Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionbenzodiazepine receptor binding

RIMBP3 RIMBP3C RIMBP3B

1.10e-065973GO:0030156
GeneOntologyMolecularFunctionN-formyl peptide receptor activity

GPR32 GPR32P1

2.31e-045972GO:0004982
GeneOntologyBiologicalProcessmulti-pass transmembrane protein insertion into ER membrane

NOMO1 NOMO2 NOMO3

8.30e-069973GO:0160063
GeneOntologyBiologicalProcessneuromuscular synaptic transmission

RIMBP3 STXBP1 RIMBP3C RIMBP3B

2.41e-0536974GO:0007274
GeneOntologyCellularComponentmulti-pass translocon complex

NOMO1 NOMO2 NOMO3

8.22e-069983GO:0160064
GeneOntologyCellularComponentER membrane insertion complex

NOMO1 NOMO2 NOMO3

3.50e-0514983GO:0072379
GeneOntologyCellularComponentsarcoplasm

SGCD FSD2 RYR1 HABP4 AKAP7

2.00e-04114985GO:0016528
GeneOntologyCellularComponentmanchette

RIMBP3 RIMBP3C RIMBP3B

3.01e-0428983GO:0002177
MousePhenoabnormal skin appearance

KRT14 KRT16 ADAMTS3 WNT7A CBFB BIRC6 RYR1 TFPI JUP CTSE PCK1

3.61e-054737411MP:0009931
MousePhenohemopericardium

ADAMTS3 CBFB JUP LATS2

1.09e-0447744MP:0005244
MousePhenoectopic manchette

RIMBP3 RIMBP3C RIMBP3B

1.30e-0419743MP:0009377
MousePhenoabnormal skin morphology

KRT14 KRT16 ADAMTS3 ADAMTS2 WNT7A FSD2 CBFB BIRC6 RYR1 ADGRL4 TFPI CDC7 JUP SEPSECS RND2 CTSE PCK1 PCM1 GP2

1.50e-0414557419MP:0002060
MousePhenodetached sperm flagellum

RIMBP3 RIMBP3C RIMBP3B

1.77e-0421743MP:0008893
MousePhenoabnormal pericardium morphology

CLUAP1 ADAMTS3 CBFB MIDEAS TFPI JUP LATS2

1.84e-04225747MP:0000288
MousePhenoheart hemorrhage

ADAMTS3 CBFB JUP LATS2

2.01e-0455744MP:0009698
DomainDUF2012

NOMO1 NOMO2 NOMO3

4.46e-074913PF09430
DomainDUF2012

NOMO1 NOMO2 NOMO3

4.46e-074913IPR019008
DomainCarb-bd-like_fold

NOMO1 NOMO2 NOMO3

6.16e-068913IPR013784
DomainCarboxyPept_regulatory_dom

NOMO1 NOMO2 NOMO3

3.09e-0513913IPR014766
Domain-

NOMO1 NOMO2 NOMO3

3.09e-05139132.60.40.1120
DomainCarboxyPept-like_regulatory

NOMO1 NOMO2 NOMO3

7.24e-0517913IPR008969
DomainPeptidase_M12B_N

ADAMTS3 ADAMTS2 ADAM28

9.01e-0439913IPR002870
DomainPep_M12B_propep

ADAMTS3 ADAMTS2 ADAM28

9.01e-0439913PF01562
DomainDISINTEGRIN_1

ADAMTS3 ADAMTS2 ADAM28

9.70e-0440913PS00427
DomainReprolysin

ADAMTS3 ADAMTS2 ADAM28

9.70e-0440913PF01421
DomainADAM_MEPRO

ADAMTS3 ADAMTS2 ADAM28

9.70e-0440913PS50215
DomainDISINTEGRIN_2

ADAMTS3 ADAMTS2 ADAM28

9.70e-0440913PS50214
DomainPeptidase_M12B

ADAMTS3 ADAMTS2 ADAM28

9.70e-0440913IPR001590
DomainDisintegrin_dom

ADAMTS3 ADAMTS2 ADAM28

1.04e-0341913IPR001762
Domain-

SIGLEC12 FSD2 NOMO1 RIMBP3 MST1R TGM2 NOMO2 RIMBP3C RIMBP3B NOMO3

1.43e-0366391102.60.40.10
DomainIg-like_fold

SIGLEC12 FSD2 NOMO1 RIMBP3 MST1R TGM2 NOMO2 RIMBP3C RIMBP3B NOMO3

2.28e-037069110IPR013783
Domain-

PITPNM2 ATP9A HDHD2

3.76e-03649133.40.50.1000
DomainPLAC

ADAMTS3 ADAMTS2

3.80e-0319912PS50900
DomainPLAC

ADAMTS3 ADAMTS2

3.80e-0319912IPR010909
DomainADAM_spacer1

ADAMTS3 ADAMTS2

5.56e-0323912IPR010294
DomainADAM_spacer1

ADAMTS3 ADAMTS2

5.56e-0323912PF05986
Pubmed

Recurrent NOMO1 Gene Deletion Is a Potential Clinical Marker in Early-Onset Colorectal Cancer and Is Involved in the Regulation of Cell Migration.

NOMO1 NOMO2 NOMO3

2.31e-083100336011023
Pubmed

Silencing of nodal modulator 1 inhibits the differentiation of P19 cells into cardiomyocytes.

NOMO1 NOMO2 NOMO3

2.31e-083100325576386
Pubmed

Establishment of a conditional Nomo1 mouse model by CRISPR/Cas9 technology.

NOMO1 NOMO2 NOMO3

9.21e-084100331833031
Pubmed

RIM-BP3 is a manchette-associated protein essential for spermiogenesis.

RIMBP3 RIMBP3C RIMBP3B

9.21e-084100319091768
Pubmed

A locus for autosomal recessive pseudoxanthoma elasticum, with penetrance of vascular symptoms in carriers, maps to chromosome 16p13.1.

NOMO1 NOMO2 NOMO3

9.21e-08410039267806
Pubmed

Assembly of the U5 snRNP component PRPF8 is controlled by the HSP90/R2TP chaperones.

ATP6V1A KRT14 KRT16 CARMIL1 RANBP9 EXOSC3 PSMC2 SRPK1 MCM6 RFC2 PFKP ANKHD1 BIRC6 JUP GLG1 LPP CTNNBL1 EIF4E2

1.08e-0714151001828515276
Pubmed

Structure and evolution of RIM-BP genes: identification of a novel family member.

RIMBP3 RIMBP3C RIMBP3B

2.30e-075100317855024
Pubmed

Nicalin and its binding partner Nomo are novel Nodal signaling antagonists.

NOMO1 NOMO2 NOMO3

1.28e-068100315257293
Pubmed

Substrate-driven assembly of a translocon for multipass membrane proteins.

NOMO1 NOMO2 NOMO3

1.91e-069100336261522
Pubmed

An ER translocon for multi-pass membrane protein biogenesis.

NOMO1 NOMO2 NOMO3

3.74e-0611100332820719
Pubmed

Systematically defining selective autophagy receptor-specific cargo using autophagosome content profiling.

ATP6V1A EARS2 EXOSC3 POLRMT PSMC2 SRPK1 RFC2 PFKP ANKHD1 BIRC6 JUP NOMO2 GLG1 PCM1 KPNA3

4.49e-0612971001533545068
Pubmed

KAP1 facilitates reinstatement of heterochromatin after DNA replication.

EXOSC3 POLRMT PSMC2 MCM6 RFC2 PFKP CBFB ANKHD1 BIRC6 STXBP1 CTNNBL1

5.99e-067041001129955894
Pubmed

Targeted ubiquitination and degradation of G-protein-coupled receptor kinase 5 by the DDB1-CUL4 ubiquitin ligase complex.

RANBP9 PSMC2 SRPK1 JUP KANK1 GLG1

6.23e-06156100622952844
Pubmed

Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.

RANBP9 EXOSC3 POLRMT PSMC2 SRPK1 MCM6 RFC2 PFKP ANKHD1 MIDEAS BIRC6 TGM2 JUP CTNNBL1 KPNA3

7.45e-0613531001529467282
Pubmed

The functional diversity of epidermal keratins revealed by the partial rescue of the keratin 14 null phenotype by keratin 16.

KRT14 KRT16

8.18e-062100210477769
Pubmed

cDNA cloning, expression, and assembly characteristics of mouse keratin 16.

KRT14 KRT16

8.18e-06210029822705
Pubmed

Integrative characterization of germ cell-specific genes from mouse spermatocyte UniGene library.

RIMBP3 RIMBP3C RIMBP3B

8.20e-0614100317662146
Pubmed

FBW7 suppresses ovarian cancer development by targeting the N6-methyladenosine binding protein YTHDF2.

EXOSC3 POLRMT SRPK1 MCM6 PFKP ANKHD1 JUP LPP EIF4E2 KPNA3

9.47e-066011001033658012
Pubmed

CLEC16A interacts with retromer and TRIM27, and its loss impairs endosomal trafficking and neurodevelopment.

EARS2 MCM6 PFKP NOMO1 CDC7 PARP4 COG1 NOMO2 NOMO3 KPNA3

1.02e-056061001036538041
Pubmed

Decreased Anxiety-Related Behaviour but Apparently Unperturbed NUMB Function in Ligand of NUMB Protein-X (LNX) 1/2 Double Knockout Mice.

CARMIL1 NOMO1 NOMO2 NOMO3 TECPR1

1.71e-05110100527889896
Pubmed

Severe acute respiratory syndrome coronavirus nonstructural protein 2 interacts with a host protein complex involved in mitochondrial biogenesis and intracellular signaling.

RFC2 PCM1 EIF4E2

1.82e-0518100319640993
Pubmed

The procollagen N-proteinases ADAMTS2, 3 and 14 in pathophysiology.

ADAMTS3 ADAMTS2

2.45e-053100225863161
Pubmed

Cloning genes encoding receptors related to chemoattractant receptors.

GPR32 GPR32P1

2.45e-05310029653656
Pubmed

Keratin and filaggrin expression in keratoacanthoma.

KRT14 KRT16

2.45e-053100218005116
Pubmed

Cloning and characterization of ADAMTS-14, a novel ADAMTS displaying high homology with ADAMTS-2 and ADAMTS-3.

ADAMTS3 ADAMTS2

2.45e-053100211741898
Pubmed

Induction of human ADAMTS-2 gene expression by IL-1α is mediated by a multiple crosstalk of MEK/JNK and PI3K pathways in osteoblast like cells.

ADAMTS3 ADAMTS2

2.45e-053100226232334
Pubmed

Trifunctional chemical probes for the consolidated detection and identification of enzyme activities from complex proteomes.

PFKP TGM2

2.45e-053100212438565
Pubmed

A group of type I keratin genes on human chromosome 17: characterization and expression.

KRT14 KRT16

2.45e-05310022451124
Pubmed

IL-6 upregulates a disintegrin and metalloproteinase with thrombospondin motifs 2 (ADAMTS-2) in human osteosarcoma cells mediated by JNK pathway.

ADAMTS3 ADAMTS2

2.45e-053100224752352
Pubmed

Keratin 16 expression defines a subset of epithelial cells during skin morphogenesis and the hair cycle.

KRT14 KRT16

2.45e-053100212445204
Pubmed

Interaction of tissue transglutaminase with nuclear transport protein importin-alpha3.

TGM2 KPNA3

2.45e-053100210100610
Pubmed

Onset of re-epithelialization after skin injury correlates with a reorganization of keratin filaments in wound edge keratinocytes: defining a potential role for keratin 16.

KRT14 KRT16

2.45e-05310028636216
Pubmed

Phosphorylated tau interactome in the human Alzheimer's disease brain.

RANBP9 PSMC2 PFKP SEPTIN6 STXBP1

3.17e-05125100532812023
Pubmed

mTORC2 interactome and localization determine aggressiveness of high-grade glioma cells through association with gelsolin.

KRT14 KRT16 PSMC2 MCM6 PFKP TGM2 JUP

3.43e-05312100737120454
Pubmed

Cytoplasmic Metadherin (MTDH) provides survival advantage under conditions of stress by acting as RNA-binding protein.

CYP4V2 MCM6 RYR1 STXBP1 TRAPPC12 GLG1

3.73e-05214100622199357
Pubmed

Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways.

KRT14 KRT16 PSMC2 ANKHD1 CDC7 JUP STXBP1 LPP PCM1

3.74e-05564100921565611
Pubmed

Deregulated Cdc6 inhibits DNA replication and suppresses Cdc7-mediated phosphorylation of Mcm2-7 complex.

MCM6 CDC7

4.89e-054100220421204
Pubmed

ADAMTS: a novel family of proteases with an ADAM protease domain and thrombospondin 1 repeats.

ADAMTS3 ADAMTS2

4.89e-054100210094461
Pubmed

Expression of ADAMTS-2, -3, -13, and -14 in culprit coronary lesions in patients with acute myocardial infarction or stable angina.

ADAMTS3 ADAMTS2

4.89e-054100222205175
Pubmed

ARHGAP24 represses β-catenin transactivation-induced invasiveness in hepatocellular carcinoma mainly by acting as a GTPase-independent scaffold.

KRT14 KRT16 RANBP9 ZNF571 SRPK1 MCM6 PFKP JUP

4.94e-05451100836168627
Pubmed

Keratin 1 maintains skin integrity and participates in an inflammatory network in skin through interleukin-18.

KRT14 KRT16 JUP

5.07e-0525100323132931
Pubmed

Comparative Application of BioID and TurboID for Protein-Proximity Biotinylation.

EARS2 PSMB8 POLRMT MCM6 RFC2 ANKHD1 MIDEAS PARP4

5.41e-05457100832344865
Pubmed

KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.

GABRB3 PITPNM2 ATP6V1A KRT14 KRT16 CARMIL1 PFKP ATP9A HDHD2 SEPTIN6 JUP STXBP1 PCM1 KPNA3

6.05e-0514311001437142655
Pubmed

Proteomic identification of common SCF ubiquitin ligase FBXO6-interacting glycoproteins in three kinds of cells.

ATP6V1A EMILIN2 PSMC2 PFKP VWDE NOMO1 TGM2 NOMO2 NOMO3

7.09e-05613100922268729
Pubmed

[ADAMTS family--new extracellular matrix degrading enzyme].

ADAMTS3 ADAMTS2

8.14e-055100211831030
Pubmed

Changes in keratin and filaggrin expression in the skin of chronic proliferative dermatitis (cpdm) mutant mice.

KRT14 KRT16

8.14e-05510029873228
Pubmed

Defective stratum corneum and early neonatal death in mice lacking the gene for transglutaminase 1 (keratinocyte transglutaminase).

KRT14 TGM2

8.14e-05510029448282
Pubmed

Characterization of TG2 and TG1-TG2 double knock-out mouse epidermis.

KRT14 TGM2

8.14e-055100227864691
Pubmed

Use of monospecific antisera and cRNA probes to localize the major changes in keratin expression during normal and abnormal epidermal differentiation.

KRT14 KRT16

8.14e-05510022458356
Pubmed

WDFY4 is required for cross-presentation in response to viral and tumor antigens.

ATP6V1A WDFY4 NOMO1 NOMO2 NOMO3

9.09e-05156100530409884
Pubmed

Hepatic lipase maturation: a partial proteome of interacting factors.

NOMO1 NOMO2 NOMO3

9.78e-0531100319136429
Pubmed

A Human Tyrosine Phosphatase Interactome Mapped by Proteomic Profiling.

RANBP9 POLRMT PSMC2 SRPK1 MCM6 PFKP ANKHD1 NOMO1 SEPSECS LPP PCM1

1.15e-049741001128675297
Pubmed

An FBXW7-ZEB2 axis links EMT and tumour microenvironment to promote colorectal cancer stem cells and chemoresistance.

NOMO1 NOMO2 NOMO3

1.18e-0433100330783098
Pubmed

Characterization of the interactome of the human MutL homologues MLH1, PMS1, and PMS2.

RANBP9 PSMC2 MCM6 RFC2

1.19e-0487100417148452
Pubmed

Keratin 17 modulates hair follicle cycling in a TNFalpha-dependent fashion.

KRT14 KRT16

1.22e-046100216702408
Pubmed

Regulation of procollagen amino-propeptide processing during mouse embryogenesis by specialization of homologous ADAMTS proteases: insights on collagen biosynthesis and dermatosparaxis.

ADAMTS3 ADAMTS2

1.22e-046100216556917
Pubmed

Evolutionarily conserved regulators of tau identify targets for new therapies.

ATP6V1A PSMC2 PFKP NOMO1 NOMO2 PTS GLG1 NOMO3

1.25e-04516100836610398
Pubmed

Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes.

MCM6 RFC2 CDC7

1.29e-0434100312791985
Pubmed

Complementary proteomics strategies capture an ataxin-1 interactome in Neuro-2a cells.

ATP6V1A KRT14 KRT16 PSMC2 MCM6 RFC2 PFKP STXBP1 PCM1

1.31e-04665100930457570
Pubmed

The sequence and analysis of duplication-rich human chromosome 16.

NOMO1 NOMO2 NOMO3 PCM1

1.36e-0490100415616553
Pubmed

Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q.

EARS2 NOMO1 NOMO2 NOMO3

1.48e-0492100410493829
Pubmed

Host E3 ligase HUWE1 attenuates the proapoptotic activity of the MERS-CoV accessory protein ORF3 by promoting its ubiquitin-dependent degradation.

PSMC2 MCM6 RFC2 PFKP ANKHD1 BIRC6 NOMO3 KPNA3

1.58e-04534100835032548
Pubmed

Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism.

GABRB3 FSD2 BHLHE40 SEPTIN6 RIMBP3 JUP KPNA3

1.66e-04402100724722188
Pubmed

The genetic architecture of economic and political preferences.

DCBLD1 RGS6 PCM1

1.67e-0437100322566634
Pubmed

The Deubiquitinating Enzyme USP48 Interacts with the Retinal Degeneration-Associated Proteins UNC119a and ARL3.

ATP6V1A PSMC2 PFKP NOMO1 JUP STXBP1 NOMO2 NOMO3

1.98e-04552100836293380
Pubmed

Cell-matrix interactions and cell-cell junctions during epithelial histo-morphogenesis in the developing mouse incisor.

KRT14 JUP

2.27e-048100211669375
Pubmed

Identification of trichoplein, a novel keratin filament-binding protein.

KRT14 KRT16

2.27e-048100215731013
Pubmed

Comparative analysis of the expression of cytokeratins (1, 10, 14, 16, 4), involucrin, filaggrin and e-cadherin in plane warts and epidermodysplasia verruciformis plane wart-type lesions.

KRT14 KRT16

2.27e-048100219515043
Pubmed

Essential role of phosphorylation of MCM2 by Cdc7/Dbf4 in the initiation of DNA replication in mammalian cells.

MCM6 CDC7

2.27e-048100216899510
Pubmed

Cytokeratin, vimentin and E-cadherin immunodetection in the embryonic palate in two strains of mice with different susceptibility to glucocorticoid-induced clefting.

KRT14 KRT16

2.27e-048100211321598
Pubmed

Soluble dominant-negative receptor uncovers essential roles for fibroblast growth factors in multi-organ induction and patterning.

KRT14 MST1R

2.27e-04810029501086
Pubmed

The p300/YY1/miR-500a-5p/HDAC2 signalling axis regulates cell proliferation in human colorectal cancer.

ATP6V1A KRT14 KRT16 PFKP JUP LPP

2.28e-04298100630737378
Pubmed

Faciogenital Dysplasia 5 supports cancer stem cell traits in basal-like breast cancer by enhancing EGFR stability.

KRT14 KRT16 PFKP NOMO1 NOMO3

2.34e-04191100533762435
Pubmed

HAPSTR1 localizes HUWE1 to the nucleus to limit stress signaling pathways.

ATP6V1A RANBP9 PSMC2 RFC2 ANKHD1 BIRC6 NOMO2 KPNA3

2.49e-04571100837167062
Pubmed

C9orf72 protein quality control by UBR5-mediated heterotypic ubiquitin chains.

ATP6V1A EARS2 PSMC2 MCM6 RFC2 PFKP BIRC6 NOMO1 CDC7 NOMO2 NOMO3 KPNA3

2.65e-0412571001237317656
Pubmed

A disintegrin and metalloproteinase with thrombospondin motifs 2 cleaves and inactivates Reelin in the postnatal cerebral cortex and hippocampus, but not in the cerebellum.

ADAMTS3 ADAMTS2

2.91e-049100231491533
Pubmed

Human Cdc7-related kinase complex. In vitro phosphorylation of MCM by concerted actions of Cdks and Cdc7 and that of a criticial threonine residue of Cdc7 bY Cdks.

MCM6 CDC7

2.91e-049100210846177
Pubmed

A Mass Spectrometry-Based Profiling of Interactomes of Viral DDB1- and Cullin Ubiquitin Ligase-Binding Proteins Reveals NF-κB Inhibitory Activity of the HIV-2-Encoded Vpx.

KRT14 KRT16 JUP

3.00e-0445100330619335
Pubmed

The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.

EXOSC3 POLRMT SRPK1 RFC2 PFKP ATP9A ANKHD1 NOMO1 HABP4 GLG1 CTNNBL1 TAF1L KPNA3

3.61e-0414971001331527615
Pubmed

Hair greying is associated with active hair growth.

KRT14 KRT16

3.63e-0410100221916889
Pubmed

ADAMTS: a novel family of extracellular matrix proteases.

ADAMTS3 ADAMTS2

3.63e-0410100211167130
Pubmed

Spatiotemporal expression pattern of keratins in skin of AP-2alpha-deficient mice.

KRT14 KRT16

3.63e-0410100210571739
Pubmed

Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.

GABRB3 PITPNM2 ATP6V1A RANBP9 PSMC2 BIRC6 SEPTIN6 STXBP1 GLG1 PCM1 AKAP7

4.39e-0411391001136417873
Pubmed

The Hippo pathway effector YAP is an essential regulator of ductal progenitor patterning in the mouse submandibular gland.

KRT14 LATS2

4.43e-0411100228492365
Pubmed

Irf6 is a key determinant of the keratinocyte proliferation-differentiation switch.

KRT14 JUP

4.43e-0411100217041603
Pubmed

Interaction of LATS1 with SMAC links the MST2/Hippo pathway with apoptosis in an IAP-dependent manner.

KRT16 BIRC6 JUP PTS EIF4E2

4.66e-04222100535941108
Pubmed

LCP1 preferentially binds clasped αMβ2 integrin and attenuates leukocyte adhesion under flow.

MCM6 BIRC6 NOMO1 NOMO2 NOMO3 TECPR1

4.90e-04344100630333137
Pubmed

A protein interaction landscape of breast cancer.

POLRMT SRPK1 CBFB TGM2 JUP LPP PCM1 KPNA3

4.99e-04634100834591612
Pubmed

Interaction of human minichromosome maintenance protein-binding protein with minichromosome maintenance 2-7.

MCM6 CDC7

5.30e-0412100224299456
Pubmed

Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease.

MLH3 RGS6

5.30e-041210027596406
Pubmed

Suppression of ACE2 SUMOylation protects against SARS-CoV-2 infection through TOLLIP-mediated selective autophagy.

KRT14 KRT16 PSMC2 SRPK1 MCM6 ANKHD1 JUP KPNA3

5.36e-04641100836057605
Pubmed

HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation.

ATP6V1A SRPK1 RFC2 ANKHD1 MIDEAS SEPTIN6 TFPI TGM2 HABP4 CTNNBL1 PCM1 KPNA3

5.75e-0413711001236244648
Pubmed

Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.

POLRMT PSMC2 SRPK1 MCM6 PFKP ANKHD1 BIRC6 PCM1

6.05e-04653100822586326
Pubmed

Interactions of the human MCM-BP protein with MCM complex components and Dbf4.

MCM6 CDC7

6.25e-0413100222540012
Pubmed

Anterior cleft palate due to Cbfb deficiency and its rescue by folic acid.

KRT14 CBFB

6.25e-0413100231171577
Pubmed

Assessment of splice variant-specific functions of desmocollin 1 in the skin.

KRT14 JUP

6.25e-0413100214673151
Pubmed

Defining the human deubiquitinating enzyme interaction landscape.

RANBP9 PSMC2 MCM6 RFC2 PFKP JUP ABCC12 AKAP7 EIF4E2 KPNA3

6.43e-0410051001019615732
Pubmed

ZZW-115-dependent inhibition of NUPR1 nuclear translocation sensitizes cancer cells to genotoxic agents.

ATP6V1A SRPK1 RFC2 TFPI TGM2 CTNNBL1 PCM1 KPNA3

6.49e-04660100832780723
Pubmed

CTNNB1 in mesenchyme regulates epithelial cell differentiation during Müllerian duct and postnatal uterine development.

KRT14 WNT7A

7.28e-0414100223904126
Pubmed

Defects in Stratum Corneum Desquamation Are the Predominant Effect of Impaired ABCA12 Function in a Novel Mouse Model of Harlequin Ichthyosis.

KRT14 KRT16

7.28e-0414100227551807
GeneFamilyArmadillo repeat containing|Protein phosphatase 1 regulatory subunits

ARMCX4 JUP KPNA3

3.18e-0443563409
GeneFamilyADAM metallopeptidases with thrombospondin type 1 motif

ADAMTS3 ADAMTS2

1.56e-031956250
CoexpressionMARTORIATI_MDM4_TARGETS_NEUROEPITHELIUM_UP

PFKP BHLHE40 NOMO1 NOMO2 LPP CTSE NOMO3

6.71e-06185997MM1115
ToppCell5'-GW_trimst-2-SmallIntestine-Mesenchymal-fibroblastic-Stromal_1_(ADAMDEC1+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ADAMTS2 DCBLD1 ADAM28 TFPI TGM2 PTS

5.37e-0619899609be07ebfc3e49c3858e9b74605b69cf4fc28b56
ToppCellPND03-Immune-Immune_Myeloid-DC-cDC1-cDC1_prolif|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

RFC2 BHLHE40 WDFY4 SEPTIN6 RYR1

2.58e-05156995af47a4b17342bdb3cb62d7e2d52a81168e588629
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Cortical_Thick_Ascending_Limb_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

CYP4V2 ADAMTS3 RGS6 PLIN5 GP2

2.83e-05159995c186bf05c61fac348cf41973827cced83fafd58a
ToppCellE16.5-samps-Mesenchymal-Matrix_fibroblast-_fetal-Mature_Fibroblast_1|E16.5-samps / Age Group, Lineage, Cell class and subclass

ADAMTS2 FSD2 KIAA1614 ZNF7 TGM2

3.19e-05163995f1ec2625b52664308968b01d8e0275e1e0751480
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L6_LAMP5_C1QL2|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SIGLEC12 ADAMTS2 RIMBP3 RIMBP3C RIMBP3B

4.85e-0517899539889db130216655a34796e7030ffeb372465500
ToppCell10x5'v1-week_17-19-Hematopoietic-erythroid-early_erythroid|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

ADAMTS3 VWDE TGM2 CTSE PCK1

4.98e-051799953f73f89905c061ada4e3eb921fa394d95f95c959
ToppCellPND01-Immune-Immune_Myeloid-Monocytic-Macrophage-AM-AM_prolif|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CYP4V2 EMILIN2 MCM6 PFKP CBFB

5.39e-0518299557f8b8d7b132f3ad6f2b1e79c3812fe938657d2c
ToppCellCOVID-19_Moderate-HSPC|World / disease group, cell group and cell class

ADAMTS3 VWDE TFPI SPOCK3 FAM227A

5.68e-05184995ccc93babe1fcdeb66b78e1d8414357877a7c45bd
ToppCelldroplet-Lung-21m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell-pulmonary_artery_endothelial_cell_l27|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

SGCD ARMCX4 ATP9A KANK1 ZNF518B

5.98e-05186995c116cc9f41971622264434ebe29d18e719b0ae19
ToppCellLPS-IL1RA+antiTNF-Endothelial-Endothelial-Activated_Alv_Cap|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PITPNM2 PSMB8 ADGRL4 RGS6 SPOCK3

6.13e-05187995f3397dbc23b6c2f24e2c1ba887d8f9aef3ee01a1
ToppCellLPS-antiTNF-Endothelial-Endothelial-Alv_Gen_Intermediate|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PITPNM2 ADGRL4 RGS6 SPOCK3 ZNF518B

6.29e-05188995789d1be574e693d7bdd488f3c72c6df788e47b47
ToppCellfacs-Lung-nan-3m-Endothelial-Capillary_Aerocyte_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PITPNM2 CARMIL1 DCBLD1 RGS6 TECPR1

6.44e-0518999509dd2b3d89416192e84abe302a6237b8f3fdcb6e
ToppCellIPF-Epithelial-Basal|Epithelial / Disease state, Lineage and Cell class

KRT14 KRT16 BHLHE40 KANK1 SPOCK3

6.61e-051909954f15842b424eefadbfe451875e517cf70e29607f
ToppCellLPS-IL1RA-Endothelial-Endothelial-Alv_Gen_Intermediate|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PITPNM2 JUP RGS6 SPOCK3 ZNF518B

6.61e-05190995106ea0bb7b99c697ffc5443d72343df2484250c7
ToppCellPCW_07-8.5-Endothelial-Endothelial_cycling-endo_proliferating2_(14)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

PITPNM2 PSMB8 BHLHE40 ADGRL4 RGS6

6.94e-05192995ac3d87aa301d30515c369bd7fc16f33b82173a85
ToppCellPCW_07-8.5-Endothelial-Endothelial_cycling-endo_proliferating3_(3)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

PITPNM2 PSMB8 BHLHE40 ADGRL4 RGS6

7.11e-0519399572128ece598070f8e752a0691e024e26ab364989
ToppCellFetal_29-31_weeks-Endothelial-capillary_endothelial_cell_(Cap1)-D088|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

PITPNM2 DCBLD1 ADGRL4 TGM2 RGS6

7.11e-05193995ad2df9b77999780860141be6ec366afc0172a331
ToppCell356C-Epithelial_cells-Epithelial-H_(AT1)-|356C / Donor, Lineage, Cell class and subclass (all cells)

CYP4V2 PDE4C MCM6 TFPI JUP

7.29e-051949954c40d6b50675eae52c419d69e719a9223df02ae3
ToppCell356C-Epithelial_cells-Epithelial-H_(AT1)|356C / Donor, Lineage, Cell class and subclass (all cells)

CYP4V2 PDE4C MCM6 TFPI JUP

7.29e-0519499599a90de637e3babec2131cdd9f05ea965d8a8f30
ToppCellfacs-Lung-ENDOMUCIN-18m-Endothelial-Capillary_Aerocyte_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PITPNM2 CARMIL1 DCBLD1 RGS6 STXBP1

7.47e-05195995cad21edd90bf3e2fefdf5773a59cb1a664a69ddd
ToppCellPCW_07-8.5-Endothelial-Endothelial_cycling|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

PITPNM2 PSMB8 BHLHE40 ADGRL4 RGS6

7.47e-05195995804b7c44aaaf8ba77e36f377955df261e92f5ff9
ToppCell3'-GW_trimst-1.5-SmallIntestine-Mesenchymal-fibroblastic-Stromal_1_(ADAMDEC1+)|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

DCBLD1 ADAM28 TFPI TGM2 PTS

7.65e-0519699585507488f83d8f71b3ee2ad5e5aa0b6ad6193873
ToppCelldroplet-Trachea-nan-3m-Mesenchymal-chondrocyte|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KRT16 ADAMTS3 BHLHE40 TGM2 KANK1

7.84e-051979958786125b669d5d0b15e12df0ade6b319f09f7333
ToppCellTCGA-Pancreas-Primary_Tumor-Pancreatic_Adenocarcinoma-Ductal_Adenocarcinoma|TCGA-Pancreas / Sample_Type by Project: Shred V9

KRT16 BHLHE40 TFPI TGM2 CTSE

7.84e-05197995d8355f07a53e771052f9ab6b38814365dfe8d9ae
ToppCellTCGA-Skin-Metastatic-Melanoma|TCGA-Skin / Sample_Type by Project: Shred V9

SEPTIN6 ADGRL4 TFPI TGM2 PCM1

8.03e-05198995af4fb9eb2295c7b90624b38ba25619aa15254efa
ToppCellTCGA-Skin-Metastatic|TCGA-Skin / Sample_Type by Project: Shred V9

SEPTIN6 ADGRL4 TFPI TGM2 PCM1

8.03e-05198995ad39cce004867f083f8da1954e0cf5a263815184
ToppCellTCGA-Skin-Metastatic-Melanoma-Skin_Cutaneous_Melanoma|TCGA-Skin / Sample_Type by Project: Shred V9

SEPTIN6 ADGRL4 TFPI TGM2 PCM1

8.03e-0519899562cbf4b29e8af4983fb47a17f96da62682a5137e
ToppCelldroplet-Trachea-3m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell-smooth_muscle_cell_of_trachea_l34|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

KRT16 ADAMTS3 BHLHE40 TGM2 KANK1

8.03e-051989953575620db5aeaeb0bdcd7a8ff65c43abd3fa13e4
ToppCell3'-Broncho-tracheal-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal-Suprabasal_L.0.0.2.2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

KRT14 KRT16 BHLHE40 ADAM28 JUP

8.22e-05199995c88a28a73f54dc571f2ff1e4b55073f83cbead2c
ToppCellFrontal_cortex-Neuronal|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

GABRB3 ATP6V1A HECTD4 HABP4 STXBP1

8.22e-05199995f88039d862f3bfa01dc39d2de4f3f548dc5a0e61
ToppCellParenchyma_COVID-19-Epithelial-TX-Basal_1|Parenchyma_COVID-19 / Sample group, Lineage and Cell type

KRT14 WNT7A RYR1 JUP SPOCK3

8.41e-05200995592c7c3ded409a9957cbcdc62fcc213fa8eae598
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW16-Neuronal-Intermediate|GW16 / Sample Type, Dataset, Time_group, and Cell type.

CYP4V2 POLRMT MCM6 NOMO1 HABP4

8.41e-05200995a3fcd901cb281920f1bafdfd676399a6dc37355e
ToppCellLung_Parenchyma-Severe-Epithelial-Epithelial-Basal_1-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

KRT14 WNT7A RYR1 JUP SPOCK3

8.41e-052009958cfbde43c5e66269ad128aa5398b1517667d7d36
ToppCellLung_Parenchyma-Severe-Epithelial-Epithelial-Basal_1|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)

KRT14 WNT7A RYR1 JUP SPOCK3

8.41e-0520099561811380d9252f12f27b7ad4752380b52692677f
DiseaseSchizophrenia

GABRB3 ADAMTS3 RANBP9 CSMD2 BHLHE40 TGM2 STXBP1 PCK1 PCM1 KPNA3

4.31e-048839210C0036341
Diseaseeye morphology measurement

PFKP ATP9A TGM2 KANK1 PCM1

6.14e-04218925EFO_0007858
DiseaseCongenital pontocerebellar hypoplasia

EXOSC3 SEPSECS

7.33e-0413922C0266468
Diseasecreatinine measurement

CLUAP1 WNT7A FSD2 BIRC6 KIAA1614 RYR1 LPP PCDHGB4 PCK1 KPNA3

1.08e-039959210EFO_0004518
Diseasepancreatitis

HECTD4 STXBP1

1.12e-0316922EFO_0000278
DiseasePontoneocerebellar hypoplasia

EXOSC3 SEPSECS

1.12e-0316922cv:C1261175
Diseasealkaline phosphatase measurement

PDE4C ADAMTS2 CARMIL1 BHLHE40 VWDE KIAA1614 RGS6 ENTPD6 FAM227A PCK1

1.25e-0310159210EFO_0004533
DiseaseCleft palate

SGCD ADAM28 PCM1

1.44e-0371923HP_0000175
Diseaseinterleukin 18 measurement

BIRC6 PTS ZNF679

1.75e-0376923EFO_0004581
Diseaseairway responsiveness measurement

SGCD WDFY4

2.54e-0324922EFO_0006897
Diseaseage at menopause

PITPNM2 SRPK1 BIRC6 TFPI KPNA3

2.59e-03302925EFO_0004704

Protein segments in the cluster

PeptideGeneStartEntry
QCLVGAMVSGGGRNE

ZNF280A

146

P59817
MGFSGNGVTICEDDN

ADGRL4

46

Q9HBW9
NGVDFCDMVGNVVRA

FAM227A

151

F5H4B4
AVNERGTEEICNGGM

BIRC6

1226

Q9NR09
AQCGGTVEEMEGVIL

CSMD2

1966

Q7Z408
AEFRPEMCTEGAQQG

CTNNBL1

226

Q8WYA6
GNQLVEMGEDCDCGT

ADAM28

411

Q9UKQ2
MERPEAGGINSNECE

AKAP7

1

Q9P0M2
SGRNVETGQEMFCSG

BHLHE40

131

O14503
MNGVSEGTRGCSDRQ

GPR32

1

O75388
NEAIGGSRMGSEDQA

ARMCX4

1691

Q5H9R4
MEHDGQGNRCGDEVR

ADAMTS2

416

O95450
QGNRCGDEVRLGSIM

ADAMTS2

421

O95450
EMVNGTDSEVRCLGG

RANBP9

451

Q96S59
QGVAMEAVGQNDCSI

NOMO3

976

P69849
GERILGVGMEEQSIC

PAAT

361

Q9H8K7
CDGSEEENGRLLGQM

PCK1

46

P35558
AGGQSATCEEVRRQM

RIMBP3B

556

A6NNM3
AGGQSATCEEVRRQM

RIMBP3C

556

A6NJZ7
MAQGSGDQRAVGVAD

RGS6

1

P49758
DGGGMIAQCTVEVEV

PCDHGB4

321

Q9UN71
SLGGDGERNVQIEMA

PSMB8

56

P28062
EIQMEVDEGAGGING

MCM6

671

Q14566
QGVAMEAVGQNDCSI

NOMO2

976

Q5JPE7
DGGNEQIQMVIDSGV

KPNA3

271

O00505
EDMLVAIGGRNENGA

KLHL36

396

Q8N4N3
ELVNAGCDQEMAGRA

LATS2

106

Q9NRM7
GCDQEMAGRALKQTG

LATS2

111

Q9NRM7
RGQVGGDVNVEMDAA

KRT14

261

P02533
MIGDDCRDDVGGAQD

HDHD2

201

Q9H0R4
CRDDVGGAQDVGMLG

HDHD2

206

Q9H0R4
QELQAACGMERVLGG

KIAA1614

561

Q5VZ46
DNIQVGGTVMFCSEG

CTSE

261

P14091
AVRTEDNMGGCGVRT

HABP4

226

Q5JVS0
VGLGQTRMGFCSVQE

HMGCS2

86

P54868
NCQVSEEDGRGEPAM

PCM1

186

Q15154
MNPVEDATGDQNGIC

MLH3

1006

Q9UHC1
NVVGMVGSIDNDFCG

PFKP

166

Q01813
MENLGVGEGAEACSR

PDE4C

1

Q08493
GMGCLEFDEERAQQE

CBFB

121

Q13951
VGEGGVRMSETCVQV

GP2

96

P55259
QGVAMEAVGQNDCSI

NOMO1

976

Q15155
GNGCGVEEENFEGLM

PMS2P11

216

Q13670
GECRSVAVGAEENMN

KANK1

396

Q14678
ALRGQTGGDVNVEMD

KRT16

261

P08779
ENVVGEGTGCTAMDQ

LPP

421

Q93052
NEMNEVSGGIGDTRN

GABRB3

376

P28472
CAVGDGGNDVSMIQE

ATP9A

781

O75110
GGNDVSMIQESDCGV

ATP9A

786

O75110
GMEGGQEAVVVELQC

PARP4

161

Q9UKK3
QEGMTFNGQVCLIGD

PITPNM2

546

Q9BZ72
TCGGMVEQVQEAFGE

HECTD4

1236

Q9Y4D8
TDGVRMEEIVEGCTG

JUP

551

P14923
RGRQVSSECQGEMLD

GLG1

411

Q92896
QGNRCGDETAMGSVM

ADAMTS3

411

O15072
VCQGQGDTEDGRMTL

CEMP1

231

Q6PRD7
RLQGRGDCDMGCVVQ

FBXL19-AS1

76

Q494R0
EAADTIGQMRRCAVG

COG1

61

Q8WTW3
QCLTVAGGQDNVMGV

CDC7

106

O00311
MNGVSEGTRGCSDRQ

GPR32P1

1

Q8NGA4
MNANEDCRGDGRGSA

CYP4V2

276

Q6ZWL3
EEGMRAVSTGDCGQV

MIDEAS

431

Q6PJG2
QDGEQNGLMGRVDEG

CARMIL1

1011

Q5VZK9
CTQGVQREVSMVEGR

EMILIN2

691

Q9BXX0
AGCRDVAGDISGNMV

DCBLD1

176

Q8N8Z6
LGEQFMVGEEICGAV

EIF4E2

156

O60573
GMVNEDGTVINRQNG

RYR1

3856

P21817
MGRQDQDAGTIERCL

POLRMT

306

O00411
IDSCGRANGMGVIGQ

EXOSC3

181

Q9NQT5
EEEAGNMAAVGRLQA

CFAP74

126

Q9C0B2
MAAQVVGGTQACEGG

NUTM2D

186

Q5VT03
DDGAGGDNEVQRTML

PSMC2

286

P35998
VGDDCVSIMNGTDEG

ENTPD6

211

O75354
AGGQSATCEEVRRQM

RIMBP3

556

Q9UFD9
EKQMCQGQGRLGEED

TAF1L

1701

Q8IZX4
VVQAEMANESRGAGD

FSD2

46

A1L4K1
IGQDQTLMERDTEGG

SRPK1

336

Q96SB4
CRVEQDLAMGTDAEG

STXBP1

366

P61764
QGNRTMCEVGAVLAD

ABCC12

831

Q96J65
VGDTGMEDANAVRGS

SIGLEC12

516

Q96PQ1
MAATDIARQVGEGCR

SEPTIN6

1

Q14141
ITNCGSGFAENQMGR

EARS2

311

Q5JPH6
MGRGGCNITAIQDVT

ANKHD1

1711

Q8IWZ3
RIVGTMQGGDSDDNE

CLUAP1

351

Q96AJ1
GRVVSGMVNCNDDQG

TGM2

221

P21980
GGDIVTFDMCNGQLR

VWDE

486

Q8N2E2
MEGQSGRCKIVVVGD

RND2

1

P52198
EDGGMSSVTQEGRQA

TRAPPC12

521

Q8WVT3
GVEINAEAGNMEATC

SGCD

206

Q92629
GMNDQVWGIGCEDRA

TECPR1

341

Q7Z6L1
MGECEVQKGGCNEVN

ZNF679

131

Q8IYX0
NGVEFGCMQDGTVLG

WDFY4

2706

Q6ZS81
GCGERGNEMSEVLRD

ATP6V1A

276

P38606
MEVEAVCGGAGEVEA

RFC2

1

P35250
GGCLGNMNNFETLEE

TFPI

156

P10646
GNEVMGSRINGVADC

SPOCK3

366

Q9BQ16
VIGEGSQMGLDECQF

WNT7A

61

O00755
MDSNNFLGNCGVGER

SEPSECS

61

Q9HD40
DGDRMGVAGDICEQE

PLIN5

431

Q00G26
VCGGGMQRDKTVVEE

SMIM45

71

A0A590UK83
LGDNMECKGNLEGQE

ZNF571

86

Q7Z3V5
MSTEGGGRRCQAQVS

PTS

1

Q03393
GGESCQHEFRGDMVV

MST1R

901

Q04912
AEGMSQRCEECGKGI

ZNF7

191

P17097
CLEAGRDNGGNSERM

ZNF518B

371

Q9C0D4