Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	amidine-lyase activity	CHAC2 PAM	1.44e-04	7	53	2	GO:0016842
GeneOntologyCellularComponent	gamma-secretase complex	APH1B PSENEN	1.26e-04	7	52	2	GO:0070765
GeneOntologyCellularComponent	somatodendritic compartment	TANC2 TIAM1 AGTR1 PENK PAM GRIA2 FEV MME GRM2 TENM2 TIAM2	1.79e-04	1228	52	11	GO:0036477
GeneOntologyCellularComponent	axon	TANC2 TIAM1 PENK INSRR GRIA2 MME GRM2 TENM2 TIAM2	3.15e-04	891	52	9	GO:0030424
GeneOntologyCellularComponent	actin-based cell projection	CLCA1 MYO1B MYO15A TENM2 TIAM2	6.26e-04	278	52	5	GO:0098858
GeneOntologyCellularComponent	dendrite	TANC2 TIAM1 AGTR1 PENK GRIA2 MME GRM2 TENM2	1.18e-03	858	52	8	GO:0030425
GeneOntologyCellularComponent	dendritic tree	TANC2 TIAM1 AGTR1 PENK GRIA2 MME GRM2 TENM2	1.20e-03	860	52	8	GO:0097447
GeneOntologyCellularComponent	extrinsic component of postsynaptic membrane	TIAM1 TENM2	1.36e-03	22	52	2	GO:0098890
GeneOntologyCellularComponent	cluster of actin-based cell projections	TIAM1 MYO1B MME MYO15A	2.29e-03	223	52	4	GO:0098862
GeneOntologyCellularComponent	perikaryon	PENK PAM GRIA2 TIAM2	2.29e-03	223	52	4	GO:0043204
GeneOntologyCellularComponent	dendritic spine	TANC2 TIAM1 GRIA2 TENM2	3.07e-03	242	52	4	GO:0043197
GeneOntologyCellularComponent	synaptic membrane	TIAM1 PSENEN GRIA2 ITGA5 GRM2 TENM2	3.14e-03	583	52	6	GO:0097060
GeneOntologyCellularComponent	growth cone	TIAM1 GRIA2 TENM2 TIAM2	3.21e-03	245	52	4	GO:0030426
GeneOntologyCellularComponent	postsynaptic membrane	TIAM1 GRIA2 ITGA5 GRM2 TENM2	3.28e-03	405	52	5	GO:0045211
GeneOntologyCellularComponent	neuron spine	TANC2 TIAM1 GRIA2 TENM2	3.30e-03	247	52	4	GO:0044309
GeneOntologyCellularComponent	extrinsic component of synaptic membrane	TIAM1 TENM2	3.43e-03	35	52	2	GO:0099243
GeneOntologyCellularComponent	filopodium	MYO1B TENM2 TIAM2	3.56e-03	123	52	3	GO:0030175
GeneOntologyCellularComponent	site of polarized growth	TIAM1 GRIA2 TENM2 TIAM2	3.60e-03	253	52	4	GO:0030427
GeneOntologyCellularComponent	neuronal cell body	TIAM1 PENK PAM GRIA2 FEV MME TIAM2	4.42e-03	835	52	7	GO:0043025
GeneOntologyCellularComponent	distal axon	TIAM1 PENK GRIA2 TENM2 TIAM2	4.44e-03	435	52	5	GO:0150034
GeneOntologyCellularComponent	cytoplasmic vesicle membrane	MRC1 APH1B SGIP1 CLCA1 PSENEN PAM GRIA2 MYO1B MME	4.56e-03	1307	52	9	GO:0030659
GeneOntologyCellularComponent	vesicle membrane	MRC1 APH1B SGIP1 CLCA1 PSENEN PAM GRIA2 MYO1B MME	4.99e-03	1325	52	9	GO:0012506
Domain	TPR_8	TANC2 IFIT1B IFIT1 ANAPC7	1.53e-05	53	53	4	PF13181
Domain	RBD	TIAM1 TIAM2	1.64e-04	7	53	2	SM00455
Domain	RBD_dom	TIAM1 TIAM2	1.64e-04	7	53	2	IPR003116
Domain	RBD	TIAM1 TIAM2	1.64e-04	7	53	2	PS50898
Domain	SOLCAR	SLC25A12 SLC25A2 SLC25A16	4.57e-04	53	53	3	PS50920
Domain	-	SLC25A12 SLC25A2 SLC25A16	4.57e-04	53	53	3	1.50.40.10
Domain	Mitochondrial_sb/sol_carrier	SLC25A12 SLC25A2 SLC25A16	4.57e-04	53	53	3	IPR018108
Domain	Mito_carr	SLC25A12 SLC25A2 SLC25A16	4.57e-04	53	53	3	PF00153
Domain	Mt_carrier_dom	SLC25A12 SLC25A2 SLC25A16	4.57e-04	53	53	3	IPR023395
Domain	TPR	TANC2 IFIT1B IFIT1 ANAPC7	4.89e-04	129	53	4	SM00028
Domain	TPR_repeat	TANC2 IFIT1B IFIT1 ANAPC7	5.49e-04	133	53	4	IPR019734
Domain	NHL	PAM TENM2	6.04e-04	13	53	2	PS51125
Domain	DH_1	TIAM1 PLEKHG7 TIAM2	7.60e-04	63	53	3	PS00741
Domain	TPR-contain_dom	TANC2 IFIT1B IFIT1 ANAPC7	8.62e-04	150	53	4	IPR013026
Domain	RhoGEF	TIAM1 PLEKHG7 TIAM2	9.49e-04	68	53	3	SM00325
Domain	RhoGEF	TIAM1 PLEKHG7 TIAM2	1.03e-03	70	53	3	PF00621
Domain	DH_2	TIAM1 PLEKHG7 TIAM2	1.03e-03	70	53	3	PS50010
Domain	DH-domain	TIAM1 PLEKHG7 TIAM2	1.08e-03	71	53	3	IPR000219
Domain	-	TIAM1 PLEKHG7 TIAM2	1.08e-03	71	53	3	1.20.900.10
Domain	TPR_REGION	TANC2 IFIT1B IFIT1 ANAPC7	1.23e-03	165	53	4	PS50293
Domain	TPR	TANC2 IFIT1B IFIT1 ANAPC7	1.23e-03	165	53	4	PS50005
Domain	PH_dom-like	TIAM1 DOCK11 PLEKHG7 MYO1B FRMD5 TIAM2	1.26e-03	426	53	6	IPR011993
Domain	-	TANC2 IFIT1B IFIT1 ANAPC7	2.81e-03	207	53	4	1.25.40.10
Domain	Aden_trnslctor	SLC25A12 SLC25A2	2.85e-03	28	53	2	IPR002113
Domain	Kringle-like	MRC1 F2	3.71e-03	32	53	2	IPR013806
Domain	Mit_carrier	SLC25A12 SLC25A16	3.71e-03	32	53	2	IPR002067
Domain	TPR-like_helical_dom	TANC2 IFIT1B IFIT1 ANAPC7	4.28e-03	233	53	4	IPR011990
Domain	-	TIAM1 DOCK11 PLEKHG7 FRMD5 TIAM2	4.93e-03	391	53	5	2.30.29.30
Domain	ANF_lig-bd_rcpt	GRIA2 GRM2	4.94e-03	37	53	2	IPR001828
Domain	ANF_receptor	GRIA2 GRM2	4.94e-03	37	53	2	PF01094
Domain	Myosin_head_motor_dom	MYO1B MYO15A	5.20e-03	38	53	2	IPR001609
Domain	MYOSIN_MOTOR	MYO1B MYO15A	5.20e-03	38	53	2	PS51456
Domain	Myosin_head	MYO1B MYO15A	5.20e-03	38	53	2	PF00063
Domain	MYSc	MYO1B MYO15A	5.20e-03	38	53	2	SM00242
Domain	GDS_CDC24_CS	TIAM1 TIAM2	5.47e-03	39	53	2	IPR001331
Domain	Peripla_BP_I	GRIA2 GRM2	5.47e-03	39	53	2	IPR028082
Domain	-	PAM TENM2	5.47e-03	39	53	2	2.120.10.30
Domain	PDZ	TIAM1 TIAM2 MAST3	7.49e-03	141	53	3	PF00595
Domain	FERM_M	MYO15A FRMD5	7.55e-03	46	53	2	PF00373
Domain	6-blade_b-propeller_TolB-like	PAM TENM2	7.55e-03	46	53	2	IPR011042
Domain	PH	TIAM1 DOCK11 PLEKHG7 TIAM2	7.94e-03	278	53	4	SM00233
Domain	PH_DOMAIN	TIAM1 DOCK11 PLEKHG7 TIAM2	8.04e-03	279	53	4	PS50003
Domain	PH_domain	TIAM1 DOCK11 PLEKHG7 TIAM2	8.14e-03	280	53	4	IPR001849
Pathway	REACTOME_SIGNALING_BY_GPCR	QRFP TIAM1 AGTR1 PENK ITGA5 GRM2 SSTR3 F2 RGS2 TIAM2	1.50e-05	702	39	10	M746
Pathway	REACTOME_SIGNALING_BY_GPCR	QRFP AGTR1 PENK ITGA5 GRM2 SSTR3 F2 RGS2 TIAM2	5.19e-05	646	39	9	MM14962
Pathway	REACTOME_CELL_DEATH_SIGNALLING_VIA_NRAGE_NRIF_AND_NADE	APH1B TIAM1 PSENEN TIAM2	5.56e-05	76	39	4	M19832
Pathway	REACTOME_P75_NTR_RECEPTOR_MEDIATED_SIGNALLING	APH1B TIAM1 PSENEN TIAM2	1.44e-04	97	39	4	M9400
Pathway	REACTOME_NONCANONICAL_ACTIVATION_OF_NOTCH3	APH1B PSENEN	1.55e-04	7	39	2	MM15612
Pathway	REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS	QRFP AGTR1 PENK SSTR3 F2	1.98e-04	197	39	5	M12289
Pathway	REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS	QRFP AGTR1 PENK SSTR3 F2	1.98e-04	197	39	5	MM14970
Pathway	REACTOME_NONCANONICAL_ACTIVATION_OF_NOTCH3	APH1B PSENEN	2.07e-04	8	39	2	M27887
Pathway	KEGG_REGULATION_OF_ACTIN_CYTOSKELETON	TIAM1 INSRR ITGA5 F2 TIAM2	2.85e-04	213	39	5	M18306
Pathway	PID_ANGIOPOIETIN_RECEPTOR_PATHWAY	AGTR1 ITGA5 F2	3.30e-04	49	39	3	M92
Pathway	REACTOME_TGFBR3_PTM_REGULATION	APH1B PSENEN	3.31e-04	10	39	2	MM17232
Pathway	REACTOME_REGULATED_PROTEOLYSIS_OF_P75NTR	APH1B PSENEN	3.31e-04	10	39	2	MM14744
Pathway	REACTOME_EPH_EPHRIN_MEDIATED_REPULSION_OF_CELLS	APH1B TIAM1 PSENEN	3.72e-04	51	39	3	M27311
Pathway	REACTOME_NOTCH4_ACTIVATION_AND_TRANSMISSION_OF_SIGNAL_TO_THE_NUCLEUS	APH1B PSENEN	4.04e-04	11	39	2	M27882
Pathway	REACTOME_TGFBR3_PTM_REGULATION	APH1B PSENEN	4.04e-04	11	39	2	M48251
Pathway	KEGG_MEDICUS_REFERENCE_NOTCH_PROTEOLYTIC_ACTIVATION	APH1B PSENEN	4.04e-04	11	39	2	M47865
Pathway	REACTOME_NUCLEAR_SIGNALING_BY_ERBB4	APH1B PSENEN	4.04e-04	11	39	2	MM14534
Pathway	REACTOME_REGULATED_PROTEOLYSIS_OF_P75NTR	APH1B PSENEN	4.04e-04	11	39	2	M2661
Pathway	REACTOME_NRIF_SIGNALS_CELL_DEATH_FROM_THE_NUCLEUS	APH1B PSENEN	6.65e-04	14	39	2	MM14826
Pathway	REACTOME_DEATH_RECEPTOR_SIGNALING	APH1B TIAM1 PSENEN TIAM2	8.37e-04	154	39	4	M27697
Pathway	KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION	AGTR1 GRIA2 GRM2 SSTR3 F2	8.68e-04	272	39	5	M13380
Pathway	REACTOME_NRIF_SIGNALS_CELL_DEATH_FROM_THE_NUCLEUS	APH1B PSENEN	8.73e-04	16	39	2	M7257
Pathway	REACTOME_CELL_DEATH_SIGNALLING_VIA_NRAGE_NRIF_AND_NADE	APH1B PSENEN TIAM2	9.43e-04	70	39	3	MM14824
Pathway	PID_SYNDECAN_3_PATHWAY	APH1B PSENEN	9.88e-04	17	39	2	M251
Pathway	KEGG_RENIN_ANGIOTENSIN_SYSTEM	AGTR1 MME	9.88e-04	17	39	2	M17636
Pathway	REACTOME_GPCR_LIGAND_BINDING	QRFP AGTR1 PENK GRM2 SSTR3 F2	1.08e-03	430	39	6	MM15160
Pathway	REACTOME_SIGNALING_BY_NOTCH3	APH1B PSENEN	1.24e-03	19	39	2	MM15594
Pathway	REACTOME_SIGNALING_BY_TGFBR3	APH1B PSENEN	1.52e-03	21	39	2	MM17231
Pathway	REACTOME_GPCR_LIGAND_BINDING	QRFP AGTR1 PENK GRM2 SSTR3 F2	1.58e-03	463	39	6	M507
Pathway	REACTOME_P75_NTR_RECEPTOR_MEDIATED_SIGNALLING	APH1B PSENEN TIAM2	1.65e-03	85	39	3	MM14746
Pathway	REACTOME_NOTCH2_ACTIVATION_AND_TRANSMISSION_OF_SIGNAL_TO_THE_NUCLEUS	APH1B PSENEN	1.66e-03	22	39	2	M27210
Pathway	REACTOME_CLASS_A_1_RHODOPSIN_LIKE_RECEPTORS	QRFP AGTR1 PENK SSTR3 F2	2.04e-03	330	39	5	M18334
Pathway	REACTOME_EPH_EPHRIN_SIGNALING	APH1B TIAM1 PSENEN	2.07e-03	92	39	3	M27201
Pathway	REACTOME_CLASS_A_1_RHODOPSIN_LIKE_RECEPTORS	QRFP AGTR1 PENK SSTR3 F2	2.13e-03	333	39	5	MM14963
Pathway	REACTOME_NOTCH3_ACTIVATION_AND_TRANSMISSION_OF_SIGNAL_TO_THE_NUCLEUS	APH1B PSENEN	2.15e-03	25	39	2	M27879
Pathway	REACTOME_G_ALPHA_Q_SIGNALLING_EVENTS	QRFP AGTR1 F2 RGS2	2.62e-03	210	39	4	MM15043
Pathway	REACTOME_G_ALPHA_Q_SIGNALLING_EVENTS	QRFP AGTR1 F2 RGS2	2.95e-03	217	39	4	M18437
Pubmed	RNA editing at a limited number of sites is sufficient to prevent MDA5 activation in the mouse brain.	IFIT1B GRIA2 IFIT1	1.16e-07	7	53	3	33983932
Pubmed	Ten years on: mediation of cell death by the common neurotrophin receptor p75(NTR).	APH1B TIAM1 PSENEN TIAM2	2.20e-06	60	53	4	12787561
Pubmed	2'-O methylation of the viral mRNA cap by West Nile virus evades ifit1-dependent and -independent mechanisms of host restriction in vivo.	IFIT1B IFIT1	2.28e-06	2	53	2	22589727
Pubmed	Mouse Ifit1b is a cap1-RNA-binding protein that inhibits mouse coronavirus translation and is regulated by complexing with Ifit1c.	IFIT1B IFIT1	2.28e-06	2	53	2	33454014
Pubmed	Cardiometabolic Consequences of Deleting the Regulator of G protein Signaling-2 (Rgs2) From Cells Expressing Agouti-Related Peptide or the ANG (Angiotensin) II Type 1A Receptor in Mice.	AGTR1 RGS2	2.28e-06	2	53	2	36259376
Pubmed	Overexpression of IFIT1 protects against LPS-induced acute lung injury via regulating CCL5-p65NF-κB signaling.	IFIT1B IFIT1	2.28e-06	2	53	2	36446235
Pubmed	Identification and validation of Ifit1 as an important innate immune bottleneck.	IFIT1B IFIT1	2.28e-06	2	53	2	22745654
Pubmed	Ifit1 inhibits Japanese encephalitis virus replication through binding to 5' capped 2'-O unmethylated RNA.	IFIT1B IFIT1	2.28e-06	2	53	2	23824812
Pubmed	The association between expression of IFIT1 in podocytes of MRL/lpr mice and the renal pathological changes it causes: An animal study.	IFIT1B IFIT1	2.28e-06	2	53	2	27823966
Pubmed	A viral RNA structural element alters host recognition of nonself RNA.	IFIT1B IFIT1	2.28e-06	2	53	2	24482115
Pubmed	Characterization of STEF, a guanine nucleotide exchange factor for Rac1, required for neurite growth.	TIAM1 TIAM2	2.28e-06	2	53	2	11707441
Pubmed	Sequestration by IFIT1 impairs translation of 2'O-unmethylated capped RNA.	IFIT1B IFIT1	2.28e-06	2	53	2	24098121
Pubmed	Evolution-guided functional analyses reveal diverse antiviral specificities encoded by IFIT1 genes in mammals.	IFIT1B IFIT1	2.28e-06	2	53	2	27240734
Pubmed	Roles of STEF/Tiam1, guanine nucleotide exchange factors for Rac1, in regulation of growth cone morphology.	TIAM1 TIAM2	2.28e-06	2	53	2	14550769
Pubmed	IFIT1 Differentially Interferes with Translation and Replication of Alphavirus Genomes and Promotes Induction of Type I Interferon.	IFIT1B IFIT1	2.28e-06	2	53	2	25927359
Pubmed	IFIT1 Exerts Opposing Regulatory Effects on the Inflammatory and Interferon Gene Programs in LPS-Activated Human Macrophages.	IFIT1B IFIT1	2.28e-06	2	53	2	30282041
Pubmed	Human and Murine IFIT1 Proteins Do Not Restrict Infection of Negative-Sense RNA Viruses of the Orthomyxoviridae, Bunyaviridae, and Filoviridae Families.	IFIT1B IFIT1	2.28e-06	2	53	2	26157117
Pubmed	Ifit1 Protects Against Lipopolysaccharide and D-galactosamine-Induced Fatal Hepatitis by Inhibiting Activation of the JNK Pathway.	IFIT1B IFIT1	2.28e-06	2	53	2	26459629
Pubmed	Crystallographic characterization of the membrane-targeting domains of the Rac-specific guanine nucleotide-exchange factors Tiam1 and Tiam2.	TIAM1 TIAM2	2.28e-06	2	53	2	18997336
Pubmed	MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.	MEST SLC25A12 SUPT5H RPF2 MRPS23 SMARCA4 TSPYL5 MYO1B TNXB ZBED5	4.71e-06	1082	53	10	38697112
Pubmed	Structure, chromosome localization, and regulation of expression of the interferon-regulated mouse Ifi54/Ifi56 gene family.	IFIT1B IFIT1	6.83e-06	3	53	2	7896268
Pubmed	aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation.	APH1B PSENEN	6.83e-06	3	53	2	12110170
Pubmed	The Interferon-Induced Exonuclease ISG20 Exerts Antiviral Activity through Upregulation of Type I Interferon Response Proteins.	IFIT1B IFIT1	6.83e-06	3	53	2	30232164
Pubmed	Mouse p56 blocks a distinct function of eukaryotic initiation factor 3 in translation initiation.	IFIT1B IFIT1	6.83e-06	3	53	2	15561726
Pubmed	Novel characteristics of the function and induction of murine p56 family proteins.	IFIT1B IFIT1	6.83e-06	3	53	2	18768971
Pubmed	Interferon-induced protein with tetratricopeptide repeats 1 (IFIT1) accelerates osteoclast formation by regulating signal transducer and activator of transcription 3 (STAT3) signalling.	IFIT1B IFIT1	6.83e-06	3	53	2	35034537
Pubmed	The interaction between interferon-induced protein with tetratricopeptide repeats-1 and eukaryotic elongation factor-1A.	IFIT1B IFIT1	6.83e-06	3	53	2	19856081
Pubmed	Identification of a serotonin/glutamate receptor complex implicated in psychosis.	GRIA2 GRM2	6.83e-06	3	53	2	18297054
Pubmed	Association between 3'UTR polymorphisms in genes ACVR2A, AGTR1 and RGS2 and preeclampsia.	AGTR1 RGS2	6.83e-06	3	53	2	29593124
Pubmed	Reconstitution of gamma-secretase by truncated presenilin (PS) fragments revealed that PS C-terminal transmembrane domain is critical for formation of gamma-secretase complex.	APH1B PSENEN	1.36e-05	4	53	2	16371134
Pubmed	Interferon-induced protein Ifit2 protects mice from infection of the peripheral nervous system by vesicular stomatitis virus.	IFIT1B IFIT1	1.36e-05	4	53	2	24991014
Pubmed	Ifit2 deficiency results in uncontrolled neurotropic coronavirus replication and enhanced encephalitis via impaired alpha/beta interferon induction in macrophages.	IFIT1B IFIT1	1.36e-05	4	53	2	24198415
Pubmed	The in vivo roles of STEF/Tiam1, Rac1 and JNK in cortical neuronal migration.	TIAM1 TIAM2	1.36e-05	4	53	2	12912917
Pubmed	Attenuation and restoration of severe acute respiratory syndrome coronavirus mutant lacking 2'-o-methyltransferase activity.	IFIT1B IFIT1	1.36e-05	4	53	2	24478444
Pubmed	Coordinated regulation and widespread cellular expression of interferon-stimulated genes (ISG) ISG-49, ISG-54, and ISG-56 in the central nervous system after infection with distinct viruses.	IFIT1B IFIT1	1.36e-05	4	53	2	17079283
Pubmed	Interferon-induced Ifit proteins: their role in viral pathogenesis.	IFIT1B IFIT1	1.36e-05	4	53	2	25428874
Pubmed	Interactions between angiotensin ll and atrial natriuretic peptide in renomedullary interstitial cells: the role of neutral endopeptidase.	AGTR1 MME	1.36e-05	4	53	2	16582578
Pubmed	The glucocorticoid attenuated response genes GARG-16, GARG-39, and GARG-49/IRG2 encode inducible proteins containing multiple tetratricopeptide repeat domains.	IFIT1B IFIT1	1.36e-05	4	53	2	8660659
Pubmed	Tissue-specific and inducer-specific differential induction of ISG56 and ISG54 in mice.	IFIT1B IFIT1	1.36e-05	4	53	2	17553874
Pubmed	Anxiolytic-like activity of the mGLU2/3 receptor agonist LY354740 in the elevated plus maze test is disrupted in metabotropic glutamate receptor 2 and 3 knock-out mice.	GRIA2 GRM2	1.36e-05	4	53	2	15619115
Pubmed	Sendai virus pathogenesis in mice is prevented by Ifit2 and exacerbated by interferon.	IFIT1B IFIT1	1.36e-05	4	53	2	25231314
Pubmed	Lysyl oxidase-like 2 promotes stemness and enhances antitumor effects of gefitinib in head and neck cancer via IFIT1 and IFIT3.	IFIT1B IFIT1	1.36e-05	4	53	2	37496288
Pubmed	Effects of mGlu2 or mGlu3 receptor deletions on mGlu2/3 receptor agonist (LY354740)-induced brain c-Fos expression: specific roles for mGlu2 in the amygdala and subcortical nuclei, and mGlu3 in the hippocampus.	GRIA2 GRM2	1.36e-05	4	53	2	16733060
Pubmed	The PHCCEx domain of Tiam1/2 is a novel protein- and membrane-binding module.	TIAM1 TIAM2	1.36e-05	4	53	2	19893486
Pubmed	Use of MGLUR2 and MGLUR3 knockout mice to explore in vivo receptor specificity of the MGLUR2/3 selective antagonist LY341495.	GRIA2 GRM2	1.36e-05	4	53	2	19477188
Pubmed	The protective role of Toll-like receptor 3 and type-I interferons in the pathophysiology of vein graft disease.	IFIT1B IFIT1	2.27e-05	5	53	2	29879406
Pubmed	Interferon Regulatory Factor 8 (IRF8) Impairs Induction of Interferon Induced with Tetratricopeptide Repeat Motif (IFIT) Gene Family Members.	IFIT1B IFIT1	2.27e-05	5	53	2	27137933
Pubmed	A small modulatory dsRNA specifies the fate of adult neural stem cells.	SMARCA4 GRM2	2.27e-05	5	53	2	15035981
Pubmed	Gamma-secretase is a membrane protein complex comprised of presenilin, nicastrin, Aph-1, and Pen-2.	APH1B PSENEN	2.27e-05	5	53	2	12740439
Pubmed	Ifit2 Is a Restriction Factor in Rabies Virus Pathogenicity.	IFIT1B IFIT1	2.27e-05	5	53	2	28637751
Pubmed	Interferon-induced Ifit2/ISG54 protects mice from lethal VSV neuropathogenesis.	IFIT1B IFIT1	2.27e-05	5	53	2	22615570
Pubmed	Control of cardiac jelly dynamics by NOTCH1 and NRG1 defines the building plan for trabeculation.	MEST ADAMTS4 SMARCA4	2.71e-05	38	53	3	29743679
Pubmed	Endocardial Brg1 represses ADAMTS1 to maintain the microenvironment for myocardial morphogenesis.	MEST ADAMTS4 SMARCA4	2.71e-05	38	53	3	18267097
Pubmed	Coordinated and widespread expression of gamma-secretase in vivo: evidence for size and molecular heterogeneity.	APH1B PSENEN	3.40e-05	6	53	2	15474363
Pubmed	Characterization of presenilin complexes from mouse and human brain using Blue Native gel electrophoresis reveals high expression in embryonic brain and minimal change in complex mobility with pathogenic presenilin mutations.	APH1B PSENEN	3.40e-05	6	53	2	14717705
Pubmed	APH1, PEN2, and Nicastrin increase Abeta levels and gamma-secretase activity.	APH1B PSENEN	3.40e-05	6	53	2	12763021
Pubmed	Development of IFN-Stimulated Gene Expression from Embryogenesis through Adulthood, with and without Constitutive MDA5 Pathway Activation.	IFIT1B IFIT1	3.40e-05	6	53	2	32277054
Pubmed	The broad-spectrum antiviral functions of IFIT and IFITM proteins.	IFIT1B IFIT1	3.40e-05	6	53	2	23237964
Pubmed	Cloning and chromosomal location of human genes inducible by type I interferon.	IFIT1B IFIT1	3.40e-05	6	53	2	3175763
Pubmed	Transcriptional landscape of pulmonary lymphatic endothelial cells during fetal gestation.	IFIT1B IFIT1	4.76e-05	7	53	2	31083674
Pubmed	2'-O methylation of the viral mRNA cap evades host restriction by IFIT family members.	IFIT1B IFIT1	4.76e-05	7	53	2	21085181
Pubmed	A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain.	APH1B PSENEN	6.34e-05	8	53	2	10206645
Pubmed	Preimplantation mouse embryo is a target for opioid ligand-receptor signaling.	PENK MME	6.34e-05	8	53	2	24855103
Pubmed	Purification and characterization of the human gamma-secretase complex.	APH1B PSENEN	6.34e-05	8	53	2	15274632
Pubmed	Systems analysis of RhoGEF and RhoGAP regulatory proteins reveals spatially organized RAC1 signalling from integrin adhesions.	TANC2 SLC25A12 TIAM1 DOCK11 PLEKHG7 MRPS23 SMARCA4 TIAM2	6.97e-05	916	53	8	32203420
Pubmed	The mitochondrial transporter family SLC25: identification, properties and physiopathology.	SLC25A12 SLC25A2 SLC25A16	7.42e-05	53	53	3	23266187
Pubmed	Prosaposin facilitates sortilin-independent lysosomal trafficking of progranulin.	IFIT1B MYO1B F2 IFIT1	8.05e-05	149	53	4	26370502
Pubmed	Irf8-regulated genomic responses drive pathological inflammation during cerebral malaria.	IFIT1B IFIT1	8.15e-05	9	53	2	23853600
Pubmed	APOC3, CETP, fibrinogen, and MTHFR are genetic determinants of carotid intima-media thickness in healthy men (the Stanislas cohort).	AGTR1 F2	8.15e-05	9	53	2	11359462
Pubmed	An essential role for Cmtr2 in mammalian embryonic development.	IFIT1B IFIT1	8.15e-05	9	53	2	39094818
Pubmed	Two RNase H2 Mutants with Differential rNMP Processing Activity Reveal a Threshold of Ribonucleotide Tolerance for Embryonic Development.	IFIT1B IFIT1	8.15e-05	9	53	2	30380406
Pubmed	Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment.	AGTR1 PENK GRIA2 GRM2 SSTR3	9.44e-05	300	53	5	19086053
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	TANC2 SGIP1 DOCK11 ATF7IP SMARCA4 GRIA2 GRM2 TENM2	9.86e-05	963	53	8	28671696
Pubmed	Antiviral Protection via RdRP-Mediated Stable Activation of Innate Immunity.	IFIT1B IFIT1	1.02e-04	10	53	2	26633895
Pubmed	ARID1a-DNA interactions are required for promoter occupancy by SWI/SNF.	MEST SMARCA4	1.02e-04	10	53	2	23129809
Pubmed	PTEN is essential for cell migration but not for fate determination and tumourigenesis in the cerebellum.	GRIA2 GRM2	1.02e-04	10	53	2	12091320
Pubmed	Proteolytic processing of the p75 neurotrophin receptor and two homologs generates C-terminal fragments with signaling capability.	APH1B PSENEN	1.02e-04	10	53	2	12843241
Pubmed	A protein-RNA interaction atlas of the ribosome biogenesis factor AATF.	RPF2 MRPS23 MYO1B NOL10	1.11e-04	162	53	4	31363146
Pubmed	Targeting HIV transcription: the quest for a functional cure.	SUPT5H SMARCA4	1.24e-04	11	53	2	25731772
Pubmed	Metalloproteases and gamma-secretase: new membrane partners regulating p75 neurotrophin receptor signaling?	APH1B PSENEN	1.24e-04	11	53	2	17986144
Pubmed	Genetic risk factors in typical haemolytic uraemic syndrome.	AGTR1 F2	1.49e-04	12	53	2	19110485
Pubmed	Protein recoding by ADAR1-mediated RNA editing is not essential for normal development and homeostasis.	IFIT1B IFIT1	1.49e-04	12	53	2	28874170
Pubmed	The PDZ proteins PICK1, GRIP, and syntenin bind multiple glutamate receptor subtypes. Analysis of PDZ binding motifs.	GRIA2 GRM2	1.49e-04	12	53	2	11891216
Pubmed	Abeta-degrading endopeptidase, neprilysin, in mouse brain: synaptic and axonal localization inversely correlating with Abeta pathology.	MME GRM2	1.49e-04	12	53	2	12074840
Pubmed	Association study of 182 candidate genes in anorexia nervosa.	GRIA2 FEV MME RGS2	1.74e-04	182	53	4	20468064
Pubmed	Postnatal gene expression in the normal mouse cornea by SAGE.	IFIT1B IFIT1	2.05e-04	14	53	2	14744882
Pubmed	Glucocorticoid-attenuated response genes encode intercellular mediators, including a new C-X-C chemokine.	IFIT1B IFIT1	2.05e-04	14	53	2	7622488
Pubmed	Ligand-dependent cleavage of the P75 neurotrophin receptor is necessary for NRIF nuclear translocation and apoptosis in sympathetic neurons.	APH1B PSENEN	2.05e-04	14	53	2	16630834
Pubmed	Tlx1 and Tlx3 coordinate specification of dorsal horn pain-modulatory peptidergic neurons.	PENK GRIA2	2.36e-04	15	53	2	18400903
Pubmed	Candidate gene polymorphisms in cardiovascular disease: a comparative study of frequencies between a French and an Italian population.	AGTR1 F2	2.36e-04	15	53	2	11341749
Pubmed	Host-cell sensors for Plasmodium activate innate immunity against liver-stage infection.	IFIT1B IFIT1	2.36e-04	15	53	2	24362933
Pubmed	Association of dysfunctional synapse defective 1 (SYDE1) with restricted fetal growth - SYDE1 regulates placental cell migration and invasion.	AGTR1 MME	2.36e-04	15	53	2	27917469
Pubmed	Usefulness of genetic polymorphisms and conventional risk factors to predict coronary heart disease in patients with familial hypercholesterolemia.	AGTR1 F2	2.36e-04	15	53	2	19166692
Pubmed	Tlx1/3 and Ptf1a control the expression of distinct sets of transmitter and peptide receptor genes in the developing dorsal spinal cord.	GRIA2 GRM2 SSTR3	2.62e-04	81	53	3	22723691
Pubmed	Causal relationship of susceptibility genes to ischemic stroke: comparison to ischemic heart disease and biochemical determinants.	AGTR1 F2	2.70e-04	16	53	2	20161734
Pubmed	p75NTR--live or let die.	APH1B PSENEN	2.70e-04	16	53	2	15721744
Pubmed	A novel tandem affinity purification strategy for the efficient isolation and characterisation of native protein complexes.	PHKB TIAM1 MAST3	3.24e-04	87	53	3	17979178
Pubmed	PTENα and PTENβ promote carcinogenesis through WDR5 and H3K4 trimethylation.	GTF3C2 MRPS23 SMARCA4 ANAPC7	3.40e-04	217	53	4	31685992
Pubmed	The macrophage IRF8/IRF1 regulome is required for protection against infections and is associated with chronic inflammation.	IFIT1B IFIT1	3.43e-04	18	53	2	27001747
Pubmed	A conserved acetylation switch enables pharmacological control of tubby-like protein stability.	GTF3C2 MRPS23 ANAPC7 MAST3	3.77e-04	223	53	4	33187986
Cytoband	1q21-q23	ADAMTS4 INSRR	1.01e-04	13	53	2	1q21-q23
Cytoband	10q23.31	IFIT1B IFIT1	7.16e-04	34	53	2	10q23.31
Cytoband	Ensembl 112 genes in cytogenetic band chr10q23	CYP26A1 IFIT1B IFIT1	1.51e-03	195	53	3	chr10q23
GeneFamily	Tetratricopeptide repeat domain containing\|Bardet-Biedl syndrome associated\|BBSome	TANC2 IFIT1B IFIT1 ANAPC7	1.19e-04	115	40	4	769
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	TIAM1 DOCK11 PLEKHG7 TIAM2	1.09e-03	206	40	4	682
GeneFamily	Endogenous ligands	QRFP PENK F2 RGS2	1.82e-03	237	40	4	542
GeneFamily	PDZ domain containing	TIAM1 TIAM2 MAST3	4.58e-03	152	40	3	1220
GeneFamily	Fibronectin type III domain containing	ATF7IP INSRR TNXB	5.29e-03	160	40	3	555
GeneFamily	Ankyrin repeat domain containing\|FERM domain containing	MYO15A FRMD5	5.47e-03	50	40	2	1293
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	TIAM1 TIAM2	9.36e-03	66	40	2	722
CoexpressionAtlas	DevelopingLowerUrinaryTract_e14.5_ Genital tubercle F_emap-6706_top-relative-expression-ranked_1000	TANC2 SGIP1 CLCA1 GTF3C2 ATF7IP GRIA2 MYO1B NOL10 MME TENM2 TIAM2	6.48e-06	850	53	11	gudmap_developingLowerUrinaryTract_e14.5_ Genital tubercle F_1000
CoexpressionAtlas	DevelopingLowerUrinaryTract_e14.5_ Genital tubercle F_emap-6706_k-means-cluster#5_top-relative-expression-ranked_1000	TANC2 GTF3C2 ATF7IP GRIA2 MYO1B NOL10 MME TIAM2	2.27e-05	478	53	8	gudmap_developingLowerUrinaryTract_e14.5_ Genital tubercle F_1000_k5
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	TIAM1 DOCK11 CYP26A1 PENK PAM FRMD5	1.09e-07	192	53	6	dc40ef2341e5d6a6d479f140e023fe1bf687928d
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST-Inh_L3-5_SST_MAFB\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	TIAM1 DOCK11 CYP26A1 PENK PAM MME	1.12e-07	193	53	6	c7e9e6e4bf5e07c9cbdf1aa7c8828f4b2500e3ff
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Intercalated_Cell_Type_B\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	TIAM1 INSRR GRM2 F2 CSMD3	8.50e-07	146	53	5	ec1f793409d1a81c0f9323eb3c82ffe01dae0e44
ToppCell	tumor_Lung-Fibroblasts-Pericytes\|tumor_Lung / Location, Cell class and cell subclass	MEST SGIP1 ADAMTS4 AGTR1 MYO1B	2.58e-06	183	53	5	a03dd563af9b15cb1f5de5732a229405a9f82d84
ToppCell	LPS-antiTNF-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_2\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	MEST SGIP1 ADAMTS4 AGTR1 MYO1B	2.65e-06	184	53	5	689a8af81a79a4bb3123cfa01958c953eab5de98
ToppCell	COPD-Stromal-Pericyte\|COPD / Disease state, Lineage and Cell class	MEST SGIP1 ADAMTS4 AGTR1 MYO1B	2.65e-06	184	53	5	a56264a22dfc2d3672b20134ab7c3c7c23da5ae1
ToppCell	LPS_only-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_2\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	MEST SGIP1 ADAMTS4 AGTR1 MYO1B	2.65e-06	184	53	5	327ff3ac8d2fecdd5d242bdc34f0dfdb1c59a68b
ToppCell	Fetal_29-31_weeks-Mesenchymal-pericyte_cell-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	MEST SGIP1 PAM MYO1B DCLK2	2.72e-06	185	53	5	a7dba7db79275884b2a93d8a16f2e0c739e71370
ToppCell	COVID-19-Fibroblasts-Pericytes\|COVID-19 / group, cell type (main and fine annotations)	MEST SGIP1 ADAMTS4 AGTR1 MYO1B	2.72e-06	185	53	5	4905adaeeffd353e089578e5ea614437dbe794e6
ToppCell	COPD-Stromal-Pericyte\|World / Disease state, Lineage and Cell class	MEST SGIP1 ADAMTS4 AGTR1 MYO1B	2.80e-06	186	53	5	8adfd2d1fda4e8aecc95192ea627bf7ed5214b8d
ToppCell	facs-Pancreas-Endocrine-3m-Epithelial-pancreatic_A_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DOCK11 PAM GRIA2 MYO1B FEV	2.80e-06	186	53	5	4bb54043f944a979db91bde9a86dd66f498c7658
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L5_PVALB_CNTNAP3P2\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	TIAM1 DOCK11 PAM MYO1B FRMD5	2.80e-06	186	53	5	6379609b7ace80683f5754b16aa77f11b43766ae
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST-Inh_L4-6_SST_MTHFD2P6\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	TIAM1 DOCK11 CYP26A1 PAM FRMD5	3.18e-06	191	53	5	de54dab85db70f847de75b3b6d7667a0e13b9bfb
ToppCell	5'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-pericyte_cell-Pericytes\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	MEST SGIP1 ADAMTS4 AGTR1 MYO1B	3.43e-06	194	53	5	8f19e553f18c313c2a2ff9453884b9484b255d71
ToppCell	5'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-pericyte_cell\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	MEST SGIP1 ADAMTS4 AGTR1 MYO1B	3.43e-06	194	53	5	67fbb81b7d20cb63be27b2a2beea5b5689f8e08c
ToppCell	5'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-pericyte_cell-Pericytes-Pericytes_L.2.3.1.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	MEST SGIP1 ADAMTS4 AGTR1 MYO1B	3.43e-06	194	53	5	f95935153bd2c4c3c7b2b729da6f7e98b45fed79
ToppCell	IPF-Stromal-Pericyte\|World / Disease state, Lineage and Cell class	MEST SGIP1 ADAMTS4 AGTR1 MYO1B	3.43e-06	194	53	5	1a41da29d5adaf766a84eff0003b959e4523f7f1
ToppCell	COVID-19-lung-Pericytes/_Smooth_Muscle\|lung / Disease (COVID-19 only), tissue and cell type	MEST SGIP1 ADAMTS4 AGTR1 MYO1B	3.43e-06	194	53	5	5e1e0513a54ec4cf0b247ec85c9fbc68dfac1da3
ToppCell	IPF-Stromal-Pericyte\|IPF / Disease state, Lineage and Cell class	MEST SGIP1 ADAMTS4 AGTR1 MYO1B	3.61e-06	196	53	5	8b6ff47ce5291d223f5e639fc45cd9267f418256
ToppCell	3'-Pediatric_IBD-SmallIntestine-Mesenchymal-Pericytes-Pericyte\|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract	MEST SGIP1 ADAMTS4 AGTR1 MYO1B	3.70e-06	197	53	5	452be45f4aac8459dd860493171f5f715368d663
ToppCell	Parenchymal-10x3prime_v2-Stromal-Pericyte\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	MEST SGIP1 ADAMTS4 AGTR1 MYO1B	3.98e-06	200	53	5	d70bad979299615fcba707ba21296020918705e6
ToppCell	Tracheal-10x3prime_v2-Stromal-Pericyte-Muscle_pericyte_pulmonary\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	MEST SGIP1 ADAMTS4 AGTR1 MYO1B	3.98e-06	200	53	5	8158f4eaeff945a6788c8e732b7a1b0d78052a06
ToppCell	Biopsy_Other_PF-Mesenchymal-Smooth_Muscle_cells\|Biopsy_Other_PF / Sample group, Lineage and Cell type	MEST SGIP1 ADAMTS4 AGTR1 MYO1B	3.98e-06	200	53	5	55ac281901309e30978da1f7489386e54489721e
ToppCell	Parenchymal-10x3prime_v2-Stromal-Pericyte-Muscle_pericyte_pulmonary\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	MEST SGIP1 ADAMTS4 AGTR1 MYO1B	3.98e-06	200	53	5	38c21ec379005f688df33aea65237a063c476c2e
ToppCell	Tracheal-10x3prime_v2-Stromal-Pericyte\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	MEST SGIP1 ADAMTS4 AGTR1 MYO1B	3.98e-06	200	53	5	600d56257b1b0cda8ed2fd0db92c6551711f7d6d
ToppCell	Parenchymal-10x5prime-Stromal-Pericyte-Muscle_pericyte_pulmonary\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	MEST SGIP1 ADAMTS4 AGTR1 MYO1B	3.98e-06	200	53	5	f9bc22ff17bb1c751e6b05bca3f403836f33459a
ToppCell	Parenchymal-10x5prime-Stromal-Pericyte\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	MEST SGIP1 ADAMTS4 AGTR1 MYO1B	3.98e-06	200	53	5	0a7640db28c708003d5da2d19eb651f6fedfd710
ToppCell	Hippocampus-Neuronal-Excitatory-eN1(Slc17a7)-eN1_1-Fibcd1\|Hippocampus / BrainAtlas - Mouse McCarroll V32	CYP26A1 PENK TNXB MAST3	1.75e-05	130	53	4	c70fb77324916d220d842a575558a8245c276599
ToppCell	Hippocampus-Neuronal-Excitatory-eN1(Slc17a7)-eN1_1\|Hippocampus / BrainAtlas - Mouse McCarroll V32	CYP26A1 PENK TNXB MAST3	2.61e-05	144	53	4	e2a2f260f5ebaaef46248d199c407a15ce9d024a
ToppCell	frontal_cortex-Neuronal-glutamatergic_neuron-L5_IT-L5_IT_ALM_Cbln4_Fezf2\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	MYO1B GRM2 SSTR3 MAST3	3.94e-05	160	53	4	d8241404d775f9a709abdf17988f36293fcf4c58
ToppCell	droplet-Lung-nan-3m-Myeloid-Interstitial_Macrophage\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TANC2 MRC1 MYO15A F2	4.03e-05	161	53	4	f1d3287d9cb4e0eec99b3509f5dc4b87ae8c8cc9
ToppCell	droplet-Lung-nan-3m-Myeloid-lung_macrophage\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TANC2 MRC1 MYO15A F2	4.03e-05	161	53	4	110cc7122e3c9f105a11d811d77c8a8852b9de6c
ToppCell	PND10-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	MRC1 CLCA1 CYP26A1 GRIA2	4.34e-05	164	53	4	4cfc9f92e49f86d3639e018b35b6a60dc62f494a
ToppCell	PND10-Endothelial-Endothelial_lymphatic-Lymphatic_EC\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	MRC1 CLCA1 CYP26A1 GRIA2	4.34e-05	164	53	4	7a8e5ef52a8fd2877d59ef0696af8a7af90bbed6
ToppCell	PND10-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC-LEC_mature\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	MRC1 CLCA1 CYP26A1 GRIA2	4.34e-05	164	53	4	5e5bd81414ea2d64f73cdef19a0a78c17bec8c18
ToppCell	PND10-Endothelial-Endothelial_lymphatic\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	MRC1 CLCA1 CYP26A1 GRIA2	4.34e-05	164	53	4	f13b8d9b7f42193f333d9a77571a1dde6bbb48d8
ToppCell	5'-Adult-SmallIntestine-Epithelial-Tuft-related-Tuft\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TANC2 PLEKHG7 MYO1B DCLK2	4.76e-05	168	53	4	8072d0496b7b730c4601009eaa69ec5366d26d73
ToppCell	Control-Stromal-Pericyte\|World / Disease state, Lineage and Cell class	SGIP1 ADAMTS4 AGTR1 MYO1B	5.22e-05	172	53	4	813d4256b05b66ca11b08cc0026459d79f12c0eb
ToppCell	Adult-Mesenchymal-pericyte_cell-D231\|Adult / Lineage, Cell type, age group and donor	MEST SGIP1 AGTR1 MYO1B	5.22e-05	172	53	4	858cee96c1c06160863b4adcd7023c0d678bd50f
ToppCell	Control-Stromal-Pericyte\|Control / Disease state, Lineage and Cell class	SGIP1 ADAMTS4 AGTR1 MYO1B	5.46e-05	174	53	4	91fc1f1c891f105a91968c22e2de5321c52b439a
ToppCell	primary_visual_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Ptprt_Pkp2\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	TIAM1 DOCK11 PENK CSMD3	5.71e-05	176	53	4	05ec715439f2eb1696f5d8855da0dd1dd70effd0
ToppCell	3'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-pericyte_cell-Pericytes-Pericytes_L.2.3.1.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SGIP1 ADAMTS4 AGTR1 MYO1B	5.83e-05	177	53	4	452ec2df36c6d656a7cdadc55be545ccdb146a29
ToppCell	cellseq2-Mesenchymal-Myocytic-Myocytic_1-Pericyte\|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	MEST ADAMTS4 AGTR1 MYO1B	5.83e-05	177	53	4	68263456a3c93cd195b321b309ff59e156d732fe
ToppCell	cellseq2-Mesenchymal-Myocytic-Myocytic_1\|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	MEST ADAMTS4 AGTR1 MYO1B	5.83e-05	177	53	4	e415e448c37adc102d766235e9953dec32c021f1
ToppCell	Children_(3_yrs)-Mesenchymal-pericyte_cell-D046\|Children_(3_yrs) / Lineage, Cell type, age group and donor	MEST SGIP1 AGTR1 MYO1B	5.96e-05	178	53	4	185b44700f06ec58b3c09c80520502166c965fd6
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Intercalated_Cell_Type_B\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	TIAM1 INSRR DCLK2 CSMD3	5.96e-05	178	53	4	51d2188406f04329311b2efd1108fc36617a860e
ToppCell	droplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_D_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MEST TIAM1 GRIA2 CSMD3	6.09e-05	179	53	4	7c8a2fa1326c73dc9e774df645b572864fd97133
ToppCell	droplet-Bladder-nan-24m-Epithelial-nan\|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC25A2 PENK MME TNXB	6.09e-05	179	53	4	dfd9d29281510d32f1a2e8336d2e58ef496cfd1d
ToppCell	5'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-pericyte_cell-Pericytes-Pericytes_L.2.3.3.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	MEST SGIP1 ADAMTS4 AGTR1	6.09e-05	179	53	4	dc6cd46fa652b296ddbc41855f6377946d0a4cdc
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Intercalated_Cell_Type_B\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	TIAM1 INSRR DCLK2 CSMD3	6.23e-05	180	53	4	cfc8bfbfd3617aabbb49f9730c29b673ca157e74
ToppCell	droplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_D_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MEST TIAM1 GRIA2 CSMD3	6.23e-05	180	53	4	8bf6e8b6b45ce42f8c5f23e7cd1752ec8b3fa2d2
ToppCell	normal_Lung-Fibroblasts-Pericytes\|normal_Lung / Location, Cell class and cell subclass	MEST SGIP1 AGTR1 MYO1B	6.36e-05	181	53	4	f74941e49950027360d71ea3b205fc20c6929766
ToppCell	Control-Myeloid-Alveolar_macrophages\|Control / group, cell type (main and fine annotations)	MRC1 TIAM1 DOCK11 MME	6.36e-05	181	53	4	8d2102c8c86c59a82610f26f90946b290552e666
ToppCell	3'-Distal_airway-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophages-\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	MRC1 QRFP DOCK11 MME	6.36e-05	181	53	4	166ff44fcc0a2943b7f485ea8a9c314964e013bb
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_C_(IT_L4_RORB)-Exc_L2-4_RORB_GRIK1\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	PENK MYO1B TENM2 FRMD5	6.36e-05	181	53	4	57994ff4ecffb15653aee00644d9f887f5e3461d
ToppCell	COVID-19-kidney-CD-IC-B\|COVID-19 / Disease (COVID-19 only), tissue and cell type	TIAM1 INSRR DCLK2 CSMD3	6.50e-05	182	53	4	ee6a8c356bbbdae55e4ea858337e079491f9f4aa
ToppCell	LPS-IL1RA+antiTNF-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_2\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	MEST SGIP1 DOCK11 MYO1B	6.64e-05	183	53	4	8a799807fbf24456a9811e0c64068187940a2f71
ToppCell	3'-Broncho-tracheal-Mesenchymal-Fibroblastic-fibroblastic_type_1-Adventitial_fibroblasts-Adventitial_fibroblasts_L.2.1.0.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ADAMTS4 PENK FEV TNXB	6.78e-05	184	53	4	4a9f798c67b9998bffe44242b210cc1e224ff5b1
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SGIP1 ADAMTS4 AGTR1 MYO1B	6.92e-05	185	53	4	51dfe6ac7df8b330343b37e3bee71e5c65267189
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Podocyte\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SGIP1 MYO1B MME TENM2	6.92e-05	185	53	4	9197f074e769d54031ec41abfc65fcc0c6552c7e
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SGIP1 MYO1B MME TENM2	6.92e-05	185	53	4	ce7d62394b09c26ca65b8cdb280afec5e25bbb62
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SGIP1 ADAMTS4 AGTR1 MYO1B	6.92e-05	185	53	4	a8c02cec3c414f3a0da9f2d6d28ce563b0030705
ToppCell	human_hepatoblastoma-Hepatic_Stellate_cells\|World / Sample and Cell Type and Tumor Cluster (all cells)	SGIP1 ADAMTS4 PAM DCLK2	7.07e-05	186	53	4	cb1fc4b9140666b43415e21c9b434dc9b144e9d0
ToppCell	3'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-pericyte_cell-Pericytes-Pericytes_L.2.3.3.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	MEST SGIP1 AGTR1 MYO1B	7.07e-05	186	53	4	888e85a025bd982d36c910db0f5a3385b1ca3b28
ToppCell	COPD-Stromal-Pericyte\|Stromal / Disease state, Lineage and Cell class	SGIP1 ADAMTS4 AGTR1 MYO1B	7.22e-05	187	53	4	406ecd1dabb3ed8d871aef159f7bd1e383434953
ToppCell	COVID-19-kidney-CD-IC-B\|kidney / Disease (COVID-19 only), tissue and cell type	TIAM1 INSRR DCLK2 CSMD3	7.22e-05	187	53	4	ce05b89860573fe0356102e2998d1ef6d1968034
ToppCell	Children_(3_yrs)-Mesenchymal-pericyte_cell\|Children_(3_yrs) / Lineage, Cell type, age group and donor	MEST SGIP1 AGTR1 MYO1B	7.37e-05	188	53	4	ee151792c7ac9afe820f1a281c6dab383799f358
ToppCell	Macrophages-Cryobiopsy_01\|World / lung cells shred on cell class, cell subclass, sample id	MRC1 DOCK11 MME ITGA5	7.52e-05	189	53	4	c05b4b565c0ce56dbb45fc9503654a2ec1a7e1e9
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L2-4_PVALB_C8orf4\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	TIAM1 DOCK11 PAM MYO1B	7.52e-05	189	53	4	99a13b1b669b0cd36e3096632351d9ade25d1173
ToppCell	Mesenchymal-pericyte_cell\|World / Lineage, Cell type, age group and donor	MEST SGIP1 MYO1B DCLK2	7.52e-05	189	53	4	d7ed96add29f219183c802895fbff519b627f635
ToppCell	IPF-Myeloid-Macrophage_Alveolar\|IPF / Disease state, Lineage and Cell class	TANC2 MRC1 DOCK11 MME	7.68e-05	190	53	4	e539ebc0f4c5ee5dba86c614387be7d91338ad47
ToppCell	nucseq-Mesenchymal-Myocytic-Myocytic_1-Pericyte\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	SGIP1 ADAMTS4 AGTR1 MYO1B	7.68e-05	190	53	4	4eb92aef1ee868f4537483d19014d947b7684612
ToppCell	droplet-Lung-21m-Endothelial-lymphatic_endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	MRC1 CLCA1 GRIA2 MYO1B	7.68e-05	190	53	4	f50b9814a1beac67dc042a8c27dfd085ceeda3a6
ToppCell	droplet-Lung-21m-Endothelial-lymphatic_endothelial-lymphatic_endothelial_cell\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	MRC1 CLCA1 GRIA2 MYO1B	7.68e-05	190	53	4	a22a510b4a257eb0eaf09c7ae7978d3d2f07a58c
ToppCell	nucseq-Mesenchymal-Myocytic-Myocytic_1\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	SGIP1 ADAMTS4 AGTR1 MYO1B	7.68e-05	190	53	4	7be4341e2909101d756f14031c21e705eb45e69a
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_C_(IT_L4_RORB)\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	TADA1 PAM TENM2 FRMD5	7.68e-05	190	53	4	1bbbf0ce222e51f9fd2daca0c18d3965fd4efd31
ToppCell	droplet-Lung-21m-Endothelial-lymphatic_endothelial\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	MRC1 CLCA1 GRIA2 MYO1B	7.68e-05	190	53	4	57c136bf6d7feafb4a220877bed0cc8fdf314db2
ToppCell	Brain_organoid-organoid_Paulsen_bioRxiv-3.5_mon-Neuronal-Immature_INs\|3.5_mon / Sample Type, Dataset, Time_group, and Cell type.	MEST MYO1B DCLK2 TIAM2	7.68e-05	190	53	4	842760bfe0a52e67bad800efa7d99448a4a23ebb
ToppCell	droplet-Pancreas-Endocrine-18m-Epithelial\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	INSRR PAM SSTR3 RGS2	7.83e-05	191	53	4	fd01a206763dfb6d52cca67123571936b4a8e1a0
ToppCell	PSB-critical-LOC-Epithelial-Ionocyte\|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	CYP26A1 FOXI2 GRIA2 DCLK2	7.83e-05	191	53	4	8f4637e801554e2343b974fe7794f01dd2151418
ToppCell	Control-Myeloid\|Control / group, cell type (main and fine annotations)	MRC1 TIAM1 DOCK11 MME	7.83e-05	191	53	4	9c4acc5f3c2f9c0c5520863bb22f391774372347
ToppCell	ILEUM-non-inflamed-(6)_ILC3\|non-inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	SGIP1 TIAM1 CYP26A1 PENK	7.83e-05	191	53	4	6eaf72b41084404bee0db04e4605db745a74995f
ToppCell	3'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-pericyte_cell\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	MEST SGIP1 AGTR1 MYO1B	7.83e-05	191	53	4	1626b23a57429f835fddc052e3c57f63a4e5b8bb
ToppCell	5'-Adult-LargeIntestine-Epithelial-Tuft-related-Tuft\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TANC2 PLEKHG7 MYO1B DCLK2	7.83e-05	191	53	4	54f07e4de61735051498846afb44b1798bed8144
ToppCell	3'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-pericyte_cell-Pericytes\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	MEST SGIP1 AGTR1 MYO1B	7.83e-05	191	53	4	716dfa7fccbd62b5f574792e68a26dc6c45511dc
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SGIP1 AGTR1 MYO1B DCLK2	7.83e-05	191	53	4	7b0d42a877540dbb346a76a62403e0d5d3e07fa6
ToppCell	COVID-19-lung-Macrophage_PPARGhi_CD5Lhi\|lung / Disease (COVID-19 only), tissue and cell type	MRC1 TIAM1 DOCK11 MME	7.83e-05	191	53	4	dab953682b8c9ed680a799161f837f792a7e4f33
ToppCell	facs-Pancreas-Endocrine-3m-Epithelial\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PAM GRIA2 SSTR3 RGS2	7.83e-05	191	53	4	657297cd19d05a7e7bb74fc3a086fbd95f47aae4
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SGIP1 AGTR1 MYO1B DCLK2	7.83e-05	191	53	4	cd854b9c426924fdc84bf7f411f6dea447143e79
ToppCell	droplet-Pancreas-Endocrine-18m\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	INSRR PAM SSTR3 RGS2	7.99e-05	192	53	4	4510aa262da8dcf7c944b3907a51aba5a9397a4e
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	TIAM1 DOCK11 CYP26A1 PAM	8.15e-05	193	53	4	010717ca052b6c8a525a43aaeffddea0d1113e63
ToppCell	3'-Distal_airway-Mesenchymal-Mesenchymal_Myocytic-pericyte_cell-Pericytes\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	MEST SGIP1 AGTR1 MYO1B	8.15e-05	193	53	4	b2abe939027a69b60d83a28d4d4cc53ba1dee4c5
ToppCell	3'-Distal_airway-Mesenchymal-Mesenchymal_Myocytic\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	MEST SGIP1 AGTR1 MYO1B	8.15e-05	193	53	4	87ce81ff5b27d9c4300826d76ff5a62e9c408d5d
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	TIAM1 DOCK11 CYP26A1 PAM	8.15e-05	193	53	4	2189da4b727e25e62669d7b9257f06493be21a27
ToppCell	3'-Distal_airway-Mesenchymal-Mesenchymal_Myocytic-pericyte_cell\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	MEST SGIP1 AGTR1 MYO1B	8.15e-05	193	53	4	d75f334fe3d9f39ef02a5de0f8202f7a761a8fc8
ToppCell	facs-Liver-Liver_non-hepato/SCs-18m-Endothelial-nan\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MRC1 ADAMTS4 PAM TNXB	8.15e-05	193	53	4	2483bb7f398e4fa0ef09c8bd584ed25703853f03
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_3\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	TIAM1 DOCK11 PAM FRMD5	8.15e-05	193	53	4	53bcd50892c379b2a571751f6eb1062436339fe7
ToppCell	3'-Distal_airway-Mesenchymal-Mesenchymal_Myocytic-pericyte_cell-Pericytes-Pericytes_L.2.3.1.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	MEST SGIP1 AGTR1 MYO1B	8.15e-05	193	53	4	41ea268e7697101fe70d8ef1045f3a43b9311739
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_3\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	TIAM1 DOCK11 PAM FRMD5	8.15e-05	193	53	4	5581a5ebcd21a2a8062ccfb917f088ec67a10a9c
ToppCell	droplet-Liver-LIVER-NPC-1m-Mesenchymal-hepatic_stellate_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MEST CLCA1 PAM TNXB	8.32e-05	194	53	4	415801a3dfacf05f2b603fb424df3d045190a812
Computational	Adrenal gland - metabolic genes.	MRC1 AGTR1 PENK FEV IFIT1 TNXB RGS2	9.83e-05	314	38	7	MODULE_19
Drug	Propioxatin A	PENK MME	5.32e-06	2	53	2	CID000128218
Drug	Phelorphan	PENK MME	5.32e-06	2	53	2	CID000187071
Drug	Ici 154129	PSENEN PENK MME	6.53e-06	16	53	3	CID003035055
Drug	boroleucine	PENK MME	1.59e-05	3	53	2	CID000127495
Drug	carbaphethiol	PENK MME	1.59e-05	3	53	2	CID003037579
Drug	125I]iodo-	AGTR1 PENK MME	1.78e-05	22	53	3	CID000644290
Drug	Rges Peptide	PAM ITGA5 F2	2.04e-05	23	53	3	CID000121927
Drug	Deltakephalin	PSENEN PENK MME	2.33e-05	24	53	3	CID000119319
Drug	prochloraz	APH1B PSENEN DCLK2 MME F2	3.02e-05	155	53	5	CID000073665
Drug	phethiol	PENK MME	3.18e-05	4	53	2	CID000136802
Drug	KPLP	PENK MME	3.18e-05	4	53	2	CID000133544
Drug	Cocaine	MRC1 SUPT5H CYP26A1 PENK GRIA2 FEV MME GRM2 TENM2 RGS2 FRMD5 TIAM2	3.81e-05	1314	53	12	ctd:D003042
Drug	Kelatorphan	PSENEN PENK MME	4.63e-05	30	53	3	CID000123982
Drug	Tyr-gly-gly-phe	PENK PAM MME	4.63e-05	30	53	3	CID006453937
Drug	Daeam	PENK MME	5.29e-05	5	53	2	CID009570639
Drug	Pencina	PENK MME	5.29e-05	5	53	2	CID000030729
Drug	GW8510; Down 200; 10uM; PC3; HT_HG-U133A	ATF7IP TSPYL5 IFIT1 RGS2 ZBED5	6.50e-05	182	53	5	7085_DN
Drug	EIPA	AGTR1 PAM SLC25A16 F2	7.12e-05	95	53	4	CID000001795
Drug	DSLET	PSENEN PENK MME	7.40e-05	35	53	3	CID000107847
Drug	haloperidol; Up 200; 10uM; MCF7; HT_HG-U133A_EA	APH1B PHKB PAM ITGA5 IFIT1	9.22e-05	196	53	5	1041_UP
Drug	Propafenone hydrochloride [34183-22-7]; Up 200; 10.6uM; MCF7; HT_HG-U133A	PENK MYO1B MME IFIT1 RGS2	9.22e-05	196	53	5	2871_UP
Drug	C070379	CLCA1 AGTR1 GRM2 F2 RGS2	9.90e-05	199	53	5	CID003034747
Drug	BAPTA	AGTR1 GRIA2 GRM2 SLC25A16 F2 RGS2	1.04e-04	324	53	6	CID000104751
Drug	Morphiceptin	PSENEN PENK SSTR3	1.11e-04	40	53	3	CID000119303
Drug	chromanone	PENK SSTR3	1.11e-04	7	53	2	CID000068110
Drug	RB 38A	PENK MME	1.11e-04	7	53	2	CID000129130
Drug	alpiropride	PENK MME	1.11e-04	7	53	2	CID000071253
Drug	AC1L1KMJ	TIAM1 PAM MYO1B ITGA5 MYO15A SLC25A16 F2	1.12e-04	476	53	7	CID000030956
Drug	L000369	PENK GRIA2 GRM2	1.19e-04	41	53	3	CID003931705
Drug	AC1NNRU4	PENK GRIA2 GRM2	1.19e-04	41	53	3	CID005126051
Drug	AC1L1I54	PSENEN PENK SSTR3	1.19e-04	41	53	3	CID000004426
Drug	AC1L1KS5	TIAM1 AGTR1 ITGA5 GRM2 F2 RGS2	1.22e-04	334	53	6	CID000005631
Drug	2,4-TDI	MEST FEV MME	1.28e-04	42	53	3	CID000011443
Drug	HCBP-Gly	PENK MME	1.48e-04	8	53	2	CID000124786
Drug	Dithionite	PAM GRIA2	1.48e-04	8	53	2	ctd:D004227
Drug	cFP-F-pAB	PENK MME	1.48e-04	8	53	2	CID000132283
Drug	Saapna	PENK MME	1.48e-04	8	53	2	CID005748178
Drug	aminopeptidase N inhibitor	PENK MME	1.48e-04	8	53	2	CID010067728
Drug	Epiamastatin hydrochloride	AGTR1 PENK MME SSTR3	1.49e-04	115	53	4	CID000003237
Drug	AC1L63MU	PSENEN AGTR1 GRIA2 MME GRM2 F2	1.51e-04	347	53	6	CID000285703
Drug	blebbistatin	MYO1B ITGA5 MYO15A SLC25A16	1.54e-04	116	53	4	CID003476986
Drug	Gly-D-Phe	PENK PAM MME	1.68e-04	46	53	3	CID000092953
Drug	ibotenic acid	CLCA1 PENK GRIA2 GRM2	1.88e-04	122	53	4	CID000001233
Drug	aspartate	CLCA1 SLC25A12 PSENEN SLC25A2 GRIA2 MME GRM2	1.89e-04	518	53	7	CID000000424
Drug	CHEMBL1783187	AGTR1 INSRR	1.89e-04	9	53	2	CID005230731
Drug	AC1MJ5M1	PENK MME	1.89e-04	9	53	2	CID003086119
Drug	N-carboxymethyl-Phe-Leu	PENK MME	1.89e-04	9	53	2	CID000004356
Drug	beta-Neurokinin	AGTR1 PENK MME	2.03e-04	49	53	3	CID000055583
Drug	AC1L1GTT	TIAM1 GRIA2 SLC25A16 F2 RGS2	2.07e-04	233	53	5	CID000003837
Drug	NSC265489	PSENEN AGTR1 PENK MME	2.19e-04	127	53	4	CID000003238
Drug	SB10	ITGA5 MYO15A	2.36e-04	10	53	2	CID000046019
Drug	NSC351912	PENK MME	2.36e-04	10	53	2	CID000100168
Drug	CAS 87333-19-5	AGTR1 MME F2	2.57e-04	53	53	3	CID000005038
Drug	PDBu	CLCA1 AGTR1 ITGA5 SLC25A16 F2	2.81e-04	249	53	5	CID000037783
Drug	Trimu-5	PENK MME	2.89e-04	11	53	2	CID005487273
Drug	Cfp-aaf-pab	PENK MME	2.89e-04	11	53	2	CID005748203
Drug	Rb 104	PENK MME	2.89e-04	11	53	2	CID000132708
Drug	N-acetylcystine	AGTR1 GRM2	2.89e-04	11	53	2	CID000065352
Disease	cataract 48 (implicated_via_orthology)	TIAM1 TIAM2	2.93e-06	2	51	2	DOID:0070354 (implicated_via_orthology)
Disease	heroin dependence (implicated_via_orthology)	PENK GRM2	1.75e-05	4	51	2	DOID:9976 (implicated_via_orthology)
Disease	brain disease (implicated_via_orthology)	TIAM1 TIAM2	4.37e-05	6	51	2	DOID:936 (implicated_via_orthology)
Disease	Tourette syndrome	TSPYL5 CSMD3 TENM2	9.00e-05	50	51	3	EFO_0004895
Disease	glomerulosclerosis (biomarker_via_orthology)	AGTR1 RGS2	1.31e-04	10	51	2	DOID:0050851 (biomarker_via_orthology)
Disease	Alzheimer disease	MRC1 APH1B MME MYO15A TENM2 TNXB	1.84e-04	485	51	6	MONDO_0004975
Disease	adenosine monophosphate measurement	MYO1B CSMD3	4.40e-04	18	51	2	EFO_0010454
Disease	coronary artery disease (is_implicated_in)	APH1B AGTR1 F2	6.99e-04	100	51	3	DOID:3393 (is_implicated_in)
Disease	serum gamma-glutamyl transferase measurement	SGIP1 DOCK11 CYP26A1 MYO1B CSMD3 TENM2 MAST3	9.44e-04	914	51	7	EFO_0004532
Disease	Drug habituation	CSMD3 TENM2 TIAM2	1.05e-03	115	51	3	C0013170
Disease	Substance-Related Disorders	CSMD3 TENM2 TIAM2	1.05e-03	115	51	3	C0236969
Disease	Drug abuse	CSMD3 TENM2 TIAM2	1.05e-03	115	51	3	C0013146
Disease	Drug Use Disorders	CSMD3 TENM2 TIAM2	1.05e-03	115	51	3	C0013222
Disease	Drug Dependence	CSMD3 TENM2 TIAM2	1.05e-03	115	51	3	C1510472
Disease	Substance Dependence	CSMD3 TENM2 TIAM2	1.05e-03	115	51	3	C0038580
Disease	Substance Use Disorders	CSMD3 TENM2 TIAM2	1.05e-03	115	51	3	C0038586
Disease	Organic Mental Disorders, Substance-Induced	CSMD3 TENM2 TIAM2	1.05e-03	115	51	3	C0029231
Disease	Prescription Drug Abuse	CSMD3 TENM2 TIAM2	1.05e-03	115	51	3	C4316881
Disease	Substance abuse problem	CSMD3 TENM2 TIAM2	1.07e-03	116	51	3	C0740858
Disease	sensorineural hearing loss (is_implicated_in)	MYO15A F2	1.49e-03	33	51	2	DOID:10003 (is_implicated_in)

Protein segments in the cluster

Peptide	Gene	Start	Entry
FRFAYYKLLKKASEG	APH1B	86	Q8WW43
NKKGFRIRYIAFYCS	CSMD3	2556	Q7Z407
ALIFAGFGFYLYKQR	CSMD3	3641	Q7Z407
FYGFLGKKFKRYFLQ	AGTR1	301	P30556
KVHGKRYAYRFDFQG	FEV	116	Q99581
FTYLRAGSGRYRYQK	GRM2	456	Q14416
FFASRKGYSRKGFDR	PAM	926	P19021
KTIYAKEGGFFGFYR	SLC25A16	176	P16260
YQKRYGGFLKRFAEA	PENK	226	P01210
FYSKRYSRALYLGAK	ANAPC7	316	Q9UJX3
AVREAAYKRFGYKLA	MYO15A	601	Q9UKN7
KYLLKFVSDYGRNGF	MYO15A	2166	Q9UKN7
FYRNGDRYFKGLVFA	DCLK2	76	Q8N568
YVAGNFPFYKRSKAG	FOXI2	131	Q6ZQN5
FSRGVYAIFGFYDKK	GRIA2	81	P42262
TYKESRNAFRKALYG	MME	386	P08473
GFYYKTRIPKFGRDF	NOL10	126	Q9BSC4
KLNLCRKYYLGGFAF	PSENEN	11	Q9NZ42
GYSRKKGGFSFRFGR	QRFP	121	P83859
YKLGFFKRSLPYGTA	ITGA5	1021	P08648
FFKGSRFRYSGRVAK	FRMD5	311	Q7Z6J6
SKQSGSFRKFRYGYN	ADAMTS4	686	O75173
KKRLLGTFFRVAFYG	DOCK11	1756	Q5JSL3
YAAKFYRRKGSVDKA	IFIT1B	256	Q5T764
GSKYYFAVRAKDIYG	ATF7IP	1236	Q6VMQ6
SGKKYGFSLRAIRVY	MAST3	956	O60307
TYVFRYAAKFYRRKG	IFIT1	251	P09914
YAAKFYRRKGSVDKA	IFIT1	256	P09914
GFFYGKKRNRTLYAS	INSRR	941	P14616
KRRKYGFIYKTHLFG	CYP26A1	71	O43174
SGKFFTYKGLRIFYQ	MEST	46	Q5EB52
GKYGFKRFLRDGYRT	PHKB	326	Q93100
TGAGLAAYFFYKKRR	MRC1	1401	P22897
RAKFYSVYGSGQRAF	MRPS23	71	Q9Y3D9
KYGLAAFRAFLKSEF	RGS2	91	P41220
ILYGFLSYRFKQGFR	SSTR3	311	P32745
AYRLRDGHFKYAFGS	TADA1	196	Q96BN2
FAYRGFKYLRLDGTT	SMARCA4	1116	P51532
RYQYALKKFPREGFG	TANC2	1266	Q9HCD6
FLGTGRQVFYKYGKL	TENM2	2011	Q9NT68
FEGNRYSRKGFLFKS	SUPT5H	361	O00267
FLKTYAQVGLRGFYK	SLC25A2	51	Q9BXI2
FTALNGKIYFRSYKL	RPF2	186	Q9H7B2
KAYLDFREKGGYRTT	CHAC2	76	Q8WUX2
FKKVLRYEGFFGLYR	SLC25A12	376	O75746
SLYLLEATGKRFYFK	CLCA1	61	A8K7I4
FKKVLFSLGGSFLYY	TIAM1	1121	Q13009
FSLGGSFLYYADRFK	TIAM1	1126	Q13009
RKLLFSLGGSFLYYA	TIAM2	1181	Q8IVF5
VGAGYRFSLIKKRFA	SGIP1	806	Q9BQI5
YKFVLYGFVGKKRHG	TNXB	1126	P22105
KRRKYDESYLSFGFT	ZBED5	106	Q49AG3
RDGKYGFYTHVFRLK	F2	596	P00734
VKITSFRGYDFYGLK	PLEKHG7	251	Q6ZR37
AGYLGFKAYFTAPRK	GTF3C2	691	Q8WUA4
GLARLGYKIKFYFDR	TSPYL5	286	Q86VY4
EYRKFFRANAGKKIY	MYO1B	856	O43795