Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	microfilament motor activity	MYH1 MYH4 MYH8 MYH7B	1.57e-06	38	45	4	GO:0000146
GeneOntologyMolecularFunction	intracellular sodium-activated potassium channel activity	KCNT2 KCNT1	4.97e-06	2	45	2	GO:0005228
GeneOntologyMolecularFunction	copper ion binding	HEPHL1 ADNP LACC1 F8	2.84e-05	78	45	4	GO:0005507
GeneOntologyMolecularFunction	cytoskeletal motor activity	MYH1 MYH4 MYH8 MYH7B	1.43e-04	118	45	4	GO:0003774
GeneOntologyMolecularFunction	pentosyltransferase activity	POGLUT2 LACC1 TIPARP	2.73e-04	56	45	3	GO:0016763
GeneOntologyMolecularFunction	outward rectifier potassium channel activity	KCNT2 KCNT1	1.68e-03	27	45	2	GO:0015271
GeneOntologyMolecularFunction	actin filament binding	MYH1 MYH4 MYH8 MYH7B	1.68e-03	227	45	4	GO:0051015
GeneOntologyMolecularFunction	monoatomic ion-gated channel activity	KCNT2 KCNT1	2.22e-03	31	45	2	GO:0022839
GeneOntologyCellularComponent	myosin filament	MYH1 MYH4 MYH8 MYH7B	2.29e-07	25	45	4	GO:0032982
GeneOntologyCellularComponent	myosin II complex	MYH1 MYH4 MYH8 MYH7B	3.69e-07	28	45	4	GO:0016460
GeneOntologyCellularComponent	muscle myosin complex	MYH1 MYH4 MYH8	5.12e-06	16	45	3	GO:0005859
GeneOntologyCellularComponent	myosin complex	MYH1 MYH4 MYH8 MYH7B	7.82e-06	59	45	4	GO:0016459
Domain	Myosin_N	MYH1 MYH4 MYH8 MYH7B	3.26e-08	15	43	4	IPR004009
Domain	Myosin_N	MYH1 MYH4 MYH8 MYH7B	3.26e-08	15	43	4	PF02736
Domain	Myosin_tail_1	MYH1 MYH4 MYH8 MYH7B	7.28e-08	18	43	4	PF01576
Domain	Myosin_tail	MYH1 MYH4 MYH8 MYH7B	7.28e-08	18	43	4	IPR002928
Domain	Myosin-like_IQ_dom	MYH1 MYH4 MYH8 MYH7B	9.20e-08	19	43	4	IPR027401
Domain	-	MYH1 MYH4 MYH8 MYH7B	9.20e-08	19	43	4	4.10.270.10
Domain	MYOSIN_MOTOR	MYH1 MYH4 MYH8 MYH7B	1.70e-06	38	43	4	PS51456
Domain	Myosin_head	MYH1 MYH4 MYH8 MYH7B	1.70e-06	38	43	4	PF00063
Domain	Myosin_head_motor_dom	MYH1 MYH4 MYH8 MYH7B	1.70e-06	38	43	4	IPR001609
Domain	MYSc	MYH1 MYH4 MYH8 MYH7B	1.70e-06	38	43	4	SM00242
Domain	-	EFNB1 HEPHL1 F8	4.07e-06	14	43	3	2.60.40.420
Domain	Cupredoxin	EFNB1 HEPHL1 F8	1.70e-05	22	43	3	IPR008972
Domain	Cu-oxidase_2	HEPHL1 F8	3.10e-05	4	43	2	IPR011706
Domain	K_chnl_Ca-activ_BK_asu	KCNT2 KCNT1	3.10e-05	4	43	2	IPR003929
Domain	BK_channel_a	KCNT2 KCNT1	3.10e-05	4	43	2	PF03493
Domain	Cu-oxidase_2	HEPHL1 F8	3.10e-05	4	43	2	PF07731
Domain	IQ	MYH1 MYH4 MYH8 MYH7B	3.56e-05	81	43	4	SM00015
Domain	Cu-oxidase_3	HEPHL1 F8	5.15e-05	5	43	2	IPR011707
Domain	Cu_oxidase_CS	HEPHL1 F8	5.15e-05	5	43	2	IPR033138
Domain	MULTICOPPER_OXIDASE1	HEPHL1 F8	5.15e-05	5	43	2	PS00079
Domain	Cu-oxidase_3	HEPHL1 F8	5.15e-05	5	43	2	PF07732
Domain	IQ_motif_EF-hand-BS	MYH1 MYH4 MYH8 MYH7B	5.39e-05	90	43	4	IPR000048
Domain	IQ	MYH1 MYH4 MYH8 MYH7B	6.13e-05	93	43	4	PS50096
Domain	Cu_oxidase_Cu_BS	HEPHL1 F8	7.72e-05	6	43	2	IPR002355
Domain	IQ	MYH1 MYH4 MYH8	5.83e-04	71	43	3	PF00612
Domain	K_chnl_dom	KCNT2 KCNT1	1.06e-03	21	43	2	IPR013099
Domain	Ion_trans_2	KCNT2 KCNT1	1.06e-03	21	43	2	PF07885
Pathway	KEGG_VIRAL_MYOCARDITIS	MYH1 MYH4 MYH8 HLA-DPA1 MYH7B	3.38e-07	70	30	5	M12294
Pathway	KEGG_TIGHT_JUNCTION	MYH1 MYH4 MYH8 MYH7B	1.67e-04	132	30	4	M11355
Pubmed	Three linked myosin heavy chain genes clustered within 370 kb of each other show independent transcriptional and post-transcriptional regulation during differentiation of a mouse muscle cell line.	MYH1 MYH4 MYH8	8.09e-09	4	45	3	1985022
Pubmed	Developmental pattern of mouse skeletal myosin heavy chain gene transcripts in vivo and in vitro.	MYH1 MYH4 MYH8	2.02e-08	5	45	3	3829126
Pubmed	Sequential accumulation of mRNAs encoding different myosin heavy chain isoforms during skeletal muscle development in vivo detected with a recombinant plasmid identified as coding for an adult fast myosin heavy chain from mouse skeletal muscle.	MYH1 MYH4 MYH8	2.02e-08	5	45	3	6196357
Pubmed	Myosin heavy chain isoforms of the murine masseter muscle during pre- and post-natal development.	MYH1 MYH4 MYH8	2.02e-08	5	45	3	12919077
Pubmed	Organization of human and mouse skeletal myosin heavy chain gene clusters is highly conserved.	MYH1 MYH4 MYH8	4.04e-08	6	45	3	10077619
Pubmed	Distinct myogenic programs of embryonic and fetal mouse muscle cells: expression of the perinatal myosin heavy chain isoform in vitro.	MYH1 MYH4 MYH8	4.04e-08	6	45	3	1728586
Pubmed	Spatial and temporal changes in myosin heavy chain gene expression in skeletal muscle development.	MYH1 MYH4 MYH8	4.04e-08	6	45	3	10588881
Pubmed	A fast Myosin super enhancer dictates muscle fiber phenotype through competitive interactions with Myosin genes.	MYH1 MYH4 MYH8	7.06e-08	7	45	3	35210422
Pubmed	Diversity in transcriptional start site selection and alternative splicing affects the 5'-UTR of mouse striated muscle myosin transcripts.	MYH1 MYH4 MYH8	7.06e-08	7	45	3	16819597
Pubmed	Genes for skeletal muscle myosin heavy chains are clustered and are not located on the same mouse chromosome as a cardiac myosin heavy chain gene.	MYH1 MYH4 MYH8	1.13e-07	8	45	3	3864153
Pubmed	During muscle atrophy, thick, but not thin, filament components are degraded by MuRF1-dependent ubiquitylation.	MYH1 MYH4 MYH8	2.41e-07	10	45	3	19506036
Pubmed	Modulation of contractile protein gene expression in fetal murine crural muscles: emergence of muscle diversity.	MYH1 MYH4 MYH8	3.32e-07	11	45	3	8136524
Pubmed	Contractile protein gene expression in primary myotubes of embryonic mouse hindlimb muscles.	MYH1 MYH4 MYH8	5.74e-07	13	45	3	8404542
Pubmed	Defective excitation-contraction coupling is partially responsible for impaired contractility in hindlimb muscles of Stac3 knockout mice.	MYH1 MYH4 MYH8	7.29e-07	14	45	3	27184118
Pubmed	A family of microRNAs encoded by myosin genes governs myosin expression and muscle performance.	MYH1 MYH4 MYH7B	1.12e-06	16	45	3	19922871
Pubmed	Cell volume changes regulate slick (Slo2.1), but not slack (Slo2.2) K+ channels.	KCNT2 KCNT1	1.64e-06	2	45	2	25347289
Pubmed	Postnatal myosin heavy chain isoform expression in normal mice and mice null for IIb or IId myosin heavy chains.	MYH1 MYH4	1.64e-06	2	45	2	11150240
Pubmed	Differential distribution of the sodium-activated potassium channels slick and slack in mouse brain.	KCNT2 KCNT1	1.64e-06	2	45	2	26587966
Pubmed	Molecular mechanisms of Slo2 K+ channel closure.	KCNT2 KCNT1	1.64e-06	2	45	2	27682982
Pubmed	Sodium-activated potassium channels shape peripheral auditory function and activity of the primary auditory neurons in mice.	KCNT2 KCNT1	1.64e-06	2	45	2	30796290
Pubmed	Five skeletal myosin heavy chain genes are organized as a multigene complex in the human genome.	MYH4 MYH8	1.64e-06	2	45	2	8518795
Pubmed	Cardiac Slo2.1 Is Required for Volatile Anesthetic Stimulation of K+ Transport and Anesthetic Preconditioning.	KCNT2 KCNT1	1.64e-06	2	45	2	26845140
Pubmed	Slack and Slick K(Na) channels regulate the accuracy of timing of auditory neurons.	KCNT2 KCNT1	1.64e-06	2	45	2	17344399
Pubmed	Skeletal muscle adaptations in response to voluntary wheel running in myosin heavy chain null mice.	MYH1 MYH4	1.64e-06	2	45	2	11744674
Pubmed	Growth and muscle defects in mice lacking adult myosin heavy chain genes.	MYH1 MYH4	1.64e-06	2	45	2	9382868
Pubmed	A new role for the calcineurin/NFAT pathway in neonatal myosin heavy chain expression via the NFATc2/MyoD complex during mouse myogenesis.	MYH1 MYH4 MYH8	3.06e-06	22	45	3	24301466
Pubmed	Transition of myosin heavy chain isoforms in human laryngeal abductors following denervation.	MYH1 MYH4	4.91e-06	3	45	2	26059207
Pubmed	Simultaneous loss of skeletal muscle myosin heavy chain IIx and IIb causes severe skeletal muscle hypoplasia in postnatal mice.	MYH1 MYH4	4.91e-06	3	45	2	36515178
Pubmed	Knockout of Slo2.2 enhances itch, abolishes KNa current, and increases action potential firing frequency in DRG neurons.	KCNT2 KCNT1	4.91e-06	3	45	2	26559620
Pubmed	Genome-wide mapping of Sox6 binding sites in skeletal muscle reveals both direct and indirect regulation of muscle terminal differentiation by Sox6.	MYH1 MYH4 MYH7B	8.87e-06	31	45	3	21985497
Pubmed	Comparative sequence analysis of the complete human sarcomeric myosin heavy chain family: implications for functional diversity.	MYH1 MYH4	9.81e-06	4	45	2	10388558
Pubmed	Smooth muscle myosin light chain kinase expression in cardiac and skeletal muscle.	MYH1 MYH4	9.81e-06	4	45	2	11029314
Pubmed	Two novel/ancient myosins in mammalian skeletal muscles: MYH14/7b and MYH15 are expressed in extraocular muscles and muscle spindles.	MYH4 MYH7B	9.81e-06	4	45	2	19948655
Pubmed	Evaluation of embryonic and perinatal myosin gene mutations and the etiology of congenital idiopathic clubfoot.	MYH1 MYH8	9.81e-06	4	45	2	20357587
Pubmed	A human YAC transgene rescues craniofacial and neural tube development in PDGFRalpha knockout mice and uncovers a role for PDGFRalpha in prenatal lung growth.	MYH1 MYH4	9.81e-06	4	45	2	11023856
Pubmed	Modulation of skeletal muscle fiber type by mitogen-activated protein kinase signaling.	MYH1 MYH4	9.81e-06	4	45	2	18417546
Pubmed	Human MYO18B, a novel unconventional myosin heavy chain expressed in striated muscles moves into the myonuclei upon differentiation.	MYH1 MYH4	9.81e-06	4	45	2	12547197
Pubmed	Myosin heavy chain-embryonic regulates skeletal muscle differentiation during mammalian development.	MYH1 MYH4 MYH8	1.07e-05	33	45	3	32094117
Pubmed	Detection of Gene and Protein Expression in Mouse Embryos and Tissue Sections.	MYH1 MYH4	1.63e-05	5	45	2	30737693
Pubmed	Temporal regulation of the Mediator complex during muscle proliferation, differentiation, regeneration, aging, and disease.	MYH1 MYH4 MYH8	1.79e-05	39	45	3	38690566
Pubmed	∆F508 CFTR interactome remodelling promotes rescue of cystic fibrosis.	MYH1 NCBP1 MYH4 ATP5MF MYH8 MYH7B TECR	1.83e-05	647	45	7	26618866
Pubmed	A hypoplastic model of skeletal muscle development displaying reduced foetal myoblast cell numbers, increased oxidative myofibres and improved specific tension capacity.	MYH1 MYH4	2.45e-05	6	45	2	20417199
Pubmed	A role for Insulin-like growth factor 2 in specification of the fast skeletal muscle fibre.	MYH1 MYH4	2.45e-05	6	45	2	17559643
Pubmed	HOXA5 plays tissue-specific roles in the developing respiratory system.	MYH1 MYH4 MYH8	2.96e-05	46	45	3	28827394
Pubmed	A hypomorphic myogenin allele reveals distinct myogenin expression levels required for viability, skeletal muscle development, and sternum formation.	MYH4 MYH8	3.42e-05	7	45	2	10075840
Pubmed	ANKK1 is found in myogenic precursors and muscle fibers subtypes with glycolytic metabolism.	MYH1 MYH4	3.42e-05	7	45	2	29758057
Pubmed	Neuromuscular junction immaturity and muscle atrophy are hallmarks of the ColQ-deficient mouse, a model of congenital myasthenic syndrome with acetylcholinesterase deficiency.	MYH1 MYH4	4.56e-05	8	45	2	26993635
Pubmed	Long noncoding RNA lncMREF promotes myogenic differentiation and muscle regeneration by interacting with the Smarca5/p300 complex.	MYH1 MYH4	4.56e-05	8	45	2	36200826
Pubmed	International Union of Pharmacology. LII. Nomenclature and molecular relationships of calcium-activated potassium channels.	KCNT2 KCNT1	4.56e-05	8	45	2	16382103
Pubmed	Cell lineage- and expression-based inference of the roles of forkhead box transcription factor Foxc2 in craniofacial development.	MYH1 MYH4	4.56e-05	8	45	2	33667029
Pubmed	A Tcf4-positive mesodermal population provides a prepattern for vertebrate limb muscle patterning.	MYH1 MYH4	4.56e-05	8	45	2	14667415
Pubmed	GASP-2 overexpressing mice exhibit a hypermuscular phenotype with contrasting molecular effects compared to GASP-1 transgenics.	MYH1 MYH4	5.86e-05	9	45	2	31960486
Pubmed	Genesis of muscle fiber-type diversity during mouse embryogenesis relies on Six1 and Six4 gene expression.	MYH1 MYH4 MYH8	5.94e-05	58	45	3	21884692
Pubmed	The expression of myosin genes in developing skeletal muscle in the mouse embryo.	MYH4 MYH8	7.32e-05	10	45	2	2211821
Pubmed	Acceleration of somitic myogenesis in embryos of myogenin promoter-MRF4 transgenic mice.	MYH1 MYH8	7.32e-05	10	45	2	8950513
Pubmed	Deletion of the protein kinase A/protein kinase G target SMTNL1 promotes an exercise-adapted phenotype in vascular smooth muscle.	MYH1 MYH4	8.94e-05	11	45	2	18310078
Pubmed	Extracellular matrix protein composition dynamically changes during murine forelimb development.	MYH1 MYH4	8.94e-05	11	45	2	38303699
Pubmed	The histone code reader Spin1 controls skeletal muscle development.	MYH1 MYH4	8.94e-05	11	45	2	29168801
Pubmed	Calcineurin is necessary for the maintenance but not embryonic development of slow muscle fibers.	MYH1 MYH4	8.94e-05	11	45	2	16024798
Pubmed	The inhibition of differentiation caused by TGFbeta in fetal myoblasts is dependent upon selective expression of PKCtheta: a possible molecular basis for myoblast diversification during limb histogenesis.	MYH1 MYH8	1.27e-04	13	45	2	8948582
Pubmed	TAF7L modulates brown adipose tissue formation.	MYH1 MYH4	1.27e-04	13	45	2	24876128
Pubmed	Loss of Prox1 in striated muscle causes slow to fast skeletal muscle fiber conversion and dilated cardiomyopathy.	MYH1 MYH4	1.47e-04	14	45	2	24938781
Pubmed	Myopathy associated LDB3 mutation causes Z-disc disassembly and protein aggregation through PKCα and TSC2-mTOR downregulation.	MYH1 MYH4	1.47e-04	14	45	2	33742095
Pubmed	Dry ice is a reliable substrate for the distribution of frozen mouse spermatozoa: A multi-centric study.	MYH4 ALDH3A1	1.70e-04	15	45	2	28532839
Pubmed	Six homeoproteins and a Iinc-RNA at the fast MYH locus lock fast myofiber terminal phenotype.	MYH1 MYH4	1.70e-04	15	45	2	24852826
Pubmed	MusTRD can regulate postnatal fiber-specific expression.	MYH1 MYH4	1.94e-04	16	45	2	16494860
Pubmed	IKKα and alternative NF-κB regulate PGC-1β to promote oxidative muscle metabolism.	MYH1 MYH4	2.20e-04	17	45	2	22351927
Pubmed	Slow and fast fiber isoform gene expression is systematically altered in skeletal muscle of the Sox6 mutant, p100H.	MYH4 MYH8	2.20e-04	17	45	2	16124007
Pubmed	Neuron-specific antioxidant OXR1 extends survival of a mouse model of amyotrophic lateral sclerosis.	MYH1 MYH4	2.47e-04	18	45	2	25753484
Pubmed	Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism.	CCDC50 MYH8 TADA2A ZNF486 CFAP97D1 FAM50A TECR CDC45	2.69e-04	1327	45	8	32694731
Pubmed	FoxP1 orchestration of ASD-relevant signaling pathways in the striatum.	KCNT1 CNR1	3.72e-04	22	45	2	26494785
Pubmed	Opposing gene regulatory programs governing myofiber development and maturation revealed at single nucleus resolution.	MYH4 MYH8	3.72e-04	22	45	2	37468485
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	CCDC50 MYH1 NCBP1 MYH4 MYH8 FAM50A MYH7B TECR	4.70e-04	1442	45	8	35575683
Pubmed	SRSF10 Plays a Role in Myoblast Differentiation and Glucose Production via Regulation of Alternative Splicing.	MYH1 MYH4	5.22e-04	26	45	2	26586428
Pubmed	Synemin acts as a regulator of signalling molecules during skeletal muscle hypertrophy.	MYH4 MYH8	6.06e-04	28	45	2	25179606
Pubmed	Autophagy controls neonatal myogenesis by regulating the GH-IGF1 system through a NFE2L2- and DDIT3-mediated mechanism.	MYH1 MYH4	7.43e-04	31	45	2	30081710
Pubmed	Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.	ATP5MF CCDC82 TECR CCNL1	7.52e-04	317	45	4	11042152
Pubmed	HOXA5 Participates in Brown Adipose Tissue and Epaxial Skeletal Muscle Patterning and in Brown Adipocyte Differentiation.	MYH4 MYH8	7.92e-04	32	45	2	33732701
Pubmed	GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancer.	TADA2A TIPARP	7.92e-04	32	45	2	23535730
Pubmed	Chemical Crosslinking Mass Spectrometry Analysis of Protein Conformations and Supercomplexes in Heart Tissue.	MYH1 MYH8 MYH7B TECR	8.83e-04	331	45	4	29199018
Pubmed	Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning.	ATP5MF TECR	9.48e-04	35	45	2	9653160
Pubmed	Identification of atrogin-1-targeted proteins during the myostatin-induced skeletal muscle wasting.	MYH1 MYH4 MYH8	1.07e-03	155	45	3	22673621
Pubmed	The in vivo Interaction Landscape of Histones H3.1 and H3.3.	NCBP1 ADNP FAM50A TECR CCNL1	1.10e-03	608	45	5	36089195
Interaction	GPIHBP1 interactions	CHID1 MAN2A2 POGLUT2 ADAM22 CDC45	8.12e-06	133	42	5	int:GPIHBP1
Interaction	PRKAG2 interactions	MYH1 MYH4 MYH8 KCNT2	1.20e-05	68	42	4	int:PRKAG2
Interaction	FKBP6 interactions	MYH1 MYH4 MYH8 ALDH3A1	3.06e-05	86	42	4	int:FKBP6
Interaction	RSPH6A interactions	MYH1 MYH4 MYH8	4.81e-05	34	42	3	int:RSPH6A
Interaction	ABTB2 interactions	MYH1 MYH4 MYH8 ADNP	5.75e-05	101	42	4	int:ABTB2
Interaction	ASAH2 interactions	MYH1 MYH4	6.33e-05	6	42	2	int:ASAH2
Interaction	ZSCAN5A interactions	MYH1 MYH4 MYH8	6.75e-05	38	42	3	int:ZSCAN5A
Interaction	TAF6L interactions	MYH4 TADA2A HLA-DPA1 ELAPOR1	9.53e-05	115	42	4	int:TAF6L
Interaction	AURKC interactions	MYH1 MYH4 MYH8	9.80e-05	43	42	3	int:AURKC
Cytoband	3q25.31	TIPARP CCNL1	1.42e-04	18	45	2	3q25.31
Cytoband	17p13.1	MYH1 MYH4 MYH8	2.17e-04	118	45	3	17p13.1
Cytoband	11q21	HEPHL1 CCDC82	8.66e-04	44	45	2	11q21
Cytoband	Ensembl 112 genes in cytogenetic band chr11q21	HEPHL1 CCDC82	1.77e-03	63	45	2	chr11q21
Cytoband	19p12	ZNF486 ZNF100	3.56e-03	90	45	2	19p12
Cytoband	Ensembl 112 genes in cytogenetic band chr17p13	MYH1 MYH4 MYH8	4.76e-03	346	45	3	chr17p13
GeneFamily	Myosin heavy chains	MYH1 MYH4 MYH8 MYH7B	9.52e-09	15	31	4	1098
GeneFamily	Potassium sodium-activated channel subfamily T	KCNT2 KCNT1	2.85e-06	2	31	2	856
Coexpression	HUMMERICH_SKIN_CANCER_PROGRESSION_DN	MYH1 MYH4 ATP5MF MYH8 EFNB1	9.16e-07	103	45	5	M1170
Coexpression	HUMMERICH_SKIN_CANCER_PROGRESSION_DN	MYH1 MYH4 ATP5MF MYH8 EFNB1	1.33e-06	111	45	5	MM1111
Coexpression	HUMMERICH_BENIGN_SKIN_TUMOR_DN	MYH1 MYH4 MYH8	5.28e-06	20	45	3	M1123
Coexpression	HUMMERICH_BENIGN_SKIN_TUMOR_DN	MYH1 MYH4 MYH8	6.15e-06	21	45	3	MM1102
CoexpressionAtlas	skeletal muscle	MYH1 PLCD4 MYH4 MYH8 MYH7B KCNT1	2.79e-05	320	40	6	skeletal muscle
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_2\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	MYH1 MYH4 MYH8 HEPHL1 KCNT2	6.57e-07	164	45	5	382e42701779d12a7948690b3be72d06dd75c8b4
ToppCell	Hippocampus-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)-Slc17a6\|Hippocampus / BrainAtlas - Mouse McCarroll V32	MYH8 ALDH3A1 CFAP97D1 MYH7B	5.19e-06	113	45	4	6f270b7e59c18243e876311df721e948ce21e850
ToppCell	primary_visual_cortex-Neuronal-GABAergic_neuron-Sst-Sst_Chrna2_Ptgdr\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	MYH1 MYH4 MYH8 COL6A6	1.35e-05	144	45	4	71107275767a0728541a3695715c44874b3e5efc
ToppCell	COVID-19-Heart-CM_5_(RYR2-)\|Heart / Disease (COVID-19 only), tissue and cell type	MYH1 PLCD4 KCNT1 TECR	1.81e-05	155	45	4	d7e26696fd9c0a759524f331243db43059b33ed9
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling-Cycling_Proximal_Tubule_Epithelial_Cell_low-phase\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	CATSPERB KCNT2 FASTKD3 COL6A6	2.20e-05	163	45	4	2d6fd2562d78be9f83fa35d811eb7e27eb8cc5d1
ToppCell	Posterior_cortex-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)-Syt6-Excitatory_Neuron.Slc17a7.Syt6-Nefm_(Layer_6a)-\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	MYH1 ALDH3A1 HEPHL1	2.37e-05	55	45	3	b0d37faccc8d04433ee0e76cbce2410530c4c8a1
ToppCell	Posterior_cortex-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)-Syt6-Excitatory_Neuron.Slc17a7.Syt6-Nefm_(Layer_6a)\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	MYH1 ALDH3A1 HEPHL1	2.37e-05	55	45	3	c3ebea1420b68638ed465a8cd8efba860650b795
ToppCell	5'-GW_trimst-1.5-SmallIntestine-Epithelial-neuro-epithelial-K_cells_(GIP+)\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	MYH1 MYH4 MYH8 ELAPOR1	2.84e-05	174	45	4	3503c7dec498597f76a86dbd5e4bb2311e743bde
ToppCell	COVID-19-Heart-Fib_+_EC_+_Pericyte\|COVID-19 / Disease (COVID-19 only), tissue and cell type	MYH4 MYH8 KCNT2 F8	3.39e-05	182	45	4	fbd5e332df73bf7141c822fa67b76367dc962017
ToppCell	Posterior_cortex-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Sst-Inhibitory_Neuron.Gad1Gad2.Sst-Nr2f2_(Neuron.Gad1Gad2.Sst-Nr2f2)\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	MYH4 MYH8 COL6A6	3.39e-05	62	45	3	461d280a1b955033186cfc326f9ace85b4a53c54
ToppCell	Posterior_cortex-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Sst-Inhibitory_Neuron.Gad1Gad2.Sst-Nr2f2_(Neuron.Gad1Gad2.Sst-Nr2f2)-\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	MYH4 MYH8 COL6A6	3.39e-05	62	45	3	9db88da996b9977f5a89afe505cd55e7b5324bc9
ToppCell	Frontal_cortex-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Sst-Inhibitory_Neuron.Gad1Gad2.Sst-Nr2f2_(MGE-derived_cortical_interneurons--Martinotti_cells)\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	MYH1 MYH4 MYH8	3.39e-05	62	45	3	a20620a8869721ea62984c2022ee1b484b455824
ToppCell	Frontal_cortex-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Sst-Inhibitory_Neuron.Gad1Gad2.Sst-Nr2f2_(MGE-derived_cortical_interneurons--Martinotti_cells)-\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	MYH1 MYH4 MYH8	3.39e-05	62	45	3	ee694c06bcd924b4ddf744178ba3a99e04eed51b
ToppCell	Hippocampus-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)-Slc17a6-Excitatory_Neuron.Slc17a6.Grp_(Neuron.Slc17a6.Grp)-\|Hippocampus / BrainAtlas - Mouse McCarroll V32	MYH1 MYH8 CFAP97D1	3.91e-05	65	45	3	b7bc23af54d6d2f7afd584f4df42c24d7c49e344
ToppCell	Hippocampus-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)-Slc17a6-Excitatory_Neuron.Slc17a6.Grp_(Neuron.Slc17a6.Grp)\|Hippocampus / BrainAtlas - Mouse McCarroll V32	MYH1 MYH8 CFAP97D1	3.91e-05	65	45	3	3b3630253f5713c4a688c74c4ea0f98c1fe42594
ToppCell	PBMC-Control-Myeloid-cDC-cDC-cDC_6\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	CCDC50 EFNB1 HLA-DPA1 TIPARP	4.09e-05	191	45	4	6cda82a994f4b205cf54590c979d7c9f3be2b4c8
ToppCell	PBMC-Control-Myeloid-cDC-cDC-cDC_6\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	CCDC50 EFNB1 HLA-DPA1 TIPARP	4.09e-05	191	45	4	4257f02856f3510981e9f84d465d91448d6126e2
ToppCell	PBMC-Control-cDC_6\|Control / Compartment, Disease Groups and Clusters	CCDC50 ATP5MF TIPARP CCNL1	4.18e-05	192	45	4	41a7201febb7d88a39e4ee64df04cce18c691df8
ToppCell	facs-Marrow-KLS-18m-Myeloid-granulocyte_monocyte_progenitor_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CHID1 POGLUT2 FASTKD3 CDC45	4.26e-05	193	45	4	f92bbe70e6c725bfb8c08bfc2a94e375528151a3
ToppCell	facs-Marrow-KLS-18m-Myeloid-granulocyte_monocyte_progenitor_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CHID1 POGLUT2 FASTKD3 CDC45	4.26e-05	193	45	4	44ba79db566d0fa3bbcfe3adf9164bf8c3cb0bc3
ToppCell	droplet-Limb_Muscle-MUSCLE-30m-Mesenchymal\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYH4 COL6A6 TIPARP CCNL1	4.44e-05	195	45	4	5c86fddd6d0530beecf45ea5ba6b823123847696
ToppCell	PBMC-Control-Myeloid-cDC-cDC\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	CCDC50 EFNB1 HLA-DPA1 TIPARP	4.53e-05	196	45	4	553c22c7d48f3b4f6f2b2f10d6e668c5ebb09e8c
ToppCell	PBMC-Control-Myeloid-cDC\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	CCDC50 EFNB1 HLA-DPA1 TIPARP	4.53e-05	196	45	4	e1f763fa9c11bf5f4d80e79f70f9485724ac23fe
ToppCell	PBMC-Control-Myeloid-cDC\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	CCDC50 EFNB1 HLA-DPA1 TIPARP	4.53e-05	196	45	4	d376168e15ec1cf618723259966c76be3698b9b0
ToppCell	Control-Myeloid-cDC\|Control / Disease group, lineage and cell class	CCDC50 EFNB1 HLA-DPA1 TIPARP	4.53e-05	196	45	4	85d92bc226cc28384c30991cc4ebb02ec2e3ec99
ToppCell	PBMC-Control-Myeloid-cDC-cDC\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	CCDC50 EFNB1 HLA-DPA1 TIPARP	4.53e-05	196	45	4	4a9095ba3f6709f88f32bf09184553f4bd211f43
ToppCell	Healthy-cDC\|Healthy / disease group, cell group and cell class	CCDC50 EFNB1 HLA-DPA1 TIPARP	4.71e-05	198	45	4	4cf874333b9fd6cd22ee647cd12c032fc6d05740
ToppCell	frontal_cortex-Neuronal-GABAergic_neuron-Sst-Sst_Myh8_Etv1_\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	MYH1 MYH4 MYH8	1.29e-04	97	45	3	f3c3fb260954f594a9ab8e1ac9a01115767cbc7a
Drug	fast white	MYH1 MYH4 MYH8 MYH7B	1.29e-06	42	44	4	CID000024008
Drug	DMAEMA	FAM50A F8 TECR	2.41e-06	14	44	3	CID000017869
Drug	formycin triphosphate	MYH1 MYH4 MYH8 MYH7B	2.84e-06	51	44	4	CID000122274
Drug	oxovanadium	MYH1 MYH4 MYH8 MYH7B F8	3.45e-06	120	44	5	CID000024411
Drug	2bq7	MYH1 MYH4 MYH8 MYH7B F8	3.89e-06	123	44	5	CID006540267
Drug	purealin	MYH1 MYH4 MYH8 MYH7B	4.77e-06	58	44	4	CID006419303
Drug	clenbuterol	MYH1 MYH4 MYH8 MYH7B TECR	7.85e-06	142	44	5	CID000002783
Drug	AC1N9ZZC	MYH1 MYH4 ATP5MF MYH8 MYH7B	9.92e-06	149	44	5	CID004369374
Drug	SM-2	MYH1 MYH4 MYH8 MYH7B	2.40e-05	87	44	4	CID000486033
Drug	S-(-)-Etomoxir	MYH1 MYH4 MYH8 MYH7B	4.16e-05	100	44	4	CID000060765
Drug	dibenzofuran	ALDH3A1 CNR1 TIPARP	5.42e-05	38	44	3	ctd:C023614
Drug	45-P	MYH7B CDC45	5.45e-05	6	44	2	CID000448407
Drug	blebbistatin	MYH1 MYH4 MYH8 MYH7B	7.42e-05	116	44	4	CID003476986
Drug	B0683	MYH1 MYH4 MYH8 MYH7B	7.67e-05	117	44	4	CID006398969
Drug	AC1LADJ6	MYH1 MYH4 MYH8 MYH7B	1.15e-04	130	44	4	CID000486032
Disease	dilated cardiomyopathy 1S (implicated_via_orthology)	MYH1 MYH4 MYH8 MYH7B	8.97e-10	10	44	4	DOID:0110454 (implicated_via_orthology)
Disease	distal arthrogryposis type 2B3 (implicated_via_orthology)	MYH1 MYH4 MYH8 MYH7B	8.97e-10	10	44	4	DOID:0111602 (implicated_via_orthology)
Disease	inclusion body myositis (implicated_via_orthology)	MYH1 MYH4 MYH8 MYH7B	8.97e-10	10	44	4	DOID:3429 (implicated_via_orthology)
Disease	autosomal dominant hyaline body myopathy (implicated_via_orthology)	MYH1 MYH4 MYH8 MYH7B	8.97e-10	10	44	4	DOID:0111269 (implicated_via_orthology)
Disease	congenital myopathy 6 (implicated_via_orthology)	MYH1 MYH4 MYH8 MYH7B	8.97e-10	10	44	4	DOID:0080719 (implicated_via_orthology)
Disease	distal arthrogryposis type 2A (implicated_via_orthology)	MYH1 MYH4 MYH8 MYH7B	8.97e-10	10	44	4	DOID:0111605 (implicated_via_orthology)
Disease	familial hypertrophic cardiomyopathy (implicated_via_orthology)	MYH1 MYH4 MYH8 MYH7B	8.97e-10	10	44	4	DOID:0080326 (implicated_via_orthology)
Disease	distal arthrogryposis type 1 (implicated_via_orthology)	MYH1 MYH4 MYH8 MYH7B	8.97e-10	10	44	4	DOID:0111596 (implicated_via_orthology)
Disease	distal myopathy (implicated_via_orthology)	MYH1 MYH4 MYH8 MYH7B	2.11e-09	12	44	4	DOID:11720 (implicated_via_orthology)
Disease	myotonia congenita (implicated_via_orthology)	MYH1 MYH4 MYH8 MYH7B	2.11e-09	12	44	4	DOID:2106 (implicated_via_orthology)
Disease	restrictive cardiomyopathy (implicated_via_orthology)	MYH1 MYH4 MYH8 MYH7B	3.04e-09	13	44	4	DOID:397 (implicated_via_orthology)
Disease	distal arthrogryposis (implicated_via_orthology)	MYH1 MYH4 MYH8 MYH7B	5.80e-09	15	44	4	DOID:0050646 (implicated_via_orthology)
Disease	myopathy (implicated_via_orthology)	MYH1 MYH4 MYH8 MYH7B	7.97e-07	48	44	4	DOID:423 (implicated_via_orthology)
Disease	cardiomyopathy (implicated_via_orthology)	MYH1 MYH4 MYH8 MYH7B	3.88e-06	71	44	4	DOID:0050700 (implicated_via_orthology)
Disease	dilated cardiomyopathy (implicated_via_orthology)	MYH1 MYH4 MYH8 MYH7B	6.26e-06	80	44	4	DOID:12930 (implicated_via_orthology)
Disease	anti-neutrophil antibody associated vasculitis	HLA-DPA1 F8	2.75e-03	52	44	2	EFO_0004826

Protein segments in the cluster

Peptide	Gene	Start	Entry
FSSKFFSAYKSHFRN	ADNP	81	Q9H2P0
FHDDIIKKTFHSFYT	CATSPERB	446	Q9H7T0
HFSKSESSHKGFHYK	CCDC50	291	Q8IVM0
GSYHGKKSFETFSHR	ALDH3A1	411	P30838
DFHFHSVYKSRLFEF	ADAM22	181	Q9P0K1
RTDYSFHKFHYLTFV	HLA-DPA1	171	P20036
FHRFFYSKSFVKHSF	CCNL1	111	Q9UK58
DKFSSYHVKTAFFHV	CGAS	431	Q8N884
YSHNFSKKSSKGVHF	TIPARP	571	Q7Z3E1
AKSFSHSFSALAKFH	NCBP1	556	Q09161
HSFSALAKFHEVFKT	NCBP1	561	Q09161
HTFGKFHYKFFRDVS	NLRP11	111	P59045
PSFTSKGLKYFHHFT	ELAPOR1	686	Q6UXG2
YEGKSFTYAAFHAHK	KCNT1	556	Q5JUK3
DHTQYQFGHTKVFFK	MYH7B	801	A7E2Y1
HTQYKFGHTKVFFKA	MYH8	756	P13535
AGFNVEKFYRIKTHH	LACC1	236	Q8IV20
HFSGHVFTVRKKEEY	F8	1976	P00451
DHTQYKFGHTKVFFK	MYH1	756	P12882
KSFTYASFHAHKKFG	KCNT2	506	Q6UVM3
FYIITHLFFKTHSFS	OR12D1	211	P0DN82
KSERSEFLHFFYKHC	PPP4R3C	456	Q6ZMV5
VFYIHKGHSKTFTTS	GSAP	311	A4D1B5
YSFSDHYTHFERVVK	CCDC82	331	Q8N4S0
FSYSFSYKHLKHERL	ATP5MF	76	P56134
FSIHFGFKHKFLASD	CDC45	361	O75419
HHSFYDFIVTKARGK	FAM50A	261	Q14320
FKKHHDYYITSTSNG	EFNB1	126	P98172
TTFRKKLDFGHYVSH	CFAP97D1	21	B2RV13
VYSFIDFHVFHRKDS	CNR1	171	P21554
HYHAESFLFKIDKSY	HEPHL1	1006	Q6MZM0
YAIKKHFAATHSLEF	MAN2A2	316	P49641
SKKFSFYRHHVNFKS	IZUMO4	26	Q1ZYL8
HFFEYKKSRSGRHVV	CHID1	341	Q9BWS9
YSDKLHSEFHLSTFK	COL6A6	71	A6NMZ7
KSVSFRSFTHSKEHY	PLCD4	501	Q9BRC7
FTRGFEYKKHQSDHT	TADA2A	46	O75478
HRHKFSYDTFVDYSI	RNF166	206	Q96A37
FIYFGHHDTFFTKAL	FASTKD3	341	Q14CZ7
DHTQYKFGHTKVFFK	MYH4	756	Q9Y623
AFYRFSYLTKHKTSH	ZNF100	381	Q8IYN0
GFYSAKSFQTHEKTH	ZNF700	516	Q9H0M5
FIYGHKYDFTSSRHT	TECR	111	Q9NZ01
VKHISFFDFFKHKYQ	POGLUT2	351	Q6UW63
FHIFTFVFSHRSKSI	VN1R5	66	Q7Z5H4
FFVKKRHAFSEHSSS	ZBED9	696	Q6R2W3
VFKYFSSFTTHKKIH	ZNF486	246	Q96H40