Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionpotassium:chloride symporter activity

SLC12A6 SLC12A4 SLC12A7 SLC12A5

1.62e-089694GO:0015379
GeneOntologyMolecularFunctionammonium channel activity

SLC12A6 SLC12A4 SLC12A7 SLC12A5

6.33e-0812694GO:0008519
GeneOntologyMolecularFunctionactivin receptor activity, type I

ACVR1 ACVR1B ACVRL1

3.93e-075693GO:0016361
GeneOntologyMolecularFunctionchloride:monoatomic cation symporter activity

SLC12A6 SLC12A4 SLC12A7 SLC12A5

1.10e-0623694GO:0015377
GeneOntologyMolecularFunctionmonoatomic anion:monoatomic cation symporter activity

SLC12A6 SLC12A4 SLC12A7 SLC12A5

1.84e-0626694GO:0015296
GeneOntologyMolecularFunctionactivin receptor activity

ACVR1 ACVR1B ACVRL1

3.27e-069693GO:0017002
GeneOntologyMolecularFunctionactivin binding

ACVR1 ACVR1B ACVRL1

8.50e-0612693GO:0048185
GeneOntologyMolecularFunctionpotassium ion transmembrane transporter activity

SLC12A6 SLC12A4 CPOX SLC12A7 KCNAB3 SLC12A5

2.43e-05167696GO:0015079
GeneOntologyMolecularFunctiontransmembrane receptor protein serine/threonine kinase activity

ACVR1 ACVR1B ACVRL1

4.32e-0520693GO:0004675
GeneOntologyMolecularFunctionchloride transmembrane transporter activity

SLC12A6 SLC12A4 UCP2 SLC12A7 SLC12A5

7.24e-05125695GO:0015108
GeneOntologyMolecularFunctiontransforming growth factor beta receptor activity, type I

ACVR1 ACVRL1

1.17e-045692GO:0005025
GeneOntologyMolecularFunctionmonoatomic anion transmembrane transporter activity

SLC12A6 SLC12A4 UCP2 SLC12A7 SLC12A5

1.76e-04151695GO:0008509
GeneOntologyMolecularFunctionprotein kinase activity

HIPK4 TIE1 SCYL1 ELP1 TNK2 ACVR1 ACVR1B ACVRL1 GRK1

2.14e-04600699GO:0004672
GeneOntologyMolecularFunctiontransmembrane receptor protein kinase activity

TIE1 ACVR1 ACVR1B ACVRL1

2.14e-0485694GO:0019199
GeneOntologyMolecularFunctioninorganic anion transmembrane transporter activity

SLC12A6 SLC12A4 UCP2 SLC12A7 SLC12A5

3.14e-04171695GO:0015103
GeneOntologyMolecularFunctioninterleukin-17 receptor activity

IL17RE IL17RC

3.25e-048692GO:0030368
GeneOntologyMolecularFunctionBMP receptor activity

ACVR1 ACVRL1

3.25e-048692GO:0098821
GeneOntologyMolecularFunctionmonoatomic cation transmembrane transporter activity

SLC12A6 SLC12A4 SCN1B UCP2 CPOX SLC12A7 KCNAB3 UNC80 SLC12A5

4.49e-04664699GO:0008324
GeneOntologyMolecularFunctionphosphotransferase activity, alcohol group as acceptor

HIPK4 TIE1 SCYL1 ELP1 TNK2 ACVR1 ACVR1B ACVRL1 GRK1

7.20e-04709699GO:0016773
GeneOntologyMolecularFunctiontranslation initiation factor activity

EIF3A EIF3C EIF3CL

7.30e-0451693GO:0003743
GeneOntologyMolecularFunctionsolute:monoatomic cation symporter activity

SLC12A6 SLC12A4 SLC12A7 SLC12A5

7.69e-04119694GO:0015294
GeneOntologyMolecularFunctiontransforming growth factor beta receptor activity

ACVR1 ACVRL1

8.96e-0413692GO:0005024
GeneOntologyMolecularFunctionmetal ion transmembrane transporter activity

SLC12A6 SLC12A4 SCN1B CPOX SLC12A7 KCNAB3 SLC12A5

1.10e-03465697GO:0046873
GeneOntologyMolecularFunctionkinase activity

HIPK4 TIE1 SCYL1 ELP1 TNK2 ACVR1 ACVR1B ACVRL1 GRK1

1.22e-03764699GO:0016301
GeneOntologyMolecularFunctioninorganic cation transmembrane transporter activity

SLC12A6 SLC12A4 SCN1B UCP2 CPOX SLC12A7 KCNAB3 SLC12A5

1.40e-03627698GO:0022890
GeneOntologyMolecularFunctionmonoatomic ion transmembrane transporter activity

SLC12A6 SLC12A4 SCN1B UCP2 CPOX SLC12A7 KCNAB3 UNC80 SLC12A5

1.58e-03793699GO:0015075
GeneOntologyMolecularFunctionprotein tyrosine kinase activity

HIPK4 TIE1 SCYL1 TNK2

1.60e-03145694GO:0004713
GeneOntologyMolecularFunctionprotein tyrosine kinase binding

ANGPT2 SHC1 EIF3A ACVR1

1.77e-03149694GO:1990782
GeneOntologyMolecularFunctionsymporter activity

SLC12A6 SLC12A4 SLC12A7 SLC12A5

1.81e-03150694GO:0015293
GeneOntologyMolecularFunctiongrowth factor binding

SHC1 ACVR1 ACVR1B ACVRL1

2.09e-03156694GO:0019838
GeneOntologyMolecularFunctionchannel activity

SLC12A6 SLC12A4 SCN1B SLC12A7 KCNAB3 UNC80 SLC12A5

2.20e-03525697GO:0015267
GeneOntologyMolecularFunctionpassive transmembrane transporter activity

SLC12A6 SLC12A4 SCN1B SLC12A7 KCNAB3 UNC80 SLC12A5

2.23e-03526697GO:0022803
GeneOntologyMolecularFunctionprotein kinase binding

SLC12A6 ANGPT2 SLC12A4 SHC1 EIF3A ACVR1 ACVRL1 SLC12A7 SLC12A5

3.02e-03873699GO:0019901
GeneOntologyMolecularFunctiontranslation factor activity, RNA binding

EIF3A EIF3C EIF3CL

3.19e-0385693GO:0008135
GeneOntologyMolecularFunctionSMAD binding

ACVR1 ACVR1B ACVRL1

3.29e-0386693GO:0046332
GeneOntologyMolecularFunctionsecondary active transmembrane transporter activity

SLC12A6 SLC12A4 UCP2 SLC12A7 SLC12A5

3.59e-03296695GO:0015291
GeneOntologyMolecularFunctiontransforming growth factor beta binding

ACVR1 ACVRL1

3.63e-0326692GO:0050431
GeneOntologyMolecularFunctionreceptor tyrosine kinase binding

ANGPT2 SHC1 EIF3A

3.74e-0390693GO:0030971
GeneOntologyMolecularFunctionactive monoatomic ion transmembrane transporter activity

SLC12A6 SLC12A4 CPOX SLC12A7 SLC12A5

3.85e-03301695GO:0022853
GeneOntologyMolecularFunctionprotein serine/threonine kinase activity

HIPK4 TNK2 ACVR1 ACVR1B ACVRL1 GRK1

4.39e-03446696GO:0004674
GeneOntologyMolecularFunctioninorganic molecular entity transmembrane transporter activity

SLC12A6 SLC12A4 SCN1B UCP2 CPOX SLC12A7 KCNAB3 SLC12A5

4.50e-03758698GO:0015318
GeneOntologyMolecularFunctioncell adhesion molecule binding

TENM4 TENM3 SCYL1 TNKS1BP1 FNBP1L ACVR1 TENM2

4.56e-03599697GO:0050839
GeneOntologyMolecularFunctiontransferase activity, transferring phosphorus-containing groups

HIPK4 TIE1 SCYL1 ELP1 TNK2 ACVR1 ACVR1B ACVRL1 GRK1

4.84e-03938699GO:0016772
GeneOntologyMolecularFunctionkinase binding

SLC12A6 ANGPT2 SLC12A4 SHC1 EIF3A ACVR1 ACVRL1 SLC12A7 SLC12A5

5.96e-03969699GO:0019900
GeneOntologyMolecularFunctionactive transmembrane transporter activity

SLC12A6 SLC12A4 UCP2 CPOX SLC12A7 SLC12A5

6.07e-03477696GO:0022804
GeneOntologyMolecularFunctiontranslation regulator activity, nucleic acid binding

EIF3A EIF3C EIF3CL

6.88e-03112693GO:0090079
GeneOntologyMolecularFunctiontranslation initiation factor binding

EIF3C EIF3CL

8.03e-0339692GO:0031369
GeneOntologyBiologicalProcessammonium transmembrane transport

SLC12A6 SLC12A4 SLC12A7 SLC12A5

7.55e-0813684GO:0072488
GeneOntologyBiologicalProcessammonium import across plasma membrane

SLC12A6 SLC12A4 SLC12A7

1.37e-074683GO:0140157
GeneOntologyBiologicalProcesschloride ion homeostasis

SLC12A6 SLC12A4 SLC12A7 SLC12A5

1.30e-0625684GO:0055064
GeneOntologyBiologicalProcessmonoatomic anion homeostasis

SLC12A6 SLC12A4 SLC12A7 SLC12A5

2.08e-0628684GO:0055081
GeneOntologyBiologicalProcesspotassium ion homeostasis

SLC12A6 SLC12A4 SLC12A7 SLC12A5

6.57e-0637684GO:0055075
GeneOntologyBiologicalProcesscell volume homeostasis

SLC12A6 SLC12A4 SLC12A7 SLC12A5

1.10e-0542684GO:0006884
GeneOntologyBiologicalProcessformation of cytoplasmic translation initiation complex

EIF3A EIF3C EIF3CL

1.52e-0515683GO:0001732
GeneOntologyBiologicalProcesspotassium ion import across plasma membrane

SLC12A6 SLC12A4 SLC12A7 SLC12A5

2.40e-0551684GO:1990573
GeneOntologyBiologicalProcesschloride transmembrane transport

SLC12A6 SLC12A4 UCP2 SLC12A7 SLC12A5

3.43e-05112685GO:1902476
GeneOntologyBiologicalProcesschloride transport

SLC12A6 SLC12A4 UCP2 SLC12A7 SLC12A5

6.49e-05128685GO:0006821
GeneOntologyBiologicalProcessinorganic anion transmembrane transport

SLC12A6 SLC12A4 UCP2 SLC12A7 SLC12A5

8.06e-05134685GO:0098661
GeneOntologyBiologicalProcessmonoatomic anion transmembrane transport

SLC12A6 SLC12A4 UCP2 SLC12A7 SLC12A5

1.50e-04153685GO:0098656
GeneOntologyBiologicalProcessendothelial cell differentiation

PLOD3 TIE1 ACVR1 CUL7 ACVRL1

1.75e-04158685GO:0045446
GeneOntologyBiologicalProcesspotassium ion transport

SLC12A6 SLC12A4 CPOX SLC12A7 KCNAB3 SLC12A5

2.75e-04272686GO:0006813
GeneOntologyBiologicalProcesslymphatic endothelial cell differentiation

TIE1 ACVRL1

2.96e-048682GO:0060836
GeneOntologyBiologicalProcessinorganic anion transport

SLC12A6 SLC12A4 UCP2 SLC12A7 SLC12A5

3.20e-04180685GO:0015698
GeneOntologyBiologicalProcessendothelium development

PLOD3 TIE1 ACVR1 CUL7 ACVRL1

3.37e-04182685GO:0003158
GeneOntologyBiologicalProcessmonoatomic anion transport

SLC12A6 SLC12A4 UCP2 SLC12A7 SLC12A5

3.45e-04183685GO:0006820
GeneOntologyBiologicalProcesscytoplasmic translational initiation

EIF3A EIF3C EIF3CL

4.40e-0445683GO:0002183
GeneOntologyCellularComponenteukaryotic translation initiation factor 3 complex, eIF3m

EIF3A EIF3C EIF3CL

2.85e-069693GO:0071541
GeneOntologyCellularComponenteukaryotic translation initiation factor 3 complex

EIF3A EIF3C EIF3CL

1.87e-0516693GO:0005852
GeneOntologyCellularComponenteukaryotic 48S preinitiation complex

EIF3A EIF3C EIF3CL

2.71e-0518693GO:0033290
GeneOntologyCellularComponenteukaryotic 43S preinitiation complex

EIF3A EIF3C EIF3CL

3.21e-0519693GO:0016282
GeneOntologyCellularComponenttranslation preinitiation complex

EIF3A EIF3C EIF3CL

3.77e-0520693GO:0070993
GeneOntologyCellularComponentBMP receptor complex

ACVR1 ACVRL1

6.42e-054692GO:0070724
GeneOntologyCellularComponentactivin receptor complex

ACVR1 ACVR1B

1.60e-046692GO:0048179
GeneOntologyCellularComponentaxon

UNC13B SLC12A6 SHANK2 TENM3 SCN1B SNX18 TNK2 BSN TENM2 UNC80

6.53e-048916910GO:0030424
GeneOntologyCellularComponentpresynaptic active zone

UNC13B SHANK2 TENM3 BSN

1.22e-03141694GO:0048786
GeneOntologyCellularComponenthippocampal mossy fiber to CA3 synapse

UNC13B SHANK2 BSN

1.42e-0367693GO:0098686
DomainKCL_cotranspt

SLC12A6 SLC12A4 SLC12A7 SLC12A5

1.61e-104684IPR000076
DomainSLC12A_fam

SLC12A6 SLC12A4 SLC12A7 SLC12A5

5.58e-097684IPR004842
DomainSLC12_C

SLC12A6 SLC12A4 SLC12A7 SLC12A5

1.11e-088684IPR018491
DomainSLC12

SLC12A6 SLC12A4 SLC12A7 SLC12A5

1.11e-088684PF03522
DomainRhs_assc_core

TENM4 TENM3 TENM2

4.62e-083683IPR022385
DomainTox-GHH_dom

TENM4 TENM3 TENM2

1.84e-074683IPR028916
DomainTen_N

TENM4 TENM3 TENM2

1.84e-074683IPR009471
DomainTen_N

TENM4 TENM3 TENM2

1.84e-074683PF06484
DomainTENEURIN_N

TENM4 TENM3 TENM2

1.84e-074683PS51361
DomainTox-GHH

TENM4 TENM3 TENM2

1.84e-074683PF15636
DomainYD

TENM4 TENM3 TENM2

4.59e-075683IPR006530
DomainAA-permease/SLC12A_dom

SLC12A6 SLC12A4 SLC12A7 SLC12A5

1.12e-0622684IPR004841
DomainAA_permease

SLC12A6 SLC12A4 SLC12A7 SLC12A5

1.12e-0622684PF00324
DomainGS

ACVR1 ACVR1B ACVRL1

1.60e-067683SM00467
DomainGS_dom

ACVR1 ACVR1B ACVRL1

1.60e-067683IPR003605
DomainGS

ACVR1 ACVR1B ACVRL1

1.60e-067683PS51256
DomainTGF_beta_GS

ACVR1 ACVR1B ACVRL1

1.60e-067683PF08515
DomainTGFB_receptor

ACVR1 ACVR1B ACVRL1

9.92e-0612683IPR000333
Domain-

TENM4 TENM3 ELP1 TENM2

1.20e-05396842.120.10.30
DomainNHL

TENM4 TENM3 TENM2

1.29e-0513683PS51125
DomainKCC1

SLC12A6 SLC12A4

1.31e-052682IPR000622
DomainEIF3C_N_dom

EIF3C EIF3CL

1.31e-052682IPR008905
DomaineIF-3c_N

EIF3C EIF3CL

1.31e-052682PF05470
DomainEIF3C

EIF3C EIF3CL

1.31e-052682IPR027516
DomainSH3

SHANK2 SH3D19 SNX18 TNK2 FNBP1L DNMBP TRIP10

1.34e-05216687SM00326
DomainSH3

SHANK2 SH3D19 SNX18 TNK2 FNBP1L DNMBP TRIP10

1.34e-05216687PS50002
DomainSH3_domain

SHANK2 SH3D19 SNX18 TNK2 FNBP1L DNMBP TRIP10

1.51e-05220687IPR001452
Domain6-blade_b-propeller_TolB-like

TENM4 TENM3 ELP1 TENM2

2.34e-0546684IPR011042
DomainPINT

EIF3A EIF3C EIF3CL

2.50e-0516683SM00088
DomainSH3_1

SH3D19 SNX18 TNK2 FNBP1L DNMBP TRIP10

2.92e-05164686PF00018
DomainPCI_dom

EIF3A EIF3C EIF3CL

3.03e-0517683IPR000717
DomainPCI

EIF3A EIF3C EIF3CL

3.03e-0517683PF01399
DomainCarboxyPept-like_regulatory

TENM4 TENM3 TENM2

3.03e-0517683IPR008969
DomainIL-17_rcpt_C/E_N

IL17RE IL17RC

3.91e-053682IPR027841
DomainCul7

CUL7 HERC2

3.91e-053682PF11515
DomainTHRAP3_BCLAF1

BCLAF1 THRAP3

3.91e-053682IPR029199
DomainTHRAP3_BCLAF1

BCLAF1 THRAP3

3.91e-053682PF15440
DomainIL17_R_N

IL17RE IL17RC

3.91e-053682PF15037
DomainCPH_domain

CUL7 HERC2

3.91e-053682IPR021097
DomainMib_Herc2

HERC2 HECTD1

7.80e-054682IPR010606
DomainMIB_HERC2

HERC2 HECTD1

7.80e-054682PS51416
DomainMIB_HERC2

HERC2 HECTD1

7.80e-054682PF06701
DomainHECT

HERC2 HERC1 HECTD1

1.27e-0427683PF00632
DomainHECTc

HERC2 HERC1 HECTD1

1.27e-0427683SM00119
DomainHECT_dom

HERC2 HERC1 HECTD1

1.27e-0427683IPR000569
DomainHECT

HERC2 HERC1 HECTD1

1.27e-0427683PS50237
DomainSH3_9

SH3D19 SNX18 TNK2 DNMBP

1.87e-0478684PF14604
DomainSEFIR

IL17RE IL17RC

1.94e-046682PF08357
DomainSEFIR_dom

IL17RE IL17RC

1.94e-046682IPR013568
DomainSEFIR

IL17RE IL17RC

1.94e-046682PS51534
DomainAPC_su10/DOC_dom

CUL7 HERC2

2.71e-047682IPR004939
DomainDOC

CUL7 HERC2

2.71e-047682PS51284
DomainAPC10

CUL7 HERC2

2.71e-047682SM01337
DomainANAPC10

CUL7 HERC2

2.71e-047682PF03256
DomainSH3_2

SHANK2 SH3D19 SNX18 DNMBP

2.73e-0486684IPR011511
DomainSH3_2

SHANK2 SH3D19 SNX18 DNMBP

2.73e-0486684PF07653
DomainGalactose-bd-like

PITHD1 CUL7 HERC2 HECTD1

3.83e-0494684IPR008979
DomainProt_kinase_dom

HIPK4 TIE1 SCYL1 TNK2 ACVR1 ACVR1B ACVRL1 GRK1

3.89e-04489688IPR000719
DomainPROTEIN_KINASE_DOM

HIPK4 TIE1 SCYL1 TNK2 ACVR1 ACVR1B ACVRL1 GRK1

4.10e-04493688PS50011
DomainProtein_kinase_ATP_BS

HIPK4 TIE1 TNK2 ACVR1 ACVR1B ACVRL1 GRK1

4.48e-04379687IPR017441
DomainActivin_recp

ACVR1 ACVR1B

5.77e-0410682IPR000472
DomainActivin_recp

ACVR1 ACVR1B

5.77e-0410682PF01064
DomainKinase-like_dom

HIPK4 TIE1 SCYL1 TNK2 ACVR1 ACVR1B ACVRL1 GRK1

7.65e-04542688IPR011009
DomainEGF_extracell

TENM4 TENM3 TIE1

1.36e-0360683IPR013111
DomainEGF_2

TENM4 TENM3 TIE1

1.36e-0360683PF07974
DomainPROTEIN_KINASE_ATP

HIPK4 TIE1 TNK2 ACVR1 ACVR1B ACVRL1 GRK1

1.38e-03459687PS00107
DomainEGF_3

TENM4 TENM3 TIE1 C1S TENM2

1.65e-03235685PS50026
DomainRib_L2_dom2

CUL7 HERC2

1.92e-0318682IPR014722
Domain-

CUL7 HERC2

1.92e-03186822.30.30.30
DomainEGF-like_dom

TENM4 TENM3 TIE1 C1S TENM2

2.13e-03249685IPR000742
DomainEGF_1

TENM4 TENM3 TIE1 C1S TENM2

2.36e-03255685PS00022
DomainRCC1

HERC2 HERC1

2.38e-0320682PF00415
Domain-

CUL7 HERC2 HECTD1

2.39e-03736832.60.120.260
DomainEGF-like_CS

TENM4 TENM3 TIE1 C1S TENM2

2.61e-03261685IPR013032
DomainPkinase

HIPK4 SCYL1 ACVR1 ACVR1B ACVRL1 GRK1

2.62e-03381686PF00069
DomainRCC1_1

HERC2 HERC1

2.62e-0321682PS00625
DomainRCC1_2

HERC2 HERC1

2.62e-0321682PS00626
DomainRCC1_3

HERC2 HERC1

2.62e-0321682PS50012
DomainEGF_2

TENM4 TENM3 TIE1 C1S TENM2

2.79e-03265685PS01186
DomainFCH

FNBP1L TRIP10

2.88e-0322682PF00611
DomainReg_chr_condens

HERC2 HERC1

2.88e-0322682IPR000408
Domain-

HERC2 HERC1

2.88e-03226822.130.10.30
DomainFCH

FNBP1L TRIP10

2.88e-0322682SM00055
DomainFCH_dom

FNBP1L TRIP10

3.15e-0323682IPR001060
DomainRCC1/BLIP-II

HERC2 HERC1

3.15e-0323682IPR009091
PathwayREACTOME_CATION_COUPLED_CHLORIDE_COTRANSPORTERS

SLC12A6 SLC12A4 SLC12A7 SLC12A5

6.67e-097544M27339
PathwayREACTOME_CATION_COUPLED_CHLORIDE_COTRANSPORTERS

SLC12A6 SLC12A4 SLC12A7 SLC12A5

6.67e-097544MM15081
Pubmed

Influence of K-Cl cotransporter activity on activation of volume-sensitive Cl- channels in human osteoblasts.

SLC12A6 SLC12A4 SLC12A7 SLC12A5

1.50e-11470412637262
Pubmed

Potential target genes of EMX2 include Odz/Ten-M and other gene families with implications for cortical patterning.

PITHD1 TENM4 TENM3 EIF3C TENM2 EIF3CL

8.95e-105170616919471
Pubmed

Disruption of KCC2 reveals an essential role of K-Cl cotransport already in early synaptic inhibition.

SLC12A6 SLC12A4 SLC12A7 SLC12A5

1.05e-09870411395011
Pubmed

The WNK-regulated SPAK/OSR1 kinases directly phosphorylate and inhibit the K+-Cl- co-transporters.

SLC12A6 SLC12A4 SLC12A7 SLC12A5

1.05e-09870424393035
Pubmed

Similar effects of all WNK3 variants on SLC12 cotransporters.

SLC12A6 SLC12A4 SLC12A7 SLC12A5

1.05e-09870421613606
Pubmed

Cation-chloride cotransporters and neuronal function.

SLC12A6 SLC12A4 SLC12A7 SLC12A5

1.88e-09970419323993
Pubmed

A dominant negative mutant of the KCC1 K-Cl cotransporter: both N- and C-terminal cytoplasmic domains are required for K-Cl cotransport activity.

SLC12A6 SLC12A4 SLC12A7

7.81e-09370311551954
Pubmed

Insulin-like growth factor 1 stimulates KCl cotransport, which is necessary for invasion and proliferation of cervical cancer and ovarian cancer cells.

SLC12A6 SLC12A4 SLC12A7

7.81e-09370315262997
Pubmed

K-Cl cotransporter gene expression during human and murine erythroid differentiation.

SLC12A6 SLC12A4 SLC12A7

7.81e-09370321733850
Pubmed

Mouse ten-m/Odz is a new family of dimeric type II transmembrane proteins expressed in many tissues.

TENM4 TENM3 TENM2

3.12e-08470310225957
Pubmed

All four members of the Ten-m/Odz family of transmembrane proteins form dimers.

TENM4 TENM3 TENM2

3.12e-08470312000766
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

UNC13B PLOD3 SHANK2 SLC12A4 IL17RE SHC1 TNK2 TNKS1BP1 HERC2 HERC1 DNMBP HECTD1 C8orf58 TRIM7

3.63e-081105701435748872
Pubmed

Activin receptor-like kinases: a novel subclass of cell-surface receptors with predicted serine/threonine kinase activity.

ACVR1 ACVR1B ACVRL1

7.79e-0857038397373
Pubmed

Rare independent mutations in renal salt handling genes contribute to blood pressure variation.

SLC12A6 SLC12A4 SLC12A7 SLC12A5

1.07e-072270418391953
Pubmed

KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.

SLC12A6 TENM4 SHANK2 BCLAF1 ELP1 YTHDC2 TNKS1BP1 EIF3A EIF3C BSN PBXIP1 THRAP3 HNRNPH1 EIF3CL SLC12A5

1.31e-071431701537142655
Pubmed

Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.

PLOD3 BCLAF1 SNX18 ELP1 YTHDC2 HERC2 HECTD1 TRIP10 HNRNPH1

2.52e-0744070934244565
Pubmed

SB-431542 is a potent and specific inhibitor of transforming growth factor-beta superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7.

ACVR1 ACVR1B ACVRL1

2.72e-07770312065756
Pubmed

The mammalian Odz gene family: homologs of a Drosophila pair-rule gene with expression implying distinct yet overlapping developmental roles.

TENM4 TENM3 TENM2

2.72e-07770310625539
Pubmed

The murine Ten-m/Odz genes show distinct but overlapping expression patterns during development and in adult brain.

TENM4 TENM3 TENM2

2.72e-07770312915301
Pubmed

Mapping homologs of Drosophila odd Oz (odz): Doc4/Odz4 to mouse chromosome 7, Odz1 to mouse chromosome 11; and ODZ3 to human chromosome Xq25.

TENM4 TENM3 TENM2

4.34e-07870310331952
Pubmed

Cation chloride cotransporters interact with the stress-related kinases Ste20-related proline-alanine-rich kinase (SPAK) and oxidative stress response 1 (OSR1).

SLC12A6 SLC12A4 SLC12A7

4.34e-07870312386165
Pubmed

Tandem immunoprecipitation of phosphotyrosine-mass spectrometry (TIPY-MS) indicates C19ORF19 becomes tyrosine-phosphorylated and associated with activated epidermal growth factor receptor.

BCLAF1 SHC1 TNK2 HNRNPH1

5.89e-073370418271526
Pubmed

The pleiotropic mouse phenotype extra-toes spotting is caused by translation initiation factor Eif3c mutations and is associated with disrupted sonic hedgehog signaling.

EIF3A EIF3C EIF3CL

6.50e-07970321292980
Pubmed

The m subunit of murine translation initiation factor eIF3 maintains the integrity of the eIF3 complex and is required for embryonic development, homeostasis, and organ size control.

EIF3A EIF3C EIF3CL

6.50e-07970324003236
Pubmed

Loss of K-Cl co-transporter KCC3 causes deafness, neurodegeneration and reduced seizure threshold.

SLC12A6 SLC12A7 SLC12A5

6.50e-07970314532115
Pubmed

Human retroviral gag- and gag-pol-like proteins interact with the transforming growth factor-beta receptor activin receptor-like kinase 1.

ACVR1 ACVR1B ACVRL1

9.28e-071070315611116
Pubmed

Conservation and diversity of eukaryotic translation initiation factor eIF3.

EIF3A EIF3C EIF3CL

9.28e-07107038995409
Pubmed

Cartography of teneurin and latrophilin expression reveals spatiotemporal axis heterogeneity in the mouse hippocampus during development.

TENM4 TENM3 TENM2

9.28e-071070338713721
Pubmed

Modulation of activin signal transduction by inhibin B and inhibin-binding protein (INhBP).

ACVR1 ACVR1B ACVRL1

9.28e-071070311266516
Pubmed

Human BAMBI cooperates with Smad7 to inhibit transforming growth factor-beta signaling.

ACVR1 ACVR1B ACVRL1

1.27e-061170319758997
Pubmed

Characterization of eIF3k: a newly discovered subunit of mammalian translation initiation factor elF3.

EIF3A EIF3C EIF3CL

1.70e-061270314519125
Pubmed

Reconstitution reveals the functional core of mammalian eIF3.

EIF3A EIF3C EIF3CL

1.70e-061270317581632
Pubmed

Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity.

PLOD3 BCLAF1 SHC1 SCYL1 TNK2 EIF3C ACVR1 ACVR1B CUL7 THRAP3 EIF3CL

1.96e-06910701136736316
Pubmed

A Global Analysis of the Receptor Tyrosine Kinase-Protein Phosphatase Interactome.

SHANK2 TIE1 BCLAF1 SHC1 SCYL1 HERC2 HERC1 UNC80

2.08e-0642070828065597
Pubmed

Kelch Domain of Gigaxonin Interacts with Intermediate Filament Proteins Affected in Giant Axonal Neuropathy.

TENM3 BCLAF1 EIF3A EIF3C THRAP3 HNRNPH1

2.20e-0618770626460568
Pubmed

TSC-22 promotes transforming growth factor β-mediated cardiac myofibroblast differentiation by antagonizing Smad7 activity.

ACVR1 ACVR1B ACVRL1

2.80e-061470321791611
Pubmed

Mass spectrometry reveals modularity and a complete subunit interaction map of the eukaryotic translation factor eIF3.

EIF3A EIF3C EIF3CL

2.80e-061470318599441
Pubmed

Structural characterization of the human eukaryotic initiation factor 3 protein complex by mass spectrometry.

EIF3A EIF3C EIF3CL

3.49e-061570317322308
Pubmed

Functional specialization of beta-arrestin interactions revealed by proteomic analysis.

PRPF4 BCLAF1 CPNE1 BSN RGS3 THRAP3 HNRNPH1

3.59e-0631770717620599
Pubmed

Differences in the large extracellular loop between the K(+)-Cl(-) cotransporters KCC2 and KCC4.

SLC12A7 SLC12A5

3.99e-06270220516068
Pubmed

Phospho-regulation, nucleotide binding and ion access control in potassium-chloride cotransporters.

SLC12A6 SLC12A4

3.99e-06270234031912
Pubmed

Molecular, functional, and genomic characterization of human KCC2, the neuronal K-Cl cotransporter.

SLC12A7 SLC12A5

3.99e-06270212106695
Pubmed

Genomic organization of a mouse type I activin receptor.

ACVR1 ACVR1B

3.99e-0627027639738
Pubmed

Tuba stimulates intracellular N-WASP-dependent actin assembly.

FNBP1L DNMBP

3.99e-06270216757518
Pubmed

Teneurins assemble into presynaptic nanoclusters that promote synapse formation via postsynaptic non-teneurin ligands.

TENM4 TENM3

3.99e-06270235484136
Pubmed

Functional and biochemical characterization of human eukaryotic translation initiation factor 3 in living cells.

EIF3A EIF3C

3.99e-06270224912683
Pubmed

SLC12A ion transporter mutations in sporadic and familial human congenital hydrocephalus.

SLC12A6 SLC12A7

3.99e-06270231393094
Pubmed

EIF3C Promotes Lung Cancer Tumorigenesis by Regulating the APP/HSPA1A/LMNB1 Axis.

EIF3C EIF3CL

3.99e-06270236157221
Pubmed

Disruption of erythroid K-Cl cotransporters alters erythrocyte volume and partially rescues erythrocyte dehydration in SAD mice.

SLC12A6 SLC12A4

3.99e-06270217510708
Pubmed

Cloning and characterization of KCC3 and KCC4, new members of the cation-chloride cotransporter gene family.

SLC12A6 SLC12A7

3.99e-06270210347194
Pubmed

Btf and TRAP150 have distinct roles in regulating subcellular mRNA distribution.

BCLAF1 THRAP3

3.99e-06270223778535
Pubmed

The RNA processing factors THRAP3 and BCLAF1 promote the DNA damage response through selective mRNA splicing and nuclear export.

BCLAF1 THRAP3

3.99e-06270229112714
Pubmed

Chromosomal localization of three human genes encoding members of the TGF-beta superfamily of type I serine/threonine kinase receptors.

ACVR1 ACVR1B

3.99e-0627029501322
Pubmed

Genetic disruption of KCC cotransporters in a mouse model of thalassemia intermedia.

SLC12A6 SLC12A4

3.99e-06270231835175
Pubmed

A high-throughput approach for measuring temporal changes in the interactome.

CDAN1 PRPF4 SCYL1 ELP1 TNKS1BP1 EIF3A EIF3C HERC1 DNMBP HECTD1 TRIP10 HNRNPH1 EIF3CL

5.85e-061455701322863883
Pubmed

Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations.

SHANK2 CPNE1 TNKS1BP1 EIF3C FNBP1L BSN EIF3CL

6.48e-0634770717114649
Pubmed

USP45 and Spindly are part of the same complex implicated in cell migration.

BCLAF1 EIF3A EIF3C KCNAB3 THRAP3 HNRNPH1

8.16e-0623570630258100
Pubmed

Loss of mouse Ikbkap, a subunit of elongator, leads to transcriptional deficits and embryonic lethality that can be rescued by human IKBKAP.

ANGPT2 TIE1 ELP1

1.01e-052170319015235
Pubmed

The protein interaction landscape of the human CMGC kinase group.

SHANK2 HIPK4 PRPF4 BCLAF1 TRIM41 TNKS1BP1 CUL7 HERC2 THRAP3

1.06e-0569570923602568
Pubmed

PROTAC-mediated degradation reveals a non-catalytic function of AURORA-A kinase.

PITHD1 SCYL1 TNKS1BP1 HERC2 HECTD1 THRAP3

1.08e-0524770632989298
Pubmed

Global mapping of herpesvirus-host protein complexes reveals a transcription strategy for late genes.

PRPF4 BCLAF1 TRIM41 SNX18 TNKS1BP1 HERC2 THRAP3 B3GAT3

1.18e-0553370825544563
Pubmed

Combined genetic disruption of K-Cl cotransporters and Gardos channel KCNN4 rescues erythrocyte dehydration in the SAD mouse model of sickle cell disease.

SLC12A6 SLC12A4

1.20e-05370231352162
Pubmed

Tie1 regulates the Tie2 agonistic role of angiopoietin-2 in human lymphatic endothelial cells.

ANGPT2 TIE1

1.20e-05370222342979
Pubmed

The role of activin type I receptors in activin A-induced growth arrest and apoptosis in mouse B-cell hybridoma cells.

ACVR1 ACVR1B

1.20e-0537029884026
Pubmed

IGF-1 upregulates electroneutral K-Cl cotransporter KCC3 and KCC4 which are differentially required for breast cancer cell proliferation and invasiveness.

SLC12A6 SLC12A7

1.20e-05370217133354
Pubmed

Erythroid-specific inactivation of Slc12a6/Kcc3 by EpoR promoter-driven Cre expression reduces K-Cl cotransport activity in mouse erythrocytes.

SLC12A6 SLC12A4

1.20e-05370235274823
Pubmed

Raising cytosolic Cl- in cerebellar granule cells affects their excitability and vestibulo-ocular learning.

SLC12A6 SLC12A5

1.20e-05370222252133
Pubmed

TGFbeta/BMP type I receptors ALK1 and ALK2 are essential for BMP9-induced osteogenic signaling in mesenchymal stem cells.

ACVR1 ACVRL1

1.20e-05370220628059
Pubmed

Dynamin and the actin cytoskeleton cooperatively regulate plasma membrane invagination by BAR and F-BAR proteins.

FNBP1L TRIP10

1.20e-05370216326391
Pubmed

IL-17 Receptor Signaling in the Lung Epithelium Is Required for Mucosal Chemokine Gradients and Pulmonary Host Defense against K. pneumoniae.

IL17RE IL17RC

1.20e-05370227923703
Pubmed

Molecular evidence for a role for K(+)-Cl(-) cotransporters in the kidney.

SLC12A6 SLC12A7

1.20e-05370224089410
Pubmed

Molecular physiology of cation-coupled Cl- cotransport: the SLC12 family.

SLC12A4 SLC12A5

1.20e-05370212739168
Pubmed

Tie1 controls angiopoietin function in vascular remodeling and inflammation.

ANGPT2 TIE1

1.20e-05370227548530
Pubmed

Ammonium transport and pH regulation by K(+)-Cl(-) cotransporters.

SLC12A6 SLC12A7

1.20e-05370212657561
Pubmed

Local anesthetics impair the growth and self-renewal of glioblastoma stem cells by inhibiting ZDHHC15-mediated GP130 palmitoylation.

TENM4 ACVR1B PBXIP1 UNC80

1.32e-057170433541421
Pubmed

Preferred SH3 domain partners of ADAM metalloproteases include shared and ADAM-specific SH3 interactions.

SNX18 FNBP1L TRIP10

1.53e-052470325825872
Pubmed

Nuclear control of lung cancer cells migration, invasion and bioenergetics by eukaryotic translation initiation factor 3F.

BCLAF1 EIF3A EIF3C EIF3CL

1.64e-057570431527668
Pubmed

mTORC1 activity regulates post-translational modifications of glycine decarboxylase to modulate glycine metabolism and tumorigenesis.

PLOD3 BCLAF1 SCYL1 EIF3A THRAP3 HNRNPH1

1.95e-0527470634244482
Pubmed

System-Wide Modulation of HECT E3 Ligases with Selective Ubiquitin Variant Probes.

HERC2 HERC1 HECTD1

1.96e-052670326949039
Pubmed

Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms.

SUMF2 PLOD3 YTHDC2 EIF3A EIF3C HERC2 HECTD1 PBXIP1 B3GAT3

2.02e-0575470933060197
Pubmed

Assembly of the U5 snRNP component PRPF8 is controlled by the HSP90/R2TP chaperones.

PLOD3 PRPF4 SHC1 ELP1 TNKS1BP1 EIF3A EIF3C FNBP1L HECTD1 TRIP10 THRAP3 HNRNPH1

2.35e-051415701228515276
Pubmed

BMP type I receptor ALK2 is required for angiotensin II-induced cardiac hypertrophy.

ACVR1 ACVRL1

2.39e-05470226873969
Pubmed

Endothelial exocytosis of angiopoietin-2 resulting from CCM3 deficiency contributes to cerebral cavernous malformation.

UNC13B ANGPT2

2.39e-05470227548575
Pubmed

The distribution of angiopoietin-1, angiopoietin-2 and their receptors tie-1 and tie-2 in the very early human placenta.

ANGPT2 TIE1

2.39e-05470218675456
Pubmed

The physiology and pathophysiology of inhibin, activin and follistatin in female reproduction.

ACVR1 ACVR1B

2.39e-05470212032389
Pubmed

Interaction between the Ret finger protein and the Int-6 gene product and co-localisation into nuclear bodies.

EIF3C EIF3CL

2.39e-05470210504338
Pubmed

Activin A accelerates the progression of fetal oocytes throughout meiosis and early oogenesis in the mouse.

ACVR1 ACVR1B

2.39e-05470226083127
Pubmed

The diaphanous-related formin DAAM1 collaborates with the Rho GTPases RhoA and Cdc42, CIP4 and Src in regulating cell morphogenesis and actin dynamics.

FNBP1L TRIP10

2.39e-05470216630611
Pubmed

Signaling and functions of angiopoietin-1 in vascular protection.

ANGPT2 TIE1

2.39e-05470216645151
Pubmed

Signaling through IL-17C/IL-17RE is dispensable for immunity to systemic, oral and cutaneous candidiasis.

IL17RE IL17RC

2.39e-05470225849644
Pubmed

X-linked inhibitor of apoptosis protein functions as a cofactor in transforming growth factor-beta signaling.

ACVR1B ACVRL1

2.39e-05470211356828
Pubmed

Alk2/ACVR1 and Alk3/BMPR1A Provide Essential Function for Bone Morphogenetic Protein-Induced Retinal Angiogenesis.

ACVR1 ACVRL1

2.39e-05470228232325
Pubmed

Tyrosine phosphorylation of ACK in response to temperature shift-down, hyperosmotic shock, and epidermal growth factor stimulation.

SHC1 TNK2

2.39e-0547028647288
Pubmed

A neurogenomics approach to gene expression analysis in the developing brain.

ANGPT2 EIF3C THRAP3 HNRNPH1 EIF3CL

2.46e-0517070515582152
Pubmed

Large-scale characterization of HeLa cell nuclear phosphoproteins.

BCLAF1 BRPF1 YTHDC2 TNKS1BP1 EIF3C DNMBP THRAP3 HNRNPH1 EIF3CL

2.47e-0577470915302935
Pubmed

HERC2 Facilitates BLM and WRN Helicase Complex Interaction with RPA to Suppress G-Quadruplex DNA.

EIF3A EIF3C HERC2

3.37e-053170330279242
Pubmed

Identifying biological pathways that underlie primordial short stature using network analysis.

PRPF4 BCLAF1 ELP1 YTHDC2 EIF3A EIF3C CUL7 HERC2 THRAP3 HNRNPH1

3.75e-051024701024711643
Pubmed

Sites of regulated phosphorylation that control K-Cl cotransporter activity.

SLC12A6 SLC12A5

3.98e-05570219665974
Pubmed

The distribution of activin and activin receptors in gestational tissues across human pregnancy and during labour.

ACVR1 ACVR1B

3.98e-05570211969340
Pubmed

Changes in ribosomal binding activity of eIF3 correlate with increased translation rates during activation of T lymphocytes.

EIF3A EIF3C

3.98e-05570215946946
InteractionIGSF1 interactions

ACVR1 ACVR1B ACVRL1 HECTD1

1.77e-0715704int:IGSF1
InteractionSLC12A4 interactions

SLC12A6 SLC12A4 IL17RC SLC12A7 HNRNPH1 SLC12A5

5.74e-06129706int:SLC12A4
InteractionBAMBI interactions

ACVR1 ACVR1B ACVRL1

1.77e-0515703int:BAMBI
InteractionINHBB interactions

ACVR1 ACVR1B HNRNPH1

3.15e-0518703int:INHBB
InteractionLYN interactions

SLC12A6 ANGPT2 SLC12A4 PRPF4 SH3D19 SHC1 TNK2 TNKS1BP1 SLC12A7 TRIP10 THRAP3

3.55e-057207011int:LYN
InteractionEIF3M interactions

SCYL1 EIF3A EIF3C CUL7 HERC2 EIF3CL

4.06e-05182706int:EIF3M
InteractionSLC12A5 interactions

SLC12A4 SLC12A7 SLC12A5

5.10e-0521703int:SLC12A5
InteractionRBM6 interactions

PLOD3 CUL7 HECTD1 THRAP3 HNRNPH1

5.88e-05119705int:RBM6
InteractionCLK2 interactions

PRPF4 BCLAF1 HERC2 RGS3 THRAP3 HNRNPH1

5.96e-05195706int:CLK2
InteractionDNM2 interactions

SHANK2 SH3D19 SNX18 SHC1 FNBP1L DNMBP TRIP10

6.29e-05288707int:DNM2
InteractionZDHHC12 interactions

SLC12A6 SLC12A4 ACVR1B SLC12A7 B3GAT3

6.88e-05123705int:ZDHHC12
InteractionMAP4K1 interactions

BCLAF1 SHC1 CUL7 THRAP3 HNRNPH1

8.94e-05130705int:MAP4K1
InteractionSMURF1 interactions

BCLAF1 SCYL1 TNK2 EIF3A ACVR1 ACVR1B TRIP10 THRAP3 HNRNPH1

1.07e-04544709int:SMURF1
InteractionASB18 interactions

BCLAF1 THRAP3 HNRNPH1

1.11e-0427703int:ASB18
InteractionTOP3B interactions

UNC13B PLOD3 SHANK2 SLC12A4 IL17RE TRIM41 SHC1 TNK2 TNKS1BP1 HERC2 HERC1 DNMBP HECTD1 C8orf58 TRIM7

1.29e-0414707015int:TOP3B
InteractionINHBA interactions

ACVR1 ACVR1B ACVRL1

1.37e-0429703int:INHBA
InteractionCDK12 interactions

PRPF4 BCLAF1 HERC2 ACVRL1 HECTD1 THRAP3

1.41e-04228706int:CDK12
InteractionZNF223 interactions

TRIM41 HERC1 HECTD1

1.52e-0430703int:ZNF223
InteractionTMC4 interactions

SLC12A6 SLC12A4 SLC12A7

1.52e-0430703int:TMC4
InteractionCDC42 interactions

SLC12A4 TENM3 SH3D19 SCYL1 CPNE1 TNK2 FNBP1L HERC2 SLC12A7 DNMBP TRIP10 THRAP3 HNRNPH1 EIF3CL

1.55e-0413237014int:CDC42
InteractionRAB5A interactions

SLC12A6 SLC12A4 BCLAF1 SH3D19 EIF3A EIF3C HERC2 SLC12A7 THRAP3 EIF3CL

1.55e-047067010int:RAB5A
Cytoband15q13

SLC12A6 HERC2

8.19e-05970215q13
Cytoband5q35.3

TRIM41 HNRNPH1 TRIM7

4.25e-04957035q35.3
Cytoband10q24.2

MORN4 DNMBP

5.19e-042270210q24.2
CytobandEnsembl 112 genes in cytogenetic band chr3p25

IL17RE BRPF1 IL17RC

1.75e-03155703chr3p25
Cytoband3p25.3

IL17RE IL17RC

2.17e-03457023p25.3
CytobandEnsembl 112 genes in cytogenetic band chr9q32

PRPF4 RGS3

2.68e-0350702chr9q32
CytobandEnsembl 112 genes in cytogenetic band chr11q13

CATSPERZ SHANK2 UCP2 SCYL1

5.18e-03454704chr11q13
CytobandEnsembl 112 genes in cytogenetic band chr5q35

TRIM41 HNRNPH1 TRIM7

5.63e-03235703chr5q35
GeneFamilyType 1 receptor serine/threonine kinases

ACVR1 ACVR1B ACVRL1

4.67e-077443345
GeneFamilyEukaryotic translation initiation factor 3

EIF3A EIF3C

4.44e-04134421121
GeneFamilyRho GTPase activating proteins|F-BAR domain containing

FNBP1L TRIP10

1.42e-03234421288
GeneFamilySolute carriers

SLC12A6 SLC12A4 UCP2 SLC12A7 SLC12A5

2.62e-03395445752
GeneFamilyCD molecules|I-set domain containing|Immunoglobulin like domain containing|Interleukin receptors|TIR domain containing

IL17RE IL17RC

4.68e-0342442602
CoexpressionGSE17580_TREG_VS_TEFF_DN

SCYL1 CPNE1 ACVR1B ACVRL1 SLC12A7 APOBR THRAP3

1.08e-06200707M3671
CoexpressionGSE26669_CD4_VS_CD8_TCELL_IN_MLR_UP

GPRASP1 ANGPT2 GCAT TNFRSF18 ACVR1B UNC80

1.60e-05200706M4668
CoexpressionFOSTER_KDM1A_TARGETS_DN

GCAT SHC1 SCYL1 EIF3C CUL7 EIF3CL

1.84e-05205706MM957
CoexpressionMILI_PSEUDOPODIA_CHEMOTAXIS_DN

TENM4 SLC12A4 BCLAF1 C1S ACVR1 RGS3 THRAP3 GAA

2.94e-05457708M1613
CoexpressionMILI_PSEUDOPODIA_CHEMOTAXIS_DN

TENM4 SLC12A4 BCLAF1 C1S ACVR1 RGS3 THRAP3 GAA

3.59e-05470708MM1053
ToppCellfacs-Brain_Non-Myeloid-Cortex-3m-Neuronal-neuron|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TENM4 SHANK2 BSN TENM2 UNC80 SLC12A5

6.02e-07193706461919ab422bc9d1fcff7a3a4757c75239041d7e
ToppCellfacs-Brain_Non-Myeloid-Cortex-3m-Neuronal-nan|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TENM4 SHANK2 BSN TENM2 UNC80 SLC12A5

6.02e-071937060dd810ad900d3e586551622b2c1de39d76fd6a7f
ToppCellHippocampus-Neuronal|Hippocampus / BrainAtlas - Mouse McCarroll V32

GPRASP1 HERC2 HERC1 BSN UNC80 SLC12A5

6.20e-071947068aeb347b3024354c9505f4f0fddf0b843489dc6b
ToppCelldroplet-Heart-nan-24m-Endothelial-endocardial_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

UNC13B TIE1 ACVR1 RGS3 GAA

1.23e-051907057068754c29f63a331e2b6c54715f3b26f37ad32b
ToppCellGlobus_pallidus-Neuronal|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

GPRASP1 BSN TENM2 UNC80 SLC12A5

1.23e-05190705416de85d8841dac883faa6f5339b2fb461a09e82
ToppCelldroplet-Heart-4Chambers-18m-Endothelial-endocardial_endothelial_cells|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

UNC13B TIE1 SHC1 SLC12A7 RGS3

1.23e-051907056f71a9f74af7cd9a674753cfc9833ebe5bba0fa2
ToppCellEntopeduncular-Neuronal|Entopeduncular / BrainAtlas - Mouse McCarroll V32

SHANK2 BSN TENM2 UNC80 SLC12A5

1.30e-051927054c35e5c28a40b439044797ba1f06cb7c36b2a8de
ToppCellThalamus-Neuronal|Thalamus / BrainAtlas - Mouse McCarroll V32

GPRASP1 BSN TENM2 B3GAT3 SLC12A5

1.33e-05193705712a4acd1167e43543950bc819ff11984e6f718d
ToppCellPosterior_cortex-Neuronal|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

GPRASP1 HERC1 BSN UNC80 SLC12A5

1.33e-05193705b4989e3436e84dbec3789b46057e0f7a0ebf09d4
ToppCellfacs-Heart-RA-18m-Mesenchymal|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TENM3 SCN1B SH3D19 SNX18 C1S

1.36e-05194705bc945450b350f597c3ff910d3a14a533d90086a8
ToppCellfacs-Heart-RA-18m-Mesenchymal-fibroblast_of_cardiac_tissue|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TENM3 SCN1B SH3D19 SNX18 C1S

1.40e-05195705690d6e15d7c863fc8f2d33b1f7bf86f019f415c9
ToppCellfacs-Brain_Non-Myeloid-Cortex-3m-Neuronal|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TENM4 BSN TENM2 UNC80 SLC12A5

1.40e-05195705ffbab350e67d9c4b66c0ab84550daec8b8139a27
ToppCellfacs-Heart-RA-18m-Mesenchymal-fibroblast_of_cardiac_tissue|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TENM3 SCN1B SH3D19 SNX18 C1S

1.40e-051957055c05e2bcea3d5d7ebe6325f7187ccf83301053d8
ToppCellStriatum-Neuronal|Striatum / BrainAtlas - Mouse McCarroll V32

GPRASP1 SCN1B HERC1 BSN SLC12A5

1.58e-05200705c888fd487990cad482a4ca47601cdebc0ca3f3ce
ToppCellNeuronal|World / cells hierarchy compared to all cells using T-Statistic

SHANK2 HERC1 TENM2 UNC80 SLC12A5

1.58e-0520070548d801219bc771d6c7e151dc88ca4c179988de85
ToppCellIIH-CD8-proli_CD4|IIH / Condition, Cell_class and T cell subcluster

MORN4 IL17RE TNKS1BP1 KCNAB3

8.26e-051467047fa6e35def3f7cffbee1e1c2f10b523bab678e14
ToppCellIIH-CD4-CD4_Treg|IIH / Condition, Cell_class and T cell subcluster

TNFRSF18 KCNAB3 PBXIP1 TRIM7

9.90e-0515370428fb5d9f66f58741a5d43df004f80da3d910682e
ToppCell390C-Lymphocytic-NK_cells-NK_cell_E|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

IL17RE SCN1B TNFRSF18 CUL7

1.39e-041677046c2dade24a88af04b2c90a7e4f8dd7ccea9e94d1
ToppCellfacs-Heart-RA-18m-Endothelial-endothelial_cell_of_endocardium|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

UNC13B TIE1 ACVR1 RGS3

1.42e-0416870406dc5b2d356d3a9454b10bba6f3b9ead2a0a7d46
ToppCellfacs-Heart-RA-18m-Endothelial-endocardial_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

UNC13B TIE1 ACVR1 RGS3

1.42e-041687041002f058a340763e3d8de0bd1f0547a903526ec6
ToppCellfacs-Heart-LV-18m-Mesenchymal|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TENM4 SCN1B SNX18 C1S

1.45e-04169704849a8f8509c58d65462a09c84d58b6ecdc8934f5
ToppCell3'_v3-lymph-node_spleen-Myeloid_Dendritic-migDC|lymph-node_spleen / Manually curated celltypes from each tissue

UNC13B TENM3 TRIP10 TENM2

1.55e-041727041b24bed3cd8e3fa463c5e7cefdf9e99e639e2f84
ToppCellPND01-03-samps-Endothelial-Postnatal_endothelial-endothelial_cells_D|PND01-03-samps / Age Group, Lineage, Cell class and subclass

TIE1 FNBP1L ACVRL1 RGS3

1.62e-04174704b4f3f5334803e5903bc496decf923f2e44f7fa3c
ToppCelldroplet-Mammary_Gland-nan-21m-Endothelial-basal_cell|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TENM3 TIE1 C8orf58 SLC12A5

1.70e-0417670427e5115fae5f0f63b333bc99fbf6a6d4c9182c46
ToppCellRSV-Healthy-0|RSV / Virus stimulation, Condition and Cluster

TRIM41 BRPF1 UCP2 PBXIP1

1.85e-04180704974044056e2f7e909cb11c6f6ca89e58bf95f7e5
ToppCellRSV-Healthy-0|Healthy / Virus stimulation, Condition and Cluster

TRIM41 BRPF1 UCP2 PBXIP1

1.85e-04180704703a1d0f9536af94d56757eb01221878d7b7fe61
ToppCellfacs-Brain_Non-Myeloid-Cerebellum_-18m-Neuronal-neuron|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SCN1B KCNAB3 UNC80 SLC12A5

1.85e-041807043d54cc767e25d91ed2203d8a03e5bf5e15f21699
ToppCell5'-Parenchyma_lung-Endothelial-Lymphatic_EC-endothelial_cell_of_lymphatic_vessel-Lymphatic_EC_differentiating-Lymphatic_EC_differentiating_L.2.5.1.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ANGPT2 TENM3 TIE1 SHC1

1.93e-0418270453c267ee327e116dbd89d5927ed3bdf78d25ee62
ToppCellfacs-Lung-nan-3m-Endothelial-Artery_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

UNC13B TIE1 ACVR1 SLC12A7

1.97e-0418370412e876d6205af8aad74265c668b5e95b9e7487f3
ToppCell5'-Parenchyma_lung-Endothelial-Lymphatic_EC-endothelial_cell_of_lymphatic_vessel-Lymphatic_EC_differentiating-Lymphatic_EC_differentiating_L.2.5.1.1|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ANGPT2 TENM3 TIE1 SHC1

1.97e-041837044d16bfbadf2cd13008c35e23dd2b5b4ecf92ee11
ToppCelldroplet-Heart-4Chambers-18m-Endothelial-endocardial_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

UNC13B TIE1 SLC12A7 RGS3

1.97e-041837046c4a09c02e30e1f24dde39f8cb8c5b453826ee2e
ToppCell3'_v3-bone_marrow-Hematopoietic_Erythro-Mega-Mega-Mast|bone_marrow / Manually curated celltypes from each tissue

MORN4 IL17RE FNBP1L TRIP10

2.01e-04184704030d5ef5e44e4d973862128fe01f7e8ef0092a06
ToppCellfacs-Brain_Non-Myeloid-Cerebellum_-18m-Neuronal|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SCN1B BSN UNC80 SLC12A5

2.01e-041847047d9bcdaff8cbea4c50ab7db0f8e01f6bbd0ef593
ToppCellPCW_13-14-Mesenchymal-Mesenchymal_fibroblastic-mes_Arw_fibro_(16)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

TENM4 TENM3 TENM2 UNC80

2.05e-041857047dcdc009c5681ee05dd18968f7e85c3403fe34af
ToppCellCOVID-19-Epithelial_cells-Airway_club|COVID-19 / group, cell type (main and fine annotations)

UNC13B SHANK2 FNBP1L B4GALNT3

2.05e-04185704cfe6fd73d817e173fe803bc1683c291d9bcb8608
ToppCell5'-Parenchyma_lung-Endothelial-Lymphatic_EC-endothelial_cell_of_lymphatic_vessel-Lymphatic_EC_differentiating|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ANGPT2 TENM3 TIE1 SHC1

2.10e-0418670440070d9cd20188ba49b32acfca9bc16256b38bf5
ToppCellfacs-Brain_Non-Myeloid-Cortex_-18m-Endothelial-Endothelial_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TIE1 UCP2 FNBP1L ACVRL1

2.10e-04186704a58c9d1567da0961e0e295a156773d2252ee5a1a
ToppCellSubstantia_nigra-Neuronal|Substantia_nigra / BrainAtlas - Mouse McCarroll V32

BSN TENM2 UNC80 SLC12A5

2.10e-041867043f889083fcffe516388e9b03a5e23af2010ced33
ToppCellPCW_10-12-Mesenchymal-Mesenchymal_fibroblastic-mes_Arw_fibro_(16)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

TENM4 TENM3 TENM2 UNC80

2.14e-041877045258674d0346e5c51a4b965efcdc1790c970845d
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Endothelial-endothelial_cell|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TIE1 SCN1B TNKS1BP1 FNBP1L

2.14e-041877043548a9914c2b2f5d805798ce22ab26eab6d03897
ToppCelltumor_Lung-Endothelial_cells-Lymphatic_ECs|tumor_Lung / Location, Cell class and cell subclass

ANGPT2 TENM3 TIE1 SHC1

2.14e-0418770487ecdc5f24aced95a37e653429f0fc493ff4aa3e
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Endothelial-endothelial_cell|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TIE1 SCN1B TNKS1BP1 FNBP1L

2.14e-04187704f4de4b7af1fdfbd628b1f509c060c1079d2e5437
ToppCellfacs-Brain_Non-Myeloid-Cerebellum_-18m-Neuronal-interneuron|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SCN1B BSN UNC80 SLC12A5

2.14e-041877041b2fdbfb1ce3f19795dfc4b1da5a94f4b057ec41
ToppCellkidney_cells-Hypertensive_with+without-CKD-Endothelial-lymphatic_endothelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ANGPT2 TIE1 SHC1 ACVRL1

2.14e-0418770465d406122dffe18279f14a1ed35ba091730b97be
ToppCellkidney_cells-Hypertensive_with+without-CKD-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_cortex-lymphatic_endothelial_cell_of_renal_cortex|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ANGPT2 TIE1 SHC1 ACVRL1

2.14e-041877044c15c0ed41a55271fc793cb76fee97fa64190369
ToppCellfacs-Brain_Non-Myeloid-Hippocampus-24m-Neuronal-neuron|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HIPK4 SCN1B BSN TENM2

2.14e-04187704e04a84989d624378141042768383b9c846901f2d
ToppCellfacs-Brain_Non-Myeloid-Hippocampus-24m-Neuronal-nan|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HIPK4 SCN1B BSN TENM2

2.14e-0418770424cc03c748e15f7ef0e6509ca5a6ca583fb9c573
ToppCellfacs-Lung-3m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell-pulmonary_artery_endothelial_cell_l25|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

TIE1 SLC12A7 RGS3 SLC12A5

2.14e-041877047170694a1b86fe8d84d96c880ffe57af09bdc026
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Endothelial|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TIE1 SCN1B TNKS1BP1 FNBP1L

2.14e-0418770481754e965848b718be20ee97ce072ce426938a69
ToppCellfacs-Brain_Non-Myeloid-Hippocampus-24m-Neuronal|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HIPK4 SCN1B BSN TENM2

2.14e-041877042f153b203fe79f206319603cf94d3a03ab49a05d
ToppCellkidney_cells-Hypertensive_with+without-CKD-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_cortex|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ANGPT2 TIE1 SHC1 ACVRL1

2.14e-041877045274f2b302bbf7fed30c480af4f35058d2cf61e0
ToppCellfacs-Heart-RA-3m-Endothelial-endocardial_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

UNC13B ACVR1 SLC12A7 RGS3

2.18e-041887044ddb11a90bf3baa7237bde304db44dfcc56aed52
ToppCelldroplet-Lung-3m-Endothelial-capillary_endothelial-capillary_endothelial_cell-capillary_aerocyte_endothelial_cell|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

TIE1 FNBP1L ACVRL1 SLC12A5

2.18e-04188704db0652f000d459493321b53239326706eace598c
ToppCellfacs-Heart-RA-3m-Endothelial-endothelial_cell_of_endocardium|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

UNC13B ACVR1 SLC12A7 RGS3

2.18e-04188704e47e66906922d5c69b1aafe28face0787d3fc563
ToppCellP07-Endothelial-large_vessel_endothelial_cell-endothelial_cell_of_artery|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

TIE1 TNKS1BP1 ACVRL1 RGS3

2.18e-041887045bc1537e079c7435196c163bff5f639ea392a33a
ToppCellCOVID-19-Epithelial_cells|COVID-19 / group, cell type (main and fine annotations)

UNC13B SHANK2 FNBP1L B4GALNT3

2.18e-04188704c9cdee6f8d42ee69f5fb335f25084603c511bd29
ToppCelldroplet-Heart-nan-24m-Endothelial-endocardial_endothelial_cells|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

UNC13B TIE1 ACVR1 RGS3

2.23e-041897041137583e21d874c201c20581ba1995e2bfa3de59
ToppCellfacs-Brain_Non-Myeloid-Cerebellum-24m-Neuronal-nan|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SCN1B BSN UNC80 SLC12A5

2.23e-04189704f57200c93d39c9bce1adba0a6a1c178c028dd86b
ToppCellPCW_05-06-Epithelial-Epithelial_neuroendo-epi_NE_progenitor_(7)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

UNC13B SHANK2 UCP2 TENM2

2.32e-0419170405731ece7867659c662f952812805f947032fe10
ToppCellSevere-Treg|World / Disease group and Cell class

SLC12A6 UCP2 TNFRSF18 PBXIP1

2.32e-041917040a80b8c317e8da4d4722cfd13cdabc32b58021eb
ToppCellfacs-Lung-3m-Endothelial-arterial_endothelial|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

UNC13B SLC12A7 RGS3 SLC12A5

2.32e-041917046e6b2cb390cc5cd0356924a2c36fbe5b5bd5966c
ToppCellfacs-Lung-3m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

UNC13B SLC12A7 RGS3 SLC12A5

2.32e-04191704482db995930346be69072ace2fd78fd453e97fb5
ToppCellEntopeduncular-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)|Entopeduncular / BrainAtlas - Mouse McCarroll V32

BSN TENM2 UNC80 SLC12A5

2.32e-041917045d24022cec293bc8d9e978ae99a109e660bb8f83
ToppCellChildren_(3_yrs)-Epithelial|Children_(3_yrs) / Lineage, Cell type, age group and donor

UNC13B SHANK2 FNBP1L B4GALNT3

2.32e-04191704e432c6e1ae82dddf84314ce73d2b7a991630d905
ToppCellEntopeduncular-Neuronal-Inhibitory|Entopeduncular / BrainAtlas - Mouse McCarroll V32

BSN TENM2 UNC80 SLC12A5

2.32e-0419170473dae4cdea86aec62393ad7303dc7375a6b3fc86
ToppCelldroplet-Heart-nan-18m-Endothelial-endocardial_endothelial_cells|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

UNC13B ACVR1 SLC12A7 RGS3

2.36e-041927040b9b2eaed45456d7d74ce78a64ef4a26ac2458fb
ToppCellEpithelial|World / Lineage, Cell type, age group and donor

UNC13B SHANK2 FNBP1L B4GALNT3

2.36e-04192704499e8893afea5e6d3371e0bd018f7e86a524d669
ToppCellfacs-Brain_Non-Myeloid-Cerebellum-3m-Endothelial-Endothelial_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TIE1 UCP2 FNBP1L ACVRL1

2.36e-041927049d53b42cdb537b30233cdfdc08052c8b13a1113f
ToppCellfacs-Brain_Non-Myeloid-Cerebellum-3m-Endothelial-endothelial_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TIE1 UCP2 FNBP1L ACVRL1

2.36e-04192704042391162df2e3d0027688dd14163c4c6821afe0
ToppCellAdult-Epithelial|Adult / Lineage, Cell type, age group and donor

UNC13B SHANK2 FNBP1L B4GALNT3

2.36e-04192704efb962a5fd3b9bdfd8cf8d13c435e29c8271713e
ToppCellfacs-Brain_Non-Myeloid-Cortex-3m-Endothelial-Endothelial_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

UNC13B TIE1 UCP2 ACVRL1

2.36e-041927049ae05db5bfb8b9d3935c0328e6f2d489d2b1ebfd
ToppCellfacs-Brain_Non-Myeloid-Cerebellum-3m-Endothelial|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TIE1 UCP2 FNBP1L ACVRL1

2.36e-0419270471b0bfee0461ff64cef35881db3959c517e9731b
ToppCellfacs-Brain_Non-Myeloid-Cortex-3m-Endothelial|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

UNC13B TIE1 UCP2 ACVRL1

2.36e-04192704a116db7dec495e5a0ba9c7537057cd1e567d7885
ToppCellfacs-Brain_Non-Myeloid-Cortex-3m-Endothelial-endothelial_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

UNC13B TIE1 UCP2 ACVRL1

2.36e-0419270466defad13bd8e79319741e43ddb056841710b1d7
ToppCellfacs-Brain_Non-Myeloid-Cortex-24m-Neuronal|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TENM4 BSN UNC80 SLC12A5

2.41e-04193704be28070c049e7cb68bcd54f582226eb2f5e4bc1c
ToppCellfacs-Brain_Non-Myeloid-Hippocampus-3m-Endothelial-Endothelial_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TIE1 UCP2 FNBP1L ACVRL1

2.41e-04193704e4b440d50ae7391b26924778be6d9d53e0692449
ToppCellfacs-Brain_Non-Myeloid-Hippocampus-3m-Endothelial|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TIE1 UCP2 FNBP1L ACVRL1

2.41e-04193704e523dc5751f6fdcd4fc1a62b1eecd43f6ae79da9
ToppCellSmart-start-Cell-Wel_seq-Neoplastic-Differentiated-like-MES-like-MES-like_hypoxia_independent|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

TENM4 SHC1 C1S PBXIP1

2.41e-04193704a313541cedfcff8fb311b9bc60157359aa103830
ToppCellfacs-Brain_Non-Myeloid-Hippocampus-3m-Endothelial-endothelial_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TIE1 UCP2 FNBP1L ACVRL1

2.41e-041937041772f2ac217727de63c4a9303881b3a19a6bb0f0
ToppCellfacs-Brain_Non-Myeloid-Cortex-24m-Neuronal-nan|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TENM4 BSN UNC80 SLC12A5

2.41e-041937040c652ebe22ce5d2927599dd97ef1920547858395
ToppCellfacs-Brain_Non-Myeloid-Cortex-24m-Neuronal-neuron|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TENM4 BSN UNC80 SLC12A5

2.41e-041937048689a70a33a7c3823dc647d41ac0160e7c3ae396
ToppCellfacs-Brain_Non-Myeloid-Cerebellum-24m-Neuronal|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SCN1B BSN UNC80 SLC12A5

2.41e-041937045fb7808dd971c1cc64c2bd4f8f1de646fb2d77f4
ToppCellSevere-Treg|Severe / Disease group and Cell class

SLC12A6 UCP2 TNFRSF18 PBXIP1

2.46e-041947047d232d87262ec5f505901345da5113cabf821321
ToppCellfacs-Pancreas-Endocrine-18m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TENM3 TENM2 UNC80 GAA

2.51e-04195704bd8e24dd598990204998d1dd853ba7a53dc0107e
ToppCelldroplet-Heart-4Chambers-21m-Endothelial-endocardial_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

UNC13B TIE1 ACVR1 RGS3

2.51e-04195704df644b4c3ddccd34614ece5a2378000e6bc0fa10
ToppCelllymphoid-T_cell-Regulatory_T_cell|World / Lineage, cell class and subclass

UCP2 CPNE1 TNFRSF18 PBXIP1

2.56e-0419670442a4d706382be33d552ece1d0598d073857a8d4e
ToppCellMid-temporal_gyrus_(MTG)-Neuronal|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SHANK2 TENM2 UNC80 SLC12A5

2.56e-04196704676c56b44ac29f7baecb62f49bb8597cc74c0a88
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Endothelial-Endothelial_mature-Endo_capilar-G|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

ANGPT2 TIE1 ACVR1 ACVRL1

2.56e-04196704889c9fed857f64664ca1f47fcec9fecb15ed103c
ToppCellprimary_visual_cortex-Neuronal|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

GPRASP1 SCN1B UNC80 SLC12A5

2.56e-041967048efc2b3a95f57c31be203ac781b2098d4909297f
ToppCell3'_v3-GI_small-bowel-Lymphocytic_T_CD4/8-lo|GI_small-bowel / Manually curated celltypes from each tissue

SLC12A6 TNFRSF18 FCRL4 APOBR

2.56e-04196704a54ec174461944229c98a0b48b4822a556191ccb
ToppCellfrontal_cortex-Neuronal|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

GPRASP1 SCN1B UNC80 SLC12A5

2.56e-04196704de7d10da862f98894ce47244fbc992f4a12d63bb
ToppCelldroplet-Heart-nan-18m-Endothelial-endocardial_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

UNC13B ACVR1 SLC12A7 RGS3

2.56e-04196704e386526332138e636aef2542c11316347a45689c
ToppCellmoderate-Lymphoid-Treg|Lymphoid / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

IL17RE TNFRSF18 PBXIP1 HNRNPH1

2.56e-041967049152f4a8a27ff4ee28f231c5ad00eb2edd9ea6da
ToppCell3'_v3-GI_small-bowel-Lymphocytic_T_CD4/8-lo-Trm_Tgd|GI_small-bowel / Manually curated celltypes from each tissue

SLC12A6 TNFRSF18 FCRL4 APOBR

2.56e-0419670484cab9390794fe50203834b745722bf11c208ebd
ToppCell10x_3'_v2v3-Non-neoplastic-Endothelial-Endothelial_mature-Endo_arterial-G|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

ANGPT2 TIE1 ACVRL1 RGS3

2.61e-04197704a312d9cf4ced949307eb9620be4eed926300b892
ToppCell3'-Parenchyma_lung-Endothelial-Blood_vessel_EC-capillary_endothelial_cell-EC_general_capillary-EC_general_capillary_L.2.0.2.2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ANGPT2 TIE1 ACVRL1 RGS3

2.61e-0419770415d1e0dffee8f5ba8cee37adfbfa0551a0cd5e15
ToppCell5'-Adult-Appendix-Endothelial-lymphatic_endothelial-LEC1_(ACKR4+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

GPRASP1 ANGPT2 TIE1 GAA

2.61e-04197704789c97ca9d1e28df3353140046047f11fbccc1d0
ToppCell10x_5'_v1-Non-neoplastic-Lymphoid-CD4/CD8-Reg_T-F_2|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

SLC12A6 UCP2 TNFRSF18 PBXIP1

2.61e-0419770454fb7197db3c0dc87a1114e1ab1d2bfafd564b35
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Endothelial-Endothelial_mature-Endo_arterial-A|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

ANGPT2 TIE1 ACVRL1 RGS3

2.61e-041977049244f087ba4b60fdc81d54ce91860de715b3e12c
ToppCell10x_3'_v2v3-Non-neoplastic-Endothelial-Endothelial_mature-Endo_capilar-G|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

ANGPT2 TIE1 ACVR1 HERC2

2.66e-041987040a4626b51ba8b52acbaf616f0ced850079cd7149
DrugPotassium Chloride

SLC12A6 SLC12A4 SLC12A7 SLC12A5

1.22e-096704DB00761
DrugAdenosine triphosphate

TNK2 ACVR1 ACVR1B ACVRL1

3.13e-0633704DB00171
DrugDCPIB

SLC12A6 SLC12A4 SLC12A5

4.51e-0611703CID010071166
Drug((2-n-butyl-6,7-dichloro-2-cyclopentyl-2,3-dihydro-1-oxo-1H-inden-5-yl)oxy)acetic acid

SLC12A4 SLC12A7

9.32e-062702ctd:C095651
DrugFurosemide

SLC12A6 ANGPT2 SLC12A4 TIE1 SLC12A7 SLC12A5

1.14e-05164706ctd:D005665
DrugBumetanide

SLC12A6 SLC12A4 SLC12A7

1.51e-0516703ctd:D002034
Drugendografin

ELP1 C1S

2.79e-053702CID000019039
DrugAC1N4UEG

ACVR1 ACVR1B ACVRL1

3.06e-0520703CID004184747
DrugTAAD

ACVR1 ACVR1B ACVRL1

3.56e-0521703CID000133445
Drugtranexamic acid

C1S ACVR1 ACVR1B ACVRL1

4.53e-0564704CID000005526
DrugSD-208

ACVR1 ACVR1B ACVRL1

4.72e-0523703CID010316032
Drugap1-6

ACVR1 ACVR1B ACVRL1

4.72e-0523703CID003030073
Diseaseadseverin measurement

CPNE1 C1S DNMBP

1.39e-0610683EFO_0801358
Diseaseepilepsy (implicated_via_orthology)

UNC13B SLC12A6 SLC12A4 BSN SLC12A7 SLC12A5

2.14e-06163686DOID:1826 (implicated_via_orthology)
Diseasefibrodysplasia ossificans progressiva (implicated_via_orthology)

ACVR1 ACVRL1

5.23e-062682DOID:13374 (implicated_via_orthology)
Diseasehereditary lymphedema (is_implicated_in)

ANGPT2 TIE1

1.09e-047682DOID:0050580 (is_implicated_in)
Diseasecalpastatin measurement

CPNE1 DNMBP

1.45e-048682EFO_0008065
DiseaseFebrile Convulsions

SCN1B SLC12A5

1.86e-049682C0009952
DiseaseAsthma, Occupational

TENM3 HERC2

2.33e-0410682C0264423
DiseaseFamilial thoracic aortic aneurysm and aortic dissection

PLOD3 ACVRL1 B3GAT3

2.52e-0453683C4707243
Disease3-hydroxyanthranilate 3,4-dioxygenase measurement

CPNE1 DNMBP

2.84e-0411682EFO_0021862
Diseaseneutrophil collagenase measurement

CPNE1 DNMBP

6.15e-0416682EFO_0008248
DiseaseFebrile seizure (within the age range of 3 months to 6 years)

HERC1 BSN

7.82e-0418682HP_0002373
DiseaseChild Behaviour Checklist assessment

TENM4 TENM3

7.82e-0418682EFO_0005661
Diseasesuntan

C20orf203 CPNE1 HERC2

1.76e-03103683EFO_0004279
Diseaseglucose measurement

ELP1 FNBP1L ACVR1 HERC1 BSN

1.85e-03380685EFO_0004468

Protein segments in the cluster

PeptideGeneStartEntry
GFDEEGRNISKTRGW

CATSPERZ

51

Q9NTU4
DWLRGRGGAVGGEKD

B3GAT3

166

O94766
IGGMNTKEFRDRWGG

B4GALNT3

941

Q6L9W6
EIIGKGRFGEVWRGR

ACVR1B

211

P36896
WRRRKSGVGFLGDET

FCRL4

411

Q96PJ5
LECVGKGRYGEVWRG

ACVR1

211

Q04771
EAGGGGWTIIQRRED

ANGPT2

316

O15123
ECVGKGRYGEVWRGL

ACVRL1

206

P37023
GWFEGELEGRRGIFP

DNMBP

181

Q6XZF7
LEDGWLEGSLKGRTG

DNMBP

276

Q6XZF7
WERGDKFRGVGREAL

C8orf58

46

Q8NAV2
EEPGWDFEKGLGSRI

CDAN1

471

Q8IWY9
KLGDGSFGVVRRGEW

TNK2

131

Q07912
LGGWERYTEVAKRGG

RGS3

436

P49796
VRTLGLGEEWRGGDV

PLOD3

66

O60568
LGEEWRGGDVARTVG

PLOD3

71

O60568
TFGEVAKGWRRSTGE

HIPK4

21

Q8NE63
LGRVIGELGEDGWIR

HERC2

1891

O95714
LSKDGRTVWSFGGGD

HERC1

576

Q15751
LGGGRDVIVDLWEGR

IL17RE

516

Q8NFR9
GWGKGYEREREAVER

BSN

3461

Q9UPA5
GEGWGEVGGLRLSKV

C20orf203

101

Q8NBC4
RWLILRRGDEGDGGS

CUL7

41

Q14999
DDFGESKFITVGWGR

ELP1

151

O95163
LEGELEGIRGAGTWK

GCAT

31

O75600
EGGEGFVVKVRGLPW

HNRNPH1

6

P31943
NEGGEWERVRGGVPL

EIF3C

296

Q99613
DNEGGEWERVRGGVP

EIF3CL

296

B5ME19
LGSEFVTGWTGKRGR

HECTD1

806

Q9ULT8
WLSEVEGKTGGRGDR

FNBP1L

471

Q5T0N5
GDRDSEGTWRKGPEA

EIF3A

891

Q14152
DRDDGVDYWAKRGRG

BCLAF1

851

Q9NYF8
DGDLGLISGWGRTEK

C1S

561

P09871
ALTKGGEARGELFWD

GAA

846

P10253
GEDWFLDFRVLGKGG

GRK1

186

Q15835
GAEKEWGDGIRGLSL

SLC12A6

721

Q9UHW9
GAEKEWGDGIRGLSL

SLC12A7

656

Q9Y666
FSVDRWERKEGGGGI

CPOX

176

P36551
VGGGSWAELGRTERV

CPNE1

36

Q99829
GADGRREERGRGKSW

IL17RC

76

Q8NAC3
RWRREGAEGVNGGEE

FAM126B

326

Q8IXS8
EYRGAEKEWGDGIRG

SLC12A5

656

Q9H2X9
FWGGQAETERGLSRK

KCNAB3

161

O43448
EKEGIVGSWFGAREE

GPRASP1

806

Q5JY77
EEEWEFAARGGLKGQ

SUMF2

166

Q8NBJ7
EVGGRRGWAVGAARE

TRIM41

491

Q8WV44
EEWARGEVRGRTGIF

SH3D19

606

Q5HYK7
AVFVDRAGEWKLGGL

SCYL1

146

Q96KG9
GTGGLDAFGRVWDLR

PRPF4

381

O43172
RDGREGSRLWTEGEK

TENM2

2716

Q9NT68
GAEKEWGDGIRGLSL

SLC12A4

656

Q9UP95
DRVKVLSIGEGGFWE

SHANK2

551

Q9UPX8
KSLGRGAGWLSEDED

BRPF1

1066

P55201
WEEKEFGFRGTEGRL

ACD

81

Q96AP0
VEAFESREGGPWGGR

APOBR

826

Q0VD83
DGWTRVRRKEGGEGY

TRIP10

576

Q15642
IAREEGFRGLWKGTS

UCP2

166

P55851
REGEGSDKWVSRGRG

THRAP3

886

Q9Y2W1
VEVGSKDGWAFGVAR

TRIM7

401

Q9C029
GEDRRGIEKGGWQTT

UNC80

501

Q8N2C7
GGQEDREPAGRWKEG

PBXIP1

506

Q96AQ6
SREGSGRGVFKPWEE

PITHD1

46

Q9GZP4
VGDGFLLRLWDGTRG

TIE1

576

P35590
EGWLEGVNSRGDRGL

SNX18

36

Q96RF0
FEGRVVWNGSRGTKD

SCN1B

86

Q07699
VSLGDWEFGKRDSLG

TNKS1BP1

881

Q9C0C2
LEDGEMGKRGWVGEF

TNKS1BP1

1076

Q9C0C2
REGEEGLRAWTEGEK

TENM4

2711

Q6N022
RDGEEGARLWTEGEK

TENM3

2641

Q9P273
GGVRIPEARGDDAWK

UNC13B

761

O14795
GERSAEEKGRLGDLW

TNFRSF18

226

Q9Y5U5
GSAGLGGVFKVEWIR

YTHDC2

1361

Q9H6S0
RTRVEGGQLGGEEWT

SHC1

121

P29353
SSGEEYRGEWKEGRR

MORN4

11

Q8NDC4