Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunction3-chloroallyl aldehyde dehydrogenase activity

ALDH3B1 ALDH3B2

8.16e-057402GO:0004028
GeneOntologyMolecularFunctionglyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity

ALDH3B1 ALDH3B2

1.40e-049402GO:0043878
GeneOntologyMolecularFunctionaldehyde dehydrogenase (NAD+) activity

ALDH3B1 ALDH3B2

4.04e-0415402GO:0004029
GeneOntologyMolecularFunctionaldehyde dehydrogenase [NAD(P)+] activity

ALDH3B1 ALDH3B2

5.22e-0417402GO:0004030
GeneOntologyMolecularFunctionprotein serine kinase activity

LMTK2 PRKCD PRKDC EIF2AK1 LRRK2

7.53e-04363405GO:0106310
GeneOntologyMolecularFunctioncysteine-type deubiquitinase activity

USP17L7 USP49 USP17L13

1.54e-03114403GO:0004843
GeneOntologyMolecularFunctionprotein serine/threonine kinase activity

LMTK2 PRKCD PRKDC EIF2AK1 LRRK2

1.88e-03446405GO:0004674
GeneOntologyMolecularFunctiondeubiquitinase activity

USP17L7 USP49 USP17L13

1.95e-03124403GO:0101005
GeneOntologyMolecularFunctionubiquitin-like protein peptidase activity

USP17L7 USP49 USP17L13

2.59e-03137403GO:0019783
GeneOntologyMolecularFunctionoxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

ALDH3B1 ALDH3B2

4.16e-0348402GO:0016620
GeneOntologyMolecularFunctionoxidoreductase activity, acting on the aldehyde or oxo group of donors

ALDH3B1 ALDH3B2

5.63e-0356402GO:0016903
GeneOntologyMolecularFunctionDNA-binding transcription factor activity, RNA polymerase II-specific

ZNF14 ZNF627 ZFP69B ZNF418 GPER1 ZNF268 ZNF2 ZNF575

6.16e-031412408GO:0000981
GeneOntologyMolecularFunctionprotein kinase activity

LMTK2 PRKCD PRKDC EIF2AK1 LRRK2

6.65e-03600405GO:0004672
GeneOntologyMolecularFunctioncysteine-type peptidase activity

USP17L7 USP49 USP17L13

6.66e-03192403GO:0008234
DomainAldehyde_DH_NAD(P)

ALDH3B1 ALDH3B2

2.54e-054392IPR012394
DomainKRAB

ZNF14 ZNF627 ZFP69B ZNF418 ZNF268 ZNF2

9.09e-05358396PS50805
DomainKRAB

ZNF14 ZNF627 ZFP69B ZNF418 ZNF268 ZNF2

9.09e-05358396PF01352
DomainKRAB

ZNF14 ZNF627 ZFP69B ZNF418 ZNF268 ZNF2

1.07e-04369396SM00349
DomainKRAB

ZNF14 ZNF627 ZFP69B ZNF418 ZNF268 ZNF2

1.09e-04370396IPR001909
DomainUSP_CS

USP17L7 USP49 USP17L13

3.52e-0466393IPR018200
DomainUSP_1

USP17L7 USP49 USP17L13

4.18e-0470393PS00972
DomainUCH

USP17L7 USP49 USP17L13

4.36e-0471393PF00443
DomainUSP_2

USP17L7 USP49 USP17L13

4.36e-0471393PS00973
DomainClathrin/coatomer_adapt-like_N

AP2A1 AP3D1

4.39e-0415392IPR002553
DomainAdaptin_N

AP2A1 AP3D1

4.39e-0415392PF01602
Domain-

ZNF14 ZNF627 ZFP69B ZNF418 ZNF268 ZNF2 ZNF575

4.54e-046793973.30.160.60
DomainUSP_3

USP17L7 USP49 USP17L13

4.54e-0472393PS50235
DomainUSP_dom

USP17L7 USP49 USP17L13

4.54e-0472393IPR028889
DomainPeptidase_C19_UCH

USP17L7 USP49 USP17L13

4.54e-0472393IPR001394
DomainHABP4_PAI-RBP1

USP17L7 USP17L13

5.01e-0416392PF04774
DomainAld_DH_CS_GLU

ALDH3B1 ALDH3B2

5.01e-0416392IPR029510
DomainHABP4_PAIRBP1-bd

USP17L7 USP17L13

5.01e-0416392IPR006861
Domainzf-C2H2

ZNF14 ZNF627 ZFP69B ZNF418 ZNF268 ZNF2 ZNF575

5.13e-04693397PF00096
DomainZnf_C2H2/integrase_DNA-bd

ZNF14 ZNF627 ZFP69B ZNF418 ZNF268 ZNF2 ZNF575

5.17e-04694397IPR013087
DomainAld_DH_CS_CYS

ALDH3B1 ALDH3B2

5.66e-0417392IPR016160
DomainALDEHYDE_DEHYDR_GLU

ALDH3B1 ALDH3B2

6.36e-0418392PS00687
DomainALDEHYDE_DEHYDR_CYS

ALDH3B1 ALDH3B2

6.36e-0418392PS00070
DomainARM-type_fold

NCBP1 PRKDC AP2A1 AP3D1 LRRK2

6.63e-04339395IPR016024
Domain-

ALDH3B1 ALDH3B2

7.10e-04193923.40.605.10
DomainAldedh

ALDH3B1 ALDH3B2

7.10e-0419392PF00171
DomainAldehyde_DH_dom

ALDH3B1 ALDH3B2

7.10e-0419392IPR015590
Domain-

ALDH3B1 ALDH3B2

7.10e-04193923.40.309.10
DomainAld_DH_C

ALDH3B1 ALDH3B2

7.10e-0419392IPR016163
DomainAld_DH_N

ALDH3B1 ALDH3B2

7.10e-0419392IPR016162
DomainAld_DH/histidinol_DH

ALDH3B1 ALDH3B2

7.10e-0419392IPR016161
DomainZINC_FINGER_C2H2_2

ZNF14 ZNF627 ZFP69B ZNF418 ZNF268 ZNF2 ZNF575

9.93e-04775397PS50157
DomainZINC_FINGER_C2H2_1

ZNF14 ZNF627 ZFP69B ZNF418 ZNF268 ZNF2 ZNF575

1.01e-03777397PS00028
Domain-

PRKDC AP2A1 AP3D1 LRRK2

1.15e-032223941.25.10.10
DomainZnf_C2H2-like

ZNF14 ZNF627 ZFP69B ZNF418 ZNF268 ZNF2 ZNF575

1.16e-03796397IPR015880
DomainZnf_C2H2

ZNF14 ZNF627 ZFP69B ZNF418 ZNF268 ZNF2 ZNF575

1.24e-03805397IPR007087
DomainZnF_C2H2

ZNF14 ZNF627 ZFP69B ZNF418 ZNF268 ZNF2 ZNF575

1.27e-03808397SM00355
DomainARM-like

PRKDC AP2A1 AP3D1 LRRK2

2.36e-03270394IPR011989
Domainzf-C2H2_6

ZNF14 ZNF627 ZFP69B ZNF418

4.06e-03314394PF13912
DomainKinase-like_dom

LMTK2 PRKCD PRKDC EIF2AK1 LRRK2

5.15e-03542395IPR011009
DomainProtein_kinase_ATP_BS

LMTK2 PRKCD EIF2AK1 LRRK2

7.84e-03379394IPR017441
DomainHEAT_REPEAT

PRKDC AP3D1

9.38e-0370392PS50077
DomainPROTEIN_KINASE_ATP

LMTK2 PRKCD EIF2AK1 LRRK2

1.50e-02459394PS00107
Pubmed

Dendritic cells induce Th2-mediated airway inflammatory responses to house dust mite via DNA-dependent protein kinase.

PRKCD PRKDC

1.29e-06240225692509
Pubmed

Inactivation of DNA-dependent protein kinase by protein kinase Cdelta: implications for apoptosis.

PRKCD PRKDC

1.29e-0624029774685
Pubmed

Human aldehyde dehydrogenase genes, ALDH7 and ALDH8: genomic organization and gene structure comparison.

ALDH3B1 ALDH3B2

1.29e-0624029161417
Pubmed

Mouse aldehyde dehydrogenase ALDH3B2 is localized to lipid droplets via two C-terminal tryptophan residues and lipid modification.

ALDH3B1 ALDH3B2

7.73e-06440225286108
Pubmed

A non-proteolytic role for ubiquitin in deadenylation of MHC-I mRNA by the RNA-binding E3-ligase MEX-3C.

PRKDC AP2A1 RBM19

1.81e-054440326471122
Pubmed

Identification and characterization of pancreatic eukaryotic initiation factor 2 alpha-subunit kinase, PEK, involved in translational control.

PRKCD EIF2AK1

1.93e-0564029819435
Pubmed

Calcyon, a mammalian specific NEEP21 family member, interacts with adaptor protein complex 3 (AP-3) and regulates targeting of AP-3 cargoes.

AP2A1 AP3D1

1.93e-05640222650988
Pubmed

PACS-1 binding to adaptors is required for acidic cluster motif-mediated protein traffic.

AP2A1 AP3D1

1.93e-05640211331585
Pubmed

The interferon-induced double-stranded RNA-activated protein kinase PKR will phosphorylate serine, threonine, or tyrosine at residue 51 in eukaryotic initiation factor 2alpha.

PRKCD EIF2AK1

1.93e-05640210542257
Pubmed

A synthetic peptide substrate for initiation factor-2 kinases.

PRKCD EIF2AK1

2.70e-0574021677563
Pubmed

Targeted ubiquitination and degradation of G-protein-coupled receptor kinase 5 by the DDB1-CUL4 ubiquitin ligase complex.

NCBP1 PRKDC AP2A1 AP3D1

3.14e-0515640422952844
Pubmed

Doublecortin interacts with mu subunits of clathrin adaptor complexes in the developing nervous system.

AP2A1 AP3D1

4.62e-05940211591131
Pubmed

Dependence of leucine-rich repeat kinase 2 (LRRK2) kinase activity on dimerization.

PRKDC LRRK2

5.77e-051040219826009
Pubmed

Identification of synthetic lethality of PRKDC in MYC-dependent human cancers by pooled shRNA screening.

PRKCD PRKDC

5.77e-051040225495526
Pubmed

Mutation specific functions of EGFR result in a mutation-specific downstream pathway activation.

ALDH3B1 AP2A1 DNAJC16

6.71e-056840325754235
Pubmed

Mitochondrial Stress Induces an HRI-eIF2α Pathway Protective for Cardiomyopathy.

EIF2AK1 TAFAZZIN

1.16e-041440236154620
Pubmed

APache Is an AP2-Interacting Protein Involved in Synaptic Vesicle Trafficking and Neuronal Development.

AP2A1 AP3D1

1.16e-041440229262337
Pubmed

LRRK2 controls synaptic vesicle storage and mobilization within the recycling pool.

AP2A1 LRRK2

1.34e-041540221307259
Pubmed

Identification of potential protein interactors of Lrrk2.

PRKDC LRRK2

1.34e-041540217400507
Pubmed

METTL3 protects METTL14 from STUB1-mediated degradation to maintain m6 A homeostasis.

NCBP1 PRKDC HERC1 AP2A1

1.44e-0423140436597993
Pubmed

Wrapping up the bad news: HIV assembly and release.

AP2A1 AP3D1

1.95e-041840223305486
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

LMTK2 PRKDC HERC1 AP2A1 AP3D1 RBM19 MED13

2.39e-04110540735748872
Pubmed

DUB-2A, a new member of the DUB subfamily of hematopoietic deubiquitinating enzymes.

USP17L7 USP17L13

2.67e-042140211468161
Pubmed

The murine DUB-1 gene is specifically induced by the betac subunit of interleukin-3 receptor.

USP17L7 USP17L13

2.67e-04214028756639
Pubmed

DUB-1, a deubiquitinating enzyme with growth-suppressing activity.

USP17L7 USP17L13

2.67e-04214028622927
Pubmed

DUB-1A, a novel deubiquitinating enzyme subfamily member, is polyubiquitinated and cytokine-inducible in B-lymphocytes.

USP17L7 USP17L13

2.67e-042140214583620
Pubmed

Lymphocyte-specific murine deubiquitinating enzymes induced by cytokines.

USP17L7 USP17L13

2.67e-042140212447969
Pubmed

In silico QTL mapping of basal liver iron levels in inbred mouse strains.

LMTK2 EIF2AK1

2.67e-042140221062905
Pubmed

DUB-1, a fate determinant of dynein heavy chain in B-lymphocytes, is regulated by the ubiquitin-proteasome pathway.

USP17L7 USP17L13

2.67e-042140218980247
Pubmed

JAK2 is required for induction of the murine DUB-1 gene.

USP17L7 USP17L13

2.94e-04224029154835
Pubmed

Human immunodeficiency virus type-1 gag and host vesicular trafficking pathways.

AP2A1 AP3D1

3.50e-042440220012524
Pubmed

DUB-2 is a member of a novel family of cytokine-inducible deubiquitinating enzymes.

USP17L7 USP17L13

3.50e-04244028995226
Pubmed

Human immunodeficiency virus (HIV) type-1, HIV-2 and simian immunodeficiency virus Nef proteins.

AP2A1 AP3D1

3.80e-042540220594957
Pubmed

Interleukin 1 receptor signaling regulates DUBA expression and facilitates Toll-like receptor 9-driven antiinflammatory cytokine production.

USP17L7 USP17L13

3.80e-042540221115691
Pubmed

Decabromodiphenyl ethane affects embryonic development by interfering with nuclear F-actin in zygotes and leads to cognitive and social disorders in offspring mice.

USP17L7 USP17L13

4.12e-042640235816173
Pubmed

The AP-3 complex: a coat of many colours.

AP2A1 AP3D1

4.78e-04284029714600
Pubmed

Minor Splicing Factors Zrsr1 and Zrsr2 Are Essential for Early Embryo Development and 2-Cell-Like Conversion.

USP17L7 USP17L13

5.13e-042940232527007
Pubmed

AAA+ proteins RUVBL1 and RUVBL2 coordinate PIKK activity and function in nonsense-mediated mRNA decay.

NCBP1 PRKDC

5.13e-042940220371770
Pubmed

Spindle Assembly Checkpoint Inhibition Can Resensitize p53-Null Stem Cells to Cancer Chemotherapy.

GPER1 ZNF268 FCRL6

5.31e-0413740330862715
Pubmed

Proteomic analysis of the NOS2 interactome in human airway epithelial cells.

PRKDC HERC1 ALDH3B1

5.42e-0413840323438482
Pubmed

Different evolutionary processes shaped the mouse and human olfactory receptor gene families.

OR1L6 OR5L2 OR5B2 OR4C45

6.21e-0434040411875048
Pubmed

The olfactory receptor gene superfamily of the mouse.

OR1L6 OR5L2 OR5B2 OR4C45

6.21e-0434040411802173
Pubmed

A unified nomenclature for vertebrate olfactory receptors.

OR1L6 OR5L2 OR5B2 OR4C45

6.42e-0434340432295537
Pubmed

Odorant receptor expressed sequence tags demonstrate olfactory expression of over 400 genes, extensive alternate splicing and unequal expression levels.

OR1L6 OR5L2 OR5B2 OR4C45

6.63e-0434640414611657
Pubmed

Cdc25A and Dub3 in a high-stakes balancing act.

USP17L7 USP17L13

6.66e-043340220228807
Pubmed

Polyclonal and monoclonal antibodies specific for USP17, a proapoptotic deubiquitinating enzyme.

USP17L7 USP17L13

7.07e-043440220715989
Pubmed

Human megasatellite DNA RS447: copy-number polymorphisms and interspecies conservation.

USP17L7 USP17L13

7.07e-04344029806828
Pubmed

The ubiquitin-specific protease 17 is involved in virus-triggered type I IFN signaling.

USP17L7 USP17L13

7.07e-043440220368735
Pubmed

The DUB/USP17 deubiquitinating enzymes, a multigene family within a tandemly repeated sequence.

USP17L7 USP17L13

7.07e-043440215780755
Pubmed

The DUB/USP17 deubiquitinating enzymes: a gene family within a tandemly repeated sequence, is also embedded within the copy number variable beta-defensin cluster.

USP17L7 USP17L13

7.07e-043440220403174
Pubmed

USP17 regulates Ras activation and cell proliferation by blocking RCE1 activity.

USP17L7 USP17L13

7.07e-043440219188362
Pubmed

Hyaluronan- and RNA-binding deubiquitinating enzymes of USP17 family members associated with cell viability.

USP17L7 USP17L13

7.07e-043440217109758
Pubmed

Unstable transmission of the RS447 human megasatellite tandem repetitive sequence that contains the USP17 deubiquitinating enzyme gene.

USP17L7 USP17L13

7.07e-043440211941478
Pubmed

The deubiquitinating enzyme USP17 is highly expressed in tumor biopsies, is cell cycle regulated, and is required for G1-S progression.

USP17L7 USP17L13

7.07e-043440220388806
Pubmed

DUB-3, a cytokine-inducible deubiquitinating enzyme that blocks proliferation.

USP17L7 USP17L13

7.07e-043440214699124
Pubmed

The RS447 human megasatellite tandem repetitive sequence encodes a novel deubiquitinating enzyme with a functional promoter.

USP17L7 USP17L13

7.07e-043440210936051
Pubmed

The deubiquitinating enzyme USP17 is essential for GTPase subcellular localization and cell motility.

USP17L7 USP17L13

7.07e-043440221448158
Pubmed

Lys-63-specific deubiquitination of SDS3 by USP17 regulates HDAC activity.

USP17L7 USP17L13

7.49e-043540221239494
Pubmed

Cytokine-regulated protein degradation by the ubiquitination system.

USP17L7 USP17L13

7.49e-043540216611142
Pubmed

The deubiquitinating enzyme USP17 blocks N-Ras membrane trafficking and activation but leaves K-Ras unaffected.

USP17L7 USP17L13

7.93e-043640220147298
Pubmed

Ubiquitin hydrolase Dub3 promotes oncogenic transformation by stabilizing Cdc25A.

USP17L7 USP17L13

8.37e-043740220228808
Pubmed

A trimeric Rab7 GEF controls NPC1-dependent lysosomal cholesterol export.

PRKCD NCBP1 TMEM214 DNAJC16

1.05e-0339240433144569
GeneFamilyZinc fingers C2H2-type|ZF class homeoboxes and pseudogenes

ZNF14 ZNF627 ZFP69B ZNF418 ZNF268 ZNF2 ZNF575

6.70e-0571827728
GeneFamilyAldehyde dehydrogenases

ALDH3B1 ALDH3B2

3.62e-0419272398
ComputationalOxidoreductases.

ALDH3B1 ALDH3B2

2.12e-0414172MODULE_464
ComputationalGenes in the cancer module 194.

ALDH3B1 ALDH3B2

2.44e-0415172MODULE_194
ComputationalOxidoreductases.

ALDH3B1 ALDH3B2

5.34e-0422172MODULE_373
DiseaseSjogren-Larsson syndrome (implicated_via_orthology)

ALDH3B1 ALDH3B2

2.29e-056372DOID:14501 (implicated_via_orthology)
DiseaseAutosomal Dominant Parkinsonism

PRKCD LRRK2

5.67e-0428372C0752098
DiseaseAutosomal Dominant Juvenile Parkinson Disease

PRKCD LRRK2

5.67e-0428372C0752097
DiseasePARKINSON DISEASE 2, AUTOSOMAL RECESSIVE JUVENILE

PRKCD LRRK2

5.67e-0428372C1868675
DiseaseParkinsonism, Experimental

PRKCD LRRK2

5.67e-0428372C0752101
DiseaseAutosomal Recessive Parkinsonism

PRKCD LRRK2

5.67e-0428372C0752100
DiseaseFamilial Juvenile Parkinsonism

PRKCD LRRK2

5.67e-0428372C0752104
DiseaseRamsay Hunt Paralysis Syndrome

PRKCD LRRK2

5.67e-0428372C0242423
DiseaseParkinsonism, Juvenile

PRKCD LRRK2

6.51e-0430372C0752105
DiseaseParkinsonian Disorders

PRKCD LRRK2

6.51e-0430372C0242422
Diseaseprimary ovarian insufficiency (implicated_via_orthology)

USP17L7 USP17L13

1.53e-0346372DOID:5426 (implicated_via_orthology)
Diseasecongenital heart disease (implicated_via_orthology)

USP17L7 USP17L13

3.40e-0369372DOID:1682 (implicated_via_orthology)
DiseaseNon-alcoholic Fatty Liver Disease

PRKCD EIF2AK1

3.50e-0370372C0400966
DiseaseNonalcoholic Steatohepatitis

PRKCD EIF2AK1

3.50e-0370372C3241937

Protein segments in the cluster

PeptideGeneStartEntry
SSFDLFKEIGHLCHL

DISP3

1041

Q9P2K9
KFSFDTFSHHRACLL

ALDH3B1

416

P43353
LHSKFHLCSVATRAL

AP2A1

526

O95782
SLRKSSSFHDDHFLS

CEP112

236

Q8N8E3
FTFDTFSHHRTCLLA

ALDH3B2

336

P48448
ATHEKLDFRLHFSCS

AP3D1

1031

O14617
DAKRAFNALCHSTHL

RBM19

886

Q9Y4C8
SLLFHFKETTATHCG

PGAP2

41

Q9UHJ9
LLHLAAKSFSHSFSA

NCBP1

551

Q09161
THLICTFQTKDHLFF

PRKCD

411

Q05655
FPSSREHHSFLKLCL

HERC1

781

Q15751
SALRLLFSFHKDGHT

FCRL6

141

Q6DN72
EGHLKALSSCASHIF

OR4C45

226

A6NMZ5
IFSLSFCKSNLVHHF

OR5B2

161

Q96R09
SSCLHFSFLSLDKHR

DNAJC16

651

Q9Y2G8
SLTHLDLHSNKFTSF

LRRK2

1036

Q5S007
FLHSDLALRNCFLTS

LMTK2

261

Q8IWU2
SFTCSDEFSSLRLHH

EIF2AK1

106

Q9BQI3
SHHFCFSIDLRSIHA

CEP120

451

Q8N960
HFASHLHKFLACLTD

DNAH2

196

Q9P225
DKLGSFFDLTFHHLC

DNAH2

2671

Q9P225
SRLSFCASHIIKHFF

OR1L6

201

Q8NGR2
SLFRTKHHARLSCGL

GPER1

166

Q99527
ATAHFSFCRTLLEHT

SAMD10

31

Q9BYL1
KSEHLSCSFTFFLHG

MED13

156

Q9UHV7
AESRHKAFSTCASHL

OR5L2

231

Q8NGL0
CGKAFSHRSSLSRHL

ZNF2

206

Q9BSG1
LHECSECRKTFSFHS

ZNF268

331

Q14587
DICFTKELHSHFFSL

TAFAZZIN

101

Q16635
CSSFANTSSKFRHLL

THAP9

881

Q9H5L6
FSFPSKLAAHRLCHD

ZNF575

186

Q86XF7
FLCHDLRSHSSFQAS

TMEM214

496

Q6NUQ4
SSKHISLCRELHTLF

USP49

351

Q70CQ1
HFSKLTSSRLDAAFA

USP17L13

16

C9JLJ4
AFSCSSSFRKHERIH

ZNF627

371

Q7L945
AQKLHLDSHLSFFAS

UNC5A

781

Q6ZN44
AFLALRSHFASSHAL

PRKDC

3896

P78527
AFSCSSSLIRHCKTH

ZFP69B

511

Q9UJL9
ECGKSFHRSSSLLRH

ZNF418

651

Q8TF45
HFSKLTSSRLDAAFA

USP17L7

16

P0C7H9
CHKTFSFSSSLREHE

ZNF14

396

P17017