Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
DomainPKD/REJ-like

PKDREJ KIAA0319L

7.36e-056422IPR002859
DomainREJ

PKDREJ KIAA0319L

7.36e-056422PF02010
DomainTGFb_propeptide

BMP4 BMP6

1.80e-0328422PF00688
DomainTGF-b_N

BMP4 BMP6

1.80e-0328422IPR001111
DomainTGF-beta-rel

BMP4 BMP6

2.35e-0332422IPR015615
DomainTGFb_CS

BMP4 BMP6

2.35e-0332422IPR017948
DomainTGFB

BMP4 BMP6

3.13e-0337422SM00204
DomainTGF-b_C

BMP4 BMP6

3.13e-0337422IPR001839
DomainTGF_BETA_2

BMP4 BMP6

3.13e-0337422PS51362
DomainTGF_beta

BMP4 BMP6

3.13e-0337422PF00019
DomainTGF_BETA_1

BMP4 BMP6

3.13e-0337422PS00250
Pubmed

Involvement of Bone Morphogenetic Protein-4 (BMP-4) and Vgr-1 in morphogenesis and neurogenesis in the mouse.

BMP4 BMP6

1.56e-0624421893873
Pubmed

Bone morphogenetic proteins differentially regulate pigmentation in human skin cells.

BMP4 BMP6

1.56e-06244222641693
Pubmed

Endogenous bone morphogenetic proteins mediate 1alpha, 25-dihydroxyvitamin D(3)-induced expression of osteoblast differentiation markers in human dermal fibroblasts.

BMP4 BMP6

1.56e-06244218683889
Pubmed

BMP4 substitutes for loss of BMP7 during kidney development.

BMP4 BMP6

4.69e-06344216154126
Pubmed

Bone morphogenetic proteins 4, 6, and 7 are up-regulated in mouse spinal cord during experimental autoimmune encephalomyelitis.

BMP4 BMP6

4.69e-06344217722066
Pubmed

Basolateral BMP signaling in polarized epithelial cells.

BMP4 BMP6

4.69e-06344223675417
Pubmed

Single-nucleotide polymorphisms and haplotypes of bone morphogenetic protein genes and peripheral bone mineral density in young Korean men and women.

BMP4 BMP6

4.69e-06344216604289
Pubmed

Bone morphogenetic proteins promote development of fetal pancreas epithelial colonies containing insulin-positive cells.

BMP4 BMP6

4.69e-06344211865031
Pubmed

The role of BMP-6, IL-6, and BMP-4 in mesenchymal stem cell-dependent bone development: effects on osteoblastic differentiation induced by parathyroid hormone and vitamin D(3).

BMP4 BMP6

4.69e-06344215186723
Pubmed

Immunohistochemical analysis revealed the expression of bone morphogenetic proteins-4, 6, 7, and 9 in human induced membrane samples treated with the Masquelet technique.

BMP4 BMP6

4.69e-06344235033126
Pubmed

Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.

HERC2 ARHGEF10 PCDHGA8 ZMYM3

9.34e-061044449205841
Pubmed

Prostate cancer induces bone metastasis through Wnt-induced bone morphogenetic protein-dependent and independent mechanisms.

BMP4 BMP6

9.37e-06444218632632
Pubmed

BMP6 and BMP4 expression in patients with cancer-related anemia and its relationship with hepcidin and s-HJV.

BMP4 BMP6

9.37e-06444227051019
Pubmed

BMPER, a novel endothelial cell precursor-derived protein, antagonizes bone morphogenetic protein signaling and endothelial cell differentiation.

BMP4 BMP6

9.37e-06444212897139
Pubmed

Immunohistochemical localization of bone morphogenetic proteins (BMPs) 2, 4, 6, and 7 during induced heterotopic bone formation.

BMP4 BMP6

9.37e-06444217262821
Pubmed

Antagonistic effects of bone morphogenetic protein-4 and -7 on renal mesangial cell proliferation induced by aldosterone through MAPK activation.

BMP4 BMP6

9.37e-06444217244894
Pubmed

Myosin V transports secretory vesicles via a Rab GTPase cascade and interaction with the exocyst complex.

EXOC6 EXOC3

9.37e-06444222172676
Pubmed

The in vivo Interaction Landscape of Histones H3.1 and H3.3.

NSD1 ACTL6A TAF2 ZNF680 HERC2 SPIN1 ZMYM3

1.05e-0560844736089195
Pubmed

Identification of a secreted BMP antagonist, ectodin, integrating BMP, FGF, and SHH signals from the tooth enamel knot.

BMP4 BMP6

1.56e-05544214623234
Pubmed

Histological development and dynamic expression of Bmp2-6 mRNAs in the embryonic and postnatal mouse cranial base.

BMP4 BMP6

1.56e-05544217066377
Pubmed

Expression of bone morphogenetic proteins in human metastatic prostate and breast cancer.

BMP4 BMP6

1.56e-05544215861517
Pubmed

Bmp6 and Bmp7 are required for cushion formation and septation in the developing mouse heart.

BMP4 BMP6

1.56e-05544211437450
Pubmed

Effect of bone morphogenetic proteins-4, -5 and -6 on DNA synthesis and expression of bone-related proteins in cultured human periodontal ligament cells.

BMP4 BMP6

1.56e-05544215516325
Pubmed

Effect of BMPs and Wnt3a co-expression on the osteogenetic capacity of osteoblasts.

BMP4 BMP6

2.34e-05644227633082
Pubmed

Hedgehog and Bmp genes are coexpressed at many diverse sites of cell-cell interaction in the mouse embryo.

BMP4 BMP6

2.34e-0564427589793
Pubmed

Regulation of ovarian function by the TGF-beta superfamily and follistatin.

BMP4 BMP6

2.34e-05644212887271
Pubmed

BMP mRNA and protein expression in the developing mouse olfactory system.

BMP4 BMP6

2.34e-05644212210138
Pubmed

The exocyst complex in polarized exocytosis.

EXOC6 EXOC3

2.34e-05644215037366
Pubmed

Bone morphogenetic protein signaling in the developing kidney: present and future.

BMP4 BMP6

2.34e-05644218331343
Pubmed

Overlapping expression domains of bone morphogenetic protein family members potentially account for limited tissue defects in BMP7 deficient embryos.

BMP4 BMP6

2.34e-0564429056639
Pubmed

Osteocyte control of bone formation via sclerostin, a novel BMP antagonist.

BMP4 BMP6

2.34e-05644214633986
Pubmed

Expression patterns of bone morphogenetic proteins (Bmps) in the developing mouse tooth suggest roles in morphogenesis and cell differentiation.

BMP4 BMP6

2.34e-0564429415424
Pubmed

Survival of Hoxa13 homozygous mutants reveals a novel role in digit patterning and appendicular skeletal development.

BMP4 BMP6

3.27e-05744220034107
Pubmed

Limbiting outgrowth: BMPs as negative regulators in limb development.

BMP4 BMP6

3.27e-05744210462412
Pubmed

BMP7 functions predominantly as a heterodimer with BMP2 or BMP4 during mammalian embryogenesis.

BMP4 BMP6

3.27e-05744231566563
Pubmed

Neuronal differentiation of precursors in the neocortical ventricular zone is triggered by BMP.

BMP4 BMP6

3.27e-0574429786991
Pubmed

A mammalian serine/threonine kinase receptor specifically binds BMP-2 and BMP-4.

BMP4 BMP6

3.27e-0574427811286
Pubmed

Direct and indirect roles of CNS dorsal midline cells in choroid plexus epithelia formation.

BMP4 BMP6

4.36e-05844215975937
Pubmed

The enamel knot as a signaling center in the developing mouse tooth.

BMP4 BMP6

4.36e-0584428808404
Pubmed

Mice lacking Bmp6 function.

BMP4 BMP6

4.36e-0584429664685
Pubmed

Bone morphogenetic proteins (BMPs) as regulators of dorsal forebrain development.

BMP4 BMP6

4.36e-0584429187146
Pubmed

The brain exocyst complex interacts with RalA in a GTP-dependent manner: identification of a novel mammalian Sec3 gene and a second Sec15 gene.

EXOC6 EXOC3

5.60e-05944211406615
Pubmed

Exorcising the exocyst complex.

EXOC6 EXOC3

5.60e-05944222420621
Pubmed

Proteomic analysis of HIV-1 Nef cellular binding partners reveals a role for exocyst complex proteins in mediating enhancement of intercellular nanotube formation.

EXOC6 EXOC3

5.60e-05944222534017
Pubmed

Osteogenic protein-2. A new member of the transforming growth factor-beta superfamily expressed early in embryogenesis.

BMP4 BMP6

5.60e-0594421460021
Pubmed

A novel chordin-like BMP inhibitor, CHL2, expressed preferentially in chondrocytes of developing cartilage and osteoarthritic joint cartilage.

BMP4 BMP6

5.60e-05944214660436
Pubmed

BMP2, but not BMP4, is crucial for chondrocyte proliferation and maturation during endochondral bone development.

BMP4 BMP6

5.60e-05944221984813
Pubmed

BMP6 is a key endogenous regulator of hepcidin expression and iron metabolism.

BMP4 BMP6

5.60e-05944219252486
Pubmed

Exploring the effects of gene dosage on mandible shape in mice as a model for studying the genetic basis of natural variation.

BMP4 BMP6

5.60e-05944223563729
Pubmed

In situ gene expression analysis during BMP2-induced ectopic bone formation in mice shows simultaneous endochondral and intramembranous ossification.

BMP4 BMP6

5.60e-05944212708796
Pubmed

Bone morphogenetic protein 6-induced interleukin-1β expression in macrophages requires PU.1/Smad1 interaction.

BMP4 BMP6

6.99e-051044221571370
Pubmed

BMP-2/4 and BMP-6/7 differentially utilize cell surface receptors to induce osteoblastic differentiation of human bone marrow-derived mesenchymal stem cells.

BMP4 BMP6

6.99e-051044218436533
Pubmed

Involvement of endogenous bone morphogenetic protein (BMP) 2 and BMP6 in bone formation.

BMP4 BMP6

6.99e-051044216109715
Pubmed

BMP-9 induces proliferation of multiple types of endothelial cells in vitro and in vivo.

BMP4 BMP6

8.54e-051144220406889
Pubmed

Bmp7 regulates germ cell proliferation in mouse fetal gonads.

BMP4 BMP6

1.21e-041344218391523
Pubmed

Apoptosis, proliferation and gene expression patterns in mouse developing tongue.

BMP4 BMP6

1.21e-041344216151852
Pubmed

RGMB and neogenin control cell differentiation in the developing olfactory epithelium.

BMP4 BMP6

1.21e-041344227143755
Pubmed

Hemojuvelin regulates hepcidin expression via a selective subset of BMP ligands and receptors independently of neogenin.

BMP4 BMP6

1.21e-041344218326817
Pubmed

Enhanced BMP signaling results in supernumerary tooth formation in USAG-1 deficient mouse.

BMP4 BMP6

1.21e-041344218329379
Pubmed

Genetic analysis of the roles of BMP2, BMP4, and BMP7 in limb patterning and skeletogenesis.

BMP4 BMP6

1.41e-041444217194222
Pubmed

Regulation of the ovarian reserve by members of the transforming growth factor beta family.

BMP4 BMP6

1.41e-041444222847922
Pubmed

Limb specific Acvr1-knockout during embryogenesis in mice exhibits great toe malformation as seen in Fibrodysplasia Ossificans Progressiva (FOP).

BMP4 BMP6

1.41e-041444230854720
Pubmed

The hem of the embryonic cerebral cortex is defined by the expression of multiple Wnt genes and is compromised in Gli3-deficient mice.

BMP4 BMP6

1.41e-04144429584130
Pubmed

Isl1 identifies a cardiac progenitor population that proliferates prior to differentiation and contributes a majority of cells to the heart.

BMP4 BMP6

1.41e-041444214667410
Pubmed

Cardiac outflow tract defects in mice lacking ALK2 in neural crest cells.

BMP4 BMP6

1.63e-041544215226263
Pubmed

Transient Impairment of Islet Architectural Development in Pancreas-Specific Bmpr1a-Deleted Prenatal Mice Involves Reduced Expression of E-Cadherin.

BMP4 BMP6

1.63e-041544228922976
Pubmed

The role of Foxg1 and dorsal midline signaling in the generation of Cajal-Retzius subtypes.

BMP4 BMP6

1.63e-041544217928452
Pubmed

Investigation of Crohn's disease risk loci in ulcerative colitis further defines their molecular relationship.

MUC19 HERC2

1.86e-041644219068216
Pubmed

Bmp5/7 in concert with the mid-hindbrain organizer control development of noradrenergic locus coeruleus neurons.

BMP4 BMP6

1.86e-041644220493948
Pubmed

Dorsoventral patterning of the telencephalon is disrupted in the mouse mutant extra-toes(J).

BMP4 BMP6

2.10e-041744210625551
Pubmed

Neural plate morphogenesis during mouse neurulation is regulated by antagonism of Bmp signalling.

BMP4 BMP6

2.10e-041744217693602
Pubmed

Bmp7 regulates the survival, proliferation, and neurogenic properties of neural progenitor cells during corticogenesis in the mouse.

BMP4 BMP6

2.10e-041744222461901
Pubmed

A disrupted balance between Bmp/Wnt and Fgf signaling underlies the ventralization of the Gli3 mutant telencephalon.

BMP4 BMP6

2.36e-041844212921747
Pubmed

p63 Suppresses non-epidermal lineage markers in a bone morphogenetic protein-dependent manner via repression of Smad7.

BMP4 BMP6

2.36e-041844219717565
Pubmed

Winged-helix, Hedgehog and Bmp genes are differentially expressed in distinct cell layers of the murine yolk sac.

BMP4 BMP6

2.36e-04184429152011
Pubmed

Dragon (repulsive guidance molecule b) inhibits IL-6 expression in macrophages.

BMP4 BMP6

2.64e-041944221187450
Pubmed

Biochemical and Cellular Analysis Reveals Ligand Binding Specificities, a Molecular Basis for Ligand Recognition, and Membrane Association-dependent Activities of Cripto-1 and Cryptic.

BMP4 BMP6

2.64e-041944228126904
Pubmed

The molecular and cellular signatures of the mouse eminentia thalami support its role as a signalling centre in the developing forebrain.

BMP4 BMP6

3.24e-042144226459142
Pubmed

Bmp signaling regulates a dose-dependent transcriptional program to control facial skeletal development.

KLF3 BMP4

3.24e-042144222219353
Pubmed

Chromosomal localization of seven members of the murine TGF-beta superfamily suggests close linkage to several morphogenetic mutant loci.

BMP4 BMP6

3.24e-04214421970330
Pubmed

Rnf165/Ark2C enhances BMP-Smad signaling to mediate motor axon extension.

BMP4 BMP6

3.24e-042144223610558
Pubmed

Primordial germ cell proliferation is impaired in Fused Toes mutant embryos.

BMP4 BMP6

3.56e-042244220969841
Pubmed

Endodermal Wnt signaling is required for tracheal cartilage formation.

BMP4 BMP6

3.89e-042344226093309
Pubmed

Endocardial to myocardial notch-wnt-bmp axis regulates early heart valve development.

BMP4 BMP6

4.61e-042544223560082
Pubmed

IkappaB kinase-alpha acts in the epidermis to control skeletal and craniofacial morphogenesis.

BMP4 BMP6

4.99e-042644215071597
Pubmed

An integrative method for scoring candidate genes from association studies: application to warfarin dosing.

EXOC6 SPIN1

5.38e-042744221044367
Pubmed

BMP-binding protein twisted gastrulation is required in mammary gland epithelium for normal ductal elongation and myoepithelial compartmentalization.

BMP4 BMP6

5.79e-042844223103586
Pubmed

Retrograde BMP signaling regulates trigeminal sensory neuron identities and the formation of precise face maps.

BMP4 BMP6

5.79e-042844217698011
Pubmed

Baf60c is essential for function of BAF chromatin remodelling complexes in heart development.

BMP4 ACTL6A

6.21e-042944215525990
Pubmed

BMP signaling negatively regulates bone mass through sclerostin by inhibiting the canonical Wnt pathway.

BMP4 BMP6

8.55e-043444218927151
Pubmed

Functional proteomics mapping of a human signaling pathway.

PEX19 BMP4 BTBD2 HERC2 KNL1

8.75e-0459144515231748
Pubmed

Disruption of genital ridge development causes aberrant primordial germ cell proliferation but does not affect their directional migration.

BMP4 BMP6

9.59e-043644223497137
Pubmed

Expansion of the renal capsular stroma, ureteric bud branching defects and cryptorchidism in mice with Wilms tumor 1 gene deletion in the stromal compartment of the developing kidney.

BMP4 FAT4

1.07e-033844232715478
Pubmed

Myocardial β-Catenin-BMP2 signaling promotes mesenchymal cell proliferation during endocardial cushion formation.

BMP4 BMP6

1.07e-033844230201295
Pubmed

Orphan quality control shapes network dynamics and gene expression.

ACTL6A KNL1

1.13e-033944237478862
Pubmed

Notch-Rbpj signaling is required for the development of noradrenergic neurons in the mouse locus coeruleus.

BMP4 BMP6

1.18e-034044222718343
Pubmed

TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.

EXOC6 FAT4 TAF2 ABCE1 KNL1

1.23e-0363844531182584
Pubmed

Dynamic spatiotemporal gene expression in embryonic mouse thalamus.

BMP4 BMP6

1.24e-034144221192082
GeneFamilyExocyst complex

EXOC6 EXOC3

1.30e-0493521055
GeneFamilyBone morphogenetic proteins|Astacins

BMP4 BMP6

1.98e-0411352455
GeneFamilyTudor domain containing

TDRD9 SPIN1

2.32e-0337352780
ToppCelldroplet-Fat-Scat-21m-Hematologic-nan|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

BMP6 CLCA2 RIMS2 MYO5C

1.90e-0692434246aebf5f17d50f67a7b48f713ea5043cefefb24
DiseaseMarfan syndrome (implicated_via_orthology)

BMP4 BMP6

8.01e-0510402DOID:14323 (implicated_via_orthology)
DiseaseGlobal developmental delay

BMP4 ACTL6A AGO1

7.83e-04133403C0557874
Diseaseskin pigmentation measurement

HERC2 RIMS2 MARCO

8.53e-04137403EFO_0007009
DiseaseFacial wrinkling

BMP6 RIMS2

1.16e-0337402HP_0009762

Protein segments in the cluster

PeptideGeneStartEntry
VKTMEVYPYLPHVVN

ERVPABLB-1

301

P60509
MKVNPYSVIDITPFQ

ARHGEF10

111

O15013
KYNPVVIDFEMQPIH

C8A

451

P07357
YPEEVSMIVNSHKPQ

CRYBG3

1066

Q68DQ2
IPQPLKDQATVHVYM

FAT4

1186

Q6V0I7
EQVAAQMPTVHYEFP

ACTL6A

276

O96019
EVVEYMVQHFKPQIF

AGO1

71

Q9UL18
HRINIYEVMKPPAEV

BMP4

176

P12644
QMPFNVVYAVSKAEP

CFAP91

156

Q7Z4T9
HEECVQKYPPTVMQN

NSD1

1616

Q96L73
VPHEVAQYIKFEMPV

RASSF4

266

Q9H2L5
VFPHPIYRVKVLENM

PCDHGA8

241

Q9Y5G5
QPVVVQPVPFMYTSH

KLF3

146

P57682
QVVDPIQTDPFKMYH

MAP4

131

P27816
AFVHRIPPSYVKMIQ

LGALS16

111

A8MUM7
VMKLIVINFPHPNVF

EPHX4

186

Q8IUS5
VPMEYNHLQEIPIIA

HERC2

4331

O95714
MVFFVQNEPPHQIFK

KIAA0319L

841

Q8IZA0
YFHVKLQIQIVPVMQ

MUC19

921

Q7Z5P9
MKVYVDDIYVIPQPH

KNL1

1456

Q8NG31
IPPVTMGFYVVKNVN

HPSE2

571

Q8WWQ2
MSQSVPHIYIQVKEF

EXOC6

481

Q8TAG9
KPQPYEEQMRIHAEV

RIMS2

376

Q9UQ26
PPEQFEKYQEQHSVM

PEX19

211

P40855
YTHPQFVTDVMKPLQ

ABCE1

436

P61221
VQTLVHLMNPEYVPK

BMP6

461

P22004
FHQIAMEPFEINVPK

MARCO

21

Q9UEW3
QEVFMANPIPKAAVY

DHRS7C

271

A6NNS2
IVAKNLMVQCFPPHY

EXOC3

291

O60645
VMFKEPVEVLPNVNY

BTBD2

451

Q9BX70
VVVQSMYIFKQPHFG

PHYHD1

136

Q5SRE7
VPVQNKMNPAYIFEV

TDRD9

301

Q8NDG6
VQMFYVAEPKQVPHI

HPS3

631

Q969F9
LNMIQNDPVPYVRHK

TAF2

911

Q6P1X5
THYVMAKVIVIPNPV

PKDREJ

1156

Q9NTG1
FPIYKVVFRQQIHAM

SLC25A53

46

Q5H9E4
LHFPHPVMIYANVKQ

CLCA2

616

Q9UQC9
ISQDKPPVLYTFHMV

SLFN12L

466

Q6IEE8
MVIHQVEAKPSVYFI

SPIN1

231

Q9Y657
MVDVKIFVNTIAYPP

PKHD1L1

1891

Q86WI1
KPQNTFPIYMVVHHE

ZMYND10

96

O75800
RQEMVAKPPVIYSHF

ZNF680

76

Q8NEM1
VPIFVPVPMHLYCQK

ZMYM3

871

Q14202
IYHQFIIIMEKNIQP

MYO5C

1496

Q9NQX4