Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	Wnt receptor activity	FZD1 FZD8 FZD2	3.30e-06	17	35	3	GO:0042813
GeneOntologyMolecularFunction	Wnt-protein binding	FZD1 FZD8 FZD2	2.84e-05	34	35	3	GO:0017147
GeneOntologyMolecularFunction	7SK snRNA binding	CCNT1 CCNT2	1.07e-04	9	35	2	GO:0097322
GeneOntologyMolecularFunction	snRNA binding	CCNT1 GEMIN5 CCNT2	1.35e-04	57	35	3	GO:0017069
GeneOntologyMolecularFunction	cyclin-dependent protein serine/threonine kinase activator activity	CCNT1 CCNT2	3.53e-04	16	35	2	GO:0061575
GeneOntologyMolecularFunction	PDZ domain binding	FZD1 FZD8 FZD2	1.29e-03	123	35	3	GO:0030165
GeneOntologyBiologicalProcess	regulation of establishment of planar polarity	FZD1 PKHD1 FZD2	4.26e-06	19	35	3	GO:0090175
GeneOntologyBiologicalProcess	muscular septum morphogenesis	FZD1 FZD2	4.18e-05	6	35	2	GO:0003150
GeneOntologyBiologicalProcess	establishment of planar polarity	FZD1 PKHD1 FZD2	5.65e-05	44	35	3	GO:0001736
GeneOntologyBiologicalProcess	establishment of tissue polarity	FZD1 PKHD1 FZD2	6.05e-05	45	35	3	GO:0007164
GeneOntologyBiologicalProcess	membranous septum morphogenesis	FZD1 FZD2	1.25e-04	10	35	2	GO:0003149
GeneOntologyBiologicalProcess	hard palate development	FZD1 FZD2	1.25e-04	10	35	2	GO:0060022
GeneOntologyBiologicalProcess	morphogenesis of a polarized epithelium	FZD1 PKHD1 FZD2	2.57e-04	73	35	3	GO:0001738
GeneOntologyBiologicalProcess	regulation of establishment of planar polarity involved in neural tube closure	FZD1 FZD2	2.90e-04	15	35	2	GO:0090178
GeneOntologyBiologicalProcess	non-canonical Wnt signaling pathway	FZD1 FZD8 FZD2	3.00e-04	77	35	3	GO:0035567
GeneOntologyBiologicalProcess	establishment of planar polarity involved in neural tube closure	FZD1 FZD2	3.31e-04	16	35	2	GO:0090177
GeneOntologyBiologicalProcess	establishment of planar polarity of embryonic epithelium	FZD1 FZD2	4.21e-04	18	35	2	GO:0042249
GeneOntologyCellularComponent	cyclin/CDK positive transcription elongation factor complex	CCNT1 CCNT2	9.73e-05	9	35	2	GO:0008024
GeneOntologyCellularComponent	nuclear cyclin-dependent protein kinase holoenzyme complex	CCNT1 CCNT2	4.10e-04	18	35	2	GO:0019908
GeneOntologyCellularComponent	carboxy-terminal domain protein kinase complex	CCNT1 CCNT2	7.34e-04	24	35	2	GO:0032806
Domain	Frizzled	FZD1 FZD8 FZD2	9.00e-07	11	34	3	IPR000539
Domain	Frizzled	FZD1 FZD8 FZD2	9.00e-07	11	34	3	PF01534
Domain	Frizzled	FZD1 FZD8 FZD2	9.00e-07	11	34	3	SM01330
Domain	Frizzled/SFRP	FZD1 FZD8 FZD2	3.04e-06	16	34	3	IPR015526
Domain	FRI	FZD1 FZD8 FZD2	6.15e-06	20	34	3	SM00063
Domain	-	FZD1 FZD8 FZD2	7.17e-06	21	34	3	1.10.2000.10
Domain	Frizzled_dom	FZD1 FZD8 FZD2	1.09e-05	24	34	3	IPR020067
Domain	FZ	FZD1 FZD8 FZD2	1.09e-05	24	34	3	PS50038
Domain	Fz	FZD1 FZD8 FZD2	1.09e-05	24	34	3	PF01392
Domain	Cyclin_L/T	CCNT1 CCNT2	8.95e-05	8	34	2	IPR015429
Domain	GPCR_2-like	FZD1 FZD8 FZD2	1.76e-04	60	34	3	IPR017981
Domain	GPCR_2_secretin-like	FZD1 FZD8 FZD2	1.76e-04	60	34	3	IPR000832
Domain	G_PROTEIN_RECEP_F2_4	FZD1 FZD8 FZD2	1.85e-04	61	34	3	PS50261
Domain	Ig_E-set	PKHD1 PLXNB2 KCNJ14	8.85e-04	104	34	3	IPR014756
Domain	IPT	PKHD1 PLXNB2	1.10e-03	27	34	2	SM00429
Domain	CYCLINS	CCNT1 CCNT2	1.18e-03	28	34	2	PS00292
Domain	TIG	PKHD1 PLXNB2	1.45e-03	31	34	2	PF01833
Domain	IPT	PKHD1 PLXNB2	1.54e-03	32	34	2	IPR002909
Domain	Cyclin_N	CCNT1 CCNT2	1.64e-03	33	34	2	IPR006671
Domain	Cyclin_N	CCNT1 CCNT2	1.64e-03	33	34	2	PF00134
Domain	CYCLIN	CCNT1 CCNT2	2.17e-03	38	34	2	SM00385
Domain	-	CCNT1 CCNT2	2.40e-03	40	34	2	1.10.472.10
Domain	Cyclin-like	CCNT1 CCNT2	2.77e-03	43	34	2	IPR013763
Domain	-	GEMIN5 CFAP43 WDR75 PLXNB2	3.02e-03	333	34	4	2.130.10.10
Domain	WD40/YVTN_repeat-like_dom	GEMIN5 CFAP43 WDR75 PLXNB2	3.08e-03	335	34	4	IPR015943
Domain	Quinoprotein_ADH-like_supfam	GEMIN5 WDR75	4.18e-03	53	34	2	IPR011047
Domain	zf-C3HC4	PEX10 RNF7 RBCK1	7.65e-03	223	34	3	PF00097
Domain	-	PEX10 ZFYVE26 RNF7 RBCK1	8.64e-03	449	34	4	3.30.40.10
Domain	Znf_RING/FYVE/PHD	PEX10 ZFYVE26 RNF7 RBCK1	9.32e-03	459	34	4	IPR013083
Domain	WD40	GEMIN5 CFAP43 WDR75	1.26e-02	268	34	3	SM00320
Domain	WD40_repeat	GEMIN5 CFAP43 WDR75	1.31e-02	272	34	3	IPR001680
Domain	WD_REPEATS_1	GEMIN5 CFAP43 WDR75	1.39e-02	278	34	3	PS00678
Domain	WD_REPEATS_2	GEMIN5 CFAP43 WDR75	1.40e-02	279	34	3	PS50082
Domain	WD_REPEATS_REGION	GEMIN5 CFAP43 WDR75	1.40e-02	279	34	3	PS50294
Domain	WD40_repeat_dom	GEMIN5 CFAP43 WDR75	1.66e-02	297	34	3	IPR017986
Domain	ZF_RING_2	PEX10 RNF7 RBCK1	1.67e-02	298	34	3	PS50089
Pathway	KEGG_MEDICUS_REFERENCE_WNT_SIGNALING_MODULATION_SOST_LRP4	FZD1 FZD8 FZD2	2.00e-06	14	26	3	M47834
Pathway	KEGG_MEDICUS_REFERENCE_WNT5A_ROR_SIGNALING_PATHWAY	FZD1 FZD8 FZD2	3.07e-06	16	26	3	M47823
Pathway	KEGG_MEDICUS_REFERENCE_WNT_SIGNALING_MODULATION_LGR_RSPO	FZD1 FZD8 FZD2	5.29e-06	19	26	3	M47833
Pathway	PID_WNT_SIGNALING_PATHWAY	FZD1 FZD8 FZD2	1.77e-05	28	26	3	M77
Pathway	WP_WNT_SIGNALING_IN_KIDNEY_DISEASE	FZD1 FZD8 FZD2	3.82e-05	36	26	3	M39699
Pathway	WP_WNT_SIGNALING_IN_KIDNEY_DISEASE	FZD1 FZD8 FZD2	7.02e-05	44	26	3	MM15878
Pathway	KEGG_MEDICUS_VARIANT_LRP6_OVEREXPRESSION_TO_WNT_SIGNALING_PATHWAY	FZD1 FZD8 FZD2	7.51e-05	45	26	3	M47412
Pathway	KEGG_MEDICUS_REFERENCE_WNT_SIGNALING_PATHWAY	FZD1 FZD8 FZD2	8.02e-05	46	26	3	M47409
Pathway	KEGG_BASAL_CELL_CARCINOMA	FZD1 FZD8 FZD2	1.37e-04	55	26	3	M17807
Pathway	REACTOME_ASYMMETRIC_LOCALIZATION_OF_PCP_PROTEINS	FZD1 FZD8 FZD2	1.78e-04	60	26	3	MM15150
Pathway	WP_WNT_SIGNALING	FZD1 FZD8 FZD2	1.87e-04	61	26	3	MM15893
Pathway	REACTOME_ASYMMETRIC_LOCALIZATION_OF_PCP_PROTEINS	FZD1 FZD8 FZD2	2.15e-04	64	26	3	M27396
Pathway	WP_PHYSICOCHEMICAL_FEATURES_AND_TOXICITYASSOCIATED_PATHWAYS	FZD1 FZD8 FZD2	2.36e-04	66	26	3	M39642
Pathway	WP_REGULATION_OF_WNT_BCATENIN_SIGNALING_BY_SMALL_MOLECULE_COMPOUNDS	FZD1 FZD8	4.37e-04	17	26	2	M39525
Pathway	REACTOME_PCP_CE_PATHWAY	FZD1 FZD8 FZD2	4.98e-04	85	26	3	MM15041
Pathway	WP_POLYCYSTIC_KIDNEY_DISEASE_PATHWAY	FZD1 FZD8 FZD2	4.98e-04	85	26	3	M48315
Pathway	WP_NCRNAS_INVOLVED_IN_WNT_SIGNALING_IN_HEPATOCELLULAR_CARCINOMA	FZD1 FZD8 FZD2	5.69e-04	89	26	3	M39563
Pathway	WNT_SIGNALING	FZD1 FZD8 FZD2	5.69e-04	89	26	3	M5493
Pathway	REACTOME_PCP_CE_PATHWAY	FZD1 FZD8 FZD2	6.27e-04	92	26	3	M27322
Pathway	REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS	FZD1 FZD8 FZD2	6.68e-04	94	26	3	M797
Pathway	WP_LNCRNA_IN_CANONICAL_WNT_SIGNALING_AND_COLORECTAL_CANCER	FZD1 FZD8 FZD2	7.54e-04	98	26	3	M39731
Pathway	WP_WNT_SIGNALING_PATHWAY_AND_PLURIPOTENCY	FZD1 FZD8 FZD2	8.23e-04	101	26	3	MM15829
Pathway	KEGG_MELANOGENESIS	FZD1 FZD8 FZD2	8.23e-04	101	26	3	M7761
Pathway	WP_WNT_SIGNALING_AND_PLURIPOTENCY	FZD1 FZD8 FZD2	8.23e-04	101	26	3	M39387
Pathway	REACTOME_SMAD2_SMAD3_SMAD4_HETEROTRIMER_REGULATES_TRANSCRIPTION	CCNT1 CCNT2	1.03e-03	26	26	2	MM14878
Pathway	KEGG_MEDICUS_VARIANT_MLL_AF4_FUSION_TO_TRANSCRIPTIONAL_ACTIVATION	CCNT1 CCNT2	1.03e-03	26	26	2	M47439
Pathway	WP_WNT_SIGNALING_PATHWAY	FZD1 FZD8 FZD2	1.05e-03	110	26	3	MM15977
Pathway	WP_WNT_SIGNALING_WP428	FZD1 FZD8 FZD2	1.14e-03	113	26	3	M39669
Pathway	WP_ESC_PLURIPOTENCY_PATHWAYS	FZD1 FZD8 FZD2	1.23e-03	116	26	3	MM15863
Pathway	WP_EMBRYONIC_STEM_CELL_PLURIPOTENCY_PATHWAYS	FZD1 FZD8 FZD2	1.26e-03	117	26	3	M39530
Pathway	WP_OSTEOBLAST_DIFFERENTIATION_AND_RELATED_DISEASES	FZD1 FZD8 FZD2	1.29e-03	118	26	3	M39852
Pathway	WP_GPCRS_NONODORANT	FZD1 FZD8 HTR5A FZD2	1.34e-03	266	26	4	MM15843
Pathway	REACTOME_BETA_CATENIN_INDEPENDENT_WNT_SIGNALING	FZD1 FZD8 FZD2	1.46e-03	123	26	3	MM14988
Pathway	REACTOME_DISASSEMBLY_OF_THE_DESTRUCTION_COMPLEX_AND_RECRUITMENT_OF_AXIN_TO_THE_MEMBRANE	FZD1 FZD2	1.47e-03	31	26	2	M27400
Pathway	REACTOME_DISASSEMBLY_OF_THE_DESTRUCTION_COMPLEX_AND_RECRUITMENT_OF_AXIN_TO_THE_MEMBRANE	FZD1 FZD2	1.47e-03	31	26	2	MM15154
Pathway	REACTOME_HIV_ELONGATION_ARREST_AND_RECOVERY	CCNT1 CCNT2	1.67e-03	33	26	2	M27010
Pathway	REACTOME_SMAD2_SMAD3_SMAD4_HETEROTRIMER_REGULATES_TRANSCRIPTION	CCNT1 CCNT2	1.98e-03	36	26	2	M633
Pathway	WP_MALE_INFERTILITY	PEX10 CCNT1 CCNT2	2.33e-03	145	26	3	M39856
Pathway	REACTOME_BETA_CATENIN_INDEPENDENT_WNT_SIGNALING	FZD1 FZD8 FZD2	2.38e-03	146	26	3	M27288
Pathway	REACTOME_TRANSCRIPTIONAL_ACTIVITY_OF_SMAD2_SMAD3_SMAD4_HETEROTRIMER	CCNT1 CCNT2	2.57e-03	41	26	2	MM14876
Pathway	KEGG_WNT_SIGNALING_PATHWAY	FZD1 FZD8 FZD2	2.61e-03	151	26	3	M19428
Pathway	WP_BREAST_CANCER_PATHWAY	FZD1 FZD8 FZD2	2.76e-03	154	26	3	M39739
Pathway	REACTOME_TCF_DEPENDENT_SIGNALING_IN_RESPONSE_TO_WNT	FZD1 FZD8 FZD2	2.97e-03	158	26	3	MM14791
Pathway	WP_EPITHELIAL_TO_MESENCHYMAL_TRANSITION_IN_COLORECTAL_CANCER	FZD1 FZD8 FZD2	3.13e-03	161	26	3	M39770
Pathway	REACTOME_TP53_REGULATES_TRANSCRIPTION_OF_DNA_REPAIR_GENES	CCNT1 CCNT2	3.36e-03	47	26	2	MM15328
Pathway	REACTOME_TRANSCRIPTIONAL_ACTIVITY_OF_SMAD2_SMAD3_SMAD4_HETEROTRIMER	CCNT1 CCNT2	3.95e-03	51	26	2	M665
Pathway	REACTOME_FORMATION_OF_RNA_POL_II_ELONGATION_COMPLEX	CCNT1 CCNT2	5.07e-03	58	26	2	M805
Pathway	REACTOME_FORMATION_OF_RNA_POL_II_ELONGATION_COMPLEX	CCNT1 CCNT2	5.25e-03	59	26	2	MM14504
Pathway	REACTOME_TP53_REGULATES_TRANSCRIPTION_OF_DNA_REPAIR_GENES	CCNT1 CCNT2	5.78e-03	62	26	2	M27618
Pubmed	Essential roles of mesenchyme-derived beta-catenin in mouse Müllerian duct morphogenesis.	FZD1 FZD8 FZD2	1.11e-07	10	35	3	17532316
Pubmed	Expression of Frizzled genes in developing and postnatal hair follicles.	FZD1 FZD8 FZD2	1.11e-07	10	35	3	15245425
Pubmed	Molecular determinants of WNT9b responsiveness in nephron progenitor cells.	FZD1 FZD8 FZD2	1.53e-07	11	35	3	30978219
Pubmed	Frizzled-9 impairs acetylcholine receptor clustering in skeletal muscle cells.	FZD1 FZD8 FZD2	1.53e-07	11	35	3	24860427
Pubmed	Distinct but redundant expression of the Frizzled Wnt receptor genes at signaling centers of the developing mouse brain.	FZD1 FZD8 FZD2	1.53e-07	11	35	3	17582687
Pubmed	Expression of Frizzled5, Frizzled7, and Frizzled10 during early mouse development and interactions with canonical Wnt signaling.	FZD1 FZD8 FZD2	1.53e-07	11	35	3	17576136
Pubmed	Mapping of Wnt-Frizzled interactions by multiplex CRISPR targeting of receptor gene families.	FZD1 FZD8 FZD2	6.29e-07	17	35	3	28733458
Pubmed	Regulation of angiogenesis by a non-canonical Wnt-Flt1 pathway in myeloid cells.	FZD1 FZD8 FZD2	8.95e-07	19	35	3	21623369
Pubmed	Wnt/frizzled signalling modulates the migration and differentiation of immortalized cardiac fibroblasts.	FZD1 FZD2	9.84e-07	2	35	2	20189955
Pubmed	Expression of the Wnt inhibitor Dickkopf-1 is required for the induction of neural markers in mouse embryonic stem cells differentiating in response to retinoic acid.	FZD1 FZD8 FZD2	1.42e-06	22	35	3	17064353
Pubmed	A role for Wnt/beta-catenin signaling in lens epithelial differentiation.	FZD1 FZD8 FZD2	2.11e-06	25	35	3	12812787
Pubmed	Regulation of P-TEFb elongation complex activity by CDK9 acetylation.	CCNT1 CCNT2	2.95e-06	3	35	2	17452463
Pubmed	Molecular cloning, differential expression, and chromosomal localization of human frizzled-1, frizzled-2, and frizzled-7.	FZD1 FZD2	2.95e-06	3	35	2	9813155
Pubmed	Cyclin T2 is essential for mouse embryogenesis.	CCNT1 CCNT2	2.95e-06	3	35	2	19364821
Pubmed	Role of the human and murine cyclin T proteins in regulating HIV-1 tat-activation.	CCNT1 CCNT2	2.95e-06	3	35	2	10329126
Pubmed	Analysis of the effect of natural sequence variation in Tat and in cyclin T on the formation and RNA binding properties of Tat-cyclin T complexes.	CCNT1 CCNT2	2.95e-06	3	35	2	10364329
Pubmed	Identification of multiple cyclin subunits of human P-TEFb.	CCNT1 CCNT2	2.95e-06	3	35	2	9499409
Pubmed	Frizzled proteins are colonic epithelial receptors for C. difficile toxin B.	FZD1 FZD2	2.95e-06	3	35	2	27680706
Pubmed	Interactions between Tat and TAR and human immunodeficiency virus replication are facilitated by human cyclin T1 but not cyclins T2a or T2b.	CCNT1 CCNT2	2.95e-06	3	35	2	10049833
Pubmed	The CDK9-associated cyclins T1 and T2 exert opposite effects on HIV-1 Tat activity.	CCNT1 CCNT2	2.95e-06	3	35	2	10465067
Pubmed	3D representation of Wnt and Frizzled gene expression patterns in the mouse embryo at embryonic day 11.5 (Ts19).	FZD1 FZD8 FZD2	3.35e-06	29	35	3	18364260
Pubmed	Genomic analysis of mouse retinal development.	FZD1 FZD8 SLC6A11 ZFYVE26 PLEC FZD2 KCNJ14 AGPAT3	5.60e-06	1006	35	8	15226823
Pubmed	PlexinA1 signaling directs the segregation of proprioceptive sensory axons in the developing spinal cord.	FZD1 FZD8 PLXNB2 FZD2	5.88e-06	117	35	4	17145500
Pubmed	The Cdk9 and cyclin T subunits of TAK/P-TEFb localize to splicing factor-rich nuclear speckle regions.	CCNT1 CCNT2	5.90e-06	4	35	2	11282025
Pubmed	Inhibition of Wnt/β-catenin signaling by a soluble collagen-derived frizzled domain interacting with Wnt3a and the receptors frizzled 1 and 8.	FZD1 FZD8	5.90e-06	4	35	2	22303445
Pubmed	The structure of P-TEFb (CDK9/cyclin T1), its complex with flavopiridol and regulation by phosphorylation.	CCNT1 CCNT2	5.90e-06	4	35	2	18566585
Pubmed	Transcriptional activity and substrate recognition of cyclin T2 from P-TEFb.	CCNT1 CCNT2	5.90e-06	4	35	2	15563843
Pubmed	Stably overexpressed human Frizzled-2 signals through the beta-catenin pathway and does not activate Ca2+-mobilization in Human Embryonic Kidney 293 cells.	FZD1 FZD2	5.90e-06	4	35	2	18929644
Pubmed	Developmental regulators containing the I-mfa domain interact with T cyclins and Tat and modulate transcription.	CCNT1 CCNT2	5.90e-06	4	35	2	17289077
Pubmed	Wnt/Rspondin/β-catenin signals control axonal sorting and lineage progression in Schwann cell development.	FZD1 FZD8 FZD2	6.52e-06	36	35	3	24151333
Pubmed	Canonical WNT signaling promotes mammary placode development and is essential for initiation of mammary gland morphogenesis.	FZD1 FZD8 FZD2	7.09e-06	37	35	3	15342465
Pubmed	Patterns of Wnt/Fzd/LRP gene expression during embryonic hematopoiesis.	FZD1 FZD8 FZD2	7.09e-06	37	35	3	18800919
Pubmed	Tissue-specific requirements of beta-catenin in external genitalia development.	FZD1 FZD8 FZD2	7.69e-06	38	35	3	18635608
Pubmed	Wnt11 promotes cardiomyocyte development by caspase-mediated suppression of canonical Wnt signals.	FZD1 FZD8 FZD2	7.69e-06	38	35	3	21041481
Pubmed	Specificity of Hexim1 and Hexim2 complex formation with cyclin T1/T2, importin alpha and 7SK snRNA.	CCNT1 CCNT2	9.82e-06	5	35	2	19883659
Pubmed	Stromal R-spondin orchestrates gastric epithelial stem cells and gland homeostasis.	FZD1 FZD8 FZD2	1.47e-05	47	35	3	28813421
Pubmed	Malformation of Tear Ducts Underlies the Epiphora and Precocious Eyelid Opening in Prickle 1 Mutant Mice: Genetic Implications for Tear Duct Genesis.	FZD1 FZD8 FZD2	1.47e-05	47	35	3	33141892
Pubmed	Members of the WNT signaling pathways are widely expressed in mouse ovaries, oocytes, and cleavage stage embryos.	FZD1 FZD8 FZD2	1.47e-05	47	35	3	18351675
Pubmed	Release of positive transcription elongation factor b (P-TEFb) from 7SK small nuclear ribonucleoprotein (snRNP) activates hexamethylene bisacetamide-inducible protein (HEXIM1) transcription.	CCNT1 CCNT2	1.47e-05	6	35	2	24515107
Pubmed	FZD2 regulates limb development by mediating β-catenin-dependent and -independent Wnt signaling pathways.	FZD1 FZD2	1.47e-05	6	35	2	36867021
Pubmed	7SK small nuclear RNA binds to and inhibits the activity of CDK9/cyclin T complexes.	CCNT1 CCNT2	1.47e-05	6	35	2	11713533
Pubmed	AIRE recruits P-TEFb for transcriptional elongation of target genes in medullary thymic epithelial cells.	CCNT1 CCNT2	1.47e-05	6	35	2	17938200
Pubmed	Wnt antagonist SFRP3 inhibits the differentiation of mouse hepatic progenitor cells.	FZD1 FZD8 FZD2	1.67e-05	49	35	3	19562671
Pubmed	WNT signaling affects gene expression in the ventral diencephalon and pituitary gland growth.	FZD1 FZD8 FZD2	1.77e-05	50	35	3	18351662
Pubmed	Brg1 plays an essential role in development and homeostasis of the duodenum through regulation of Notch signaling.	FZD1 FZD8 FZD2	1.77e-05	50	35	3	27510977
Pubmed	MAQ1 and 7SK RNA interact with CDK9/cyclin T complexes in a transcription-dependent manner.	CCNT1 CCNT2	2.06e-05	7	35	2	12832472
Pubmed	Autosomal dominant familial exudative vitreoretinopathy in two Japanese families with FZD4 mutations (H69Y and C181R).	FZD1 FZD8	2.06e-05	7	35	2	15370539
Pubmed	Binding of the 7SK snRNA turns the HEXIM1 protein into a P-TEFb (CDK9/cyclin T) inhibitor.	CCNT1 CCNT2	2.06e-05	7	35	2	15201869
Pubmed	Sequence requirement and subtype specificity in the high-affinity interaction between human frizzled and dishevelled proteins.	FZD1 FZD2	2.74e-05	8	35	2	19388021
Pubmed	Differential expression of the Wnt putative receptors Frizzled during mouse somitogenesis.	FZD1 FZD8	2.74e-05	8	35	2	10559494
Pubmed	Direct interaction of Frizzled-1, -2, -4, and -7 with PDZ domains of PSD-95.	FZD1 FZD2	3.53e-05	9	35	2	12067714
Pubmed	TFIID component TAF7 functionally interacts with both TFIIH and P-TEFb.	CCNT1 CCNT2	3.53e-05	9	35	2	18391197
Pubmed	A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signals.	FZD1 FZD2	3.53e-05	9	35	2	9707618
Pubmed	Frizzled 2 and frizzled 7 function redundantly in convergent extension and closure of the ventricular septum and palate: evidence for a network of interacting genes.	FZD1 FZD2	3.53e-05	9	35	2	23095888
Pubmed	Wnt proteins induce dishevelled phosphorylation via an LRP5/6- independent mechanism, irrespective of their ability to stabilize beta-catenin.	FZD1 FZD8	4.40e-05	10	35	2	15143170
Pubmed	Non-proteolytic ubiquitination of OTULIN regulates NF-κB signaling pathway.	GEMIN5 RBCK1	5.38e-05	11	35	2	31504727
Pubmed	Partial interchangeability of Fz3 and Fz6 in tissue polarity signaling for epithelial orientation and axon growth and guidance.	FZD1 FZD2	5.38e-05	11	35	2	25294940
Pubmed	Role of chromatin remodeling gene Cecr2 in neurulation and inner ear development.	FZD1 FZD2	7.62e-05	13	35	2	21246654
Pubmed	MLL-AF9 and MLL-ENL alter the dynamic association of transcriptional regulators with genes critical for leukemia.	CCNT1 CCNT2	8.89e-05	14	35	2	20854876
Pubmed	Dickkopf-1 (DKK1) reveals that fibronectin is a major target of Wnt signaling in branching morphogenesis of the mouse embryonic lung.	FZD8 FZD2	1.02e-04	15	35	2	15617677
Pubmed	Conditional mutations of beta-catenin and APC reveal roles for canonical Wnt signaling in lens differentiation.	FZD1 FZD8 FZD2	1.03e-04	90	35	3	19515997
Pubmed	The bromodomain protein Brd4 is a positive regulatory component of P-TEFb and stimulates RNA polymerase II-dependent transcription.	CCNT1 CCNT2	1.33e-04	17	35	2	16109376
Pubmed	Cooperative and independent functions of FGF and Wnt signaling during early inner ear development.	FZD1 FZD8	1.33e-04	17	35	2	26443994
Pubmed	The leukemogenic AF4-MLL fusion protein causes P-TEFb kinase activation and altered epigenetic signatures.	PCSK1 CCNT1	1.49e-04	18	35	2	21030982
Pubmed	Systematic analysis of dimeric E3-RING interactions reveals increased combinatorial complexity in human ubiquitination networks.	PEX10 RNF7 RBCK1	1.63e-04	105	35	3	22493164
Pubmed	FGF signaling regulates otic placode induction and refinement by controlling both ectodermal target genes and hindbrain Wnt8a.	FZD1 FZD8	2.04e-04	21	35	2	20171206
Pubmed	A novel functional role for MMSET in RNA processing based on the link between the REIIBP isoform and its interaction with the SMN complex.	GEMIN5 PLEC	2.04e-04	21	35	2	24923560
Pubmed	A family of secreted proteins contains homology to the cysteine-rich ligand-binding domain of frizzled receptors.	FZD8 FZD2	2.68e-04	24	35	2	9096311
Pubmed	A large family of putative transmembrane receptors homologous to the product of the Drosophila tissue polarity gene frizzled.	FZD8 FZD2	2.68e-04	24	35	2	8626800
Pubmed	Constitutive activation of canonical Wnt signaling disrupts choroid plexus epithelial fate.	FZD1 FZD2	2.68e-04	24	35	2	35110543
Pubmed	Comparative interactome analysis of α-arrestin families in human and Drosophila.	CCNT1 WDR75 PLXNB2 RBCK1	2.70e-04	313	35	4	38270169
Pubmed	Submandibular parasympathetic gangliogenesis requires sprouty-dependent Wnt signals from epithelial progenitors.	FZD1 FZD2	2.91e-04	25	35	2	25805134
Pubmed	The stomach mesenchymal transcription factor Barx1 specifies gastric epithelial identity through inhibition of transient Wnt signaling.	FZD1 FZD2	2.91e-04	25	35	2	15809042
Pubmed	Frizzled 1 and frizzled 2 genes function in palate, ventricular septum and neural tube closure: general implications for tissue fusion processes.	FZD1 FZD2	3.66e-04	28	35	2	20940229
Pubmed	Analysis of the human E2 ubiquitin conjugating enzyme protein interaction network.	PEX10 RNF7 RBCK1	4.56e-04	149	35	3	19549727
Pubmed	The RNA polymerase II elongation complex.	CCNT1 CCNT2	5.09e-04	33	35	2	12676794
Pubmed	Expression patterns of Wnts, Frizzleds, sFRPs, and misexpression in transgenic mice suggesting a role for Wnts in pancreas and foregut pattern formation.	FZD8 FZD2	6.07e-04	36	35	2	12412008
Pubmed	Integrated analysis of Wnt signalling system component gene expression.	FZD1 FZD8	6.41e-04	37	35	2	35831952
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	FZD1 GEMIN5 ZFYVE26 CFAP43 PLEC PLXNB2	7.48e-04	1105	35	6	35748872
Pubmed	Novel gene function revealed by mouse mutagenesis screens for models of age-related disease.	PCSK1 ZFYVE26	9.06e-04	44	35	2	27534441
GeneFamily	G protein-coupled receptors, Class F frizzled	FZD1 FZD8 FZD2	5.44e-07	11	28	3	286
GeneFamily	Cyclins\|P-TEFb complex	CCNT1 CCNT2	1.39e-05	4	28	2	1281
GeneFamily	Cyclins	CCNT1 CCNT2	8.53e-04	28	28	2	473
GeneFamily	WD repeat domain containing	GEMIN5 CFAP43 WDR75	7.54e-03	262	28	3	362
GeneFamily	Ring finger proteins	PEX10 RNF7 RBCK1	8.61e-03	275	28	3	58
GeneFamily	Solute carriers	SLC5A9 SLC6A11 SLC35F3	2.26e-02	395	28	3	752
Coexpression	NUYTTEN_EZH2_TARGETS_UP	FZD8 ZFYVE26 RNF7 SLC35F3 PLXNB2 ABCA13 WBP1L AGPAT3 APOL6	4.77e-06	1033	34	9	M4196
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PKHD1 CFAP43 SLC35F3 ABCA13	4.00e-06	137	35	4	0aa4e14b32da0cda677cc0ed6ae470f6ecd77bea
ToppCell	facs-Lung-24m-Endothelial-capillary_endothelial-capillary_endothelial_cell-capillary_type_1_endothelial_cell\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	PCSK1 PKHD1 SLC6A11 ABCA13	7.77e-06	162	35	4	bf886e22ff2a20353499004b53f25fb9e6574896
ToppCell	PND14-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT1-AT1_mature\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	PKHD1 CYSTM1 FZD2 ABCA13	1.23e-05	182	35	4	573771130247e869e4e58f22d4a1cb31989635cf
ToppCell	PND14-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT1\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	PKHD1 CYSTM1 FZD2 ABCA13	1.23e-05	182	35	4	6cfaa2b3b3974c13b01c943f4adb70768dcc35e4
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_2\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	PKHD1 CFAP43 SLC35F3 ABCA13	1.34e-05	186	35	4	5c4ffe4e4d5536ae9f8794277fe032c693e7dd56
ToppCell	PBMC-Control-cDC_0\|Control / Compartment, Disease Groups and Clusters	NLRP1 PLEC PLXNB2 APOL6	1.75e-05	199	35	4	ebf03979ef56e978d72db475bb635b43b9cbe402
Disease	response to alcohol	PCSK1 PKHD1 SLC6A11	8.15e-05	75	33	3	EFO_0005526
Disease	hair color	FZD1 PKHD1 PLXNB2 TMEM44	3.89e-04	311	33	4	EFO_0003924

Protein segments in the cluster

Peptide	Gene	Start	Entry
EICVWWLEDCACVSK	CFAP43	411	Q8NDM7
ACVCIHLACKWSNWE	CCNT2	196	O60583
REHVWMWLWLCVCLC	APOL6	321	Q9BWW8
IISEALACFPVVWCW	ABCA13	1811	Q86UQ4
VACVCIHLACKWSNW	CCNT1	196	O60563
WSWDVECDTCAICRV	RNF7	41	Q9UBF6
WITCCPTCDVDINTW	RAG2	416	P55895
LFCWECITAWCSSKA	PEX10	291	O60683
DWIRCTVCHTEICWV	RBCK1	461	Q9BYM8
PCISCVSNRWTCQWD	PLXNB2	626	O15031
LCLVPWVSWLACTCL	NLRP1	516	Q9C000
LWILTWSVLCCASTF	FZD2	246	Q14332
AGWCCLVLWLPACVA	PRADC1	6	Q9BSG0
CVDVRWRWMCLLFSC	KCNJ14	81	Q9UNX9
TWIGIWSVLCCASTL	FZD1	321	Q9UP38
ESWRSLCTRCCWASK	FZD8	611	Q9H461
TACWTALCCCCLWDM	CYSTM1	81	Q9H1C7
LWIACDVLCCTASIW	HTR5A	116	P47898
TLWTCAAVICMAWTL	GPR173	136	Q9NS66
LIWGIAIAACCCLWL	CYP7A1	6	P22680
CAKLVILCWVCGFLW	OR11H12	156	B2RN74
GLTVLATWCWCTDQV	SLC5A9	286	Q2M3M2
WLALSCLVCCWLKRS	PKHD1	3871	P08F94
IFWGVAVVLCVCSSW	SLC35F3	66	Q8IY50
LVMLLEWWSCTECTL	AGPAT3	61	Q9NRZ7
CCWNLLSCALEWNAK	WDR75	566	Q8IWA0
VKCWDIATLECSWTL	GEMIN5	361	Q8TEQ6
CLLAAWTICYFCIWK	SLC6A11	231	P48066
SWWPAIQCCSCLVRD	SEPTIN8	461	Q92599
VCISFGLWICASSCW	TMEM44	26	Q2T9K0
WLCGLNLFWICKTCF	TMEM168	656	Q9H0V1
WSWMLQLCCCIEAHL	PLEC	841	Q15149
PVWCDWQTLRSCCVE	ZFYVE26	1531	Q68DK2
WLVWTIIIILSCCCV	WBP1L	46	Q9NX94
WSLQCTAFVLFCAWC	PCSK1	6	P29120