Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	structural constituent of skin epidermis	KRT5 KRT74 KRT81 KRT82 KRT83 KRT86	4.30e-09	43	63	6	GO:0030280
GeneOntologyMolecularFunction	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity	ALDH2 ALDH9A1	3.48e-04	9	63	2	GO:0043878
GeneOntologyMolecularFunction	potassium:chloride symporter activity	SLC12A6 SLC12A5	3.48e-04	9	63	2	GO:0015379
GeneOntologyMolecularFunction	structural molecule activity	HSPG2 KRT5 KRT74 KRT81 KRT82 KRT83 KRT86 DMBT1 CSRP3 TUBAL3	4.43e-04	891	63	10	GO:0005198
GeneOntologyMolecularFunction	ammonium channel activity	SLC12A6 SLC12A5	6.34e-04	12	63	2	GO:0008519
GeneOntologyMolecularFunction	aldehyde dehydrogenase (NAD+) activity	ALDH2 ALDH9A1	1.00e-03	15	63	2	GO:0004029
GeneOntologyBiologicalProcess	intermediate filament organization	KRT5 KRT74 KRT81 KRT82 KRT83 KRT86	9.86e-08	75	62	6	GO:0045109
GeneOntologyBiologicalProcess	keratinization	KRT5 KRT74 KRT81 KRT82 KRT83 KRT86	2.41e-07	87	62	6	GO:0031424
GeneOntologyBiologicalProcess	intermediate filament cytoskeleton organization	KRT5 KRT74 KRT81 KRT82 KRT83 KRT86	5.19e-07	99	62	6	GO:0045104
GeneOntologyBiologicalProcess	intermediate filament-based process	KRT5 KRT74 KRT81 KRT82 KRT83 KRT86	5.51e-07	100	62	6	GO:0045103
GeneOntologyBiologicalProcess	keratinocyte differentiation	KRT5 KRT74 KRT81 KRT82 KRT83 KRT86	2.19e-05	189	62	6	GO:0030216
GeneOntologyBiologicalProcess	skin development	FOXE1 KRT5 KRT74 KRT81 KRT82 KRT83 KRT86	1.25e-04	373	62	7	GO:0043588
GeneOntologyBiologicalProcess	epidermal cell differentiation	KRT5 KRT74 KRT81 KRT82 KRT83 KRT86	2.08e-04	284	62	6	GO:0009913
GeneOntologyCellularComponent	intermediate filament	KRT5 KRTAP13-4 KRTAP13-2 KRT74 KRT81 KRT82 KRT83 KRTAP19-5 KRTAP19-7 KRT86 KRTAP7-1 KRTAP13-1	3.29e-12	227	63	12	GO:0005882
GeneOntologyCellularComponent	intermediate filament cytoskeleton	KRT5 KRTAP13-4 KRTAP13-2 KRT74 KRT81 KRT82 KRT83 KRTAP19-5 KRTAP19-7 KRT86 KRTAP7-1 KRTAP13-1	1.85e-11	263	63	12	GO:0045111
GeneOntologyCellularComponent	supramolecular fiber	KRT5 HDAC4 KRTAP13-4 KRTAP13-2 KRT74 KRT81 KRT82 KRT83 KRTAP19-5 KRTAP19-7 KRT86 RUSC1 KRTAP7-1 KRTAP13-1 CSRP3 TUBAL3	2.81e-07	1179	63	16	GO:0099512
GeneOntologyCellularComponent	supramolecular polymer	KRT5 HDAC4 KRTAP13-4 KRTAP13-2 KRT74 KRT81 KRT82 KRT83 KRTAP19-5 KRTAP19-7 KRT86 RUSC1 KRTAP7-1 KRTAP13-1 CSRP3 TUBAL3	3.07e-07	1187	63	16	GO:0099081
GeneOntologyCellularComponent	polymeric cytoskeletal fiber	KRT5 KRTAP13-4 KRTAP13-2 KRT74 KRT81 KRT82 KRT83 KRTAP19-5 KRTAP19-7 KRT86 RUSC1 KRTAP7-1 KRTAP13-1 TUBAL3	3.50e-07	899	63	14	GO:0099513
GeneOntologyCellularComponent	keratin filament	KRT5 KRT74 KRT81 KRT82 KRT83 KRT86	4.69e-07	97	63	6	GO:0045095
HumanPheno	Perifollicular hyperkeratosis	KRT81 KRT83 KRT86	5.30e-07	4	27	3	HP:0007468
HumanPheno	Abnormal perifollicular morphology	KRT81 KRT83 KRT86	2.63e-06	6	27	3	HP:0031285
HumanPheno	Abnormality of hair growth rate	KRT74 KRT81 KRT83 KRT86	1.36e-05	29	27	4	HP:0011363
HumanPheno	Slow-growing hair	KRT74 KRT81 KRT83 KRT86	1.36e-05	29	27	4	HP:0002217
HumanPheno	Abnormality of hair growth	KRT74 KRT81 KRT83 KRT86	1.56e-05	30	27	4	HP:0040170
HumanPheno	Keratosis pilaris	KRT74 KRT81 KRT83 KRT86	3.67e-05	37	27	4	HP:0032152
HumanPheno	Nail dysplasia	KRT5 KRT74 KRT81 KRT83 KRT86 IL17RC WRAP53 NOTCH2	4.39e-05	264	27	8	HP:0002164
HumanPheno	Abnormal eyelash morphology	HSPG2 KRT74 KRT81 KRT83 KRT86 WRAP53 TMCO1 NOTCH2	7.41e-05	284	27	8	HP:0000499
HumanPheno	Nail dystrophy	KRT5 KRT74 KRT81 KRT83 KRT86 WRAP53	1.30e-04	156	27	6	HP:0008404
HumanPheno	Hyperkeratosis	KRT5 KRT74 KRT81 KRT83 KRT86 IL17RC WRAP53	1.55e-04	233	27	7	HP:0000962
HumanPheno	Brittle hair	KRT74 KRT81 KRT83 KRT86	1.65e-04	54	27	4	HP:0002299
HumanPheno	Abnormality of keratinization	KRT5 KRT74 KRT81 KRT83 KRT86 IL17RC WRAP53	2.07e-04	244	27	7	HP:0001035
HumanPheno	Abnormality of the dentition	HSPG2 KRT5 HDAC4 KRT74 KRT81 KRT83 KRT86 ADAMTS15 ELANE IL17RC WRAP53 TMCO1 WNK3 NOTCH2	2.47e-04	1030	27	14	HP:0000164
HumanPheno	Patchy alopecia	KRT81 KRT83 KRT86	3.18e-04	26	27	3	HP:0002232
Domain	Keratin_2_head	KRT5 KRT74 KRT81 KRT82 KRT83 KRT86	1.34e-10	24	62	6	IPR032444
Domain	Keratin_2_head	KRT5 KRT74 KRT81 KRT82 KRT83 KRT86	1.34e-10	24	62	6	PF16208
Domain	Keratin_II	KRT5 KRT74 KRT81 KRT82 KRT83 KRT86	2.28e-10	26	62	6	IPR003054
Domain	Intermediate_filament_CS	KRT5 KRT74 KRT81 KRT82 KRT83 KRT86	6.12e-08	63	62	6	IPR018039
Domain	Filament	KRT5 KRT74 KRT81 KRT82 KRT83 KRT86	1.26e-07	71	62	6	SM01391
Domain	IF	KRT5 KRT74 KRT81 KRT82 KRT83 KRT86	1.38e-07	72	62	6	PS00226
Domain	Filament	KRT5 KRT74 KRT81 KRT82 KRT83 KRT86	1.50e-07	73	62	6	PF00038
Domain	IF	KRT5 KRT74 KRT81 KRT82 KRT83 KRT86	1.91e-07	76	62	6	IPR001664
Domain	EGF	HSPG2 CNTNAP1 CUBN NOTCH2 CRB2 STAB1	3.77e-06	126	62	6	PF00008
Domain	PMG	KRTAP13-4 KRTAP13-2 KRTAP13-1	9.73e-06	13	62	3	PF05287
Domain	KRTAP_PMG	KRTAP13-4 KRTAP13-2 KRTAP13-1	9.73e-06	13	62	3	IPR007951
Domain	EGF_3	HSPG2 HHIP CNTNAP1 CUBN NOTCH2 CRB2 STAB1	1.25e-05	235	62	7	PS50026
Domain	EGF	HSPG2 HHIP CNTNAP1 CUBN NOTCH2 CRB2 STAB1	1.25e-05	235	62	7	SM00181
Domain	EGF-like_dom	HSPG2 HHIP CNTNAP1 CUBN NOTCH2 CRB2 STAB1	1.81e-05	249	62	7	IPR000742
Domain	EGF_1	HSPG2 HHIP CNTNAP1 CUBN NOTCH2 CRB2 STAB1	2.11e-05	255	62	7	PS00022
Domain	EGF-like_CS	HSPG2 HHIP CNTNAP1 CUBN NOTCH2 CRB2 STAB1	2.45e-05	261	62	7	IPR013032
Domain	EGF_2	HSPG2 HHIP CNTNAP1 CUBN NOTCH2 CRB2 STAB1	2.70e-05	265	62	7	PS01186
Domain	AA-permease/SLC12A_dom	SLC12A6 SLC7A2 SLC12A5	5.13e-05	22	62	3	IPR004841
Domain	AA_permease	SLC12A6 SLC7A2 SLC12A5	5.13e-05	22	62	3	PF00324
Domain	EGF_CA	HSPG2 CUBN NOTCH2 CRB2 STAB1	5.26e-05	122	62	5	SM00179
Domain	EGF-like_Ca-bd_dom	HSPG2 CUBN NOTCH2 CRB2 STAB1	5.69e-05	124	62	5	IPR001881
Domain	KCL_cotranspt	SLC12A6 SLC12A5	6.48e-05	4	62	2	IPR000076
Domain	Growth_fac_rcpt_	HSPG2 KRT83 CUBN NOTCH2 STAB1	1.68e-04	156	62	5	IPR009030
Domain	SLC12A_fam	SLC12A6 SLC12A5	2.25e-04	7	62	2	IPR004842
Domain	LAM_G_DOMAIN	HSPG2 CNTNAP1 CRB2	2.71e-04	38	62	3	PS50025
Domain	SLC12_C	SLC12A6 SLC12A5	3.00e-04	8	62	2	IPR018491
Domain	SLC12	SLC12A6 SLC12A5	3.00e-04	8	62	2	PF03522
Domain	Laminin_G_2	HSPG2 CNTNAP1 CRB2	3.15e-04	40	62	3	PF02210
Domain	LamG	HSPG2 CNTNAP1 CRB2	4.19e-04	44	62	3	SM00282
Domain	CUB	DMBT1 CUBN CSMD2	5.76e-04	49	62	3	PF00431
Domain	CUB	DMBT1 CUBN CSMD2	6.11e-04	50	62	3	SM00042
Domain	-	DMBT1 CUBN CSMD2	6.86e-04	52	62	3	2.60.120.290
Domain	EGF_3	CUBN STAB1	7.00e-04	12	62	2	PF12947
Domain	EGF_dom	CUBN STAB1	7.00e-04	12	62	2	IPR024731
Domain	CUB	DMBT1 CUBN CSMD2	7.25e-04	53	62	3	PS01180
Domain	CUB_dom	DMBT1 CUBN CSMD2	8.97e-04	57	62	3	IPR000859
Domain	Laminin_G	HSPG2 CNTNAP1 CRB2	9.44e-04	58	62	3	IPR001791
Domain	KRTAP	KRTAP19-5 KRTAP19-7	1.11e-03	15	62	2	PF11759
Domain	KRTAP_type6/8/16/19/20/21	KRTAP19-5 KRTAP19-7	1.11e-03	15	62	2	IPR021743
Domain	Ald_DH_CS_GLU	ALDH2 ALDH9A1	1.26e-03	16	62	2	IPR029510
Domain	Ald_DH_CS_CYS	ALDH2 ALDH9A1	1.43e-03	17	62	2	IPR016160
Domain	ALDEHYDE_DEHYDR_GLU	ALDH2 ALDH9A1	1.60e-03	18	62	2	PS00687
Domain	ALDEHYDE_DEHYDR_CYS	ALDH2 ALDH9A1	1.60e-03	18	62	2	PS00070
Domain	Ald_DH_C	ALDH2 ALDH9A1	1.79e-03	19	62	2	IPR016163
Domain	Ald_DH_N	ALDH2 ALDH9A1	1.79e-03	19	62	2	IPR016162
Domain	Ald_DH/histidinol_DH	ALDH2 ALDH9A1	1.79e-03	19	62	2	IPR016161
Domain	-	ALDH2 ALDH9A1	1.79e-03	19	62	2	3.40.605.10
Domain	Aldedh	ALDH2 ALDH9A1	1.79e-03	19	62	2	PF00171
Domain	Aldehyde_DH_dom	ALDH2 ALDH9A1	1.79e-03	19	62	2	IPR015590
Domain	-	ALDH2 ALDH9A1	1.79e-03	19	62	2	3.40.309.10
Domain	hEGF	NOTCH2 CRB2	3.88e-03	28	62	2	PF12661
Domain	-	HSPG2 CNTNAP1 CRB2	3.88e-03	95	62	3	2.60.120.200
Domain	EGF_Ca-bd_CS	CUBN NOTCH2 CRB2	4.11e-03	97	62	3	IPR018097
Domain	EGF_CA	CUBN NOTCH2 CRB2	4.36e-03	99	62	3	PS01187
Domain	EGF_LAM_2	HSPG2 STAB1	4.44e-03	30	62	2	PS50027
Domain	EGF_LAM_1	HSPG2 STAB1	4.44e-03	30	62	2	PS01248
Domain	ASX_HYDROXYL	CUBN NOTCH2 CRB2	4.48e-03	100	62	3	PS00010
Domain	EGF-type_Asp/Asn_hydroxyl_site	CUBN NOTCH2 CRB2	5.27e-03	106	62	3	IPR000152
Domain	Laminin_EGF	HSPG2 STAB1	6.01e-03	35	62	2	PF00053
Domain	EGF_Lam	HSPG2 STAB1	6.01e-03	35	62	2	SM00180
Domain	Laminin_EGF	HSPG2 STAB1	7.06e-03	38	62	2	IPR002049
Pathway	REACTOME_KERATINIZATION	KRT5 KRTAP13-4 KRTAP13-2 KRT74 KRT81 KRT82 KRT83 KRTAP19-5 KRTAP19-7 KRT86 KRTAP13-1	2.74e-12	153	48	11	MM15343
Pathway	REACTOME_KERATINIZATION	KRT5 KRTAP13-4 KRTAP13-2 KRT74 KRT81 KRT82 KRT83 KRTAP19-5 KRTAP19-7 KRT86 KRTAP13-1	1.22e-10	217	48	11	M27640
Pathway	REACTOME_DEVELOPMENTAL_BIOLOGY	KRT5 KRTAP13-4 KRTAP13-2 KRT74 KRT81 KRT82 KRT83 KRTAP19-5 KRTAP19-7 KRT86 KRTAP13-1 TUBAL3	7.90e-08	502	48	12	MM14537
Pathway	REACTOME_FORMATION_OF_THE_CORNIFIED_ENVELOPE	KRT5 KRT74 KRT81 KRT82 KRT83 KRT86	4.63e-07	87	48	6	MM15351
Pathway	REACTOME_FORMATION_OF_THE_CORNIFIED_ENVELOPE	KRT5 KRT74 KRT81 KRT82 KRT83 KRT86	4.68e-06	129	48	6	M27649
Pathway	KEGG_HISTIDINE_METABOLISM	ALDH2 ALDH9A1 LCMT2	1.27e-04	29	48	3	M12524
Pathway	WP_FLUOROACETIC_ACID_TOXICITY	ALDH2 ALDH9A1	1.69e-04	6	48	2	M40063
Pathway	REACTOME_CATION_COUPLED_CHLORIDE_COTRANSPORTERS	SLC12A6 SLC12A5	2.36e-04	7	48	2	M27339
Pathway	REACTOME_CATION_COUPLED_CHLORIDE_COTRANSPORTERS	SLC12A6 SLC12A5	2.36e-04	7	48	2	MM15081
Pathway	KEGG_LIMONENE_AND_PINENE_DEGRADATION	ALDH2 ALDH9A1	5.02e-04	10	48	2	M17395
Pathway	REACTOME_DEVELOPMENTAL_BIOLOGY	KRT5 KRTAP13-4 KRTAP13-2 KRT74 KRT81 KRT82 KRT83 KRTAP19-5 KRTAP19-7 KRT86 CNTNAP1 KRTAP13-1 TUBAL3	7.48e-04	1432	48	13	M509
Pubmed	Characterization of a first domain of human high glycine-tyrosine and high sulfur keratin-associated protein (KAP) genes on chromosome 21q22.1.	KRTAP13-4 KRTAP13-2 KRTAP19-5 KRTAP19-7 KRTAP7-1 KRTAP13-1	1.12e-10	40	64	6	12359730
Pubmed	New consensus nomenclature for mammalian keratins.	KRT5 KRT74 KRT81 KRT82 KRT83 KRT86	1.91e-09	63	64	6	16831889
Pubmed	Molecular evolution of the keratin associated protein gene family in mammals, role in the evolution of mammalian hair.	KRTAP13-4 KRTAP13-2 KRTAP19-5 KRTAP19-7 KRTAP7-1 KRTAP13-1	3.34e-09	69	64	6	18721477
Pubmed	Characterization of a 300 kbp region of human DNA containing the type II hair keratin gene domain.	KRT81 KRT82 KRT83 KRT86	5.10e-09	12	64	4	10692104
Pubmed	Structure and site of expression of a murine type II hair keratin.	KRT81 KRT83 KRT86	5.94e-09	3	64	3	1372089
Pubmed	Transient expression of mouse hair keratins in transfected HeLa cells: interactions between "hard" and "soft" keratins.	KRT81 KRT83 KRT86	5.94e-09	3	64	3	1712823
Pubmed	Novel KRT83 and KRT86 mutations associated with monilethrix.	KRT81 KRT83 KRT86	5.94e-09	3	64	3	25557232
Pubmed	Hague (Hag). A new mouse hair mutation with an unstable semidominant allele.	KRT5 KRT81 KRT82 KRT86	1.87e-08	16	64	4	12399393
Pubmed	Comprehensive analysis of keratin gene clusters in humans and rodents.	KRT74 KRT81 KRT83 KRT86	1.87e-08	16	64	4	15085952
Pubmed	Keratins of the human hair follicle.	KRT81 KRT83 KRT86	2.37e-08	4	64	3	15797458
Pubmed	Charting the molecular network of the drug target Bcr-Abl.	DCAF1 HSPG2 KRT5 KRT81 KRT82 KRT83 KRT86 TUBAL3	3.22e-08	266	64	8	19380743
Pubmed	Similar effects of all WNK3 variants on SLC12 cotransporters.	SLC12A6 WNK3 SLC12A5	3.31e-07	8	64	3	21613606
Pubmed	WNK3 Maintains the GABAergic Inhibitory Tone, Synaptic Excitation and Neuronal Excitability via Regulation of KCC2 Cotransporter in Mature Neurons.	SLC12A6 WNK3	3.33e-06	2	64	2	34858138
Pubmed	A missense mutation in the type II hair keratin hHb3 is associated with monilethrix.	KRT83 KRT86	3.33e-06	2	64	2	15744029
Pubmed	A variable monilethrix phenotype associated with a novel mutation, Glu402Lys, in the helix termination motif of the type II hair keratin hHb1.	KRT81 KRT86	3.33e-06	2	64	2	9665406
Pubmed	A new mutation in the type II hair cortex keratin hHb1 involved in the inherited hair disorder monilethrix.	KRT81 KRT86	3.33e-06	2	64	2	9402962
Pubmed	Krtap16, characterization of a new hair keratin-associated protein (KAP) gene complex on mouse chromosome 16 and evidence for regulation by Hoxc13.	KRTAP19-5 KRTAP19-7 KRTAP7-1	3.97e-06	17	64	3	15385554
Pubmed	PERP regulates enamel formation via effects on cell-cell adhesion and gene expression.	KRT81 KRT83 KRT86	5.64e-06	19	64	3	21285247
Pubmed	Deletion of the epidermis derived laminin γ1 chain leads to defects in the regulation of late hair morphogenesis.	KRT81 KRT82 KRT86	5.64e-06	19	64	3	27234308
Pubmed	Sequence data and chromosomal localization of human type I and type II hair keratin genes.	KRT81 KRT86	9.99e-06	3	64	2	7556444
Pubmed	Raising cytosolic Cl- in cerebellar granule cells affects their excitability and vestibulo-ocular learning.	SLC12A6 SLC12A5	9.99e-06	3	64	2	22252133
Pubmed	Sequences and differential expression of three novel human type-II hair keratins.	KRT83 KRT86	9.99e-06	3	64	2	9084137
Pubmed	HDAC4 and PCAF bind to cardiac sarcomeres and play a role in regulating myofilament contractile activity.	HDAC4 CSRP3	9.99e-06	3	64	2	18250163
Pubmed	HHIP, HDAC4, NCR3 and RARB polymorphisms affect fetal, childhood and adult lung function.	HHIP HDAC4	2.00e-05	4	64	2	23456936
Pubmed	Secreted HHIP1 interacts with heparan sulfate and regulates Hedgehog ligand localization and function.	HSPG2 HHIP	2.00e-05	4	64	2	26056142
Pubmed	Characterization and chromosomal localization of human hair-specific keratin genes and comparative expression during the hair growth cycle.	KRT81 KRT86	2.00e-05	4	64	2	9457912
Pubmed	Influence of K-Cl cotransporter activity on activation of volume-sensitive Cl- channels in human osteoblasts.	SLC12A6 SLC12A5	2.00e-05	4	64	2	12637262
Pubmed	Perlecan is recruited by dystroglycan to nodes of Ranvier and binds the clustering molecule gliomedin.	HSPG2 CNTNAP1	2.00e-05	4	64	2	25646087
Pubmed	ΔNp63 knockout mice reveal its indispensable role as a master regulator of epithelial development and differentiation.	HSPG2 KRT5 NOTCH2	2.57e-05	31	64	3	22274697
Pubmed	Sites of regulated phosphorylation that control K-Cl cotransporter activity.	SLC12A6 SLC12A5	3.32e-05	5	64	2	19665974
Pubmed	Functional analysis and identification of cis-regulatory elements of human chromosome 21 gene promoters.	KRTAP13-4 KRTAP13-2 KRTAP19-5	3.41e-05	34	64	3	20494980
Pubmed	C5orf51 is a component of the MON1-CCZ1 complex and controls RAB7A localization and stability during mitophagy.	SLC12A6 SLC7A2 FNIP1 REEP5 TMCO1 WDR59 NOTCH2	3.92e-05	504	64	7	34432599
Pubmed	KCC3 loss-of-function contributes to Andermann syndrome by inducing activity-dependent neuromuscular junction defects.	SLC12A6 SLC12A5	4.98e-05	6	64	2	28647557
Pubmed	Parent stem cells can serve as niches for their daughter cells.	KRT5 NOTCH2	6.96e-05	7	64	2	26147083
Pubmed	A genome-wide metabolic QTL analysis in Europeans implicates two loci shaped by recent positive selection.	PYROXD2 DUSP11	6.96e-05	7	64	2	21931564
Pubmed	Disruption of KCC2 reveals an essential role of K-Cl cotransport already in early synaptic inhibition.	SLC12A6 SLC12A5	9.27e-05	8	64	2	11395011
Pubmed	The WNK-regulated SPAK/OSR1 kinases directly phosphorylate and inhibit the K+-Cl- co-transporters.	SLC12A6 SLC12A5	9.27e-05	8	64	2	24393035
Pubmed	Loss of K-Cl co-transporter KCC3 causes deafness, neurodegeneration and reduced seizure threshold.	SLC12A6 SLC12A5	1.19e-04	9	64	2	14532115
Pubmed	Cation-chloride cotransporters and neuronal function.	SLC12A6 SLC12A5	1.19e-04	9	64	2	19323993
Pubmed	Isolation and characterization of mouse high-glycine/tyrosine proteins.	KRTAP19-5 KRTAP19-7	1.49e-04	10	64	2	9374545
Pubmed	A CRISPR-based screen for Hedgehog signaling provides insights into ciliary function and ciliopathies.	KRT5 KRT81 KRT83 KRT86 ADAMTS15	1.80e-04	284	64	5	29459677
Pubmed	Functional kinomics establishes a critical node of volume-sensitive cation-Cl- cotransporter regulation in the mammalian brain.	SLC12A6 WNK3	2.17e-04	12	64	2	27782176
Pubmed	Deficiency in Crumbs homolog 2 (Crb2) affects gastrulation and results in embryonic lethality in mice.	HSPG2 CRB2	2.17e-04	12	64	2	22072575
Pubmed	Overexpression of Hoxc13 in differentiating keratinocytes results in downregulation of a novel hair keratin gene cluster and alopecia.	KRTAP19-5 KRTAP19-7	2.17e-04	12	64	2	11290294
Pubmed	Protein-protein interaction panel using mouse full-length cDNAs.	KRT5 KRTAP13-2 KRTAP13-1 REEP5	2.26e-04	161	64	4	11591653
Pubmed	DYRK1a mediates BAFF-induced noncanonical NF-κB activation to promote autoimmunity and B-cell leukemogenesis.	KRT81 KRT83 KRT86	2.98e-04	70	64	3	34255829
Pubmed	Multiple roles of Notch signaling in the regulation of epidermal development.	KRT5 NOTCH2	3.45e-04	15	64	2	18410734
Pubmed	Efficient and fast targeted production of murine models based on ENU mutagenesis.	GBE1 CRB2	3.45e-04	15	64	2	16075367
Pubmed	Identification of novel keratinocyte-secreted peptides dermokine-alpha/-beta and a new stratified epithelium-secreted protein gene complex on human chromosome 19q13.1.	KRTAP19-5 KRTAP19-7	5.59e-04	19	64	2	15234001
Pubmed	Crumbs3-Mediated Polarity Directs Airway Epithelial Cell Fate through the Hippo Pathway Effector Yap.	KRT5 CRB2	5.59e-04	19	64	2	26235047
Pubmed	Differential requirement of SUFU in tissue development discovered in a hypomorphic mouse model.	KRT5 HHIP	6.84e-04	21	64	2	28688895
Pubmed	Shotgun proteomics reveals specific modulated protein patterns in tears of patients with primary open angle glaucoma naïve to therapy.	KRT81 KRT83 KRT86	7.52e-04	96	64	3	23580065
Pubmed	E3 ubiquitin ligase FBXW7 balances airway cell fates.	KRT5 NOTCH2	7.52e-04	22	64	2	34998785
Pubmed	E3 ubiquitin ligase RFWD2 controls lung branching through protein-level regulation of ETV transcription factors.	KRT5 CUBN	7.52e-04	22	64	2	27335464
Pubmed	Rare independent mutations in renal salt handling genes contribute to blood pressure variation.	SLC12A6 SLC12A5	7.52e-04	22	64	2	18391953
Pubmed	Aldehyde dehydrogenase 1a1 is dispensable for stem cell function in the mouse hematopoietic and nervous systems.	ALDH2 ALDH9A1	8.23e-04	23	64	2	18971422
Pubmed	Aberrant epidermal differentiation and disrupted ΔNp63/Notch regulatory axis in Ets1 transgenic mice.	KRT5 NOTCH2	8.23e-04	23	64	2	24337118
Pubmed	Loss of Hs3st3a1 or Hs3st3b1 enzymes alters heparan sulfate to reduce epithelial morphogenesis and adult salivary gland function.	HSPG2 KRT5	8.96e-04	24	64	2	34653670
Pubmed	Interaction mapping of endoplasmic reticulum ubiquitin ligases identifies modulators of innate immune signalling.	SLC7A2 ALDH9A1 TMCO1 NOTCH2	9.40e-04	235	64	4	32614325
Pubmed	DDX24 promotes metastasis by regulating RPL5 in non-small cell lung cancer.	KRT5 KRT74 KRT82 KRT83	9.85e-04	238	64	4	35864588
Pubmed	Canonical Notch signaling controls the early thymic epithelial progenitor cell state and emergence of the medullary epithelial lineage in fetal thymus development.	KRT5 NOTCH2	1.05e-03	26	64	2	32467237
Pubmed	Assessment of community efforts to advance network-based prediction of protein-protein interactions.	KRT5 KRTAP13-2 KRT74 KRT81 KRT82 KRT83	1.06e-03	630	64	6	36949045
Pubmed	Identification of 15 loci influencing height in a Korean population.	HHIP LINC02875	1.14e-03	27	64	2	19893584
Pubmed	Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.	MFSD2A RUSC1 B3GNT3 CUBN MS4A7	1.18e-03	430	64	5	16303743
Pubmed	An essential function for autocrine hedgehog signaling in epithelial proliferation and differentiation in the trachea.	KRT5 HHIP	1.22e-03	28	64	2	35112129
Pubmed	Molecular genetics of adult ADHD: converging evidence from genome-wide association and extended pedigree linkage studies.	CSMD2 REEP5	1.22e-03	28	64	2	18839057
Pubmed	Large-scale cDNA transfection screening for genes related to cancer development and progression.	MFSD2A ERVMER34-1 WDR59	1.24e-03	114	64	3	15498874
Pubmed	A SHH-FOXF1-BMP4 signaling axis regulating growth and differentiation of epithelial and mesenchymal tissues in ureter development.	KRT5 HHIP	1.31e-03	29	64	2	28797033
Pubmed	Follow-up association studies of chromosome region 9q and nonsyndromic cleft lip/palate.	FOXE1 CRB2	1.40e-03	30	64	2	20583170
Pubmed	Activation of Wnt signaling reduces ipsilaterally projecting retinal ganglion cells in pigmented retina.	HHIP NOTCH2	1.50e-03	31	64	2	30254141
Pubmed	Myosin heavy chain-embryonic regulates skeletal muscle differentiation during mammalian development.	ADAMTS15 CSRP3	1.70e-03	33	64	2	32094117
Pubmed	Delayed Hair Follicle Morphogenesis and Hair Follicle Dystrophy in a Lipoatrophy Mouse Model of Pparg Total Deletion.	KRT5 ELANE	1.70e-03	33	64	2	28964716
Interaction	KRT33B interactions	KRT5 HDAC4 KRT74 KRT81 KRT82 KRT83 KRT86	1.78e-08	93	64	7	int:KRT33B
Interaction	KRT34 interactions	KRT5 HDAC4 KRT74 KRT81 KRT82 KRT83 KRTAP19-5 KRTAP19-7 KRT86 KRTAP13-1	1.98e-08	283	64	10	int:KRT34
Interaction	KRT35 interactions	KRT5 HDAC4 KRT74 KRT81 KRT82 KRT83 KRT86	6.09e-08	111	64	7	int:KRT35
Interaction	KRT25 interactions	KRT5 KRT74 KRT81 KRT83 KRT86	8.31e-08	35	64	5	int:KRT25
Interaction	KRT36 interactions	KRT5 KRT74 KRT81 KRT82 KRT83 KRT86	1.26e-07	74	64	6	int:KRT36
Interaction	PITX1 interactions	KRTAP13-2 KRT83 KRTAP19-5 KRTAP19-7 KRTAP7-1 KRTAP13-1	3.09e-06	127	64	6	int:PITX1
Interaction	KRT27 interactions	KRT5 HDAC4 KRT74 KRT81 KRT82 KRT83 KRT86	3.51e-06	202	64	7	int:KRT27
Interaction	KRT37 interactions	KRT5 KRT74 KRT81 KRT83 KRT86	1.64e-05	100	64	5	int:KRT37
Interaction	C11orf16 interactions	KRTAP19-5 KRTAP19-7 KRTAP7-1	1.66e-05	16	64	3	int:C11orf16
Interaction	KRT38 interactions	KRT5 HDAC4 KRT74 KRT81 KRT83 KRT86	1.76e-05	172	64	6	int:KRT38
Interaction	RHOXF2 interactions	KRTAP13-4 KRTAP13-2 KRTAP19-5 KRTAP19-7 KRTAP7-1	1.99e-05	104	64	5	int:RHOXF2
Interaction	KRT15 interactions	KRT5 KRT74 KRT81 KRT82 KRT83 KRT86	2.14e-05	178	64	6	int:KRT15
Interaction	PRR13 interactions	KRTAP19-5 KRTAP19-7 KRTAP7-1 KRTAP13-1	3.00e-05	56	64	4	int:PRR13
Interaction	ZIC1 interactions	KRTAP13-2 KRTAP19-5 KRTAP19-7 RUSC1 KRTAP7-1	3.37e-05	116	64	5	int:ZIC1
Interaction	KRT39 interactions	KRT74 KRT81 KRT83 KRT86	3.69e-05	59	64	4	int:KRT39
Interaction	KRT16 interactions	KRT5 KRT74 KRT81 KRT82 KRT83 KRT86	3.78e-05	197	64	6	int:KRT16
Interaction	OIP5 interactions	KRTAP13-2 KRT81 KRT83 KRTAP19-5 KRT86 RUSC1	6.48e-05	217	64	6	int:OIP5
Interaction	EPS15 interactions	DCAF1 KRT5 KRT82 KRT83 KRT86 WNK3	6.99e-05	220	64	6	int:EPS15
Interaction	KRT28 interactions	KRT5 KRT81 KRT86	1.17e-04	30	64	3	int:KRT28
Interaction	OTX1 interactions	KRTAP13-2 KRT81 KRTAP19-7 KRTAP7-1 KRTAP13-1	1.33e-04	155	64	5	int:OTX1
Interaction	KRT19 interactions	KRT5 KRT74 KRT81 KRT82 KRT83 KRT86	2.70e-04	282	64	6	int:KRT19
Interaction	OR6M1 interactions	RHBDD1 HERC3	2.75e-04	8	64	2	int:OR6M1
Cytoband	21q22.1	KRTAP13-4 KRTAP13-2 KRTAP19-5 KRTAP19-7 KRTAP7-1 KRTAP13-1	1.82e-11	39	64	6	21q22.1
Cytoband	12q13	KRT81 KRT82 KRT83 KRT86	3.11e-06	71	64	4	12q13
Cytoband	Ensembl 112 genes in cytogenetic band chr21q22	KRTAP13-4 KRTAP13-2 KRTAP19-5 KRTAP19-7 KRTAP7-1 KRTAP13-1	1.48e-05	377	64	6	chr21q22
Cytoband	Ensembl 112 genes in cytogenetic band chr12q13	KRT5 KRT74 KRT81 KRT82 KRT83 KRT86	2.82e-05	423	64	6	chr12q13
Cytoband	Ensembl 112 genes in cytogenetic band chr5q22	REEP5 PGGT1B	3.11e-03	59	64	2	chr5q22
Cytoband	12q13.13	KRT5 KRT74	3.99e-03	67	64	2	12q13.13
GeneFamily	Keratins, type II	KRT5 KRT74 KRT81 KRT82 KRT83 KRT86	4.15e-11	27	44	6	609
GeneFamily	Keratin associated proteins	KRTAP13-4 KRTAP13-2 KRTAP19-5 KRTAP19-7 KRTAP7-1 KRTAP13-1	2.45e-07	109	44	6	619
GeneFamily	Aldehyde dehydrogenases	ALDH2 ALDH9A1	9.64e-04	19	44	2	398
Coexpression	HOLLERN_SQUAMOUS_BREAST_TUMOR	KRT5 KRTAP13-4 KRTAP13-2 KRT81 KRT83 KRTAP19-5 KRTAP19-7 KRT86 KRTAP13-1	1.67e-09	204	64	9	MM966
Coexpression	MARTINEZ_RB1_TARGETS_DN	KRTAP13-4 KRTAP13-2 KRT81 KRT82 KRT83 KRTAP19-5 KRTAP19-7 KRT86 KRTAP13-1 CSRP3	2.82e-06	630	64	10	MM1038
Coexpression	MARTINEZ_RB1_AND_TP53_TARGETS_DN	HHIP KRTAP13-4 KRTAP13-2 KRT81 KRT82 KRT83 KRTAP19-5 KRTAP19-7 KRT86 KRTAP13-1	3.72e-06	650	64	10	MM1042
Coexpression	HOLLERN_SQUAMOUS_BREAST_TUMOR	KRT5 KRTAP13-4 KRTAP13-2 KRT81 KRT83 KRT86	4.14e-06	173	64	6	M650
Coexpression	MARTINEZ_TP53_TARGETS_DN	HHIP KRTAP13-4 KRTAP13-2 KRT81 KRT82 KRT83 KRTAP19-5 KRTAP19-7 KRT86 KRTAP13-1	4.20e-06	659	64	10	MM1040
ToppCell	TCGA-Skin-Metastatic-Melanoma-Skin_Cutaneous_Melanoma-6\|TCGA-Skin / Sample_Type by Project: Shred V9	KRT74 KRT82 KRT83 KRTAP19-5 KRTAP7-1 KRTAP13-1	6.76e-08	146	64	6	522c32103c24fc26836bb5b642083904682d9292
ToppCell	TCGA-Bladder-Primary_Tumor-Urothelial_Carcinoma-Papillary_Muscle_Invasive_Urothelial_Carcinoma-10\|TCGA-Bladder / Sample_Type by Project: Shred V9	KRTAP13-4 KRT81 KRTAP19-7 KRTAP7-1 KRTAP13-1	1.19e-06	129	64	5	6a201c6344a015e5cf2f79ccf397fd7ad66b6768
ToppCell	FF-Differ-KC\|World / shred by cell class for mouse tongue	HHIP KRT81 KRT82 KRT83 KRT86	5.94e-06	179	64	5	1526a130565a97c291a25a7a988089bffc1515c1
ToppCell	COPD-Epithelial-ATII\|COPD / Disease state, Lineage and Cell class	MFSD2A SLC7A2 HHIP KRT86 DMBT1	7.54e-06	188	64	5	eb6d79d733b53f64ca615bb777c64ed456866549
ToppCell	droplet-Tongue-nan-3m-Epithelial-filiform\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HHIP KRT81 KRT83 KRT86 KRTAP13-1	7.94e-06	190	64	5	251e3a33041023bfc4b547c7eb68cfb8f421636f
ToppCell	droplet-Tongue-nan-24m-Epithelial-nan\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KRT81 KRT83 KRT86 KRTAP13-1	1.54e-05	104	64	4	a4ae3cae44aac8b6e0d14896f9acab44f0cc97c4
ToppCell	PND07-28-samps-Myeloid-Macrophage-macrophage-A\|PND07-28-samps / Age Group, Lineage, Cell class and subclass	KRT5 KRT81 ELANE DMBT1	2.06e-05	112	64	4	d21cfcb04a27cc9fb74e0c2afa8a8cdfb886ae21
ToppCell	droplet-Tongue-Unstain-18m-Epithelial-nan\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KRT81 KRT86 KRTAP13-1 NOTCH2	4.04e-05	133	64	4	f7d0763b5eec2db33044d6850fd57462494038c1
ToppCell	Basal_cells-Donor_05\|World / lung cells shred on cell class, cell subclass, sample id	KRT5 GRID2IP ERVMER34-1 KCNH4	7.33e-05	155	64	4	30accc72a6a914ae0c4d52b373ea1c9a98efbf22
ToppCell	Leuk-UTI-Lymphocyte-T_NK-NK_CD56bright\|Leuk-UTI / Disease, Lineage and Cell Type	GRID2IP KRT81 KRT86 PYROXD2	7.70e-05	157	64	4	db0057741d06e212a9543cb4b011659b79efeafc
ToppCell	Transplant_Alveoli_and_parenchyma-Epithelial-Basal_2\|Epithelial / Tissue, Lineage and Cell class of Lung Cells from 10X	FOXE1 KRT5 LINC02875 ADAMTS15	8.91e-05	163	64	4	f21951e63188eb0c04675a8f81a0da495c26c007
ToppCell	10x5'-GI_small-bowel-Lymphocytic_NK-NK_CD56bright_CD16-\|GI_small-bowel / Manually curated celltypes from each tissue	HHIP KRT81 KRT83 KRT86	9.12e-05	164	64	4	36e64e4f717dd59b352c20ff9742ca1e232342bb
ToppCell	ILEUM-non-inflamed-(3)_MNP-(3)_pDC\|(3)_MNP / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	KRT5 KRT81 KRT86 CRB2	9.78e-05	167	64	4	8ddf9da71a7c4ed53588435db826563a24cee616
ToppCell	367C-Lymphocytic-ILC-ILC-1\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	KRT81 KRT86 IL17RC STAB1	1.00e-04	168	64	4	80233a13135fd159f5764336a1fe67fba237776b
ToppCell	facs-Marrow-KLS-3m-Lymphocytic-immature_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HSPG2 DMBT1 TUBAL3 BEGAIN	1.12e-04	173	64	4	8bffd512a4e561e23cc04478e2ca6fd5d3771fe4
ToppCell	facs-Marrow-KLS-3m-Lymphocytic-immature_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HSPG2 DMBT1 TUBAL3 BEGAIN	1.12e-04	173	64	4	3e3c61468e703330788a10d850ef41a85680f86d
ToppCell	BAL-Mild-Epithelial-Epithelial-AT1/AT2\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	UNC13C CSMD2 ERVMER34-1 WNK3	1.15e-04	174	64	4	b7f5492ce8098f7eb0aef30ee558d00738d59d0e
ToppCell	BAL-Mild-Epithelial-Epithelial-AT1/AT2-\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	UNC13C CSMD2 ERVMER34-1 WNK3	1.15e-04	174	64	4	71730503be3d9c839c4c9e950145e2101d682a1c
ToppCell	BAL-Mild-Epithelial-Epithelial-AT1/AT2\|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)	UNC13C CSMD2 ERVMER34-1 WNK3	1.15e-04	174	64	4	ee8ac51fa0b426ad7b7453371bb79c8bf8c1d358
ToppCell	BAL-Mild-Epithelial-Epithelial-AT1/AT2-\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	UNC13C CSMD2 ERVMER34-1 WNK3	1.15e-04	174	64	4	cafe4d6b5f08d8888e9db6e196c66df991c03e7b
ToppCell	(03)_Secretory\|World / shred by cell type and Timepoint	SLC7A2 ALDH2 DMBT1 NOTCH2	1.20e-04	176	64	4	cb7b1945788196ca79007f0768b6576ec885a0e5
ToppCell	Hippocampus-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Calb2-Excitatory_Neuron.Slc17a7.Calb2-Adcyap1_(Dentate_hilum?)\|Hippocampus / BrainAtlas - Mouse McCarroll V32	KRT5 KRT83 CUBN	1.23e-04	67	64	3	52f6c244e8d89ccacb79bc5ef3663a5d01fd393c
ToppCell	Hippocampus-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Calb2-Excitatory_Neuron.Slc17a7.Calb2-Adcyap1_(Dentate_hilum?)-\|Hippocampus / BrainAtlas - Mouse McCarroll V32	KRT5 KRT83 CUBN	1.23e-04	67	64	3	e462f9b5dca7c64101a31891f25654c05f2d215d
ToppCell	Control-Epithelial_cells-AT2\|Control / group, cell type (main and fine annotations)	MFSD2A SLC7A2 HHIP DMBT1	1.31e-04	180	64	4	198b19e7910b4a8cc7e820c525ab357c7f99f578
ToppCell	5'-Adult-LargeIntestine-Mesenchymal-mesothelial_cell\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	KRT5 MFSD2A SLC7A2 CRB2	1.33e-04	181	64	4	65eaa9bc1022bcf0c5f0f92c07a2cbbf11f9b59c
ToppCell	-Myositis-ILD_01\|World / lung cells shred on cell class, cell subclass, sample id	ADAMTS15 WNK3 CRB2 BEGAIN	1.33e-04	181	64	4	ef579e958f334da0f9415aa7e3d5c02c807954a6
ToppCell	5'-Adult-LargeIntestine-Mesenchymal-mesothelial_cell-Mesothelium_(PRG4+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	KRT5 MFSD2A SLC7A2 CRB2	1.33e-04	181	64	4	eaac7d58117eddfff06b25521efc431c1351d592
ToppCell	wk_15-18-Hematologic_Lymphocytic-T_&_ILC-ILCP\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	KRT81 KRT83 KRT86 KCNH4	1.36e-04	182	64	4	6bd48c5d60a259719f65cacee4b8135247e78fa9
ToppCell	droplet-Liver-Npc-21m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HSPG2 KRT5 WDR59 STAB1	1.36e-04	182	64	4	b1ec2015aad1181eac1bbf8d48ad6f2f7ed24a01
ToppCell	COPD-Epithelial-ATII\|World / Disease state, Lineage and Cell class	SLC7A2 HHIP KRT86 DMBT1	1.39e-04	183	64	4	8e9aab4eeec2e282c2cab9bfca6dbf40d660c7b9
ToppCell	3'-GW_trimst-2-SmallIntestine-Hematopoietic-T_cells-LTi-like_NCR+_ILC3\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	KRT81 KRT83 KRT86 KCNH4	1.39e-04	183	64	4	d4a558bc0b8e11be195a7da1468ab38eb477117d
ToppCell	wk_08-11-Hematologic_Lymphocytic-T_&_ILC-ILCP\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	KRT81 KRT83 KRT86 KCNH4	1.39e-04	183	64	4	797eb968c57e48db33ff8e2236ee22e9425c4676
ToppCell	droplet-Pancreas-Exocrine-18m-Epithelial-nan\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADAMTS15 ELANE DMBT1	1.40e-04	70	64	3	26178ee967d647224d93c7a6380f2d15d8fcfb8f
ToppCell	droplet-Tongue-Unstain-18m-Epithelial-filiform\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HHIP KRT81 KRT86 KRTAP13-1	1.45e-04	185	64	4	e0c9e92e35fb24351f5347a0768e6aab5add8775
ToppCell	367C-Lymphocytic-NK_cells-NK_cell_D3\|NK_cells / Donor, Lineage, Cell class and subclass (all cells)	KRT81 PNRC1 MAP3K13 NDUFA11	1.45e-04	185	64	4	4a5e70ac41e5f3b25a773304ffef3c2a3dd5549d
ToppCell	3'-GW_trimst-1-SmallIntestine-Hematopoietic-T_cells-ILCP\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FOXE1 KRT81 KRT83 KRT86	1.45e-04	185	64	4	e1fd66f4295056807aa29c0e4ce6b1a79cc8dfcf
ToppCell	facs-Brain_Non-Myeloid-Striatum_-18m-Neuronal-interneuron\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TMEM151B CNTNAP1 UNC13C MS4A7	1.48e-04	186	64	4	a1ab273b01971d6a892912560d387685dd657179
ToppCell	Control-Epithelial-ATII\|World / Disease state, Lineage and Cell class	MFSD2A SLC7A2 HHIP DMBT1	1.48e-04	186	64	4	f4b6e401e19a71beddc73d8a1e08359f7c4025cf
ToppCell	facs-Brain_Non-Myeloid-Striatum_-18m-Neuronal-nan\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TMEM151B CNTNAP1 UNC13C MS4A7	1.51e-04	187	64	4	ef3c85c01bc3da408ae288b6e3096ad888a12e63
ToppCell	Adult-Epithelial-alveolar_epithelial_cell_type_2-D175\|Adult / Lineage, Cell type, age group and donor	MFSD2A SLC7A2 MAP3K13 DMBT1	1.54e-04	188	64	4	ec38def1fdbb34ed9b30244806975bd5a4370164
ToppCell	droplet-Tongue-Unstain-18m-Epithelial-keratinocyte\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HHIP KRT81 KRT86 KRTAP13-1	1.57e-04	189	64	4	7ee9b00a8bd46f2da9218623bb2617b2e585f9d5
ToppCell	Control-Epithelial-ATII\|Control / Disease state, Lineage and Cell class	MFSD2A SLC7A2 HHIP DMBT1	1.61e-04	190	64	4	d50902a3abcc18aafa36d83cc2c6e07d7f7cb197
ToppCell	COVID-19-lung-AT2\|lung / Disease (COVID-19 only), tissue and cell type	MFSD2A HHIP MAP3K13 DMBT1	1.64e-04	191	64	4	276455a64c2c3503d5048615762eb2ee37f0ac70
ToppCell	droplet-Tongue-Unstain-18m-Epithelial\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KRT5 KRT81 KRT86 KRTAP13-1	1.67e-04	192	64	4	45ff9555f9a9fccc650885956005b2e5b4820a56
ToppCell	Epithelial-alveolar_epithelial_cell_type_2\|World / Lineage, Cell type, age group and donor	MFSD2A HHIP MAP3K13 DMBT1	1.67e-04	192	64	4	58c3737be7acce39fd2b91d70d6d7b2bbaa4f710
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	MFSD2A SLC7A2 HHIP MAP3K13	1.67e-04	192	64	4	cc9911e182a289779a2612bc213daae5607689e7
ToppCell	nucseq-Epithelial-Epithelial_Alveolar-AT2-AT2\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	MFSD2A SLC7A2 HHIP DMBT1	1.71e-04	193	64	4	fd4d3c0d7caf8a2fff5b3d901fc28d19a8163cdf
ToppCell	droplet-Bladder-nan-24m-Epithelial-bladder_mesenchymal_cell_(Car3+)\|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HSPG2 HHIP UNC13C ALDH2	1.71e-04	193	64	4	2d891c00b8f0aace17d4c300b63e2341dcffa199
ToppCell	Adult-Epithelial-alveolar_epithelial_cell_type_2\|Adult / Lineage, Cell type, age group and donor	MFSD2A HHIP MAP3K13 DMBT1	1.71e-04	193	64	4	738f4f0a9ddde2432b429ab46838e353b1790589
ToppCell	nucseq-Epithelial-Epithelial_Alveolar-AT2\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	MFSD2A SLC7A2 HHIP DMBT1	1.71e-04	193	64	4	f3cc7cfdbc164a4ed42f87647111522b7d393bcb
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-24m-Neuronal\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TMEM151B CNTNAP1 UNC13C SLC12A5	1.71e-04	193	64	4	5fb7808dd971c1cc64c2bd4f8f1de646fb2d77f4
ToppCell	5'-Adult-SmallIntestine-Epithelial-Tuft-related\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	KRT74 ALDH2 DMBT1 NOTCH2	1.77e-04	195	64	4	23ab7e2a419377c05bab0e92a2457afbcd3d9e07
ToppCell	metastatic_Brain-T/NK_cells-NK\|T/NK_cells / Location, Cell class and cell subclass	KRT81 KRT86 FNIP1 PNRC1	1.77e-04	195	64	4	184471f71b8bbffec12ebb8dd6a0af589e021c02
ToppCell	5'-Adult-SmallIntestine-Epithelial-Tuft-related-BEST4+_epithelial\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	KRT74 ALDH2 DMBT1 NOTCH2	1.77e-04	195	64	4	e87b11e3242fdbed2e7f383e6876ec375af32bd4
ToppCell	Tracheal-10x3prime_v2-Epithelial-Epi_submucosal-gland-SMG_Duct\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	KRT81 KRT83 B3GNT3 DMBT1	1.77e-04	195	64	4	fdbb4abc0c79a6aeace71bfa5a5c5576ca39d758
ToppCell	AT2_cells-SSc-ILD_02\|World / lung cells shred on cell class, cell subclass, sample id	MFSD2A SLC7A2 HHIP DMBT1	1.77e-04	195	64	4	bb45a17871a8a2593bc16a95f22e3c239c49985b
ToppCell	AT2_cells-SSc-ILD_01\|World / lung cells shred on cell class, cell subclass, sample id	HSPG2 MFSD2A HHIP DMBT1	1.84e-04	197	64	4	42e49a8ce3118db6c2fd620d70c480b75143c828
ToppCell	AT2_cells-HP_01\|World / lung cells shred on cell class, cell subclass, sample id	MFSD2A SLC7A2 HHIP DMBT1	1.84e-04	197	64	4	8b5d4e1c33a57c899c51feb9a6f347232f8910a3
ToppCell	medial-2-Epithelial-Alveolar_Epithelial_Type_2\|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	MFSD2A SLC7A2 HHIP DMBT1	1.88e-04	198	64	4	102a4cbb138adbfba11ed955420095daa098532f
ToppCell	medial-Epithelial-Alveolar_Epithelial_Type_2-2\|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	MFSD2A SLC7A2 HHIP DMBT1	1.88e-04	198	64	4	7caeed2d5dc78866023c8f38edcec9886baa9f2c
ToppCell	ASK428-Epithelial-Type_2\|ASK428 / Donor, Lineage and Cell class of Lung cells from Dropseq	MFSD2A SLC7A2 HHIP DMBT1	1.88e-04	198	64	4	ec0d1801363adb70c6a26655b79d12b438c7417d
ToppCell	Parenchymal-10x3prime_v2-Stromal-Mesofibroblastic\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	IL17RC CSMD2 CRB2 BEGAIN	1.88e-04	198	64	4	0cd930e374c2c48d1991b51c025f9801b22ecee7
ToppCell	medial-Epithelial-Alveolar_Epithelial_Type_2\|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	MFSD2A SLC7A2 HHIP DMBT1	1.88e-04	198	64	4	53e5d76831d70b9a476f3ef3a81e13eda974d543
ToppCell	Parenchymal-10x3prime_v2-Stromal-Mesofibroblastic-Mesothelia\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	IL17RC CSMD2 CRB2 BEGAIN	1.88e-04	198	64	4	e0df6d6ff2a9c41d813f84a2a5ee7cb5f6fc3e30
ToppCell	PBMC_fresh-frozen-Severe-critical_convalescent_d42-56-Myeloid-Monocytic-Classical_Monocyte-Mono_c2-CD14-HLA-DPB1\|Severe-critical_convalescent_d42-56 / Compartment, severity and other cell annotations on 10x 3' data (130k)	ALDH2 MS4A7 NOTCH2 STAB1	1.92e-04	199	64	4	4fc03377c017209111561789226621d258291481
ToppCell	ASK452-Epithelial\|ASK452 / Donor, Lineage and Cell class of Lung cells from Dropseq	MFSD2A SLC7A2 HHIP DMBT1	1.92e-04	199	64	4	e8778d4d2bc7e15b4c7989a93e5808a76738df46
ToppCell	ASK454-Immune-B_cell\|ASK454 / Donor, Lineage and Cell class of Lung cells from Dropseq	HHIP ALDH2 DMBT1 MS4A7	1.92e-04	199	64	4	b9b0ae81b9e7e35023c73d3b936e88167461ba54
ToppCell	distal-2-Epithelial-Alveolar_Epithelial_Type_2\|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	MFSD2A SLC7A2 HHIP DMBT1	1.92e-04	199	64	4	21b44031bc5182ee23ba5e206042b2e5e4ee0c3c
ToppCell	control-Myeloid-CD14_Monocytes_1\|control / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	ALDH2 REEP5 MS4A7 STAB1	1.92e-04	199	64	4	8c14237c3da91d1a4878df489a495408a1e83883
ToppCell	390C-Myeloid-Monocyte-CD16+_Monocyte\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	PNRC1 REEP5 MS4A7 STAB1	1.92e-04	199	64	4	1a691dbf3da26f5450bde428a7c886dbc4834c81
ToppCell	distal-3-Epithelial-Signaling_Alveolar_Epithelial_Type_2\|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	MFSD2A SLC7A2 HHIP DMBT1	1.95e-04	200	64	4	a77087a393aad674d4aa457ca6c0077b0424053d
ToppCell	Posterior_cortex-Endothelial-ENDOTHELIAL_STALK-Flt1_1-Endothelial_Stalk.Flt1.Car4_(Car4)-\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	KRT5 B3GNT3 TUBAL3	2.41e-04	84	64	3	f7ce09c6fb2795b7aecabce00cb9830b3c1a7d0e
ToppCell	Posterior_cortex-Endothelial-ENDOTHELIAL_STALK-Flt1_1-Endothelial_Stalk.Flt1.Car4_(Car4)\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	KRT5 B3GNT3 TUBAL3	2.41e-04	84	64	3	5d5e519a6652029b9f5275c8e648bbb123fd07b9
ToppCell	Posterior_cortex-Endothelial-ENDOTHELIAL_STALK-Flt1_1-Endothelial_Stalk.Flt1.Car4_(Car4)--\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	KRT5 B3GNT3 TUBAL3	2.41e-04	84	64	3	2b477de422a9f6a8474cba05094577b88236a4f0
Drug	sulfur mustard	KRT5 KRT74 KRT81 KRT82 KRT83 KRT86 CSRP3	7.13e-08	130	63	7	CID000010461
Drug	ATBI	KRT81 KRT82 KRT83 KRT86	1.58e-07	18	63	4	CID000505862
Drug	pyriproxyfen	KRT81 KRT82 KRT83 KRT86	4.53e-07	23	63	4	CID000091753
Drug	teleocidin B	KRT5 KRT74 KRT81 KRT82 KRT83 KRT86	1.16e-06	123	63	6	CID000072425
Drug	homocysteine thiolactone	KRT5 KRT74 KRT81 KRT82 KRT83 KRT86	1.68e-06	131	63	6	CID000107712
Drug	al-Badry	KRT5 KRT74 KRT81 KRT82 KRT83 KRT86	6.39e-06	165	63	6	CID000004545
Drug	tebuquine	KRT81 KRT83	7.54e-06	2	63	2	CID000071991
Drug	3,5-di-O-galloylquinic acid	KRT81 KRT83	7.54e-06	2	63	2	CID000460896
Drug	melicopicine	KRT81 KRT83	7.54e-06	2	63	2	CID000101253
Drug	Velcade (bortezomib	KRT5 KRT74 KRT81 KRT82 KRT83 KRT86 PGGT1B KCNH4	8.66e-06	374	63	8	CID000093860
Drug	1-2q	KRT5 KRT74 KRT81 KRT82 KRT83 KRT86 ALDH2	1.49e-05	289	63	7	CID000011820
Drug	AC1L9MJT	KRT5 KRT74 KRT81 KRT82 KRT83 KRT86	1.52e-05	192	63	6	CID000448959
Drug	Remoxipride Hydrochloride [73220-03-8]; Up 200; 9.8uM; MCF7; HT_HG-U133A	SLC7A2 IL17RC HERC3 MAP3K13 B3GNT3 DMBT1	1.80e-05	198	63	6	5443_UP
Drug	sulfonamide-3	KRT81 KRT83	2.26e-05	3	63	2	CID009847197
Drug	AC1L1BIT	KRT81 KRT82 KRT83 KRT86	2.31e-05	60	63	4	CID000001457
Drug	salsalate	KRT81 KRT82 KRT83 KRT86	3.37e-05	66	63	4	CID000005161
Drug	lactucin	KRT81 KRT83	4.51e-05	4	63	2	CID000442266
Drug	Lactupicrin	KRT81 KRT83	4.51e-05	4	63	2	CID000174880
Drug	MW 1	HDAC4 KRT81 KRT82 KRT83 KRT86	6.19e-05	151	63	5	CID000073965
Drug	dihydralazine	KRT81 KRT83 ELANE	7.01e-05	29	63	3	CID000010230
Drug	n-butoxyacetaldehyde	ALDH2 ALDH9A1	7.50e-05	5	63	2	ctd:C053320
Drug	dictamnine	KRT81 KRT83	1.12e-04	6	63	2	CID000068085
Drug	skimmianine	KRT81 KRT83	1.12e-04	6	63	2	CID000006760
Drug	Potassium Chloride	SLC12A6 SLC12A5	1.12e-04	6	63	2	DB00761
Drug	arborinine	KRT81 KRT83	1.12e-04	6	63	2	CID005281832
Drug	AC1L3Y54	ELANE ALDH2 ALDH9A1	1.35e-04	36	63	3	CID000124259
Drug	FB 4	KRT82 KRT86	1.57e-04	7	63	2	CID005317328
Drug	TGQA	KRT81 KRT83	1.57e-04	7	63	2	CID000127406
Drug	PNP dimethylcarbamate	ALDH2 ALDH9A1	1.57e-04	7	63	2	CID000081656
Drug	ClOO	KRT5 ELANE	1.57e-04	7	63	2	CID005460593
Drug	3-butynal	ALDH2 ALDH9A1	1.57e-04	7	63	2	CID000142966
Drug	N1-ethylchlorpropamide	ALDH2 ALDH9A1	1.57e-04	7	63	2	CID000362592
Drug	3-butynoate	ALDH2 ALDH9A1	1.57e-04	7	63	2	CID000137547
Drug	Leucocianidol	ELANE GBE1	2.09e-04	8	63	2	CID000071629
Drug	ethylphenyl(2-formylethyl)phosphinate	ALDH2 ALDH9A1	2.09e-04	8	63	2	CID000151185
Drug	nitrefazole	ALDH2 ALDH9A1	2.09e-04	8	63	2	CID000071900
Drug	AC1L8X1L	ALDH2 ALDH9A1	2.09e-04	8	63	2	CID000409504
Drug	C04554	ALDH2 ALDH9A1	2.09e-04	8	63	2	CID000440384
Drug	AC1L370J	KRT82 KRT86	2.09e-04	8	63	2	CID000084215
Drug	desethylchloroquine	KRT81 KRT83	2.09e-04	8	63	2	CID000095478
Disease	Beaded hair	KRT81 KRT83 KRT86	7.99e-09	3	60	3	cv:C0546966
Disease	MONILETHRIX	KRT81 KRT83 KRT86	7.99e-09	3	60	3	158000
Disease	monilethrix (is_implicated_in)	KRT81 KRT83 KRT86	7.99e-09	3	60	3	DOID:0050472 (is_implicated_in)
Disease	Monilethrix	KRT81 KRT83 KRT86	3.19e-08	4	60	3	C0546966
Disease	hair disease (is_implicated_in)	KRT81 KRT86	4.07e-06	2	60	2	DOID:421 (is_implicated_in)
Disease	human papilloma virus infection, oropharynx cancer	UNC13C ALDH9A1 TMCO1	1.74e-04	53	60	3	EFO_0001668, EFO_1001931
Disease	Proteinuria	UNC13C CUBN	4.20e-04	15	60	2	HP_0000093

Protein segments in the cluster

Peptide	Gene	Start	Entry
GGSFGYTRREPLGVC	ALDH9A1	136	P49189
YNTPGFSGCLSGVRF	CNTNAP1	1201	P78357
GVGDTLTFSCFPGYR	CSMD2	1056	Q7Z408
PCSFSERYYGGAGGS	BEGAIN	441	Q9BUH8
PYGFTGTLAGAATCF	SLC7A2	251	P52569
AVSLCGGLRGAFGYR	ADAMTS15	116	Q8TE58
DPLNYFLGGCAGGLT	NDUFA11	86	Q86Y39
PGYTRTGSGLYLGHC	HSPG2	1546	P98160
GGYSCRCLPGFAGER	NOTCH2	1246	Q04721
RRASFPKYGGVDGGC	DCAF1	1056	Q9Y4B6
TPLGGYNLSARCFGY	HDAC4	941	P56524
GSFRCVCAPGYGGTR	CRB2	166	Q5IJ48
PSSGLIYAFGCGARG	HERC3	311	Q15034
IYAFGCGARGQLGTG	HERC3	316	Q15034
GLFFLCGNGVYKGFP	ERVMER34-1	296	Q9H9K5
FGRVSLAGACGVGGY	KRT5	46	P13647
PYRGISCYRGLTGGF	KRT86	31	O43790
RSCRPSCYGGYGFSG	KRTAP19-5	56	Q3LI72
GYPFLGALCFGITGS	MS4A7	86	Q9GZW8
GRLAPLGFSSRGYFG	PNRC1	16	Q12796
GTRGFPIVYCSDGFC	KCNH4	36	Q9UQ05
RVASRCGGTLPGFGY	KRT82	66	Q9NSB4
CGGTLPGFGYRLGAT	KRT82	71	Q9NSB4
PGFGYRLGATCGPSA	KRT82	76	Q9NSB4
SAGLLSGYPFQCLGF	GBA	276	P04062
GSGGFLEGLFGCLRP	MAP3K13	126	O43283
LGGAPYQVTGCALGF	MFSD2A	51	Q8NA29
GACGGFLRTGDAPVF	CUBN	1976	O60494
CGGTLYGDRGSFTSP	CUBN	3511	O60494
CSPISQGGGGFDYRL	GBE1	421	Q04446
DFGFRLGGSGPCFVL	GRID2IP	16	A4D2P6
VGGCRVFSCLGSYPG	DUSP11	11	O75319
VFSCLGSYPGIEGAG	DUSP11	16	O75319
LADLGYGCGTAAFPY	C5orf24	151	Q7Z6I8
AACGFLVGRGGYRPS	DDX51	236	Q8N8A6
FGRSLLGGYCSSYVP	FNIP1	996	Q8TF40
GFALGLPFGLSGGAY	LINC02875	111	Q86X59
PYCGGGGFLLSRFTA	B3GNT3	266	Q9Y2A9
SGFTGYVPCARFLFG	FAM166B	181	A8MTA8
INNLGGCYGGSFYRP	KRTAP7-1	61	Q8IUC3
GFRSLGYGGCGFPSL	KRTAP13-1	126	Q8IUC0
GFPSLGYGVGFCRPT	KRTAP13-1	136	Q8IUC0
GVRSLGYGSCGFPSL	KRTAP13-2	126	Q52LG2
GFPSLGYGSGFCRPT	KRTAP13-2	136	Q52LG2
GYGSGFCRPTYLASR	KRTAP13-2	141	Q52LG2
GNGSSGFRFLKYGGC	KRTAP13-4	106	Q3LI77
GFRFLKYGGCGFPSL	KRTAP13-4	111	Q3LI77
KYGGCGFPSLSYGSR	KRTAP13-4	116	Q3LI77
LGYGYSCGCGSFRRL	KRTAP19-7	21	Q3SYF9
ASFVRGGCASGLYPD	ELANE	216	P08246
CYAKNFGPTGIGFGG	CSRP3	171	P50461
RPSSNCGGFLFYASG	DMBT1	1761	Q9UGM3
GPEFGGAVGLCFYLG	SLC12A6	261	Q9UHW9
FLQGRAPGSYVGACF	IL17RC	691	Q8NAC3
PYRGISCYRGLTGGF	KRT83	36	P78385
GPEFGGAVGLCFYLG	SLC12A5	196	Q9H2X9
NRCGFRGSSYLGIPF	PGGT1B	91	P53609
LYLPTGFFSLARGGC	RUSC1	626	Q9BVN2
ACAGGFSSSVGYPGR	RHBDD1	216	Q8TEB9
AQPLYACGSYGRSLG	WRAP53	336	Q9BUR4
GGVYGSRFRFTFPGC	TMCO1	21	Q9UM00
GAGCGGSRFSLGRLY	TMEM151B	466	Q8IW70
GRTSPGQFGALGACY	FOXE1	326	O00358
CGGLQGFLIFRSFGG	TUBAL3	136	A6NHL2
FGYGASLLCNLIGFG	REEP5	51	Q00765
FSNGPLVGGFVYRGC	HHIP	486	Q96QV1
CGGGIAADRGYFIQP	ALDH2	386	P05091
GLSSLSSGFGGYFLP	TAS1R1	796	Q7RTX1
FSALQVCGGAGGGLY	UNC13C	1016	Q8NB66
GYRCPLQGLYLCGSG	PYROXD2	541	Q8N2H3
RGDGSCLCFAGYTGP	STAB1	176	Q9NY15
FPRTSGARFCGAGYL	WDR59	536	Q6PJI9
LLGGGGNCFSFGTYF	LCMT2	656	O60294
TGGGYFGLSFTCPSL	WNK3	1246	Q9BYP7
LASYCAAGRGAGAGF	KRT74	31	Q7RTS7
PYRGISCYRGLTGGF	KRT81	31	Q14533