Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionC-acyltransferase activity

ACAT2 ACSM5 HADHB

2.12e-04211123GO:0016408
GeneOntologyMolecularFunctionhydro-lyase activity

CYP1A2 DGLUCY HADHB HSD17B4

4.33e-04631124GO:0016836
GeneOntologyMolecularFunction3-hydroxyacyl-CoA dehydrogenase activity

HADHB HSD17B4

4.61e-0461122GO:0003857
GeneOntologyMolecularFunctionacetyl-CoA C-acetyltransferase activity

ACAT2 HADHB

4.61e-0461122GO:0003985
GeneOntologyMolecularFunctionC-acetyltransferase activity

ACAT2 HADHB

6.43e-0471122GO:0016453
GeneOntologyMolecularFunctionacetyl-CoA C-acyltransferase activity

ACAT2 HADHB

6.43e-0471122GO:0003988
GeneOntologyCellularComponentcostamere

ANK3 CMYA5 AHNAK VCL

5.49e-06221134GO:0043034
GeneOntologyCellularComponentaxonemal central pair projection

CFAP69 HYDIN

2.90e-0521132GO:1990718
GeneOntologyCellularComponentsecretory granule lumen

APAF1 F13A1 ITIH4 MAPK1 HSPA6 VCL PROS1 VAT1

3.90e-043251138GO:0034774
GeneOntologyCellularComponentaxonemal central apparatus

CFAP69 HYDIN

4.28e-0461132GO:1990716
GeneOntologyCellularComponentcytoplasmic vesicle lumen

APAF1 F13A1 ITIH4 MAPK1 HSPA6 VCL PROS1 VAT1

4.31e-043301138GO:0060205
GeneOntologyCellularComponentvesicle lumen

APAF1 F13A1 ITIH4 MAPK1 HSPA6 VCL PROS1 VAT1

4.49e-043321138GO:0031983
GeneOntologyCellularComponentanchoring junction

ANK3 GRHL2 JAK1 CORO2B ARHGEF7 FMN1 AHNAK PIP5K1A DLG3 GJB7 MAPK1 SCIN PCDH9 VCL

7.91e-0497611314GO:0070161
GeneOntologyCellularComponentblood microparticle

F13A1 ITIH4 HSPA6 HSPA7 PROS1

1.12e-031441135GO:0072562
DomainJIP_LZII

SPAG9 MAPK8IP3

3.44e-0521102IPR032486
DomainJIP_LZII

SPAG9 MAPK8IP3

3.44e-0521102PF16471
DomainJNK/Rab-associated_protein-1_N

SPAG9 MAPK8IP3

2.05e-0441102IPR019143
DomainJnk-SapK_ap_N

SPAG9 MAPK8IP3

2.05e-0441102PF09744
DomainThiolase_AS

ACAT2 HADHB

3.40e-0451102IPR020610
DomainRH2

SPAG9 MAPK8IP3

3.40e-0451102PS51777
DomainRH1

SPAG9 MAPK8IP3

3.40e-0451102PS51776
DomainThiolase_C

ACAT2 HADHB

5.08e-0461102PF02803
DomainTHIOLASE_2

ACAT2 HADHB

5.08e-0461102PS00737
DomainTHIOLASE_1

ACAT2 HADHB

5.08e-0461102PS00098
DomainTHIOLASE_3

ACAT2 HADHB

5.08e-0461102PS00099
DomainThiolase_N

ACAT2 HADHB

5.08e-0461102IPR020616
DomainThiolase_C

ACAT2 HADHB

5.08e-0461102IPR020617
DomainThiolase_CS

ACAT2 HADHB

5.08e-0461102IPR020613
DomainThiolase

ACAT2 HADHB

5.08e-0461102IPR002155
DomainThiolase_N

ACAT2 HADHB

5.08e-0461102PF00108
Domain-

ACAT2 HADHB

1.50e-031011023.40.47.10
DomainThiolase-like

ACAT2 HADHB

1.50e-03101102IPR016039
Domain-

APAF1 SPAG9 SEC31A WDFY4 MAPK8IP3 CORO2B EIF3B

3.57e-0333311072.130.10.10
DomainWD40/YVTN_repeat-like_dom

APAF1 SPAG9 SEC31A WDFY4 MAPK8IP3 CORO2B EIF3B

3.69e-033351107IPR015943
DomainHSP70

HSPA6 HSPA7

3.91e-03161102PF00012
DomainHSP70_2

HSPA6 HSPA7

4.41e-03171102PS00329
DomainHSP70_1

HSPA6 HSPA7

4.41e-03171102PS00297
DomainHSP70_3

HSPA6 HSPA7

4.41e-03171102PS01036
DomainHsp_70_fam

HSPA6 HSPA7

4.95e-03181102IPR013126
Pubmed

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Membrane (M) and Spike (S) Proteins Antagonize Host Type I Interferon Response.

STAT1 JAK1 TBK1 MAPK1

7.65e-0813114434950606
Pubmed

Identification of proximal SUMO-dependent interactors using SUMO-ID.

ZBTB33 ZMYM2 BAZ1B SPAG9 STAT1 ZZZ3 AHNAK MITF AHCY HSPA6 SENP5

2.57e-074441141134795231
Pubmed

SERBP1 Promotes Stress Granule Clearance by Regulating 26S Proteasome Activity and G3BP1 Ubiquitination and Protects Male Germ Cells from Thermostimuli Damage.

PRMT8 ACAT2 LARS1 SPAG9 SEC31A FANCI AHCY HADHB MAPK1 HSD17B4 HSPA6 HSPA7 CDK3 VAT1

1.17e-068781141437223481
Pubmed

Identifying biological pathways that underlie primordial short stature using network analysis.

POLR2A LARS1 BAZ1B STAT1 EHD4 AHNAK TBK1 AHCY UHRF1 TAF15 EIF3B HADHB MAPK1 HSD17B4 SCIN

1.35e-0610241141524711643
Pubmed

Growth hormone synergizes with BMP9 in osteogenic differentiation by activating the JAK/STAT/IGF1 pathway in murine multilineage cells.

GDF2 STAT1 JAK1

2.84e-069114322467218
Pubmed

Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.

POLR2A LARS1 BAZ1B SEC31A CMYA5 STAT1 EHD4 SLC38A1 FANCI TBK1 AHCY UHRF1 EIF3B HADHB HSD17B4 VCL VAT1

4.07e-0614251141730948266
Pubmed

The p300/YY1/miR-500a-5p/HDAC2 signalling axis regulates cell proliferation in human colorectal cancer.

LARS1 PPM1H ARHGEF7 AHNAK TBK1 TAF15 EIF3B VCL

6.63e-06298114830737378
Pubmed

Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.

ANK3 POLR2A SPAG9 PPM1H EHD4 SLC38A1 FANCI AHNAK HADHB MAPK1 HSD17B4 SCIN HSPA6 VAT1

9.00e-0610491141427880917
Pubmed

Cytokine receptor signalling through two novel families of transducer molecules: Janus kinases, and signal transducers and activators of transcription.

STAT1 JAK1

1.07e-05211427490523
Pubmed

p38 mitogen-activated protein kinase interacts with vinculin at focal adhesions during fatty acid-stimulated cell adhesion.

MAPK1 VCL

1.07e-052114224219282
Pubmed

Targeted disruption of the Stat1 gene in mice reveals unexpected physiologic specificity in the JAK-STAT signaling pathway.

STAT1 JAK1

1.07e-05211428608597
Pubmed

Overlapping roles of JIP3 and JIP4 in promoting axonal transport of lysosomes in human iPSC-derived neurons.

SPAG9 MAPK8IP3

1.07e-052114233788575
Pubmed

Measles virus V protein blocks Jak1-mediated phosphorylation of STAT1 to escape IFN-alpha/beta signaling.

STAT1 JAK1

1.07e-052114217686504
Pubmed

Regulation of STAT1 nuclear export by Jak1.

STAT1 JAK1

1.07e-052114210982844
Pubmed

Structural characterization of the RH1-LZI tandem of JIP3/4 highlights RH1 domains as a cytoskeletal motor-binding motif.

SPAG9 MAPK8IP3

1.07e-052114231690808
Pubmed

The human heat-shock genes HSPA6 and HSPA7 are both expressed and localize to chromosome 1.

HSPA6 HSPA7

1.07e-05211421346391
Pubmed

Sandfly Fever Viruses Attenuate the Type I Interferon Response by Targeting the Phosphorylation of JAK-STAT Components.

STAT1 JAK1

1.07e-052114235720342
Pubmed

Mitochondrial dynamics regulate melanogenesis through proteasomal degradation of MITF via ROS-ERK activation.

MITF MAPK1

1.07e-052114225065405
Pubmed

Aged intestinal stem cells propagate cell-intrinsic sources of inflammaging in mice.

LGR5 STAT1

1.07e-052114238113852
Pubmed

SARS-CoV-2 NSP13 helicase suppresses interferon signaling by perturbing JAK1 phosphorylation of STAT1.

STAT1 JAK1

1.07e-052114235317858
Pubmed

Aspirin enhances IFN-α-induced growth inhibition and apoptosis of hepatocellular carcinoma via JAK1/STAT1 pathway.

STAT1 JAK1

1.07e-052114223703473
Pubmed

JAK/STAT pathway and molecular mechanism in bone remodeling.

STAT1 JAK1

1.07e-052114233099760
Pubmed

Multiple ras downstream pathways mediate functional repression of the homeobox gene product TTF-1.

NKX2-1 MAPK1

1.07e-052114210733581
Pubmed

Association study of FLT4 and HYDIN single nucleotide polymorphisms with atrial septal defect susceptibility in the Han Chinese population of Southwest China.

FLT4 HYDIN

1.07e-052114238581027
Pubmed

Lysines in the RNA Polymerase II C-Terminal Domain Contribute to TAF15 Fibril Recruitment.

POLR2A TAF15

1.07e-052114228945358
Pubmed

hTAF(II)68, a novel RNA/ssDNA-binding protein with homology to the pro-oncoproteins TLS/FUS and EWS is associated with both TFIID and RNA polymerase II.

POLR2A TAF15

1.07e-05211428890175
Pubmed

SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.

ZBTB33 ANK3 POLR2A BAZ1B SPAG9 STAT1 ZZZ3 AHNAK HSPA6 VCL

1.39e-055491141038280479
Pubmed

C9orf72 protein quality control by UBR5-mediated heterotypic ubiquitin chains.

ZBTB33 HDHD5 POLR2A LARS1 STAT1 FANCI AHCY TAF15 EIF3B HADHB MAPK1 HSD17B4 DNA2 HSPA6 VAT1

1.58e-0512571141537317656
Pubmed

Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.

TANC2 ANK3 ZMYM2 CNKSR2 SEC31A PPM1H ITIH4 MAPK8IP3 ARHGEF7 TBK1 DLG3 TAF15 MAPK1

1.71e-059631141328671696
Pubmed

Deficit of mitogen-activated protein kinase phosphatase 1 (DUSP1) accelerates progressive hearing loss.

POLR2A APAF1 UCP1 MAPK1

1.91e-0548114430938680
Pubmed

Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage.

ANK3 CMYA5 EHD4 AHNAK TBK1 AHCY TAF15 EIF3B HADHB MAPK1 HSPA6 HSPA7

2.22e-058441141225963833
Pubmed

Ggnbp2 Is Essential for Pregnancy Success via Regulation of Mouse Trophoblast Stem Cell Proliferation and Differentiation.

FLT4 STAT1 JAK1 MAPK1

2.43e-0551114426764350
Pubmed

Large-scale proteomics and phosphoproteomics of urinary exosomes.

APAF1 CNKSR2 SPAG9 GDF2 ITIH4 EHD4 MVB12A AHNAK ASL AHCY SCIN VCL VAT1

2.98e-0510161141319056867
Pubmed

Downregulated SOCS1 expression activates the JAK1/STAT1 pathway and promotes polarization of macrophages into M1 type.

STAT1 JAK1

3.19e-053114228901399
Pubmed

Progesterone activates Janus Kinase 1/2 and activators of transcription 1 (JAK1-2/STAT1) pathway in human spermatozoa.

STAT1 JAK1

3.19e-053114222748021
Pubmed

Hepatitis C virus-mediated enhancement of microRNA miR-373 impairs the JAK/STAT signaling pathway.

STAT1 JAK1

3.19e-053114225589644
Pubmed

Foot-and-mouth disease virus structural protein VP3 degrades Janus kinase 1 to inhibit IFN-γ signal transduction pathways.

STAT1 JAK1

3.19e-053114226901336
Pubmed

MicroRNA-9 Inhibits NLRP3 Inflammasome Activation in Human Atherosclerosis Inflammation Cell Models through the JAK1/STAT Signaling Pathway.

STAT1 JAK1

3.19e-053114228334721
Pubmed

Interleukin-29 binds to melanoma cells inducing Jak-STAT signal transduction and apoptosis.

STAT1 JAK1

3.19e-053114220103601
Pubmed

The scaffold protein JIP3 functions as a downstream effector of the small GTPase ARF6 to regulate neurite morphogenesis of cortical neurons.

SPAG9 MAPK8IP3

3.19e-053114220493856
Pubmed

Type III Interferon Induces Distinct SOCS1 Expression Pattern that Contributes to Delayed but Prolonged Activation of Jak/STAT Signaling Pathway: Implications for Treatment Non-Response in HCV Patients.

STAT1 JAK1

3.19e-053114226193702
Pubmed

The Chemopreventive Phytochemical Moringin Isolated from Moringa oleifera Seeds Inhibits JAK/STAT Signaling.

STAT1 JAK1

3.19e-053114227304884
Pubmed

JSAP1/JIP3 and JLP regulate kinesin-1-dependent axonal transport to prevent neuronal degeneration.

SPAG9 MAPK8IP3

3.19e-053114225571974
Pubmed

RNF220 mediates K63-linked polyubiquitination of STAT1 and promotes host defense.

STAT1 JAK1

3.19e-053114232814877
Pubmed

Modulation of innate and adaptive immune responses by tofacitinib (CP-690,550).

STAT1 JAK1

3.19e-053114221383241
Pubmed

The protein tyrosine kinase JAK1 complements defects in interferon-alpha/beta and -gamma signal transduction.

STAT1 JAK1

3.19e-05311428232552
Pubmed

Baicalin positively regulates osteoclast function by activating MAPK/Mitf signalling.

MITF MAPK1

3.19e-053114228158928
Pubmed

A novel viral SOCS from infectious spleen and kidney necrosis virus: interacts with Jak1 and inhibits IFN-α induced Stat1/3 activation.

STAT1 JAK1

3.19e-053114222844427
Pubmed

Elevated inorganic phosphate stimulates Akt-ERK1/2-Mnk1 signaling in human lung cells.

MKNK1 MAPK1

3.19e-053114216763222
Pubmed

JAK1-STAT1-STAT3, a key pathway promoting proliferation and preventing premature differentiation of myoblasts.

STAT1 JAK1

3.19e-053114217908914
Pubmed

Dynamic production of tumour necrosis factor-alpha (TNF-alpha) messenger RNA, intracellular and extracellular TNF-alpha by murine macrophages and possible association with protein tyrosine phosphorylation of STAT1 alpha and ERK2 as an early signal.

STAT1 MAPK1

3.19e-05311428675207
Pubmed

SARS-CoV-2 Spike protein enhances ACE2 expression via facilitating Interferon effects in bronchial epithelium.

STAT1 JAK1

3.19e-053114234228987
Pubmed

Aloin suppresses lipopolysaccharide‑induced inflammation by inhibiting JAK1‑STAT1/3 activation and ROS production in RAW264.7 cells.

STAT1 JAK1

3.19e-053114230066904
Pubmed

Macrophage neogenin deficiency exacerbates myocardial remodeling and inflammation after acute myocardial infarction through JAK1-STAT1 signaling.

STAT1 JAK1

3.19e-053114237824022
Pubmed

ICBP90 mediates the ERK1/2 signaling to regulate the proliferation of Jurkat T cells.

UHRF1 MAPK1

3.19e-053114219328461
Pubmed

JAK1 signaling in dendritic cells promotes peripheral tolerance in autoimmunity through PD-L1-mediated regulatory T cell induction.

STAT1 JAK1

3.19e-053114235196494
Pubmed

Iron chelators and hypoxia mimetics inhibit IFNgamma-mediated Jak-STAT signaling.

STAT1 JAK1

3.19e-053114218787531
Pubmed

Herpes Simplex Virus 1 UL36USP Antagonizes Type I Interferon-Mediated Antiviral Innate Immunity.

STAT1 JAK1

3.19e-053114229997210
Pubmed

JSAP1 and JLP are required for ARF6 localization to the midbody in cytokinesis.

SPAG9 MAPK8IP3

3.19e-053114225130574
Pubmed

A neurally enriched coronin-like protein, ClipinC, is a novel candidate for an actin cytoskeleton-cortical membrane-linking protein.

CORO2B VCL

3.19e-053114210224093
Pubmed

ERK1/2-mediated phosphorylation of small hepatitis delta antigen at serine 177 enhances hepatitis delta virus antigenomic RNA replication.

POLR2A MAPK1

3.19e-053114218632853
Pubmed

Critical role of JSAP1 and JLP in axonal transport in the cerebellar Purkinje cells of mice.

SPAG9 MAPK8IP3

3.19e-053114226320416
Pubmed

Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.

ACAT2 POLR2A LARS1 BAZ1B SEC31A STAT1 EHD4 FANCI AHNAK AHCY EIF3B HADHB MAPK1 HSPA6 VCL

3.69e-0513531141529467282
Pubmed

Morphogenesis of the telencephalic commissure requires scaffold protein JNK-interacting protein 3 (JIP3).

SPAG9 MAPK8IP3 MAPK1

3.75e-0520114312897243
Pubmed

CHK2-BRCA1 tumor-suppressor axis restrains oncogenic Aurora-A kinase to ensure proper mitotic microtubule assembly.

MAGEB2 LARS1 SPAG9 SEC31A AHNAK AHCY TAF15 EIF3B VCL

3.80e-05494114926831064
Pubmed

Role of the JIP4 scaffold protein in the regulation of mitogen-activated protein kinase signaling pathways.

SPAG9 MAPK8IP3 MAPK1

5.05e-0522114315767678
Pubmed

Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes.

ACAT2 POLR2A SPAG9 ARHGEF7 ACTR6 AHNAK TBK1 UHRF1 PIP5K1A HADHB

5.42e-056451141025281560
Pubmed

Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.

ACAT2 HDHD5 FSIP2 DGLUCY UCP1 ACSM5 UQCC1 HADHB HSD17B4 MMUT COX14 CYB5R1

5.43e-059261141220877624
Pubmed

N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.

ZBTB33 POLR2A LARS1 ZMYM2 BAZ1B SPAG9 STAT1 AHNAK AHCY TAF15 SCIN VCL

5.90e-059341141233916271
Pubmed

PDGF-BB induces PRMT1 expression through ERK1/2 dependent STAT1 activation and regulates remodeling in primary human lung fibroblasts.

STAT1 MAPK1

6.36e-054114226795953
Pubmed

Shp-2 contributes to anti-RSV activity in human pulmonary alveolar epithelial cells by interfering with the IFN-α-induced Jak/Stat1 pathway.

STAT1 JAK1

6.36e-054114226119280
Pubmed

The LIM protein AJUBA promotes colorectal cancer cell survival through suppression of JAK1/STAT1/IFIT2 network.

STAT1 JAK1

6.36e-054114227893714
Pubmed

Dipyrithione inhibits IFN-gamma-induced JAK/STAT1 signaling pathway activation and IP-10/CXCL10 expression in RAW264.7 cells.

STAT1 JAK1

6.36e-054114220372968
Pubmed

The E3 ligase HECTD3 promotes esophageal squamous cell carcinoma (ESCC) growth and cell survival through targeting and inhibiting caspase-9 activation.

APAF1 MAPK1

6.36e-054114228716524
Pubmed

TRIM22 inhibits respiratory syncytial virus replication by targeting JAK-STAT1/2 signaling.

STAT1 JAK1

6.36e-054114232803897
Pubmed

Selective targeting of JAK/STAT signaling is potentiated by Bcl-xL blockade in IL-2-dependent adult T-cell leukemia.

STAT1 JAK1

6.36e-054114226396258
Pubmed

MAP kinase links the transcription factor Microphthalmia to c-Kit signalling in melanocytes.

MITF MAPK1

6.36e-05411429440696
Pubmed

Midkine induces tumor cell proliferation and binds to a high affinity signaling receptor associated with JAK tyrosine kinases.

STAT1 JAK1

6.36e-05411429452495
Pubmed

Transcriptional activation of APAF1 by KAISO (ZBTB33) and p53 is attenuated by RelA/p65.

ZBTB33 APAF1

6.36e-054114226183023
Pubmed

Role of mitogen-activated protein kinase activation in injured and intact primary afferent neurons for mechanical and heat hypersensitivity after spinal nerve ligation.

MAPK8IP3 MAPK1

6.36e-054114215537893
Pubmed

Regulation of the Jak/STAT signalling pathway.

STAT1 JAK1

6.36e-05411428593242
Pubmed

Tumoricidal effects of the JAK inhibitor Ruxolitinib (INC424) on hepatocellular carcinoma in vitro.

STAT1 JAK1

6.36e-054114223941832
Pubmed

Interferon-γ stimulates human follicular dendritic cell-like cells to produce prostaglandins via the JAK-STAT pathway.

STAT1 JAK1

6.36e-054114225818476
Pubmed

Activation of ERK and NF-κB during HARE-Mediated Heparin Uptake Require Only One of the Four Endocytic Motifs.

STAB2 MAPK1

6.36e-054114227100626
Pubmed

Lymphatics act as a signaling hub to regulate intestinal stem cell activity.

FLT4 LGR5

6.36e-054114235728595
Pubmed

Correlation of EGFR Del 19 with Fn14/JAK/STAT signaling molecules in non-small cell lung cancer.

STAT1 JAK1

6.36e-054114227350337
Pubmed

MicroRNA 452 regulates IL20RA-mediated JAK1/STAT3 pathway in inflammatory colitis and colorectal cancer.

STAT1 JAK1

6.36e-054114234283251
Pubmed

SARS-CoV-2 N protein antagonizes type I interferon signaling by suppressing phosphorylation and nuclear translocation of STAT1 and STAT2.

STAT1 JAK1

6.36e-054114232953130
Pubmed

IFNγ-Stat1 axis drives aging-associated loss of intestinal tissue homeostasis and regeneration.

LGR5 STAT1

6.36e-054114237777550
Pubmed

Trim65 attenuates isoproterenol-induced cardiac hypertrophy by promoting autophagy and ameliorating mitochondrial dysfunction via the Jak1/Stat1 signaling pathway.

STAT1 JAK1

6.36e-054114237080331
Pubmed

STS-1 promotes IFN-α induced autophagy by activating the JAK1-STAT1 signaling pathway in B cells.

STAT1 JAK1

6.36e-054114225959715
Pubmed

Constitutive activation of STAT transcription factors in acute myelogenous leukemia.

STAT1 JAK1

6.36e-054114211722592
Pubmed

Role of plasma membrane localization of the scaffold protein JSAP1 during differentiation of cerebellar granule cell precursors.

MAPK8IP3 MAPK1

6.36e-054114221156008
Pubmed

Kinesin-dependent axonal transport is mediated by the sunday driver (SYD) protein.

SPAG9 MAPK8IP3

6.36e-054114211106729
Pubmed

Pleiotrophin inhibits melanogenesis via Erk1/2-MITF signaling in normal human melanocytes.

MITF MAPK1

6.36e-054114225141921
Pubmed

Deficiency of the HGF/Met pathway leads to thyroid dysgenesis by impeding late thyroid expansion.

NKX2-1 MAPK1

6.36e-054114238605010
Pubmed

The Raf Kinase Inhibitor Sorafenib Inhibits JAK-STAT Signal Transduction in Human Immune Cells.

STAT1 JAK1

6.36e-054114226238487
Pubmed

In vivo CRISPR screening identifies Ptpn2 as a cancer immunotherapy target.

STAT1 JAK1

6.36e-054114228723893
Pubmed

Phosphorylation of smooth muscle 22α facilitates angiotensin II-induced ROS production via activation of the PKCδ-P47phox axis through release of PKCδ and actin dynamics and is associated with hypertrophy and hyperplasia of vascular smooth muscle cells in vitro and in vivo.

NCF1 JAK1

6.36e-054114222798525
Pubmed

Transcription factor protein interactomes reveal genetic determinants in heart disease.

ZBTB33 ZMYM2 BAZ1B MKNK1 UHRF1 TAF15 HSD17B4 HSPA6

6.57e-05411114835182466
InteractionMSN interactions

FLT4 NCF1 FAXC SEC31A WDFY4 F13A1 STAT1 AHCY VCL VAT1

1.04e-0533010710int:MSN
InteractionGATA4 interactions

ZBTB33 ZMYM2 BAZ1B SEC31A MKNK1 CORO2B UHRF1 TAF15 MAPK1 HSD17B4 HSPA6

1.19e-0541110711int:GATA4
Cytoband7q21.13

GTPBP10 CFAP69

2.18e-04911427q21.13
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

TANC2 ANK3 SGPP2 GRHL2 PPM1H SLC38A1 SCIN HYDIN

4.05e-0819711387e93a97b5ac5ae2f77a4b3141082a1463fed00dd
ToppCell10x5'v1-week_14-16-Myeloid_neutrophil-granulo-eo/baso/mast|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

DBI PPM1H DENND1B AHNAK NMT2 MITF HSD17B4 VAT1

4.21e-0819811382e6630eab77b12a6059682ab5ba465f38e469102
ToppCelldroplet-Lung-LUNG-30m-Epithelial|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PRMT8 ANK3 GRHL2 ITIH4 IQCA1 NKX2-1 HYDIN

3.39e-0717611375201f003192c033655ba47f0faf8c47a96eae03d
ToppCellLPS-IL1RA+antiTNF-Epithelial_alveolar-AT_2|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

TANC2 ANK3 SGPP2 GRHL2 SLC38A1 NKX2-1 FMN1

4.25e-07182113717ed11a7ea366dd3106400511d5e628d3f1a9c3e
ToppCelldroplet-Marrow-BM-1m-Myeloid-promonocyte|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

F13A1 EHD4 SULF2 AHNAK AHCY HSD17B4 PROS1

5.10e-071871137028e7d6e1211e123879d2f353dc32fae1185dd8e
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Cortical_Collecting_Duct_Principal_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

TANC2 ANK3 GRHL2 STAT1 SLC38A1 CORO2B SCIN

5.29e-071881137e30a4ddac0da8cdcf621d98e28e3895cd9307e7a
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

TANC2 ANK3 GRHL2 STAT1 SLC38A1 CORO2B SCIN

5.68e-07190113711d3c31167ea71809b4cc3757a0c6ea54a448602
ToppCelldroplet-Marrow-nan-21m-Myeloid-promonocyte|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

F13A1 EHD4 SULF2 AHNAK AHCY HSD17B4 PROS1

5.68e-0719011376c6d3259e23ec90c08756f500ae8a7aff8b8a5b3
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Principal_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

TANC2 SGPP2 GRHL2 SLC38A1 KIAA1549L SCIN PCDH9

5.88e-07191113796b78b4e819ea6052334bfcbc7abbf35897df885
ToppCell10x5'v1-week_14-16-Myeloid_neutrophil-granulo-eo/baso/mast-mast_cell|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

DBI PPM1H DENND1B AHNAK NMT2 MITF VAT1

6.53e-071941137d8f367beab16a3186821e42311947b6c9e99978c
ToppCell10x3'2.3-week_14-16-Myeloid_neutrophil-granulo-eo/baso/mast-mast_cell|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

DBI PPM1H DENND1B AHNAK NMT2 MITF VAT1

6.99e-07196113703710e2a843279124a45a271bffb132835e6081c
ToppCell10x3'2.3-week_14-16-Myeloid_neutrophil-granulo-eo/baso/mast|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

DBI PPM1H DENND1B AHNAK NMT2 MITF VAT1

7.24e-0719711375e4a004052b8560223673a339d4a0d729e533def
ToppCell10x5'v1-week_12-13-Myeloid_neutrophil-granulo-eo/baso/mast-mast_cell|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

PPM1H DENND1B AHNAK NMT2 MITF HSD17B4 VAT1

7.24e-07197113761f909737c5f630beffdd326c6844215643dbdde
ToppCell10x5'v1-week_12-13-Myeloid_neutrophil-granulo-eo/baso/mast|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

PPM1H DENND1B AHNAK NMT2 MITF HSD17B4 VAT1

7.49e-071981137a1247a5efd92f95c6227c0e71dc8a0427eb54b7f
ToppCell10x5'v1-week_12-13-Myeloid_neutrophil-granulo|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

NCF1 PPM1H DENND1B NMT2 MITF HSD17B4 VAT1

8.01e-072001137cad2d972aa6ea0cc9ebe5ec60fda6e306e9ee2b2
ToppCellfacs-Marrow-Granulocytes-3m-Myeloid-monocyte_+_promonocyte|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

F13A1 SULF2 AHNAK SLC49A3 DNA2 PROS1

5.69e-06175113669b59ec58e64644deb7e07f31ef495ef4a6f6276
ToppCellfacs-Marrow-Granulocytes-3m-Myeloid-promonocyte|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

F13A1 SULF2 AHNAK SLC49A3 DNA2 PROS1

5.69e-0617511364f7498b5a0ed52c348a5f94bcd41d830ba7954ea
ToppCelldroplet-Lung-30m-Epithelial-alveolar_epithelial|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

PRMT8 ANK3 SGPP2 GRHL2 ITIH4 NKX2-1

6.27e-06178113676e71fff99cf64302e2e3c0d66dd8ba0ff13624e
ToppCelldroplet-Lung-30m-Epithelial-alveolar_epithelial-type_II_pneumocyte-type_2_alveolar_epithelial_cell|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

PRMT8 ANK3 SGPP2 GRHL2 ITIH4 NKX2-1

6.27e-06178113682f78ea1ea3ff3e2347cd8bc2f06e2a10e96f220
ToppCelldroplet-Lung-30m-Epithelial|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

PRMT8 ANK3 SGPP2 GRHL2 ITIH4 NKX2-1

6.27e-0617811365442bc52b8e902da1383f44d97a9f95e471a8d4d
ToppCelldroplet-Lung-30m-Epithelial-alveolar_epithelial-type_II_pneumocyte|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

PRMT8 ANK3 SGPP2 GRHL2 ITIH4 NKX2-1

6.27e-061781136523b286ebe0359c7f1902f28cbd71f452626fc0d
ToppCelldroplet-Lung-3m-Epithelial-alveolar_epithelial-type_I_pneumocyte-type_1_alveolar_epithelial_cell|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

PRMT8 ANK3 SGPP2 GRHL2 ITIH4 NKX2-1

6.48e-061791136ca70a5518c5a5392e088c103e0cb44aa084f5332
ToppCelldroplet-Lung-3m-Epithelial-alveolar_epithelial-type_I_pneumocyte|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

PRMT8 ANK3 SGPP2 GRHL2 ITIH4 NKX2-1

6.48e-061791136c451b074b04eb5d6c575c6abaedda579c6744bbf
ToppCellLPS-antiTNF-Epithelial_alveolar-AT_2-AT2_Progenitor|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ANK3 SGPP2 DBI GRHL2 NKX2-1 FMN1

6.48e-0617911367db6b97a1c4c7a163d5da4351ba36ac1785d9d7b
ToppCell5'-GW_trimst-2-LargeIntestine-Hematopoietic-Myeloid-CLC+_Mast_cell|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PPM1H DENND1B SLC14A1 NMT2 MITF SLC49A3

6.90e-061811136338c7362d258a87f1a6b1a65376f5394d4b2b4b2
ToppCellTCGA-Skin-Metastatic-Melanoma-Skin_Cutaneous_Melanoma-2|TCGA-Skin / Sample_Type by Project: Shred V9

FAXC PPM1H ZZZ3 FMN1 MITF VAT1

6.90e-0618111369d5b331cabc5524f0a9fd8b571e87be4c447c7d4
ToppCelldroplet-Lung-nan-3m-Epithelial|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PRMT8 ANK3 GRHL2 ITIH4 NKX2-1 CFAP69

7.12e-061821136cfba75c1ffc39ac76db9e8e27394731942882b30
ToppCelldroplet-Lung-nan-3m-Epithelial-Alveolar_Epithelial_Type_2|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PRMT8 ANK3 GRHL2 ITIH4 NKX2-1 CFAP69

7.12e-061821136d836bfdc298ecd3558a973e393a329eb8bd59d79
ToppCelldroplet-Lung-nan-21m-Epithelial|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PRMT8 ANK3 SGPP2 SYT2 ITIH4 NKX2-1

7.12e-06182113640539ade8c3cd12b61f1cd0d493828e58282796b
ToppCelldroplet-Lung-nan-3m-Epithelial-type_II_pneumocyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PRMT8 ANK3 GRHL2 ITIH4 NKX2-1 CFAP69

7.12e-0618211367e7c7a26460d3003cdf0c0ffb96208a566aa09a7
ToppCellLPS-IL1RA+antiTNF-Epithelial_alveolar-AT_2-AT2_Progenitor|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

TANC2 ANK3 SGPP2 GRHL2 SLC38A1 NKX2-1

7.58e-061841136d0c212a8fbaad24597a84018442b25c61c17ea58
ToppCelldroplet-Lung-nan-21m-Epithelial-Alveolar_Epithelial_Type_2|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PRMT8 ANK3 SGPP2 SYT2 ITIH4 NKX2-1

7.82e-0618511366938ac3cab536cf8a474eba441ce6dcdfcc43b53
ToppCelldroplet-Lung-nan-21m-Epithelial-type_II_pneumocyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PRMT8 ANK3 SGPP2 SYT2 ITIH4 NKX2-1

7.82e-0618511360e7351cd6d6e6e8c29573042e168da50ee496cfc
ToppCelldroplet-Marrow-BM-30m-Myeloid-promonocyte|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

F13A1 EHD4 SULF2 AHNAK AHCY DNA2

8.06e-061861136bcb3ac9f9b51346e0a2b0bda96d149b3c11f7883
ToppCellLPS-IL1RA+antiTNF-Epithelial_alveolar-AT_2-Differentiating_AT2|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

TANC2 ANK3 SGPP2 GRHL2 SLC38A1 FMN1

8.06e-061861136e83718fabb057100835d3357df407f283d23fe16
ToppCelldroplet-Lung-LUNG-1m-Epithelial|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ANK3 ZNF750 IQCA1 NKX2-1 CFAP69 HYDIN

8.31e-0618711366288da8cdd450c58df00ebcfcc118f01fab7e610
ToppCellRV-04._Ventricular_Cardiomyocyte_I|RV / Chamber and Cluster_Paper

ANK3 CMYA5 DGLUCY MITF HADHB VCL

8.83e-0618911369c1debd65c13d63fd4f3158917d621b44b714c26
ToppCellPCW_07-8.5-Epithelial-Epithelial_airway-epi_proximal_progenitor1_(6)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

PRMT8 ANK3 GRHL2 PPM1H SLC38A1 NKX2-1

8.83e-0618911367659c7bbd58ee959a159294fb8d17317bbcc5681
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

TANC2 GRHL2 PPM1H PLEKHH2 PCDH9 HYDIN

9.10e-0619011363fc9e18c7441c0ae8cda65753cc42d0520f4e116
ToppCelldroplet-Lung-nan-18m-Epithelial|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PRMT8 ANK3 SGPP2 GRHL2 ITIH4 NKX2-1

9.10e-061901136b057bea6e55cef872290893b6e439bbcdcee2f2e
ToppCelldroplet-Marrow-nan-24m-Myeloid-promonocyte|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

F13A1 EHD4 AHNAK AHCY DNA2 PROS1

9.10e-061901136e2fdbfaf08da3274b6bdda615386aa880040a90a
ToppCellCOPD-Myeloid-cDC1|Myeloid / Disease state, Lineage and Cell class

APAF1 WDFY4 PPM1H SLC38A1 SULF2 DENND1B

9.38e-0619111363480e6d27dd4291765bbbb2acdb6a2e4f02c8085
ToppCelldroplet-Lung-18m-Epithelial|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

PRMT8 ANK3 SGPP2 GRHL2 ITIH4 NKX2-1

9.38e-0619111361b59f1cad6c1a6a5938afa9195164918e3ff4e86
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

TANC2 GRHL2 SLC38A1 CORO2B IQCA1 SCIN

9.66e-061921136fd08ae787e936cfdb1ab8f19b0fd63005b462709
ToppCellFetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_2|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

ANK3 SGPP2 GRHL2 NKX2-1 FMN1 SCIN

9.66e-061921136fb2f0e897228f808d9ff734ad05e9b49dc38fa50
ToppCelldroplet-Marrow-BM_(NON-STC)-30m-Myeloid-promonocyte|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DBI F13A1 EHD4 AHNAK AHCY PROS1

9.95e-0619311365a201ee6f132357c9aacfbad3ae56ed9854c25fd
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ANK3 SGPP2 GRHL2 PPM1H MITF SCIN

1.02e-0519411365eaaa81f4b2535f983c424aaef00077089526a5c
ToppCell10x3'2.3-week_17-19-Myeloid_neutrophil-granulo-eo/baso/mast|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

PPM1H DENND1B AHNAK MITF HSD17B4 VAT1

1.06e-051951136fbedb9978ded857fd35c2a8664f7579f42edaa36
ToppCellCOPD-Multiplet-Multiplet|COPD / Disease state, Lineage and Cell class

DNAH3 ANK3 SGPP2 GRHL2 CFAP69 HYDIN

1.09e-051961136af4cdc61830685a888a1209826c23bcf54a43084
ToppCellCOPD-Multiplet|COPD / Disease state, Lineage and Cell class

DNAH3 ANK3 SGPP2 GRHL2 CFAP69 HYDIN

1.09e-0519611366d02d494196e3f857d53eea46d9419690d43beca
ToppCellIPF-Epithelial|IPF / Disease state, Lineage and Cell class

DNAH3 ANK3 SGPP2 GRHL2 CFAP69 HYDIN

1.09e-05196113687d9881cfec461a5d89b688a83749b618c519485
ToppCell343B-Epithelial_cells-Epithelial-B_(AT2)|343B / Donor, Lineage, Cell class and subclass (all cells)

TANC2 ANK3 ACAT2 NKX2-1 PCDH9 COX14

1.12e-051971136f3ca63c7902d7530a29a85eb54f69b303031d150
ToppCell343B-Epithelial_cells-Epithelial-B_(AT2)-|343B / Donor, Lineage, Cell class and subclass (all cells)

TANC2 ANK3 ACAT2 NKX2-1 PCDH9 COX14

1.12e-051971136f98720cab066579fdac3ba24fb6fe4c5759dae4e
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-Degenerative_Endothelial_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

FLT4 ZBTB33 EHD4 SULF2 SLC49A3

4.88e-051561135ea9223bb6450b22df11efa1705ab72dab005244a
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-Degenerative_Endothelial_Cell-Degenerative_Peritubular_Capilary_Endothelial_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

FLT4 ZBTB33 EHD4 SULF2 SLC49A3

4.88e-051561135586b5509074c4cc359e9e31a968c2ded71c994ca
ToppCellfacs-Brain_Non-Myeloid-Hippocampus_-18m-Myeloid|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NCF1 FREM3 ITIH4 SERPINB11 SCIN

5.03e-0515711357fdc0094dd5729990a91a30c1982a14c74650b52
ToppCellfacs-Brain_Non-Myeloid-Hippocampus_-18m-Myeloid-microglial_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NCF1 FREM3 ITIH4 SERPINB11 SCIN

5.03e-051571135c762b03e254c73222094725ca8ac1c8eb428bccb
ToppCellfacs-Brain_Non-Myeloid-Hippocampus_-18m-Myeloid-nan|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NCF1 FREM3 ITIH4 SERPINB11 SCIN

5.03e-0515711356b5b08bb5520fcf6f4c0560f7ed7645ec179806d
ToppCellfacs-Marrow-B-cells-24m-Lymphocytic-precursor_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KIAA0408 SAXO1 KIAA1549L PLEKHH2 HYDIN

5.50e-051601135c381ec6be8cf887861cc18f831a20db42f953fe1
ToppCellfacs-Marrow-B-cells-24m-Lymphocytic-pre_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KIAA0408 SAXO1 KIAA1549L PLEKHH2 HYDIN

5.50e-05160113525c8f3d2a6d14ff0ca0b965fce89d3ff22f40585
ToppCellHealthy_Control-Lymphoid-B-|Healthy_Control / Condition, Lineage, Cell class and cell subclass

CNKSR2 SLC38A1 SULF2 SLC14A1 PCDH9

6.01e-051631135d84bd41b4494c7d5c7f88d511bfe481fb12f079d
ToppCell10x5'-Liver-Lymphocytic_Invariant-Inducer-like-ILC3|Liver / Manually curated celltypes from each tissue

CMYA5 PPM1H PLEKHH2 CFAP69 PCDH9

6.01e-0516311357f61483eeb1fde21843c6391468e13cb0cc2a89f
ToppCellfacs-Marrow-T_cells-18m-Myeloid-promonocyte|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

F13A1 SULF2 AHNAK SLC49A3 PROS1

6.01e-05163113530cd95d4f37bd54c1fde54960cb005db58bdd30c
ToppCellHealthy_Control-Lymphoid-B|Healthy_Control / Condition, Lineage, Cell class and cell subclass

CNKSR2 SLC38A1 SULF2 SLC14A1 PCDH9

6.01e-0516311350f723ec2503afa1b3ebb0754972438ffb6e6179d
ToppCellfacs-Marrow-T_cells-18m-Myeloid-monocyte_+_promonocyte|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

F13A1 SULF2 AHNAK SLC49A3 PROS1

6.01e-051631135ab934cb986495adfc8dbe5a276577f2a8fb6ee03
ToppCell367C-Epithelial_cells-Epithelial-A_(AT2)|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

ANK3 SPAG9 DBI SC5D NKX2-1

6.19e-051641135b0ed8cb6000ce8bf94444307e4b7b3574fa3fab2
ToppCell367C-Epithelial_cells-Epithelial-A_(AT2)-|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

ANK3 SPAG9 DBI SC5D NKX2-1

6.19e-0516411353aea6207a011ad55a1aeb2ed9fb54d31b23694b5
ToppCelldroplet-Lung-21m-Hematologic-myeloid-classical_monocyte-classical_monocyte_l2-17-52|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ANK3 F13A1 STAT1 ITIH4 DLG3

6.37e-051651135354978d4f35154d7b2e36e94de669e045adef512
ToppCellprimary_visual_cortex-Neuronal-GABAergic_neuron-Pvalb-Pvalb_Reln_Tac1|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

SYT2 FMN1 MITF ROM1 PLEKHH2

6.55e-05166113559d47c1fca7a8c70f6998f3367a9dbcb9b67966f
ToppCellTCGA-Brain-Primary_Tumor-Low_Grade_Glioma-Astrocytoma-9|TCGA-Brain / Sample_Type by Project: Shred V9

STAB2 SLC14A1 AHNAK ACSM5 HADHB

6.74e-051671135013971700e80b71e4b8c79b8fff0d8beeac295c3
ToppCell5'-Adult-SmallIntestine-Epithelial-Tuft-related-Tuft|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

TANC2 GDPD1 MINAR2 CMYA5 PPM1H

6.93e-0516811358072d0496b7b730c4601009eaa69ec5366d26d73
ToppCellCOVID-19-Heart-CM_+_Macrophage|Heart / Disease (COVID-19 only), tissue and cell type

CMYA5 WDFY4 F13A1 FMN1 MITF

7.33e-0517011354232fe937909f93d3736988c707b8f95ce993398
ToppCellfacs-Marrow-T-cells-3m-Myeloid-promonocyte|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

F13A1 SULF2 AHNAK DNA2 PROS1

7.33e-051701135a78d9789c3e7c84a36e1bd380192d7aba4a4d443
ToppCellfacs-Marrow-T-cells-3m-Myeloid-monocyte_+_promonocyte|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

F13A1 SULF2 AHNAK DNA2 PROS1

7.33e-051701135ff68600b945b3a5437b14e5411b3db800d0ccbe5
ToppCell3'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

DNAH3 PPM1H MAPK8IP3 CORO2B HYDIN

7.54e-0517111351854a777d9eb9d3fc3ed3632332a6f89ce8131da
ToppCellfacs-Lung-EPCAM-24m-Myeloid-Myeloid_Dendritic_Type_1|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NCF1 WDFY4 SLC38A1 SULF2 DNA2

7.75e-051721135cabe7b4131d72da87d3caacd8cced3a4f2cbef53
ToppCell10x3'2.3-week_14-16-Hematopoietic-HSC/MPP_and_pro-eo/baso/mast_precursor|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

MINAR2 PPM1H DENND1B NMT2 VAT1

7.75e-0517211357fb43b3938b9a3b6935ec22d9d853e7d47b82b3c
ToppCelldroplet-Marrow-nan-18m-Myeloid-monocyte|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DBI F13A1 EHD4 SULF2 AHNAK

8.40e-051751135510c46bfd250ef83fcad8f6b01efbcca9d71a9a2
ToppCell390C-Lymphocytic-NK_cells-NK_cell_A2|NK_cells / Donor, Lineage, Cell class and subclass (all cells)

ACAT2 APAF1 SULF2 TXNDC16 PCDH9

8.40e-051751135da191dfb8a7f976a632a3a0b923942ab54f5c8c1
ToppCelldroplet-Marrow-BM_(NON-STC)-30m-Myeloid-monocyte|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DBI F13A1 EHD4 AHNAK PROS1

8.63e-0517611351bf8fed48bd224f09efe90a38233b1f01d7311fe
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

GRHL2 PPM1H DNAH17 PLEKHH2 HYDIN

8.63e-051761135327a3e81b724252e36d786de92a3ffd721ea6d7b
ToppCelldroplet-Liver-LIVER_HEP-30m-Myeloid-Kupffer_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NCF1 GRHL2 STAT1 DENND1B DNAH17

8.63e-0517611355e46a09a36b9645b1b1fcb0b64bd0898561af3a9
ToppCellTCGA-Liver-Primary_Tumor-Hepatocellular_Carcinoma-Hepatocellular_Carcinoma-1|TCGA-Liver / Sample_Type by Project: Shred V9

FAXC GRHL2 KIAA1549L FMN1 DLG3

9.10e-05178113551c59dabf2d7aef1b1964f6f766d5ec07ef90f5a
ToppCellLPS_only-Epithelial_alveolar-AT_2-Differentiating_AT2|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

TANC2 ANK3 SGPP2 GRHL2 FMN1

9.35e-051791135fd2cbee532e7b44113410dca82aec7db1a7fb69f
ToppCell5'-GW_trimst-2-LargeIntestine-Hematopoietic-B_cells-Pre-B|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

NCF1 WDFY4 IGLV4-69 PCDH9 HSPA6

9.35e-051791135dc0b806904ef4c2f74f34ade2b1c0d6893f3b2ec
ToppCellLPS-antiTNF-Epithelial_alveolar-AT_2|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ANK3 SGPP2 GRHL2 NKX2-1 FMN1

9.60e-051801135b798a3fa2dd15b68aa4267f665559527043dcc07
ToppCellsevere-CD8+_T_naive|severe / disease stage, cell group and cell class

ANK3 ZNF430 MVB12A SLC14A1 CDK3

9.60e-05180113594fe530367b170777f4051a4034cff06d80dbb83
ToppCelldroplet-Lung-LUNG-30m-Epithelial-type_II_pneumocyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PRMT8 ANK3 SGPP2 ITIH4 NKX2-1

9.85e-051811135cadb18fc73031eb9f779599e15cd7861337fee78
ToppCellLPS_only-Epithelial_alveolar-AT_2-AT2_Progenitor|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ANK3 SGPP2 GRHL2 NKX2-1 FMN1

9.85e-0518111350513b9e6673ff7bf8e72ba123ca3794b65d10170
ToppCelldroplet-Lung-LUNG-30m-Epithelial-Alveolar_Epithelial_Type_2|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PRMT8 ANK3 SGPP2 ITIH4 NKX2-1

9.85e-05181113585bec4d3f255f4c61c790325eeb50ad38f709ef2
ToppCellASK454-Epithelial|ASK454 / Donor, Lineage and Cell class of Lung cells from Dropseq

KIAA0408 PRMT8 GRHL2 NKX2-1 HYDIN

1.01e-041821135ab15316cff989b61ff397a866d7ca8b49c13e981
ToppCellLPS-antiTNF-Epithelial_alveolar-AT_2-AT2|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ANK3 SGPP2 GRHL2 NKX2-1 FMN1

1.01e-0418211351e2149b222a3e9f64841aed45288a6f29394e7b0
ToppCelldroplet-Lung-LUNG-30m-Epithelial-ciliated_columnar_cell_of_tracheobronchial_tree|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GRHL2 ZNF750 IQCA1 CFAP69 HYDIN

1.04e-0418311353991830726d05cf19606d540de04093985b7bdeb
ToppCelldroplet-Lung-LUNG-30m-Epithelial-Ciliated_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GRHL2 ZNF750 IQCA1 CFAP69 HYDIN

1.04e-041831135cc844f54c7564bf432b179ca63bc7c4b9b8cfdd9
ToppCellLPS_only-Epithelial_alveolar-AT_2|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ANK3 SGPP2 GRHL2 NKX2-1 FMN1

1.04e-041831135e972432dd4d1bd31bb0982f4df3061e5e152658f
ToppCellCOVID-19-Epithelial_cells-AT2|COVID-19 / group, cell type (main and fine annotations)

ANK3 SGPP2 GRHL2 NKX2-1 PCDH9

1.06e-041841135369b82f793deab672204558ae4e112cfa5aa9ccc
ToppCellCOPD-Myeloid-cDC1|World / Disease state, Lineage and Cell class

APAF1 WDFY4 PPM1H SULF2 DENND1B

1.06e-04184113542d7ce104cd7bcb83fbbbd0e7d3267ad07edfa94
ToppCellfacs-Lung-EPCAM-18m-Epithelial-type_II_pneumocyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PRMT8 ANK3 SGPP2 ITIH4 NKX2-1

1.06e-04184113504bd8ab5808fcfa923aa4d0edf6a7f88b7980122
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_C_(IT_L4_RORB)|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CNKSR2 SYT2 CMYA5 FMN1 PLEKHH2

1.06e-0418411356475a43201b136dcc9b113d2ca4cfa154ed9d65d
ToppCellLV-15._Ventricular_Cardiomyocyte_III|LV / Chamber and Cluster_Paper

ANK3 CMYA5 MITF PCDH9 VCL

1.06e-041841135ab7a1620c14a9d9b6be1b47c559931e345e9eef8
Drug2-methyl-3-hydroxybutyryl-CoA

ACAT2 DLG3 HADHB HSD17B4

4.57e-06231124CID000000052
Drugphenethyl isothiocyanate

CYP1A2 ACAT2 APAF1 LARS1 BAZ1B STAT1 JAK1 FANCI MAPK1 PLEKHH2 PROS1

4.71e-0640111211ctd:C058305
Diseasesensory perception of smell

STAB2 PPM1H PCDH9

1.76e-04291113GO_0007608
DiseaseThrombophilia due to thrombin defect

F13A1 PROS1

3.87e-0481112cv:C3160733
DiseaseX-17676 measurement

DNAH3 ACSM5

3.87e-0481112EFO_0800785
Diseaseadvanced glycation end-product measurement

CYP1A2 SLC38A1

4.96e-0491112EFO_0007819
Diseasecancer (implicated_via_orthology)

FLT4 PIP5K1A DLG3 MAPK1 DNA2 CDK3

5.42e-042681116DOID:162 (implicated_via_orthology)
Diseaseurinary bladder carcinoma

SLC38A1 SLC14A1 FMN1

7.45e-04471113MONDO_0004986
Disease1-methylxanthine measurement

CYP1A2 SLC38A1

7.54e-04111112EFO_0021174
Disease5-acetylamino-6-amino-3-methyluracil measurement

CYP1A2 SLC38A1

7.54e-04111112EFO_0800951
Diseaselipid metabolism disorder (implicated_via_orthology)

HADHB HSD17B4

1.43e-03151112DOID:3146 (implicated_via_orthology)
Diseaselow affinity immunoglobulin gamma Fc region receptor II-a measurement

HSPA6 HSPA7

1.84e-03171112EFO_0021969
Diseaseneuroimaging measurement

CYP1A2 ANK3 CNKSR2 STAT1 MAPK8IP3 JAK1 SULF2 DENND1B MITF AHCY UQCC1

2.34e-03106911111EFO_0004346
DiseaseConventional (Clear Cell) Renal Cell Carcinoma

FLT4 APAF1 AHNAK MITF

2.40e-031481114C0279702
Diseasechildhood trauma measurement, alcohol consumption measurement

TANC2 CNKSR2 PCDHGB4

2.46e-03711113EFO_0007878, EFO_0007979
Diseaseprostate adenocarcinoma (is_implicated_in)

STAT1 MAPK1

2.55e-03201112DOID:2526 (is_implicated_in)
Diseaseelectroencephalogram measurement

DNAH3 CMYA5 MITF

2.77e-03741113EFO_0004357
Diseasestem Cell Growth Factor beta measurement

STAB2 PCDH9 PNLIPRP3

2.87e-03751113EFO_0008292
Diseasenon-small cell lung carcinoma

CYP1A2 SAXO1 HADHB

2.87e-03751113EFO_0003060
DiseaseJT interval, response to sulfonylurea

STAT1 HSD17B4

3.37e-03231112EFO_0007885, EFO_0007922
DiseaseAnhedonia

ANK3 MAPK1

3.67e-03241112C0178417
Diseaselow density lipoprotein cholesterol measurement, response to escitalopram, response to citalopram

GRHL2 SULF2

3.67e-03241112EFO_0004611, EFO_0006329, EFO_0007871
Diseasechildhood trauma measurement

CNKSR2 PCDH9

3.67e-03241112EFO_0007979

Protein segments in the cluster

PeptideGeneStartEntry
SPDGKMLISAGGYIK

APAF1

1186

O14727
PREEMVLSGKYKSGE

ACTR6

251

Q9GZN1
LSIYETPSMGLLDKK

EIF3B

446

P55884
MPTGKQLADIGYKTF

COX14

1

Q96I36
YGELGMKLSEIPLTL

BAZ1B

671

Q9UIG0
KGEYDMTVPKLEGDL

AHNAK

961

Q09666
KIKSGSMGKASPPYD

ACSM5

386

Q6NUN0
IYQGKLPTTGMTITK

ARHGEF7

521

Q14155
GEEIYGTISMKPNAK

PRMT8

351

Q9NR22
GIDTSDMKYPVKSIP

IQCA1

146

Q86XH1
TYATPKVLEKAGLTM

HADHB

356

P55084
IDGMTYPGIIKEKAE

ITIH4

86

Q14624
ILSPLEESYKKVGME

NKX2-1

16

P43699
TGKPMINLYTDKDTG

TAF15

266

Q92804
GVKVDLTPIYGLTMK

CYP1A2

486

P05177
GMKPKSGEKEITPSY

FMN1

1336

Q68DA7
MEFLPSGSLKEYLPK

JAK1

956

P23458
TKLSPISVLYKDDMG

GDF2

396

Q9UK05
ISVLYKDDMGVPTLK

GDF2

401

Q9UK05
EKGPRYLMKLNSDGS

IGLV4-69

61

A0A075B6H9
SDGSKYPEMVLKTPL

PCDHGB4

186

Q9UN71
VDIEPYVSKMLGTGK

SPAG9

1126

O60271
DKKYIMGPKLSTLDA

FAXC

276

Q5TGI0
GFILMDSYGPKKVLD

FANCI

386

Q9NVI1
PEIMLNSKGYTKSID

MAPK1

196

P28482
SGKLEPGMTYTKLID

PNLIPRP3

391

Q17RR3
GPRAYAETSKMKVLE

MAGEB2

276

O15479
DIEPYVSKMLGTGKL

MAPK8IP3

1126

Q9UPT6
MKLYRLPDVTKTSGL

NMT2

326

O60551
TIPAMKDDGIGYKVD

ZBTB33

606

Q86T24
LMTLKGLPSTYNKDL

ASL

311

P04424
KKKTSEDIMLVYPAG

FSIP2

336

Q5CZC0
KLMIYEGSKRPSGVS

IGLV2-23

66

P01705
VPKMAADYLTGSKAI

OR2T8

76

A6NH00
LGDMYTPGFDTLLKK

MINAR2

141

P59773
DTYVMKIKVEDGGTP

PCDH9

216

Q9HC56
PETYLMPKDGKSTAT

NCF1

136

P14598
GQEMTTEELTKPGKY

FAM47B

366

Q8NA70
SMLYPNEGKTSKDGI

KIAA0408

321

Q6ZU52
ETALMYGAKKPLNTE

F13A1

496

P00488
DLGATGVMTDYPTKL

GDPD1

291

Q8N9F7
KPMILLVGQYSTGKT

EHD4

61

Q9H223
VYDSLTIGDMKKPAT

KIAA1549L

381

Q6ZVL6
VPKMAADYLTGSKAI

OR2T33

76

Q8NG76
SLVPYASGMPIKKIG

PIP5K1A

51

Q99755
NEPLEKSGYLLKMSG

PLEKHH2

701

Q8IVE3
LSKMKETAEAYLGQP

HSPA7

126

P48741
GKTKTVPGYLRIGDM

MVB12A

126

Q96EY5
EGKKLLSLSYTVMTP

OR10A2

256

Q9H208
DLKKYMDSTPGSELP

CDK3

86

Q00526
KPDLSITMKGLDYID

HYDIN

4771

Q4G0P3
TTLKPELGKIMYSDF

GTPBP10

181

A4D1E9
KGLMEAISEKYGLPV

GRHL2

561

Q6ISB3
DPVLMSLKEGYKKSS

CORO2B

391

Q9UQ03
ARMGLTKPLKEGDYD

DNAH17

1106

Q9UFH2
DASDKPLKVGLGMYS

DNAH17

1621

Q9UFH2
DPMGGKTSAYKVLAA

DNAH3

1711

Q8TD57
MYALGVGASIKDPKD

HSD17B4

346

P51659
DRKSPLILKGVSEYM

CMYA5

716

Q8N3K9
LKTKPSDEEMLFIYG

DBI

16

P07108
MTGDTDKYLGPQDLK

ANK3

876

Q12955
TSDMVYLKVAKPGSL

DLG3

301

Q92796
RKKLYVSPGTMDGGL

GJB7

106

Q6PEY0
LSKMKETAEAYLGQP

HSPA6

126

P17066
GIKELSKPAYGDAMV

DGLUCY

201

Q7Z3D6
VMKTDPRKLQSGLGY

CFAP69

566

A5D8W1
KDYTLIVGMPGTGKT

DNA2

641

P51530
RVKTPYSGEMDLLGE

DENND1B

556

Q6P3S1
MSDKLPYKVADIGLA

AHCY

1

P23526
PKGAFTGLYSLKVLM

LGR5

106

O75473
IGSTIETGLMLKLPY

OR8A1

171

Q8NGG7
PGKFEDMYKLTSELL

MKNK1

41

Q9BUB5
GYLEKIASAPGSKMS

FREM3

1116

P0C091
NLKKMDVGGLSDPYV

SYT2

296

Q8N9I0
KEKGMTFLPTTVSGL

HHLA1

36

C9JL84
MELDGPKGTGYIKTE

STAT1

691

P42224
KQSYRGLMGEPAKSL

SAXO1

241

Q8IYX7
LKSAKMYLETDPSGR

SCIN

671

Q9Y6U3
VIASELGSMPELKKY

LARS1

971

Q9P2J5
IVSSVMKIPSAGGKY

OR7G3

221

Q8NG95
VTGKELRYEGLMGKP

HDHD5

266

Q9BXW7
KPDYGDTIVSFLSKM

TANC2

551

Q9HCD6
DLSGMSPTKGLYLSK

SERPINB11

316

Q96P15
PEGGKMSQYLDSLKV

CYB5R1

126

Q9UHQ9
MKAKVATYLGGLPDV

PROS1

611

P07225
KLEKRLIAEYGMPST

SGPP2

151

Q8IWX5
IKPSEGLGMYIKSTY

CNKSR2

221

Q8WXI2
VKKGEDIPLMLGVYT

SLC49A3

186

Q6UXD7
VKTEGRMKLYSGLPA

UCP1

66

P25874
KISSTKGLGAISPYM

ZNF750

221

Q32MQ0
MKKYGSLVPLSEKEV

SENP5

511

Q96HI0
PVSYAGMLGTEDLLK

TXNDC16

476

Q9P2K2
YSVPTKMGSKLEDIL

MITF

471

O75030
MSKLKPYFLTDGTGT

ACAT2

231

Q9BWD1
TQGYLFPSGLKDMLK

ROM1

306

Q03395
PLIYGEGKKARVMAT

PPM1H

371

Q9ULR3
LKRMSVTEGGIKYPE

POLR2A

31

P24928
ADIKTGYLSIIMDPG

FLT4

806

P35916
DLVTYTKNLGPGMTK

VCL

156

P18206
KDMYLFSLGSESPKG

WDFY4

2861

Q6ZS81
MKDGTLDYLLSPEGS

STAB2

566

Q8WWQ8
IIEAMGFTGPLKYSK

UQCC1

96

Q9NVA1
FPKALGYVTGDMKEL

SLC14A1

31

Q13336
DSFLMQPEKYGKLTT

ZMYM2

521

Q9UBW7
MENLKSGVYPLKEAS

ZNF430

1

Q9H8G1
DRIKKLGLTMQYPEG

UHRF1

596

Q96T88
KVVTYGMANLLTGPK

VAT1

281

Q99536
TVTLKLGGYEPLFTM

PIEZO1

2211

Q92508
PYKMDSKGDVSGVLI

SEC31A

76

O94979
EGKGPLSYVKEMTEG

SC5D

261

O75845
KKDGESLSYSMLPLS

ZZZ3

611

Q8IYH5
KKCDEYIPGTTSLGM

SLC38A1

61

Q9H2H9
GLVKGKSMPYEFDIR

SULF2

326

Q8IWU5
YKTLMSLDAEGSVPK

ZNF282

231

Q9UDV7
KEVMYKIITGKPSGA

TBK1

231

Q9UHD2
GISIKPLYSKRDTMD

MMUT

66

P22033