Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	delta14-sterol reductase activity	LBR TM7SF2	3.17e-05	2	113	2	GO:0050613
Domain	Sterol_reductase_CS	LBR TM7SF2	1.12e-04	3	115	2	IPR018083
Domain	GATA_N	GATA6 GATA5	1.12e-04	3	115	2	IPR008013
Domain	ERG4_ERG24	LBR TM7SF2	1.12e-04	3	115	2	PF01222
Domain	Ergosterol_biosynth_ERG4_ERG24	LBR TM7SF2	1.12e-04	3	115	2	IPR001171
Domain	GATA-N	GATA6 GATA5	1.12e-04	3	115	2	PF05349
Domain	STEROL_REDUCT_2	LBR TM7SF2	1.12e-04	3	115	2	PS01018
Domain	STEROL_REDUCT_1	LBR TM7SF2	1.12e-04	3	115	2	PS01017
Domain	GPR40-rel_orph	FFAR3 GPR42	2.24e-04	4	115	2	IPR013312
Domain	-	ALLC EPHA6 MYCBP2 SSPOP	1.07e-03	73	115	4	2.60.120.260
Domain	MBD	MBD6 MBD4	1.99e-03	11	115	2	SM00391
Domain	MBD	MBD6 MBD4	1.99e-03	11	115	2	PS50982
Domain	Methyl_CpG_DNA-bd	MBD6 MBD4	1.99e-03	11	115	2	IPR001739
Domain	MBD	MBD6 MBD4	1.99e-03	11	115	2	PF01429
Domain	DNA-bd_dom	MBD6 MBD4	1.99e-03	11	115	2	IPR016177
Domain	ZnF_GATA	GATA6 GATA5	2.38e-03	12	115	2	SM00401
Domain	DUF4599	SPATA31A7 SPATA31A5	2.38e-03	12	115	2	PF15371
Domain	DUF4599	SPATA31A7 SPATA31A5	2.38e-03	12	115	2	IPR027970
Domain	Galactose-bd-like	ALLC EPHA6 MYCBP2 SSPOP	2.72e-03	94	115	4	IPR008979
Domain	-	CELSR3 SLIT1 LMAN2 WDFY3	2.82e-03	95	115	4	2.60.120.200
Domain	Znf_GATA	GATA6 GATA5	3.74e-03	15	115	2	IPR000679
Domain	GATA	GATA6 GATA5	3.74e-03	15	115	2	PF00320
Domain	GATA_ZN_FINGER_1	GATA6 GATA5	4.26e-03	16	115	2	PS00344
Domain	VWF_type-D	SSPOP MUC4	4.26e-03	16	115	2	IPR001846
Domain	VWFD	SSPOP MUC4	4.26e-03	16	115	2	PS51233
Domain	GATA_ZN_FINGER_2	GATA6 GATA5	4.26e-03	16	115	2	PS50114
Domain	VWD	SSPOP MUC4	4.26e-03	16	115	2	SM00216
Domain	VWD	SSPOP MUC4	4.26e-03	16	115	2	PF00094
Domain	WD40	GRWD1 MED16 GNB1L WDR54 BOP1 WDFY3	5.37e-03	259	115	6	PF00400
Domain	G_crystallin-rel	CRYBG2 LBR	5.39e-03	18	115	2	IPR011024
Domain	CTCK_1	SSPOP SLIT1	5.39e-03	18	115	2	PS01185
Pubmed	HAPSTR1 localizes HUWE1 to the nucleus to limit stress signaling pathways.	GRWD1 PSMA2 GNB1L LBR MRPS22 EFTUD2 FANCD2 RNH1 MTR BOP1 LMAN2 NUP188	5.49e-07	571	117	12	37167062
Pubmed	Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.	ALLC CRYBG2 EPHA6 POLD1 SLC22A23 RICTOR GRID2 MRPS22 NTM MRPS24 SLIT1 PANK4 CSMD1	3.80e-06	814	117	13	23251661
Pubmed	Tbx1 is required autonomously for cell survival and fate in the pharyngeal core mesoderm to form the muscles of mastication.	GATA6 GATA5 SLIT1 SIX2	4.62e-06	33	117	4	24705356
Pubmed	Large-scale identification of c-MYC-associated proteins using a combined TAP/MudPIT approach.	POLD1 PSMA2 MRPS22 EFTUD2 FANCD2 LONP1 RNH1	7.72e-06	211	117	7	17314511
Pubmed	Expression of the short chain fatty acid receptor GPR41/FFAR3 in autonomic and somatic sensory ganglia.	FFAR3 GPR42	1.12e-05	2	117	2	25637492
Pubmed	Selective tracking of FFAR3-expressing neurons supports receptor coupling to N-type calcium channels in mouse sympathetic neurons.	FFAR3 GPR42	1.12e-05	2	117	2	30478340
Pubmed	Sterol dependent regulation of human TM7SF2 gene expression: role of the encoded 3beta-hydroxysterol Delta14-reductase in human cholesterol biosynthesis.	LBR TM7SF2	1.12e-05	2	117	2	16784888
Pubmed	HEM dysplasia and ichthyosis are likely laminopathies and not due to 3beta-hydroxysterol Delta14-reductase deficiency.	LBR TM7SF2	1.12e-05	2	117	2	17403717
Pubmed	Intestinal FFA3 mediates obesogenic effects in mice on a Western diet.	FFAR3 GPR42	1.12e-05	2	117	2	35858247
Pubmed	Butyrate and propionate protect against diet-induced obesity and regulate gut hormones via free fatty acid receptor 3-independent mechanisms.	FFAR3 GPR42	1.12e-05	2	117	2	22506074
Pubmed	The effects of propionate and valerate on insulin responsiveness for glucose uptake in 3T3-L1 adipocytes and C2C12 myotubes via G protein-coupled receptor 41.	FFAR3 GPR42	1.12e-05	2	117	2	24748202
Pubmed	The Cognitive Improvement and Alleviation of Brain Hypermetabolism Caused by FFAR3 Ablation in Tg2576 Mice Is Persistent under Diet-Induced Obesity.	FFAR3 GPR42	1.12e-05	2	117	2	36362376
Pubmed	Roles of GPR41 and GPR43 in leptin secretory responses of murine adipocytes to short chain fatty acids.	FFAR3 GPR42	1.12e-05	2	117	2	20399779
Pubmed	Male mice that lack the G-protein-coupled receptor GPR41 have low energy expenditure and increased body fat content.	FFAR3 GPR42	1.12e-05	2	117	2	23110765
Pubmed	The Intestinal Microbiota Contributes to the Ability of Helminths to Modulate Allergic Inflammation.	FFAR3 GPR42	1.12e-05	2	117	2	26522986
Pubmed	Microbial short chain fatty acid metabolites lower blood pressure via endothelial G protein-coupled receptor 41.	FFAR3 GPR42	1.12e-05	2	117	2	27664183
Pubmed	Protein arginine methyltransferase 7 regulates cellular response to DNA damage by methylating promoter histones H2A and H4 of the polymerase δ catalytic subunit gene, POLD1.	POLD1 PRMT7	1.12e-05	2	117	2	22761421
Pubmed	G protein coupled receptor 41 regulates fibroblast activation in pulmonary fibrosis via Gαi/o and downstream Smad2/3 and ERK1/2 phosphorylation.	FFAR3 GPR42	1.12e-05	2	117	2	37019194
Pubmed	3-(4-Hydroxy-3-methoxyphenyl) propionic acid contributes to improved hepatic lipid metabolism via GPR41.	FFAR3 GPR42	1.12e-05	2	117	2	38040866
Pubmed	Genetic Inactivation of Free Fatty Acid Receptor 3 Impedes Behavioral Deficits and Pathological Hallmarks in the APPswe Alzheimer's Disease Mouse Model.	FFAR3 GPR42	1.12e-05	2	117	2	35408893
Pubmed	FFAR3 modulates insulin secretion and global gene expression in mouse islets.	FFAR3 GPR42	1.12e-05	2	117	2	26091414
Pubmed	GPR41 modulates insulin secretion and gene expression in pancreatic β-cells and modifies metabolic homeostasis in fed and fasting states.	FFAR3 GPR42	1.12e-05	2	117	2	27550964
Pubmed	Free fatty acid receptor 3 differentially contributes to β-cell compensation under high-fat diet and streptozotocin stress.	FFAR3 GPR42	1.12e-05	2	117	2	32073900
Pubmed	D-serine regulates cerebellar LTD and motor coordination through the δ2 glutamate receptor.	DAO GRID2	1.12e-05	2	117	2	21460832
Pubmed	Disruption of the gene encoding 3beta-hydroxysterol Delta-reductase (Tm7sf2) in mice does not impair cholesterol biosynthesis.	LBR TM7SF2	1.12e-05	2	117	2	18785926
Pubmed	D-amino acid oxidase activity is inhibited by an interaction with bassoon protein at the presynaptic active zone.	DAO BSN	1.12e-05	2	117	2	21700703
Pubmed	Sequence polymorphisms provide a common consensus sequence for GPR41 and GPR42.	FFAR3 GPR42	1.12e-05	2	117	2	19630535
Pubmed	Short-chain fatty acids stimulate leptin production in adipocytes through the G protein-coupled receptor GPR41.	FFAR3 GPR42	1.12e-05	2	117	2	14722361
Pubmed	Human GPR42 is a transcribed multisite variant that exhibits copy number polymorphism and is functional when heterologously expressed.	FFAR3 GPR42	1.12e-05	2	117	2	26260360
Pubmed	Lamin B receptor regulates the growth and maturation of myeloid progenitors via its sterol reductase domain: implications for cholesterol biosynthesis in regulating myelopoiesis.	LBR TM7SF2	1.12e-05	2	117	2	22140257
Pubmed	Twin enzymes, divergent control: The cholesterogenic enzymes DHCR14 and LBR are differentially regulated transcriptionally and post-translationally.	LBR TM7SF2	3.36e-05	3	117	2	31911440
Pubmed	The Orphan G protein-coupled receptors GPR41 and GPR43 are activated by propionate and other short chain carboxylic acids.	FFAR3 GPR42	3.36e-05	3	117	2	12496283
Pubmed	Short-chain fatty acids activate GPR41 and GPR43 on intestinal epithelial cells to promote inflammatory responses in mice.	FFAR3 GPR42	3.36e-05	3	117	2	23665276
Pubmed	Microbial short-chain fatty acids modulate CD8+ T cell responses and improve adoptive immunotherapy for cancer.	FFAR3 GPR42	3.36e-05	3	117	2	34210970
Pubmed	Dietary short-chain fatty acid intake improves the hepatic metabolic condition via FFAR3.	FFAR3 GPR42	3.36e-05	3	117	2	31719611
Pubmed	The amino-terminal domain of glutamate receptor delta2 triggers presynaptic differentiation.	GRID2 BSN	3.36e-05	3	117	2	19000899
Pubmed	Loss of FFA2 and FFA3 increases insulin secretion and improves glucose tolerance in type 2 diabetes.	FFAR3 GPR42	3.36e-05	3	117	2	25581519
Pubmed	Microbiota-Derived Short-Chain Fatty Acids Promote the Memory Potential of Antigen-Activated CD8+ T Cells.	FFAR3 GPR42	3.36e-05	3	117	2	31272808
Pubmed	GPR41 and GPR43 regulate CD8+ T cell priming during herpes simplex virus type 1 infection.	FFAR3 GPR42	3.36e-05	3	117	2	38524121
Pubmed	Short-chain fatty acid receptor GPR41-mediated activation of sympathetic neurons involves synapsin 2b phosphorylation.	FFAR3 GPR42	3.36e-05	3	117	2	22673524
Pubmed	Perception of differentiation cues by GATA factors in primitive endoderm lineage determination of mouse embryonic stem cells.	GATA6 GATA5	3.36e-05	3	117	2	16162334
Pubmed	Acetate and propionate short chain fatty acids stimulate adipogenesis via GPCR43.	FFAR3 GPR42	3.36e-05	3	117	2	16123168
Pubmed	The human lamin B receptor/sterol reductase multigene family.	LBR TM7SF2	3.36e-05	3	117	2	9878250
Pubmed	GPR41 gene expression is mediated by internal ribosome entry site (IRES)-dependent translation of bicistronic mRNA encoding GPR40 and GPR41 proteins.	FFAR3 GPR42	3.36e-05	3	117	2	22493486
Pubmed	Extracellular ionic locks determine variation in constitutive activity and ligand potency between species orthologs of the free fatty acid receptors FFA2 and FFA3.	FFAR3 GPR42	3.36e-05	3	117	2	23066016
Pubmed	Distinct functions are implicated for the GATA-4, -5, and -6 transcription factors in the regulation of intestine epithelial cell differentiation.	GATA6 GATA5	3.36e-05	3	117	2	9566909
Pubmed	Short-chain fatty acids stimulate glucagon-like peptide-1 secretion via the G-protein-coupled receptor FFAR2.	FFAR3 GPR42	3.36e-05	3	117	2	22190648
Pubmed	GPR41/FFAR3 and GPR43/FFAR2 as cosensors for short-chain fatty acids in enteroendocrine cells vs FFAR3 in enteric neurons and FFAR2 in enteric leukocytes.	FFAR3 GPR42	3.36e-05	3	117	2	23885020
Pubmed	Dietary Fiber Confers Protection against Flu by Shaping Ly6c- Patrolling Monocyte Hematopoiesis and CD8+ T Cell Metabolism.	FFAR3 GPR42	3.36e-05	3	117	2	29768180
Pubmed	Effects of the gut microbiota on host adiposity are modulated by the short-chain fatty-acid binding G protein-coupled receptor, Gpr41.	FFAR3 GPR42	3.36e-05	3	117	2	18931303
Pubmed	Induction of a massive endoplasmic reticulum and perinuclear space expansion by expression of lamin B receptor mutants and the related sterol reductases TM7SF2 and DHCR7.	LBR TM7SF2	3.36e-05	3	117	2	19940018
Pubmed	Abnormalities in microbiota/butyrate/FFAR3 signaling in aging gut impair brain function.	FFAR3 GPR42	3.36e-05	3	117	2	38329121
Pubmed	GATA-5: a transcriptional activator expressed in a novel temporally and spatially-restricted pattern during embryonic development.	GATA6 GATA5	3.36e-05	3	117	2	9119112
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	GRWD1 MYCBP2 POLD1 GNB1L RICTOR LBR MRPS22 EFTUD2 NF2 P3H1 ZNF644 MRPS24 PANK4 MTR BOP1 XPR1	3.95e-05	1487	117	16	33957083
Pubmed	CLEC16A interacts with retromer and TRIM27, and its loss impairs endosomal trafficking and neurodevelopment.	MYCBP2 POLD1 PSMA2 RICTOR FANCD2 DHCR24 PANK4 MTR POLR1B LMAN2	4.02e-05	606	117	10	36538041
Pubmed	Global Interactome Mapping of Mitochondrial Intermembrane Space Proteases Identifies a Novel Function for HTRA2.	MED16 RICTOR MRPS22 TEFM PPIF PPOX LONP1 RNH1 MRPS24	6.41e-05	515	117	9	31617661
Pubmed	Olfactory receptor responding to gut microbiota-derived signals plays a role in renin secretion and blood pressure regulation.	FFAR3 GPR42	6.70e-05	4	117	2	23401498
Pubmed	A cluster of four novel human G protein-coupled receptor genes occurring in close proximity to CD22 gene on chromosome 19q13.1.	FFAR3 GPR42	6.70e-05	4	117	2	9344866
Pubmed	FOG-2 and GATA-4 Are coexpressed in the mouse ovary and can modulate mullerian-inhibiting substance expression.	AMH GATA6	6.70e-05	4	117	2	12606418
Pubmed	Wnt2 is a direct downstream target of GATA6 during early cardiogenesis.	GATA6 GATA5	6.70e-05	4	117	2	16621466
Pubmed	Short-chain fatty acids and ketones directly regulate sympathetic nervous system via G protein-coupled receptor 41 (GPR41).	FFAR3 GPR42	6.70e-05	4	117	2	21518883
Pubmed	BMP-mediated induction of GATA4/5/6 blocks somitic responsiveness to SHH.	GATA6 GATA5	6.70e-05	4	117	2	25294942
Pubmed	GATA- and Smad1-dependent enhancers in the Smad7 gene differentially interpret bone morphogenetic protein concentrations.	GATA6 GATA5	6.70e-05	4	117	2	12944489
Pubmed	A family of fatty acid binding receptors.	FFAR3 GPR42	6.70e-05	4	117	2	15684720
Pubmed	Microbial metabolites, short-chain fatty acids, restrain tissue bacterial load, chronic inflammation, and associated cancer in the colon of mice.	FFAR3 GPR42	6.70e-05	4	117	2	29644622
Pubmed	GluRδ2 assembles four neurexins into trans-synaptic triad to trigger synapse formation.	GRID2 BSN	6.70e-05	4	117	2	22457515
Pubmed	Cathepsin B and its interacting proteins, bikunin and TSRC1, correlate with TNF-induced apoptosis of ovarian cancer cells OV-90.	AMBP ADAMTSL4	6.70e-05	4	117	2	16364318
Pubmed	Lung Krüppel-like factor contains an autoinhibitory domain that regulates its transcriptional activation by binding WWP1, an E3 ubiquitin ligase.	GATA6 GATA5	6.70e-05	4	117	2	11375995
Pubmed	Mutations in UVSSA cause UV-sensitive syndrome and destabilize ERCC6 in transcription-coupled DNA repair.	ERCC6 UVSSA	6.70e-05	4	117	2	22466612
Pubmed	Maternal High Fiber Diet during Pregnancy and Lactation Influences Regulatory T Cell Differentiation in Offspring in Mice.	FFAR3 GPR42	6.70e-05	4	117	2	29021375
Pubmed	Majority of cerebrospinal fluid-contacting neurons in the spinal cord of C57Bl/6N mice is present in ectopic position unlike in other studied experimental mice strains and mammalian species.	SPATA31A7 SPATA31A5 OR51G2	7.13e-05	24	117	3	32212159
Pubmed	Genetic susceptibility to distinct bladder cancer subphenotypes.	ERCC6 POLD1 CASR TYR GSTT1 MTR DIO1 MBD4	9.32e-05	421	117	8	19692168
Pubmed	Seven transmembrane G protein-coupled receptor repertoire of gastric ghrelin cells.	FFAR3 GPR42	1.11e-04	5	117	2	24327954
Pubmed	Lactate inhibits lipolysis in fat cells through activation of an orphan G-protein-coupled receptor, GPR81.	FFAR3 GPR42	1.11e-04	5	117	2	19047060
Pubmed	CD1 defines conserved linkage group border between human chromosomes 1 and mouse chromosomes 1 and 3.	TYR CD1D	1.11e-04	5	117	2	2478463
Pubmed	Fatty acid binding receptors and their physiological role in type 2 diabetes.	FFAR3 GPR42	1.11e-04	5	117	2	19009545
Pubmed	The testis-specific VAD1.3/AEP1 interacts with β-actin and syntaxin 1 and directs peri-nuclear/Golgi expression with bipartite nucleus localization (BNL) sequence.	SPATA31A7 SPATA31A5	1.67e-04	6	117	2	20850414
Pubmed	The zinc finger-containing transcription factor Gata-4 is expressed in the developing endocrine pancreas and activates glucagon gene expression.	GATA6 GATA5	1.67e-04	6	117	2	15539431
Pubmed	USP7-mediated deubiquitination differentially regulates CSB but not UVSSA upon UV radiation-induced DNA damage.	ERCC6 UVSSA	1.67e-04	6	117	2	31775559
Pubmed	Targeted disruption of the spermatid-specific gene Spata31 causes male infertility.	SPATA31A7 SPATA31A5	1.67e-04	6	117	2	25930072
Pubmed	Free fatty acid receptors act as nutrient sensors to regulate energy homeostasis.	FFAR3 GPR42	1.67e-04	6	117	2	19460454
Pubmed	Genetic polymorphisms influencing arsenic metabolism: evidence from Argentina.	GSTT1 MTR	1.67e-04	6	117	2	17450230
Pubmed	Gata4 expression in lateral mesoderm is downstream of BMP4 and is activated directly by Forkhead and GATA transcription factors through a distal enhancer element.	GATA6 GATA5	2.33e-04	7	117	2	15987774
Pubmed	Polymorphisms in genes involved in DNA repair and metabolism of xenobiotics in individual susceptibility to sporadic diffuse gastric cancer.	GSTT1 MTR	2.33e-04	7	117	2	17617021
Pubmed	Mammalian Gcm genes induce Hes5 expression by active DNA demethylation and induce neural stem cells.	HES3 MBD4	2.33e-04	7	117	2	21765423
Pubmed	Structural basis of human transcription-DNA repair coupling.	ERCC6 UVSSA	2.33e-04	7	117	2	34526721
Pubmed	Tbx1 haploinsufficiency is linked to behavioral disorders in mice and humans: implications for 22q11 deletion syndrome.	GNB1L TYR	2.33e-04	7	117	2	16684884
Pubmed	GATA factors and androgen receptor collaborate to transcriptionally activate the Rhox5 homeobox gene in Sertoli cells.	GATA6 GATA5	2.33e-04	7	117	2	18212046
Pubmed	A compendium of expression patterns of cholesterol biosynthetic enzymes in the mouse embryo.	LBR DHCR24 TM7SF2	2.65e-04	37	117	3	26108225
Pubmed	PTEN identified as important risk factor of chronic obstructive pulmonary disease.	ERCC6 POLD1 CASR TYR MTR DIO1 MBD4	2.83e-04	374	117	7	19625176
Pubmed	Gata6 restricts Isl1 to the posterior of nascent hindlimb buds through Isl1 cis-regulatory modules.	GATA6 GATA5	3.10e-04	8	117	2	29197504
Pubmed	Vagal neuron expression of the microbiota-derived metabolite receptor, free fatty acid receptor (FFAR3), is necessary for normal feeding behavior.	FFAR3 GPR42	3.10e-04	8	117	2	34626852
Pubmed	Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton.	GNB1L RICTOR	3.10e-04	8	117	2	15268862
Pubmed	Variable drug metabolism genes in Arab population.	GSTT1 MTR	3.10e-04	8	117	2	15111988
Pubmed	The cardiac determination factor, Nkx2-5, is activated by mutual cofactors GATA-4 and Smad1/4 via a novel upstream enhancer.	GATA6 GATA5	3.10e-04	8	117	2	14662776
Pubmed	Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway.	ERCC6 POLD1 CASR TYR MTR DIO1 MBD4	3.17e-04	381	117	7	18676680
Pubmed	Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China.	ERCC6 POLD1 CASR TYR MTR DIO1 MBD4	3.22e-04	382	117	7	19170196
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	ERCC6 POLD1 DVL2 RICTOR LBR FANCD2 RNH1 PANK4 MTR NUP188 WDFY3 CSMD1	3.91e-04	1116	117	12	31753913
Pubmed	Identification of high-molecular-weight proteins with multiple EGF-like motifs by motif-trap screening.	CELSR3 SLIT1	3.98e-04	9	117	2	9693030
Pubmed	Regulation of BMP-dependent chondrogenesis in early limb mesenchyme by TGFbeta signals.	GATA6 GATA5	3.98e-04	9	117	2	20501701
Cytoband	3q27	ABCC5 CHRD MAP3K13	3.56e-05	25	117	3	3q27
Cytoband	Ensembl 112 genes in cytogenetic band chr9q12	SPATA31A7 SPATA31A5	1.79e-04	8	117	2	chr9q12
Cytoband	Ensembl 112 genes in cytogenetic band chr3q27	ABCC5 TBCCD1 CHRD MAP3K13	3.35e-04	128	117	4	chr3q27
GeneFamily	WD repeat domain containing	GRWD1 MED16 GNB1L WDR54 BOP1 WDFY3	7.63e-04	262	75	6	362
GeneFamily	Zinc fingers CXXC-type\|Methyl-CpG binding domain containing	MBD6 MBD4	9.12e-04	11	75	2	1025
GeneFamily	GATA zinc finger domain containing\|Myb/SANT domain containing	GATA6 GATA5	1.72e-03	15	75	2	82
Disease	UV-sensitive syndrome (is_implicated_in)	ERCC6 UVSSA	4.05e-05	3	109	2	DOID:0060240 (is_implicated_in)
Disease	UV-Sensitive Syndrome	ERCC6 UVSSA	4.05e-05	3	109	2	C1833561
Disease	colorectal carcinoma (is_implicated_in)	ERCC6 GSTT1 MBD4	7.17e-05	22	109	3	DOID:0080199 (is_implicated_in)
Disease	lung cancer (is_implicated_in)	ERCC6 RICTOR GSTT1 MBD4	1.66e-04	74	109	4	DOID:1324 (is_implicated_in)
Disease	zinc finger protein 276 measurement	MED16 C7	2.01e-04	6	109	2	EFO_0802227
Disease	Treacher Collins syndrome (implicated_via_orthology)	EFTUD2 POLR1B	2.01e-04	6	109	2	DOID:2908 (implicated_via_orthology)
Disease	regulator of G-protein signaling 8 measurement	MED16 C7	2.81e-04	7	109	2	EFO_0801997
Disease	tumor necrosis factor ligand superfamily member 6, soluble form measurement	CELSR3 BSN	2.81e-04	7	109	2	EFO_0020797
Disease	uroplakin-3b-like protein measurement	MED16 C7	2.81e-04	7	109	2	EFO_0802204
Disease	tumor necrosis factor receptor superfamily member 3 measurement	MED16 C7	3.73e-04	8	109	2	EFO_0020813
Disease	desmoglein-1 measurement	MED16 C7	3.73e-04	8	109	2	EFO_0020321
Disease	alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 measurement	MED16 C7	3.73e-04	8	109	2	EFO_0801373
Disease	opioid-binding protein/cell adhesion molecule measurement	NTM C7	3.73e-04	8	109	2	EFO_0020618
Disease	chromobox protein homolog 5 measurement	MED16 C7	3.73e-04	8	109	2	EFO_0020258
Disease	kallikrein-6 measurement	MED16 C7	3.73e-04	8	109	2	EFO_0801739
Disease	epididymal-specific lipocalin-10 measurement	MED16 C7	4.79e-04	9	109	2	EFO_0801576
Disease	ectonucleoside triphosphate diphosphohydrolase 1 measurement	MED16 C7	4.79e-04	9	109	2	EFO_0020342
Disease	cyclin-dependent kinase 5:cyclin-dependent kinase 5 activator 1 complex measurement	MED16 C7	4.79e-04	9	109	2	EFO_0020296
Disease	cellular retinoic acid-binding protein 1 measurement	MED16 C7	4.79e-04	9	109	2	EFO_0801463
Disease	mast cell-expressed membrane protein 1 measurement	MED16 C7	4.79e-04	9	109	2	EFO_0801787
Disease	interleukin-34 measurement	MED16 C7	4.79e-04	9	109	2	EFO_0020505
Disease	heterogeneous nuclear ribonucleoprotein q measurement	MED16 C7	4.79e-04	9	109	2	EFO_0020443
Disease	DNA repair protein rad51 homolog 1 measurement	MED16 C7	5.97e-04	10	109	2	EFO_0020330
Disease	tropomyosin beta chain measurement	MED16 C7	5.97e-04	10	109	2	EFO_0020787
Disease	interleukin-37 measurement	MED16 C7	5.97e-04	10	109	2	EFO_0020506
Disease	insulin growth factor-like family member 3 measurement	MED16 C7	5.97e-04	10	109	2	EFO_0801700
Disease	Fanconi anemia (is_implicated_in)	FANCD2 GSTT1	5.97e-04	10	109	2	DOID:13636 (is_implicated_in)
Disease	esophagus squamous cell carcinoma (is_implicated_in)	RICTOR GSTT1 MBD4	6.21e-04	45	109	3	DOID:3748 (is_implicated_in)
Disease	PR domain zinc finger protein 1 measurement	MED16 BSN	7.28e-04	11	109	2	EFO_0801904
Disease	interleukin-10 receptor subunit alpha measurement	MED16 C7	7.28e-04	11	109	2	EFO_0021890
Disease	glycerol-3-phosphate dehydrogenase 1-like protein measurement	MED16 C7	7.28e-04	11	109	2	EFO_0801640
Disease	oncostatin-M measurement	MED16 C7	8.71e-04	12	109	2	EFO_0010792
Disease	tyrosine-protein kinase ZAP-70 measurement	MED16 C7	8.71e-04	12	109	2	EFO_0020833
Disease	intelligence, self reported educational attainment	SLC22A23 CELSR3 CACNA1I BSN	9.48e-04	117	109	4	EFO_0004337, EFO_0004784
Disease	tetralogy of Fallot (is_implicated_in)	GATA6 GATA5	1.03e-03	13	109	2	DOID:6419 (is_implicated_in)
Disease	kallikrein-12 measurement	MED16 C7	1.03e-03	13	109	2	EFO_0008194
Disease	Colorectal Carcinoma	CCDC9B ERCC6 POLD1 PSMA2 ABCC5 GRID2 GATA5 PPOX PANK4	1.20e-03	702	109	9	C0009402
Disease	skin melanoma (is_implicated_in)	TYR GSTT1	1.20e-03	14	109	2	DOID:8923 (is_implicated_in)
Disease	ventricular septal defect (is_implicated_in)	GATA6 GATA5	1.20e-03	14	109	2	DOID:1657 (is_implicated_in)
Disease	Hallux valgus	UNC5CL SLIT1 MTR	1.44e-03	60	109	3	HP_0001822
Disease	response to triptolide, cytotoxicity measurement	ADGRA2 CSMD1	1.57e-03	16	109	2	EFO_0006952, EFO_0007662
Disease	Tetralogy of Fallot	GATA6 GATA5	1.57e-03	16	109	2	C0039685
Disease	SLAM family member 7 measurement	C7 LY9	1.77e-03	17	109	2	EFO_0008287
Disease	response to methotrexate, juvenile idiopathic arthritis	CACNA1I CSMD1	2.22e-03	19	109	2	EFO_0002609, GO_0031427
Disease	Conventional (Clear Cell) Renal Cell Carcinoma	GSTT1 NF2 MUC4 WNK3	2.25e-03	148	109	4	C0279702
Disease	glucose measurement	CCDC9B MYCBP2 AQP7 BOP1 CACNA1I BSN	2.92e-03	380	109	6	EFO_0004468
Disease	ATRIAL FIBRILLATION, FAMILIAL, 1 (disorder)	GATA6 GATA5	2.98e-03	22	109	2	C1843687
Disease	Carcinoma of lung	ERCC6 RICTOR	3.25e-03	23	109	2	C0684249
Disease	congenital heart disease (is_implicated_in)	GATA6 GSTT1	3.54e-03	24	109	2	DOID:1682 (is_implicated_in)

Protein segments in the cluster

Peptide	Gene	Start	Entry
TRRVSVWPVAFVGGL	B3GAT1	211	Q9P2W7
VRCLSVSPGGQWLVS	BOP1	416	Q14137
IVRGPCRAFIQLWAF	AMBP	291	P02760
GKGVWRPIFLCISRE	ADAMTSL4	681	Q6UY14
GTWNIGDERPSCRVI	CSMD1	2606	Q96PZ7
WCVLRLGIQGVIRGF	ALLC	61	Q8N6M5
NGILLVPGCEWAVFR	ALLC	251	Q8N6M5
GALAVSQRWLPRVVC	ADGRA2	1036	Q96PE1
LFFIGEPQDWTCRLR	CASR	666	P41180
CWEGRGQTLLRPFIT	ABHD3	86	Q8WU67
ARLPCFNGRVVSWLV	DVL2	76	O14641
RQRCLGAVSGVPTWT	ERCC6	1301	Q03468
RNTEWCFGLVIFAGP	ATP8B2	256	P98198
RGQRCAIALWFTLDP	P3H1	666	Q32P28
FCELRPGLIGWVVIN	LBR	386	Q14739
QPIFCVLRGDGRLEW	NIBAN3	116	Q86XR2
CTGVWAGALQRDPLL	DAO	181	P14920
PVSIGRWGLGSRQLC	MUC4	4596	Q99102
VPIGWQRCVREGAVL	MBD6	21	Q96DN6
CRSSILAGGQPRWTL	GNB1L	116	Q9BYB4
WKNCIDITGVRLPTG	LMAN2	236	Q12907
DWSPRVTGRLLTGDC	GRWD1	221	Q9BQ67
NGTSRRAGCVWLLPL	NTM	321	Q9P121
CQEGRLRPGWLITLS	GPR179	236	Q6PRD1
GWGALPAENISLCRI	BSN	1631	Q9UPA5
VSRNWARGTCGPRVT	CCDC9B	126	Q6ZUT6
CQLFTTELGRDGIRW	FAM86B1	256	Q8N7N1
RGVRKLGCWNPVTGL	GRID2	411	O43424
RQTVLRVVGPCWTCG	PLSCR3	201	Q9NRY6
PLQTLWLCRIGRTGG	LENG9	476	Q96B70
CTLPTVLGIFWVGAR	OR51G2	81	Q8NGK0
GRCGLVRWLQVLLPF	PCDHGB2	6	Q9Y5G2
GWLPQEGSVRRILCA	FAM205C	86	A6NFA0
SSRCAESPGLGLRVW	HES3	161	Q5TGS1
LRSLWPRVETGGCTA	PPM1N	151	Q8N819
GAWLLRGQRTCDASP	LONP1	36	P36776
RWGPRDLATFGVCNT	AMH	91	P03971
AVTFANCALGRVPWR	AQP7	96	O14520
GGPLVCEFNRSWLQI	PRSS38	246	A1L453
RPRLGQAGLVSVACW	GPR42	126	O15529
TFRSWAGIINLCKPG	RICTOR	291	Q6R327
CRTLGLRETWFFGLQ	NF2	51	P35240
QRWIKNCLAVEGRGP	MED16	821	Q9Y2X0
RCFPGVVRSLDALGW	PANK4	536	Q9NVE7
FCELRPGLIGWVLIN	TM7SF2	191	O76062
LEGLFGCLRPVWNII	MAP3K13	131	O43283
PVVRLSGQRCNIWEF	DIO1	96	P49895
GPDAASLRRVVWIFC	ABCC5	161	O15440
LWEENVCGTPGRTRV	RGL4	26	Q8IZJ4
SWPGRGLVTRFLQIS	FAM189B	581	P81408
NCGALSTPLWRRDGT	GATA5	191	Q9BWX5
VNCGSIQTPLWRRDG	GATA6	391	Q92908
GRNIACWFPRTFILS	IL5RA	191	Q01344
RWGVRCDLANGVIPR	HYLS1	276	Q96M11
GESWPVLVGRRFLSL	KDM3A	6	Q9Y4C1
GQALSWFCGSERRPV	BSPRY	26	Q5W0U4
VVEFRDLWRIRSPCG	PRMT7	521	Q9NVM4
WGSAEVPQRLFPLRC	CD1D	16	P15813
CTGRPGWLTVSLRVG	DHCR24	91	Q15392
IGVQLWAGLLRNRCF	CACNA1I	226	Q9P0X4
IGNPVARCGEDLRWL	C7	606	P10643
SGWAPVASIRVVRGC	CRYBG2	1011	Q8N1P7
RPRLGQAGLVSVACW	FFAR3	126	O14843
CDGLTIWEERGRPIA	CCS	246	O14618
VPCGWERVVKQRLFG	MBD4	86	O95243
CSGPERNTKLWIGLF	LY9	446	Q9HBG7
LRPGTLCTVAGWGRV	CTSG	136	P08311
FVGSPCGLNLRNVLW	ERMARD	176	Q5T6L9
GPVVSFWFGRRLVVS	CYP20A1	66	Q6UW02
APCALQTWGSERRLG	CELSR3	2961	Q9NYQ7
RDPVIQICSLGLRWG	POLD1	331	P28340
ASLARQFLCRVWPSG	FANCD2	1156	Q9BXW9
PVLSWQRLGCGGVLT	PARP10	41	Q53GL7
FTLRDCNSIPWVLGT	EPHA6	106	Q9UF33
GCQVFEGRPKLATWR	GSTT1	181	P30711
WSLLRSSPGVERVCF	MRPS22	11	P82650
CSGLLGPRVLSWSRE	MRPS24	6	Q96EL2
LPAVCSWIQRFTRVG	UVSSA	341	Q2YD98
WARARCGALLQPLFT	SSPOP	1201	A2VEC9
IGNITFGWLTDRRCL	SLC16A12	331	Q6ZSM3
ITGCIADWVGRRPVL	SLC22A23	246	A1A5C7
FWRGVSLRPIGASCR	LEAP2	41	Q969E1
TNEGLIPVCVRRSWL	SPATA31A7	741	Q8IWB4
LRARGVVGFWPAQSI	MTR	1026	Q99707
TAWRKICPLFQGIGL	SLC6A12	106	P48065
QRLSGINRWCISGTP	SHPRH	836	Q149N8
INRWCISGTPVQRGL	SHPRH	841	Q149N8
NRWLGPRITFGFISC	MYCBP2	4461	O75592
GLDALLTQGVCPRRW	PRAMEF27	86	A3QJZ7
LFTAGERWRCFLTPS	TEFM	6	Q96QE5
CGSRWLGLLSVPRSV	PPIF	6	P30405
GLKPQGARWVCRSFR	PLA2G3	351	Q9NZ20
YNGTVGLWRRCITIP	CLDND1	71	Q9NY35
PGRVRALVDTFCWIA	LINC01559	71	Q495D7
DGLVCGVWRAVPRLS	CHRD	231	Q9H2X0
WGRRRPFILALCVGV	SLC45A4	116	Q5BKX6
GVRAIVQCIPAWLRF	XPR1	446	Q9UBH6
PVCGLSLQAEGRWKV	PPOX	256	P50336
RWFQARASGLQPCVI	ZFR2	776	Q9UPR6
REFLRLASPLNCGAW	WDFY3	941	Q8IZQ1
TNEGLIPVCVRRSWL	SPATA31A5	741	Q5VU36
VPWGLCELARLIGFT	TMEM94	626	Q12767
GFWGPNCTERRLLVR	TYR	106	P14679
PRRLLGACWTLNGQE	UNC5CL	36	Q8IV45
GGPCVRSSRELWTIL	NUP188	6	Q5SRE5
GVRPFGVSLLICGWN	PSMA2	126	P25787
GQPGSVLRVLWLADC	RNH1	366	P13489
NIERLGRFLWSLPAC	SIX2	26	Q9NPC8
CGLVFRGPLSVQEDW	ZNF644	1266	Q9H582
LVCFPLSVVWRQGKG	TLCD3B	141	Q71RH2
LTRGQWPVLESRCET	ZNF566	71	Q969W8
WEQSRVGQLCRGPQL	STRCP1	1421	A6NGW2
VVAPRCELTVWSRQG	SYCN	81	Q0VAF6
LETWLRSCLTGNPFG	TBCCD1	256	Q9NVR7
QWGTREGPLCDELIR	EFTUD2	771	Q15029
VRRLLPESWGFLCPV	POLR1B	486	Q9H9Y6
ICQTTRPLSWVECRG	SLIT1	1476	O75093
GLLCVWRSGPEFTLL	WDR54	191	Q9H977
TLRCWTPARGVSFVL	TARM1	46	B6A8C7
GLVFILRPEQSTCTW	TM7SF3	96	Q9NS93
SPVGRWRFCINQTIR	WNK3	866	Q9BYP7