Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	benzodiazepine receptor binding	RIMBP3 RIMBP3C RIMBP3B	3.28e-07	5	65	3	GO:0030156
GeneOntologyCellularComponent	manchette	RIMBP3 RIMBP3C RIMBP3B	8.49e-05	28	64	3	GO:0002177
GeneOntologyCellularComponent	spectrin	SPTBN4 SPTAN1	3.28e-04	9	64	2	GO:0008091
GeneOntologyCellularComponent	ciliary transition fiber	TCHP CEP89	4.09e-04	10	64	2	GO:0097539
Domain	DUF1088	NBEA LRBA	1.12e-05	2	63	2	IPR010508
Domain	DUF1088	NBEA LRBA	1.12e-05	2	63	2	PF06469
Domain	SH3	RIMBP3 SPTAN1 ITSN2 RIMBP3C RIMBP3B SPATA13	8.76e-05	216	63	6	SM00326
Domain	SH3	RIMBP3 SPTAN1 ITSN2 RIMBP3C RIMBP3B SPATA13	8.76e-05	216	63	6	PS50002
Domain	PH_dom-like	SPTBN4 PLEKHG4B RASAL3 ITSN2 NBEA LRBA ARAP1 SPATA13	8.86e-05	426	63	8	IPR011993
Domain	SH3_domain	RIMBP3 SPTAN1 ITSN2 RIMBP3C RIMBP3B SPATA13	9.68e-05	220	63	6	IPR001452
Domain	DUF4704	NBEA LRBA	1.11e-04	5	63	2	IPR031570
Domain	DUF4704	NBEA LRBA	1.11e-04	5	63	2	PF15787
Domain	Spectrin_repeat	SPTBN4 SPTAN1 EVPL	1.26e-04	29	63	3	IPR002017
Domain	SH3_9	RIMBP3 ITSN2 RIMBP3C RIMBP3B	1.39e-04	78	63	4	PF14604
Domain	PH_BEACH	NBEA LRBA	1.67e-04	6	63	2	PF14844
Domain	Spectrin/alpha-actinin	SPTBN4 SPTAN1 EVPL	1.69e-04	32	63	3	IPR018159
Domain	SPEC	SPTBN4 SPTAN1 EVPL	1.69e-04	32	63	3	SM00150
Domain	SH3_2	RIMBP3 ITSN2 RIMBP3C RIMBP3B	2.03e-04	86	63	4	IPR011511
Domain	SH3_2	RIMBP3 ITSN2 RIMBP3C RIMBP3B	2.03e-04	86	63	4	PF07653
Domain	DNA/RNA_helicase_DEAH_CS	DHX40 DHX38 RECQL4	2.22e-04	35	63	3	IPR002464
Domain	DEAH_ATP_HELICASE	DHX40 DHX38 RECQL4	2.84e-04	38	63	3	PS00690
Domain	PH-BEACH_dom	NBEA LRBA	3.09e-04	8	63	2	IPR023362
Domain	-	NBEA LRBA	3.09e-04	8	63	2	2.30.29.40
Domain	PH_BEACH	NBEA LRBA	3.09e-04	8	63	2	PS51783
Domain	PH	SPTBN4 PLEKHG4B RASAL3 ITSN2 ARAP1 SPATA13	3.44e-04	278	63	6	SM00233
Domain	PH_DOMAIN	SPTBN4 PLEKHG4B RASAL3 ITSN2 ARAP1 SPATA13	3.50e-04	279	63	6	PS50003
Domain	PH_domain	SPTBN4 PLEKHG4B RASAL3 ITSN2 ARAP1 SPATA13	3.57e-04	280	63	6	IPR001849
Domain	BEACH_dom	NBEA LRBA	3.97e-04	9	63	2	IPR000409
Domain	BEACH	NBEA LRBA	3.97e-04	9	63	2	PS50197
Domain	Beach	NBEA LRBA	3.97e-04	9	63	2	PF02138
Domain	-	NBEA LRBA	3.97e-04	9	63	2	1.10.1540.10
Domain	Beach	NBEA LRBA	3.97e-04	9	63	2	SM01026
Domain	Spectrin_alpha_SH3	SPTAN1 ITSN2	1.14e-03	15	63	2	IPR013315
Domain	DUF1605	DHX40 DHX38	1.47e-03	17	63	2	IPR011709
Domain	OB_NTP_bind	DHX40 DHX38	1.47e-03	17	63	2	PF07717
Domain	RhoGEF	PLEKHG4B ITSN2 SPATA13	1.57e-03	68	63	3	SM00325
Domain	HA2	DHX40 DHX38	1.65e-03	18	63	2	SM00847
Domain	HA2	DHX40 DHX38	1.65e-03	18	63	2	PF04408
Domain	Helicase-assoc_dom	DHX40 DHX38	1.65e-03	18	63	2	IPR007502
Domain	RhoGEF	PLEKHG4B ITSN2 SPATA13	1.70e-03	70	63	3	PF00621
Domain	DH_2	PLEKHG4B ITSN2 SPATA13	1.70e-03	70	63	3	PS50010
Domain	DH-domain	PLEKHG4B ITSN2 SPATA13	1.78e-03	71	63	3	IPR000219
Domain	-	PLEKHG4B ITSN2 SPATA13	1.78e-03	71	63	3	1.20.900.10
Domain	DEAD/DEAH_box_helicase_dom	DHX40 DHX38 RECQL4	1.92e-03	73	63	3	IPR011545
Domain	DEAD	DHX40 DHX38 RECQL4	1.92e-03	73	63	3	PF00270
Domain	-	SPTBN4 PLEKHG4B RASAL3 ITSN2 ARAP1 SPATA13	2.01e-03	391	63	6	2.30.29.30
Domain	Spectrin	SPTBN4 SPTAN1	2.71e-03	23	63	2	PF00435
Domain	Helicase_C	DHX40 DHX38 RECQL4	5.66e-03	107	63	3	PF00271
Domain	HELICc	DHX40 DHX38 RECQL4	5.66e-03	107	63	3	SM00490
Domain	Helicase_C	DHX40 DHX38 RECQL4	5.81e-03	108	63	3	IPR001650
Domain	HELICASE_CTER	DHX40 DHX38 RECQL4	5.96e-03	109	63	3	PS51194
Domain	HELICASE_ATP_BIND_1	DHX40 DHX38 RECQL4	5.96e-03	109	63	3	PS51192
Domain	DEXDc	DHX40 DHX38 RECQL4	5.96e-03	109	63	3	SM00487
Domain	Helicase_ATP-bd	DHX40 DHX38 RECQL4	6.11e-03	110	63	3	IPR014001
Pubmed	RIM-BP3 is a manchette-associated protein essential for spermiogenesis.	RIMBP3 RIMBP3C RIMBP3B	2.61e-08	4	66	3	19091768
Pubmed	Structure and evolution of RIM-BP genes: identification of a novel family member.	RIMBP3 RIMBP3C RIMBP3B	6.51e-08	5	66	3	17855024
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	LPIN3 INPP5E RPTOR UBE3B HECTD4 HELZ2 MUS81 LRBA WNK2 TOP3A ARAP1 SPATA13	1.01e-06	1105	66	12	35748872
Pubmed	Integrative characterization of germ cell-specific genes from mouse spermatocyte UniGene library.	RIMBP3 RIMBP3C RIMBP3B	2.34e-06	14	66	3	17662146
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	LPIN3 NOA1 DHX40 UBE3B DHX38 RECQL4 DIDO1 TOP3A CDC45	3.77e-06	650	66	9	38777146
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	PDS5B INCENP ZC3H13 SPTAN1 DHX38 HELZ2 ACIN1 DIDO1 FSCN1	3.92e-06	653	66	9	22586326
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	LPIN3 NEK1 CEP89 AASS INPP5E RPTOR SPTAN1 ENKD1 PPP1R12C SPATA13	4.95e-06	861	66	10	36931259
Pubmed	The BEACH Protein LRBA Promotes the Localization of the Heterotrimeric G-protein Golf to Olfactory Cilia.	NBEA LRBA	1.06e-05	3	66	2	28814779
Pubmed	Evolutionary Proteomics Uncovers Ancient Associations of Cilia with Signaling Pathways.	LEFTY1 ENKD1 CDC45	1.28e-05	24	66	3	29257953
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	PDS5B CACTIN RPTOR ZC3H13 SPTAN1 HELZ2 ACIN1 DIDO1 CDK11B	1.52e-05	774	66	9	15302935
Pubmed	Age-dependent ataxia and neurodegeneration caused by an αII spectrin mutation with impaired regulation of its calpain sensitivity.	SPTBN4 SPTAN1	3.53e-05	5	66	2	33790315
Pubmed	BCL8 is a novel, evolutionarily conserved human gene family encoding proteins with presumptive protein kinase A anchoring function.	NBEA LRBA	3.53e-05	5	66	2	12160729
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	PDS5B INCENP DHX40 RPTOR SPTAN1 DHX38 RECQL4 ACIN1 FSCN1 NEXN CDC45	4.46e-05	1353	66	11	29467282
Pubmed	An evolutionarily conserved nested gene pair - Mab21 and Lrba/Nbea in metazoan.	NBEA LRBA	5.29e-05	6	66	2	19482073
Pubmed	In vivo assembly of the axon initial segment in motor neurons.	SPTBN4 SPTAN1	5.29e-05	6	66	2	23728480
Pubmed	Spectrins and ankyrinB constitute a specialized paranodal cytoskeleton.	SPTBN4 SPTAN1	5.29e-05	6	66	2	16687515
Pubmed	Systematic analysis of human protein complexes identifies chromosome segregation proteins.	PDS5B INCENP DHX38 RECQL4 ITSN2 FSCN1 NEXN TOP3A ARAP1 PPP1R12C	6.12e-05	1155	66	10	20360068
Pubmed	N-Terminomics for the Identification of In Vitro Substrates and Cleavage Site Specificity of the SARS-CoV-2 Main Protease.	SPTAN1 ACIN1 DIDO1 EVPL FSCN1 NSRP1	6.35e-05	360	66	6	33111431
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	SPTBN4 RPTOR SPTAN1 HECTD4 DIDO1 NBEA FSCN1 WNK2 SPATA13	8.29e-05	963	66	9	28671696
Pubmed	Assembly of the Cdc45-Mcm2-7-GINS complex in human cells requires the Ctf4/And-1, RecQL4, and Mcm10 proteins.	RECQL4 CDC45	9.86e-05	8	66	2	19805216
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	SPTBN4 PLEKHG4B TCHP RPTOR LRRC27 HECTD4 LRBA ZHX2 NSRP1 WNK2 ARAP1	1.05e-04	1489	66	11	28611215
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	CERS2 NOA1 DHX40 DHX38 ITSN2 HELZ2 WHAMM DIDO1 ZHX2 DNAJC2 PPP1R12C	1.10e-04	1497	66	11	31527615
Pubmed	Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer.	PDS5B CACTIN INCENP DHX38 ACIN1 DIDO1 CDK11B FSCN1 CDC45	1.23e-04	1014	66	9	32416067
Pubmed	Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.	INCENP ZC3H13 SPTAN1 DHX38 HELZ2 ACIN1 DIDO1 EVPL FSCN1 DNAJC2	1.23e-04	1257	66	10	36526897
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	PDS5B ZFR2 ITSN2 ACIN1 ZHX2 SPATA13	1.24e-04	407	66	6	12693553
Pubmed	Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.	RIMBP3 TCHP DHX40 RPTOR DHX38 CDK11B TOP3A	1.25e-04	588	66	7	38580884
Pubmed	Brain proteins interacting with the tetramerization region of non-erythroid alpha spectrin.	SPTBN4 SPTAN1	1.93e-04	11	66	2	17607528
Pubmed	mTORC1/2 signaling is downregulated by amino acid-free culture of mouse preimplantation embryos and is only partially restored by amino acid readdition.	RPTOR IMPG2	1.93e-04	11	66	2	33052068
Pubmed	APRIN is a cell cycle specific BRCA2-interacting protein required for genome integrity and a predictor of outcome after chemotherapy in breast cancer.	PDS5B CDC45	1.93e-04	11	66	2	22293751
Pubmed	MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.	PDS5B ZC3H13 SPTAN1 HECTD4 HELZ2 ACIN1 DIDO1 CDK11B NSRP1	1.99e-04	1082	66	9	38697112
Pubmed	Mapping the Ku Interactome Using Proximity-Dependent Biotin Identification in Human Cells.	CACTIN DHX38 ACIN1 DIDO1 CDK11B	2.05e-04	283	66	5	30585729
Pubmed	Identification and Characterization of USP7 Targets in Cancer Cells.	DHX40 NSRP1	2.73e-04	13	66	2	30367141
Pubmed	alphaII-betaV spectrin bridges the plasma membrane and cortical lattice in the lateral wall of the auditory outer hair cells.	SPTBN4 SPTAN1	2.73e-04	13	66	2	18796539
Pubmed	A human MAP kinase interactome.	RASAL3 SPTAN1 ITSN2 EVPL ENKD1 WNK2	3.23e-04	486	66	6	20936779
Pubmed	Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study.	NEK1 MUS81 ACIN1 DIDO1 PPP1R15A	3.26e-04	313	66	5	20800603
Pubmed	ATG5 is required for B cell polarization and presentation of particulate antigens.	CACTIN DHX40 ZC3H13 ITSN2 HELZ2 NSRP1 DNAJC2	3.64e-04	701	66	7	30196744
Pubmed	MCM10 mediates RECQ4 association with MCM2-7 helicase complex during DNA replication.	RECQL4 CDC45	3.67e-04	15	66	2	19696745
Pubmed	Kinome siRNA screen identifies regulators of ciliogenesis and hedgehog signal transduction.	NEK1 CDK11B	3.67e-04	15	66	2	18827223
Pubmed	A probability-based approach for high-throughput protein phosphorylation analysis and site localization.	RPTOR ZC3H13 ACIN1 DIDO1 CDK11B NSRP1	3.87e-04	503	66	6	16964243
Pubmed	A genome-wide RNAi screen identifies multiple synthetic lethal interactions with the Ras oncogene.	NEK1 ZC3H13 UBE3B DHX38 DIDO1	4.21e-04	331	66	5	19490893
Pubmed	A Survey of Essential Genome Stability Genes Reveals That Replication Stress Mitigation Is Critical for Peri-Implantation Embryogenesis.	RECQL4 CDC45	4.74e-04	17	66	2	32548123
Pubmed	Menin and Menin-Associated Proteins Coregulate Cancer Energy Metabolism.	PDS5B DHX40 DHX38 ACIN1 DIDO1	4.82e-04	341	66	5	32971831
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	INPP5E RPTOR HECTD4 DIDO1 WNK2 ARAP1	5.05e-04	529	66	6	14621295
Pubmed	Organization of focal adhesion plaques is disrupted by action of the HIV-1 protease.	SPTBN4 SPTAN1	5.32e-04	18	66	2	12119179
Pubmed	Dynamic and coordinated expression profile of dbl-family guanine nucleotide exchange factors in the developing mouse brain.	ITSN2 SPATA13	5.32e-04	18	66	2	12799088
Pubmed	The protein network surrounding the human telomere repeat binding factors TRF1, TRF2, and POT1.	AASS DHX40 ZC3H13 SPTAN1	5.47e-04	197	66	4	20811636
Pubmed	Nsp2 has the potential to be a drug target revealed by global identification of SARS-CoV-2 Nsp2-interacting proteins.	SPTAN1 RECQL4 ARAP1	5.57e-04	84	66	3	34159380
Pubmed	Genetic mapping of 20 novel expressed sequence tags from midgestation mouse embryos suggests chromosomal clustering.	WNK2 SPATA13	5.94e-04	19	66	2	9070936
Pubmed	Recruitment of the human TREX complex to mRNA during splicing.	ZC3H13 ACIN1	6.59e-04	20	66	2	15998806
Pubmed	Large-scale mapping of human protein-protein interactions by mass spectrometry.	CERS2 PDS5B CACTIN TCHH DHX38 ACIN1 CDK11B LRBA FSCN1	6.91e-04	1284	66	9	17353931
Pubmed	BAP1 regulation of the key adaptor protein NCoR1 is critical for γ-globin gene repression.	PDS5B CACTIN ZC3H13 DHX38 ACIN1 DIDO1 CDK11B LRBA FSCN1	8.32e-04	1318	66	9	30463901
Pubmed	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.	CACTIN ZC3H13 DHX38 HELZ2 ACIN1 DIDO1 CDK11B	8.38e-04	807	66	7	22681889
Pubmed	Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	LRRC27 HELZ2 WNK2	9.80e-04	102	66	3	11214970
Pubmed	NDP52 interacts with mitochondrial RNA poly(A) polymerase to promote mitophagy.	SPTAN1 NEXN	1.03e-03	25	66	2	30309841
Pubmed	Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2.	SPTBN4 SPTAN1	1.03e-03	25	66	2	8493579
Pubmed	Tubby family proteins are adapters for ciliary trafficking of integral membrane proteins.	PRLHR INPP5E	1.03e-03	25	66	2	28154160
Pubmed	Neurobeachin, a protein implicated in membrane protein traffic and autism, is required for the formation and functioning of central synapses.	NBEA LRBA	1.21e-03	27	66	2	19723784
Pubmed	SLFN11 promotes CDT1 degradation by CUL4 in response to replicative DNA damage, while its absence leads to synthetic lethality with ATR/CHK1 inhibitors.	INCENP SPTAN1 HECTD4 HELZ2	1.32e-03	250	66	4	33536335
Pubmed	Long-term potentiation modulates synaptic phosphorylation networks and reshapes the structure of the postsynaptic interactome.	SPTBN4 SPTAN1 NBEA FSCN1	1.34e-03	251	66	4	27507650
Pubmed	Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes.	INCENP TCHP DHX40 SPTAN1 MUS81 LRBA	1.41e-03	645	66	6	25281560
Pubmed	HIV-1 Vpr degrades the HLTF DNA translocase in T cells and macrophages.	INCENP SPTAN1	1.70e-03	32	66	2	27114546
Pubmed	DNA Repair Network Analysis Reveals Shieldin as a Key Regulator of NHEJ and PARP Inhibitor Sensitivity.	DHX38 RECQL4 MUS81 ZHX2 TOP3A	1.71e-03	453	66	5	29656893
Pubmed	Systems analysis of RhoGEF and RhoGAP regulatory proteins reveals spatially organized RAC1 signalling from integrin adhesions.	PLEKHG4B NOA1 ITSN2 NBEA NSRP1 ARAP1 SPATA13	1.74e-03	916	66	7	32203420
Pubmed	GRAMD4 inhibits tumour metastasis by recruiting the E3 ligase ITCH to target TAK1 for degradation in hepatocellular carcinoma.	NOA1 ACIN1	1.80e-03	33	66	2	34841685
Interaction	YWHAH interactions	LPIN3 NEK1 CEP89 AASS INPP5E RPTOR ZC3H13 SPTAN1 DHX38 RECQL4 HECTD4 SPRYD3 LRBA ENKD1 WNK2 PPP1R12C SPATA13	3.71e-08	1102	64	17	int:YWHAH
Interaction	YWHAG interactions	LPIN3 NEK1 CEP89 AASS INPP5E RPTOR ZC3H13 SPTAN1 RECQL4 HECTD4 SPRYD3 ACIN1 CDK11B LRBA ENKD1 PPP1R12C SPATA13	2.23e-07	1248	64	17	int:YWHAG
Interaction	EZH1 interactions	CACTIN ZC3H13 DHX38 DIDO1 CDK11B NSRP1	4.65e-07	92	64	6	int:EZH1
Interaction	UQCR11 interactions	CACTIN ZC3H13 DIDO1 CDK11B NSRP1	7.03e-07	53	64	5	int:UQCR11
Interaction	YWHAQ interactions	LPIN3 NEK1 CEP89 AASS RPTOR ZC3H13 RECQL4 HECTD4 CDK11B LRBA FSCN1 ZHX2 ENKD1 PPP1R12C SPATA13	1.62e-06	1118	64	15	int:YWHAQ
Interaction	YWHAZ interactions	LPIN3 NEK1 RASAL3 CEP89 AASS INPP5E RPTOR SPTAN1 RECQL4 HECTD4 SPRYD3 CDK11B ZHX2 WNK2 PPP1R12C SPATA13	2.53e-06	1319	64	16	int:YWHAZ
Interaction	PSENEN interactions	ZC3H13 DHX38 DIDO1 CDK11B NSRP1	5.86e-06	81	64	5	int:PSENEN
Interaction	LINC02910 interactions	CACTIN ZC3H13 DIDO1 CDK11B NSRP1	1.28e-05	95	64	5	int:LINC02910
Interaction	GAGE5 interactions	CACTIN ZC3H13 DIDO1 NSRP1	2.23e-05	52	64	4	int:GAGE5
Interaction	ANKRD50 interactions	CACTIN ZC3H13 DIDO1 CDK11B NSRP1	2.39e-05	108	64	5	int:ANKRD50
Interaction	IFI6 interactions	CACTIN ZC3H13 DIDO1 NSRP1	2.60e-05	54	64	4	int:IFI6
Interaction	YWHAE interactions	LPIN3 NEK1 RASAL3 CEP89 AASS INPP5E RPTOR SPTAN1 RECQL4 CDK11B LRBA ENKD1 WNK2 SPATA13	3.14e-05	1256	64	14	int:YWHAE
Interaction	JMJD6 interactions	CACTIN DHX40 DHX38 DIDO1 CDK11B NSRP1	4.72e-05	205	64	6	int:JMJD6
Interaction	ANAPC15 interactions	ZC3H13 DHX38 DIDO1 CDK11B NSRP1	5.40e-05	128	64	5	int:ANAPC15
Interaction	IFI27L1 interactions	CACTIN ZC3H13 DIDO1 NSRP1	5.41e-05	65	64	4	int:IFI27L1
Interaction	TIMELESS interactions	CACTIN RECQL4 MUS81 TOP3A CDC45	7.46e-05	137	64	5	int:TIMELESS
Interaction	DDX23 interactions	PDS5B CACTIN DHX40 ZC3H13 DHX38 MUS81 ACIN1 NSRP1	1.34e-04	480	64	8	int:DDX23
Interaction	DHX40 interactions	CACTIN DHX40 ZC3H13 DHX38 RECQL4 NSRP1	1.38e-04	249	64	6	int:DHX40
Interaction	NUP43 interactions	PDS5B CACTIN INCENP ZC3H13 RECQL4 ACIN1 CDK11B FSCN1 ZHX2	1.51e-04	625	64	9	int:NUP43
Interaction	EHHADH interactions	ZC3H13 DIDO1 CDK11B NSRP1 PPP1R12C	1.59e-04	161	64	5	int:EHHADH
Interaction	TOP3B interactions	LPIN3 INPP5E RPTOR SPTAN1 UBE3B HECTD4 HELZ2 MUS81 ACIN1 LRBA WNK2 TOP3A ARAP1 SPATA13	1.71e-04	1470	64	14	int:TOP3B
Interaction	GAGE2E interactions	ZC3H13 DIDO1 NSRP1	2.02e-04	36	64	3	int:GAGE2E
Interaction	TMEM14B interactions	CACTIN ZC3H13 DHX38 DIDO1 CDK11B NSRP1	2.55e-04	279	64	6	int:TMEM14B
Interaction	DBR1 interactions	SPTAN1 DHX38 RECQL4	2.78e-04	40	64	3	int:DBR1
Cytoband	22q11.21	RIMBP3 RIMBP3C RIMBP3B CDC45	2.08e-05	111	66	4	22q11.21
Cytoband	12q24.11	TCHP UBE3B	1.04e-03	33	66	2	12q24.11
GeneFamily	EF-hand domain containing\|Spectrins	SPTBN4 SPTAN1	8.97e-05	7	38	2	1113
GeneFamily	WD repeat domain containing\|BEACH domain containing	NBEA LRBA	1.53e-04	9	38	2	1230
GeneFamily	DEAH-box helicases	DHX40 DHX38	5.07e-04	16	38	2	500
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	SPTBN4 PLEKHG4B ARAP1 SPATA13	8.92e-04	206	38	4	682
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	ITSN2 SPATA13	8.48e-03	66	38	2	722
GeneFamily	EF-hand domain containing	TCHH SPTAN1 ITSN2	1.08e-02	219	38	3	863
GeneFamily	Ankyrin repeat domain containing	GPANK1 ARAP1 PPP1R12C	1.42e-02	242	38	3	403
GeneFamily	WD repeat domain containing	RPTOR NBEA LRBA	1.75e-02	262	38	3	362
Disease	hair shape measurement	TCHH CYP46A1	1.47e-03	27	62	2	EFO_0007824
Disease	Polydactyly	NEK1 INPP5E UBE3B	1.94e-03	117	62	3	C0152427

Protein segments in the cluster

Peptide	Gene	Start	Entry
RERTRSEREWDRDKV	ACIN1	1156	Q9UKV3
ERRDLWRREAEARKQ	ENKD1	251	Q9H0I2
LAVRREDVNAWERRA	AASS	26	Q9UDR5
RHREEQDKARREWER	CDK11B	136	P21127
GRQVERWFRRRRNQD	CERS2	111	Q96G23
RDERRWIEKQNRATR	DNAJC2	241	Q99543
RSAAERDRWIEDLRR	RASAL3	276	Q86YV0
NFVRERTLDKRWRVR	PDS5B	391	Q9NTI5
RARDQRERSDRVWKR	NSRP1	366	Q9H0G5
GWRAERRRFAARERQ	RIMBP3B	46	A6NNM3
GWRAERRRFAARERQ	RIMBP3C	46	A6NJZ7
RQRRLEWERIRRQEL	ITSN2	456	Q9NZM3
RRKEQYIREREWNRR	NEXN	56	Q0ZGT2
WRRRDFLAEERSAQK	LPIN3	531	Q9BQK8
ARARVTVEWLRVRDD	LEFTY1	141	O75610
ERLERINRAREQGWR	NEK1	396	Q96PY6
RREEKDRAWERDLRT	GPANK1	336	O95872
EARRKQEEEARRLRW	INCENP	636	Q9NQS7
WRRRRFRGSQEDLEA	INPP5E	91	Q9NRR6
LIRLQGERDEWRRER	EVPL	1291	Q92817
RLDYWEDDLRRRRRF	LRBA	1981	P50851
FVIDRARQDIRSVWR	HECTD4	3416	Q9Y4D8
EKRQRDLDWDRRRIQ	RIBC2	306	Q9H4K1
LLFERQQWRRQRDLR	RIBC2	326	Q9H4K1
RRQRREWEARRRDIL	CDC45	171	O75419
FDIEWRDRRITLRAS	FSCN1	336	Q16658
RQVGRDWVQRRREAL	CYP46A1	251	Q9Y6A2
RAAIERRWRREQELC	CROCC2	406	H7BZ55
IWESTFRENRRIREL	CEP89	721	Q96ST8
EDRRRERERGRNWSR	DIDO1	2111	Q9BTC0
DWDRNRERSANRDRE	DIDO1	2146	Q9BTC0
RRLPVERVARERRWQ	A3GALT2	156	U3KPV4
RSRERRSDSEEERWQ	CACTIN	51	Q8WUQ7
WDQERRADRQEAPRR	HELZ2	2051	Q9BYK8
ARREVREDARRRWTN	DHX40	711	Q8IX18
RQRLRERLWEDCARA	NOA1	261	Q8NC60
PWEQLARDRSRFARR	PPP1R15A	581	O75807
EARRQRRQRRWEDIF	NRK	721	Q7Z2Y5
WAAAARAAQRRRRVE	RSAD1	11	Q9HA92
VTQSQADWDRARRRR	PRLHR	261	P49683
AAARERRREQLRQWG	PPP1R12C	16	Q9BZL4
QRREKRALQEWRERA	LRRC27	356	Q9C0I9
GWRAERRRFAARERQ	RIMBP3	46	Q9UFD9
DVRERLQAWERAFRR	RECQL4	6	O94761
LQAWERAFRRQRGRR	RECQL4	11	O94761
WEDDLRRRRRFVRNA	NBEA	2071	Q8NFP9
SPREFRERALRARWV	WHAMM	181	Q8TF30
RERALRARWVEADAR	WHAMM	186	Q8TF30
RARWVEADARLRQVI	WHAMM	191	Q8TF30
LDRRETERQWLIRRR	IMPG2	66	Q9BZV3
ESQIRKEREWRFLRN	RPTOR	981	Q8N122
KEREWRFLRNSRVRR	RPTOR	986	Q8N122
QDRRAREEFSRRWCV	ARAP1	761	Q96P48
RWLQACADERRRVQE	SPATA13	551	Q96N96
NQVALEAWRSRRDRE	TOR2A	206	Q5JU69
EAWRSRRDREEILLQ	TOR2A	211	Q5JU69
NWRRRIREIREVRAF	SPRYD3	26	Q8NCJ5
WQRRRQTVERRLREA	TMC8	66	Q8IU68
REKEVLRRERAVEWR	ZBED2	156	Q9BTP6
LRRERAVEWRERAVE	ZBED2	161	Q9BTP6
ERLEQLRRWHAERRR	ZFR2	531	Q9UPR6
LRFEIWFRRRRKSQD	PLEKHG4B	1066	Q96PX9
DISSRRNEVLDRWRR	SPTAN1	1521	Q13813
ERAASARRRWQRLEE	SPTBN4	746	Q9H254
ARRRWQRLEEAAARR	SPTBN4	751	Q9H254
EEFWERSRQRERERR	DHX38	126	Q92620
REAEWARERSARDRL	TCHP	361	Q9BT92
RWLRRPEDRAFSRAA	TOP3A	11	Q13472
REIDSWFSERRKLRD	ZHX2	571	Q9Y6X8
WFIDRARQAREERLV	UBE3B	11	Q7Z3V4
SIRDRVALIQWRRER	WNK2	531	Q9Y3S1
LEQRDRQRRDEELWR	TCHH	161	Q07283
RQRRDEELWRQRQEW	TCHH	166	Q07283
ERDREQERRRWQQRD	TCHH	1276	Q07283
RARERDKERERQRDW	ZC3H13	776	Q5T200
RERERRDTRQREWDR	ZC3H13	1311	Q5T200
WPRNRDRDRLRERER	ZC3H13	1331	Q5T200
IRARDEWDRQNARLR	TUSC1	76	Q2TAM9
TEWRDEATRSRRRTR	MUS81	26	Q96NY9