Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	SNF2_N	TTF2 EP400	2.24e-03	32	41	2	PF00176
Domain	SNF2_N	TTF2 EP400	2.24e-03	32	41	2	IPR000330
Domain	DNA/RNA_helicase_DEAH_CS	TTF2 EP400	2.67e-03	35	41	2	IPR002464
Domain	DEAH_ATP_HELICASE	TTF2 EP400	3.14e-03	38	41	2	PS00690
Pubmed	Extracellular adenosine 5'-triphosphate induces a loss of CD23 from human dendritic cells via activation of P2X7 receptors.	FCER2 P2RX7	1.56e-06	2	44	2	12456589
Pubmed	Activation of the P2X7 receptor induces the rapid shedding of CD23 from human and murine B cells.	FCER2 P2RX7	4.69e-06	3	44	2	25155463
Pubmed	Transmembrane protein 168 mutation reduces cardiomyocyte cell surface expression of Nav1.5 through αB-crystallin intracellular dynamics.	TMEM168 SCN5A	9.37e-06	4	44	2	34086898
Pubmed	Identification of transmembrane protein 168 mutation in familial Brugada syndrome.	TMEM168 SCN5A	9.37e-06	4	44	2	32175648
Pubmed	Fine mapping of QT interval regions in global populations refines previously identified QT interval loci and identifies signals unique to African and Hispanic descent populations.	ATP1B1 SCN5A	9.37e-06	4	44	2	27988371
Pubmed	RNA polymerase II pausing factor NELF in CD8+ T cells promotes antitumor immunity.	NELFB PRKDC	2.34e-05	6	44	2	35444206
Pubmed	Large-scale analysis of ion channel gene expression in the mouse heart during perinatal development.	KCNQ2 CLCN4 P2RX7 SCN5A	2.93e-05	139	44	4	16985003
Pubmed	Identification of novel interaction partners for the conserved membrane proximal region of alpha-integrin cytoplasmic domains.	ITGA3 HPS5	5.60e-05	9	44	2	10094488
Pubmed	Common variants at ten loci modulate the QT interval duration in the QTSCD Study.	ATP1B1 SCN5A	8.54e-05	11	44	2	19305409
Pubmed	Massively parallel sequencing of the mouse exome to accurately identify rare, induced mutations: an immediate source for thousands of new mouse models.	PRKDC FCER2	1.21e-04	13	44	2	22724066
Pubmed	Suppression of C/EBPalpha expression in periportal hepatoblasts may stimulate biliary cell differentiation through increased Hnf6 and Hnf1b expression.	PRKDC ITGA3	1.86e-04	16	44	2	17021047
Pubmed	IL-23/IL-17A/TRPV1 axis produces mechanical pain via macrophage-sensory neuron crosstalk in female mice.	PRKDC P2RX7	3.89e-04	23	44	2	34473953
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	KCNQ2 WDR90 PRKDC ITGA3 POMGNT2 EP400 SCN5A	4.40e-04	1105	44	7	35748872
Pubmed	UBR-box containing protein, UBR5, is over-expressed in human lung adenocarcinoma and is a potential therapeutic target.	PRKDC ACADM	6.65e-04	30	44	2	32867711
Pubmed	TRIM29 regulates the assembly of DNA repair proteins into damaged chromatin.	PRKDC EP400	7.11e-04	31	44	2	26095369
Pubmed	Ion channel expression in the developing enteric nervous system.	KCNQ2 CLCN4	1.01e-03	37	44	2	25798587
GeneFamily	ADAM metallopeptidase domain containing\|CD molecules	TLR10 ITGA3 CD244 FCER2	4.39e-03	394	31	4	471
Coexpression	GSE19888_ADENOSINE_A3R_INH_PRETREAT_AND_ACT_BY_A3R_VS_TCELL_MEMBRANES_ACT_MAST_CELL_DN	NELFB GRB7 HELZ FAM185A GFER PDZRN4	8.57e-07	199	43	6	M7321
Disease	Sudden infant death syndrome	ACADM SCN5A	1.23e-04	12	41	2	C0038644
Disease	hippocampal CA4 volume	LINC02902 PDZRN4	1.49e-03	41	41	2	EFO_0009396
Disease	epilepsy (implicated_via_orthology)	ITGA3 ATP1B1 SCN5A	1.51e-03	163	41	3	DOID:1826 (implicated_via_orthology)

Protein segments in the cluster

Peptide	Gene	Start	Entry
VLGRSTLWKLRCFFF	TMCO5A	261	Q8N6Q1
FFRGLTAFTRVRWKC	EP400	1201	Q96L91
RKVCRFKLEWLGNCS	ATP1B1	146	P05026
GTLFIRCNIAWCRRR	CLCN4	346	P51793
GRCCRVLRSISRFHW	ACADM	6	P11310
VFCASCLLPWAVRRR	PDZRN4	36	Q6ZMN7
ALKGWSCCRKRTVDF	ITGB1BP2	36	Q9UKP3
GCFRLCLRQVRLWAG	FAM185A	11	Q8N0U4
RRGLWNLAARTCCLF	HPS5	366	Q9UPZ3
LLLWKCGFFKRARTR	ITGA3	1011	P26006
CCRYRGWRGRLKFAR	KCNQ2	151	O43526
AFCDRKLGAWVCDRL	FCER2	271	P06734
KFTWCLDACIRERFV	NELFB	261	Q8WX92
GRTHTDRICRFKWLC	POMGNT2	71	Q8NAT1
SIGRCRKFWERFIAL	HELZ	1056	P42694
GIACRRKFFWCYRLL	NUDT13	6	Q86X67
SGRKLWKRFFCFLRR	GRB7	241	Q14451
WACIVCVAFARKRRF	PRR27	6	Q6MZM9
FAILPSCCRWRIRKE	P2RX7	566	Q99572
WVRFLLARHSGCRAC	GLP2R	451	O95838
VVSCLKGHKRFCRWR	DMRT2	131	Q9Y5R5
LKDCKCRSRLFPRTW	IFNL3	66	Q8IZI9
CREVFRACWGSRELL	LINC02902	61	Q6ZTY9
KISSRRRQDKLWFCC	ELMO3	551	Q96BJ8
TILTTRWIFGKFFCR	GPR63	141	Q9BZJ6
KDRFRGDLRWILFCA	C19orf54	106	Q5BKX5
LRFRTCISTLCWFAF	SLC22A12	346	Q96S37
FLGTLACFCVWRRKR	CD244	241	Q9BZW8
RRKCGLFWANLRAAI	TLR10	761	Q9BXR5
RFVKRTTWDFCCGLL	SCN5A	971	Q14524
SRCCFWRRRTTKLEQ	HERC2P3	1121	Q9BVR0
KRFRAGFKRAFRWCP	TACR3	361	P29371
PFVCNWLFCGKRFTR	SP9	361	P0CG40
SRRRPCRACVDFKTW	GFER	66	P55789
WCLRRAELVFKCVKG	C12orf4	486	Q9NQ89
TLRWVKRRCTRFCSA	TP53TG5	231	Q9Y2B4
RRCWFVLKGNLLFSF	PHETA2	41	Q6ICB4
RLWDFQTGRCLCLFR	WDR90	436	Q96KV7
VRTLSRCRWKKFFCF	RHOV	221	Q96L33
WFCLLCRKAVRLFDT	TLCD3A	236	Q8TBR7
TPWFCRRCIFALAVR	PHF19	141	Q5T6S3
FARHRVCISFGLWIC	TMEM44	21	Q2T9K0
NLFWICKTCFRCLKR	TMEM168	661	Q9H0V1
RDFCGRCIREFLKWS	PRKDC	1026	P78527
RCFSLGELSCWQIKR	ZNF235	96	Q14590
FRCIRSKAEGKRWCG	TTF2	76	Q9UNY4