Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	transporter activity	SLC46A2 SLC9A8 KCNA1 KCNA3 SLC2A6 TMEM165 KCNJ14 TMEM175 KCNK1 SLC19A2 CYB561D1 SLC4A10 SLCO4A1 KCNQ1 TMC5 SLC15A3 XKR4 SLC22A20P SLC66A1 MFSD10 GABRA4	4.22e-11	1289	59	21	GO:0005215
GeneOntologyMolecularFunction	transmembrane transporter activity	SLC46A2 SLC9A8 KCNA1 KCNA3 SLC2A6 TMEM165 KCNJ14 TMEM175 KCNK1 SLC19A2 CYB561D1 SLC4A10 SLCO4A1 KCNQ1 TMC5 SLC15A3 SLC22A20P SLC66A1 MFSD10 GABRA4	7.04e-11	1180	59	20	GO:0022857
GeneOntologyMolecularFunction	potassium ion transmembrane transporter activity	SLC9A8 KCNA1 KCNA3 KCNJ14 TMEM175 KCNK1 KCNQ1	5.97e-07	167	59	7	GO:0015079
GeneOntologyMolecularFunction	potassium channel activity	KCNA1 KCNA3 KCNJ14 TMEM175 KCNK1 KCNQ1	2.10e-06	128	59	6	GO:0005267
GeneOntologyMolecularFunction	organic anion transmembrane transporter activity	SLC46A2 SLC2A6 SLC19A2 SLC4A10 SLCO4A1 SLC22A20P SLC66A1 MFSD10	2.26e-06	293	59	8	GO:0008514
GeneOntologyMolecularFunction	monoatomic ion transmembrane transporter activity	SLC9A8 KCNA1 KCNA3 TMEM165 KCNJ14 TMEM175 KCNK1 SLC4A10 KCNQ1 TMC5 SLC15A3 GABRA4	2.84e-06	793	59	12	GO:0015075
GeneOntologyMolecularFunction	metal ion transmembrane transporter activity	SLC9A8 KCNA1 KCNA3 TMEM165 KCNJ14 TMEM175 KCNK1 SLC4A10 KCNQ1	8.34e-06	465	59	9	GO:0046873
GeneOntologyMolecularFunction	inorganic molecular entity transmembrane transporter activity	SLC9A8 KCNA1 KCNA3 TMEM165 KCNJ14 TMEM175 KCNK1 SLC4A10 KCNQ1 SLC15A3 GABRA4	1.16e-05	758	59	11	GO:0015318
GeneOntologyMolecularFunction	voltage-gated potassium channel activity	KCNA1 KCNA3 KCNJ14 KCNK1 KCNQ1	1.27e-05	102	59	5	GO:0005249
GeneOntologyMolecularFunction	inorganic cation transmembrane transporter activity	SLC9A8 KCNA1 KCNA3 TMEM165 KCNJ14 TMEM175 KCNK1 SLC4A10 KCNQ1 SLC15A3	1.36e-05	627	59	10	GO:0022890
GeneOntologyMolecularFunction	monoatomic cation transmembrane transporter activity	SLC9A8 KCNA1 KCNA3 TMEM165 KCNJ14 TMEM175 KCNK1 SLC4A10 KCNQ1 SLC15A3	2.23e-05	664	59	10	GO:0008324
GeneOntologyMolecularFunction	threonine-tRNA ligase activity	TARS3 TARS2	2.57e-05	3	59	2	GO:0004829
GeneOntologyMolecularFunction	gated channel activity	KCNA1 KCNA3 KCNJ14 KCNK1 KCNQ1 TMC5 GABRA4	5.56e-05	334	59	7	GO:0022836
GeneOntologyMolecularFunction	monoatomic ion channel activity	KCNA1 KCNA3 KCNJ14 TMEM175 KCNK1 KCNQ1 TMC5 GABRA4	5.82e-05	459	59	8	GO:0005216
GeneOntologyMolecularFunction	outward rectifier potassium channel activity	KCNA3 KCNK1 KCNQ1	6.81e-05	27	59	3	GO:0015271
GeneOntologyMolecularFunction	delayed rectifier potassium channel activity	KCNA1 KCNA3 KCNQ1	7.62e-05	28	59	3	GO:0005251
GeneOntologyMolecularFunction	voltage-gated monoatomic cation channel activity	KCNA1 KCNA3 KCNJ14 KCNK1 KCNQ1	8.60e-05	152	59	5	GO:0022843
GeneOntologyMolecularFunction	voltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	KCNA1 KCNK1	1.28e-04	6	59	2	GO:1905030
GeneOntologyMolecularFunction	channel activity	KCNA1 KCNA3 KCNJ14 TMEM175 KCNK1 KCNQ1 TMC5 GABRA4	1.48e-04	525	59	8	GO:0015267
GeneOntologyMolecularFunction	passive transmembrane transporter activity	KCNA1 KCNA3 KCNJ14 TMEM175 KCNK1 KCNQ1 TMC5 GABRA4	1.50e-04	526	59	8	GO:0022803
GeneOntologyMolecularFunction	voltage-gated monoatomic ion channel activity	KCNA1 KCNA3 KCNJ14 KCNK1 KCNQ1	2.00e-04	182	59	5	GO:0005244
GeneOntologyMolecularFunction	voltage-gated channel activity	KCNA1 KCNA3 KCNJ14 KCNK1 KCNQ1	2.11e-04	184	59	5	GO:0022832
GeneOntologyMolecularFunction	secondary active transmembrane transporter activity	SLC46A2 SLC9A8 TMEM165 SLC4A10 SLCO4A1 SLC15A3	2.35e-04	296	59	6	GO:0015291
GeneOntologyMolecularFunction	mannosyl-oligosaccharide 1,2-alpha-mannosidase activity	MAN1A2 MAN1A1	2.38e-04	8	59	2	GO:0004571
GeneOntologyMolecularFunction	ligase activity, forming carbon-oxygen bonds	TARS3 TARS2 CARS2	2.59e-04	42	59	3	GO:0016875
GeneOntologyMolecularFunction	aminoacyl-tRNA ligase activity	TARS3 TARS2 CARS2	2.59e-04	42	59	3	GO:0004812
GeneOntologyMolecularFunction	mannosyl-oligosaccharide mannosidase activity	MAN1A2 MAN1A1	3.80e-04	10	59	2	GO:0015924
GeneOntologyMolecularFunction	active transmembrane transporter activity	SLC46A2 SLC9A8 TMEM165 CYB561D1 SLC4A10 SLCO4A1 SLC15A3	4.96e-04	477	59	7	GO:0022804
GeneOntologyMolecularFunction	monoatomic cation channel activity	KCNA1 KCNA3 KCNJ14 TMEM175 KCNK1 KCNQ1	5.15e-04	343	59	6	GO:0005261
GeneOntologyMolecularFunction	azole transmembrane transporter activity	SLC19A2 SLC66A1	7.63e-04	14	59	2	GO:1901474
GeneOntologyMolecularFunction	alpha-mannosidase activity	MAN1A2 MAN1A1	8.79e-04	15	59	2	GO:0004559
GeneOntologyMolecularFunction	mannosidase activity	MAN1A2 MAN1A1	1.00e-03	16	59	2	GO:0015923
GeneOntologyMolecularFunction	potassium ion leak channel activity	TMEM175 KCNK1	1.00e-03	16	59	2	GO:0022841
GeneOntologyMolecularFunction	G protein-coupled receptor activity	GHSR OR4A8 P2RY12 OR11H7 OR9Q2 GPR84 OR14J1 OPN1SW ADGRL3	1.08e-03	884	59	9	GO:0004930
GeneOntologyMolecularFunction	narrow pore channel activity	TMEM175 KCNK1	1.42e-03	19	59	2	GO:0022842
GeneOntologyMolecularFunction	leak channel activity	TMEM175 KCNK1	1.42e-03	19	59	2	GO:0022840
GeneOntologyMolecularFunction	transmembrane signaling receptor activity	GHSR ITGA11 OR4A8 P2RY12 OR11H7 OR9Q2 GPR84 OR14J1 OPN1SW ADGRL3 GABRA4	1.82e-03	1353	59	11	GO:0004888
GeneOntologyMolecularFunction	inward rectifier potassium channel activity	KCNJ14 KCNK1	3.09e-03	28	59	2	GO:0005242
GeneOntologyMolecularFunction	hydrolase activity, hydrolyzing O-glycosyl compounds	KL MAN1A2 MAN1A1	3.51e-03	103	59	3	GO:0004553
GeneOntologyMolecularFunction	vitamin transmembrane transporter activity	SLC2A6 SLC19A2	5.07e-03	36	59	2	GO:0090482
GeneOntologyMolecularFunction	amide transmembrane transporter activity	SLC19A2 SLC15A3	6.85e-03	42	59	2	GO:0042887
GeneOntologyMolecularFunction	metal cation:monoatomic cation antiporter activity	SLC9A8 SLC4A10	7.17e-03	43	59	2	GO:0140828
GeneOntologyMolecularFunction	antiporter activity	SLC9A8 TMEM165 SLC4A10	7.92e-03	138	59	3	GO:0015297
GeneOntologyMolecularFunction	catalytic activity, acting on a tRNA	TARS3 TARS2 CARS2	8.89e-03	144	59	3	GO:0140101
GeneOntologyMolecularFunction	hydrolase activity, acting on glycosyl bonds	KL MAN1A2 MAN1A1	8.89e-03	144	59	3	GO:0016798
GeneOntologyBiologicalProcess	potassium ion transmembrane transport	SLC9A8 KCNA1 KCNA3 P2RY12 KCNJ14 TMEM175 KCNK1 KCNQ1	3.07e-07	232	59	8	GO:0071805
GeneOntologyBiologicalProcess	potassium ion transport	SLC9A8 KCNA1 KCNA3 P2RY12 KCNJ14 TMEM175 KCNK1 KCNQ1	1.02e-06	272	59	8	GO:0006813
GeneOntologyBiologicalProcess	monoatomic ion transport	SLC9A8 KCNA1 KCNA3 P2RY12 TMEM165 KCNJ14 TMEM175 KCNK1 SLC4A10 SLCO4A1 KCNQ1 TMC5 SLC15A3 SLC22A20P GABRA4	5.14e-06	1374	59	15	GO:0006811
GeneOntologyBiologicalProcess	engulfment of apoptotic cell	XKR4 RAC1 RAC3	9.87e-06	15	59	3	GO:0043652
GeneOntologyBiologicalProcess	monoatomic ion transmembrane transport	SLC9A8 KCNA1 KCNA3 P2RY12 TMEM165 KCNJ14 TMEM175 KCNK1 SLC4A10 KCNQ1 TMC5 SLC15A3 GABRA4	1.24e-05	1115	59	13	GO:0034220
GeneOntologyBiologicalProcess	threonyl-tRNA aminoacylation	TARS3 TARS2	2.41e-05	3	59	2	GO:0006435
GeneOntologyBiologicalProcess	inorganic ion transmembrane transport	SLC9A8 KCNA1 KCNA3 P2RY12 TMEM165 KCNJ14 TMEM175 KCNK1 SLC4A10 KCNQ1 SLC15A3 GABRA4	2.53e-05	1017	59	12	GO:0098660
GeneOntologyBiologicalProcess	inorganic cation transmembrane transport	SLC9A8 KCNA1 KCNA3 P2RY12 TMEM165 KCNJ14 TMEM175 KCNK1 SLC4A10 KCNQ1 SLC15A3	5.24e-05	922	59	11	GO:0098662
GeneOntologyBiologicalProcess	monoatomic cation transmembrane transport	SLC9A8 KCNA1 KCNA3 P2RY12 TMEM165 KCNJ14 TMEM175 KCNK1 SLC4A10 KCNQ1 SLC15A3	6.36e-05	942	59	11	GO:0098655
GeneOntologyBiologicalProcess	forebrain development	PTCHD1 KCNA1 KCNA3 P2RY12 SRD5A2 SLC4A10 RAC1 RAC3	7.23e-05	489	59	8	GO:0030900
GeneOntologyBiologicalProcess	nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway	SLC46A2 SLC15A3 NOD2	8.54e-05	30	59	3	GO:0035872
GeneOntologyBiologicalProcess	organic anion transport	SLC46A2 SLC2A6 SLC19A2 SLC4A10 SLCO4A1 SLC22A20P SLC66A1 MFSD10	1.04e-04	515	59	8	GO:0015711
GeneOntologyBiologicalProcess	cell adhesion mediated by integrin	ITGA11 PDE3B P2RY12 RAC3	1.34e-04	91	59	4	GO:0033627
GeneOntologyBiologicalProcess	regulation of intracellular pH	SLC9A8 TMEM165 TMEM175 SLC4A10	1.52e-04	94	59	4	GO:0051453
GeneOntologyBiologicalProcess	amide transport	GHSR PDE3B SLC19A2 DIO2 KCNQ1 SLC15A3 RAC1	1.89e-04	420	59	7	GO:0042886
GeneOntologyBiologicalProcess	regulation of cellular pH	SLC9A8 TMEM165 TMEM175 SLC4A10	2.00e-04	101	59	4	GO:0030641
GeneOntologyBiologicalProcess	auditory receptor cell development	KCNQ1 TECTA RAC1	2.04e-04	40	59	3	GO:0060117
GeneOntologyBiologicalProcess	negative regulation of macrophage apoptotic process	GHSR NOD2	2.23e-04	8	59	2	GO:2000110
GeneOntologyBiologicalProcess	ubiquitin-dependent glycoprotein ERAD pathway	MAN1A2 MAN1A1	2.23e-04	8	59	2	GO:0097466
GeneOntologyBiologicalProcess	protein deglycosylation involved in glycoprotein catabolic process	MAN1A2 MAN1A1	2.23e-04	8	59	2	GO:0035977
GeneOntologyBiologicalProcess	cerebral cortex GABAergic interneuron development	RAC1 RAC3	2.23e-04	8	59	2	GO:0021894
GeneOntologyBiologicalProcess	protein alpha-1,2-demannosylation	MAN1A2 MAN1A1	2.23e-04	8	59	2	GO:0036508
GeneOntologyBiologicalProcess	protein demannosylation	MAN1A2 MAN1A1	2.23e-04	8	59	2	GO:0036507
GeneOntologyBiologicalProcess	positive regulation of nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway	SLC46A2 SLC15A3	2.23e-04	8	59	2	GO:0070426
GeneOntologyBiologicalProcess	mannose trimming involved in glycoprotein ERAD pathway	MAN1A2 MAN1A1	2.23e-04	8	59	2	GO:1904382
GeneOntologyBiologicalProcess	tRNA aminoacylation for protein translation	TARS3 TARS2 CARS2	2.36e-04	42	59	3	GO:0006418
GeneOntologyBiologicalProcess	tRNA aminoacylation	TARS3 TARS2 CARS2	2.90e-04	45	59	3	GO:0043039
GeneOntologyBiologicalProcess	positive regulation of substrate adhesion-dependent cell spreading	MYADM RAC1 RAC3	3.09e-04	46	59	3	GO:1900026
GeneOntologyBiologicalProcess	amino acid activation	TARS3 TARS2 CARS2	3.09e-04	46	59	3	GO:0043038
GeneOntologyBiologicalProcess	apoptotic cell clearance	XKR4 RAC1 RAC3	3.51e-04	48	59	3	GO:0043277
GeneOntologyBiologicalProcess	monoatomic cation transport	SLC9A8 KCNA1 KCNA3 P2RY12 TMEM165 KCNJ14 TMEM175 KCNK1 SLC4A10 KCNQ1 SLC15A3	3.85e-04	1157	59	11	GO:0006812
GeneOntologyBiologicalProcess	regulation of pH	SLC9A8 TMEM165 TMEM175 SLC4A10	3.87e-04	120	59	4	GO:0006885
GeneOntologyBiologicalProcess	regulation of cell adhesion mediated by integrin	PDE3B P2RY12 RAC3	3.96e-04	50	59	3	GO:0033628
GeneOntologyBiologicalProcess	negative regulation of norepinephrine secretion	GHSR P2RY12	4.35e-04	11	59	2	GO:0010700
GeneOntologyBiologicalProcess	cerebral cortex GABAergic interneuron differentiation	RAC1 RAC3	4.35e-04	11	59	2	GO:0021892
GeneOntologyBiologicalProcess	metal ion transport	SLC9A8 KCNA1 KCNA3 P2RY12 TMEM165 KCNJ14 TMEM175 KCNK1 SLC4A10 KCNQ1	4.95e-04	1000	59	10	GO:0030001
GeneOntologyBiologicalProcess	G protein-coupled receptor signaling pathway	GHSR PDE3B OR4A8 P2RY12 OR11H7 OR9Q2 GPR84 KCNQ1 OR14J1 OPN1SW ADGRL3 RAC1	5.00e-04	1395	59	12	GO:0007186
GeneOntologyBiologicalProcess	peptide transport	GHSR PDE3B DIO2 KCNQ1 SLC15A3 RAC1	5.21e-04	355	59	6	GO:0015833
GeneOntologyBiologicalProcess	regulation of macrophage apoptotic process	GHSR NOD2	5.21e-04	12	59	2	GO:2000109
GeneOntologyBiologicalProcess	response to glycoprotein	MAN1A2 MAN1A1	5.21e-04	12	59	2	GO:1904587
GeneOntologyBiologicalProcess	regulation of neutrophil migration	RAC1 RAC3 NOD2	6.45e-04	59	59	3	GO:1902622
GeneOntologyBiologicalProcess	negative regulation of insulin secretion	GHSR PDE3B KCNQ1	7.46e-04	62	59	3	GO:0046676
GeneOntologyBiologicalProcess	organic cation transport	GHSR P2RY12 SLC19A2 SLC66A1	7.90e-04	145	59	4	GO:0015695
GeneOntologyBiologicalProcess	sodium-independent organic anion transport	SLCO4A1 MFSD10	8.25e-04	15	59	2	GO:0043252
GeneOntologyBiologicalProcess	macrophage apoptotic process	GHSR NOD2	8.25e-04	15	59	2	GO:0071888
GeneOntologyBiologicalProcess	azole transmembrane transport	SLC19A2 SLC66A1	8.25e-04	15	59	2	GO:0045117
GeneOntologyBiologicalProcess	response to nitrogen compound	GHSR PDE3B KL MAN1A2 MAN1A1 P2RY12 SRD5A2 KCNQ1 ADGRL3 RAC1 NOD2	8.50e-04	1272	59	11	GO:1901698
GeneOntologyBiologicalProcess	regulation of substrate adhesion-dependent cell spreading	MYADM RAC1 RAC3	8.95e-04	66	59	3	GO:1900024
GeneOntologyBiologicalProcess	inner ear auditory receptor cell differentiation	KCNQ1 TECTA RAC1	9.35e-04	67	59	3	GO:0042491
GeneOntologyBiologicalProcess	regulation of nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway	SLC46A2 SLC15A3	9.41e-04	16	59	2	GO:0070424
GeneOntologyBiologicalProcess	detection of stimulus	KCNA1 OR4A8 OR11H7 OR9Q2 KCNQ1 OR14J1 OPN1SW NOD2	9.93e-04	722	59	8	GO:0051606
GeneOntologyBiologicalProcess	phagocytosis, engulfment	XKR4 RAC1 RAC3	1.02e-03	69	59	3	GO:0006911
GeneOntologyBiologicalProcess	locomotion involved in locomotory behavior	GHSR ADGRL3	1.06e-03	17	59	2	GO:0031987
GeneOntologyBiologicalProcess	phagocytosis	TMEM175 XKR4 RAC1 RAC3 NOD2	1.11e-03	274	59	5	GO:0006909
GeneOntologyBiologicalProcess	regulation of neuron maturation	RAC1 RAC3	1.19e-03	18	59	2	GO:0014041
GeneOntologyBiologicalProcess	protein deglycosylation	MAN1A2 MAN1A1	1.19e-03	18	59	2	GO:0006517
GeneOntologyBiologicalProcess	inner ear receptor cell development	KCNQ1 TECTA RAC1	1.20e-03	73	59	3	GO:0060119
GeneOntologyBiologicalProcess	negative regulation of peptide hormone secretion	GHSR PDE3B KCNQ1	1.20e-03	73	59	3	GO:0090278
GeneOntologyBiologicalProcess	synaptic transmission, GABAergic	RAC1 RAC3 GABRA4	1.25e-03	74	59	3	GO:0051932
GeneOntologyBiologicalProcess	negative regulation of peptide secretion	GHSR PDE3B KCNQ1	1.30e-03	75	59	3	GO:0002792
GeneOntologyBiologicalProcess	proton transmembrane transport	SLC9A8 TMEM175 SLC4A10 SLC15A3	1.42e-03	170	59	4	GO:1902600
GeneOntologyBiologicalProcess	hormone transport	GHSR PDE3B DIO2 SLCO4A1 KCNQ1 RAC1	1.44e-03	432	59	6	GO:0009914
GeneOntologyBiologicalProcess	hair cell differentiation	KCNQ1 TECTA RAC1	1.45e-03	78	59	3	GO:0035315
GeneOntologyBiologicalProcess	plasma membrane invagination	XKR4 RAC1 RAC3	1.45e-03	78	59	3	GO:0099024
GeneOntologyBiologicalProcess	nucleotide-binding oligomerization domain containing 2 signaling pathway	SLC15A3 NOD2	1.48e-03	20	59	2	GO:0070431
GeneOntologyBiologicalProcess	response to follicle-stimulating hormone	GHSR SRD5A2	1.63e-03	21	59	2	GO:0032354
GeneOntologyCellularComponent	voltage-gated potassium channel complex	KCNA1 KCNA3 KCNJ14 KCNK1 KCNQ1	6.33e-06	91	60	5	GO:0008076
GeneOntologyCellularComponent	potassium channel complex	KCNA1 KCNA3 KCNJ14 KCNK1 KCNQ1	1.22e-05	104	60	5	GO:0034705
GeneOntologyCellularComponent	cation channel complex	KCNA1 KCNA3 KCNJ14 KCNK1 KCNQ1	5.68e-04	235	60	5	GO:0034703
GeneOntologyCellularComponent	monoatomic ion channel complex	KCNA1 KCNA3 KCNJ14 KCNK1 KCNQ1 GABRA4	7.39e-04	378	60	6	GO:0034702
GeneOntologyCellularComponent	cytoplasmic vesicle membrane	SLC46A2 SLC9A8 TM9SF2 TMEM165 VPS35L TMEM175 GPR84 KCNQ1 SLC15A3 MFSD10 RAC1	1.10e-03	1307	60	11	GO:0030659
GeneOntologyCellularComponent	NADPH oxidase complex	RAC1 RAC3	1.20e-03	18	60	2	GO:0043020
GeneOntologyCellularComponent	vesicle membrane	SLC46A2 SLC9A8 TM9SF2 TMEM165 VPS35L TMEM175 GPR84 KCNQ1 SLC15A3 MFSD10 RAC1	1.23e-03	1325	60	11	GO:0012506
GeneOntologyCellularComponent	cell body	KCNA1 P2RY12 KCNJ14 SRD5A2 KCNK1 SLC4A10 KCNQ1 OPN1SW RAC3	1.25e-03	929	60	9	GO:0044297
GeneOntologyCellularComponent	synaptic membrane	GHSR KCNA1 KCNA3 KCNK1 ADGRL3 RAC1 GABRA4	1.36e-03	583	60	7	GO:0097060
GeneOntologyCellularComponent	endosome membrane	SLC46A2 SLC9A8 TM9SF2 TMEM165 TMEM175 SLC15A3 RAC1	1.63e-03	602	60	7	GO:0010008
GeneOntologyCellularComponent	endosome	SLC46A2 SLC9A8 TM9SF2 TMEM165 VPS35L TMEM175 KCNK1 KCNQ1 SLC15A3 RAC1	1.66e-03	1167	60	10	GO:0005768
GeneOntologyCellularComponent	plasma membrane protein complex	ITGA11 KCNA1 KCNA3 KCNJ14 KCNK1 KCNQ1 RAC1 RAC3	1.74e-03	785	60	8	GO:0098797
GeneOntologyCellularComponent	apical plasma membrane	SLC9A8 KL KCNA1 KCNK1 SLC4A10 KCNQ1	2.68e-03	487	60	6	GO:0016324
GeneOntologyCellularComponent	axon terminus	KCNA1 KCNA3 SLC4A10 OPN1SW	3.11e-03	210	60	4	GO:0043679
GeneOntologyCellularComponent	basal plasma membrane	P2RY12 SLC4A10 SLCO4A1 KCNQ1 NOD2	3.45e-03	354	60	5	GO:0009925
GeneOntologyCellularComponent	membrane raft	GHSR MYADM KCNA3 P2RY12 KCNQ1	3.79e-03	362	60	5	GO:0045121
GeneOntologyCellularComponent	transmembrane transporter complex	KCNA1 KCNA3 KCNJ14 KCNK1 KCNQ1 GABRA4	3.80e-03	523	60	6	GO:1902495
GeneOntologyCellularComponent	membrane microdomain	GHSR MYADM KCNA3 P2RY12 KCNQ1	3.88e-03	364	60	5	GO:0098857
GeneOntologyCellularComponent	Golgi membrane	SLC9A8 MAN1A2 MAN1A1 TMEM165 ZDHHC19 HUWE1 RAC1	4.46e-03	721	60	7	GO:0000139
GeneOntologyCellularComponent	neuron projection terminus	KCNA1 KCNA3 SLC4A10 OPN1SW	4.50e-03	233	60	4	GO:0044306
GeneOntologyCellularComponent	basal part of cell	P2RY12 SLC4A10 SLCO4A1 KCNQ1 NOD2	4.55e-03	378	60	5	GO:0045178
GeneOntologyCellularComponent	calyx of Held	KCNA1 KCNA3	4.79e-03	36	60	2	GO:0044305
GeneOntologyCellularComponent	transporter complex	KCNA1 KCNA3 KCNJ14 KCNK1 KCNQ1 GABRA4	4.86e-03	550	60	6	GO:1990351
Domain	MFS_dom	SLC46A2 SLC2A6 SLC19A2 SLCO4A1 SLC15A3 SLC22A20P MFSD10	1.64e-07	134	57	7	IPR020846
Domain	MFS	SLC46A2 SLC2A6 SLCO4A1 SLC22A20P MFSD10	1.94e-05	108	57	5	PS50850
Domain	ThrRS_core	TARS3 TARS2	2.74e-05	3	57	2	IPR033728
Domain	Thr-tRNA-ligase_IIa	TARS3 TARS2	2.74e-05	3	57	2	IPR002320
Domain	-	RASA4 RASA4B	2.74e-05	3	57	2	4.10.1130.10
Domain	TGS	TARS3 TARS2	1.36e-04	6	57	2	IPR004095
Domain	TGS	TARS3 TARS2	1.36e-04	6	57	2	PF02824
Domain	VG_K_chnl	KCNA1 KCNA3 KCNQ1	1.38e-04	33	57	3	IPR028325
Domain	-	MAN1A2 MAN1A1	1.90e-04	7	57	2	1.50.10.50
Domain	TGS-like	TARS3 TARS2	1.90e-04	7	57	2	IPR012676
Domain	tRNA_SAD	TARS3 TARS2	1.90e-04	7	57	2	SM00863
Domain	tRNA_SAD	TARS3 TARS2	1.90e-04	7	57	2	IPR012947
Domain	Glyco_hydro_47	MAN1A2 MAN1A1	1.90e-04	7	57	2	PF01532
Domain	tRNA_SAD	TARS3 TARS2	1.90e-04	7	57	2	PF07973
Domain	K_chnl_volt-dep_Kv1	KCNA1 KCNA3	2.53e-04	8	57	2	IPR003972
Domain	Thr/Ala-tRNA-synth_IIc_edit	TARS3 TARS2	2.53e-04	8	57	2	IPR018163
Domain	Glyco_hydro_47	MAN1A2 MAN1A1	2.53e-04	8	57	2	IPR001382
Domain	BTK	RASA4 RASA4B	3.25e-04	9	57	2	SM00107
Domain	ZF_BTK	RASA4 RASA4B	3.25e-04	9	57	2	PS51113
Domain	Znf_Btk_motif	RASA4 RASA4B	3.25e-04	9	57	2	IPR001562
Domain	HGTP_anticodon	TARS3 TARS2	3.25e-04	9	57	2	PF03129
Domain	BTK	RASA4 RASA4B	3.25e-04	9	57	2	PF00779
Domain	aa-tRNA-synt_IIb	TARS3 TARS2	4.94e-04	11	57	2	IPR002314
Domain	tRNA-synt_2b	TARS3 TARS2	4.94e-04	11	57	2	PF00587
Domain	-	TARS3 TARS2	4.94e-04	11	57	2	3.40.50.800
Domain	RasGAP	RASA4 RASA4B	8.13e-04	14	57	2	SM00323
Domain	Anticodon-bd	TARS3 TARS2	8.13e-04	14	57	2	IPR004154
Domain	Beta-grasp_dom	TARS3 TARS2	8.13e-04	14	57	2	IPR012675
Domain	RasGAP_CS	RASA4 RASA4B	8.13e-04	14	57	2	IPR023152
Domain	-	TARS3 TARS2	8.13e-04	14	57	2	3.10.20.30
Domain	RAS_GTPASE_ACTIV_2	RASA4 RASA4B	9.37e-04	15	57	2	PS50018
Domain	RasGAP	RASA4 RASA4B	9.37e-04	15	57	2	PF00616
Domain	RAS_GTPASE_ACTIV_1	RASA4 RASA4B	9.37e-04	15	57	2	PS00509
Domain	-	RASA4 RASA4B	1.07e-03	16	57	2	1.10.506.10
Domain	aa-tRNA-synth_II	TARS3 TARS2	1.36e-03	18	57	2	IPR006195
Domain	RasGAP_dom	RASA4 RASA4B	1.36e-03	18	57	2	IPR001936
Domain	AA_TRNA_LIGASE_II	TARS3 TARS2	1.36e-03	18	57	2	PS50862
Domain	RHO	RAC1 RAC3	1.68e-03	20	57	2	PS51420
Domain	K_chnl_volt-dep_Kv	KCNA1 KCNA3	3.06e-03	27	57	2	IPR003968
Domain	Ion_trans_dom	KCNA1 KCNA3 KCNQ1	5.10e-03	114	57	3	IPR005821
Domain	Ion_trans	KCNA1 KCNA3 KCNQ1	5.10e-03	114	57	3	PF00520
Domain	Sugar_tr	SLC2A6 SLC22A20P	5.39e-03	36	57	2	PF00083
Domain	MFS_sugar_transport-like	SLC2A6 SLC22A20P	5.39e-03	36	57	2	IPR005828
Domain	BTB_2	KCNA1 KCNA3	1.14e-02	53	57	2	PF02214
Domain	T1-type_BTB	KCNA1 KCNA3	1.14e-02	53	57	2	IPR003131
Pathway	REACTOME_POTASSIUM_CHANNELS	KCNA1 KCNA3 KCNJ14 KCNK1 KCNQ1	1.44e-05	98	45	5	MM14545
Pathway	REACTOME_POTASSIUM_CHANNELS	KCNA1 KCNA3 KCNJ14 KCNK1 KCNQ1	1.83e-05	103	45	5	M1073
Pathway	KEGG_MEDICUS_REFERENCE_ITGA_B_RHOG_RAC_SIGNALING_PATHWAY	ITGA11 RAC1 RAC3	9.42e-05	28	45	3	M47655
Pathway	REACTOME_N_GLYCAN_TRIMMING_AND_ELONGATION_IN_THE_CIS_GOLGI	MAN1A2 MAN1A1	9.90e-05	5	45	2	M27954
Pathway	REACTOME_N_GLYCAN_TRIMMING_AND_ELONGATION_IN_THE_CIS_GOLGI	MAN1A2 MAN1A1	9.90e-05	5	45	2	MM15670
Pathway	KEGG_MEDICUS_REFERENCE_ITGA_B_FAK_RAC_SIGNALING_PATHWAY	ITGA11 RAC1 RAC3	1.16e-04	30	45	3	M47718
Pathway	KEGG_MEDICUS_PATHOGEN_HCMV_GH_TO_ITGA_B_RHOA_SIGNALING_PATHWAY	RAC1 RAC3	2.07e-04	7	45	2	M47538
Pathway	REACTOME_NEURONAL_SYSTEM	KCNA1 KCNA3 KCNJ14 KCNK1 KCNQ1 RAC1 GABRA4	2.96e-04	411	45	7	M735
Pathway	KEGG_AMINOACYL_TRNA_BIOSYNTHESIS	TARS3 TARS2 CARS2	2.98e-04	41	45	3	M14691
Pathway	REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS	KCNA1 KCNA3 KCNQ1	2.98e-04	41	45	3	MM14546
Pathway	REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS	KCNA1 KCNA3 KCNQ1	3.43e-04	43	45	3	M1056
Pathway	KEGG_MEDICUS_REFERENCE_IGG_FCGR_RAC_SIGNALING_PATHWAY	RAC1 RAC3	4.41e-04	10	45	2	M47727
Pathway	REACTOME_NEURONAL_SYSTEM	KCNA1 KCNA3 KCNJ14 KCNK1 KCNQ1 GABRA4	6.42e-04	335	45	6	MM14503
Pathway	WP_RALA_DOWNSTREAM_REGULATED_GENES	RAC1 RAC3	6.44e-04	12	45	2	M39408
Pathway	BIOCARTA_BARRESTIN_PATHWAY	KCNA1 KCNA3	6.44e-04	12	45	2	M7772
Pathway	BIOCARTA_BARR_MAPK_PATHWAY	KCNA1 KCNA3	8.85e-04	14	45	2	M668
Pathway	REACTOME_SLC_MEDIATED_TRANSMEMBRANE_TRANSPORT	SLC9A8 SLC2A6 SLC4A10 SLCO4A1 SLC15A3	9.26e-04	238	45	5	MM15076
Pathway	BIOCARTA_AMAN_PATHWAY	MAN1A2 MAN1A1	1.02e-03	15	45	2	M22009
Pathway	REACTOME_SLC_MEDIATED_TRANSMEMBRANE_TRANSPORT	SLC9A8 SLC2A6 SLC4A10 SLCO4A1 SLC15A3	1.13e-03	249	45	5	M5988
Pathway	KEGG_MEDICUS_REFERENCE_N_GLYCAN_BIOSYNTHESIS	MAN1A2 MAN1A1	1.16e-03	16	45	2	M47632
Pathway	BIOCARTA_BARRESTIN_SRC_PATHWAY	KCNA1 KCNA3	1.31e-03	17	45	2	M111
Pathway	REACTOME_PHASE_4_RESTING_MEMBRANE_POTENTIAL	KCNJ14 KCNK1	1.65e-03	19	45	2	M27452
Pathway	REACTOME_PHASE_4_RESTING_MEMBRANE_POTENTIAL	KCNJ14 KCNK1	1.65e-03	19	45	2	MM15194
Pathway	BIOCARTA_ERAD_PATHWAY	MAN1A2 MAN1A1	1.65e-03	19	45	2	M22013
Pubmed	KCNE2 forms potassium channels with KCNA3 and KCNQ1 in the choroid plexus epithelium.	KCNA1 KCNA3 KCNQ1	2.72e-07	8	60	3	21859894
Pubmed	Rac-deficient cerebellar granule neurons die before they migrate to the internal granule layer.	RAC1 RAC3	2.93e-06	2	60	2	36050459
Pubmed	Rac1 and Rac3 have opposite functions in Schwann cells during developmental myelination.	RAC1 RAC3	2.93e-06	2	60	2	33812927
Pubmed	Identification of a Protein Network Driving Neuritogenesis of MGE-Derived GABAergic Interneurons.	RAC1 RAC3	2.93e-06	2	60	2	28066185
Pubmed	Rac-Dependent Signaling from Keratinocytes Promotes Differentiation of Intradermal White Adipocytes.	RAC1 RAC3	2.93e-06	2	60	2	31351086
Pubmed	CAPRI regulates Ca(2+)-dependent inactivation of the Ras-MAPK pathway.	RASA4 RASA4B	2.93e-06	2	60	2	11448776
Pubmed	Roles of the Rac1 and Rac3 GTPases in human tumor cell invasion.	RAC1 RAC3	2.93e-06	2	60	2	16027728
Pubmed	Pharmacogenetics of KCNQ channel activation in 2 potassium channelopathy mouse models of epilepsy.	KCNA1 KCNQ1	2.93e-06	2	60	2	29265344
Pubmed	Functional role of Kv1.1 and Kv1.3 channels in the neoplastic progression steps of three cancer cell lines, elucidated by scorpion peptides.	KCNA1 KCNA3	2.93e-06	2	60	2	29415410
Pubmed	Dispensable role of Rac1 and Rac3 after cochlear hair cell specification.	RAC1 RAC3	2.93e-06	2	60	2	37204479
Pubmed	Rac1 and Rac3 isoform activation is involved in the invasive and metastatic phenotype of human breast cancer cells.	RAC1 RAC3	2.93e-06	2	60	2	16280046
Pubmed	Rac1 and Rac3 GTPases differently influence the morphological maturation of dendritic spines in hippocampal neurons.	RAC1 RAC3	2.93e-06	2	60	2	31369617
Pubmed	RAC1B function is essential for breast cancer stem cell maintenance and chemoresistance of breast tumor cells.	RAC1 RAC3	2.93e-06	2	60	2	36599922
Pubmed	Absence of Rac1 and Rac3 GTPases in the nervous system hinders thymic, splenic and immune-competence development.	RAC1 RAC3	2.93e-06	2	60	2	21469092
Pubmed	Rac1 and Rac3 have opposing functions in cell adhesion and differentiation of neuronal cells.	RAC1 RAC3	2.93e-06	2	60	2	17244648
Pubmed	Attenuation of apoptotic cell detection triggers thymic regeneration after damage.	RAC1 NOD2	2.93e-06	2	60	2	34610317
Pubmed	A C-terminally amidated analogue of ShK is a potent and selective blocker of the voltage-gated potassium channel Kv1.3.	KCNA1 KCNA3	2.93e-06	2	60	2	23063513
Pubmed	NOD2-mediated P2Y12 upregulation increases platelet activation and thrombosis in sepsis.	P2RY12 NOD2	2.93e-06	2	60	2	34748820
Pubmed	An essential function for the calcium-promoted Ras inactivator in Fcgamma receptor-mediated phagocytosis.	RASA4 RASA4B	2.93e-06	2	60	2	16041389
Pubmed	Perivascular deletion of murine Rac reverses the ratio of marrow arterioles and sinusoid vessels and alters hematopoiesis in vivo.	RAC1 RAC3	2.93e-06	2	60	2	25824687
Pubmed	Rac1 and Rac3 GTPases regulate the development of hilar mossy cells by affecting the migration of their precursors to the hilus.	RAC1 RAC3	2.93e-06	2	60	2	21949760
Pubmed	Loss of Either Rac1 or Rac3 GTPase Differentially Affects the Behavior of Mutant Mice and the Development of Functional GABAergic Networks.	RAC1 RAC3	2.93e-06	2	60	2	26582364
Pubmed	Large-scale analysis of ion channel gene expression in the mouse heart during perinatal development.	KCNA1 KCNA3 KCNJ14 KCNK1 KCNQ1	4.34e-06	139	60	5	16985003
Pubmed	Upregulation of KCNQ1/KCNE1 K+ channels by Klotho.	KL KCNQ1	8.77e-06	3	60	2	24457979
Pubmed	Characterization of a cDNA encoding a novel human Golgi alpha 1, 2-mannosidase (IC) involved in N-glycan biosynthesis.	MAN1A2 MAN1A1	8.77e-06	3	60	2	10915796
Pubmed	Isoform-specific membrane targeting mechanism of Rac during Fc gamma R-mediated phagocytosis: positive charge-dependent and independent targeting mechanism of Rac to the phagosome.	RAC1 RAC3	8.77e-06	3	60	2	16081809
Pubmed	Signaling and cytoskeletal requirements in erythroblast enucleation.	RAC1 RAC3	8.77e-06	3	60	2	22461493
Pubmed	CD28 inhibits T cell adhesion by recruiting CAPRI to the plasma membrane.	RASA4 RASA4B	8.77e-06	3	60	2	25637021
Pubmed	Novel role of Rac-Mid1 signaling in medial cerebellar development.	RAC1 RAC3	8.77e-06	3	60	2	28512198
Pubmed	RAC1B modulates intestinal tumourigenesis via modulation of WNT and EGFR signalling pathways.	RAC1 RAC3	8.77e-06	3	60	2	33879799
Pubmed	Isolation of a mouse Golgi mannosidase cDNA, a member of a gene family conserved from yeast to mammals.	MAN1A2 MAN1A1	8.77e-06	3	60	2	8144579
Pubmed	rac, a novel ras-related family of proteins that are botulinum toxin substrates.	RAC1 RAC3	8.77e-06	3	60	2	2674130
Pubmed	Rho family GTPases, Rac and Cdc42, control the localization of neonatal dentate granule cells during brain development.	RAC1 RAC3	8.77e-06	3	60	2	30387892
Pubmed	MYADM regulates Rac1 targeting to ordered membranes required for cell spreading and migration.	MYADM RAC1	8.77e-06	3	60	2	21325632
Pubmed	Rac signaling in osteoblastic cells is required for normal bone development but is dispensable for hematopoietic development.	RAC1 RAC3	8.77e-06	3	60	2	22123845
Pubmed	Molecular cloning, chromosomal mapping and tissue-specific expression of a novel human alpha1,2-mannosidase gene involved in N-glycan maturation.	MAN1A2 MAN1A1	8.77e-06	3	60	2	9592125
Pubmed	The Rac activator DOCK7 regulates neuronal polarity through local phosphorylation of stathmin/Op18.	RAC1 RAC3	8.77e-06	3	60	2	16982419
Pubmed	Pathophysiological Mechanisms in Neurodevelopmental Disorders Caused by Rac GTPases Dysregulation: What's behind Neuro-RACopathies.	RAC1 RAC3	8.77e-06	3	60	2	34943902
Pubmed	A family of three mouse potassium channel genes with intronless coding regions.	KCNA1 KCNA3	8.77e-06	3	60	2	2305265
Pubmed	PAK is required for the disruption of E-cadherin adhesion by the small GTPase Rac.	RAC1 RAC3	1.75e-05	4	60	2	18319303
Pubmed	Rap1-Rac1 circuits potentiate platelet activation.	P2RY12 RAC1	1.75e-05	4	60	2	22075250
Pubmed	Ca2+-dependent monomer and dimer formation switches CAPRI Protein between Ras GTPase-activating protein (GAP) and RapGAP activities.	RASA4 RASA4B	1.75e-05	4	60	2	21460216
Pubmed	KCNE4 is an inhibitory subunit to Kv1.1 and Kv1.3 potassium channels.	KCNA1 KCNA3	1.75e-05	4	60	2	12944270
Pubmed	Identification of an alternatively spliced variant of Ca2+-promoted Ras inactivator as a possible regulator of RANKL shedding.	RASA4 RASA4B	1.75e-05	4	60	2	16234249
Pubmed	K+ current diversity is produced by an extended gene family conserved in Drosophila and mouse.	KCNA1 KCNA3	2.92e-05	5	60	2	2333511
Pubmed	Contribution of Kv1.2 voltage-gated potassium channel to D2 autoreceptor regulation of axonal dopamine overflow.	KCNA1 KCNA3	2.92e-05	5	60	2	21233214
Pubmed	Rac1 and rac3 GTPases control synergistically the development of cortical and hippocampal GABAergic interneurons.	RAC1 RAC3	2.92e-05	5	60	2	23258346
Pubmed	Subunit composition of Kv1 channels in human CNS.	KCNA1 KCNA3	2.92e-05	5	60	2	10428084
Pubmed	PTEN negatively regulates engulfment of apoptotic cells by modulating activation of Rac GTPase.	RAC1 RAC3	2.92e-05	5	60	2	22043008
Pubmed	Endosomes are specialized platforms for bacterial sensing and NOD2 signalling.	SLC15A3 NOD2	4.37e-05	6	60	2	24695226
Pubmed	Rac1 and Rac3 GTPases and TPC2 are required for axonal outgrowth and migration of cortical interneurons.	RAC1 RAC3	4.37e-05	6	60	2	36744839
Pubmed	Differential K+ channel clustering activity of PSD-95 and SAP97, two related membrane-associated putative guanylate kinases.	KCNA1 KCNA3	4.37e-05	6	60	2	8938729
Pubmed	Physical mapping of potassium channel gene clusters on mouse chromosomes three and six.	KCNA1 KCNA3	4.37e-05	6	60	2	9286706
Pubmed	Truncation of the Shaker-like voltage-gated potassium channel, Kv1.1, causes megencephaly.	KCNA1 KCNA3	4.37e-05	6	60	2	14686897
Pubmed	International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels.	KCNA1 KCNA3 KCNQ1	4.61e-05	40	60	3	16382104
Pubmed	PRCD is concentrated at the base of photoreceptor outer segments and is involved in outer segment disc formation.	P2RY12 OPN1SW	6.11e-05	7	60	2	31628458
Pubmed	Clustering of Shaker-type K+ channels by interaction with a family of membrane-associated guanylate kinases.	KCNA1 KCNA3	6.11e-05	7	60	2	7477295
Pubmed	Respiratory distress and neonatal lethality in mice lacking Golgi alpha1,2-mannosidase IB involved in N-glycan maturation.	MAN1A2 MAN1A1	8.14e-05	8	60	2	17121831
Pubmed	Generation and characterization of Rac3 knockout mice.	RAC1 RAC3	8.14e-05	8	60	2	15964829
Pubmed	Role of the Rho GTPase Rac in the activation of the phagocyte NADPH oxidase: outsourcing a key task.	RAC1 RAC3	8.14e-05	8	60	2	24598074
Pubmed	Comparative genome mapping in the sequence-based era: early experience with human chromosome 7.	RASA4 RASA4B	8.14e-05	8	60	2	10810084
Pubmed	N-terminal PDZ-binding domain in Kv1 potassium channels.	KCNA1 KCNA3	8.14e-05	8	60	2	12435606
Pubmed	Different noses for different people.	OR4A8 OR11H7	8.14e-05	8	60	2	12730696
Pubmed	CYBA encoding p22(phox), the cytochrome b558 alpha polypeptide: gene structure, expression, role and physiopathology.	RAC1 RAC3	8.14e-05	8	60	2	27048830
Pubmed	Genomic organization, chromosomal localization, tissue distribution, and biophysical characterization of a novel mammalian Shaker-related voltage-gated potassium channel, Kv1.7.	KCNA1 KCNA3	1.05e-04	9	60	2	9488722
Pubmed	Developmental expression of voltage-sensitive K+ channels in mouse skeletal muscle and C2C12 cells.	KCNA1 KCNA3	1.31e-04	10	60	2	1383027
Pubmed	Regulation of lymphatic-blood vessel separation by endothelial Rac1.	RAC1 RAC3	1.31e-04	10	60	2	19906871
Pubmed	Methotrexate suppresses psoriatic skin inflammation by inhibiting muropeptide transporter SLC46A2 activity.	SLC46A2 NOD2	1.31e-04	10	60	2	37116499
Pubmed	The human formin FHOD1 contains a bipartite structure of FH3 and GTPase-binding domains required for activation.	RAC1 RAC3	1.59e-04	11	60	2	18786395
Pubmed	Differential distribution of Rac1 and Rac3 GTPases in the developing mouse brain: implications for a role of Rac3 in Purkinje cell differentiation.	RAC1 RAC3	2.26e-04	13	60	2	14622142
Pubmed	Rac-GTPases Regulate Microtubule Stability and Axon Growth of Cortical GABAergic Interneurons.	RAC1 RAC3	2.26e-04	13	60	2	24626607
Pubmed	Rac1 controls the formation of midline commissures and the competency of tangential migration in ventral telencephalic neurons.	RAC1 RAC3	2.63e-04	14	60	2	17409253
Pubmed	Toward the full set of human mitochondrial aminoacyl-tRNA synthetases: characterization of AspRS and TyrRS.	TARS2 CARS2	2.63e-04	14	60	2	15779907
Pubmed	Essential role of Rac1 and Rac3 GTPases in neuronal development.	RAC1 RAC3	2.63e-04	14	60	2	19126596
Pubmed	Infectivities of human and other primate lentiviruses are activated by desialylation of the virion surface.	MAN1A2 MAN1A1	3.03e-04	15	60	2	8892864
Pubmed	Targeting CAG repeat RNAs reduces Huntington's disease phenotype independently of huntingtin levels.	PDE3B P2RY12	3.46e-04	16	60	2	27721240
Pubmed	Alteration of Neuronal Excitability and Short-Term Synaptic Plasticity in the Prefrontal Cortex of a Mouse Model of Mental Illness.	KCNA1 KCNA3	3.46e-04	16	60	2	28283561
Pubmed	Impaired OTUD7A-dependent Ankyrin regulation mediates neuronal dysfunction in mouse and human models of the 15q13.3 microdeletion syndrome.	KCNA1 KCNA3 ADGRL3 RAC3	3.80e-04	197	60	4	36604605
Pubmed	Meta-analysis of genome-wide association studies in African Americans provides insights into the genetic architecture of type 2 diabetes.	TMEM175 KCNQ1	3.91e-04	17	60	2	25102180
Pubmed	Assignment of intrachain disulfide bonds and characterization of potential glycosylation sites of the type 1 recombinant human immunodeficiency virus envelope glycoprotein (gp120) expressed in Chinese hamster ovary cells.	MAN1A2 MAN1A1	3.91e-04	17	60	2	2355006
Pubmed	Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV.	TM9SF2 SLC2A6 ST7 SLC19A2 SLC4A10 HUWE1 TARS2 MFSD10	4.59e-04	1061	60	8	33845483
Pubmed	Proteomics characterization of abundant Golgi membrane proteins.	MAN1A2 MAN1A1	4.91e-04	19	60	2	11042173
Pubmed	Glycosylation inhibitors and neuraminidase enhance human immunodeficiency virus type 1 binding and neutralization by mannose-binding lectin.	MAN1A2 MAN1A1	5.45e-04	20	60	2	12560567
Pubmed	Influence of N-linked glycans in V4-V5 region of human immunodeficiency virus type 1 glycoprotein gp160 on induction of a virus-neutralizing humoral response.	MAN1A2 MAN1A1	6.61e-04	22	60	2	8673525
Pubmed	Effect of various glycosidase treatments on the resistance of the HIV-1 envelope to degradation.	MAN1A2 MAN1A1	6.61e-04	22	60	2	9109416
Pubmed	Folding of the human immunodeficiency virus type 1 envelope glycoprotein in the endoplasmic reticulum.	MAN1A2 MAN1A1	6.61e-04	22	60	2	11530211
Pubmed	Role of asparagine-linked glycosylation in human immunodeficiency virus type 1 transmembrane envelope function.	MAN1A2 MAN1A1	7.23e-04	23	60	2	1736542
Pubmed	Functional role of the glycan cluster of the human immunodeficiency virus type 1 transmembrane glycoprotein (gp41) ectodomain.	MAN1A2 MAN1A1	7.23e-04	23	60	2	8093218
Pubmed	Glycosylation inhibitors block the expression of LAV/HTLV-III (HIV) glycoproteins.	MAN1A2 MAN1A1	7.23e-04	23	60	2	3099781
Pubmed	Role of protein N-glycosylation in pathogenesis of human immunodeficiency virus type 1.	MAN1A2 MAN1A1	7.23e-04	23	60	2	3264072
Pubmed	The Catalytically Inactive Mutation of the Ubiquitin-Conjugating Enzyme CDC34 Affects its Stability and Cell Proliferation.	TMEM165 ACTL6A TARS2 RAC1	7.60e-04	237	60	4	29564676
Pubmed	Phosphodiesterase 2A2 regulates mitochondria clearance through Parkin-dependent mitophagy.	TMEM165 HUWE1 MFSD10	8.30e-04	106	60	3	33087821
Pubmed	Effect of N-(3-phenyl-2-propenyl)-1-deoxynojirimycin on the lectin binding to HIV-1 glycoproteins.	MAN1A2 MAN1A1	8.56e-04	25	60	2	2283726
Pubmed	Semaphorin heterodimerization in cis regulates membrane targeting and neocortical wiring.	RAC1 RAC3	9.26e-04	26	60	2	39152101
Pubmed	Chromosomal mapping in the mouse of eight K(+)-channel genes representing the four Shaker-like subfamilies Shaker, Shab, Shaw, and Shal.	KCNA1 KCNA3	9.26e-04	26	60	2	7905852
Pubmed	Redundant functions of Rac GTPases in inner ear morphogenesis.	RAC1 RAC3	9.26e-04	26	60	2	22182523
Pubmed	Site-specific N-glycosylation and oligosaccharide structures of recombinant HIV-1 gp120 derived from a baculovirus expression system.	MAN1A2 MAN1A1	9.26e-04	26	60	2	8218172
Pubmed	Developmental gene expression profiling along the tonotopic axis of the mouse cochlea.	KCNQ1 TECTA	1.07e-03	28	60	2	22808246
Pubmed	LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.	PDE3B MAN1A1 TM9SF2 TMEM165 SLC19A2 HUWE1 TARS2	1.16e-03	942	60	7	31073040
Pubmed	Voltage-gated potassium channel genes are clustered in paralogous regions of the mouse genome.	KCNA1 KCNA3	1.32e-03	31	60	2	8034307
Interaction	CLDND1 interactions	MYADM MAN1A2 MAN1A1 RAC1 RAC3	1.33e-06	70	55	5	int:CLDND1
Interaction	KCNE4 interactions	MYADM KCNA1 KCNA3 KCNQ1	3.80e-06	39	55	4	int:KCNE4
Interaction	ARL6IP5 interactions	KCNA3 P2RY12 ST7 KCNK1 RAC1 RAC3	1.36e-05	192	55	6	int:ARL6IP5
Interaction	SRPRB interactions	PDE3B KCNA3 ST7 HUWE1 RAC1 RAC3 NOD2	3.24e-05	333	55	7	int:SRPRB
Interaction	ATP1B3 interactions	KCNA3 TM9SF2 HUWE1 SLC15A3 RAC1 RAC3	3.85e-05	231	55	6	int:ATP1B3
Interaction	AUP1 interactions	KCNA3 ST7 HUWE1 SLC15A3 RAC1 RAC3	4.14e-05	234	55	6	int:AUP1
Interaction	IGSF3 interactions	MYADM KCNK1 RAC1 RAC3	4.21e-05	71	55	4	int:IGSF3
Interaction	CARMIL1 interactions	KCNA3 HUWE1 RAC1 RAC3	7.41e-05	82	55	4	int:CARMIL1
Interaction	MICAL3 interactions	KCNA3 ST7 RAC1 RAC3	1.02e-04	89	55	4	int:MICAL3
Interaction	TBC1D10B interactions	KCNA3 HUWE1 RAC1 RAC3	1.16e-04	92	55	4	int:TBC1D10B
Interaction	IGDCC4 interactions	MYADM MAN1A1 ST7	1.18e-04	35	55	3	int:IGDCC4
Interaction	SRPRA interactions	TMEM182 KCNA3 ST7 KCNK1 RAC1 RAC3	1.25e-04	286	55	6	int:SRPRA
Interaction	ARHGDIA interactions	KCNA3 ACTL6A NPEPL1 RAC1 RAC3	1.37e-04	182	55	5	int:ARHGDIA
Interaction	YIPF3 interactions	PCNX3 P2RY12 KCNK1 SLC19A2 ADGRL3	1.52e-04	186	55	5	int:YIPF3
Interaction	VKORC1L1 interactions	P2RY12 ST7 KCNK1 SLC15A3	1.54e-04	99	55	4	int:VKORC1L1
Interaction	CLCC1 interactions	KCNA3 ST7 SLC15A3 RAC1 RAC3	1.68e-04	190	55	5	int:CLCC1
Interaction	ALDH3A2 interactions	KCNA3 ST7 HUWE1 SLC15A3 RAC1 RAC3	1.75e-04	304	55	6	int:ALDH3A2
Interaction	LBR interactions	KCNA3 ST7 HUWE1 SLC15A3 RAC1 RAC3	1.75e-04	304	55	6	int:LBR
Interaction	SUN3 interactions	PCYOX1L ADGRL3	2.03e-04	8	55	2	int:SUN3
Interaction	ZDHHC5 interactions	KCNA3 RAC1 RAC3 NOD2	2.39e-04	111	55	4	int:ZDHHC5
Interaction	MTMR1 interactions	KCNA3 HUWE1 RAC1 RAC3	2.39e-04	111	55	4	int:MTMR1
Interaction	PCDHAC2 interactions	PDE3B PCNX3 ST7	2.52e-04	45	55	3	int:PCDHAC2
Interaction	SLCO4A1 interactions	SLCO4A1 RAC1 RAC3	2.69e-04	46	55	3	int:SLCO4A1
Interaction	SIGMAR1 interactions	GHSR KCNK1 GPR84 RAC1	2.93e-04	117	55	4	int:SIGMAR1
GeneFamily	Solute carriers	SLC46A2 SLC9A8 SLC2A6 SLC19A2 SLC4A10 SLCO4A1 SLC15A3 SLC22A20P	4.31e-06	395	44	8	752
GeneFamily	Mannosidases alpha class 1	MAN1A2 MAN1A1	3.46e-05	4	44	2	1193
GeneFamily	Potassium voltage-gated channels	KCNA1 KCNA3 KCNQ1	1.25e-04	40	44	3	274
GeneFamily	Pleckstrin homology domain containing\|SH2 domain containing\|C2 and RasGAP domain containing	RASA4 RASA4B	2.57e-04	10	44	2	830
GeneFamily	Rho family GTPases	RAC1 RAC3	1.07e-03	20	44	2	390
Coexpression	BENPORATH_SUZ12_TARGETS	GHSR SLC46A2 PTCHD1 ITGA11 KL KCNA1 KCNA3 SRD5A2 SLCO4A1 SLC66A1 ADGRL3 GABRA4	1.85e-06	1035	57	12	M9898
ToppCell	facs-Trachea-24m-Hematologic-myeloid-granulocyte-granulocyte_l8\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	SLC2A6 ZDHHC19 SLC15A3 SLC22A20P NOD2	2.00e-06	153	60	5	338684d420b01e32918fa19048ccdda234942ce1
ToppCell	PND10-Immune-Immune_Myeloid-Monocytic-Macrophage-IM-IM_prolif\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	P2RY12 RASA4 GPR84 SLC15A3 STAG3	2.57e-06	161	60	5	8937f6b92cb2a93ea8c4780d9200a518c3112e53
ToppCell	facs-Brain_Myeloid-Hippocampus-3m-Myeloid\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PDE3B MAN1A2 MAN1A1 TM9SF2 P2RY12	6.22e-06	193	60	5	06b65110db974f4ef90d3511ff34428976a52c9c
ToppCell	facs-Brain_Myeloid-Hippocampus-3m-Myeloid-microglial_cell\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PDE3B MAN1A2 MAN1A1 TM9SF2 P2RY12	6.22e-06	193	60	5	9c16032bc03df8760ae199e8f19fdafa4c3f1827
ToppCell	facs-Brain_Myeloid-Hippocampus-3m\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PDE3B MAN1A2 MAN1A1 TM9SF2 P2RY12	6.22e-06	193	60	5	a4f91bca5eaa985982d33a528f7566ffde154d47
ToppCell	facs-Brain_Myeloid-Hippocampus-3m-Myeloid-nan\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PDE3B MAN1A2 MAN1A1 TM9SF2 P2RY12	6.22e-06	193	60	5	b39d7feaac4ff8f7409cd3d15e8f3c6391367275
Disease	autosomal dominant intellectual developmental disorder 48 (implicated_via_orthology)	RAC1 RAC3	1.02e-05	3	55	2	DOID:0080235 (implicated_via_orthology)
Disease	amino acid metabolic disorder (implicated_via_orthology)	TARS3 TARS2	2.04e-05	4	55	2	DOID:9252 (implicated_via_orthology)
Disease	kidney disease (implicated_via_orthology)	KL RAC1 RAC3	6.21e-05	41	55	3	DOID:557 (implicated_via_orthology)
Disease	Mental Retardation, X-Linked Nonsyndromic	PTCHD1 HUWE1	2.63e-04	13	55	2	C3501611
Disease	Parkinson disease	PTCHD1 TMEM175 TMC5 CARS2 NOD2	3.29e-04	321	55	5	MONDO_0005180
Disease	phosphatidylcholine 40:6 measurement	TMC5 NOD2	4.56e-04	17	55	2	EFO_0010389
Disease	susceptibility to pneumonia measurement	TMEM182 MAN1A2 SLC2A6	7.98e-04	97	55	3	EFO_0008410
Disease	attention deficit hyperactivity disorder (implicated_via_orthology)	PTCHD1 ADGRL3	1.25e-03	28	55	2	DOID:1094 (implicated_via_orthology)
Disease	chronic kidney disease (biomarker_via_orthology)	KL SLC19A2	1.25e-03	28	55	2	DOID:784 (biomarker_via_orthology)
Disease	Intellectual Disability	PTCHD1 SLC4A10 ACTL6A RAC1 RAC3	1.46e-03	447	55	5	C3714756

Protein segments in the cluster

Peptide	Gene	Start	Entry
ILLFSPEHSLFFFCS	CYB561D1	71	Q8N8Q1
IPAFFLCKTAVLTAF	ACTL6A	146	O96019
ACAVFAALLHFFFLA	ADGRL3	926	Q9HAR2
VPFIAVTSFLCLRFF	RASA4	461	O43374
DVFLICFSLVSPASF	RAC3	76	P60763
VPFIAVTSFLCLRFF	RASA4B	461	C9J798
DVFLICFSLVSPASF	RAC1	76	P63000
ACFTTWSGLFLLPFF	MFSD10	426	Q14728
RCAAQFFLFTFFASI	OR9Q2	96	Q8NGE9
PVFFSNCLFLALYDS	DIO2	16	Q92813
CFSVFAISFFALPAG	KCNQ1	331	P51787
LVVRFFACPSKTDFF	KCNA1	236	Q09470
ILCFAASTFPQFIKA	SLC66A1	46	Q6ZP29
LLGFVTVSCFFFIPA	KCNK1	186	O00180
TVSCFFFIPAAVFSV	KCNK1	191	O00180
RDVATVFTLCFPFVF	PCNX3	901	Q9H6A9
FANILTTDFPSFFCT	PCYOX1L	356	Q8NBM8
FSTCLPHLFVATFFL	OR14J1	236	Q9UGF5
FASACALARAFPLFT	NPEPL1	121	Q8NDH3
PLFSIACAFFFLTCF	PDE3B	121	Q13370
FSFELLVRFFACPSK	KCNA3	306	P22001
FPITFACYAALFCLS	MYADM	101	Q96S97
CFAFVFSALIEFAAV	GABRA4	326	P48169
ATCLAAFLCFTPIFL	ITGA11	666	Q9UKX5
LTSLNACLDPFIYFF	P2RY12	286	Q9H244
LQVPFFFFAAICLVS	SLC2A6	461	Q9UGQ3
FRLTFFICSVGFTSP	HUWE1	1126	Q7Z6Z7
CFAVFLCFALSYIPF	GPR84	321	Q9NQS5
PCFSHVASFLAAFLF	KCNJ14	126	Q9UNX9
VSSIFFFLPVFCLTV	GHSR	216	Q92847
FITLCFGAIFFLPDS	MAN1A1	51	P33908
FITLCFGAFFFLPDS	MAN1A2	46	O60476
FFALCFGPTLSFQLL	KL	366	Q9UEF7
CLQFAISAPFLIFFL	SLC22A20P	251	A6NK97
CVGLAFFIFLFATPV	SLC15A3	236	Q8IY34
FLPTALLCAYGFFAS	SLC19A2	31	O60779
HSISIFFIFQLPFCG	OR11H7	156	Q8NGC8
FLLCIFSVFPVFVAS	OPN1SW	81	P03999
PVYFFLACLSFIDAV	OR4A8	56	P0C604
LFFFHDLSPGSCFFL	TARS3	411	A2RTX5
LFFFHELSPGSCFFL	TARS2	311	Q9BW92
FLKTFSPDVFRFFCL	CARS2	331	Q9HA77
CLFLIAFVTFFHCFA	PTCHD1	826	Q96NR3
CVFAFLGLSIFSFPH	SLC9A8	361	Q9Y2E8
ELPFFILFTAGLCSF	ST7	511	Q9NRC1
FFAIACFLYKPLSES	SLCO4A1	681	Q96BD0
SPATPLSFLFFFFLC	LINC00477	21	Q96M19
LSFLFFFFLCRAGSS	LINC00477	26	Q96M19
CPFSGTSFVVFSLFL	CLECL1	61	Q8IZS7
AFLRFPANCAFVLST	TECTA	1501	O75443
CFAAAIFSLFFVPLS	TMEM175	196	Q9BSA9
RPSESFLLEFLCNFF	VPS35L	766	Q7Z3J2
TAPLEFLHITFQCFF	NOD2	596	Q9HC29
LLCNPEFTFFSRADF	STAG3	651	Q9UJ98
FRDAFSLQCLASFLF	SLC4A10	501	Q6U841
AFAIPALCVVFSSFL	XKR4	486	Q5GH76
LPALAFAFFSLCFLG	SRD5A2	211	P31213
IVFLAFAFSALFISP	TMEM165	306	Q9HC07
LTSFLCPGIVFADFF	TM9SF2	436	Q99805
CFALSSFLSFLAIIP	SLC46A2	441	Q9BY10
VLLVFFSGLFFAFPC	ZDHHC19	36	Q8WVZ1
FIFLLFFPSFTGVLC	TMC5	836	Q6UXY8
SFLIICAAPFASHFL	TMEM182	131	Q6ZP80