Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	high-affinity IgG receptor activity	FCGR1A FCGR1BP	8.01e-06	2	57	2	GO:0019771
GeneOntologyMolecularFunction	leukotriene receptor binding	FCGR1A FCGR1BP	8.01e-06	2	57	2	GO:0031774
GeneOntologyMolecularFunction	IgG receptor activity	FCGR1A FCGR1BP	1.67e-04	7	57	2	GO:0019770
GeneOntologyMolecularFunction	beta-catenin binding	GRIP1 CDH20 DCHS1 EP300	3.83e-04	120	57	4	GO:0008013
GeneOntologyMolecularFunction	IgG binding	FCGR1A FCGR1BP	4.33e-04	11	57	2	GO:0019864
GeneOntologyMolecularFunction	protein kinase A binding	AKAP11 AKAP12 RYR2	6.09e-04	58	57	3	GO:0051018
GeneOntologyMolecularFunction	immunoglobulin receptor activity	FCGR1A FCGR1BP	7.13e-04	14	57	2	GO:0019763
GeneOntologyMolecularFunction	phosphatase binding	IKBKE DTNB CD300A DLG3 AKAP11	9.29e-04	264	57	5	GO:0019902
GeneOntologyMolecularFunction	protein kinase A catalytic subunit binding	AKAP11 RYR2	9.36e-04	16	57	2	GO:0034236
GeneOntologyMolecularFunction	peroxisome proliferator activated receptor binding	NCOR1 EP300	1.62e-03	21	57	2	GO:0042975
GeneOntologyMolecularFunction	protein kinase A regulatory subunit binding	AKAP11 RYR2	2.30e-03	25	57	2	GO:0034237
GeneOntologyMolecularFunction	modification-dependent protein binding	ANK3 IKBKE EP300 CBX2	2.84e-03	206	57	4	GO:0140030
GeneOntologyMolecularFunction	protein kinase binding	NRG1 PKD1 DLG3 RICTOR AKAP11 SMCR8 EP300 RYR2	3.20e-03	873	57	8	GO:0019901
GeneOntologyBiologicalProcess	cell-cell adhesion via plasma-membrane adhesion molecules	NRG1 CDH20 CRTAM PKD1 DCHS1 CLSTN1 IL1RAP	2.13e-05	313	56	7	GO:0098742
GeneOntologyBiologicalProcess	cell-cell adhesion	NRG1 CDH20 ANK3 CD300A MINK1 CRTAM PKD1 DCHS1 DLG3 CLSTN1 IL1RAP EP300	2.55e-05	1077	56	12	GO:0098609
GeneOntologyBiologicalProcess	regulation of phagocytosis, engulfment	FCGR1A FCGR1BP CD300A	3.68e-05	24	56	3	GO:0060099
GeneOntologyBiologicalProcess	regulation of membrane invagination	FCGR1A FCGR1BP CD300A	4.18e-05	25	56	3	GO:1905153
GeneOntologyBiologicalProcess	establishment or maintenance of cell polarity	ANK3 CRTAM PKD1 DLG3 RICTOR ALPK2	6.80e-05	257	56	6	GO:0007163
GeneOntologyBiologicalProcess	regulation of myeloid leukocyte mediated immunity	FCGR1A FCGR1BP CD300A FES	6.94e-05	81	56	4	GO:0002886
GeneOntologyBiologicalProcess	type III hypersensitivity	FCGR1A FCGR1BP	7.20e-05	5	56	2	GO:0001802
GeneOntologyBiologicalProcess	regulation of type III hypersensitivity	FCGR1A FCGR1BP	7.20e-05	5	56	2	GO:0001803
GeneOntologyBiologicalProcess	positive regulation of type III hypersensitivity	FCGR1A FCGR1BP	7.20e-05	5	56	2	GO:0001805
GeneOntologyBiologicalProcess	negative regulation of catabolic process	NCOR1 NRG1 SENP1 IKBKE POLDIP2 SMCR8 EP300	1.32e-04	418	56	7	GO:0009895
GeneOntologyBiologicalProcess	definitive erythrocyte differentiation	NCOR1 SENP1	2.01e-04	8	56	2	GO:0060318
GeneOntologyBiologicalProcess	response to interleukin-1	YTHDC2 IL1RAP EP300 AKAP12	2.43e-04	112	56	4	GO:0070555
GeneOntologyBiologicalProcess	positive regulation of cellular component organization	GRIP1 NRG1 FCGR1A FCGR1BP FES RICTOR KIF3C POLDIP2 CLSTN1 IL1RAP SMCR8 EP300	2.48e-04	1366	56	12	GO:0051130
GeneOntologyBiologicalProcess	positive regulation of type IIa hypersensitivity	FCGR1A FCGR1BP	3.21e-04	10	56	2	GO:0001798
GeneOntologyBiologicalProcess	positive regulation of type II hypersensitivity	FCGR1A FCGR1BP	3.21e-04	10	56	2	GO:0002894
GeneOntologyCellularComponent	GABA-ergic synapse	GRIP1 NRG1 DTNB ACAN CLSTN1	9.16e-05	164	58	5	GO:0098982
GeneOntologyCellularComponent	postsynaptic density	GRIP1 NRG1 ANK3 DTNB MINK1 DLG3 CLSTN1	2.42e-04	451	58	7	GO:0014069
GeneOntologyCellularComponent	asymmetric synapse	GRIP1 NRG1 ANK3 DTNB MINK1 DLG3 CLSTN1	3.39e-04	477	58	7	GO:0032279
GeneOntologyCellularComponent	A band	OBSCN CMYA5 RYR2	4.07e-04	52	58	3	GO:0031672
GeneOntologyCellularComponent	postsynaptic specialization	GRIP1 NRG1 ANK3 DTNB MINK1 DLG3 CLSTN1	4.66e-04	503	58	7	GO:0099572
GeneOntologyCellularComponent	neuron to neuron synapse	GRIP1 NRG1 ANK3 DTNB MINK1 DLG3 CLSTN1	5.88e-04	523	58	7	GO:0098984
MousePheno	polyhydramnios	ACAN PKD1	4.72e-05	3	56	2	MP:0004020
MousePheno	abnormal kidney collecting duct morphology	ANK3 PKD1 DCHS1 AKAP11	5.84e-05	53	56	4	MP:0004754
MousePheno	abnormal sarcoplasmic reticulum morphology	OBSCN CMYA5 RYR2	1.02e-04	23	56	3	MP:0004088
MousePheno	abnormal heart septum morphology	ATG16L1 CMIP PKD1 FES DCHS1 EP300 AKAP12 RYR2	1.45e-04	388	56	8	MP:0006113
MousePheno	decreased susceptibility to autoimmune hemolytic anemia	FCGR1A FCGR1BP	1.56e-04	5	56	2	MP:0004828
Domain	DUF4062	NWD2 TEP1	8.83e-06	2	56	2	PF13271
Domain	DUF4062	NWD2 TEP1	8.83e-06	2	56	2	IPR025139
Domain	IG	NRG1 FCGR1A FCGR1BP CD300A CRTAM OBSCN IL1RAP ALPK2	3.44e-05	421	56	8	SM00409
Domain	Ig_sub	NRG1 FCGR1A FCGR1BP CD300A CRTAM OBSCN IL1RAP ALPK2	3.44e-05	421	56	8	IPR003599
Domain	IG_LIKE	NRG1 FCGR1A FCGR1BP CD300A CRTAM OBSCN IL1RAP ALPK2	1.01e-04	491	56	8	PS50835
Domain	Ig-like_dom	NRG1 FCGR1A FCGR1BP CD300A CRTAM OBSCN IL1RAP ALPK2	1.19e-04	503	56	8	IPR007110
Domain	-	NRG1 FCGR1A FCGR1BP CD300A CRTAM OBSCN CMYA5 IL1RAP ALPK2	1.44e-04	663	56	9	2.60.40.10
Domain	Ig-like_fold	NRG1 FCGR1A FCGR1BP CD300A CRTAM OBSCN CMYA5 IL1RAP ALPK2	2.31e-04	706	56	9	IPR013783
Domain	IGc2	NRG1 FCGR1A FCGR1BP OBSCN ALPK2	6.85e-04	235	56	5	SM00408
Domain	Ig_sub2	NRG1 FCGR1A FCGR1BP OBSCN ALPK2	6.85e-04	235	56	5	IPR003598
Domain	ZZ	DTNB EP300	1.31e-03	18	56	2	PF00569
Domain	ZF_ZZ_2	DTNB EP300	1.31e-03	18	56	2	PS50135
Domain	ZF_ZZ_1	DTNB EP300	1.31e-03	18	56	2	PS01357
Domain	Znf_ZZ	DTNB EP300	1.46e-03	19	56	2	IPR000433
Domain	ZnF_ZZ	DTNB EP300	1.46e-03	19	56	2	SM00291
Domain	ig	NRG1 FCGR1A FCGR1BP OBSCN	2.52e-03	190	56	4	PF00047
Domain	Immunoglobulin	NRG1 FCGR1A FCGR1BP OBSCN	2.52e-03	190	56	4	IPR013151
Domain	ETS_DOMAIN_1	ELF2 GABPA	3.17e-03	28	56	2	PS00345
Domain	ETS_DOMAIN_2	ELF2 GABPA	3.17e-03	28	56	2	PS00346
Domain	ETS	ELF2 GABPA	3.17e-03	28	56	2	SM00413
Domain	Ets_dom	ELF2 GABPA	3.17e-03	28	56	2	IPR000418
Domain	ETS_DOMAIN_3	ELF2 GABPA	3.17e-03	28	56	2	PS50061
Domain	Ets	ELF2 GABPA	3.17e-03	28	56	2	PF00178
Domain	CADHERIN_1	CDH20 DCHS1 CLSTN1	4.74e-03	113	56	3	PS00232
Domain	Cadherin	CDH20 DCHS1 CLSTN1	4.74e-03	113	56	3	PF00028
Domain	CADHERIN_2	CDH20 DCHS1 CLSTN1	4.85e-03	114	56	3	PS50268
Domain	-	CDH20 DCHS1 CLSTN1	4.85e-03	114	56	3	2.60.40.60
Domain	CA	CDH20 DCHS1 CLSTN1	4.97e-03	115	56	3	SM00112
Domain	Cadherin-like	CDH20 DCHS1 CLSTN1	5.09e-03	116	56	3	IPR015919
Domain	Cadherin	CDH20 DCHS1 CLSTN1	5.34e-03	118	56	3	IPR002126
Pubmed	GABP transcription factor is required for development of chronic myelogenous leukemia via its control of PRKD2.	FCGR1A FCGR1BP GABPA	1.97e-06	15	58	3	23345428
Pubmed	An improved smaller biotin ligase for BioID proximity labeling.	NCOR1 SENP1 MUC19 ELF2 RYR2	2.01e-06	123	58	5	26912792
Pubmed	Single Nucleotide Polymorphisms of the High Affinity IgG Receptor FcγRI Reduce Immune Complex Binding and Downstream Effector Functions.	FCGR1A FCGR1BP	2.73e-06	2	58	2	28814603
Pubmed	Features and protective efficacy of human mAbs targeting Mycobacterium tuberculosis arabinomannan.	FCGR1A FCGR1BP	2.73e-06	2	58	2	37733444
Pubmed	Modulating IgG effector function by Fc glycan engineering.	FCGR1A FCGR1BP	2.73e-06	2	58	2	28289219
Pubmed	Amelioration of Lupus Serum-Induced Skin Inflammation in CD64-Deficient Mice.	FCGR1A FCGR1BP	2.73e-06	2	58	2	35273604
Pubmed	IgG3-mediated enhancement of the antibody response is normal in Fc gammaRI-deficient mice.	FCGR1A FCGR1BP	2.73e-06	2	58	2	16305642
Pubmed	Congenic mapping of the insulin-dependent diabetes (Idd) gene, Idd10, localizes two genes mediating the Idd10 effect and eliminates the candidate Fcgr1.	FCGR1A FCGR1BP	2.73e-06	2	58	2	9257847
Pubmed	Fcγ receptor I alpha chain (CD64) expression in macrophages is critical for the onset of meningitis by Escherichia coli K1.	FCGR1A FCGR1BP	2.73e-06	2	58	2	21124939
Pubmed	Macrophages eliminate circulating tumor cells after monoclonal antibody therapy.	FCGR1A FCGR1BP	2.73e-06	2	58	2	24430180
Pubmed	Neuregulin-1 induces acetylcholine receptor transcription in the absence of GABPalpha phosphorylation.	NRG1 GABPA	2.73e-06	2	58	2	17975830
Pubmed	Expression of modified FcγRI enables myeloid cells to elicit robust tumor-specific cytotoxicity.	FCGR1A FCGR1BP	2.73e-06	2	58	2	38885133
Pubmed	Novel Fc gamma receptor I family gene products in human mononuclear cells.	FCGR1A FCGR1BP	2.73e-06	2	58	2	1430234
Pubmed	The FcRgamma chain is not essential for induction of experimental allergic encephalomyelitis (EAE) or anti-myelin antibody-mediated exacerbation of EAE.	FCGR1A FCGR1BP	2.73e-06	2	58	2	15835266
Pubmed	Extracellular mutations of non-obese diabetic mouse FcgammaRI modify surface expression and ligand binding.	FCGR1A FCGR1BP	2.73e-06	2	58	2	8663283
Pubmed	The interaction of N-glycans in Fcγ receptor I α-chain with Escherichia coli K1 outer membrane protein A for entry into macrophages: experimental and computational analysis.	FCGR1A FCGR1BP	2.73e-06	2	58	2	25231998
Pubmed	Lentivirus-mediated knockdown of FcγRI (CD64) attenuated lupus nephritis via inhibition of NF-κB regulating NLRP3 inflammasome activation in MRL/lpr mice.	FCGR1A FCGR1BP	2.73e-06	2	58	2	30190171
Pubmed	Molecular cloning and expression of the mouse high affinity Fc receptor for IgG.	FCGR1A FCGR1BP	2.73e-06	2	58	2	2136886
Pubmed	Gene organization of the human high affinity receptor for IgG, Fc gamma RI (CD64). Characterization and evidence for a second gene.	FCGR1A FCGR1BP	2.73e-06	2	58	2	1830050
Pubmed	FcRγ deficiency improves survival in experimental sepsis by down-regulating TLR4 signaling pathway.	FCGR1A FCGR1BP	2.73e-06	2	58	2	30552619
Pubmed	Sensory Neuron Expressed FcγRI Mediates Postinflammatory Arthritis Pain in Female Mice.	FCGR1A FCGR1BP	2.73e-06	2	58	2	35833115
Pubmed	Differential gene expression modulated by the cytoplasmic domain of Fc gamma RIa (CD64) alpha-chain.	FCGR1A FCGR1BP	2.73e-06	2	58	2	15528358
Pubmed	Functional characteristics of the high affinity IgG receptor, FcγRI.	FCGR1A FCGR1BP	2.73e-06	2	58	2	21325219
Pubmed	Fc receptors and the common gamma-chain in experimental autoimmune encephalomyelitis.	FCGR1A FCGR1BP	2.73e-06	2	58	2	14991835
Pubmed	Definition of interferon gamma-response elements in a novel human Fc gamma receptor gene (Fc gamma RIb) and characterization of the gene structure.	FCGR1A FCGR1BP	2.73e-06	2	58	2	1402657
Pubmed	FcR gamma-chain is essential for both surface expression and function of human Fc gamma RI (CD64) in vivo.	FCGR1A FCGR1BP	2.73e-06	2	58	2	8611682
Pubmed	Direct targeting of genetically modified tumour cells to Fc gammaRI triggers potent tumour cytotoxicity.	FCGR1A FCGR1BP	2.73e-06	2	58	2	16409296
Pubmed	Mouse FcgammaRI: identification and functional characterization of five new alleles.	FCGR1A FCGR1BP	2.73e-06	2	58	2	10752630
Pubmed	Fcγ Receptor Type I (CD64)-Mediated Impairment of the Capacity of Dendritic Cells to Activate Specific CD8 T Cells by IgG-opsonized Friend Virus.	FCGR1A FCGR1BP	2.73e-06	2	58	2	30744065
Pubmed	Serum anti-Fcgamma receptor autoantibodies in patients with alopecia areata.	FCGR1A FCGR1BP	2.73e-06	2	58	2	17124586
Pubmed	GA-binding protein and p300 are essential components of a retinoic acid-induced enhanceosome in myeloid cells.	EP300 GABPA	2.73e-06	2	58	2	16581781
Pubmed	Neuronal FcγRI mediates acute and chronic joint pain.	FCGR1A FCGR1BP	2.73e-06	2	58	2	31211699
Pubmed	Linkage on chromosome 3 of autoimmune diabetes and defective Fc receptor for IgG in NOD mice.	FCGR1A FCGR1BP	2.73e-06	2	58	2	8480181
Pubmed	Fc Effector Function Contributes to the Activity of Human Anti-CTLA-4 Antibodies.	FCGR1A FCGR1BP	2.73e-06	2	58	2	29576375
Pubmed	Amelioration of crescentic glomerulonephritis by RhoA kinase inhibitor, Fasudil, through podocyte protection and prevention of leukocyte migration.	FCGR1A FCGR1BP	2.73e-06	2	58	2	18245810
Pubmed	Reconstitution of allogeneic hemopoietic stem cells: the essential role of FcR gamma and the TCR beta-chain-FCp33 complex.	FCGR1A FCGR1BP	2.73e-06	2	58	2	16849450
Pubmed	Biochemical characterization of murine Fc gamma RI.	FCGR1A FCGR1BP	2.73e-06	2	58	2	8478020
Pubmed	FcγR-binding affinity of monoclonal murine IgG1s carrying different N-linked Fc oligosaccharides.	FCGR1A FCGR1BP	2.73e-06	2	58	2	31554601
Pubmed	CD64 plays a key role in diabetic wound healing.	FCGR1A FCGR1BP	2.73e-06	2	58	2	38524127
Pubmed	Developmentally ordered appearance of a functional Fc gamma receptor on TCR V gamma 3 thymocytes. Evidence for stimulation-induced expression.	FCGR1A FCGR1BP	2.73e-06	2	58	2	8077658
Pubmed	The involvement of FcR mechanisms in antibody-mediated rejection.	FCGR1A FCGR1BP	2.73e-06	2	58	2	18049118
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	SENP1 ABCF1 ANK3 MINK1 NAT10 LRPAP1 RICTOR AKAP11 POLDIP2 SMCR8 LETM1 AKAP12	5.13e-06	1487	58	12	33957083
Pubmed	Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB.	NCOR1 ANK3 MINK1 DLG3 RICTOR PC SMCR8 AKAP12 RYR2	5.30e-06	777	58	9	35844135
Pubmed	Complete coding sequence, deduced primary structure, chromosomal localization, and structural analysis of murine aggrecan.	ACAN FES	8.19e-06	3	58	2	7806222
Pubmed	Neonatal Fc receptor for IgG regulates mucosal immune responses to luminal bacteria.	FCGR1A FCGR1BP	8.19e-06	3	58	2	16841095
Pubmed	Nephrotoxic nephritis is mediated by Fcgamma receptors on circulating leukocytes and not intrinsic renal cells.	FCGR1A FCGR1BP	8.19e-06	3	58	2	12427132
Pubmed	MicroRNA-127 inhibits lung inflammation by targeting IgG Fcγ receptor I.	FCGR1A FCGR1BP	8.19e-06	3	58	2	22287715
Pubmed	Tpl2 kinase regulates FcγR signaling and immune thrombocytopenia in mice.	FCGR1A FCGR1BP	8.19e-06	3	58	2	23898046
Pubmed	CMYA5 establishes cardiac dyad architecture and positioning.	CMYA5 RYR2	8.19e-06	3	58	2	35449169
Pubmed	Serine phosphorylation of FcγRI cytoplasmic domain directs lipid raft localization and interaction with protein 4.1G.	FCGR1A FCGR1BP	8.19e-06	3	58	2	22003208
Pubmed	Unique monoclonal antibodies define expression of Fc gamma RI on macrophages and mast cell lines and demonstrate heterogeneity among subcutaneous and other dendritic cells.	FCGR1A FCGR1BP	8.19e-06	3	58	2	12594281
Pubmed	Development of proteoglycan-induced arthritis is critically dependent on Fcgamma receptor type III expression.	FCGR1A FCGR1BP	8.19e-06	3	58	2	15880819
Pubmed	Expression of ERβ and its co-regulators p300 and NCoR in human transitional cell bladder cancer.	NCOR1 EP300	8.19e-06	3	58	2	21525722
Pubmed	A new mouse expressing human Fcγ receptors to better predict therapeutic efficacy of human anti-cancer antibodies.	FCGR1A FCGR1BP	8.19e-06	3	58	2	28924242
Pubmed	Fcgamma receptor-mediated induction of dendritic cell maturation and major histocompatibility complex class I-restricted antigen presentation after immune complex internalization.	FCGR1A FCGR1BP	8.19e-06	3	58	2	9892619
Pubmed	PKA compartmentalization via AKAP220 and AKAP12 contributes to endothelial barrier regulation.	AKAP11 AKAP12	8.19e-06	3	58	2	25188285
Pubmed	Residual LCMV antigen in transiently CD4+ T cell-depleted mice induces high levels of virus-specific antibodies but only limited B-cell memory.	FCGR1A FCGR1BP	8.19e-06	3	58	2	30636035
Pubmed	Cutting Edge: Drebrin-Regulated Actin Dynamics Regulate IgE-Dependent Mast Cell Activation and Allergic Responses.	FCGR1A FCGR1BP	8.19e-06	3	58	2	26056254
Pubmed	The essential role of complement in antibody-mediated resistance to Salmonella.	FCGR1A FCGR1BP	8.19e-06	3	58	2	30179254
Pubmed	The three genes of the human FCGR1 gene family encoding Fc gamma RI flank the centromere of chromosome 1 at 1p12 and 1q21.	FCGR1A FCGR1BP	8.19e-06	3	58	2	8697799
Pubmed	Transcriptional and post-transcriptional regulation of IκB-ζ upon engagement of the BCR, TLRs and FcγR.	FCGR1A FCGR1BP	8.19e-06	3	58	2	23728777
Pubmed	FcγRI mediates serum amyloid P inhibition of fibrocyte differentiation.	FCGR1A FCGR1BP	8.19e-06	3	58	2	22493081
Pubmed	FcgammaR-induced production of superoxide and inflammatory cytokines is differentially regulated by SHIP through its influence on PI3K and/or Ras/Erk pathways.	FCGR1A FCGR1BP	8.19e-06	3	58	2	16543474
Pubmed	Escherichia coli K1 induces pterin production for enhanced expression of Fcγ receptor I to invade RAW 264.7 macrophages.	FCGR1A FCGR1BP	8.19e-06	3	58	2	24161960
Pubmed	Neuregulin-1-stimulated phosphorylation of GABP in skeletal muscle cells.	NRG1 GABPA	8.19e-06	3	58	2	11318655
Pubmed	Both Fcgamma receptor I and Fcgamma receptor III mediate disease in accelerated nephrotoxic nephritis.	FCGR1A FCGR1BP	8.19e-06	3	58	2	12707052
Pubmed	FcgammaRI ligation leads to a complex with BLT1 in lipid rafts that enhances rat lung macrophage antimicrobial functions.	FCGR1A FCGR1BP	8.19e-06	3	58	2	19657115
Pubmed	Fc-optimized antibodies elicit CD8 immunity to viral respiratory infection.	FCGR1A FCGR1BP	8.19e-06	3	58	2	33032297
Pubmed	Localization of FCGR1 encoding Fcgamma receptor class I in primates: molecular evidence for two pericentric inversions during the evolution of human chromosome 1.	FCGR1A FCGR1BP	8.19e-06	3	58	2	9763663
Pubmed	C1q-Dependent Dendritic Cell Cross-Presentation of In Vivo-Formed Antigen-Antibody Complexes.	FCGR1A FCGR1BP	8.19e-06	3	58	2	28432146
Pubmed	Toxicity of an Fc-engineered anti-CD40 antibody is abrogated by intratumoral injection and results in durable antitumor immunity.	FCGR1A FCGR1BP	8.19e-06	3	58	2	30297432
Pubmed	FcgammaRI up-regulation induced by local adenoviral-mediated interferon-gamma production aggravates chondrocyte death during immune complex-mediated arthritis.	FCGR1A FCGR1BP	8.19e-06	3	58	2	12875993
Pubmed	Differential regulation of c-Jun-dependent transcription by SUMO-specific proteases.	SENP1 EP300	8.19e-06	3	58	2	15701643
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	SENP1 ZNF827 NAT10 SCAPER RICTOR YTHDC2 POLDIP2 TEP1 EP300 ZMYM3	1.43e-05	1116	58	10	31753913
Pubmed	Articular cartilage endurance and resistance to osteoarthritic changes require transcription factor Erg.	ACAN ELF2 GABPA	1.56e-05	29	58	3	26097038
Pubmed	Identification of the mouse IgG3 receptor: implications for antibody effector function at the interface between innate and adaptive immunity.	FCGR1A FCGR1BP	1.64e-05	4	58	2	9551950
Pubmed	Sumoylation of poly(ADP-ribose) polymerase 1 inhibits its acetylation and restrains transcriptional coactivator function.	SENP1 EP300	1.64e-05	4	58	2	19622798
Pubmed	Crosstalk between sumoylation and acetylation regulates p53-dependent chromatin transcription and DNA binding.	SENP1 EP300	1.64e-05	4	58	2	19339993
Pubmed	C-reactive protein-mediated suppression of nephrotoxic nephritis: role of macrophages, complement, and Fcgamma receptors.	FCGR1A FCGR1BP	1.64e-05	4	58	2	17182593
Pubmed	Signaling through mutants of the IgA receptor CD89 and consequences for Fc receptor gamma-chain interaction.	FCGR1A FCGR1BP	1.64e-05	4	58	2	16517729
Pubmed	Unveiling skin macrophage dynamics explains both tattoo persistence and strenuous removal.	FCGR1A FCGR1BP	1.64e-05	4	58	2	29511065
Pubmed	Direct association between the CREB-binding protein (CBP) and nuclear receptor corepressor (N-CoR).	NCOR1 EP300	1.64e-05	4	58	2	17073437
Pubmed	Universal vaccine based on ectodomain of matrix protein 2 of influenza A: Fc receptors and alveolar macrophages mediate protection.	FCGR1A FCGR1BP	1.64e-05	4	58	2	21169548
Pubmed	Evidence for Cd101 but not Fcgr1 as candidate for type 1 diabetes locus, Idd10.	FCGR1A FCGR1BP	1.64e-05	4	58	2	15850792
Pubmed	Human immunoglobulin G hinge regulates agonistic anti-CD40 immunostimulatory and antitumour activities through biophysical flexibility.	FCGR1A FCGR1BP	1.64e-05	4	58	2	31562320
Pubmed	Fc receptor regulation of protective immunity against Chlamydia trachomatis.	FCGR1A FCGR1BP	1.64e-05	4	58	2	11872097
Pubmed	Abolition of anti-glomerular basement membrane antibody-mediated glomerulonephritis in FcRgamma-deficient mice.	FCGR1A FCGR1BP	1.64e-05	4	58	2	10760808
Pubmed	Adenovirus-mediated human immunodeficiency virus-1 Nef expression in human monocytes/macrophages and effect of Nef on downmodulation of Fcgamma receptors and expression of monokines.	FCGR1A FCGR1BP	1.64e-05	4	58	2	9490697
Pubmed	Glycoprotein VI-dependent and -independent pathways of thrombus formation in vivo.	FCGR1A FCGR1BP	1.64e-05	4	58	2	16455953
Pubmed	Three genes for the human high affinity Fc receptor for IgG (Fc gamma RI) encode four distinct transcription products.	FCGR1A FCGR1BP	1.64e-05	4	58	2	1379234
Pubmed	A critical role for Syk protein tyrosine kinase in Fc receptor-mediated antigen presentation and induction of dendritic cell maturation.	FCGR1A FCGR1BP	1.64e-05	4	58	2	12517949
Pubmed	The high-affinity IgG receptor, FcgammaRI, plays a central role in antibody therapy of experimental melanoma.	FCGR1A FCGR1BP	1.64e-05	4	58	2	16452176
Pubmed	The mouse Fc receptor for IgG (Ly-17): molecular cloning and specificity.	FCGR1A FCGR1BP	1.64e-05	4	58	2	2957319
Pubmed	A novel natural mutation in the thyroid hormone receptor defines a dual functional domain that exchanges nuclear receptor corepressors and coactivators.	GRIP1 NCOR1	1.64e-05	4	58	2	9849963
Pubmed	Mouse immune thrombocytopenia is associated with Th1 bias and expression of activating Fcγ receptors.	FCGR1A FCGR1BP	1.64e-05	4	58	2	28028748
Pubmed	Synergy among nuclear receptor coactivators: selective requirement for protein methyltransferase and acetyltransferase activities.	GRIP1 EP300	1.64e-05	4	58	2	11997499
Pubmed	The serine/threonine kinase Akt Promotes Fc gamma receptor-mediated phagocytosis in murine macrophages through the activation of p70S6 kinase.	FCGR1A FCGR1BP	1.64e-05	4	58	2	15485887
Pubmed	Fc receptor-mediated antibody regulation of T cell immunity against intracellular pathogens.	FCGR1A FCGR1BP	1.64e-05	4	58	2	12898452
Pubmed	Postsynaptic chromatin is under neural control at the neuromuscular junction.	EP300 GABPA	1.64e-05	4	58	2	17304221
Pubmed	Markedly different pathogenicity of four immunoglobulin G isotype-switch variants of an antierythrocyte autoantibody is based on their capacity to interact in vivo with the low-affinity Fcgamma receptor III.	FCGR1A FCGR1BP	1.64e-05	4	58	2	10770797
Interaction	NUP43 interactions	NCOR1 ATG16L1 SENP1 MUC19 ELF2 RICTOR ZHX2 ZMYM3 RYR2 GABPA	7.53e-06	625	56	10	int:NUP43
Interaction	AJUBA interactions	NCOR1 ANK3 DTNB ELF2 EP300	9.82e-06	103	56	5	int:AJUBA
Interaction	FEV interactions	NCOR1 ZHX2 EP300 ZMYM3 GABPA CBX2	2.07e-05	203	56	6	int:FEV
Interaction	KLF3 interactions	NCOR1 ELF2 ZHX2 EP300 ZMYM3 GABPA	3.97e-05	228	56	6	int:KLF3
Cytoband	15q24	SCAPER ADAMTS17	3.24e-04	21	58	2	15q24
Cytoband	Xq13.1	DLG3 ZMYM3	1.70e-03	48	58	2	Xq13.1
Cytoband	15q26.1	ACAN FES	2.15e-03	54	58	2	15q26.1
Cytoband	Ensembl 112 genes in cytogenetic band chr15q26	ACAN ADAMTS17 FES	2.29e-03	206	58	3	chr15q26
GeneFamily	Zinc fingers MYND-type\|A-kinase anchoring proteins	AKAP11 CMYA5 AKAP12	5.74e-05	29	47	3	396
GeneFamily	Cadherin related	DCHS1 CLSTN1	8.77e-04	17	47	2	24
GeneFamily	Zinc fingers ZZ-type\|Lysine acetyltransferases	DTNB EP300	9.85e-04	18	47	2	91
GeneFamily	ETS transcription factor family	ELF2 GABPA	2.39e-03	28	47	2	534
GeneFamily	Hyalectan proteoglycans\|V-set domain containing\|Sushi domain containing\|C-type lectin domain containing	ACAN PKD1	5.08e-03	41	47	2	1298
GeneFamily	Blood group antigens\|CD molecules\|I-set domain containing\|Immunoglobulin like domain containing	NRG1 OBSCN ALPK2	8.44e-03	161	47	3	593
GeneFamily	Adenosine receptors\|V-set domain containing	ACAN CD300A CRTAM	8.73e-03	163	47	3	590
GeneFamily	Armadillo repeat containing\|Protein phosphatase 1 regulatory subunits	NCOR1 DLG3 AKAP11	1.16e-02	181	47	3	694
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	OBSCN MCF2	1.28e-02	66	47	2	722
GeneFamily	Immunoglobulin like domain containing	FCGR1A FCGR1BP IL1RAP	1.38e-02	193	47	3	594
ToppCell	LA-03._Atrial_Cardiomyocyte\|World / Chamber and Cluster_Paper	GRIP1 ANK3 PDE8B OBSCN CMYA5 ALPK2 RYR2	4.99e-09	188	58	7	6d249fe92d51a19da19ec14bb2262d394255d577
ToppCell	RA-03._Atrial_Cardiomyocyte\|World / Chamber and Cluster_Paper	GRIP1 ANK3 PDE8B OBSCN CMYA5 ALPK2 RYR2	6.21e-09	194	58	7	89812fb164065041357bb37a3c2d87028ec3de4e
ToppCell	RA-03._Atrial_Cardiomyocyte\|RA / Chamber and Cluster_Paper	GRIP1 ANK3 PDE8B OBSCN CMYA5 ALPK2 RYR2	6.21e-09	194	58	7	c3535f7cc0076653c72db582047cff053c322397
ToppCell	LA-03._Atrial_Cardiomyocyte\|LA / Chamber and Cluster_Paper	GRIP1 ANK3 OBSCN CMYA5 ALPK2 RYR2	1.82e-07	191	58	6	5d1b674eb7703830b7ce8bbeac3363cabd0e6ae9
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_no-steroids-Myeloid-Macrophage-macrophage,_alveolar-Macro_c6-VCAN\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	NRG1 FCGR1A FCGR1BP CD300A FES	3.17e-06	174	58	5	eaaf17a06efc09ed4752b449827b1f0f424d3dad
ToppCell	5'-Airway_Nasal-Immune_Myeloid-Myeloid_monocytic-classical_monocyte-Classical_monocytes-Classical_monocytes_L.1.2.0.1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	THEMIS2 GRIP1 NRG1 FCGR1A TEP1	3.64e-06	179	58	5	61dbfc1b9b0344c06a68142c181cd62993556a67
ToppCell	metastatic_Brain-Myeloid_cells-Pleural_Mac\|metastatic_Brain / Location, Cell class and cell subclass	THEMIS2 FCGR1A FCGR1BP CD300A FES	3.74e-06	180	58	5	7de1c8ab1152fa517c6b4830d93ff53a19fca3d7
ToppCell	COVID-19-Heart-CM_3\|Heart / Disease (COVID-19 only), tissue and cell type	ANK3 OBSCN CMYA5 ALPK2 RYR2	3.95e-06	182	58	5	287fcc3897ae08841f6f85ae6c9cef16f75b1dd1
ToppCell	390C-Lymphocytic-CD4_T-cell-Treg_cell_1\|390C / Donor, Lineage, Cell class and subclass (all cells)	IKBKE MINK1 AKAP11 ZHX2 SMCR8	4.39e-06	186	58	5	064b6047215597465bb51a8a1547ef5a226552f9
ToppCell	RV-04._Ventricular_Cardiomyocyte_I\|RV / Chamber and Cluster_Paper	ANK3 OBSCN CMYA5 ALPK2 RYR2	4.75e-06	189	58	5	9c1debd65c13d63fd4f3158917d621b44b714c26
ToppCell	facs-Heart-LA/RA-3m\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ANK3 OBSCN CMYA5 ALPK2 RYR2	4.75e-06	189	58	5	a08b2d0fa35ffa510050ecffdc68e1b79bbe1632
ToppCell	5'-Adult-SmallIntestine-Hematopoietic-Myeloid-Monocytes\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	THEMIS2 NRG1 FCGR1A CD300A IL1RAP	4.75e-06	189	58	5	984b5f21e84dd8273d8437ac2a5a9de4e9484b9a
ToppCell	facs-Heart-LA/RA\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ANK3 OBSCN CMYA5 ALPK2 RYR2	4.75e-06	189	58	5	efa913d9c16fc32166b484d92b6449e8a0c59e03
ToppCell	RV-15._Ventricular_Cardiomyocyte_III\|World / Chamber and Cluster_Paper	ANK3 OBSCN CMYA5 ALPK2 RYR2	4.75e-06	189	58	5	0a82931b5f6c0a6427ca3edd5e2235ac49099d40
ToppCell	RV-15._Ventricular_Cardiomyocyte_III\|RV / Chamber and Cluster_Paper	ANK3 OBSCN CMYA5 ALPK2 RYR2	4.87e-06	190	58	5	93c3188dfeb0b2f9889f8ae9b9c1f2f34129c99b
ToppCell	RV-06._Ventricular_Cardiomyocyte_II\|RV / Chamber and Cluster_Paper	ANK3 OBSCN CMYA5 ALPK2 RYR2	4.87e-06	190	58	5	fe8e78922c8ae928ef9a80bffd67868d5a87a091
ToppCell	droplet-Heart-4Chambers-21m-Mesenchymal-cardiomyocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ANK3 OBSCN CMYA5 ALPK2 RYR2	4.99e-06	191	58	5	c172c9e17b893b290e4aa8af5e5e4cd3e4818372
ToppCell	droplet-Heart-4Chambers-21m-Mesenchymal-atrial_cardiomyocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ANK3 OBSCN CMYA5 ALPK2 RYR2	4.99e-06	191	58	5	715f5b449b8e075959c05a5b38389df319663164
ToppCell	LV-04._Ventricular_Cardiomyocyte_I\|LV / Chamber and Cluster_Paper	ANK3 OBSCN CMYA5 ALPK2 RYR2	5.12e-06	192	58	5	ad19e2c1d36a0566c9b12ced10db78f4781c8ea6
ToppCell	COVID-19-Heart-CM_+_EC_+_Pericyte\|Heart / Disease (COVID-19 only), tissue and cell type	ANK3 OBSCN CMYA5 ALPK2 RYR2	5.25e-06	193	58	5	dd5378a1ef8eb0eda9a3aae62f3c2f3a1402bda0
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Myeloid-Macrophage-macrophage,_alveolar-Macro_c6-VCAN\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	THEMIS2 NRG1 FCGR1A FCGR1BP IL1RAP	5.25e-06	193	58	5	52f5b0fbb8ca706206c65e7edbb1ddbd380aebae
ToppCell	21-Trachea-Immune-Hematopoietic,_Macrophage\|Trachea / Age, Tissue, Lineage and Cell class	THEMIS2 FCGR1A FCGR1BP CD300A FES	5.39e-06	194	58	5	3c4ac5f91b10802990b84db3406f5e71f8ee8b74
ToppCell	COVID-19-Heart-CM_1\|Heart / Disease (COVID-19 only), tissue and cell type	ANK3 OBSCN CMYA5 ALPK2 RYR2	5.52e-06	195	58	5	f1ef50331eda8f1239dba6ea970df4eaccf032f1
ToppCell	COVID-19-Heart-CM_2\|Heart / Disease (COVID-19 only), tissue and cell type	ANK3 OBSCN CMYA5 ALPK2 RYR2	5.52e-06	195	58	5	75fc81bddb246dca3b437fb60827b1d4fe416405
ToppCell	Tracheal-NucSeq\|Tracheal / Cell types per location group and 10X technology with lineage, and cell group designations	GRIP1 ANK3 DTNB SCAPER ZHX2	6.10e-06	199	58	5	94b94b17ca18b8dc27b91da1f2ccf89e03cc7035
ToppCell	RV-03._Atrial_Cardiomyocyte\|World / Chamber and Cluster_Paper	OBSCN CMYA5 ALPK2 RYR2	1.95e-05	122	58	4	1cb1dd03b2aaedbe04f3ed907568c3b7f54767b3
ToppCell	frontal_cortex-Non-neuronal-macrophage-Macrophage-PVM_Mrc1\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	THEMIS2 FCGR1BP CD300A FES	4.15e-05	148	58	4	d3ea907f8f408e9bb97ed223a3089e403e35f911
ToppCell	Immune_cells-Monocytes\|World / Lineage and Cell class	THEMIS2 FCGR1BP CD300A TEP1	4.15e-05	148	58	4	e8037e831a6b11b06073b4e76684eb61308822f1
ToppCell	3'_v3-Lung-Lymphocytic_T_CD4-T_CD4/CD8\|Lung / Manually curated celltypes from each tissue	ANK3 ZNF827 SCAPER OBSCN	4.49e-05	151	58	4	999c11d19b61d6b130ad5e623afa83cbdfe13cdd
ToppCell	facs-Lung-EPCAM-3m-Myeloid-classical_monocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FCGR1BP CD300A FES TEP1	5.36e-05	158	58	4	ef5feb48161c339c7b71c576bdda61479d29dfac
ToppCell	facs-Lung-EPCAM-3m-Myeloid-Classical_Monocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FCGR1BP CD300A FES TEP1	5.36e-05	158	58	4	c6e64b9b3342e37d54baadae8fb7dfb5d246e4cf
ToppCell	droplet-Thymus-nan-21m-Myeloid-Macrophage\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CD300A OBSCN FES MCF2	5.77e-05	161	58	4	441ebd3c029861d833fbcf8a68fc740d9de8ef2f
ToppCell	droplet-Mammary_Gland-nan-21m-Myeloid-macrophage\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FCGR1BP CD300A FES TEP1	5.77e-05	161	58	4	787f91f906756ef570c0d02936c3cdfafb3f7454
ToppCell	droplet-Mammary_Gland-nan-21m-Myeloid\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FCGR1BP CD300A FES TEP1	5.77e-05	161	58	4	3db97af49520dc8cbafb4454d8afd9d588160e89
ToppCell	droplet-Mammary_Gland-nan-21m-Myeloid-macrophage\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FCGR1BP CD300A FES TEP1	5.77e-05	161	58	4	f1d258c81bcf0f3c52bd20aa58faa9a5fd888168
ToppCell	3'-Pediatric_IBD-SmallIntestine-Hematopoietic-T_cells-TRGV2_gdT\|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract	GRIP1 KRT86 ADAMTS17 FES	6.05e-05	163	58	4	004765e016c5658ee4a8bda4899804303064727b
ToppCell	saliva-Severe-critical_progression_d28-40-Myeloid-Granulocytic-Neutrophil-Neu_c5-GSTP1(high)OASL(low)\|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)	THEMIS2 FCGR1A FCGR1BP YTHDC2	6.05e-05	163	58	4	d005115aa1e1458b51de7eb719794617a4168608
ToppCell	droplet-Lung-21m-Hematologic-myeloid-classical_monocyte-classical_monocyte_l2-17-52\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ANK3 FCGR1BP FES DLG3	6.34e-05	165	58	4	354978d4f35154d7b2e36e94de669e045adef512
ToppCell	5'-GW_trimst-2-SmallIntestine-Hematopoietic-Myeloid-Lymphoid_DC\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	THEMIS2 MCF2 PC ALPK2	6.49e-05	166	58	4	75d719617c61409860f298ce91cbe3a0aafa0553
ToppCell	10x5'-blood-Lymphocytic_NK-NK_CD56bright_CD16-\|blood / Manually curated celltypes from each tissue	CD300A KRT86 CRTAM ADAMTS17	6.49e-05	166	58	4	ba42349a68b22e91a0340bda1ccecd6c7592392f
ToppCell	droplet-Lung-3m-Hematologic-myeloid-classical_monocyte\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	FCGR1BP CD300A FES TEP1	6.64e-05	167	58	4	d62d5dec30d006a9cc8f3bc5ccc578e10f105027
ToppCell	facs-Lung-3m-Hematologic-myeloid-classical_monocyte-classical_monocyte_l2\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	FCGR1BP CD300A FES TEP1	6.80e-05	168	58	4	ba9ddd403ee6d6af2fe56dffbd419764bfb703e4
ToppCell	droplet-Lung-3m-Hematologic-myeloid-classical_monocyte-classical_monocyte_l2\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	FCGR1BP CD300A FES TEP1	6.80e-05	168	58	4	3d8c431a3c8899383212fe6a7627889c40c5f3ef
ToppCell	facs-Lung-3m-Hematologic-myeloid-classical_monocyte\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	FCGR1BP CD300A FES TEP1	6.80e-05	168	58	4	af4c35c0d3f030cef8397c35fa498a71112bb16b
ToppCell	COVID-19-kidney-PEC\|COVID-19 / Disease (COVID-19 only), tissue and cell type	GRIP1 NRG1 ALPK2 AKAP12	6.80e-05	168	58	4	a086c306be430adf0632ba53e98cd8014d2de330
ToppCell	COVID-19-Heart-CM_+_Macrophage\|COVID-19 / Disease (COVID-19 only), tissue and cell type	OBSCN CMYA5 ALPK2 RYR2	7.12e-05	170	58	4	3f15242a1d3e4e9871d9170b2ef05842fb609c29
ToppCell	droplet-Lung-21m-Hematologic-myeloid\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	FCGR1BP CD300A FES TEP1	7.28e-05	171	58	4	22ad6de44e1d3f72a3d78d46fd26a5743a4f84a5
ToppCell	droplet-Lung-nan-18m-Myeloid-classical_monocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FCGR1BP CD300A FES TEP1	7.45e-05	172	58	4	35d09640d5b04fa0bbb1b40d4b8f97da587a5046
ToppCell	facs-Heart-Unknown-3m-Mesenchymal-atrial_myocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	OBSCN CMYA5 ALPK2 RYR2	7.45e-05	172	58	4	ee8ce9e8c9a6d3ee2be113f77743958005f4b3f0
ToppCell	droplet-Lung-nan-18m-Myeloid-Classical_Monocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FCGR1BP CD300A FES TEP1	7.45e-05	172	58	4	98cb64e2a768908105701a7a5b58f336036250fd
ToppCell	droplet-Lung-21m-Hematologic-myeloid-classical_monocyte\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	FCGR1BP CD300A FES TEP1	7.45e-05	172	58	4	a53c906539557594ef10368bc29aec4af063fd37
ToppCell	facs-BAT-Fat-3m-Myeloid-nan\|BAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FCGR1BP CD300A FES TEP1	7.45e-05	172	58	4	5f18c3f8eb8b7928901eede44c9b84b3c5efa1a9
ToppCell	facs-Heart-Unknown-3m-Mesenchymal-atrial_cardiomyocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	OBSCN CMYA5 ALPK2 RYR2	7.45e-05	172	58	4	bd468a7ea6ec832dcf6a816a1e0c03fa0f176dad
ToppCell	droplet-Lung-nan-21m-Myeloid-classical_monocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FCGR1BP CD300A FES TEP1	7.62e-05	173	58	4	9019049b1e2a24cb0bbbc620d64ef29dd18cc4c6
ToppCell	facs-Marrow-Granulocytes-18m-Myeloid-monocyte_+_promonocyte\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NRG1 FCGR1BP CD300A TEP1	7.62e-05	173	58	4	807183fc23478da9451906dacd88de4e73112e0d
ToppCell	droplet-Lung-nan-21m-Myeloid-Classical_Monocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FCGR1BP CD300A FES TEP1	7.62e-05	173	58	4	077029eecfe636a5baf5f70464e1713b3f6b4274
ToppCell	facs-Marrow-Granulocytes-18m-Myeloid-promonocyte\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NRG1 FCGR1BP CD300A TEP1	7.62e-05	173	58	4	2e683ec555dc0036875e0f5674dcc5e93ead205d
ToppCell	droplet-Lung-21m-Hematologic-myeloid-classical_monocyte-classical_monocyte_l2\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	FCGR1BP CD300A FES TEP1	7.62e-05	173	58	4	9acad7ec70f713fe3db6cef7bbe3b183bf16ae67
ToppCell	LV-11._Adipocyte\|LV / Chamber and Cluster_Paper	NWD2 PDE8B PC AKAP12	7.62e-05	173	58	4	c2d3fcb3de71015d03d14c63450853d2b03ffa71
ToppCell	5'-Adult-LymphNode-Hematopoietic-T_cells-gdT\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	DTNB CD300A KRT86 AKAP11	7.79e-05	174	58	4	ccc79febfcf588d8294ffc712338be96de8a5033
ToppCell	IPF-Lymphoid-ILC_A\|Lymphoid / Disease state, Lineage and Cell class	KRT86 CRTAM ADAMTS17 FES	7.96e-05	175	58	4	b6d1e40d9339426d778481fd67ab7cbc0f6cb5b2
ToppCell	metastatic_Brain-T/NK_cells-Exhausted_Tfh\|metastatic_Brain / Location, Cell class and cell subclass	NCOR1 KRT86 CRTAM C17orf100	7.96e-05	175	58	4	b732c6a423c28856211002107d8c611dcfb6f265
ToppCell	facs-Marrow-Granulocytes-3m-Myeloid-monocyte_+_promonocyte\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NRG1 FCGR1BP CD300A TEP1	7.96e-05	175	58	4	69b59ec58e64644deb7e07f31ef495ef4a6f6276
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-3m-Neuronal-interneuron\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DTNB CRTAM SCAPER RYR2	7.96e-05	175	58	4	65571d775d26a40e979dbf290a8e4320c0d9fb3f
ToppCell	facs-Marrow-Granulocytes-3m-Myeloid-promonocyte\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NRG1 FCGR1BP CD300A TEP1	7.96e-05	175	58	4	4f7498b5a0ed52c348a5f94bcd41d830ba7954ea
ToppCell	droplet-Lung-1m-Hematologic-myeloid-classical_monocyte-classical_monocyte_l2\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	FCGR1BP CD300A FES TEP1	8.14e-05	176	58	4	8f9d2a763b79cafe26dcbf3dba980d473a0b9873
ToppCell	COVID-19-Heart-CM_3\|COVID-19 / Disease (COVID-19 only), tissue and cell type	OBSCN CMYA5 ALPK2 RYR2	8.14e-05	176	58	4	9df7a124ebafb0087da0cda133a394275d7bed81
ToppCell	droplet-Lung-1m-Hematologic-myeloid-classical_monocyte\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	FCGR1BP CD300A FES TEP1	8.14e-05	176	58	4	3b5d12d5c22e32fbe80c3716ff14a7ae5769c165
ToppCell	LPS-IL1RA+antiTNF-Myeloid-Monocytes,_Macrophages\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	THEMIS2 NRG1 FCGR1A CD300A	8.32e-05	177	58	4	cdad5a2f672a7f07c05669bfcaf1ec74defd3de7
ToppCell	LPS-IL1RA+antiTNF-Myeloid-Monocytes,_Macrophages-Monocytes-Macrophages\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	THEMIS2 NRG1 FCGR1A CD300A	8.32e-05	177	58	4	991ae76bb615392d84aeb89886148fa42c1c649c
ToppCell	RV-11._Adipocyte\|World / Chamber and Cluster_Paper	NWD2 PDE8B PC AKAP12	8.32e-05	177	58	4	f0edf04930692418953e4f00a917257804ec0ffd
ToppCell	PND01-Immune-Immune_Myeloid-Monocytic-Macrophage\|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	FCGR1BP CD300A FES TEP1	8.32e-05	177	58	4	1e7b4c0e41649d57a2c219a3b7e693538b8b34e4
ToppCell	TCGA-Brain-Primary_Tumor-Low_Grade_Glioma\|TCGA-Brain / Sample_Type by Project: Shred V9	CDH20 SCAPER RICTOR PC	8.32e-05	177	58	4	e8ab340b20cd41554c3841fe980e078e878af35f
ToppCell	Children_(3_yrs)-Mesenchymal-pericyte_cell-D046\|Children_(3_yrs) / Lineage, Cell type, age group and donor	CDH20 PDE8B OBSCN RYR2	8.51e-05	178	58	4	185b44700f06ec58b3c09c80520502166c965fd6
ToppCell	droplet-Spleen-SPLEEN-30m-Hematologic-proerythroblast\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NRG1 FCGR1BP CD300A FES	8.51e-05	178	58	4	be8af4d85b8835a85a168639c37857dcaa6b00bf
ToppCell	RV-11._Adipocyte\|RV / Chamber and Cluster_Paper	NWD2 PDE8B PC AKAP12	8.51e-05	178	58	4	278bbea5cf8f0589f71675c7a3d00679391b5253
ToppCell	droplet-Lung-18m-Hematologic-myeloid-classical_monocyte\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	FCGR1BP CD300A FES TEP1	8.69e-05	179	58	4	66afd54428e6dcadc3e341faecfde42be4fb5905
ToppCell	LPS_only-Myeloid-Monocytes,_Macrophages-Monocytes-Macrophages\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	THEMIS2 NRG1 FCGR1A CD300A	8.69e-05	179	58	4	dc03b9045510eb1bb934329646bb92dd06890ce9
ToppCell	droplet-Lung-18m-Hematologic-myeloid-classical_monocyte-classical_monocyte_l2\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	FCGR1BP CD300A FES TEP1	8.69e-05	179	58	4	fa58fa0901eadb170e3d2facb2a3d8c5e624329a
ToppCell	LPS_only-Myeloid-Monocytes,_Macrophages\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	THEMIS2 NRG1 FCGR1A CD300A	8.69e-05	179	58	4	330c1326ba93bb8f32559ee1cc40e357cc44ad8d
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Outer_Medullary_Collecting_Duct_Principal_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	GRIP1 ANK3 MUC19 KIF3C	8.69e-05	179	58	4	d3438fed0d85d5ed5afa8ff820c45143d77b6c0d
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-3m-Neuronal-nan\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NWD2 CRTAM SCAPER RYR2	8.88e-05	180	58	4	f6a2208960d0df1500c974cc44c3c054cd7475a9
ToppCell	COVID-19-Heart-CM_+_EC_+_Pericyte\|COVID-19 / Disease (COVID-19 only), tissue and cell type	OBSCN CMYA5 ALPK2 RYR2	9.07e-05	181	58	4	719eb532453ab7cd7893726885bc75d74a10b21e
ToppCell	5'-Adult-LymphNode-Hematopoietic-Myeloid-Monocytes\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	NRG1 FCGR1A CD300A FES	9.27e-05	182	58	4	1fb9bdf2e9f0a9c230f109b471672f9c31e27c82
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Non-neuronal-Macroglial-Oligo-OPC\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CDH20 ADAMTS17 ZHX2 IL1RAP	9.27e-05	182	58	4	3cc61f5f7ad4a81eba3daf65e122880b5af3adc0
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Non-neuronal-Macroglial-Oligo-OPC-OPC_L1-6_MYT1\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CDH20 ADAMTS17 ZHX2 IL1RAP	9.27e-05	182	58	4	5d909e4b5f662905bf1be9c686bbddc3e87d2be9
ToppCell	367C-Fibroblasts-Fibroblast-D-\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	THEMIS2 FCGR1A FCGR1BP CD300A	9.47e-05	183	58	4	b12b89debc9dd6396188bc8fe44f54c01c560966
ToppCell	367C-Fibroblasts-Fibroblast-D\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	THEMIS2 FCGR1A FCGR1BP CD300A	9.47e-05	183	58	4	19cc0009f5332b6e4d4274df123eebbfc80b669a
ToppCell	5'-Adult-LymphNode-Hematopoietic-Myeloid-LYVE1+_Macrophage\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	THEMIS2 FCGR1A CD300A FES	9.67e-05	184	58	4	ba260f8a2e6e510141a6b9c458eb0040acff0352
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_C_(IT_L4_RORB)\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	NRG1 CDH20 CMYA5 IL1RAP	9.67e-05	184	58	4	6475a43201b136dcc9b113d2ca4cfa154ed9d65d
ToppCell	LV-15._Ventricular_Cardiomyocyte_III\|LV / Chamber and Cluster_Paper	ANK3 OBSCN CMYA5 RYR2	9.67e-05	184	58	4	ab7a1620c14a9d9b6be1b47c559931e345e9eef8
ToppCell	COVID-19-Heart-CM_1\|COVID-19 / Disease (COVID-19 only), tissue and cell type	OBSCN CMYA5 ALPK2 RYR2	9.67e-05	184	58	4	e737f0f14c49b07bbb04a165083ac32210bc5690
ToppCell	COVID-19-Heart-CM_2\|COVID-19 / Disease (COVID-19 only), tissue and cell type	OBSCN CMYA5 ALPK2 RYR2	9.87e-05	185	58	4	549eeb521c3985bff396ea0f202db21822efa51f
ToppCell	facs-Brain_Non-Myeloid-Cerebellum\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NRG1 NWD2 CRTAM RYR2	9.87e-05	185	58	4	c083a4974590b9ed3ecafedd3e9cdebc5047fe39
ToppCell	LV-15._Ventricular_Cardiomyocyte_III\|World / Chamber and Cluster_Paper	ANK3 OBSCN CMYA5 RYR2	9.87e-05	185	58	4	6baccb26f999145e51b91d94315bf8d4655bef31
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_C_(IT_L4_RORB)-Exc_L4_RORB_CCDC168\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	NRG1 CDH20 ZNF827 IL1RAP	9.87e-05	185	58	4	5a0340c25196453f19e424d346efbf66d2c53ac3
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_C_(IT_L4_RORB)-Exc_L3-4_RORB_RPS3P6\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	NRG1 ADAMTS17 CMYA5 IL1RAP	9.87e-05	185	58	4	10da5c2a92bfb3248d3f6f94a0933996326cf590
ToppCell	PCW_05-06-Hematologic_Myeloid-Hem_Myeloid_monocytic-im_myeloid_progenitor3_(13)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	THEMIS2 FCGR1A FCGR1BP CD300A	1.01e-04	186	58	4	6575ec6a626cdea169ffd185d47828dfaa29475d
ToppCell	368C-Myeloid-Macrophage-FABP4+_Macrophage_3\|368C / Donor, Lineage, Cell class and subclass (all cells)	THEMIS2 FCGR1A FCGR1BP CRTAM	1.01e-04	186	58	4	ddfadd43efeac3b3e6b7062590cc2b8f2f2db2ab
ToppCell	facs-Heart-Unknown-3m-Mesenchymal\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	OBSCN CMYA5 ALPK2 RYR2	1.03e-04	187	58	4	0ffb988e0da2c7205c3515eca8e9851739bff5c5
Drug	Benzonatate [104-31-4]; Down 200; 6.6uM; HL60; HT_HG-U133A	THEMIS2 IKBKE CD300A SCAPER YTHDC2 ZHX2 EP300	6.53e-07	196	58	7	1843_DN
Drug	chlorpromazine hydrochloride; Down 200; 1uM; PC3; HT_HG-U133A	NCOR1 MINK1 DLG3 ZHX2 EP300 LETM1	9.92e-06	194	58	6	1217_DN
Drug	Thiamphenicol [15318-45-3]; Up 200; 11.2uM; MCF7; HT_HG-U133A	GRIP1 ANK3 MINK1 SCAPER KIF3C AKAP12	1.02e-05	195	58	6	7033_UP
Drug	Acetylsalicylsalicylic acid [530-75-6]; Up 200; 13.4uM; PC3; HT_HG-U133A	THEMIS2 ANK3 PDE8B DTNB FES PC	1.08e-05	197	58	6	2061_UP
Drug	Cosopt	NCOR1 NRG1 SENP1 FES ELF2 EP300 GABPA	2.48e-05	341	58	7	CID000003154
Disease	peak expiratory flow	SENP1 ANK3 ACAN PKD1 SCAPER ADAMTS17 PC	5.35e-05	498	58	7	EFO_0009718
Disease	vital capacity	NCOR1 NRG1 SENP1 CMIP ACAN ADAMTS17 LRPAP1 ZHX2 PC RYR2	1.34e-04	1236	58	10	EFO_0004312
Disease	dementia (is_implicated_in)	NRG1 LRPAP1	2.47e-04	12	58	2	DOID:1307 (is_implicated_in)
Disease	Fetal Alcohol Spectrum Disorders	ANK3 GABPA	2.92e-04	13	58	2	C2985290
Disease	plasma beta-amyloid 1-42 measurement	ANK3 KRT86	2.92e-04	13	58	2	EFO_0005660
Disease	Fetal Alcohol Syndrome	ANK3 GABPA	5.07e-04	17	58	2	C0015923
Disease	Cannabis use, age at onset	CDH20 RYR2	6.36e-04	19	58	2	EFO_0004847, EFO_0007585
Disease	forced expiratory volume	NCOR1 PDE8B ACAN ADAMTS17 ZHX2 PC RYR2	8.75e-04	789	58	7	EFO_0004314
Disease	retinal degeneration (biomarker_via_orthology)	FCGR1A FCGR1BP	1.39e-03	28	58	2	DOID:8466 (biomarker_via_orthology)
Disease	multiple myeloma	GRIP1 DTNB KIF3C	1.41e-03	112	58	3	EFO_0001378
Disease	hormone measurement, thyroid stimulating hormone measurement	NRG1 PDE8B	1.49e-03	29	58	2	EFO_0004730, EFO_0004748
Disease	bipolar disorder (is_implicated_in)	NRG1 ANK3	1.49e-03	29	58	2	DOID:3312 (is_implicated_in)
Disease	Mental Retardation, X-Linked	DLG3 ZMYM3	1.49e-03	29	58	2	C1136249
Disease	urate measurement	NRG1 CMIP ZNF827 SCAPER ADAMTS17 PC REXO1	1.81e-03	895	58	7	EFO_0004531
Disease	Lung Neoplasms	NRG1 ANK3 RICTOR TEP1	1.84e-03	265	58	4	C0024121
Disease	Malignant neoplasm of lung	NRG1 ANK3 RICTOR TEP1	1.87e-03	266	58	4	C0242379

Protein segments in the cluster

Peptide	Gene	Start	Entry
VTVRVVHASDKTVEV	EP300	1321	Q09472
AVIVVSHDARLITET	ABCF1	791	Q8NE71
EAETHSVLLTAVESR	CABS1	306	Q96KC9
EDTSTVTIATEVHPA	ALPK2	1006	Q86TB3
VAEVHVSTVEERTEE	AKAP12	416	Q02952
EVIVDETSDHTEETS	ATG16L1	241	Q676U5
VVASSEIHVEVERTS	CMIP	396	Q8IY22
ETSTVRVETSSHRVE	C17orf100	21	A8MU93
SAAVVHTIVNETLES	AKAP11	876	Q9UKA4
VASVQATVELETSHI	CLSTN1	296	O94985
ETLSRTEEIHENVIS	LRPAP1	191	P30533
IRLTSEHTVETLVVA	ADAMTS17	226	Q8TE56
ESSLSVTVHESIEQL	NWD2	631	Q9ULI1
NVISSEHIVEREAET	NRG1	316	Q02297
SDVHRETTENIRVTV	POLDIP2	231	Q9Y2S7
VSVFQEETVTLHCEV	FCGR1BP	31	Q92637
TVEVTVRVADINDHA	DCHS1	126	Q96JQ0
DITIDVTINESISHS	IL1RAP	291	Q9NPH3
VTINESISHSRTEDE	IL1RAP	296	Q9NPH3
HITTISDETSEQVTR	GABPA	151	Q06546
EIRVLQSHISDTSVV	KRT86	246	O43790
ETSDILQRVVVHVFS	IKBKE	301	Q14164
HISTSQVAEIVATLE	LETM1	701	O95202
EVSSRSHAIFIITVE	KIF3C	211	O14782
TSVEESRITRAEVIT	MUC19	7156	Q7Z5P9
EHTVILAVVSRVSDD	PDE8B	206	O95263
VITNSDDHISVRATI	RICTOR	411	Q6R327
HTVSSEAVSLLEEVI	NAT10	671	Q9H0A0
LRVITAAVTVETSDH	ACAN	11	P16112
HSSTEVTVEAREVTV	OBSCN	2546	Q5VST9
TRSLIEHVFVTDVTA	CBX2	496	Q14781
EASLTNHTETITVEE	CRTAM	16	O95727
QDTTTVHISVEDVDE	CDH20	371	Q9HBT6
VSSIAEHSVLSEVEA	CMYA5	1451	Q8N3K9
DHTTEISVSRLETVI	DTNB	71	O60941
VITETRTEVVHVIRS	ANK3	2161	Q12955
VNEVDVSEVVHSRAV	DLG3	186	Q92796
EVETENVETVEASVH	ELF2	71	Q15723
EETELEHTSTVVEVC	MCF2	851	P10911
EHTSTVVEVCEAIAS	MCF2	856	P10911
VSVFQEETVTLHCEV	FCGR1A	31	P12314
HRILVASEVTTEITS	H1-9P	26	P60008
VHTETTEVVLTADPV	GRIP1	466	Q9Y3R0
RTSEISAVHIDTECV	SCAPER	366	Q9BY12
EHIEVTRIDGTIDSS	RYR2	1266	Q92736
EHVVDVVVENSASRA	PKD1	906	P98161
ITETLVSLRVHTVDD	PKD1	2646	P98161
DSVSTMVVHDVEEIT	MINK1	861	Q8N4C8
VQHTLTSVTDELAVA	FES	306	P07332
LTRVTVVDTDVHVVY	REXO1	1076	Q8N1G1
ATIARSEHEISEIID	NCOR1	371	O75376
RRHVSTAEETVQEEE	SENP1	176	Q9P0U3
AVSHRTISEDSIEVL	SMCR8	506	Q8TEV9
ATHSASIQEETEEVV	CD300A	161	Q9UGN4
VSAVAAVEEHVVSVS	TEP1	2151	Q99973
AVEEHVVSVSRDGTL	TEP1	2156	Q99973
TLEVDVEDVTASSRH	THEMIS2	226	Q5TEJ8
VHSVKLVSTDTEDIV	ZNF827	866	Q17R98
HVEGTARLVTDTAEI	ZHX2	211	Q9Y6X8
TLSTVTHVIVDEVHE	YTHDC2	306	Q9H6S0
NSRLQVEHTVTEEIT	PC	326	P11498
VEHTVTEEITDVDLV	PC	331	P11498
HIEEEETTSIATARR	ZMYM3	156	Q14202