Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctioncalcium channel regulator activity

REM1 PACSIN3 RRAD NRXN1 NOS1

1.03e-05541075GO:0005246
GeneOntologyMolecularFunctionextracellular matrix constituent conferring elasticity

LAMC1 FBLN2 FBN2

3.18e-05121073GO:0030023
GeneOntologyMolecularFunctionstructural molecule activity conferring elasticity

LAMC1 FBLN2 FBN2

5.22e-05141073GO:0097493
GeneOntologyMolecularFunctionextracellular matrix structural constituent

VTN MATN2 LAMC1 FBLN2 FBN2 PXDN MMRN2

6.92e-051881077GO:0005201
GeneOntologyMolecularFunctionlow-density lipoprotein particle receptor activity

VLDLR LRP1 SORL1

7.96e-05161073GO:0005041
GeneOntologyMolecularFunctionnitric-oxide synthase activity

NOS1 NOS3

8.50e-0531072GO:0004517
GeneOntologyMolecularFunctionscaffold protein binding

PHF6 CACNA1H PLCG2 NOS1 NOS3

1.44e-04931075GO:0097110
GeneOntologyMolecularFunctiontetrahydrobiopterin binding

NOS1 NOS3

1.69e-0441072GO:0034617
GeneOntologyMolecularFunctionlipoprotein particle receptor activity

VLDLR LRP1 SORL1

1.85e-04211073GO:0030228
GeneOntologyMolecularFunctionion channel regulator activity

REM1 PACSIN3 RRAD ANKRD36C NRXN1 NOS1

2.39e-041621076GO:0099106
GeneOntologyMolecularFunctionchannel regulator activity

REM1 PACSIN3 RRAD ANKRD36C NRXN1 NOS1

3.51e-041741076GO:0016247
GeneOntologyMolecularFunctiontransporter regulator activity

REM1 PACSIN3 RRAD ANKRD36C NRXN1 NOS1

3.84e-041771076GO:0141108
GeneOntologyMolecularFunctiontransition metal ion binding

CYLD RNF31 MYCBP2 ZNF407 LHX3 PPEF2 SKI MTPAP LIMS1 ZNF276 TRIM32 ZFHX3 RNF41 NOS1 NOS3 ALOX5

5.81e-04118910716GO:0046914
GeneOntologyMolecularFunctioncalcium ion binding

PRRG1 CACNA1E VLDLR MATN2 PPEF2 EYS FBLN2 FBN2 MEGF6 NRXN1 LRP1 NOTCH2

6.75e-0474910712GO:0005509
GeneOntologyMolecularFunctionhydroxymethyl-, formyl- and related transferase activity

SHMT1 FTCD

7.80e-0481072GO:0016742
GeneOntologyMolecularFunctionarginine binding

NOS1 NOS3

9.99e-0491072GO:0034618
GeneOntologyMolecularFunctioncargo receptor activity

VLDLR VTN LRP1 SORL1

1.13e-03851074GO:0038024
GeneOntologyMolecularFunctionsmall GTPase binding

RIN3 MYCBP2 RABGAP1 CHML ANKRD27 RNF41 SORL1

1.72e-033211077GO:0031267
GeneOntologyMolecularFunctioncadmium ion binding

NOS1 NOS3

1.81e-03121072GO:0046870
GeneOntologyBiologicalProcessaxon guidance

EPHB2 EPHB6 PLXNA3 MYCBP2 MATN2 LAMC1 LHX3 NRXN1 LRP1 NOTCH2

1.97e-0628510510GO:0007411
GeneOntologyBiologicalProcessneuron projection guidance

EPHB2 EPHB6 PLXNA3 MYCBP2 MATN2 LAMC1 LHX3 NRXN1 LRP1 NOTCH2

2.03e-0628610510GO:0097485
GeneOntologyBiologicalProcesscellular catabolic process

EPHB2 NPC1 RNF31 PACSIN3 SHMT1 FTCD ECH1 SETD2 PXDN TRIM32 CLTC LRP1 RNF41 PLCG2 GPSM1 NOS1 NOS3 RUBCN SORL1

1.66e-05125310519GO:0044248
GeneOntologyBiologicalProcessaxon development

EPHB2 EPHB6 PLXNA3 MYCBP2 USP9X MATN2 LAMC1 LHX3 NRXN1 TRIM32 LRP1 NOTCH2

1.04e-0464210512GO:0061564
GeneOntologyBiologicalProcessnegative regulation of calcium ion transport

REM1 PACSIN3 RRAD NOS1 NOS3

1.07e-04921055GO:0051926
GeneOntologyBiologicalProcesscell morphogenesis involved in neuron differentiation

EPHB2 EPHB6 PLXNA3 VLDLR MYCBP2 USP9X MATN2 LAMC1 LHX3 ANKRD27 NRXN1 LRP1 NOTCH2

1.09e-0474810513GO:0048667
GeneOntologyBiologicalProcessregulation of response to wounding

EPHB2 VTN MYLK LRP1 NOS3 ALOX5 GP5

1.23e-042171057GO:1903034
GeneOntologyBiologicalProcessresponse to wounding

EPHB2 VTN MYLK MATN2 CCM2L LRP1 SCNN1G PLCG2 NOS3 ALOX5 NOTCH2 GP5

1.33e-0465910512GO:0009611
GeneOntologyBiologicalProcessaxonogenesis

EPHB2 EPHB6 PLXNA3 MYCBP2 USP9X MATN2 LAMC1 LHX3 NRXN1 LRP1 NOTCH2

1.46e-0456610511GO:0007409
GeneOntologyBiologicalProcessregulation of wound healing

EPHB2 VTN MYLK NOS3 ALOX5 GP5

2.07e-041661056GO:0061041
GeneOntologyBiologicalProcesswound healing

EPHB2 VTN MYLK CCM2L SCNN1G PLCG2 NOS3 ALOX5 NOTCH2 GP5

2.11e-0449310510GO:0042060
GeneOntologyBiologicalProcessneuron projection morphogenesis

EPHB2 EPHB6 PLXNA3 VLDLR MYCBP2 USP9X MATN2 LAMC1 LHX3 ANKRD27 NRXN1 LRP1 NOTCH2

2.17e-0480210513GO:0048812
GeneOntologyBiologicalProcesspositive regulation of binding

EPHB6 VTN USP9X SKI LRP1 GPSM1

2.35e-041701056GO:0051099
GeneOntologyBiologicalProcessnegative regulation of monoatomic ion transport

EPHB2 REM1 PACSIN3 RRAD NOS1 NOS3

2.43e-041711056GO:0043271
GeneOntologyBiologicalProcessplasma membrane bounded cell projection morphogenesis

EPHB2 EPHB6 PLXNA3 VLDLR MYCBP2 USP9X MATN2 LAMC1 LHX3 ANKRD27 NRXN1 LRP1 NOTCH2

2.66e-0481910513GO:0120039
GeneOntologyBiologicalProcesscalcium ion transport

CACNA1E REM1 MYLK PACSIN3 RRAD CACNA1H PLCG2 NOS1 NOS3 GP5

2.72e-0450910510GO:0006816
GeneOntologyBiologicalProcesscell projection morphogenesis

EPHB2 EPHB6 PLXNA3 VLDLR MYCBP2 USP9X MATN2 LAMC1 LHX3 ANKRD27 NRXN1 LRP1 NOTCH2

2.89e-0482610513GO:0048858
GeneOntologyBiologicalProcesspositive regulation of molecular function

EPHB2 EPHB6 VLDLR VTN RNF31 USP9X SKI LIMS1 ASAP2 NRXN1 TRIM32 LRP1 RNF41 PLCG2 GPSM1 NOS1 NOS3 NOTCH2

3.04e-04143010518GO:0044093
GeneOntologyCellularComponentsarcolemma

REM1 RRAD CLTC CACNA1H NOS1 NOS3 ALOX5

5.24e-051901067GO:0042383
GeneOntologyCellularComponentprotein complex involved in cell-matrix adhesion

VTN LAMC1 MMRN2

8.18e-05171063GO:0098637
GeneOntologyCellularComponentprotein complex involved in cell adhesion

VTN LAMC1 NRXN1 MMRN2

2.29e-04591064GO:0098636
GeneOntologyCellularComponentcollagen-containing extracellular matrix

VTN MATN2 LAMC1 EYS FBLN2 FBN2 PXDN MEGF6 ADAMTS17 MMRN2

3.64e-0453010610GO:0062023
GeneOntologyCellularComponentbasement membrane

VTN MATN2 LAMC1 PXDN MMRN2

3.95e-041221065GO:0005604
GeneOntologyCellularComponentT-tubule

REM1 RRAD CLTC NOS1

7.01e-04791064GO:0030315
DomainGrowth_fac_rcpt_

EPHB2 EPHB6 VLDLR MATN2 LAMC1 EYS FBLN2 FBN2 MEGF6 LRP1 NOTCH2

1.23e-0915610511IPR009030
DomainASX_HYDROXYL

VLDLR MATN2 EYS FBLN2 FBN2 MEGF6 NRXN1 LRP1 NOTCH2

4.93e-091001059PS00010
DomainEGF-type_Asp/Asn_hydroxyl_site

VLDLR MATN2 EYS FBLN2 FBN2 MEGF6 NRXN1 LRP1 NOTCH2

8.27e-091061059IPR000152
DomainEGF_2

EPHB2 VLDLR MATN2 LAMC1 EYS FBLN2 FBN2 MEGF6 NRXN1 LRP1 NOTCH2 SORL1

3.14e-0826510512PS01186
DomainEGF

VLDLR MATN2 LAMC1 EYS FBLN2 FBN2 MEGF6 NRXN1 LRP1 NOTCH2 SORL1

8.73e-0823510511SM00181
DomainEGF-like_dom

VLDLR MATN2 LAMC1 EYS FBLN2 FBN2 MEGF6 NRXN1 LRP1 NOTCH2 SORL1

1.57e-0724910511IPR000742
DomainEGF-like_CS

VLDLR MATN2 LAMC1 EYS FBLN2 FBN2 MEGF6 NRXN1 LRP1 NOTCH2 SORL1

2.51e-0726110511IPR013032
DomainEGF_CA

VLDLR MATN2 EYS FBLN2 FBN2 MEGF6 LRP1 NOTCH2

4.32e-071221058SM00179
DomainEGF-like_Ca-bd_dom

VLDLR MATN2 EYS FBLN2 FBN2 MEGF6 LRP1 NOTCH2

4.89e-071241058IPR001881
DomainEGF_CA

VLDLR MATN2 FBLN2 FBN2 MEGF6 LRP1 NOTCH2

5.41e-07861057PF07645
DomainEGF_3

VLDLR MATN2 EYS FBLN2 FBN2 MEGF6 NRXN1 LRP1 NOTCH2 SORL1

8.34e-0723510510PS50026
DomainEGF_Ca-bd_CS

VLDLR EYS FBLN2 FBN2 MEGF6 LRP1 NOTCH2

1.23e-06971057IPR018097
DomainEGF_CA

VLDLR EYS FBLN2 FBN2 MEGF6 LRP1 NOTCH2

1.41e-06991057PS01187
DomainEGF

VLDLR MATN2 EYS MEGF6 NRXN1 LRP1 NOTCH2

7.08e-061261057PF00008
DomaincEGF

MATN2 FBLN2 FBN2 LRP1

1.28e-05261054PF12662
DomaincEGF

MATN2 FBLN2 FBN2 LRP1

1.28e-05261054IPR026823
DomainEGF_1

VLDLR LAMC1 EYS FBLN2 FBN2 MEGF6 NRXN1 LRP1 NOTCH2

1.37e-052551059PS00022
DomainhEGF

EYS FBN2 MEGF6 NOTCH2

1.74e-05281054PF12661
DomainLdl_recept_b

VLDLR LRP1 SORL1

6.01e-05141053PF00058
DomainLDLRB

VLDLR LRP1 SORL1

6.01e-05141053PS51120
Domain-

VLDLR TRIM32 LRP1 SORL1

6.67e-053910542.120.10.30
DomainLY

VLDLR LRP1 SORL1

7.48e-05151053SM00135
DomainLDLR_classB_rpt

VLDLR LRP1 SORL1

7.48e-05151053IPR000033
DomainNO_synthase

NOS1 NOS3

9.36e-0531052PF02898
DomainNOS_euk

NOS1 NOS3

9.36e-0531052IPR012144
Domain-

NOS1 NOS3

9.36e-05310523.90.340.10
DomainNOS_N

NOS1 NOS3

9.36e-0531052IPR004030
DomainNOS

NOS1 NOS3

9.36e-0531052PS60001
Domain6-blade_b-propeller_TolB-like

VLDLR TRIM32 LRP1 SORL1

1.28e-04461054IPR011042
DomainSmall_GTPase_GEM/REM/Rad

REM1 RRAD

1.86e-0441052IPR017358
DomainFAD_binding_1

NOS1 NOS3

4.63e-0461052PF00667
Domain-

NOS1 NOS3

4.63e-04610521.20.990.10
DomainFAD-binding_1

NOS1 NOS3

4.63e-0461052IPR003097
DomainNADPH_Cyt_P450_Rdtase_dom3

NOS1 NOS3

4.63e-0461052IPR023173
Domain-

EPHB2 EPHB6 MYCBP2 LAMC1

7.62e-047310542.60.120.260
DomainFlavodoxin/NO_synth

NOS1 NOS3

8.57e-0481052IPR008254
DomainFlavdoxin-like

NOS1 NOS3

8.57e-0481052IPR001094
DomainVPS9

RIN3 ANKRD27

8.57e-0481052SM00167
DomainFLAVODOXIN_LIKE

NOS1 NOS3

8.57e-0481052PS50902
DomainFlavodoxin_1

NOS1 NOS3

8.57e-0481052PF00258
DomainRAS

REM1 RRAD ERAS

9.91e-04351053PS51421
Domain-

UTP6 INTS8 CLTC TTC22 GPSM1 CDC23

1.12e-0320710561.25.40.10
DomainSmall_GTPase_Ras

REM1 RRAD ERAS

1.17e-03371053IPR020849
DomainVPS9

RIN3 ANKRD27

1.37e-03101052PS51205
Domain-

NOS1 NOS3

1.37e-031010523.40.50.360
DomainFlavoprotein-like_dom

NOS1 NOS3

1.37e-03101052IPR029039
DomainFlavoprot_Pyr_Nucl_cyt_Rdtase

NOS1 NOS3

1.37e-03101052IPR001709
DomainVDCCAlpha1

CACNA1E CACNA1H

1.37e-03101052IPR002077
DomainVPS9

RIN3 ANKRD27

1.37e-03101052PF02204
DomainVPS9

RIN3 ANKRD27

1.37e-03101052IPR003123
DomainLDLR_class-A_CS

VLDLR LRP1 SORL1

1.47e-03401053IPR023415
DomainEphrin_rec_like

EPHB2 EPHB6

1.67e-03111052PF07699
DomainGalactose-bd-like

EPHB2 EPHB6 MYCBP2 LAMC1

1.95e-03941054IPR008979
DomainOxRdtase_FAD/NAD-bd

NOS1 NOS3

1.99e-03121052IPR001433
DomainGrpE_coiled_coil

PACSIN3 TRIM32

1.99e-03121052IPR013805
DomainNAD_binding_1

NOS1 NOS3

1.99e-03121052PF00175
Domain-

HSPA4L HSPH1

1.99e-031210522.60.34.10
DomainHSP70_peptide-bd

HSPA4L HSPH1

1.99e-03121052IPR029047
DomainTPR-like_helical_dom

UTP6 INTS8 CLTC TTC22 GPSM1 CDC23

2.04e-032331056IPR011990
DomainLdl_recept_a

VLDLR LRP1 SORL1

2.06e-03451053PF00057
Domain-

VLDLR LRP1 SORL1

2.20e-034610534.10.400.10
Domain-

HSPA4L HSPH1

2.35e-031310521.20.1270.10
DomainHeat_shock_70_CS

HSPA4L HSPH1

2.35e-03131052IPR018181
DomainHSP70_C

HSPA4L HSPH1

2.35e-03131052IPR029048
DomainLDLRA_1

VLDLR LRP1 SORL1

2.49e-03481053PS01209
DomainLDrepeatLR_classA_rpt

VLDLR LRP1 SORL1

2.64e-03491053IPR002172
DomainLDLa

VLDLR LRP1 SORL1

2.64e-03491053SM00192
DomainLDLRA_2

VLDLR LRP1 SORL1

2.64e-03491053PS50068
DomainRECEPTOR_TYR_KIN_V_2

EPHB2 EPHB6

2.73e-03141052PS00791
DomainRECEPTOR_TYR_KIN_V_1

EPHB2 EPHB6

2.73e-03141052PS00790
DomainTyr_kinase_rcpt_V_CS

EPHB2 EPHB6

2.73e-03141052IPR001426
DomainEphA2_TM

EPHB2 EPHB6

2.73e-03141052PF14575
DomainEphrin_rcpt_lig-bd_dom

EPHB2 EPHB6

2.73e-03141052IPR001090
DomainEph_TM

EPHB2 EPHB6

2.73e-03141052IPR027936
DomainEPH_lbd

EPHB2 EPHB6

2.73e-03141052SM00615
DomainEphrin_lbd

EPHB2 EPHB6

2.73e-03141052PF01404
DomainTyr_kinase_ephrin_rcpt

EPHB2 EPHB6

2.73e-03141052IPR016257
DomainEPH_LBD

EPHB2 EPHB6

2.73e-03141052PS51550
DomainEMI_domain

MEGF6 MMRN2

3.57e-03161052IPR011489
DomainHSP70

HSPA4L HSPH1

3.57e-03161052PF00012
DomainHSP70_2

HSPA4L HSPH1

4.03e-03171052PS00329
DomainEMI

MEGF6 MMRN2

4.03e-03171052PS51041
DomainDUF1605

DHX40 DHX8

4.03e-03171052IPR011709
DomainHSP70_1

HSPA4L HSPH1

4.03e-03171052PS00297
DomainHSP70_3

HSPA4L HSPH1

4.03e-03171052PS01036
DomainOB_NTP_bind

DHX40 DHX8

4.03e-03171052PF07717
DomainHA2

DHX40 DHX8

4.52e-03181052SM00847
DomainHA2

DHX40 DHX8

4.52e-03181052PF04408
DomainHelicase-assoc_dom

DHX40 DHX8

4.52e-03181052IPR007502
DomainHsp_70_fam

HSPA4L HSPH1

4.52e-03181052IPR013126
DomainFd_Rdtase_FAD-bd

NOS1 NOS3

5.03e-03191052IPR017927
DomainFAD_FR

NOS1 NOS3

5.03e-03191052PS51384
DomainRiboflavin_synthase-like_b-brl

NOS1 NOS3

5.03e-03191052IPR017938
DomainRCC1

MYCBP2 NEK9

5.57e-03201052PF00415
Pubmed

Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.

MORN1 MYCBP2 MBNL1 PHF6 RABGAP1 SKI ECH1 INTS8 NEK9 ASAP2 PXDN DPP9 MEGF6 MBNL2 LRP1 RBM5 ZFHX3 CACNA1H NOTCH2

1.34e-0714891071928611215
Pubmed

Human transcription factor protein interaction networks.

CYLD SIN3B HSPA4L DIS3L USP9X DHX40 HSPH1 MBNL1 PHF6 LHX3 SKI ECH1 FBN2 ZFHX3 USP54 VDAC2 PPP6R3 SORL1

3.61e-0714291071835140242
Pubmed

Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism.

EPHB2 FOXM1 SIN3B SPOUT1 USP9X HSPH1 MBNL1 CPOX ATAD2 CCNT2 SETD2 LIMS1 CLTC RBM5 CHCHD1 VDAC2 PPP6R3

6.30e-0713271071732694731
Pubmed

Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.

UTP6 RNF31 SPOUT1 MYCBP2 DHX40 HSPH1 PHF6 ECH1 ATAD2 NEK9 MTPAP ANKRD27 TRIM32 CLTC PLCG2 NUP160 VDAC2

8.22e-0713531071729467282
Pubmed

ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.

EPHB2 NPC1 PLXNA3 MYCBP2 HSPA4L MATN2 HSPH1 LAMC1 RABGAP1 NEK9 FBN2 PXDN LRP1 NOTCH2 PPP6R3 SORL1

8.39e-0712011071635696571
Pubmed

The matrisome: in silico definition and in vivo characterization by proteomics of normal and tumor extracellular matrices.

VTN MATN2 LAMC1 FBLN2 PXDN ADAMTS17 MMRN2

9.04e-07167107722159717
Pubmed

Quantitative proteomic profiling of the extracellular matrix of pancreatic islets during the angiogenic switch and insulinoma progression.

VTN MATN2 LAMC1 FBLN2 FBN2 PXDN MEGF6

1.24e-06175107728071719
Pubmed

Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.

CYLD VLDLR RNF31 DIS3L BACH2 SKI MTPAP SETD2 FBN2 LRP1 ZFHX3 USP54 NOTCH2 CDC23 SORL1

1.72e-0611161071531753913
Pubmed

Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.

FOXM1 CYLD USP9X DHX40 BACH2 RABGAP1 SETD2 CLTC CDC23 PPP6R3 SORL1

2.10e-065881071138580884
Pubmed

HIV-1 protein Tat produces biphasic changes in NMDA-evoked increases in intracellular Ca2+ concentration via activation of Src kinase and nitric oxide signaling pathways.

LRP1 NOS1 NOS3

2.35e-069107324666322
Pubmed

Overexpression of low-density lipoprotein receptor in the brain markedly inhibits amyloid deposition and increases extracellular A beta clearance.

VLDLR LRP1 SORL1

2.35e-069107320005821
Pubmed

PDZ-domain-mediated interaction of the Eph-related receptor tyrosine kinase EphB3 and the ras-binding protein AF6 depends on the kinase activity of the receptor.

EPHB2 EPHB6 NRXN1

2.35e-06910739707552
Pubmed

A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome.

MYCBP2 LAMC1 ZNF407 RRAD NEK9 LIMS1 TRIM32 CLTC RBM5 NOTCH2

3.31e-064971071023414517
Pubmed

Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.

MYCBP2 HSPA4L USP9X SETD2 CLTC USP54 NUP160 CDC23 PPP6R3

9.19e-06440107934244565
Pubmed

Deletion of the Gamma Subunit of ENaC in Endothelial Cells Does Not Protect against Renal Ischemia Reperfusion Injury.

SCNN1G NOS3

9.38e-062107234681576
Pubmed

Differential roles of neuronal and endothelial nitric oxide synthases during carrageenan-induced inflammatory hyperalgesia.

NOS1 NOS3

9.38e-062107215350652
Pubmed

Mechanochemotransduction during cardiomyocyte contraction is mediated by localized nitric oxide signaling.

NOS1 NOS3

9.38e-062107224643800
Pubmed

Compound loss of muscleblind-like function in myotonic dystrophy.

MBNL1 MBNL2

9.38e-062107224293317
Pubmed

Intron 4 polymorphism of the endothelial nitric oxide synthase gene is associated with the development of lupus nephritis.

NOS1 NOS3

9.38e-062107215119548
Pubmed

Modulation of the myogenic response in renal blood flow autoregulation by NO depends on endothelial nitric oxide synthase (eNOS), but not neuronal or inducible NOS.

NOS1 NOS3

9.38e-062107221825026
Pubmed

Chronic NOS inhibition actuates endothelial-mesenchymal transformation.

NOS1 NOS3

9.38e-062107216963618
Pubmed

Striatal malonate lesions are attenuated in neuronal nitric oxide synthase knockout mice.

NOS1 NOS3

9.38e-06210728667023
Pubmed

nNOS and eNOS modulate cGMP formation and vascular response in contracting fast-twitch skeletal muscle.

NOS1 NOS3

9.38e-062107211015578
Pubmed

Renal cortical and medullary blood flow responses to L-NAME and ANG II in wild-type, nNOS null mutant, and eNOS null mutant mice.

NOS1 NOS3

9.38e-062107215961532
Pubmed

Optical Mapping Approaches on Muscleblind-Like Compound Knockout Mice for Understanding Mechanistic Insights Into Ventricular Arrhythmias in Myotonic Dystrophy.

MBNL1 MBNL2

9.38e-062107228416514
Pubmed

Contributions of endothelial and neuronal nitric oxide synthases to cerebrovascular responses to hyperoxia.

NOS1 NOS3

9.38e-062107214526232
Pubmed

Increased Muscleblind levels by chloroquine treatment improve myotonic dystrophy type 1 phenotypes in in vitro and in vivo models.

MBNL1 MBNL2

9.38e-062107231754023
Pubmed

Altered levels of the splicing factor muscleblind modifies cerebral cortical function in mouse models of myotonic dystrophy.

MBNL1 MBNL2

9.38e-062107229331264
Pubmed

Mbnl1 and Mbnl2 regulate brain structural integrity in mice.

MBNL1 MBNL2

9.38e-062107234848815
Pubmed

Nitric oxide synthase polymorphisms and asthma phenotypes in Chinese children.

NOS1 NOS3

9.38e-062107216238787
Pubmed

Sustained nitric oxide (NO)-releasing compound reverses dysregulated NO signal transduction in priapism.

NOS1 NOS3

9.38e-062107224076963
Pubmed

Normal development of the ipsilateral retinocollicular pathway and its disruption in double endothelial and neuronal nitric oxide synthase gene knockout mice.

NOS1 NOS3

9.38e-062107211027405
Pubmed

Neuronal nitric oxide synthase plays a key role in CNS demyelination.

NOS1 NOS3

9.38e-062107217151270
Pubmed

Transient hypoxia stimulates mitochondrial biogenesis in brain subcortex by a neuronal nitric oxide synthase-dependent mechanism.

NOS1 NOS3

9.38e-062107218305236
Pubmed

High-risk histological subtype-related FAM83A hijacked FOXM1 transcriptional regulation to promote malignant progression in lung adenocarcinoma.

FOXM1 FAM83A

9.38e-062107237904848
Pubmed

Regulation of renin gene expression in kidneys of eNOS- and nNOS-deficient mice.

NOS1 NOS3

9.38e-062107210764216
Pubmed

Repetitive hyperbaric oxygen exposures enhance sensitivity to convulsion by upregulation of eNOS and nNOS.

NOS1 NOS3

9.38e-062107218342297
Pubmed

Cysteine 99 of endothelial nitric oxide synthase (NOS-III) is critical for tetrahydrobiopterin-dependent NOS-III stability and activity.

NOS1 NOS3

9.38e-06210727488039
Pubmed

The NOS3 G894T (Glu298Asp) polymorphism is a risk factor for frontotemporal lobar degeneration.

NOS1 NOS3

9.38e-062107219087148
Pubmed

Genetic analysis of NOS isoforms using nNOS and eNOS knockout animals.

NOS1 NOS3

9.38e-06210729932431
Pubmed

Rapid cerebral ischemic preconditioning in mice deficient in endothelial and neuronal nitric oxide synthases.

NOS1 NOS3

9.38e-062107212677017
Pubmed

Experience-dependent plasticity acts via GluR1 and a novel neuronal nitric oxide synthase-dependent synaptic mechanism in adult cortex.

NOS1 NOS3

9.38e-062107221813683
Pubmed

Gender specific hippocampal whole genome transcriptome data from mice lacking the Cav2.3 R-type or Cav3.2 T-type voltage-gated calcium channel.

CACNA1E CACNA1H

9.38e-062107228393090
Pubmed

Expression, localization, and regulation of NOS in human mast cell lines: effects on leukotriene production.

NOS1 NOS3

9.38e-062107215044250
Pubmed

Cutaneous neuronal nitric oxide is specifically decreased in postural tachycardia syndrome.

NOS1 NOS3

9.38e-062107217660395
Pubmed

Endothelial Nitric Oxide Synthase Is Present in Dendritic Spines of Neurons in Primary Cultures.

NOS1 NOS3

9.38e-062107228725180
Pubmed

Reproductive function in female mice lacking the gene for endothelial nitric oxide synthase.

NOS1 NOS3

9.38e-062107210534440
Pubmed

Analysis of nitric oxide synthase gene polymorphisms in neonatal respiratory distress syndrome among the Chinese Han population.

NOS1 NOS3

9.38e-062107224602444
Pubmed

Combined loss of neuronal and endothelial nitric oxide synthase causes premature mortality and age-related hypertrophic cardiac remodeling in mice.

NOS1 NOS3

9.38e-062107212788381
Pubmed

Angiotensin II response in afferent arterioles of mice lacking either the endothelial or neuronal isoform of nitric oxide synthase.

NOS1 NOS3

9.38e-062107217959704
Pubmed

Effects of nitric oxide synthase gene knockout on neurotransmitter release in vivo.

NOS1 NOS3

9.38e-06210729692709
Pubmed

Myocardial and lymphocytic expression of eNOS and nNOS before and after heart transplantation: relationship to clinical status.

NOS1 NOS3

9.38e-062107223770231
Pubmed

Nitric oxide synthase 1 is partly compensating for nitric oxide synthase 3 deficiency in nitric oxide synthase 3 knock-out mice and is elevated in murine and human cirrhosis.

NOS1 NOS3

9.38e-062107215287858
Pubmed

Mice with gene disruption of both endothelial and neuronal nitric oxide synthase exhibit insulin resistance.

NOS1 NOS3

9.38e-062107210905473
Pubmed

Nitric oxide synthase gene polymorphisms in children with minimal change nephrotic syndrome.

NOS1 NOS3

9.38e-062107219371282
Pubmed

Nitric oxide regulates the heart by spatial confinement of nitric oxide synthase isoforms.

NOS1 NOS3

9.38e-062107211907582
Pubmed

Relative contribution of eNOS and nNOS to endothelium-dependent vasodilation in the mouse aorta.

NOS1 NOS3

9.38e-062107220624383
Pubmed

Neuronal NOS-cGMP-dependent ACh-induced relaxation in pial arterioles of endothelial NOS knockout mice.

NOS1 NOS3

9.38e-06210729486242
Pubmed

Refinement of the ipsilateral retinocollicular projection is disrupted in double endothelial and neuronal nitric oxide synthase gene knockout mice.

NOS1 NOS3

9.38e-062107210727738
Pubmed

Developmental changes in the response of murine cerebellar granule cells to nitric oxide.

NOS1 NOS3

9.38e-062107218406496
Pubmed

Diminished NO generation by injured endothelium and loss of macula densa nNOS may contribute to sustained acute kidney injury after ischemia-reperfusion.

NOS1 NOS3

9.38e-062107218971208
Pubmed

Does endothelial nitric oxide synthase gene variation play a role in the occurrence of hypertension in pregnancy?

NOS1 NOS3

9.38e-062107212908999
Pubmed

Role of nitric oxide synthase on brain GABA transaminase activity and GABA levels.

NOS1 NOS3

9.38e-062107231259693
Pubmed

Voltage-dependent anion channel-2 interaction with nitric oxide synthase enhances pulmonary artery endothelial cell nitric oxide production.

NOS3 VDAC2

9.38e-062107222842492
Pubmed

Nitric oxide contributes to vascular smooth muscle relaxation in contracting fast-twitch muscles.

NOS1 NOS3

9.38e-062107211161004
Pubmed

Neuronal and endothelial nitric oxide synthase gene knockout mice.

NOS1 NOS3

9.38e-062107210559836
Pubmed

The cerebral metabolic consequences of nitric oxide synthase deficiency: glucose utilization in endothelial and neuronal nitric oxide synthase null mice.

NOS1 NOS3

9.38e-062107210027769
Pubmed

Priapism in a Fabry disease mouse model is associated with upregulated penile nNOS and eNOS expression.

NOS1 NOS3

9.38e-062107229110178
Pubmed

Carvedilol induces biased β1 adrenergic receptor-nitric oxide synthase 3-cyclic guanylyl monophosphate signalling to promote cardiac contractility.

NOS1 NOS3

9.38e-062107232956449
Pubmed

Transcriptome-wide regulation of pre-mRNA splicing and mRNA localization by muscleblind proteins.

MBNL1 MBNL2

9.38e-062107222901804
Pubmed

Akt-dependent phosphorylation of endothelial nitric-oxide synthase mediates penile erection.

NOS1 NOS3

9.38e-062107211904450
Pubmed

Modulation by NO of acetylcholine release in the ileum of wild-type and NOS gene knockout mice.

NOS1 NOS3

9.38e-062107212381527
Pubmed

Contribution of nNOS- and eNOS-derived NO to microvascular smooth muscle NO exposure.

NOS1 NOS3

9.38e-062107215033959
Pubmed

Ubiquitin ligase and signalling hub MYCBP2 is required for efficient EPHB2 tyrosine kinase receptor function.

EPHB2 MYCBP2

9.38e-062107238289221
Pubmed

Infarct size and nitric oxide synthase in murine myocardium.

NOS1 NOS3

9.38e-062107210652188
Pubmed

Conserved developmental alternative splicing of muscleblind-like (MBNL) transcripts regulates MBNL localization and activity.

MBNL1 MBNL2

9.38e-062107220009516
Pubmed

Gastric stasis in neuronal nitric oxide synthase-deficient knockout mice.

NOS1 NOS3

9.38e-062107210982771
Pubmed

Distal Alternative Last Exons Localize mRNAs to Neural Projections.

MBNL1 MBNL2

9.38e-062107226907613
Pubmed

Regulation of brain glutamate metabolism by nitric oxide and S-nitrosylation.

NOS1 NOS3

9.38e-062107226152695
Pubmed

Alternatively spliced neuronal nitric oxide synthase mediates penile erection.

NOS1 NOS3

9.38e-062107216488973
Pubmed

The Krebs cycle and mitochondrial mass are early victims of endothelial dysfunction: proteomic approach.

NOS1 NOS3

9.38e-062107219095954
Pubmed

Neuronal nitric oxide synthase control mechanisms in the cutaneous vasculature of humans in vivo.

NOS1 NOS3

9.38e-062107218048451
Pubmed

Non-Mendelian inheritance during inbreeding of Cav3.2 and Cav2.3 deficient mice.

CACNA1E CACNA1H

9.38e-062107233009476
Pubmed

MBNL Sequestration by Toxic RNAs and RNA Misprocessing in the Myotonic Dystrophy Brain.

MBNL1 MBNL2

9.38e-062107226257173
Pubmed

Immunocytochemical distribution of nitric oxide synthase in the human seminal vesicle: a light and electron microscopical study.

NOS1 NOS3

9.38e-062107212802542
Pubmed

Oxygen seizure latency and peroxynitrite formation in mice lacking neuronal or endothelial nitric oxide synthases.

NOS1 NOS3

9.38e-062107212781920
Pubmed

Endothelial NOS and the blockade of LTP by NOS inhibitors in mice lacking neuronal NOS.

NOS1 NOS3

9.38e-06210727518615
Pubmed

Proteolytic degradation of nitric oxide synthase isoforms by calpain is modulated by the expression levels of HSP90.

NOS1 NOS3

9.38e-062107217970747
Pubmed

Physician-diagnosed asthma and acute chest syndrome: associations with NOS polymorphisms.

NOS1 NOS3

9.38e-062107217351927
Pubmed

Opposing roles of miR-294 and MBNL1/2 in shaping the gene regulatory network of embryonic stem cells.

MBNL1 MBNL2

9.38e-062107229735517
Pubmed

Establishment of patterned thalamocortical connections does not require nitric oxide synthase.

NOS1 NOS3

9.38e-06210729786989
Pubmed

Two separate Ni(2+) -sensitive voltage-gated Ca(2+) channels modulate transretinal signalling in the isolated murine retina.

CACNA1E CACNA1H

9.38e-062107221883984
Pubmed

Endothelial nitric oxide synthase is predominantly involved in angiotensin II modulation of renal vascular resistance and norepinephrine release.

NOS1 NOS3

9.38e-062107218046021
Pubmed

Aberrant alternative splicing and extracellular matrix gene expression in mouse models of myotonic dystrophy.

MBNL1 MBNL2

9.38e-062107220098426
Pubmed

Nitric oxide synthase gene polymorphisms in children with primary nocturnal enuresis: a preliminary study.

NOS1 NOS3

9.38e-062107217365914
Pubmed

NOS-I and -III gene variants are differentially associated with facets of suicidal behavior and aggression-related traits.

NOS1 NOS3

9.38e-062107217579350
Pubmed

Are myocardial eNOS and nNOS involved in the beta-adrenergic and muscarinic regulation of inotropy? A systematic investigation.

NOS1 NOS3

9.38e-062107216545353
Pubmed

A mechanoresponsive PINCH-1-Notch2 interaction regulates smooth muscle differentiation of human placental mesenchymal stem cells.

LIMS1 NOTCH2

9.38e-062107233529444
Pubmed

Neuronal nitric oxide synthase in epidermis is involved in cutaneous circulatory response to mechanical stimulation.

NOS1 NOS3

9.38e-062107219940861
Pubmed

Displacement-encoded and manganese-enhanced cardiac MRI reveal that nNOS, not eNOS, plays a dominant role in modulating contraction and calcium influx in the mammalian heart.

NOS1 NOS3

9.38e-062107222058155
InteractionIGFL3 interactions

VLDLR MYCBP2 FBN2 PXDN NOTCH2 SORL1

2.91e-06751076int:IGFL3
InteractionFOXD4L6 interactions

RNF31 FBN2 NOTCH2 PPP6R3 SORL1

6.08e-06491075int:FOXD4L6
InteractionZNF408 interactions

VLDLR USP9X FBLN2 FBN2 NOTCH2 CDC23 SORL1

1.23e-051451077int:ZNF408
InteractionANKRD36B interactions

VLDLR ANKRD36C LRP1 GAN SORL1

1.66e-05601075int:ANKRD36B
InteractionDUSP10 interactions

HSPA4L FBN2 LRP1 PPP6R3 SORL1

3.78e-05711075int:DUSP10
GeneFamilyRGK type GTPase family

REM1 RRAD

1.21e-0448221260
GeneFamilyVPS9 domain containing

RIN3 ANKRD27

8.93e-0410822928
GeneFamilyLow density lipoprotein receptors

VLDLR LRP1

1.53e-0313822634
GeneFamilyFibronectin type III domain containing|Sterile alpha motif domain containing|EPH receptors

EPHB2 EPHB6

1.78e-03148221095
GeneFamilyUbiquitin specific peptidases

CYLD USP9X USP54

2.10e-0356823366
GeneFamilyDEAH-box helicases

DHX40 DHX8

2.34e-0316822500
GeneFamilyHeat shock 70kDa proteins

HSPA4L HSPH1

2.64e-0317822583
GeneFamilyBardet-Biedl syndrome associated|BBSome

BBS9 TRIM32

4.03e-0321822980
GeneFamilyZinc fingers RANBP2-type |RNA binding motif containing

RNF31 RBM5

4.03e-032182289
GeneFamilyAnkyrin repeat domain containing

ANKRD30B ANKRD36C ANKRD27 ASAP2 NOTCH2

4.87e-03242825403
GeneFamilyFibronectin type III domain containing

EPHB2 EPHB6 MYLK SORL1

6.05e-03160824555
GeneFamilyCalcium voltage-gated channel subunits

CACNA1E CACNA1H

6.15e-0326822253
CoexpressionNABA_ECM_GLYCOPROTEINS

VTN MATN2 LAMC1 EYS FBLN2 FBN2 PXDN MMRN2

1.47e-061961078M3008
CoexpressionNABA_ECM_GLYCOPROTEINS

VTN MATN2 LAMC1 FBLN2 FBN2 PXDN MMRN2

1.38e-051911077MM17059
CoexpressionNABA_CORE_MATRISOME

VTN MATN2 LAMC1 EYS FBLN2 FBN2 PXDN MMRN2

1.76e-052751078M5884
CoexpressionHALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION

MYLK MATN2 LAMC1 FBLN2 FBN2 LRP1 NOTCH2

1.86e-052001077M5930
CoexpressionGSE33162_HDAC3_KO_VS_HDAC3_KO_4H_LPS_STIM_MACROPHAGE_UP

MYCBP2 DHX40 NEK9 CCNT2 CLTC NOTCH2 SORL1

1.86e-052001077M9041
CoexpressionKOINUMA_TARGETS_OF_SMAD2_OR_SMAD3

NPC1 RIN3 MBNL1 LAMC1 RABGAP1 ECH1 ATAD2 MBNL2 TRIM32 CLTC NOTCH2 FAM83A VDAC2

4.01e-0584310713M2356
ToppCellfacs-Brain_Non-Myeloid-Striatum-24m-Mesenchymal-brain_pericyte|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

VTN MYLK DHRS11 LAMC1 LRP1 ZFHX3 CACNA1H RUBCN

1.62e-08185107838486b69c48dc5e1c4e1488208fa8954a973eccb
ToppCellfacs-Brain_Non-Myeloid-Striatum-24m-Mesenchymal-Pericyte|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

VTN MYLK DHRS11 LAMC1 LRP1 ZFHX3 CACNA1H RUBCN

1.62e-0818510783c28b5ceba3cfdb6f7e32d5b42e03b6a81a7a658
ToppCellLA-01._Fibroblast_I|World / Chamber and Cluster_Paper

APCDD1 BACH2 LAMC1 FBLN2 PXDN LRP1 ZFHX3

3.52e-0718710774ea486991f66c29728d127171a07b81404ec0b78
ToppCellE16.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-Pericyte-Pericyte_mature|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

REM1 MATN2 RRAD LIMS1 NRXN1 ZFHX3 NOTCH2

3.91e-071901077106862ef44fcaa0971c3ba0147d13eb08015ca77
ToppCellPND03-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

RABGAP1 ASAP2 FBLN2 CCM2L MEGF6 MMRN2 NOS3

3.91e-071901077d87b9e9ca863270a9c7f61674271a6440c97d1f4
ToppCelldroplet-Limb_Muscle-MUSCLE-30m-Mesenchymal-smooth_muscle_cell|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PDE3A VTN REM1 MYLK PACSIN3 RRAD CACNA1H

3.91e-0719010771ab3f19f1ce9f58e5125135704d94655a2e330a0
ToppCellPND03-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC-AEC_mature|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

RABGAP1 ASAP2 FBLN2 CCM2L MEGF6 MMRN2 NOS3

4.20e-071921077285a9d332a1e07b94f222d4b518dd56928b9e075
ToppCellLA|World / Chamber and Cluster_Paper

CACNA1E BACH2 LAMC1 FBLN2 PXDN LRP1 ZFHX3

4.35e-071931077d4bf89437216baf489ea0239136dcedf3b6714af
ToppCellLA-02._Fibroblast_II|World / Chamber and Cluster_Paper

BACH2 LAMC1 ASAP2 FBLN2 PXDN LRP1 ZFHX3

4.66e-071951077a78b605b49acd8c9d68716266ca269dafcd910b9
ToppCellChildren_(3_yrs)-Endothelial-endothelial_cell_of_artery-D046|Children_(3_yrs) / Lineage, Cell type, age group and donor

PDE3A CCM2L ERAS MMRN2 NOS1 NOS3

2.22e-061571076275a4c6fef1fff8da2bdc48e3924ad05c5e5cfc8
ToppCell356C-Endothelial_cells-Endothelial-B_(Artery)-|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)

TRAPPC11 MATN2 CCNT2 RNF41 USP54 NOS1

3.63e-0617110766a2f88c2a62cb2f69797804e24eb1137a3e148de
ToppCell356C-Endothelial_cells-Endothelial-B_(Artery)|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)

TRAPPC11 MATN2 CCNT2 RNF41 USP54 NOS1

3.63e-0617110769be3554626408bb897d1f1c43b3ab4a92651f2e2
ToppCellfacs-Heart-RV-3m-Mesenchymal-valve_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

VTN REM1 MYLK PACSIN3 NRXN1 SORL1

5.53e-0618410769c20b50f8d6ac689d41d5440c835f9db8d04758b
ToppCellfacs-Heart-RV-3m-Mesenchymal-valve_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

VTN REM1 MYLK PACSIN3 NRXN1 SORL1

5.53e-06184107631dbe6119a3bcd266ae5e9b340c853d9ff680dce
ToppCellPCW_13-14-Mesenchymal-Mesenchymal_fibroblastic-mes_Arw_fibro_(16)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

EPHB2 PDE3A MATN2 FBLN2 FBN2 ZFHX3

5.71e-0618510767dcdc009c5681ee05dd18968f7e85c3403fe34af
ToppCellP03-Endothelial-large_vessel_endothelial_cell-endothelial_cell_of_artery|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

PDE3A ASAP2 FBLN2 MMRN2 PLCG2 NOS3

6.07e-06187107666ebe1788d51b3e17bec6cdb219f709756b4e530
ToppCellP15-Endothelial-large_vessel_endothelial_cell-endothelial_cell_of_artery|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

PDE3A FBLN2 MEGF6 MMRN2 NOS3 GP5

6.26e-06188107650b27fc12347ca16bd62333baf345c83cb422a8f
ToppCellEndothelial-endothelial_cell_of_artery|World / Lineage, Cell type, age group and donor

PDE3A CCM2L MMRN2 PLCG2 NOS1 NOS3

6.45e-061891076fdd89c71113ac99b7c800c6def8888e512ff1128
ToppCellfacs-Heart-RA-3m-Mesenchymal-valve_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

VTN REM1 MYLK LIMS1 MEGF6 NRXN1

6.65e-061901076bfbdf16d488359d7935a419c4c1823288f39c183
ToppCellfacs-Heart-RA-3m-Mesenchymal-valve_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

VTN REM1 MYLK LIMS1 MEGF6 NRXN1

6.65e-061901076eb1f8bb4d903b08e50c2dc173b06c0c79d8e316e
ToppCelldroplet-Fat-Gat-18m-Mesenchymal-Cd34+|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

VLDLR REM1 MATN2 LAMC1 FBLN2 LRP1

6.85e-0619110766cab0334f76c973880bd8d1638856f2f6e4a249a
ToppCelldroplet-Fat-Gat-18m-Mesenchymal|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

VLDLR REM1 MATN2 LAMC1 FBLN2 LRP1

6.85e-061911076850c6fff6dc795431ef534fdaa41e4ad50f7367a
ToppCelldroplet-Fat-Gat-18m-Mesenchymal-mesenchymal_stem_cell_of_adipose|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

VLDLR REM1 MATN2 LAMC1 FBLN2 LRP1

6.85e-0619110768b2b00202d3c98bccbae1b4a23713892fad0ff23
ToppCellPND01-03-samps-Mesenchymal-Matrix_fibroblast-MatrixFB-A|PND01-03-samps / Age Group, Lineage, Cell class and subclass

VLDLR REM1 MYLK LIMS1 ADAMTS17 LRP1

6.85e-061911076e7c605b56934d1383237c1f946dbccef25d91368
ToppCellP03-Endothelial-large_vessel_endothelial_cell|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

PDE3A ASAP2 FBLN2 MEGF6 MMRN2 NOS3

6.85e-061911076b680e0c35f1004be36f9f0680ae3c62952e2b607
ToppCellfacs-Brain_Non-Myeloid-Hippocampus_-18m-Mesenchymal|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PDE3A VTN MYLK RRAD ZFHX3 NOTCH2

6.85e-06191107696ff4cfbdcaec4b8568f9482d732dddd399121d3
ToppCellPND14-Mesenchymal-Mesenchymal_structural|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

VLDLR REM1 MYLK LAMC1 ADAMTS17 LRP1

7.06e-06192107625492568f9cbe097b7bb1db50d8b817c80ea87d7
ToppCellP03-Mesenchymal-mesenchymal_fibroblast-alveolar_fibroblast_Wnt2-pa|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

VLDLR REM1 MYLK ECH1 ADAMTS17 LRP1

7.06e-0619210762802fae55683345ff94a1ecf73b6fbee4f17481e
ToppCelldroplet-Limb_Muscle-nan-18m-Mesenchymal-smooth_muscle_cell|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

VTN REM1 MYLK PACSIN3 RRAD CACNA1H

7.06e-06192107688472b99970ba0decbf87164fc241a1c77b3b389
ToppCellPND14-Mesenchymal-Mesenchymal_structural-Fibroblastic|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

VLDLR REM1 MYLK LAMC1 ADAMTS17 LRP1

7.06e-061921076de9c1536d5aee86f9c62acbc54ca8fa581c00f17
ToppCellP03-Mesenchymal-mesenchymal_fibroblast|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

VLDLR REM1 MYLK ECH1 ADAMTS17 LRP1

7.06e-061921076e79f2253e084a9ab9afcaf7ec42a5012ade42d36
ToppCelldroplet-Limb_Muscle-nan-24m-Mesenchymal-smooth_muscle_cell|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

VTN REM1 MYLK PACSIN3 RRAD CACNA1H

7.27e-061931076b9e11cd0896c0868aab7faec4ab7ab4d4e4d1b47
ToppCellPND03-Endothelial-Endothelial_blood-vessel-Macrovascular_EC|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ASAP2 FBLN2 CCM2L MEGF6 MMRN2 NOS3

7.27e-06193107658c590dd6f21bc7ae58ae1729dd574c0f1069592
ToppCelldroplet-Fat-BAT+GAT+MAT-30m-Mesenchymal-nan|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

VLDLR REM1 MATN2 LAMC1 FBLN2 LRP1

7.49e-061941076da926441053b499cb5107ccb116fb1b3844d82b7
ToppCelldroplet-Fat-BAT+GAT+MAT-30m-Mesenchymal|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

VLDLR REM1 MATN2 LAMC1 FBLN2 LRP1

7.49e-06194107654a7f693966b5c02f6b248950ddb5fa32af3ae67
ToppCellfacs-Brain_Non-Myeloid-Hippocampus_-18m-Mesenchymal-Pericyte|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PDE3A VTN MYLK RRAD ZFHX3 NOTCH2

7.49e-0619410763bff2e4eb16719ab7419b2f94c9c6e7302aa6629
ToppCelldroplet-Fat-BAT+GAT+MAT-30m-Mesenchymal-mesenchymal_stem_cell_of_adipose|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

VLDLR REM1 MATN2 LAMC1 FBLN2 LRP1

7.49e-061941076f34b3bbdebf56f66ff499e390e5515a4a4093f90
ToppCellLA-02._Fibroblast_II|LA / Chamber and Cluster_Paper

BACH2 LAMC1 ASAP2 FBLN2 LRP1 ZFHX3

7.49e-061941076234d1494c114cce77c619708bbcd8d5ce805f19b
ToppCellfacs-Brain_Non-Myeloid-Hippocampus_-18m-Mesenchymal-brain_pericyte|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PDE3A VTN MYLK RRAD ZFHX3 NOTCH2

7.49e-061941076fdaf61cbe7f77ff5358d150b38adb1fe3778e961
ToppCellPND14-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF1|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

VLDLR REM1 MYLK LAMC1 ADAMTS17 LRP1

7.71e-0619510763a0cad69cfc150a27a0666f612f5294c817197d7
ToppCellCOVID-19-Heart-Fib_1|Heart / Disease (COVID-19 only), tissue and cell type

APCDD1 LAMC1 FBLN2 PXDN LRP1 NOTCH2

7.71e-061951076f423baa36ac7cdc383c033e35a7d17e6bf913323
ToppCellPND14-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF1-AF1_mature|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

VLDLR REM1 MYLK LAMC1 ADAMTS17 LRP1

7.71e-0619510762b8ee7990267bb52b7e6ae03f509ffebf8908122
ToppCelldroplet-Limb_Muscle-MUSCLE-1m|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MATN2 LAMC1 SKI FBN2 PXDN MBNL2

7.71e-061951076fee9d13f48149cd5f921cfe4b8b3053cf6a6dbd2
ToppCellP03-Mesenchymal|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

VLDLR REM1 MYLK ECH1 ADAMTS17 LRP1

7.71e-0619510766180309c6ae278b996fd98c57461cbc129c028ba
ToppCellkidney_cells-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

APCDD1 MATN2 FBLN2 CCM2L MMRN2 NOS3

7.94e-061961076a20a56d8997d6db2a10046c8801c619a379de83c
ToppCellsevere-unassigned|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

FOXM1 CACNA1E MYLK DIS3L ATAD2 PLCG2

8.17e-06197107670704b149b2820b8601d2495b7cd9cbe91eda262
ToppCellAdult-Mesenchymal|Adult / Lineage, Cell type, age group and donor

PDE3A MYLK BACH2 LAMC1 FBLN2 GPSM1

8.41e-06198107626e55b409db2a1637c95fae7c54b0abea1ef550c
ToppCellParenchymal-NucSeq-Endothelial-Endothelia_vascular-VE_pulmonary_arterial|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

PDE3A FBLN2 CCM2L MMRN2 NOS1 NOS3

8.41e-061981076002424b24dacac553e02d0f764a6e8a1e567b9df
ToppCellSkin-Mesangial|Skin / Skin and Kidney Cells in Lupus Nephritis Patients.

CACNA1E PDE3A REM1 MYLK RRAD NOS3

8.66e-061991076bcb78838a91cc7828680fb413fbacdb091c5fac0
ToppCellBrain_organoid-organoid_Paulsen_bioRxiv-1_mon-Proliferating-Cycling_Progenitors|1_mon / Sample Type, Dataset, Time_group, and Cell type.

TRAPPC11 USP9X BACH2 LIMS1 PXDN NOTCH2

8.66e-061991076358c4b3037f59378db8916a2fbe9ed4830cf1449
ToppCellParenchyma_COVID-19-Stromal-TX-Smooth_muscle-1|Parenchyma_COVID-19 / Sample group, Lineage and Cell type

PDE3A REM1 MYLK RRAD PXDN CACNA1H

8.91e-06200107678e9a40153d7ba5d9ea6393a37d26fc5c0220867
ToppCellLung_Parenchyma-Severe-Mesenchymal-Mesenchymal-Smooth_muscle-1|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)

PDE3A REM1 MYLK RRAD PXDN CACNA1H

8.91e-062001076c46e06b4f22d3456e67bc62a9ac198e8041965ad
ToppCellLung_Parenchyma-Severe-Mesenchymal-Mesenchymal-Smooth_muscle-1-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

PDE3A REM1 MYLK RRAD PXDN CACNA1H

8.91e-06200107643b76e382b38b9856c07557a75e5b1ce0cee1d9e
ToppCellParenchymal-10x3prime_v2-Stromal-Fibroblastic-Fibro_peribronchial|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

APCDD1 MATN2 LAMC1 FBLN2 ADAMTS17 LRP1

8.91e-062001076efdf7066b7dd43e35dbc0d2719b75f250cf54af2
ToppCellFrontal_cortex-Endothelial-MURAL-M1(Rgs5Acta2)|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

PDE3A VTN REM1 MYLK RRAD

3.22e-051511075527059e47e381b2f6d63c1abb39bc0795ee3829d
ToppCellFrontal_cortex-Endothelial-MURAL|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

PDE3A VTN REM1 MYLK RRAD

3.22e-0515110757570372a315bc312ff57bb5f483375c401ae8787
ToppCellP07-Mesenchymal-developing_mesenchymal_cell-mesenchymal_immature_unknown_1|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

VLDLR REM1 LIMS1 MBNL2 ADAMTS17

4.37e-051611075b19f82dd98a3064581793711bb70373f18abecd9
ToppCellTCGA-Brain-Primary_Tumor-Low_Grade_Glioma-Astrocytoma|TCGA-Brain / Sample_Type by Project: Shred V9

ECH1 ANKRD27 GAN NOTCH2 SORL1

4.50e-051621075810881210e015c788814e4fe8d7a24c929cf2621
ToppCellFetal_29-31_weeks-Endothelial-endothelial_cell_of_artery-D150|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

FBLN2 CCM2L MMRN2 NOS1 NOS3

4.50e-05162107525bb1b9709f960fdf90faff56e874f52a8f5d17e
ToppCell368C-Myeloid-Macrophage-FABP4+_Macrophage_2|Macrophage / Donor, Lineage, Cell class and subclass (all cells)

PDE3A REM1 RNF31 BACH2 FBN2

4.91e-0516510753d2acdae0dd2b79a15f74158e8e566ce22b4218e
ToppCellPND14-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

RABGAP1 FBLN2 CCM2L MMRN2 NOS3

5.05e-0516610757a45785a40b7425f97be67bab1c5ceb69b2bd85a
ToppCellPND14-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC-AEC_mature|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

RABGAP1 FBLN2 CCM2L MMRN2 NOS3

5.05e-051661075bbd382812f8a84a5d99888de2d7cca3a8b5e4695
ToppCellE18.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-Pericyte-Pericyte_prolif|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

RRAD ATAD2 LIMS1 NRXN1 GPSM1

5.20e-051671075b0eb7a40491dd2432f5282f578ce569df86d21a7
ToppCellPosterior_cortex-Endothelial-MURAL|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

PDE3A VTN REM1 MYLK RRAD

5.50e-0516910750ae65daf092396b71f790b65c7a2feed90397417
ToppCellPosterior_cortex-Endothelial-MURAL-M1(Rgs5Acta2)|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

PDE3A VTN REM1 MYLK RRAD

5.50e-0516910758cd70ce27b1cecb83f8a376230e7ef41b079b124
ToppCell368C-Myeloid-Macrophage-FABP4+_Macrophage_2|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

PDE3A REM1 APCDD1 BACH2 DBR1

5.81e-051711075e59afa0a773dca3b9c208d17510ea55703b42598
ToppCell3'_v3-lymph-node_spleen-Lymphocytic_T_CD4-T_CD4/CD8|lymph-node_spleen / Manually curated celltypes from each tissue

CYLD HSPH1 MBNL1 ZNF407 ANKRD36C

5.81e-0517110752e9a20f8980b78325c52065a9c14ab3656267c05
ToppCellChildren_(3_yrs)-Endothelial-endothelial_cell_of_artery-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

PDE3A CCM2L PLCG2 NOS1 NOS3

5.81e-0517110751597459c971d6befa991d59dc66b41b6a522f797
ToppCell10x5'-lymph-node_spleen-Hematopoietic_Erythro-Mega|lymph-node_spleen / Manually curated celltypes from each tissue

PDE3A MYLK ASAP2 PKLR FAM83A

6.49e-0517510755ca3369ce2c2bb88ba097260195aecd67cec1a3a
ToppCellwk_20-22-Endothelial-Blood_vessel_endothelial-OMD+_endo|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

PDE3A FBLN2 FBN2 MMRN2 NOS1

6.66e-05176107552af8f717dbd3b59eeb868b8b7b256a8f3e57d7a
ToppCelldroplet-Lung-LUNG-1m-Lymphocytic-plasma_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PLXNA3 NUGGC SHMT1 BBS9 CACNA1H

6.84e-051771075c6812679aa6522d03bd29144e71c5fae6a92325e
ToppCelldroplet-Lung-LUNG-1m-Lymphocytic-Plasma_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PLXNA3 NUGGC SHMT1 BBS9 CACNA1H

6.84e-051771075ff97398d2adb83063b7c53a264bfae86ea7ea304
ToppCellPCW_13-14-Endothelial-Endothelial_mature-endo_arterial_(9)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

EYS CCM2L MMRN2 PLCG2 NOS1

7.03e-051781075c227da59dc7beb73f84405bf13356bdeb59d9338
ToppCelldroplet-Lung-LUNG-30m-Endothelial-Artery_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PDE3A FBLN2 MEGF6 MMRN2 NOS3

7.22e-051791075a09647750eba9d93c5efc1db3b555fefb5eec7b5
ToppCell3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.0.5|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

HSPH1 ANKRD36C PLCG2 USP54 SORL1

7.22e-0517910756e965e424eebef50f0202cff75f458be395cfca1
ToppCellwk_15-18-Endothelial-Blood_vessel_endothelial-OMD+_endo|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

PDE3A FBLN2 FBN2 MMRN2 NOS1

7.22e-0517910758c9ed247e1c4d655b81ce2f24a9936a7cade718a
ToppCellPND03-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-Pericyte-Pericyte_mature|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

VTN MYLK RRAD LIMS1 NRXN1

7.22e-05179107556db12467b445f2b8ef92af50779eeab10413eb2
ToppCellfacs-Lung-24m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell-pulmonary_artery_endothelial_cell_l25|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ATAD2 FBLN2 FBN2 MMRN2 NUP160

7.41e-051801075baa5825e6ce23a98d9c21d024a4b0ab8ba353d0c
ToppCellAT1-AT2_cells-SSc-ILD_01|World / lung cells shred on cell class, cell subclass, sample id

EPHB2 BACH2 FBN2 PXDN CACNA1H

7.41e-0518010753c7b2033821f9e34e2924bd8655f566edcbcc7d3
ToppCellfacs-Lung-24m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ATAD2 FBLN2 FBN2 MMRN2 NUP160

7.41e-0518010752d608b9394d28d19cfc85c6ac94003d5177c8a92
ToppCellfacs-Lung-24m-Endothelial-arterial_endothelial|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ATAD2 FBLN2 FBN2 MMRN2 NUP160

7.41e-0518010750f9b27054358c4737eed06c8ea01987cccc3cb55
ToppCellE18.5-samps-Mesenchymal-Matrix_fibroblast|E18.5-samps / Age Group, Lineage, Cell class and subclass

VLDLR REM1 MYLK ADAMTS17 LRP1

7.81e-051821075ceb37c214662a48efb56ab0d015977c6fab478b0
ToppCellCerebellum-Endothelial-MURAL-M1(Rgs5Acta2)|Cerebellum / BrainAtlas - Mouse McCarroll V32

PDE3A VTN REM1 MYLK RRAD

7.81e-051821075da61e7cb2537c567968d8bd8baf537ecdff0ab18
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L1-3_VIP_ZNF322P1|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

PDE3A PLSCR5 PXDN ADAMTS17 NOTCH2

7.81e-051821075d3a037268f026eb2f84428b1821022503cef7756
ToppCellCerebellum-Endothelial-MURAL|Cerebellum / BrainAtlas - Mouse McCarroll V32

PDE3A VTN REM1 MYLK RRAD

7.81e-051821075b2f03f61aebb5920595fed8b9d6799a09353419b
ToppCellfacs-Lung-nan-3m-Endothelial-Artery_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PDE3A RABGAP1 FBLN2 MMRN2 NOS3

8.01e-05183107512e876d6205af8aad74265c668b5e95b9e7487f3
ToppCellBasal|World / shred by cell class for mouse tongue

MATN2 SHMT1 ASAP2 MEGF6 ZFHX3

8.01e-051831075c6729a207526ff4aa48176207b9353176f631fea
ToppCellfacs-Heart-RA-18m-Mesenchymal-valve_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

VTN REM1 MYLK PACSIN3 NRXN1

8.01e-0518310750f02136359787bd78146617990968baa47a65d86
ToppCellfacs-Heart-RA-18m-Mesenchymal-valve_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

VTN REM1 MYLK PACSIN3 NRXN1

8.01e-0518310752f0dcc65ad4d90ef946919b4462280fdd20c5ea0
ToppCellPND14-Endothelial-Endothelial_blood-vessel-Macrovascular_EC|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

FBLN2 CCM2L MEGF6 MMRN2 NOS3

8.01e-051831075fc9a7ba148c22d0c8a46f6bc56c772929ac496f7
ToppCellnucseq-Immune-Lymphocytic_B|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

NUGGC MYCBP2 BACH2 PLCG2 RUBCN

8.22e-051841075911658e7bb499c1bbc8419eec8ff88729bc39a75
ToppCellfacs-Brain_Non-Myeloid-Striatum-3m-Mesenchymal-brain_pericyte|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PDE3A VTN MYLK RRAD ZFHX3

8.22e-05184107589ae8bf1a6c2d355d279d23a5e24a08d9ec2334e
ToppCellPCW_10-12-Endothelial-Endothelial_mature-endo_arterial_(9)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

EYS CCM2L MMRN2 PLCG2 NOS1

8.22e-051841075a809b0fa52df8a159f60f87eefcef61220af5e34
ToppCellnucseq-Immune-Lymphocytic_B-Lymphocytic_B|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

NUGGC MYCBP2 BACH2 PLCG2 RUBCN

8.22e-051841075942b58ae7172bb5f97e55b032db9329d161854af
ToppCellEndothelial-E|World / shred on cell class and cell subclass (v4)

FBLN2 CCM2L MEGF6 MMRN2 NOS3

8.22e-051841075b4c561924c508536fd2112e91e32176b95fdf63a
ToppCellfacs-Brain_Non-Myeloid-Striatum-3m-Mesenchymal-Pericyte|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PDE3A VTN MYLK RRAD ZFHX3

8.22e-05184107534c84ac9a32eaf96f45b79485119cad65905817d
ToppCellfacs-Brain_Non-Myeloid-Striatum_-18m-Mesenchymal-Pericyte|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PDE3A VTN MYLK RRAD ZFHX3

8.43e-0518510755f5df92b328be396941b5812d00454b5ff927d30
ToppCellCOVID-19-Heart-Fib_2|COVID-19 / Disease (COVID-19 only), tissue and cell type

APCDD1 LAMC1 FBLN2 PXDN LRP1

8.43e-0518510758f95d8e591bf7379d13f5a0545b0cb49e2b1ab5d
ToppCellfacs-Brain_Non-Myeloid-Striatum_-18m-Mesenchymal-brain_pericyte|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PDE3A VTN MYLK RRAD ZFHX3

8.43e-05185107598547c1b1828b76da810ed86082182afaaacdb3f
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L1-3_VIP_ZNF322P1|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

PDE3A PLSCR5 RRAD PXDN ADAMTS17

8.43e-0518510750b5a0df58ae2ad8261f40f152775747af4f3937a
Drugcapsazepine

FOXM1 CACNA1E PLCG2 NOS1 NOS3 ALOX5

2.82e-06841076CID002733484
DrugU46619

CACNA1E PDE3A MYLK CACNA1H PLCG2 NOS1 NOS3 ALOX5 GP5

8.17e-062851079CID000005618
Drugseptacidin

NPC1 PLXNA3 FTCD

8.30e-0691073CID000096278
DrugRussian VX

EPHB2 CACNA1E VTN CLTC GP5

1.09e-05621075CID000178033
DrugL-N(Omega)-Nitroarginine-2,4-L-Diaminobutyric Amide

NOS1 NOS3

2.19e-0521072DB01821
DrugS-Ethyl-N-Phenyl-Isothiourea

NOS1 NOS3

2.19e-0521072DB03707
DrugN-{(3S,4S)-4-[(6-AMINO-4-METHYLPYRIDIN-2-YL)METHYL]PYRROLIDIN-3-YL}-N'-(4-CHLOROBENZYL)ETHANE-1,2-DIAMINE

NOS1 NOS3

2.19e-0521072DB08018
DrugN-{(3R,4S)-4-[(6-amino-4-methylpyridin-2-yl)methyl]pyrrolidin-3-yl}-N'-(3-chlorobenzyl)ethane-1,2-diamine

NOS1 NOS3

2.19e-0521072DB08019
DrugAC1NUV1R

VTN GP5

2.19e-0521072CID005494399
Drugtetrakis(4-benzoic acid)porphyrin

NOS3 ALOX5

2.19e-0521072ctd:C480958
DrugL-N(Omega)-Nitroarginine-(4r)-Amino-L-Proline Amide

NOS1 NOS3

2.19e-0521072DB02077
DrugN-{(4s)-4-Amino-5-[(2-Aminoethyl)Amino]Pentyl}-N'-Nitroguanidine

NOS1 NOS3

2.19e-0521072DB02027
DrugNitroarginine

NOS1 NOS3

2.19e-0521072DB04223
DrugSanguinarine [2447-54-3]; Down 200; 12uM; MCF7; HT_HG-U133A

CYLD VLDLR NEK9 RBM5 RNF41 NOTCH2 SORL1

3.37e-0519110774168_DN
DrugDilazep dihydrochloride [20153-98-4]; Up 200; 6uM; PC3; HT_HG-U133A

EPHB2 CYLD PLXNA3 RIN3 SHMT1 RNF41 PLCG2

3.48e-0519210777364_UP
DrugMedrysone [2668-66-8]; Down 200; 11.6uM; MCF7; HT_HG-U133A

BBS9 NEK9 SETD2 MBNL2 RBM5 CACNA1H SORL1

3.72e-0519410774727_DN
DrugSulfameter [651-06-9]; Down 200; 14.2uM; PC3; HT_HG-U133A

EPHB6 RIN3 MYLK RNF31 ANKRD27 ZFHX3 DBR1

3.72e-0519410775732_DN
DrugPilocarpine nitrate [148-72-1]; Up 200; 14.8uM; MCF7; HT_HG-U133A

EPHB2 VLDLR REM1 SKI BBS9 MMRN2 RNF41

3.84e-0519510773300_UP
DrugBaclofen (R,S) [1134-47-0]; Up 200; 18.8uM; MCF7; HT_HG-U133A

EPHB2 CYLD TRAPPC11 NEK9 MBNL2 RBM5 CACNA1H

3.97e-0519610771536_UP
DrugBromocryptine mesylate [22260-51-1]; Up 200; 5.4uM; MCF7; HT_HG-U133A

CYLD TRAPPC11 REM1 BBS9 NEK9 MBNL2 CACNA1H

4.23e-0519810771507_UP
Drugglutamate

EPHB2 FOXM1 CACNA1E MYLK SHMT1 FTCD CHRNE DHX8 TRIM32 PKLR SCNN1G CACNA1H PLCG2 NOS1 NOS3

4.36e-0596210715CID000000611
DrugW-13

MYLK TRIM32 NOS1 NOS3

5.42e-05441074CID000004299
Drugsulfopyruvate

CACNA1E VTN ACOT12 GP5

6.46e-05461074CID000440717
Drug3-Bromo-7-Nitroindazole

NOS1 NOS3

6.54e-0531072DB01997
Drugtyrphostin 47

CACNA1H NOS3

6.54e-0531072ctd:C060152
DrugN-(3-(Aminomethyl)Benzyl)Acetamidine

NOS1 NOS3

6.54e-0531072DB02044
Drugharderoporphyrinogen

CPOX CLTC

6.54e-0531072CID000193825
DrugHeme

NOS1 NOS3 ALOX5

7.82e-05181073DB03014
Diseasesevere acute respiratory syndrome, COVID-19

EPHB2 RIN3 USP9X BBS9 EYS PXDN MEGF6 NRXN1 MBNL2 ADAMTS17 ZFHX3

5.37e-0744710411EFO_0000694, MONDO_0100096
Diseaseserum IgG glycosylation measurement

CACNA1E BACH2 ZNF407 SKI DHX8 EYS ASAP2 PXDN ADAMTS17 PLCG2

1.65e-0552310410EFO_0005193
DiseaseIntestinal Perforation

NOS1 NOS3

3.68e-0531042C0021845
Diseasemyotonic disease (implicated_via_orthology)

MBNL1 MBNL2

3.68e-0531042DOID:450 (implicated_via_orthology)
Diseaseportal hypertension (implicated_via_orthology)

NOS1 NOS3 ALOX5

3.96e-05191043DOID:10762 (implicated_via_orthology)
Diseasepeak expiratory flow

UTP6 PDE3A APCDD1 EYS ASAP2 ADAMTS17 LRP1 PPP6R3 SORL1

6.88e-054981049EFO_0009718
Diseasecoronary artery disease

NPC1 MORN1 LAMC1 SKI NEK9 ASAP2 FBN2 NRXN1 LRP1 ZNF727 PLCG2 GPSM1 NOS3 NUP160

7.79e-05119410414EFO_0001645
DiseaseObesity

NPC1 VLDLR APCDD1 PHF6 BBS9 ZFHX3

9.01e-052051046C0028754
Diseasesystemic mastocytosis

CACNA1E EYS MEGF6

9.25e-05251043MONDO_0016586
DiseaseAlzheimer's disease (is_implicated_in)

VLDLR LRP1 NOS1 NOS3 SORL1

1.07e-041321045DOID:10652 (is_implicated_in)
DiseaseInsulinogenic index measurement

MYCBP2 GPSM1

1.22e-0451042EFO_0009961
Diseaseirritable bowel syndrome (implicated_via_orthology)

EPHB2 NOS3

1.22e-0451042DOID:9778 (implicated_via_orthology)
Diseasemyotonic dystrophy type 2 (implicated_via_orthology)

MBNL1 MBNL2

1.22e-0451042DOID:0050759 (implicated_via_orthology)
Diseasemyotonic dystrophy type 1 (implicated_via_orthology)

MBNL1 MBNL2

1.83e-0461042DOID:11722 (implicated_via_orthology)
Diseaseretinal degeneration (implicated_via_orthology)

EYS NOS3 VDAC2

2.15e-04331043DOID:8466 (implicated_via_orthology)
Diseaseasthma (is_implicated_in)

MYLK CHML NOS1 NOS3 ALOX5

2.41e-041571045DOID:2841 (is_implicated_in)
Diseasebrain ischemia (implicated_via_orthology)

NOS1 NOS3 ALOX5

2.56e-04351043DOID:2316 (implicated_via_orthology)
Diseasepoly(A) RNA polymerase, mitochondrial measurement

VTN MTPAP

3.40e-0481042EFO_0801893
DiseaseN-acetylneuraminate measurement

LAMC1 ASAP2

3.40e-0481042EFO_0020022
Diseasepulse pressure measurement

NPC1 RIN3 PDE3A MBNL1 RABGAP1 ANKRD36C INTS8 NEK9 DHX8 ASAP2 FBN2 LRP1 ZFHX3 NUP160

3.79e-04139210414EFO_0005763
Diseasemyeloid white cell count

NPC1 VLDLR RIN3 PDE3A BACH2 MBNL1 SETD2 ZFHX3 NUP160 NOTCH2 SORL1

4.74e-0493710411EFO_0007988
DiseaseDiabetes, Autoimmune

BACH2 NOS1 NOS3

5.07e-04441043C0205734
DiseaseBrittle diabetes

BACH2 NOS1 NOS3

5.07e-04441043C0342302
DiseaseDiabetes Mellitus, Sudden-Onset

BACH2 NOS1 NOS3

5.07e-04441043C4554117
DiseaseDiabetes Mellitus, Ketosis-Prone

BACH2 NOS1 NOS3

5.07e-04441043C3837958
DiseaseDiabetes Mellitus, Insulin-Dependent

BACH2 NOS1 NOS3

5.42e-04451043C0011854
Diseasediabetic retinopathy (biomarker_via_orthology)

VTN NOS1 NOS3

5.42e-04451043DOID:8947 (biomarker_via_orthology)
DiseaseHMG CoA reductase inhibitor use measurement

MORN1 DHRS11 SKI SETD2 NOS3

5.63e-041891045EFO_0009932
DiseaseFamilial thoracic aortic aneurysm and aortic dissection

MYLK SKI FBN2

8.77e-04531043C4707243
Diseasecardiomyopathy (biomarker_via_orthology)

NOS1 NOS3

9.36e-04131042DOID:0050700 (biomarker_via_orthology)
DiseaseBardet-Biedl syndrome (is_implicated_in)

BBS9 TRIM32

1.09e-03141042DOID:1935 (is_implicated_in)
DiseaseAutosomal recessive limb-girdle muscular dystrophy

TRAPPC11 TRIM32

1.09e-03141042cv:C2931907
DiseaseAtherosclerosis

NPC1 NOS3 ALOX5

1.20e-03591043C0004153
DiseaseAtherogenesis

NPC1 NOS3 ALOX5

1.20e-03591043C1563937
Diseasemyocardial infarction

MORN1 LAMC1 SKI PLCG2 GPSM1 NOS3

1.53e-033501046EFO_0000612
DiseaseBardet-Biedl syndrome 1 (disorder)

BBS9 TRIM32

1.62e-03171042C2936862
DiseaseBardet-Biedl syndrome

BBS9 TRIM32

1.81e-03181042cv:C0752166
DiseaseAlzheimer disease, educational attainment

NPC1 LAMC1 NRXN1 RBM5 SORL1

1.85e-032471045EFO_0011015, MONDO_0004975
Diseasecolorectal cancer, colorectal adenoma

LAMC1 LRP1 TTC22 NOS1

2.09e-031521044EFO_0005406, MONDO_0005575
DiseaseParoxysmal atrial fibrillation

LHX3 ZFHX3 NOS3 SORL1

2.29e-031561044C0235480
Diseasefamilial atrial fibrillation

LHX3 ZFHX3 NOS3 SORL1

2.29e-031561044C3468561
DiseasePersistent atrial fibrillation

LHX3 ZFHX3 NOS3 SORL1

2.29e-031561044C2585653
Diseasebone density, lean body mass

RIN3 PPP6R3

2.47e-03211042EFO_0003923, EFO_0004995
Diseasehemoglobin A1 measurement

PDE3A MBNL1 SKI ANKRD27 SETD2 GPSM1 NOTCH2

2.48e-035201047EFO_0007629
DiseaseAtrial Fibrillation

LHX3 ZFHX3 NOS3 SORL1

2.51e-031601044C0004238
Diseaseepilepsy (implicated_via_orthology)

CACNA1E LRP1 NOS1 NOS3

2.69e-031631044DOID:1826 (implicated_via_orthology)
Diseaseimpotence (biomarker_via_orthology)

NOS1 NOS3

2.71e-03221042DOID:1875 (biomarker_via_orthology)
Diseasepulmonary hypertension (biomarker_via_orthology)

PDE3A NOS3 ALOX5

2.87e-03801043DOID:6432 (biomarker_via_orthology)
DiseaseQT interval

PDE3A LAMC1 PXDN ZFHX3 NUP160 CDC23 PPP6R3

2.87e-035341047EFO_0004682
Diseasechronic widespread pain

ASAP2 PLCG2

2.97e-03231042EFO_0010099
Diseasetemperament and character inventory

FBN2 NRXN1

3.23e-03241042EFO_0004825
Diseasenephrotic syndrome (biomarker_via_orthology)

VLDLR NOS1

3.23e-03241042DOID:1184 (biomarker_via_orthology)
DiseaseAllodynia

CACNA1H NOS1 ALOX5

3.30e-03841043C0458247
DiseaseMechanical Allodynia

CACNA1H NOS1 ALOX5

3.30e-03841043C2936719
DiseaseHyperalgesia, Secondary

CACNA1H NOS1 ALOX5

3.30e-03841043C0751212
DiseaseHyperalgesia, Primary

CACNA1H NOS1 ALOX5

3.30e-03841043C0751211
DiseaseHyperalgesia, Thermal

CACNA1H NOS1 ALOX5

3.30e-03841043C0751214
DiseaseTactile Allodynia

CACNA1H NOS1 ALOX5

3.30e-03841043C0751213
DiseaseHyperalgesia

CACNA1H NOS1 ALOX5

3.30e-03841043C0020429
DiseaseLeukemia, Myelocytic, Acute

BACH2 SETD2 PXDN NOTCH2

3.33e-031731044C0023467
DiseaseColorectal Carcinoma

EPHB6 LAMC1 FBLN2 FBN2 LRP1 SCNN1G MMRN2 SORL1

3.43e-037021048C0009402

Protein segments in the cluster

PeptideGeneStartEntry
SEDGLFVCRKDAACQ

BACH2

136

Q9BYV9
CCAFNDTREEGKALL

CDC23

536

Q9UJX2
CGVEADKELSCRQQA

CCNT2

26

O60583
CEREACANILIDAGA

ANKRD30B

116

Q9BXX2
ECSLEKNERACIDFA

CACNA1E

1436

Q15878
QTCVEVGVRVEAFDC

ACOT12

256

Q8WYK0
RVLTADFCAGCKVND

ADCK5

311

Q3MIX3
DFCAGCKVNDVEAIR

ADCK5

316

Q3MIX3
CTELRDKIACNGDAS

ATAD2

1261

Q6PL18
RDAAEESCALICQVF

CCM2L

311

Q9NUG4
VCSAKRKCVLAEDNG

ADAMTS17

366

Q8TE56
AAPEVRCCVDAVNFV

CHRNE

416

Q04844
VQCFVVDKESGRCKA

CHML

406

P26374
RDQCLAVCDGVLGVF

ERAS

106

Q7Z444
TIDEKRLAGYCQACD

INTS8

296

Q75QN2
DEGRACAVVFDCKFI

RRAD

216

P55042
RDQELAFQGTVDKCC

ANKRD36C

1486

Q5JPF3
FCDDCEKLVSGRLND

ANKRD27

436

Q96NW4
ACQRVEQGCAEFTDV

MORN1

356

Q5T089
VDDCERCREFFNKEG

RABGAP1

966

Q9Y3P9
ADKARDGVCDEACNS

NOTCH2

1431

Q04721
KDCAVIEGQDFVLQC

MYLK

521

Q15746
LAEDGKRCVAVDYCA

MATN2

311

O00339
DANQHCICREEFEGK

EYS

871

Q5T1H1
KAIRQVSCGDDFTVC

NEK9

426

Q8TD19
LKVLGRFDEAAVCCQ

GPSM1

116

Q86YR5
NDVKNVGRCCEAEAG

MMRN2

706

Q9H8L6
ICGDEARCVRTEKAA

LRP1

3791

Q07954
TQALEKFGGNCVCRD

ASAP2

76

O43150
LNADEAVARGCALQC

HSPH1

366

Q92598
CKAGFEAVENGTVCR

EPHB2

256

P29323
ADGKRCEDVNECEAQ

FBLN2

936

P98095
CGCFGDVDFEVKTIN

PLSCR5

196

A0PG75
VELCVGDCSADFRTQ

PLXNA3

911

P51805
VRGEVGCDLEQCKEA

PDE3A

81

Q14432
ECFNKISRDADCRAV

ECH1

91

Q13011
AIGAVEAAFKCCAAA

PKLR

456

P30613
FACVVCKRQLATGDE

LHX3

116

Q9UBR4
CDILEAANKRGVFVC

FAM83A

176

Q86UY5
DFERAKAVRQKEDCC

PLCG2

81

P16885
VVDDQAVCDCSRTGF

NRXN1

236

Q9ULB1
ADAEDKCVIEGNNCT

MTPAP

406

Q9NVV4
CFRCGADKFDSEQEV

RBM5

201

P52756
DKEEFDQGCLCLANV

BBS9

16

Q3SYG4
KAACDVFCVGDDVNI

NOS1

941

P29475
ACETFCVGEDAKAAA

NOS3

706

P29474
EVEDAVQKVCNATGC

OTUD3

231

Q5T2D3
EKNRLDIFCCVRGAE

NPC1

791

O15118
CRKEIQGFLDCAARA

CHCHD1

66

Q96BP2
EDELCFLRANECKTG

DPP9

436

Q86TI2
GRTVALCENDCDDKA

DIS3L

306

Q8TF46
EGCIAAENCIGIRDF

GAN

126

Q9H2C0
REENGCECTKAVNFA

APCDD1

191

Q8J025
KSCQVENGRVIACFD

MBNL1

41

Q9NR56
KSCQVENGRVIACFD

MBNL2

41

Q5VZF2
TDKLEVCREFQRGNC

MBNL2

176

Q5VZF2
EQKRETCADGEAAGC

FOXM1

161

Q08050
KCVFRDAAQCSGGDV

GP5

26

P40197
GRCVCKDNVEGFNCE

LAMC1

461

P11047
CCGDFQAVRNEADLR

DBR1

36

Q9UK59
ARIKGVTCEDVNECE

FBN2

946

P35556
LFQCDEDCGVFVALD

CYLD

186

Q9NQC7
VECGSERCNILEAFD

CACNA1H

126

O95180
CARTVGNIEELAAEC

DHRS11

41

Q6UWP2
AVCIADREEKGCTSQ

DHX40

31

Q8IX18
AKGFICEFCQNEDDI

RUBCN

886

Q92622
IACDNAVFGCSAVVR

RNF41

81

Q9H4P4
AFVQEELGCQSVCKE

SCNN1G

441

P51170
SCVLQDGCVFEKAGV

CPOX

191

P36551
LAGQIARACAIFCVD

SPOUT1

96

Q5T280
VAKRVSEEFGCCLGQ

DHX8

626

Q14562
VDECVLCAQAFGQRL

FTCD

101

O95954
CICDLARSIDFNKDG

PPEF2

696

O14830
CGDLVSCFQERARIE

PACSIN3

36

Q9UKS6
SVEEGRACAVVFDCK

REM1

206

O75628
CAQCAEKFAVERPQA

RIN3

906

Q8TB24
GRAEKVLEACSIACN

SHMT1

371

P34896
KACEDVDECAAGLAQ

MEGF6

281

O75095
CVLDGDKDSVNCARQ

USP9X

831

Q93008
QAKAVEVGRKEERCC

UTP6

296

Q9NYH9
SREFQCEDGEACIVL

SORL1

1516

Q92673
ESIKACQRGFCRDVA

NUGGC

336

Q68CJ6
ENEDFRCIAGMCVDA

TRIM32

571

Q13049
AREQLICECGLFDKA

ALOX5

411

P09917
LLFNVVCKECEGRQE

EPHB6

401

O15197
KDQVFGCALAALCER

ARHGAP27

691

Q6ZUM4
VGVESACDVDCRFKL

SIN3B

1046

O75182
CKACARELDGQEARQ

MYCBP2

811

O75592
CANCGKELTADAREL

LIMS1

161

P48059
ALECFCQAASEVGKE

NUP160

926

Q12769
LEQARQARVCDKGCE

SKI

641

P12755
VCFACVDGKEFRLAQ

CLTC

1256

Q00610
GIKRDFATVCQECTD

C12orf4

341

Q9NQ89
FENEAAAVLCSICER

RNF31

361

Q96EP0
EECGKDCRLSDFTIQ

ZNF727

176

A8MUV8
KCGFCHVGEEENEAR

PHF6

211

Q8IWS0
ERAAALCNACELSGK

TRAPPC11

156

Q7Z392
LNADEAVARGCALQC

HSPA4L

366

O95757
ICECKDGQVTCFVEA

PXDN

1436

Q92626
ELDFACDQCGRRFEK

ZNF276

551

Q8N554
RECINLGCDVDFDFA

VDAC2

131

P45880
KDERAQGEIACGEDC

SETD2

1506

Q9BYW2
GNIERECKEEFCTFE

PRRG1

31

O14668
FEECIERVCIGANDK

ZNF407

771

Q9C0G0
GNIALFEACCKERIQ

PPP6R3

596

Q5H9R7
FEACCKERIQQFDDG

PPP6R3

601

Q5H9R7
CLRIKGEDANAAACF

TTC22

441

Q5TAA0
GEDANAAACFKRAVE

TTC22

446

Q5TAA0
VALADQESCKGRCTE

VTN

16

P04004
VCRKCQAGFSDEEAA

ZFHX3

3466

Q15911
EQKGDCAAALALCNE

USP54

811

Q70EL1
RDCVDGSDEVNCKNV

VLDLR

301

P98155