA9 NOMO3

1.49e-052121379int:BRAF
InteractionRYK interactions

TRPM7 PCDH17 CELSR1 PTPRK PCDH19 DSG4 PLD1 CDH5 NOMO3

1.49e-052121379int:RYK
InteractionEEF2KMT interactions

GALC GTPBP1 PRKAR1B HSPA5

2.72e-05261374int:EEF2KMT
InteractionARRDC2 interactions

FLNC WWP1 SMU1 BOD1L1 PJA1

3.27e-05541375int:ARRDC2
InteractionTSHR interactions

FLNB LAMA3 HNRNPA1 NOMO1 PC HSPA5

4.96e-05961376int:TSHR
InteractionSLURP1 interactions

LAMA3 PIGG NOMO1 ADAMTS7 VCAN HSPA5 EPHA1

5.83e-051441377int:SLURP1
InteractionINVS interactions

PHB2 NPHP4 NEK8 VCAN HSPA5 HSPA9

5.90e-05991376int:INVS
InteractionSAMD9L interactions

HNRNPA1L2 HNRNPA1 CLK1

6.46e-05121373int:SAMD9L
InteractionCKAP5 interactions

FLNB ACLY YBX3 SEMA4C CLK1 TACC3 METAP2 HSPA5 HSPA9 EPHA1

7.22e-0532213710int:CKAP5
GeneFamilyHeat shock 70kDa proteins

HSPA12B HSPA12A HSPA5 HSPA9

1.98e-06171004583
GeneFamilyFibronectin type III domain containing

COL7A1 FSD1 CNTN6 PTPRK ROS1 EPHA1 EPHB1

2.99e-051601007555
GeneFamilyCD molecules|Type II classical cadherins

CDH24 CDH20 CDH5

4.51e-051310031186
GeneFamilyCDC like kinases

CLK1 CLK2

1.80e-0441002480
GeneFamilyFerlin family

MYOF FER1L5

4.48e-0461002828
GeneFamilyGlutamate metabotropic receptors|Protein phosphatase 1 regulatory subunits

GRM1 GRM3

8.30e-0481002281
GeneFamilyNon-clustered protocadherins

PCDH17 PCDH19

1.93e-0312100221
GeneFamilyFibronectin type III domain containing|Sterile alpha motif domain containing|EPH receptors

EPHA1 EPHB1

2.64e-031410021095
GeneFamilyHyalectan proteoglycans|V-set domain containing|Sushi domain containing|C-type lectin domain containing

CSMD2 CSMD3 VCAN

3.87e-035710031179
GeneFamilyCadherin related

DCHS2 CDH23

3.90e-0317100224
CoexpressionMANNO_MIDBRAIN_NEUROTYPES_HGABA

COL6A6 SPOCK1 LRRC49 LAMA3 GRM1 CSMD2 GRM3 CSMD3 PCDH17 HSPA12A PTPRK VCAN PCDH19 ASNS KCNK2 DCLK3 PRKAR1B MICAL3 BOD1L1 EPHB1

1.82e-06110614020M39071
CoexpressionGSE10325_BCELL_VS_MYELOID_UP

EAF2 GTPBP1 ITPR3 LIG1 PTPRK ASNS MICAL3 PJA1

1.13e-051971408M3081
ToppCellLPS-IL1RA-Epithelial_alveolar-AT_1-Differentiating_AT2|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

LAMA3 RAB11FIP1 PTER CNTN6 MYOF CELSR1 IFT80 CACNA2D3

1.38e-0718614084e94158db52df41d71e67b02b9895a358eebee0f
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

DCHS2 GRM1 PTER PCDH17 CNTN6 NWD2 PTPRK

1.55e-061781407b169aa5eaa51730daaec69c6bc58126be1592a50
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)-Glut_D_(IT_RORB_THEMIS_LINC00507)_6-Exc_L6_THEMIS_LINC00343|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

DCHS2 GRM1 PTER PCDH17 CNTN6 NWD2 PTPRK

1.61e-061791407065a50952e8703fa07767beb6b73a090bf378ca6
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)-Glut_D_(IT_RORB_THEMIS_LINC00507)_6|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

DCHS2 GRM1 PTER PCDH17 CNTN6 NWD2 PTPRK

1.80e-06182140731efc06d6b073e8e341648207093e5f33c6f9183
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

DCHS2 GRM1 PTER PCDH17 CNTN6 NWD2 PTPRK

1.87e-06183140701ad18f198195ce341bae01a1c8c253cc4607766
ToppCellwk_20-22-Mesenchymal-Chondrocyte-intermediate_chondrocyte|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

COL6A6 TRPS1 RFTN2 LIG1 XPO5 PCDH19 C1GALT1C1L

1.87e-0618314071464b5c4425e8776c4aeb4d2b560481d4bf13931
ToppCellPND10-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC-AEC_prolif|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

FLNB RPS6KA2 ITPR3 STK3 MRM3 SLC35G3 NEK8

2.01e-06185140787151ab95530e70d61328b336518df58db584acb
ToppCellLPS-IL1RA+antiTNF-Epithelial_alveolar-AT_1-Differentiating_AT1|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

LAMA3 RAB11FIP1 CNTN6 SLC6A6 MYOF CELSR1 CACNA2D3

2.08e-0618614073aebe163799109ffc67e4e10ee47c2dd0886a92c
ToppCellFetal_29-31_weeks-Epithelial|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

LAMA3 BTBD9 RAB11FIP1 ITPR3 CELSR1 PTPRK ROS1

2.66e-061931407a0ca3231992f14abcf1a6129573bace320e89d2a
ToppCelldroplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COL6A6 ACLY RPS6KA2 SLC6A6 CLK1 BOD1L1 PC

2.85e-0619514073e519cffa6144a62b06124642a14c9ff39b76554
ToppCelldroplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COL6A6 ACLY RPS6KA2 SLC6A6 CLK1 BOD1L1 PC

2.85e-0619514077796ea9247f4c63762f0de8490fed08b9717fa23
ToppCellThalamus-Endothelial-ENDOTHELIAL_STALK-Flt1_2|Thalamus / BrainAtlas - Mouse McCarroll V32

COL6A6 LAMA3 ITPR3 MYOF SH3TC1 CDH5

4.04e-06133140629b0c2c682c6b97823e7d8d8ba1f5114044b30ba
ToppCellprimary_visual_cortex-Neuronal-glutamatergic_neuron-L2/3_IT-L2/3_IT_VISp_Adamts2|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

RPS6KA2 PTER NWD2 PTPRK PCDH19 DCLK3

1.01e-0515614062cd007b423c2395c5ce331902e7f27c805755eb3
ToppCell368C-Endothelial_cells-Endothelial-C_(Capillary_Aerocyte_)|368C / Donor, Lineage, Cell class and subclass (all cells)

DCHS2 RPS6KA2 PCDH17 TRIM16 LOXHD1 CDH5

1.44e-05166140630a991fc3275b571d53bd0976df4789e5d40b01d
ToppCell368C-Endothelial_cells-Endothelial-C_(Capillary_Aerocyte_)-|368C / Donor, Lineage, Cell class and subclass (all cells)

DCHS2 RPS6KA2 PCDH17 TRIM16 LOXHD1 CDH5

1.44e-05166140676b4cd32698900797ec009f17e50ea7ae36b85f4
ToppCellASK440-Immune-B_cell|Immune / Donor, Lineage and Cell class of Lung cells from Dropseq

ZFAT EAF2 COL6A6 PTPRK CDH5 IPO11

1.54e-051681406127559d1a083c68cda9fce143afcc3eec168df17
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT2_L6_FEZF2|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

DCHS2 PCDH17 MYOF CDH24 KCNK2 ROS1

1.59e-0516914060c341f91dc21aaf92bead18d59684d11510502ce
ToppCellfacs-Large_Intestine-Proximal-18m-Epithelial-Lgr5+_undifferentiated_cell_(Distal)|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MYO1G LRRC49 BTBD10 PHLDA3 PTER MRM3

1.64e-05170140645de83a2231208b8e1f21061d0b91644b4a3ba93
ToppCell3'-GW_trimst-1.5-LargeIntestine-Mesenchymal-fibroblastic-Stromal_1_(ADAMDEC1+)|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

COL7A1 CSMD3 HNRNPA1 HSPA12A VCAN PJA1

1.64e-051701406b5b47fe42617a4c2ebb49c8ed55db3926213a75a
ToppCellPND07-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC-AEC_prolif|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

FLNB PIGG PTER ITPR3 SH3TC1 PLD1

1.82e-0517314064968712af1cca8c932abd3323631d7dcaffd4a66
ToppCelldroplet-Mammary_Gland-nan-3m-Endothelial-nan|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ZFAT PCDH17 SEMA4C SH3TC1 MICAL3 CDH5

1.82e-051731406fbc8ed566ea36c39c258dd6b3823c82f5d6eb17f
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

GRM1 PTER PCDH17 CNTN6 NWD2 PTPRK

1.88e-051741406bc978a2148a0261a4f9d1ca5479b707e224566be
ToppCellILEUM-inflamed-(3)_pDC|inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

FLNB ZFAT RAB11FIP1 SH3TC1 NEK8 EPHB1

2.00e-051761406b9f847dd55703e413f3cd815eef5724fffaf13b3
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

DCHS2 GRM1 PTER CNTN6 NWD2 PTPRK

2.07e-051771406f30d757ee8db7e10d547498dab6560473c6ed7c0
ToppCell3'-GW_trimst-2-LargeIntestine-Endothelial-lymphatic_endothelial-LEC2_(MADCAM1+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

DCHS2 TNFSF18 RPS6KA2 CELSR1 SH3TC1 CDH5

2.07e-051771406d6596a0b6fd146fefc27717c1a7dbaa3774cc644
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)-Glut_D_(IT_RORB_THEMIS_LINC00507)_6|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

DCHS2 GRM1 PTER PCDH17 CNTN6 PTPRK

2.20e-051791406445eeb0356d9fd894aa33dd9f45d893b21424149
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L2-6_VIP_VIP|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

LAMA3 CNTN6 LOXHD1 VCAN PCDH19 KCNK2

2.20e-05179140601302505816f272243659e20d751b61a198a2fc0
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L2-6_VIP_VIP|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

LAMA3 LOXHD1 VCAN PCDH19 KCNK2 EPHB1

2.27e-051801406c6030e725e3d86d5d74a1676330c77ffeceb324f
ToppCell10x_3'_v3-blood_(10x_3'_v3)-myeloid-myeloid_monocytic-non-classical_monocyte|blood_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

CDH23 CSMD2 HSPA12B CSMD3 CTSL

2.34e-051081405695ed3f8cf637d767a6d79b0309d5ee82dfd063f
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)-Glut_D_(IT_RORB_THEMIS_LINC00507)_6-Exc_L6_THEMIS_LINC00343|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

DCHS2 GRM1 PTER CNTN6 NWD2 PTPRK

2.42e-051821406cc6f9d606a4f8717dc44928ceec2a257636043fd
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

GRM1 PTER PCDH17 CNTN6 NWD2 PTPRK

2.42e-051821406205d9ad1ea4b7adee8054496cdde46c9c401a19a
ToppCellBasal|World / shred by cell class for mouse tongue

COL7A1 LAMA3 PAICS SLC6A6 CELSR1 SLC12A4

2.49e-051831406c6729a207526ff4aa48176207b9353176f631fea
ToppCellmyeloid-pDC|World / Lineage and Cell class

FLNB ZFAT CDH23 RAB11FIP1 NEK8 EPHB1

3.08e-05190140688c42779ce2f817d28e672d83f3f1158581edf73
ToppCellFetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)-D062|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

RPS6KA2 LAMA3 BTBD9 RAB11FIP1 ITPR3 PTPRK

3.26e-05192140629f49f00770c991b5f27e4cb701dd2d2d6cb7178
ToppCelldroplet-Lung-nan-18m-Endothelial-Capillary_Aerocyte_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PHLDA3 PCDHAC2 HSPA12B TRIM16 ASNS CDH5

3.46e-051941406f35f03412b596b6b570b377ba1a607409d984bb1
ToppCell3'-GW_trimst-2-LargeIntestine-Mesenchymal-fibroblastic-Stromal_1_(ADAMDEC1+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CSMD3 HNRNPA1 HSPA12A VCAN PJA1 HSPA5

3.66e-051961406a7adc0e0baef261d0937e4e8351321d41beca82f
ToppCellLPS_IL1RA-Epithelial_alveolar-AT_1-Differentiating_AT2|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

LAMA3 CSMD2 MYOF CELSR1 IFT80 HSPA5

3.76e-051971406b94645d57efe8d9e032bffb8c89af1f425c6421e
ToppCellfacs-Tongue-nan-3m-Epithelial-basal_cell_of_epidermis|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TRPS1 LAMA3 PAICS SLC6A6 CELSR1 SLC12A4

3.87e-05198140622559b161e67b49fe8028bfaf861e069063599f5
ToppCell(03)_KRT6B+|World / shred by cell type by condition

RPS6KA2 RAB11FIP1 TRIM16 PTPRK ASNS TRIM16L

3.98e-0519914069feaf8649b3f68f30b8cb6b045a2caa2dd343c7f
ToppCellLPS_anti-TNF-Epithelial_alveolar-AT_1-Differentiating_AT1|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

LAMA3 CNTN6 MYOF CELSR1 IFT80 CACNA2D3

3.98e-051991406d43c605a4ff221cf78d91678c15d2ad20f831c7f
ToppCellLPS_IL1RA_TNF-Epithelial_alveolar-AT_1|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

LAMA3 CNTN6 MYOF CELSR1 IFT80 CACNA2D3

3.98e-0519914061c70e7d6bd25980e1b92aa1cac3f3c95d9651b4b
ToppCellNeuronal-Excitatory-eC(RORB)-eC_1-CARM1P1--L3-4|Neuronal / cells hierarchy compared to all cells using T-Statistic

TRPS1 GRM3 CDH20 PTPRK ROS1 PLD1

4.10e-05200140647791c93d03ee17c1ce17e27f075be4fc6f2590e
ToppCellLPS_IL1RA_TNF-Epithelial_alveolar-AT_1-Differentiating_AT1|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

LAMA3 CNTN6 MYOF CELSR1 IFT80 CACNA2D3

4.10e-052001406ddfb1f006365bf16203ee49f20200f68220cc288
ToppCellLPS_only-Endothelial|LPS_only / Treatment groups by lineage, cell group, cell type

FLNB RPS6KA2 YBX3 HSPA12B PCDH17 CDH5

4.10e-05200140681e76508c9050d533853d5fd2f3097b27613d836
ToppCellNeuronal-Excitatory-eE(FEZF2_SLC17A7)-eE_2-SLC17A7_IL15-|Neuronal / cells hierarchy compared to all cells using T-Statistic

DCHS2 MYOF CDH24 VCAN KCNK2 ROS1

4.10e-05200140648fd48990a6833066be314dc5b66b90893f7ea8f
ToppCellLPS_IL1RA_TNF-Endothelial-Endothelial-Artery|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

FLNB RPS6KA2 YBX3 HSPA12B ASNS CDH5

4.10e-05200140677ae679c35d3b9e2b620f34129f3a8d47e922c65
ToppCellLPS_anti-TNF-Epithelial_alveolar-AT_1|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

LAMA3 CNTN6 MYOF CELSR1 IFT80 CACNA2D3

4.10e-0520014068683445ad5b70748c4a1f12eb77d47623085147e
ToppCellcritical-Myeloid-Non-resident_Macrophage|Myeloid / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

YBX3 MYOF VCAN CTSL METAP2 DYNC1I2

4.10e-052001406f9acaaba67af88b1a93d2ef46ceba7705f35de63
ToppCellLPS_IL1RA-Endothelial-Endothelial-Artery|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

FLNB RPS6KA2 YBX3 HSPA12B ASNS CDH5

4.10e-052001406ac9ead34afa14067171833f5c277eaf06db7b02e
ToppCellNeuronal-Excitatory-eC(RORB)-eC_1-CARM1P1|Neuronal / cells hierarchy compared to all cells using T-Statistic

TRPS1 GRM3 CDH20 PTPRK ROS1 PLD1

4.10e-052001406f75d95376a340d467c4392b872b2a2dbdd184556
ToppCellNeuronal-Excitatory-eC(RORB)-eC_1-CARM1P1-|Neuronal / cells hierarchy compared to all cells using T-Statistic

TRPS1 GRM3 CDH20 PTPRK ROS1 PLD1

4.10e-052001406fae26560ba3b0b638b6bcf92f05330824b31d21b
ToppCellNeuronal-Excitatory-eE(FEZF2_SLC17A7)-eE_2-SLC17A7_IL15--L5-6|Neuronal / cells hierarchy compared to all cells using T-Statistic

DCHS2 MYOF CDH24 VCAN KCNK2 ROS1

4.10e-0520014069103e6f72a04f66f2b7069b0d71a719e9b10026b
ToppCellLPS_only-Endothelial-Endothelial-Artery|LPS_only / Treatment groups by lineage, cell group, cell type

FLNB RPS6KA2 YBX3 HSPA12B ASNS CDH5

4.10e-052001406b17eb1587ca86c3d40515128a00a8d8fd787fccf
ToppCellNeuronal-Excitatory-eE(FEZF2_SLC17A7)-eE_2|Neuronal / cells hierarchy compared to all cells using T-Statistic

DCHS2 MYOF CDH24 VCAN KCNK2 ROS1

4.10e-052001406d31e26387d879ee30731c497cea6aaf4746e40d9
ToppCellLPS_anti-TNF-Endothelial-Endothelial-Artery|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

FLNB RPS6KA2 YBX3 HSPA12B ASNS CDH5

4.10e-052001406b1ff8d61b567f85006d6d20093f9c803b6d34674
ToppCellLPS_only-Endothelial-Endothelial|LPS_only / Treatment groups by lineage, cell group, cell type

FLNB RPS6KA2 YBX3 HSPA12B PCDH17 CDH5

4.10e-0520014064bb609a284d4e6066f17470a1736076aa4a1f84c
ToppCellNeuronal-Excitatory-eE(FEZF2_SLC17A7)-eE_2-SLC17A7_IL15|Neuronal / cells hierarchy compared to all cells using T-Statistic

DCHS2 MYOF CDH24 VCAN KCNK2 ROS1

4.10e-052001406e5e97767beb4413e87c9817a60a5f1ee5209198a
ToppCellprimary_visual_cortex-Neuronal-GABAergic_neuron-Pvalb-Pvalb_Gabrg1|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

LAMA3 SLC36A2 PCDH17 MYOF PTPRK

8.08e-0514014052c44e8cc5190226049be7ebc465d685393e701c4
ToppCell3'_v3-blood-Lymphocytic_Invariant-Inducer-like-MAIT|blood / Manually curated celltypes from each tissue

COL7A1 GARNL3 LAMA3 CSMD3 ITPR3

8.64e-0514214051175d4390d204ffa3a2d2fe24486f85d3b639b72
ToppCellGlobus_pallidus-Endothelial-ENDOTHELIAL_STALK|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

RAB11FIP1 HSPA12B TRIM16 SH3TC1 CDH5

1.08e-041491405d9c47f523c75ddcd6131e45d2ffc24b970932cae
ToppCellprimary_visual_cortex-Neuronal-glutamatergic_neuron-L5_IT-L5_IT_VISp_Col27a1|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

TRPS1 PTPRK KCNK2 PLD1 EPHB1

1.27e-041541405d22902d2922784583f7016453768ed05b14b965e
ToppCellprimary_visual_cortex-Neuronal-glutamatergic_neuron-L2/3_IT-L2/3_IT_VISp_Agmat|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

RPS6KA2 PTER NWD2 PTPRK DCLK3

1.34e-04156140509e0702400570089d9012dcf94dfb4827c97e49d
ToppCellfrontal_cortex-Neuronal-GABAergic_neuron-Lamp5-Lamp5_Plch2_Dock5|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

SPOCK1 PCDH17 CDH24 CDH20 VCAN

1.39e-041571405516903469756c5fabfdf56d7bd59b3bdd7b44e39
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT2_L6_FEZF2-Exc_L6_FEZF2_TBC1D26|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

DCHS2 MYOF CDH24 KCNK2 ROS1

1.43e-0415814053d6295fe25e3b1fb4b6e83704c5bdbf86dc639b3
ToppCelldroplet-Liver-LIVER_HEP-30m-Myeloid-myeloid_leukocyte|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MYO1G GARNL3 TNFSF18 TRPS1 KCNK2

1.43e-04158140591d265e95156f16459924d3e4dd11c180e164eee
ToppCellTCGA-Skin-Metastatic-Melanoma-Skin_Cutaneous_Melanoma-3|TCGA-Skin / Sample_Type by Project: Shred V9

GARNL3 RFTN2 HNRNPA1 DMXL1 FEM1B

1.47e-041591405fb222c42f66901852b01cec073ec0732245ee973
ToppCell(04)_Pre-ciliated-(2)_48hpi|(04)_Pre-ciliated / shred by cell type and Timepoint

PHB2 PAICS SLC6A6 LIG1 MYOF

1.47e-041591405e1f36b237e314ef6a18224eb8f3b97a612c39506
ToppCellEntopeduncular-Endothelial-ENDOTHELIAL_STALK|Entopeduncular / BrainAtlas - Mouse McCarroll V32

RAB11FIP1 ITPR3 TRIM16 SH3TC1 CDH5

1.51e-04160140504714d0b9bad4c11fa193ed168e2d84a4df39e2e
ToppCellprimary_visual_cortex-Neuronal-glutamatergic_neuron-L2/3_IT|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

RPS6KA2 PTER NWD2 PTPRK DCLK3

1.56e-041611405e3327c296d48e821004e61a573abb75624a6f040
ToppCellprimary_visual_cortex-Neuronal-glutamatergic_neuron-L6_CT-L6_CT_VISp_Ctxn3_Brinp3|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

GARNL3 CDH24 SLC12A4 KCNK2 EPHB1

1.65e-041631405b0aa4a620bd58011225b42ea6dda04e3101ba342
ToppCell356C-Endothelial_cells-Endothelial-F_(Lymphatics)-|356C / Donor, Lineage, Cell class and subclass (all cells)

FLNC HSPA12B CDH5 IPO11 EPHB1

1.80e-0416614055ba45407a47207ff01e4a3f9f5d91d8247fe9b6f
ToppCellwk_08-11-Mesenchymal-Fibroblast-Alveolar_fibro|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

DCHS2 PCDHB6 PTER NEK8 VCAN

1.80e-04166140565dafed953b01a9830b54309af75c7a561e88336
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT2_L6_FEZF2-Exc_L6_FEZF2_TBCC|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

DCHS2 MYOF CDH24 VCAN KCNK2

1.80e-04166140536c443c9df9ed09fdede67df6f71eed1cca9cff1
ToppCell356C-Endothelial_cells-Endothelial-F_(Lymphatics)|356C / Donor, Lineage, Cell class and subclass (all cells)

FLNC HSPA12B CDH5 IPO11 EPHB1

1.80e-0416614056bd5aa205b6e4b88ba9f8cd0999e2191d7d1d16c
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT2_L6_FEZF2|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

DCHS2 MYOF CDH24 KCNK2 ROS1

1.85e-041671405a6ff7a3d9b80839c0efa91658836812e868561fa
ToppCellVE-Treg-exh_CD4|VE / Condition, Cell_class and T cell subcluster

BTBD9 CDH20 SLC12A4 PJA1 TACC3

1.85e-0416714051036ac1ef9440612500137af9d1929672b077e4d
ToppCellControl|World / group, cell type (main and fine annotations)

LAMA3 RAB11FIP1 PTPRK ROS1 CACNA2D3

1.90e-041681405a3511faf2cd2c2b9c8363c8b99da3f3609c43ed6
ToppCell(3)_DC_plasmacytoid|World / Lung cell shreds - cell class (v4) and cell subclass (v4)

FLNB ZFAT RAB11FIP1 NEK8 EPHB1

1.90e-0416814058a913db9b2a1a4ff96fb139734a3834e6aa263f1
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT2_L6_FEZF2-Exc_L6_FEZF2_SLITRK6|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

DCHS2 MYOF CDH24 VCAN KCNK2

1.95e-0416914051c9e54e7b14eb99996590fb93b257cf881a9f184
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT2_L6_FEZF2-Exc_L6_FEZF2_ETV4|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

DCHS2 TRPS1 PCDH17 CDH24 ROS1

1.95e-041691405716e9d4c5fb99c56b76afaa5ed90bfa859fde802
ToppCell5'-Adult-LargeIntestine-Mesenchymal-fibroblastic-Stromal_1_(ADAMDEC1+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

COL7A1 RPS6KA2 MYOF VCAN PCDH19

1.95e-041691405c0824a93674e2bff0f09b2d2fab5bab016a2e379
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT2_L6_FEZF2-Exc_L6_FEZF2_TBC1D26|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

DCHS2 MYOF CDH24 KCNK2 ROS1

1.95e-0416914052abdd8ae9a5d88aac30992142d1b502c959bc015
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Endothelial-lymphatic_endothelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

FLNC RPS6KA2 CATSPERB CDH5 EPHB1

2.01e-0417014056035c92cd39c5ac54e7ec57d94888ee19f574639
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_medulla|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

FLNC RPS6KA2 CATSPERB CDH5 EPHB1

2.01e-041701405c8c42eda44b61440c96b202e7f54650046eb95d3
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_medulla-lymphatic_endothelial_cell_of_renal_medulla|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

FLNC RPS6KA2 CATSPERB CDH5 EPHB1

2.01e-041701405dcc64b73134e89ae37990d4878813b86ce91dae9
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT2_L6_FEZF2|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

DCHS2 MYOF CDH24 KCNK2 ROS1

2.12e-041721405cecfe5cf20f317ea01b4604789e07a14481c4cd6
ToppCellE12.5-Endothelial-proliferative_endothelial_cell-proliferative_endothelial_cell|E12.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

PCDH17 TRIM16 SH3TC1 CDH5 IPO11

2.12e-041721405ba99688e9f46671deccf824b1e77c6db0742d7df
ToppCellE12.5-Endothelial-proliferative_endothelial_cell|E12.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

PCDH17 TRIM16 SH3TC1 CDH5 IPO11

2.12e-0417214052136170f6e1204734cec7dbf7b32e7d5179b92b5
ToppCellPND01-03-samps-Endothelial-Postnatal_endothelial-endothelial_cells_D|PND01-03-samps / Age Group, Lineage, Cell class and subclass

PCDH17 SH3TC1 IFT80 CDH5 EPHB1

2.23e-041741405b4f3f5334803e5903bc496decf923f2e44f7fa3c
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT2_L6_FEZF2-Exc_L6_FEZF2_TBCC|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

DCHS2 MYOF CDH24 VCAN KCNK2

2.23e-041741405912a9e892b29d945666fc37c986009c97c668ac8
ToppCell3'-GW_trimst-2-LargeIntestine-Hematopoietic-Myeloid-pDC|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ZFAT CDH23 RAB11FIP1 NEK8 CACNA2D3

2.23e-0417414054120656e6d6cf5435a248326b5fdbdc7b22137af
ToppCellLPS-IL1RA+antiTNF-Epithelial_alveolar-AT_1-AT2_Progenitor|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

LAMA3 RAB11FIP1 CNTN6 CELSR1 CACNA2D3

2.23e-041741405d0e3d15731de6c19c232e3aa492c39d8151cf4ed
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

DCHS2 MYOF CDH24 KCNK2 ROS1

2.23e-041741405e4d65fe121a32ac4cdd6312e7b8f867f0852e991
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT2_L6_FEZF2|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

DCHS2 PCDH17 MYOF CDH24 ROS1

2.23e-0417414057d4b860e05b5931f6f9d757a68f75ff35597a47a
ToppCell10x5'-blood-Lymphocytic_T_CD4-Tfh|blood / Manually curated celltypes from each tissue

B3GALNT2 HNRNPA1L3 SEMA4C PJA1 EPHA1

2.29e-041751405d7e24ac683ff36f7ce3d1151353d3d4a6f2b63bf
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)-Glut_D_(IT_RORB_THEMIS_LINC00507)_6|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

DCHS2 GRM1 PTER CNTN6 PTPRK

2.36e-0417614050710689e66deba179b0a8038cdd56b4834984f12
ToppCellE16.5-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

FLNB HSPA12B SLC6A6 SLC35G3 CDH5

2.36e-04176140577516048aefbe1f48e825052756df0c310c1c486
ToppCelldroplet-Marrow-BM-1m-Lymphocytic-late_pro-B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ERCC6 EAF2 SEMA4C ITPR3 RAB11FIP3

2.36e-0417614052e9073166da4d9fae70ba4f3fdcad35523caf7cd
ToppCellE16.5-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC-AEC_mature|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

FLNB HSPA12B SLC6A6 SLC35G3 CDH5

2.36e-04176140596779273b94345250cf53ba671203345b43d9e00
ToppCellE18.5-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC-AEC_mature|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

FLNB HSPA12B ITPR3 SLC6A6 CDH5

2.36e-04176140527e6b3ae41068d6cfdda3d46da7df2a27567140e
Druggadolinium

GALC TRPM7 CDH23 GRM1 GRM3 ITPR3 AGL KCNK2 TACC3 CACNA2D3

4.16e-0719913910CID000023982
Diseasemyopathy (implicated_via_orthology)

FLNB FLNC HNRNPA1L2 HNRNPA1 HNRNPA1L3

3.03e-06481385DOID:423 (implicated_via_orthology)
Diseasemyofibrillar myopathy 5 (implicated_via_orthology)

FLNB FLNC

6.49e-0531382DOID:0080096 (implicated_via_orthology)
Diseasedistal muscular dystrophy 4 (implicated_via_orthology)

FLNB FLNC

6.49e-0531382DOID:0111190 (implicated_via_orthology)
DiseaseCiliopathies

MKKS CDH23 NPHP4 NEK8 IFT80

1.72e-041101385C4277690
Diseasecortical thickness

FLNB RPS6KA2 LRRC49 TRPS1 HNRNPA1L3 PCDH17 CELSR1 CDH20 ADAMTS7 XPO5 VCAN KCNK2 MICAL3 TACC3 CACNA2D3

2.32e-04111313815EFO_0004840
Diseaselimb-girdle muscular dystrophy (implicated_via_orthology)

MYOF FER1L5

4.49e-0471382DOID:11724 (implicated_via_orthology)
Diseasepneumococcal meningitis

CELSR1 ROS1

5.97e-0481382EFO_1001114
Diseaseneurodegenerative disease (implicated_via_orthology)

HNRNPA1L2 HNRNPA1 HNRNPA1L3 STK3 TRAK2

6.14e-041451385DOID:1289 (implicated_via_orthology)
DiseaseNephronophthisis

NPHP4 NEK8

7.65e-0491382cv:C0687120
Diseaseciliopathy (implicated_via_orthology)

MKKS NPHP4 IFT80

8.71e-04401383DOID:0060340 (implicated_via_orthology)
Diseaseasparagine measurement

CNTN6 TIMM21 ASNS

9.37e-04411383EFO_0009766
Diseasereaction time measurement

MYO1G ZFAT YBX3 STK31 HNRNPA1L3 PCDH17 TRIM16 PTPRK PC DYNC1I2

1.09e-0365813810EFO_0008393
Diseasebrain measurement, neuroimaging measurement

DCHS2 TRPS1 RFTN2 HNRNPA1L3 VCAN KCNK2 CATSPERB TACC3 METAP2

1.17e-035501389EFO_0004346, EFO_0004464
DiseaseGastric Adenocarcinoma

TRPM7 ROS1 EPHB1

1.23e-03451383C0278701
Diseasecaudate nucleus measurement, functional brain measurement, response to reward

CSMD3 CNTN6 CELSR1

1.40e-03471383EFO_0007849, EFO_0008387, EFO_0008396
DiseaseNephronophthisis

NPHP4 NEK8

1.64e-03131382C0687120
DiseaseColorectal Carcinoma

FLNC COL7A1 ERCC6 TRPM7 GRM1 CSMD3 LIG1 SH3TC1 CDH5 EPHA1

1.76e-0370213810C0009402
DiseaseColorectal Neoplasms

FLNC COL7A1 TRPM7 SH3TC1 CDH5 EPHA1

1.98e-032771386C0009404
Diseaseinherited metabolic disorder (is_implicated_in)

NDUFS2 LIG1

2.19e-03151382DOID:655 (is_implicated_in)
Diseaseoptic cup area measurement

FLNB HNRNPA1L3 HSPA12A

2.31e-03561383EFO_0006940
Diseasecathepsin L1 measurement

GRM1 CTSL

2.50e-03161382EFO_0010619
Diseasefood allergy measurement, parental genotype effect measurement

DCHS2 EML6

3.16e-03181382EFO_0005939, EFO_0007016
Diseaseosteochondrodysplasia (is_implicated_in)

FLNB TRPS1

3.52e-03191382DOID:2256 (is_implicated_in)
DiseaseHIV-1 infection, Susceptibility to viral and mycobacterial infections

SPOCK1 PC

4.30e-03211382EFO_0000180, Orphanet_391311
DiseaseInfiltrating duct carcinoma of female breast

TRPM7 DCLK3

4.30e-03211382C3165106
Diseasevisceral:subcutaneous adipose tissue ratio

ZFAT CNTN6 EPHB1

4.36e-03701383EFO_0004767
Diseaseneuroimaging measurement

DCHS2 LRRC49 TRPS1 HNRNPA1L3 CELSR1 VCAN KCNK2 PLD1 TACC3 PC METAP2 IPO11

4.48e-03106913812EFO_0004346

Protein segments in the cluster

PeptideGeneStartEntry
IFSGEGSDELTQGYI

ASNS

361

P08243
VDTVIGEGEFGEVYR

EPHA1

626

P21709
KGEYEVAEGIGSTVF

BTBD10

211

Q9BSF8
RVGVFLDYEGGTISF

BTNL3

406

Q6UXE8
TVGLGDAISAEGLFY

ADPGK

476

Q9BRR6
AFVYSEGQSETILGG

AKR7A3

46

O95154
LGFIVDTIVDGVYIG

CATSPERB

196

Q9H7T0
DTIVDGVYIGITFGG

CATSPERB

201

Q9H7T0
FDLERGYDTLTVGDG

CSMD2

451

Q7Z408
LEIGYDTLTIGDGGE

CSMD3

596

Q7Z407
DGVVTVDDLRGVYSG

CAPS

196

Q13938
ELVTTGHYGFTLGEE

VCAN

541

P13611
ERYEIVSTLGEGTFG

CLK2

161

P49760
VHVCGEGGEYETFTL

DPH6

196

Q7L8W6
VASEGDYGETGIEAF

GRM3

216

Q14832
GETIYVIGQGSDGTE

GTPBP1

91

O00178
STDTVYDVVVSGGGL

COQ6

31

Q9Y2Z9
DGDGDFYIEPTSGVI

CELSR1

936

Q9NYQ6
GEYVGKVFRVDAETG

CDH5

86

P33151
KGDFYTLTVVADDGG

CDH23

1381

Q9H251
VDPTEEYFVTGSAEG

DMXL1

2936

Q9Y485
SGGGVTPLVEYEDVS

CDK13

136

Q14004
GGDGEVEEYLSFRSV

ERCC6

36

Q03468
SGTFEEAEGLGYVDV

ADAMTS7

701

Q9UKP4
YEIVDTLGEGAFGKV

CLK1

161

P49759
IIVGFDDGSIGIYTV

NWD2

1631

Q9ULI1
GFGFVTYATVEEVDA

HNRNPA1L2

56

Q32P51
GFGFVTYATVEEVDA

HNRNPA1L3

11

A0A2R8Y4L2
EGYVLTAVEGTIGDF

NOMO3

856

P69849
DFGESGRLTYEIVDG

PCDH17

616

O14917
SLEGFFIYEEEGSGV

RFTN2

316

Q52LD8
ITVIGGEEHFEDYGE

RAB11FIP3

381

O75154
GDIVSLYAEGSVNGF

ITPR3

11

Q14573
GGDGEVEEYLSFRSV

ERCC6

36

P0DP91
GLVTVTGALDYEEGH

PCDH19

296

Q8TAB3
IEEVIGAGEFGEVYK

EPHB1

621

P54762
EIIETIGNGAYGVVS

MAPK7

56

Q13164
EGYVLTAVEGTIGDF

NOMO2

856

Q5JPE7
YVAGGLGETEDLLSF

KLHL33

421

A6NCF5
GEGTVVVSYGVSLEN

MKKS

256

Q9NPJ1
VSEYEFEVIIGGDGR

MICAL3

211

Q7RTP6
EEGEVYAIETFGSTG

METAP2

356

P50579
EKGIYFSEEGGHVVL

LAMA3

3156

Q16787
YDIIEVLGKGTFGEV

HIPK4

11

Q8NE63
TTGYEEAAAQGVIAG

MTO1

436

Q9Y2Z2
ESYTVLGDTLIDGGE

FSD1

341

Q9BTV5
LEFSVSYVFTEVGEG

IPO11

296

Q9UI26
VVYEAGVFSVTAGDG

DPYS

446

Q14117
VITLTTIGFGDYVAG

KCNK2

261

O95069
TIGFGDYVAGGSDIE

KCNK2

266

O95069
VKVYTGDVIGAGTDA

LOXHD1

176

Q8IVV2
TYEIVIETGNGGETR

LOXHD1

1811

Q8IVV2
EVIVTTGYEPGAGTD

LOXHD1

1951

Q8IVV2
AVGDSEGQIVIYDVG

DYNC1I2

586

Q13409
YETGRVIGDGNFAVV

DCLK3

356

Q9C098
LDSGAAGIYTEDITG

DSG4

596

Q86SJ6
TGTVRFDGYVIDGAT

FEM1B

76

Q9UK73
YLLTGEGAGTVFVID

CDH24

81

Q86UP0
SDFIVDTRDAGYGGI

FLNB

2021

O75369
REFEEVLAISGGIYG

NAT16

61

Q8N8M0
YTAGAGTGDVAVVIV

FLNC

401

Q14315
EGYVLTAVEGTIGDF

NOMO1

856

Q15155
GDAFTVAIGAESEVY

NEK8

621

Q86SG6
FGLGEVDDKIYVVAG

KLHL41

391

O60662
VEVDGDTLSLYGSGA

LRRC49

411

Q8IUZ0
YVVVDSGGGTVDLTV

HSPA12A

311

O43301
YVVADCGGGTVDLTV

HSPA12B

316

Q96MM6
EDKVIAVYDLGGGTF

HSPA9

236

P38646
AVYDLGGGTFDISIL

HSPA9

241

P38646
AVAYGVRESVFTVEG

PHB2

31

Q99623
GVVTAEEALNYGFSG

NDUFS2

276

O75306
EDSFQVGGGETYTIG

NPHP4

1376

O75161
ETGVHIISGAGFYVD

PTER

116

Q96BW5
GDAAYFAVEELSGVV

DCHS2

351

Q6V1P9
DASTGEVRVIGGLDY

PCDHAC2

311

Q9Y5I4
TGLVGGSYDVLVSGE

BOD1L1

2001

Q8NFC6
YEGTALVTVGEDGQI

IFT80

116

Q9P2H3
SSEGYLEVGEGEQVT

EAF2

46

Q96CJ1
YTQTGDFFGEIEGAV

CACNA2D3

871

Q8IZS8
YILSGEGAGIVFTID

CDH20

96

Q9HBT6
EGVEGVAGGFIYTIQ

B3GALNT2

266

Q8NCR0
VAGGFIYTIQEGDAL

B3GALNT2

271

Q8NCR0
AVIGDVLQVYSGSEG

DDX50

376

Q9BQ39
VIFGDLEYVTVEGGI

C1GALT1C1L

171

P0DN25
YEFRVVAGNSIGIGE

CNTN6

671

Q9UQ52
GEPGDDFYIITEGTA

PRKAR1B

286

P31321
TDSAEIRGLEGGVSY

COL7A1

826

Q02388
TAGKEVVYFVAGVGV

EML6

31

Q6ZMW3
EGIFDYAAAIGGATI

HDAC8

106

Q9BY41
VIEGYEVEANGGITI

GRM1

326

Q13255
DVGTVVGIDLGTTYS

HSPA5

26

P11021
IGALLIGEEYGDVTF

BTBD9

26

Q96Q07
DGVGDTLDLVVIGAY

LIG1

751

P18858
VYIETPDTGGVFIAG

GALC

566

P54803
SLTIDGIRYVVDGGF

DHX40

351

Q8IX18
GGAIEEVYVSLGVSV

C8B

386

P07358
RQEGVIIYSVGVFGS

COL6A6

746

A6NMZ7
FVAAIDVYEDGEAGL

GARNL3

701

Q5VVW2
VIFEAEVSGGRSGYI

PTPRK

166

Q15262
EVSGGRSGYIAIDDI

PTPRK

171

Q15262
GYLVTKVVAVDGDSG

PCDHB6

581

Q9Y5E3
EAVGGFFSQIGELYV

NIPSNAP1

216

Q9BPW8
ISLVGAVDEEVGDYF

RSBN1L

466

Q6PCB5
GGTSDAYAVIQVGKE

RAB11FIP1

36

Q6WKZ4
QEGTTGVYTALGYVE

SLC35G3

181

Q8N808
VLGTGAEVDYLEQFG

TACC3

531

Q9Y6A5
FLEIIIGQYTSEGGI

SLC6A6

96

P31641
STGEEIEGVYSGFLP

FER1L5

416

A0AVI2
AAVVIGGETYGVSLE

MRM3

351

Q9HC36
DQSVAFVGGIDLAYG

PLD1

471

Q13393
GFVGFVVGTYQALDE

SLC36A2

451

Q495M3
VYFEEALGALEGSFG

SH3TC1

581

Q8TE82
LDGATYTVLFIGTGD

SEMA4C

431

Q9C0C4
IVGSVIQGSFLESYG

SLC12A4

726

Q9UP95
IYFTLVTEGGGEIDF

PHLDA3

71

Q9Y5J5
RTTDGVYEGVAIGGD

ACLY

676

P53396
HGVLVVGYGFESTES

CTSL

276

P07711
GTVIAQAEYGSVDIG

STK31

186

Q9BXU1
YEGDGIPTVFVAVAG

PAICS

316

P22234
YGAFTGESLAAEIEG

TRAK2

366

O60296
YDVQVTSGGTFIGIG

TRPS1

306

Q9UHF7
VFDVLEKLGEGSYGS

STK3

26

Q13188
EYDGFTITITGDKVG

TTC13

686

Q8NBP0
DVEGIETVTVYTQGG

ZFAT

1201

Q9P243
KGSQITYVTGVEGDD

ZNF143

466

P52747
YLRSVGDGETVEFDV

YBX3

131

P16989
GQYLVTGSVDGFIEV

SMU1

226

Q2TAY7
VGGTYELHVGDTIDL

TNFSF18

136

Q9UNG2
GAGVEFPEGLSIEEY

TIGD4

406

Q8IY51
FGSGGSVVLLDDLEY

SPOCK1

386

Q08629
LEEAKAGGFVVGYTS

XPO5

741

Q9HAV4
LGSGAFGEVYEGTAV

ROS1

1951

P08922
FGEVYEGTAVDILGV

ROS1

1956

P08922
FGVVFSEAYADGIEG

TAAR2

176

Q9P1P5
IGVFGESVKGYGEVT

TIMM21

156

Q9BVV7
FEVEIFGAGTYVGLT

TRIM16

431

O95361
LETEYQVIGGAGLDV

TMED1

56

Q13445
FGTAIYTEVVVDGEI

WWP1

36

Q9H0M0
VDISAGFVGLDTYVE

PIGG

866

Q5H8A4
GFGFVTYATVEEVDA

HNRNPA1

56

P09651
DGKTQDYVVGFTDLG

TXNDC9

151

O14530
GFADGLGVAEAISYV

PJA1

516

Q8NG27
AGGVVEAAISYTGDV

PC

696

P11498
ILVDDGTVGKYGAEV

TRPM7

246

Q96QT4
EVEIFGAGTYVGLTC

TRIM16L

216

Q309B1
NITAGVDEETGFVYG

AGL

1236

P35573
FTDGYEIKEDIGVGS

RPS6KA2

411

Q15349
GKDTVIGVLDIYGFE

MYO1G

386

B0I1T2
GQDTGATIDLVIGYD

MYOF

111

Q9NZM1