Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor	QSOX1 QSOX2 SUMF1	1.52e-06	11	43	3	GO:0016670
GeneOntologyMolecularFunction	flavin-dependent sulfhydryl oxidase activity	QSOX1 QSOX2	1.36e-05	3	43	2	GO:0016971
GeneOntologyMolecularFunction	histone H3K4me/H3K4me2/H3K4me3 demethylase activity	KDM5B KDM5A	6.76e-05	6	43	2	GO:0034647
GeneOntologyMolecularFunction	netrin receptor activity	UNC5D UNC5B	6.76e-05	6	43	2	GO:0005042
GeneOntologyMolecularFunction	thiol oxidase activity	QSOX1 QSOX2	6.76e-05	6	43	2	GO:0016972
GeneOntologyMolecularFunction	cysteine-type deubiquitinase activity	USP44 USP34 USP16 ZRANB1	1.05e-04	114	43	4	GO:0004843
GeneOntologyMolecularFunction	histone H3K4 demethylase activity	KDM5B KDM5A	1.26e-04	8	43	2	GO:0032453
GeneOntologyMolecularFunction	deubiquitinase activity	USP44 USP34 USP16 ZRANB1	1.45e-04	124	43	4	GO:0101005
GeneOntologyMolecularFunction	ubiquitin-like protein peptidase activity	USP44 USP34 USP16 ZRANB1	2.13e-04	137	43	4	GO:0019783
GeneOntologyMolecularFunction	oxidoreductase activity, acting on a sulfur group of donors	QSOX1 QSOX2 SUMF1	2.51e-04	57	43	3	GO:0016667
GeneOntologyMolecularFunction	cysteine-type peptidase activity	USP44 USP34 USP16 ZRANB1	7.63e-04	192	43	4	GO:0008234
GeneOntologyMolecularFunction	intramolecular oxidoreductase activity, transposing S-S bonds	QSOX1 QSOX2	1.02e-03	22	43	2	GO:0016864
GeneOntologyMolecularFunction	protein disulfide isomerase activity	QSOX1 QSOX2	1.02e-03	22	43	2	GO:0003756
GeneOntologyMolecularFunction	histone H3 demethylase activity	KDM5B KDM5A	1.65e-03	28	43	2	GO:0141052
GeneOntologyMolecularFunction	histone demethylase activity	KDM5B KDM5A	2.02e-03	31	43	2	GO:0032452
GeneOntologyMolecularFunction	protein demethylase activity	KDM5B KDM5A	2.16e-03	32	43	2	GO:0140457
GeneOntologyMolecularFunction	peptidase activity	USP44 USP34 ADAMTS13 ADAMTS7 USP16 ZRANB1	2.62e-03	654	43	6	GO:0008233
GeneOntologyMolecularFunction	protein-disulfide reductase activity	QSOX1 QSOX2	2.72e-03	36	43	2	GO:0015035
GeneOntologyMolecularFunction	disulfide oxidoreductase activity	QSOX1 QSOX2	3.87e-03	43	43	2	GO:0015036
GeneOntologyMolecularFunction	demethylase activity	KDM5B KDM5A	4.05e-03	44	43	2	GO:0032451
GeneOntologyMolecularFunction	intramolecular oxidoreductase activity	QSOX1 QSOX2	6.71e-03	57	43	2	GO:0016860
GeneOntologyMolecularFunction	2-oxoglutarate-dependent dioxygenase activity	KDM5B KDM5A	8.65e-03	65	43	2	GO:0016706
GeneOntologyCellularComponent	endoplasmic reticulum lumen	QSOX1 ADAMTS13 ADAMTS7 ADAMTSL4 SPON1 SUMF1	6.51e-05	332	44	6	GO:0005788
Domain	TSP_1	ADAMTS13 C6 THSD7B ADAMTS7 ADAMTSL4 UNC5D UNC5B SPON1	1.14e-12	63	42	8	PF00090
Domain	TSP1	ADAMTS13 C6 THSD7B ADAMTS7 ADAMTSL4 UNC5D UNC5B SPON1	1.48e-12	65	42	8	SM00209
Domain	TSP1_rpt	ADAMTS13 C6 THSD7B ADAMTS7 ADAMTSL4 UNC5D UNC5B SPON1	1.48e-12	65	42	8	IPR000884
Domain	TSP1	ADAMTS13 C6 THSD7B ADAMTS7 ADAMTSL4 UNC5D UNC5B SPON1	1.48e-12	65	42	8	PS50092
Domain	Evr1_Alr	QSOX1 QSOX2	1.48e-05	3	42	2	PF04777
Domain	ERV/ALR_sulphydryl_oxidase	QSOX1 QSOX2	1.48e-05	3	42	2	IPR017905
Domain	-	QSOX1 QSOX2	1.48e-05	3	42	2	1.20.120.310
Domain	ERV_ALR	QSOX1 QSOX2	1.48e-05	3	42	2	PS51324
Domain	Lys_sp_deMease-like_dom	KDM5B KDM5A	2.95e-05	4	42	2	IPR013637
Domain	PLU-1	KDM5B KDM5A	2.95e-05	4	42	2	PF08429
Domain	zf-C5HC2	KDM5B KDM5A	4.92e-05	5	42	2	PF02928
Domain	UPA	UNC5D UNC5B	4.92e-05	5	42	2	PF17217
Domain	UPA	UNC5D UNC5B	4.92e-05	5	42	2	IPR033772
Domain	Znf_C5HC2	KDM5B KDM5A	4.92e-05	5	42	2	IPR004198
Domain	ZU5	UNC5D UNC5B	1.76e-04	9	42	2	SM00218
Domain	JmjN	KDM5B KDM5A	2.20e-04	10	42	2	PF02375
Domain	JmjN	KDM5B KDM5A	2.20e-04	10	42	2	SM00545
Domain	JMJN	KDM5B KDM5A	2.20e-04	10	42	2	PS51183
Domain	JmjN	KDM5B KDM5A	2.20e-04	10	42	2	IPR003349
Domain	ZU5	UNC5D UNC5B	2.20e-04	10	42	2	PS51145
Domain	ZnF_UBP	USP44 USP16	2.68e-04	11	42	2	SM00290
Domain	ZU5_dom	UNC5D UNC5B	3.21e-04	12	42	2	IPR000906
Domain	ZU5	UNC5D UNC5B	3.21e-04	12	42	2	PF00791
Domain	USP_CS	USP44 USP34 USP16	4.38e-04	66	42	3	IPR018200
Domain	zf-UBP	USP44 USP16	4.42e-04	14	42	2	PF02148
Domain	ZF_UBP	USP44 USP16	4.42e-04	14	42	2	PS50271
Domain	Znf_UBP	USP44 USP16	4.42e-04	14	42	2	IPR001607
Domain	-	KDM5B KDM5A	5.09e-04	15	42	2	1.10.150.60
Domain	ARID	KDM5B KDM5A	5.09e-04	15	42	2	PF01388
Domain	BRIGHT	KDM5B KDM5A	5.09e-04	15	42	2	SM00501
Domain	ARID_dom	KDM5B KDM5A	5.09e-04	15	42	2	IPR001606
Domain	ARID	KDM5B KDM5A	5.09e-04	15	42	2	PS51011
Domain	USP_1	USP44 USP34 USP16	5.21e-04	70	42	3	PS00972
Domain	UCH	USP44 USP34 USP16	5.43e-04	71	42	3	PF00443
Domain	USP_2	USP44 USP34 USP16	5.43e-04	71	42	3	PS00973
Domain	USP_3	USP44 USP34 USP16	5.66e-04	72	42	3	PS50235
Domain	USP_dom	USP44 USP34 USP16	5.66e-04	72	42	3	IPR028889
Domain	Peptidase_C19_UCH	USP44 USP34 USP16	5.66e-04	72	42	3	IPR001394
Domain	CTCK_1	MUC5AC SLIT3	7.38e-04	18	42	2	PS01185
Domain	PLAC	ADAMTS7 ADAMTSL4	8.24e-04	19	42	2	IPR010909
Domain	PLAC	ADAMTS7 ADAMTSL4	8.24e-04	19	42	2	PS50900
Domain	CT	MUC5AC SLIT3	1.11e-03	22	42	2	SM00041
Domain	ADAM_spacer1	ADAMTS7 ADAMTSL4	1.21e-03	23	42	2	IPR010294
Domain	ADAM_spacer1	ADAMTS7 ADAMTSL4	1.21e-03	23	42	2	PF05986
Domain	JmjC	KDM5B KDM5A	1.32e-03	24	42	2	PF02373
Domain	Peptidase_M12B_ADAM-TS	ADAMTS13 ADAMTS7	1.32e-03	24	42	2	IPR013273
Domain	Cys_knot_C	MUC5AC SLIT3	1.43e-03	25	42	2	IPR006207
Domain	CTCK_2	MUC5AC SLIT3	1.43e-03	25	42	2	PS01225
Domain	DEATH	UNC5D UNC5B	1.67e-03	27	42	2	SM00005
Domain	Thioredoxin	QSOX1 QSOX2	2.20e-03	31	42	2	PF00085
Domain	LRRCT	TLR7 SLIT3	2.35e-03	32	42	2	PF01463
Domain	JMJC	KDM5B KDM5A	2.35e-03	32	42	2	PS51184
Domain	JmjC_dom	KDM5B KDM5A	2.35e-03	32	42	2	IPR003347
Domain	JmjC	KDM5B KDM5A	2.49e-03	33	42	2	SM00558
Domain	Death	UNC5D UNC5B	2.49e-03	33	42	2	PF00531
Domain	Death_domain	UNC5D UNC5B	3.30e-03	38	42	2	IPR000488
Domain	DEATH_DOMAIN	UNC5D UNC5B	3.30e-03	38	42	2	PS50017
Domain	DISINTEGRIN_1	ADAMTS13 ADAMTS7	3.65e-03	40	42	2	PS00427
Domain	ADAM_MEPRO	ADAMTS13 ADAMTS7	3.65e-03	40	42	2	PS50215
Domain	DISINTEGRIN_2	ADAMTS13 ADAMTS7	3.65e-03	40	42	2	PS50214
Domain	Reprolysin	ADAMTS13 ADAMTS7	3.65e-03	40	42	2	PF01421
Domain	Peptidase_M12B	ADAMTS13 ADAMTS7	3.65e-03	40	42	2	IPR001590
Domain	Thioredoxin_domain	QSOX1 QSOX2	3.83e-03	41	42	2	IPR013766
Domain	Disintegrin_dom	ADAMTS13 ADAMTS7	3.83e-03	41	42	2	IPR001762
Domain	THIOREDOXIN_2	QSOX1 QSOX2	4.20e-03	43	42	2	PS51352
Domain	Pept_M10_metallopeptidase	ADAMTS13 ADAMTS7	4.20e-03	43	42	2	IPR001818
Domain	PMP22/EMP/MP20/Claudin	EMP3 TMEM178A	4.60e-03	45	42	2	IPR004031
Pathway	REACTOME_DISEASES_ASSOCIATED_WITH_O_GLYCOSYLATION_OF_PROTEINS	ADAMTS13 THSD7B ADAMTS7 MUC5AC ADAMTSL4 SPON1	1.22e-08	68	34	6	M27303
Pathway	REACTOME_O_GLYCOSYLATION_OF_TSR_DOMAIN_CONTAINING_PROTEINS	ADAMTS13 THSD7B ADAMTS7 ADAMTSL4 SPON1	3.26e-08	39	34	5	M27417
Pathway	REACTOME_O_GLYCOSYLATION_OF_TSR_DOMAIN_CONTAINING_PROTEINS	ADAMTS13 THSD7B ADAMTS7 ADAMTSL4 SPON1	3.26e-08	39	34	5	MM15165
Pathway	REACTOME_DISEASES_OF_GLYCOSYLATION	ADAMTS13 THSD7B ADAMTS7 MUC5AC ADAMTSL4 SPON1 DOLK	4.08e-08	143	34	7	M27275
Pathway	REACTOME_DISEASES_OF_METABOLISM	ADAMTS13 THSD7B ADAMTS7 MUC5AC ADAMTSL4 SLC37A4 SPON1 DOLK	1.07e-07	250	34	8	M27554
Pathway	REACTOME_O_LINKED_GLYCOSYLATION	ADAMTS13 THSD7B ADAMTS7 MUC5AC ADAMTSL4 SPON1	2.10e-07	109	34	6	MM15164
Pathway	REACTOME_POST_TRANSLATIONAL_PROTEIN_MODIFICATION	USP44 USP34 QSOX1 ADAMTS13 THSD7B ADAMTS7 USP16 MUC5AC ADAMTSL4 ZRANB1 FOLR2 DCAF4L1 SPON1 SUMF1 DOLK	2.26e-07	1389	34	15	MM15307
Pathway	REACTOME_O_LINKED_GLYCOSYLATION	ADAMTS13 THSD7B ADAMTS7 MUC5AC ADAMTSL4 SPON1	2.34e-07	111	34	6	M27416
Pathway	REACTOME_POST_TRANSLATIONAL_PROTEIN_MODIFICATION	USP44 USP34 QSOX1 ADAMTS13 THSD7B ADAMTS7 USP16 MUC5AC ADAMTSL4 ZRANB1 FOLR2 SPON1 SUMF1 DOLK	3.27e-06	1475	34	14	M19806
Pathway	REACTOME_NETRIN_MEDIATED_REPULSION_SIGNALS	UNC5D UNC5B	1.57e-04	8	34	2	M27328
Pathway	REACTOME_NETRIN_1_SIGNALING	UNC5D UNC5B SLIT3	1.59e-04	44	34	3	M875
Pubmed	O-fucosylation of thrombospondin type 1 repeats restricts epithelial to mesenchymal transition (EMT) and maintains epiblast pluripotency during mouse gastrulation.	ADAMTS13 C6 THSD7B ADAMTS7 ADAMTSL4 SPON1	6.25e-10	75	45	6	20637190
Pubmed	The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.	QSOX1 TLR7 ADAMTS13 PGAP3 ADAMTSL4 TMEM178A UNC5D UNC5B SUMF1 SLIT3 DOLK	3.74e-08	985	45	11	12975309
Pubmed	KDM5A and KDM5B histone-demethylases contribute to HU-induced replication stress response and tolerance.	KDM5B KDM5A	1.64e-06	2	45	2	34184733
Pubmed	Drawing a line between histone demethylase KDM5A and KDM5B: their roles in development and tumorigenesis.	KDM5B KDM5A	1.64e-06	2	45	2	36509829
Pubmed	Mouse quiescin sulfhydryl oxidases exhibit distinct epididymal luminal distribution with segment-specific sperm surface associations.	QSOX1 QSOX2	1.64e-06	2	45	2	29800099
Pubmed	Sulfhydryl oxidases: emerging catalysts of protein disulfide bond formation in eukaryotes.	QSOX1 QSOX2	1.64e-06	2	45	2	12176051
Pubmed	KDM5 Histone Demethylase Activity Links Cellular Transcriptomic Heterogeneity to Therapeutic Resistance.	KDM5B KDM5A	1.64e-06	2	45	2	30472020
Pubmed	KDM5 lysine demethylases are involved in maintenance of 3'UTR length.	KDM5B KDM5A	1.64e-06	2	45	2	28138513
Pubmed	Human and mouse proteases: a comparative genomic approach.	USP44 USP34 USP16 ZRANB1	3.78e-06	81	45	4	12838346
Pubmed	Experimental validation of 5 in-silico predicted glioma biomarkers.	SPON1 SLIT3	4.91e-06	3	45	2	24158112
Pubmed	Histone demethylase KDM5 regulates cardiomyocyte maturation by promoting fatty acid oxidation, oxidative phosphorylation, and myofibrillar organization.	KDM5B KDM5A	4.91e-06	3	45	2	38230606
Pubmed	Re-expression of the retinoblastoma-binding protein 2-homolog 1 reveals tumor-suppressive functions in highly metastatic melanoma cells.	KDM5B KDM5A	4.91e-06	3	45	2	16645588
Pubmed	Characterization of a Linked Jumonji Domain of the KDM5/JARID1 Family of Histone H3 Lysine 4 Demethylases.	KDM5B KDM5A	4.91e-06	3	45	2	26645689
Pubmed	Novel JARID1C/SMCX mutations in patients with X-linked mental retardation.	KDM5B KDM5A	9.81e-06	4	45	2	16541399
Pubmed	H3K4 demethylation by Jarid1a and Jarid1b contributes to retinoblastoma-mediated gene silencing during cellular senescence.	KDM5B KDM5A	9.81e-06	4	45	2	22615382
Pubmed	Structural Basis of Latrophilin-FLRT-UNC5 Interaction in Cell Adhesion.	UNC5D UNC5B	9.81e-06	4	45	2	26235030
Pubmed	Histone lysine demethylase JARID1a activates CLOCK-BMAL1 and influences the circadian clock.	KDM5B KDM5A	2.45e-05	6	45	2	21960634
Pubmed	Cloning of three mouse Unc5 genes and their expression patterns at mid-gestation.	UNC5D UNC5B	3.42e-05	7	45	2	12351186
Pubmed	DNA-binding properties of ARID family proteins.	KDM5B KDM5A	3.42e-05	7	45	2	15640446
Pubmed	Peri-pubertal emergence of UNC-5 homologue expression by dopamine neurons in rodents.	UNC5D UNC5B	3.42e-05	7	45	2	20628609
Pubmed	FLRT structure: balancing repulsion and cell adhesion in cortical and vascular development.	UNC5D UNC5B	3.42e-05	7	45	2	25374360
Pubmed	Spurious transcription causing innate immune responses is prevented by 5-hydroxymethylcytosine.	TLR7 MUC5AC	4.56e-05	8	45	2	36539616
Pubmed	Retinal ganglion cell axon guidance in the mouse optic chiasm: expression and function of robos and slits.	FUT4 SLIT3	5.86e-05	9	45	2	10864955
Pubmed	ZRANB1 Is an EZH2 Deubiquitinase and a Potential Therapeutic Target in Breast Cancer.	USP44 ZRANB1	5.86e-05	9	45	2	29669287
Pubmed	Spatiotemporal expression of repulsive guidance molecules (RGMs) and their receptor neogenin in the mouse brain.	UNC5D UNC5B	5.86e-05	9	45	2	23457482
Pubmed	ADAMTS: a novel family of extracellular matrix proteases.	ADAMTS13 ADAMTS7	7.32e-05	10	45	2	11167130
Pubmed	Novel role for Netrins in regulating epithelial behavior during lung branching morphogenesis.	UNC5D UNC5B	8.94e-05	11	45	2	15186747
Pubmed	Analysis of Netrin 1 receptors during inner ear development.	UNC5D UNC5B	8.94e-05	11	45	2	17616930
Pubmed	Widespread Differential Expression of Coding Region and 3' UTR Sequences in Neurons and Other Tissues.	UNC5D UNC5B	1.07e-04	12	45	2	26687222
Pubmed	Insights on ADAMTS proteases and ADAMTS-like proteins from mammalian genetics.	ADAMTS13 ADAMTS7	1.07e-04	12	45	2	25770910
Pubmed	FLRT2 and FLRT3 act as repulsive guidance cues for Unc5-positive neurons.	UNC5D UNC5B	1.07e-04	12	45	2	21673655
Pubmed	Dynamic patterns of histone H3 lysine 4 methyltransferases and demethylases during mouse preimplantation development.	KDM5B KDM5A	1.27e-04	13	45	2	24619213
Pubmed	Expression patterns of two murine homologs of Drosophila single-minded suggest possible roles in embryonic patterning and in the pathogenesis of Down syndrome.	TIAM1 SPON1	1.27e-04	13	45	2	8812055
Pubmed	FLRT2 and FLRT3 Cooperate in Maintaining the Tangential Migratory Streams of Cortical Interneurons during Development.	UNC5D UNC5B	1.70e-04	15	45	2	34301831
Pubmed	Ezh2 orchestrates topographic migration and connectivity of mouse precerebellar neurons.	UNC5B SLIT3	2.76e-04	19	45	2	23307742
Pubmed	Extracellular matrix secretion by cardiac fibroblasts: role of microRNA-29b and microRNA-30c.	QSOX1 ADAMTS7 ADAMTSL4 SLIT3	2.99e-04	248	45	4	24006456
Pubmed	FOXG1 Orchestrates Neocortical Organization and Cortico-Cortical Connections.	UNC5D SLIT3	3.06e-04	20	45	2	30392794
Pubmed	The histone demethylase Jarid1b ensures faithful mouse development by protecting developmental genes from aberrant H3K4me3.	KDM5B KDM5A	3.06e-04	20	45	2	23637629
Pubmed	A mouse knockout library for secreted and transmembrane proteins.	TLR7 PGAP3 TMEM178A SUMF1 DOLK	3.13e-04	460	45	5	20562862
Pubmed	Broad histone H3K4me3 domains in mouse oocytes modulate maternal-to-zygotic transition.	KDM5B KDM5A	3.38e-04	21	45	2	27626377
Pubmed	Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.	QSOX1 ADAMTS13 C6 ADAMTSL4	3.42e-04	257	45	4	16335952
Pubmed	Usp12 stabilizes the T-cell receptor complex at the cell surface during signaling.	USP44 USP34	3.72e-04	22	45	2	26811477
Pubmed	Dynamic FoxG1 expression coordinates the integration of multipolar pyramidal neuron precursors into the cortical plate.	UNC5D UNC5B	3.72e-04	22	45	2	22726835
Pubmed	Cloning and enzymatic analysis of 22 novel human ubiquitin-specific proteases.	USP44 USP34	4.07e-04	23	45	2	14715245
Pubmed	Synergistic integration of Netrin and ephrin axon guidance signals by spinal motor neurons.	UNC5D UNC5B	4.44e-04	24	45	2	26633881
Pubmed	Ezh2 represses the basal cell lineage during lung endoderm development.	FUT4 MUC5AC	4.44e-04	24	45	2	25516972
Pubmed	Mutagenesis of diploid mammalian genes by gene entrapment.	DPYS CTC1 FOLR2	5.76e-04	125	45	3	17062627
Pubmed	Fezl regulates the differentiation and axon targeting of layer 5 subcortical projection neurons in cerebral cortex.	UNC5D UNC5B SLIT3	5.89e-04	126	45	3	16284245
Pubmed	Molecular signatures and cellular diversity during mouse habenula development.	UNC5D SPON1	6.06e-04	28	45	2	35793630
Pubmed	Sequential genome-wide CRISPR-Cas9 screens identify genes regulating cell-surface expression of tetraspanins.	USP34 TLR7 CTC1 TMEM178A FOLR2 QSOX2	6.77e-04	832	45	6	36724073
Pubmed	Remotely Produced and Axon-Derived Netrin-1 Instructs GABAergic Neuron Migration and Dopaminergic Substantia Nigra Development.	UNC5D UNC5B	6.96e-04	30	45	2	32562661
Pubmed	Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci.	ZRANB1 QSOX2 SLIT3	7.36e-04	136	45	3	25429064
Pubmed	Distinct expression of select and transcriptome-wide isolated 3'UTRs suggests critical roles in development and transition states.	UNC5D UNC5B	8.43e-04	33	45	2	33951080
Pubmed	Multiplexed barcoded CRISPR-Cas9 screening enabled by CombiGEM.	KDM5B KDM5A	8.43e-04	33	45	2	26864203
Pubmed	The loss of Hoxa5 function promotes Notch-dependent goblet cell metaplasia in lung airways.	FUT4 MUC5AC	8.43e-04	33	45	2	23213461
Pubmed	Postmitotic Hoxa5 Expression Specifies Pontine Neuron Positional Identity and Input Connectivity of Cortical Afferent Subsets.	UNC5B SLIT3	8.94e-04	34	45	2	32553152
Cytoband	Xp22.3	TLR7 CLCN4 IL3RA	1.54e-06	23	45	3	Xp22.3
Cytoband	21q22.11	TIAM1 USP16	1.71e-03	62	45	2	21q22.11
Cytoband	Ensembl 112 genes in cytogenetic band chrXp22	TLR7 CLCN4 IL3RA	1.91e-03	250	45	3	chrXp22
GeneFamily	Ubiquitin specific peptidases	USP44 USP34 USP16	6.96e-05	56	26	3	366
GeneFamily	AT-rich interaction domain containing	KDM5B KDM5A	2.06e-04	15	26	2	418
GeneFamily	ADAM metallopeptidases with thrombospondin type 1 motif	ADAMTS13 ADAMTS7	3.35e-04	19	26	2	50
GeneFamily	PHD finger proteins\|Lysine demethylases	KDM5B KDM5A	5.38e-04	24	26	2	485
GeneFamily	PHD finger proteins	KDM5B KDM5A	7.37e-03	90	26	2	88
ToppCell	Globus_pallidus-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Sphkap-Excitatory_Neuron.Gad1Gad2.Sphkap-Tmem255a_(Basomedial_amygdaloid_nucleus_(BMA))\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	ADAMTS13 DCST1 MUC5AC	2.11e-05	53	45	3	db4c0ec659fb1f3196aef6f989f27b25f710c551
ToppCell	Globus_pallidus-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Sphkap-Excitatory_Neuron.Gad1Gad2.Sphkap-Tmem255a_(Basomedial_amygdaloid_nucleus_(BMA))-\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	ADAMTS13 DCST1 MUC5AC	2.11e-05	53	45	3	b2b5f47ab9012f08821f2a5f0be24847b5196094
ToppCell	facs-Liver-Non-hepatocytes-3m-Myeloid-nan\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TLR7 C6 LARS2 FOLR2	2.54e-05	169	45	4	0f5e737b265ba333275a0cd289dab029a1542075
ToppCell	Frontal_cortex-Neuronal-Excitatory-eN1(Slc17a7)-eN1_2-Nptxr-Excitatory_Neuron.Slc17a7.Nptxr-Drd1_(Deep_layer_pyramidal_cells)\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	KDM5A FOLR2 SLC37A4 QSOX2	2.97e-05	176	45	4	3c76a5c4ca2b378667cb155fbb9675519572b35d
ToppCell	3'-Pediatric_IBD-SmallIntestine-Mesenchymal-fibroblastic-Stromal_3_(C7+)\|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract	DPYS C6 ADAMTSL4 SLIT3	3.18e-05	179	45	4	dcd0a83f0592ae27f814d064b4791f84c3c86e64
ToppCell	COVID-19-kidney-tDL\|COVID-19 / Disease (COVID-19 only), tissue and cell type	GLYATL1 ADORA2A-AS1 DPYS UNC5D	3.25e-05	180	45	4	864c895b5eaedefae86f5829fa344f7b686fb59f
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-3m\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TIAM1 LARS2 TMEM178A UNC5D	3.61e-05	185	45	4	cdd75abdaa1ecedfd2e636203b83a6ac1782f0c3
ToppCell	TCGA-Kidney-Primary_Tumor-Renal_Cell_Carcinoma-Kidney_Clear_Cell_Renal_Carcinoma-2\|TCGA-Kidney / Sample_Type by Project: Shred V9	GPR161 IL3RA UNC5B SLIT3	3.69e-05	186	45	4	1e6526fc9e9381b7ace864588cc7bd80194338d6
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	GLYATL1 ADORA2A-AS1 DPYS UNC5D	3.93e-05	189	45	4	13fd07cc408a9486f61a7b2c3a132c52d14b438d
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	GLYATL1 ADORA2A-AS1 DPYS UNC5D	3.93e-05	189	45	4	204ab61ae606b2d9be0cb6bf6a83a011740693a8
ToppCell	droplet-Liver-LIVER-NPC-1m-Mesenchymal-hepatic_stellate_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADAMTS13 ADAMTSL4 TMEM178A UNC5B	4.35e-05	194	45	4	415801a3dfacf05f2b603fb424df3d045190a812
ToppCell	droplet-Liver-LIVER-NPC-1m-Mesenchymal-hepatic_stellate_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADAMTS13 ADAMTSL4 TMEM178A UNC5B	4.35e-05	194	45	4	256cb33ec90328f2704921fb0fe0fd9812e138b0
ToppCell	droplet-Liver-LIVER-NPC-1m-Mesenchymal\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADAMTS13 ADAMTSL4 TMEM178A UNC5B	4.35e-05	194	45	4	7942bc83c1bdca687795b91aa232824d603f9b09
ToppCell	normal_Lung-Epithelial_cells-Undetermined\|Epithelial_cells / Location, Cell class and cell subclass	TLR7 EMP3 IL3RA ADAMTSL4	4.44e-05	195	45	4	31710a593d503e46acad1db38adacace4d863388
ToppCell	BAL-Severe-cDC_0\|Severe / Compartment, Disease Groups and Clusters	IL3RA ADAMTSL4 FOLR2 UNC5B	4.80e-05	199	45	4	d39be8b173156bf87baddd3caed4b35597c53ea1
Disease	syndromic X-linked intellectual disability Claes-Jensen type (implicated_via_orthology)	KDM5B KDM5A	1.30e-05	4	44	2	DOID:0060809 (implicated_via_orthology)
Disease	syndromic intellectual disability (implicated_via_orthology)	KDM5B KDM5A	2.57e-04	16	44	2	DOID:0050888 (implicated_via_orthology)
Disease	sex interaction measurement, Crohn's disease	USP34 PGAP3	1.40e-03	37	44	2	EFO_0000384, EFO_0008343
Disease	personality trait	ZNF229 TMEM178A	1.55e-03	39	44	2	EFO_0004365
Disease	Microcalcification	C6 CTC1	1.80e-03	42	44	2	C0521174
Disease	Calcinosis	C6 CTC1	1.80e-03	42	44	2	C0006663

Protein segments in the cluster

Peptide	Gene	Start	Entry
CTTAWFHSDWSSKCS	ADAMTSL4	841	Q6UY14
CCSHLSWSSSAYQAW	CTC1	81	Q2NKJ3
CCWVLLALTWHTSAY	CASR	6	P41180
CSHTWDWRFSCTQQA	ADORA2A-AS1	61	P86434
AFWYSHEQCCWTSNE	CLCN4	106	P51793
DCTYRWHVGTWMECS	ADAMTS13	1071	Q76LX8
CLSWYTSSWRECSEA	ADAMTS7	1521	Q9UKP4
WAVEFFASWCGHCIA	QSOX1	61	O00391
AWLVQFYSSWCGHCI	QSOX2	81	Q6ZRP7
VLSIHATVWDRYSWC	DOLK	31	Q9UPQ8
SYAVHITSFWDEPWC	FUT4	491	P22083
CCDYSLHVAVTWWSD	DPYS	126	Q14117
WSCAWSLNTRAYHCF	DCAF4L1	186	Q3SXM0
GFFEASCEWHQWTCY	GLYATL1	281	Q969I3
MCFSSFCWHIEDHWS	KDM5B	491	Q9UGL1
CHPRCTWTTWFDVDF	MUC5AC	2116	P98088
CFSSFCWHIEDHWSY	KDM5A	476	P29375
YSWSTAFWVAEVICA	SLC37A4	391	O43826
TCWIHDVDFLSCSWA	IL3RA	111	P26951
ACFCDHYAWTQWTSC	C6	21	P13671
HYAWTQWTSCSKTCN	C6	26	P13671
RTLDCEAVYCWSCWD	DCST1	661	Q5T197
EDCQRWWEDCHTSHT	FOLR2	131	P14207
SQAYHWCFSKDWDVT	MARF1	1201	Q9Y4F3
ETWATWLSFASAVCH	GPR161	306	Q8N6U8
YDCTWNNDTKTWACS	EMP3	41	P54852
HTCVYTWVKQCWSVA	C5orf34	231	Q96MH7
YHTCVAFAWVSLNAW	PGAP3	136	Q96FM1
ICHTGSEARWTTTWY	C8orf17	26	Q9NRJ1
ETCIYSNWSPWSACS	SPON1	441	Q9HCB6
CAHYTWDASVLLQAW	LARS2	811	Q15031
EDWLAVHCCWAFSIC	PLAC8L1	136	A1L4L8
EHGYSWSIFCAWCSL	TMEM178A	251	Q8NBL3
VLHVSWNDAVAYCTW	SUMF1	206	Q8NBK3
HLYCDCHLAWLSDWL	SLIT3	216	O75094
VDRQFACSSCDHVWW	SHFL	106	Q9NUL5
VLSLDNWSVWCYVCD	USP16	106	Q9Y5T5
CDIWVHEYFTPSWFC	TIAM1	756	Q13009
FGLEDYWCQCVAWSS	UNC5B	121	Q8IZJ1
TEWSKWSACSTECAH	UNC5B	306	Q8IZJ1
DYWCQCVAWSHLGTS	UNC5D	131	Q6UXZ4
LCTCDAVWFVWWVNH	TLR7	786	Q9NYK1
NWDDDSFCWISCHVD	ZNF229	216	Q9UJW7
SHYSMWLLVSWAHCC	USP34	1626	Q70CQ2
ECNQYSWVVEHWSSC	THSD7B	1056	Q9C0I4
KWHCVDCNTTESIWA	USP44	26	Q9H0E7
QHWTCSVCTYENWAK	ZRANB1	151	Q9UGI0
SLHFCLCWPSVYWTE	THEG	161	Q9P2T0