Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	insulin-like growth factor II binding	IGFBP3 IGFBP4	3.86e-05	8	24	2	GO:0031995
GeneOntologyMolecularFunction	insulin-like growth factor I binding	IGFBP3 IGFBP4	1.07e-04	13	24	2	GO:0031994
GeneOntologyMolecularFunction	diacylglycerol-dependent serine/threonine kinase activity	PRKCE PRKCI	1.64e-04	16	24	2	GO:0004697
GeneOntologyMolecularFunction	insulin-like growth factor binding	IGFBP3 IGFBP4	2.34e-04	19	24	2	GO:0005520
Domain	Growth_fac_rcpt_	FBN2 IGFBP3 IGFBP4 RSPO1 EGFL6	1.43e-06	156	24	5	IPR009030
Domain	DAG/PE-bd	PRKCE PRKCI RASGRP3	2.44e-06	21	24	3	IPR020454
Domain	IGFBP1-6	IGFBP3 IGFBP4	2.37e-05	6	24	2	IPR009168
Domain	IGFBP_1-6_chordata	IGFBP3 IGFBP4	2.37e-05	6	24	2	IPR022321
Domain	C1_1	PRKCE PRKCI RASGRP3	5.21e-05	57	24	3	PF00130
Domain	TSP_1	CFP ADAMTS6 RSPO1	7.04e-05	63	24	3	PF00090
Domain	ZF_DAG_PE_1	PRKCE PRKCI RASGRP3	7.38e-05	64	24	3	PS00479
Domain	ZF_DAG_PE_2	PRKCE PRKCI RASGRP3	7.38e-05	64	24	3	PS50081
Domain	C1	PRKCE PRKCI RASGRP3	7.73e-05	65	24	3	SM00109
Domain	TSP1	CFP ADAMTS6 RSPO1	7.73e-05	65	24	3	SM00209
Domain	TSP1_rpt	CFP ADAMTS6 RSPO1	7.73e-05	65	24	3	IPR000884
Domain	TSP1	CFP ADAMTS6 RSPO1	7.73e-05	65	24	3	PS50092
Domain	PE/DAG-bd	PRKCE PRKCI RASGRP3	8.09e-05	66	24	3	IPR002219
Domain	Insulin_GF-bd_Cys-rich_CS	IGFBP3 IGFBP4	8.64e-05	11	24	2	IPR017891
Domain	IGFBP_N_1	IGFBP3 IGFBP4	1.04e-04	12	24	2	PS00222
Domain	Thyroglobulin_1	IGFBP3 IGFBP4	2.13e-04	17	24	2	PF00086
Domain	TY	IGFBP3 IGFBP4	2.13e-04	17	24	2	SM00211
Domain	-	IGFBP3 IGFBP4	2.13e-04	17	24	2	4.10.800.10
Domain	THYROGLOBULIN_1_1	IGFBP3 IGFBP4	2.13e-04	17	24	2	PS00484
Domain	THYROGLOBULIN_1_2	IGFBP3 IGFBP4	2.13e-04	17	24	2	PS51162
Domain	Thyroglobulin_1	IGFBP3 IGFBP4	2.13e-04	17	24	2	IPR000716
Domain	IB	IGFBP3 IGFBP4	2.39e-04	18	24	2	SM00121
Domain	IGFBP_N_2	IGFBP3 IGFBP4	2.96e-04	20	24	2	PS51323
Domain	IGFBP-like	IGFBP3 IGFBP4	2.96e-04	20	24	2	IPR000867
Domain	IGFBP	IGFBP3 IGFBP4	2.96e-04	20	24	2	PF00219
Domain	Pkinase_C	PRKCE PRKCI	1.03e-03	37	24	2	IPR017892
Domain	Pkinase_C	PRKCE PRKCI	1.32e-03	42	24	2	PF00433
Domain	AGC-kinase_C	PRKCE PRKCI	2.34e-03	56	24	2	IPR000961
Domain	AGC_KINASE_CTER	PRKCE PRKCI	2.34e-03	56	24	2	PS51285
Domain	S_TK_X	PRKCE PRKCI	2.34e-03	56	24	2	SM00133
Domain	EGF_CA	FBN2 EGFL6	5.42e-03	86	24	2	PF07645
Domain	EGF_Ca-bd_CS	FBN2 EGFL6	6.84e-03	97	24	2	IPR018097
Domain	EGF_CA	FBN2 EGFL6	7.12e-03	99	24	2	PS01187
Domain	ASX_HYDROXYL	FBN2 EGFL6	7.25e-03	100	24	2	PS00010
Domain	EGF-type_Asp/Asn_hydroxyl_site	FBN2 EGFL6	8.12e-03	106	24	2	IPR000152
Domain	EGF_CA	FBN2 EGFL6	1.06e-02	122	24	2	SM00179
Domain	EGF-like_Ca-bd_dom	FBN2 EGFL6	1.10e-02	124	24	2	IPR001881
Pathway	BIOCARTA_GHRELIN_PATHWAY	IGFBP3 IGFBP4	9.35e-05	13	16	2	M22016
Pathway	PID_WNT_SIGNALING_PATHWAY	IGFBP4 RSPO1	4.49e-04	28	16	2	M77
Pathway	PID_RAS_PATHWAY	PRKCE RASGRP3	5.16e-04	30	16	2	M269
Pathway	WP_FACTORS_AND_PATHWAYS_AFFECTING_INSULINLIKE_GROWTH_FACTOR_IGF1AKT_SIGNALING	IGFBP3 IGFBP4	5.51e-04	31	16	2	MM15818
Pathway	WP_MYOMETRIAL_RELAXATION_AND_CONTRACTION_PATHWAYS	PRKCE IGFBP3 IGFBP4	6.45e-04	154	16	3	MM15974
Pathway	WP_MYOMETRIAL_RELAXATION_AND_CONTRACTION_PATHWAYS	PRKCE IGFBP3 IGFBP4	6.70e-04	156	16	3	M39475
Pathway	REACTOME_O_GLYCOSYLATION_OF_TSR_DOMAIN_CONTAINING_PROTEINS	CFP ADAMTS6	8.73e-04	39	16	2	M27417
Pathway	REACTOME_O_GLYCOSYLATION_OF_TSR_DOMAIN_CONTAINING_PROTEINS	CFP ADAMTS6	8.73e-04	39	16	2	MM15165
Pathway	WP_VEGFAVEGFR2_SIGNALING	PRKCE PRKCI IGFBP3 INPP5K	1.17e-03	431	16	4	M39729
Pathway	WP_CHRONIC_HYPERGLYCEMIA_IMPAIRMENT_OF_NEURON_FUNCTION	PRKCE PRKCI	1.21e-03	46	16	2	M46450
Pathway	WP_WNT_SIGNALING	PRKCE PRKCI	2.13e-03	61	16	2	MM15893
Pubmed	Acquired resistance to EGFR tyrosine kinase inhibitors in cancer cells is mediated by loss of IGF-binding proteins.	IGFBP3 IGFBP4	4.96e-07	2	25	2	18568074
Pubmed	Insulin-like growth factor-II (IGF-II), IGF-binding protein-3 (IGFBP-3), and IGFBP-4 in follicular fluid are associated with oocyte maturation and embryo development.	IGFBP3 IGFBP4	4.96e-07	2	25	2	17070193
Pubmed	IGF-binding protein mRNAs in the human fetus: tissue and cellular distribution of developmental expression.	IGFBP3 IGFBP4	4.96e-07	2	25	2	8964576
Pubmed	Heparin-binding EGF-like growth factor (HB-EGF) overexpression in transgenic mice downregulates insulin-like growth factor binding protein (IGFBP)-3 and -4 mRNA.	IGFBP3 IGFBP4	1.49e-06	3	25	2	16019424
Pubmed	Proteolysis of insulin-like growth factors (IGF) and IGF binding proteins by cathepsin D.	IGFBP3 IGFBP4	1.49e-06	3	25	2	9275067
Pubmed	Diminished growth and enhanced glucose metabolism in triple knockout mice containing mutations of insulin-like growth factor binding protein-3, -4, and -5.	IGFBP3 IGFBP4	1.49e-06	3	25	2	16675541
Pubmed	Association of IGF1 gene haplotypes with high myopia in Chinese adults.	IGFBP3 IGFBP4	1.49e-06	3	25	2	22332214
Pubmed	FOXL2 modulates cartilage, skeletal development and IGF1-dependent growth in mice.	FBN2 IGFBP3 IGFBP4	2.72e-06	38	25	3	26134413
Pubmed	Tissue-specific expression of the insulin-like growth factor binding protein (IGFBP) mRNAs in mouse and rat development.	IGFBP3 IGFBP4	2.97e-06	4	25	2	7505465
Pubmed	Insulin-like growth factor-binding proteins in serum and other biological fluids: regulation and functions.	IGFBP3 IGFBP4	2.97e-06	4	25	2	9408744
Pubmed	A new member of the third class in the protein kinase C family, PKC lambda, expressed dominantly in an undifferentiated mouse embryonal carcinoma cell line and also in many tissues and cells.	PRKCE PRKCI	4.95e-06	5	25	2	7513693
Pubmed	Impaired expression of insulin-like growth factor-1 system in skeletal muscle of amyotrophic lateral sclerosis patients.	IGFBP3 IGFBP4	4.95e-06	5	25	2	22246875
Pubmed	Delayed mammary gland involution in mice with mutation of the insulin-like growth factor binding protein 5 gene.	IGFBP3 IGFBP4	4.95e-06	5	25	2	17255210
Pubmed	Insulin-like growth factor binding proteins are transcribed by preimplantation mouse embryos.	IGFBP3 IGFBP4	7.43e-06	6	25	2	7511095
Pubmed	Gene expression of the six insulin-like growth factor binding proteins in the mouse conceptus during mid- and late gestation.	IGFBP3 IGFBP4	7.43e-06	6	25	2	7684980
Pubmed	Growth hormone deficiency in 'little' mice results in aberrant body composition, reduced insulin-like growth factor-I and insulin-like growth factor-binding protein-3 (IGFBP-3), but does not affect IGFBP-2, -1 or -4.	IGFBP3 IGFBP4	7.43e-06	6	25	2	7679139
Pubmed	Generation of antisera to mouse insulin-like growth factor binding proteins (IGFBP)-1 to -6: comparison of IGFBP protein and messenger ribonucleic acid localization in the mouse embryo.	IGFBP3 IGFBP4	7.43e-06	6	25	2	10579362
Pubmed	Deletion, but not antagonism, of the mouse growth hormone receptor results in severely decreased body weights, insulin, and insulin-like growth factor I levels and increased life span.	IGFBP3 IGFBP4	7.43e-06	6	25	2	12933651
Pubmed	Transgenic mouse models for studying the functions of insulin-like growth factor-binding proteins.	IGFBP3 IGFBP4	7.43e-06	6	25	2	10744620
Pubmed	Insulin-like growth factor (IGF)-binding proteins in serum--do they have additional roles besides modulating the endocrine IGF actions?	IGFBP3 IGFBP4	7.43e-06	6	25	2	8923818
Pubmed	PKCdelta associates with and is involved in the phosphorylation of RasGRP3 in response to phorbol esters.	PRKCE RASGRP3	7.43e-06	6	25	2	15213298
Pubmed	Altered messenger RNA and protein expressions for insulin-like growth factor family members in clear cell and papillary renal cell carcinomas.	IGFBP3 IGFBP4	7.43e-06	6	25	2	15661050
Pubmed	Simultaneous detection of multiple gene expression in mouse and human individual preimplantation embryos.	IGFBP3 IGFBP4	7.43e-06	6	25	2	9093203
Pubmed	Selective alterations in organ sizes in mice with a targeted disruption of the insulin-like growth factor binding protein-2 gene.	IGFBP3 IGFBP4	7.43e-06	6	25	2	10976924
Pubmed	cDNA cloning and mRNA expression of the six mouse insulin-like growth factor binding proteins.	IGFBP3 IGFBP4	7.43e-06	6	25	2	7529732
Pubmed	Regulation of metabolic water and protein compartments by insulin-like growth factor-I and testosterone in growth hormone-deficient lit/lit mice.	IGFBP3 IGFBP4	7.43e-06	6	25	2	7510770
Pubmed	Transferrin is an insulin-like growth factor-binding protein-3 binding protein.	IGFBP3 IGFBP4	1.04e-05	7	25	2	11297622
Pubmed	Role of IGFBPs in the morphogenesis of lingual papillae.	IGFBP3 IGFBP4	1.39e-05	8	25	2	16047381
Pubmed	The expression of insulin-like growth factor and insulin-like growth factor binding protein mRNAs in mouse placenta.	IGFBP3 IGFBP4	1.39e-05	8	25	2	16338473
Pubmed	An in situ hybridization study of the insulin-like growth factor system in developing condylar cartilage of the fetal mouse mandible.	IGFBP3 IGFBP4	1.39e-05	8	25	2	22688304
Pubmed	Biosensor measurement of the interaction kinetics between insulin-like growth factors and their binding proteins.	IGFBP3 IGFBP4	1.39e-05	8	25	2	10407151
Pubmed	Centaurin-alpha(1) associates with and is phosphorylated by isoforms of protein kinase C.	PRKCE PRKCI	1.39e-05	8	25	2	12893243
Pubmed	Gene expression of the insulin-like growth factor system during mouse kidney development.	IGFBP3 IGFBP4	1.78e-05	9	25	2	9324049
Pubmed	Regulation of HIV-1 gag protein subcellular targeting by protein kinase C.	PRKCE PRKCI	1.78e-05	9	25	2	7876252
Pubmed	Phosphorylation of HIV-1 gag proteins by protein kinase C.	PRKCE PRKCI	1.78e-05	9	25	2	8473314
Pubmed	mRNA expression patterns of the IGF system during mouse limb bud development, determined by whole mount in situ hybridization.	IGFBP3 IGFBP4	1.78e-05	9	25	2	9685224
Pubmed	Inhibition of protein kinase C by a synthetic peptide corresponding to cytoplasmic domain residues 828-848 of the human immunodeficiency virus type 1 envelope glycoprotein.	PRKCE PRKCI	1.78e-05	9	25	2	7850771
Pubmed	mRNA and protein localization of the IGF system during mouse embryonic development in areas with apoptosis.	IGFBP3 IGFBP4	1.78e-05	9	25	2	10502456
Pubmed	Expression of IGF ligand and receptor genes during preimplantation mammalian development.	IGFBP3 IGFBP4	1.78e-05	9	25	2	8398121
Pubmed	Human immunodeficiency virus-1 recombinant gp120 induces changes in protein kinase C isozymes--a preliminary report.	PRKCE PRKCI	1.78e-05	9	25	2	8206685
Pubmed	Effect of serine and tyrosine phosphorylation on retroviral proteinase substrates.	PRKCE PRKCI	2.22e-05	10	25	2	10491200
Pubmed	The phorbol ester TPA strongly inhibits HIV-1-induced syncytia formation but enhances virus production: possible involvement of protein kinase C pathway.	PRKCE PRKCI	2.22e-05	10	25	2	1970444
Pubmed	Inhibition of protein kinase C and anti-CD3-induced Ca2+ influx in Jurkat T cells by a synthetic peptide with sequence identity to HIV-1 gp41.	PRKCE PRKCI	2.22e-05	10	25	2	2139676
Pubmed	Human immunodeficiency virus induces phosphorylation of its cell surface receptor.	PRKCE PRKCI	2.22e-05	10	25	2	3259291
Pubmed	IL-16- and other CD4 ligand-induced migration is dependent upon protein kinase C.	PRKCE PRKCI	2.72e-05	11	25	2	8599832
Pubmed	Phosphorylation of tau is regulated by PKN.	PRKCE PRKCI	2.72e-05	11	25	2	11104762
Pubmed	In vitro phosphorylation of human immunodeficiency virus type 1 Tat protein by protein kinase C: evidence for the phosphorylation of amino acid residue serine-46.	PRKCE PRKCI	2.72e-05	11	25	2	8914829
Pubmed	Expression profile of protein kinase C isozymes in preimplantation mouse development.	PRKCE PRKCI	2.72e-05	11	25	2	16183862
Pubmed	Trans-activation of HIV-1 LTR-directed gene expression by tat requires protein kinase C.	PRKCE PRKCI	2.72e-05	11	25	2	2182321
Pubmed	IGFs increase enamel formation by inducing expression of enamel mineralizing specific genes.	IGFBP3 IGFBP4	2.72e-05	11	25	2	15721138
Pubmed	Specific isoforms of protein kinase C are essential for prevention of folate-resistant neural tube defects by inositol.	PRKCE PRKCI	2.72e-05	11	25	2	14613966
Pubmed	Cellular patterns of insulin-like growth factor system gene expression in murine chondrogenesis and osteogenesis.	IGFBP3 IGFBP4	2.72e-05	11	25	2	7750499
Pubmed	Involvement of protein kinase C in HIV-1 gp120-induced apoptosis in primary endothelium.	PRKCE PRKCI	3.26e-05	12	25	2	11141237
Pubmed	HIV-1 Tat protein induces interleukin-10 in human peripheral blood monocytes: involvement of protein kinase C-betaII and -delta.	PRKCE PRKCI	3.26e-05	12	25	2	11919157
Pubmed	HIV-1 Tat and AIDS-associated cancer: targeting the cellular anti-cancer barrier?	PRKCE PRKCI	3.26e-05	12	25	2	18577246
Pubmed	c-FLIPL regulates PKC via AP-2 to inhibit Bax-mediated apoptosis induced by HIV-1 gp120 in Jurkat cells.	PRKCE PRKCI	3.26e-05	12	25	2	19363595
Pubmed	HIV-1 reverse transcriptase is phosphorylated in vitro and in a cellular system.	PRKCE PRKCI	3.85e-05	13	25	2	10641798
Pubmed	EGF-stimulated signaling by means of PI3K, PLCgamma1, and PKC isozymes regulates branching morphogenesis of the fetal mouse submandibular gland.	PRKCE PRKCI	3.85e-05	13	25	2	12761849
Pubmed	Expression of insulin-like growth factor binding proteins during mouse cochlear development.	IGFBP3 IGFBP4	4.49e-05	14	25	2	23813480
Pubmed	HIV-1 envelope glycoproteins induce activation of activated protein-1 in CD4+ T cells.	PRKCE PRKCI	4.49e-05	14	25	2	7642615
Pubmed	Extracellular human immunodeficiency virus type 1 Tat protein is associated with an increase in both NF-kappa B binding and protein kinase C activity in primary human astrocytes.	PRKCE PRKCI	5.18e-05	15	25	2	8627654
Pubmed	HIV envelope gp120 activates human arterial smooth muscle cells.	PRKCE PRKCI	5.18e-05	15	25	2	11504923
Pubmed	A synthetic peptide with sequence identity to the transmembrane protein GP41 of HIV-1 inhibits distinct lymphocyte activation pathways dependent on protein kinase C and intracellular calcium influx.	PRKCE PRKCI	5.92e-05	16	25	2	1832084
Pubmed	[HIV-1 Tat protein induces IL-10 production by human monocytes: implications of the PKC and calcium pathway].	PRKCE PRKCI	5.92e-05	16	25	2	11833470
Pubmed	Proteolysis of fibrillin-2 microfibrils is essential for normal skeletal development.	FBN2 ADAMTS6	7.54e-05	18	25	2	35503090
Pubmed	Eighteen insulin-like growth factor pathway genes, circulating levels of IGF-I and its binding protein, and risk of prostate and breast cancer.	IGFBP3 IGFBP4	7.54e-05	18	25	2	20810604
Pubmed	Tat protein of human immunodeficiency virus type 1 induces interleukin-10 in human peripheral blood monocytes: implication of protein kinase C-dependent pathway.	PRKCE PRKCI	9.35e-05	20	25	2	11044099
Pubmed	Rapid cDNA sequencing (expressed sequence tags) from a directionally cloned human infant brain cDNA library.	ADAMTS6 RASGRP3	1.03e-04	21	25	2	8401585
Pubmed	Extracellular HIV-1 Tat protein induces a rapid and selective activation of protein kinase C (PKC)-alpha, and -epsilon and -zeta isoforms in PC12 cells.	PRKCE PRKCI	1.03e-04	21	25	2	9446795
Pubmed	The human immunodeficiency virus coat protein gp120 promotes forward trafficking and surface clustering of NMDA receptors in membrane microdomains.	PRKCE PRKCI	1.03e-04	21	25	2	22114277
Pubmed	Human immunodeficiency virus Tat protein induces interleukin 6 mRNA expression in human brain endothelial cells via protein kinase C- and cAMP-dependent protein kinase pathways.	PRKCE PRKCI	1.03e-04	21	25	2	9671211
Pubmed	HIV-1 Tat promotes monocyte chemoattractant protein-1 secretion followed by transmigration of monocytes.	PRKCE PRKCI	1.14e-04	22	25	2	11154208
Pubmed	The Nef protein of human immunodeficiency virus type 1 enhances serine phosphorylation of the viral matrix.	PRKCE PRKCI	1.14e-04	22	25	2	9151826
Pubmed	Release of calcium from inositol 1,4,5-trisphosphate receptor-regulated stores by HIV-1 Tat regulates TNF-alpha production in human macrophages.	PRKCE PRKCI	1.36e-04	24	25	2	10843712
Pubmed	Signalling crosstalk in FGF2-mediated protection of endothelial cells from HIV-gp120.	PRKCE PRKCI	1.47e-04	25	25	2	15689238
Pubmed	Identification of novel markers of mouse fetal ovary development.	RSPO1 EGFL6	1.60e-04	26	25	2	22844512
Pubmed	Involvement of Igf1r in Bronchiolar Epithelial Regeneration: Role during Repair Kinetics after Selective Club Cell Ablation.	IGFBP3 IGFBP4	1.60e-04	26	25	2	27861515
Pubmed	Mechanism of HIV-1-TAT induction of interleukin-1beta from human monocytes: Involvement of the phospholipase C/protein kinase C signaling cascade.	PRKCE PRKCI	1.72e-04	27	25	2	20336759
Pubmed	Role of phosphorylation in the nuclear biology of HIV-1.	PRKCE PRKCI	1.72e-04	27	25	2	21651489
Pubmed	Basement membrane assembly of the integrin α8β1 ligand nephronectin requires Fraser syndrome-associated proteins.	FREM1 EGFL6	1.99e-04	29	25	2	22613833
Pubmed	Layer V cortical neurons require microglial support for survival during postnatal development.	IGFBP3 IGFBP4	3.25e-04	37	25	2	23525041
Pubmed	The genetic program of hematopoietic stem cells.	SINHCAF CAPG	3.43e-04	38	25	2	10834841
Pubmed	Signaling pathways triggered by HIV-1 Tat in human monocytes to induce TNF-alpha.	PRKCE PRKCI	3.43e-04	38	25	2	12482669
Pubmed	Nell1-deficient mice have reduced expression of extracellular matrix proteins causing cranial and vertebral defects.	PRKCE PRKCI RSPO1	4.53e-04	210	25	3	16537572
Pubmed	The FOXG1/FOXO/SMAD network balances proliferation and differentiation of cortical progenitors and activates Kcnh3 expression in mature neurons.	IGFBP3 IGFBP4	4.61e-04	44	25	2	27224923
Pubmed	Targeted Disruption of Mouse Dip2B Leads to Abnormal Lung Development and Prenatal Lethality.	FBN2 IGFBP3	6.68e-04	53	25	2	33153107
Cytoband	7p22.1	RSPH10B2 RSPH10B	3.03e-04	47	25	2	7p22.1
Cytoband	Ensembl 112 genes in cytogenetic band chr7p22	RSPH10B2 RSPH10B	2.43e-03	134	25	2	chr7p22
GeneFamily	Insulin like growth factor binding proteins	IGFBP3 IGFBP4	9.62e-06	6	15	2	1065
GeneFamily	Ring finger proteins	TRIM34 RNF175	2.12e-02	275	15	2	58
Coexpression	HE_LIM_SUN_FETAL_LUNG_C0_ACTC_POS_SMC_CELL	PRKCE SINHCAF RNF175 FBN2 ADAMTS6 RSPO1	1.54e-05	589	25	6	M45662
Coexpression	RPS14_DN.V1_UP	FBN2 ADAMTS6 RASGRP3 CAPG	3.07e-05	191	25	4	M2816
Coexpression	NABA_ECM_GLYCOPROTEINS	FBN2 IGFBP3 IGFBP4 RSPO1	3.07e-05	191	25	4	MM17059
Coexpression	NABA_MATRISOME	FBN2 IGFBP3 IGFBP4 ADAMTS6 RSPO1 FREM1 EGFL6	3.19e-05	1008	25	7	MM17056
Coexpression	NABA_ECM_GLYCOPROTEINS	FBN2 IGFBP3 IGFBP4 RSPO1	3.39e-05	196	25	4	M3008
Coexpression	NABA_MATRISOME	FBN2 IGFBP3 IGFBP4 ADAMTS6 RSPO1 FREM1 EGFL6	3.57e-05	1026	25	7	M5889
Coexpression	HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION	FBN2 IGFBP3 IGFBP4 CAPG	3.67e-05	200	25	4	M5930
Coexpression	NABA_CORE_MATRISOME	FBN2 IGFBP3 IGFBP4 RSPO1	1.17e-04	270	25	4	MM17057
Coexpression	NABA_CORE_MATRISOME	FBN2 IGFBP3 IGFBP4 RSPO1	1.26e-04	275	25	4	M5884
Coexpression	HELLER_SILENCED_BY_METHYLATION_UP	CFP IGFBP3 IGFBP4 CAPG	1.41e-04	283	25	4	M8776
Coexpression	IIZUKA_LIVER_CANCER_PROGRESSION_L1_G1_UP	IGFBP3 IGFBP4	1.64e-04	20	25	2	M11507
Coexpression	WANG_NEOPLASTIC_TRANSFORMATION_BY_CCND1_MYC	IGFBP3 IGFBP4	1.99e-04	22	25	2	MM779
Coexpression	WANG_NEOPLASTIC_TRANSFORMATION_BY_CCND1_MYC	IGFBP3 IGFBP4	1.99e-04	22	25	2	M1867
Coexpression	INGRAM_SHH_TARGETS_UP	FBN2 IGFBP3 IGFBP4	2.26e-04	125	25	3	M1320
CoexpressionAtlas	B cells, B.FrE.FL, AA4.1+ IgM+ CD19+ CD43- CD24+, Fetal Liver, avg-3	PRKCE CFP ADAMTS6 RASGRP3 CAPG EGFL6	3.71e-06	372	25	6	GSM538204_500
CoexpressionAtlas	dev gonad_e12.5_F_VasAssocMesStromOvary_Sma_top-relative-expression-ranked_500	FBN2 IGFBP3 RSPO1 FREM1 EGFL6 ZSCAN18	4.52e-06	385	25	6	gudmap_dev gonad_e12.5_F_VasAssocMesStromOvary_Sma_500
CoexpressionAtlas	dev gonad_e11.5_F_GonadVasMes_Flk_top-relative-expression-ranked_1000	FBN2 IGFBP3 ADAMTS6 RSPO1 FREM1 EGFL6 ZSCAN18	3.55e-05	831	25	7	gudmap_dev gonad_e11.5_F_GonadVasMes_Flk_1000
CoexpressionAtlas	B cells, B1b.PC, IgD+ IgM+ CD19+ CD43+ CD5+ CD45R+, Peritoneal Cavity, avg-1	PRKCE CFP ADAMTS6 RASGRP3 CAPG	3.72e-05	332	25	5	GSM538230_500
CoexpressionAtlas	B cells, B1b.PC, IgD+ IgM+ CD19+ CD43+ CD5- CD45R+, Peritoneal Cavity, avg-2	PRKCE TRIM34 ADAMTS6 RASGRP3 CAPG	4.00e-05	337	25	5	GSM538228_500
CoexpressionAtlas	CD positive, CD19 Control, 19+ 4- 8-, Spleen, avg-6	PRKCE CFP ADAMTS6 RASGRP3 CAPG	4.11e-05	339	25	5	GSM403988_500
CoexpressionAtlas	kidney_adult_RenMedVasc_Tie2_k-means-cluster#2_top-relative-expression-ranked_500	TRIM34 IGFBP3 INPP5K RASGRP3	4.30e-05	169	25	4	gudmap_kidney_adult_RenMedVasc_Tie2_k2_500
CoexpressionAtlas	B cells, B.Fo.PC, IgD+ IgM+ CD19+ CD43- CD5- CD23+, Peritoneal Cavity, avg-3	PRKCE TRIM34 ADAMTS6 RASGRP3 CAPG	4.92e-05	352	25	5	GSM538198_500
CoexpressionAtlas	B cells, B.T3.Sp, IgD+ IgM+ CD45R+ CD24+ CD19+ AA4.1+ CD23+, Spleen, avg-3	PRKCE TRIM34 ADAMTS6 RASGRP3 CAPG	5.55e-05	361	25	5	GSM538219_500
CoexpressionAtlas	B cells, B.FrE.BM, CD19+ IgM+ AA4.1+ HSA+, Bone marrow, avg-3	PRKCE CFP RASGRP3 CAPG EGFL6	6.73e-05	376	25	5	GSM399438_500
CoexpressionAtlas	kidney_P4_CapMesRenVes_Crym_top-relative-expression-ranked_500	FBN2 RSPO1 MROH2A FREM1 EGFL6	8.80e-05	398	25	5	gudmap_kidney_P4_CapMesRenVes_Crym_500
CoexpressionAtlas	dev lower uro neuro_e15.5_PelvicGanglion_Sox10_k-means-cluster#4_top-relative-expression-ranked_1000	FBN2 ADAMTS6 FREM1 RASGRP3	2.30e-04	261	25	4	gudmap_dev lower uro neuro_e15.5_PelvicGanglion_Sox10_k4_1000
CoexpressionAtlas	dev gonad_e12.5_F_VasAssMesen_MafB_top-relative-expression-ranked_1000	FBN2 IGFBP4 RSPO1 FREM1 EGFL6 ZSCAN18	2.39e-04	783	25	6	gudmap_dev gonad_e12.5_F_VasAssMesen_MafB_1000
CoexpressionAtlas	dev gonad_e12.5_F_VasAssocMesStromOvary_Sma_top-relative-expression-ranked_1000	FBN2 IGFBP3 RSPO1 FREM1 EGFL6 ZSCAN18	2.63e-04	797	25	6	gudmap_dev gonad_e12.5_F_VasAssocMesStromOvary_Sma_1000
CoexpressionAtlas	kidney_adult_CortVasc_Tie2_k-means-cluster#2_top-relative-expression-ranked_200	TRIM34 IGFBP3	3.62e-04	24	25	2	gudmap_kidney_adult_CortVasc_Tie2_k2_200
CoexpressionAtlas	kidney_adult_CortVasc_Tie2_k-means-cluster#2_top-relative-expression-ranked_1000	TRIM34 IGFBP3 INPP5K RASGRP3	4.01e-04	302	25	4	gudmap_kidney_adult_CortVasc_Tie2_k2_1000
CoexpressionAtlas	dev lower uro neuro_e15.5_PelvicGanglion_Sox10_k-means-cluster#2_top-relative-expression-ranked_500	FBN2 FREM1 RASGRP3	4.36e-04	127	25	3	gudmap_dev lower uro neuro_e15.5_PelvicGanglion_Sox10_k2_500
CoexpressionAtlas	kidney_adult_RenMedVasc_Tie2_k-means-cluster#2_top-relative-expression-ranked_1000	TRIM34 IGFBP3 INPP5K RASGRP3	4.53e-04	312	25	4	gudmap_kidney_adult_RenMedVasc_Tie2_k2_1000
CoexpressionAtlas	B cells, B1a.PC, IgD+ IgM+ CD19+ CD43+ CD5+ CD45R+, Peritoneal Cavity, avg-3	PRKCE CFP ADAMTS6 CAPG	5.29e-04	325	25	4	GSM538222_500
CoexpressionAtlas	B cells, B.MZ.Sp, IgD+ IgM+ CD45R+ CD24+ CD19+ AA4.1- CD23- CD21.35+, Spleen, avg-1	PRKCE CFP RASGRP3 CAPG	5.35e-04	326	25	4	GSM538210_500
CoexpressionAtlas	dev gonad_e13.5_F_VascAssocMesenchStromOvary_MafB_top-relative-expression-ranked_200	FBN2 FREM1 EGFL6	5.45e-04	137	25	3	gudmap_dev gonad_e13.5_F_VascAssocMesenchStromOvary_MafB_200
CoexpressionAtlas	dev gonad_e13.5_F_VascAssocMesenchStromOvary_Sma_top-relative-expression-ranked_200	RSPO1 FREM1 EGFL6	6.17e-04	143	25	3	gudmap_dev gonad_e13.5_F_VascAssocMesenchStromOvary_Sma_200
CoexpressionAtlas	B cells, B.Fo.LN, CD19+ CD45R+ CD23+ CD21/35+, Lymph Node, avg-2	PRKCE TRIM34 RASGRP3 CAPG	6.19e-04	339	25	4	GSM777019_500
CoexpressionAtlas	B cells, B.MZ.Sp, IgD+ IgM+ CD45R+ CD24+ CD19+ AA4.1- CD23- CD21/35+, Spleen, avg-2	PRKCE CFP RASGRP3 CAPG	6.33e-04	341	25	4	GSM538211_500
CoexpressionAtlas	B cells, B.Fo.MLN, CD19+ CD45R+ CD23+ CD21/35+, Lymph Node, avg-3	PRKCE ADAMTS6 RASGRP3 CAPG	6.40e-04	342	25	4	GSM777021_500
CoexpressionAtlas	B cells, B.Fo.Sp, IgD+ IgM+ CD45R+ CD24+ CD19+ AA4.1- CD23+, Spleen, avg-3	PRKCE ADAMTS6 RASGRP3 CAPG	6.61e-04	345	25	4	GSM538201_500
CoexpressionAtlas	B cells, B1a.Sp, CD19+ CD45R+ IgM++ AA4.1- CD23- CD43+ CD5+, Spleen, avg-3	PRKCE CFP RASGRP3 CAPG	6.76e-04	347	25	4	GSM854229_500
CoexpressionAtlas	B cells, B.T2.Sp, IgD+ IgM+ CD45R+ CD24+ CD19+ AA4.1+ CD23+, Spleen, avg-3	PRKCE CFP RASGRP3 CAPG	6.83e-04	348	25	4	GSM538216_500
CoexpressionAtlas	dev gonad_e13.5_F_VascAssocMesenchStromOvary_MafB_k-means-cluster#1_top-relative-expression-ranked_200	FBN2 FREM1	6.87e-04	33	25	2	gudmap_dev gonad_e13.5_F_VascAssocMesenchStromOvary_MafB_k1_200
CoexpressionAtlas	placenta	FBN2 IGFBP3 ADAMTS6 EGFL6	6.91e-04	349	25	4	placenta
CoexpressionAtlas	B cells, B.T1.Sp, IgD+ IgM+ CD45R+ CD24+ CD19+ AA4.1+ CD23-, Spleen, avg-3	PRKCE CFP RASGRP3 CAPG	7.21e-04	353	25	4	GSM538213_500
CoexpressionAtlas	dev gonad_e13.5_F_VascAssocMesenchStromOvary_MafB_top-relative-expression-ranked_500	FBN2 RSPO1 FREM1 EGFL6	7.52e-04	357	25	4	gudmap_dev gonad_e13.5_F_VascAssocMesenchStromOvary_MafB_500
CoexpressionAtlas	dev gonad_e12.5_F_VasAssocMesStromOvary_Sma_top-relative-expression-ranked_200	RSPO1 FREM1 EGFL6	8.24e-04	158	25	3	gudmap_dev gonad_e12.5_F_VasAssocMesStromOvary_Sma_200
CoexpressionAtlas	B cells, B.FrF.BM, CD19+ IgM+ AA4.1- HSA+, Bone marrow, avg-3	PRKCE ADAMTS6 RASGRP3 CAPG	8.33e-04	367	25	4	GSM399440_500
CoexpressionAtlas	dev gonad_e13.5_F_VascAssocMesenchStromOvary_Sma_top-relative-expression-ranked_500	FBN2 RSPO1 FREM1 EGFL6	8.76e-04	372	25	4	gudmap_dev gonad_e13.5_F_VascAssocMesenchStromOvary_Sma_500
CoexpressionAtlas	kidney_adult_CortVasc_Tie2_top-relative-expression-ranked_200	TRIM34 IGFBP3 RASGRP3	8.86e-04	162	25	3	gudmap_kidney_adult_CortVasc_Tie2_200
CoexpressionAtlas	kidney_adult_CortVasc_Tie2_k-means-cluster#3_top-relative-expression-ranked_500	TRIM34 IGFBP3 RASGRP3	9.02e-04	163	25	3	gudmap_kidney_adult_CortVasc_Tie2_k3_500
CoexpressionAtlas	dev gonad_e13.5_F_VascAssocMesenchStromOvary_Sma_k-means-cluster#2_top-relative-expression-ranked_200	RSPO1 EGFL6	1.01e-03	40	25	2	gudmap_dev gonad_e13.5_F_VascAssocMesenchStromOvary_Sma_k2_200
CoexpressionAtlas	kidney_adult_GlomCapSys_Tie2_top-relative-expression-ranked_200	TRIM34 INPP5K RASGRP3	1.07e-03	173	25	3	gudmap_kidney_adult_GlomCapSys_Tie2_200
CoexpressionAtlas	kidney_P4_CapMesRenVes_Crym_top-relative-expression-ranked_200	FBN2 FREM1 EGFL6	1.11e-03	175	25	3	gudmap_kidney_P4_CapMesRenVes_Crym_200
CoexpressionAtlas	kidney_adult_RenMedVasc_Tie2_top-relative-expression-ranked_500	TRIM34 IGFBP3 INPP5K RASGRP3	1.34e-03	417	25	4	gudmap_kidney_adult_RenMedVasc_Tie2_500
CoexpressionAtlas	kidney_P4_CapMesRenVes_Crym_k-means-cluster#1_top-relative-expression-ranked_200	FBN2 FREM1	1.39e-03	47	25	2	gudmap_kidney_P4_CapMesRenVes_Crym_k1_200
ToppCell	droplet-Pancreas-PANCREAS-30m-Mesenchymal-pancreatic_stellate_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FBN2 IGFBP4 RSPO1 EGFL6	3.56e-06	189	25	4	1821ae4a6e37ee4c6308071883f3f447a7c53c53
ToppCell	Fibroblast-C\|World / shred on cell class and cell subclass (v4)	FBN2 IGFBP3 IGFBP4 RSPO1	3.56e-06	189	25	4	58e0400fbab5a0755504275aef5cf7986149abab
ToppCell	droplet-Pancreas-PANCREAS-30m-Mesenchymal-pancreatic_stellate_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FBN2 IGFBP4 RSPO1 EGFL6	3.56e-06	189	25	4	1e4d7e8dc98b3d70351e6a6c2aaf9ca01f141b8f
ToppCell	droplet-Pancreas-PANCREAS-30m-Mesenchymal\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FBN2 IGFBP4 RSPO1 EGFL6	3.56e-06	189	25	4	1dc415ed41815f4296dafd8cf7f3e014c44db1db
ToppCell	MatrixFB-Fibroblast-C\|MatrixFB / shred on cell class and cell subclass (v4)	FBN2 IGFBP3 IGFBP4 RSPO1	3.64e-06	190	25	4	d0106f7a21292f0b96ce4337ec3efbb1bd78dd0a
ToppCell	15-Trachea-Epithelial-Basal_cell\|Trachea / Age, Tissue, Lineage and Cell class	IGFBP3 IGFBP4 CAPG EGFL6	3.95e-06	194	25	4	67edcbb9ed1a01dd06b6f17621c54aa58df74c69
ToppCell	Brain_organoid-organoid_Kanton_Nature-Organoid-1M\|organoid_Kanton_Nature / Sample Type, Dataset, Time_group, and Cell type.	SINHCAF RNF175 FBN2 RSPO1	4.11e-06	196	25	4	1e9ccbd5be7839a74108f0cd07a6d2d736bc7f1b
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_ascending_limb_epithelial_cell-Ascending_Thin_Limb_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CFP FBN2 RSPH10B	5.17e-05	130	25	3	7d4319aae42acc914757796877b8f0d874acbec4
ToppCell	frontal_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Lmo1_Fam159b\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	FBN2 RSPO1 FREM1	7.61e-05	148	25	3	9205b26e0d042b342cc643cda0f4f3f8bb392d00
ToppCell	TCGA-Endometrium-Primary_Tumor-Endometrial_Adenocarcinoma-Serous_adenocarcinoma-5\|TCGA-Endometrium / Sample_Type by Project: Shred V9	PRKCI SINHCAF EGFL6	9.06e-05	157	25	3	59450e9f580555091b159fbbe0a0756e51bcd9ad
ToppCell	facs-Trachea-3m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell-smooth_muscle_cell_of_trachea_l1-41\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	FBN2 ADAMTS6 ZSCAN18	9.23e-05	158	25	3	6d2709b387945c015faa223c20d22b52a4082140
ToppCell	facs-Marrow-B-cells-24m-Lymphocytic-precursor_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FBN2 MROH2A FREM1	9.58e-05	160	25	3	c381ec6be8cf887861cc18f831a20db42f953fe1
ToppCell	facs-Marrow-B-cells-24m-Lymphocytic-pre_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FBN2 MROH2A FREM1	9.58e-05	160	25	3	25c8f3d2a6d14ff0ca0b965fce89d3ff22f40585
ToppCell	3'-GW_trimst-1-LargeIntestine-Mesenchymal-fibroblastic-Stromal_3_(KCNN3+)\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	AEBP2 FBN2 FREM1	1.03e-04	164	25	3	d167c7a987b9b35d1e7725c803df4f9cd5380e47
ToppCell	390C-Lymphocytic-NK_cells-NK_cell_B0\|NK_cells / Donor, Lineage, Cell class and subclass (all cells)	IGFBP3 ADAMTS6 RSPH10B	1.05e-04	165	25	3	ebd668e87e5961a124d1d6fc25d1f03e4af05cd4
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Myeloid-Monocytic-Non-classical_Monocyte\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	CFP RNF175 RSPH10B	1.13e-04	169	25	3	c3d410a5e98000ba872141b62e17ef4ed3d1a8eb
ToppCell	droplet-Kidney-nan-21m-Lymphocytic-CD45____B_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CFP RASGRP3 CAPG	1.13e-04	169	25	3	d44fc49056799dfc70a3c7d538c210d88ffded05
ToppCell	droplet-Kidney-nan-21m-Lymphocytic-B_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CFP RASGRP3 CAPG	1.15e-04	170	25	3	53fd50c9a27d47662fbcbd7e9e9837f72ac448c5
ToppCell	Mild-CD4+_T_Exhausted\|World / Disease group and Cell class	CFP TRIM34 IGFBP4	1.19e-04	172	25	3	efe68d9477aa873b1637ee689f298120303aa322
ToppCell	P03-Mesenchymal-developing_mesenchymal_cell-mesenchymal_immature_unknown_1\|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	IGFBP4 FREM1 RASGRP3	1.25e-04	175	25	3	282f09bbdfa70d93b3f66591dcfb84c5ee0268c7
ToppCell	E16.5-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	IGFBP3 IGFBP4 RASGRP3	1.27e-04	176	25	3	77516048aefbe1f48e825052756df0c310c1c486
ToppCell	droplet-Lung-1m-Hematologic-myeloid-classical_monocyte-classical_monocyte_l2\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CFP RSPO1 CAPG	1.27e-04	176	25	3	8f9d2a763b79cafe26dcbf3dba980d473a0b9873
ToppCell	droplet-Lung-1m-Hematologic-myeloid-classical_monocyte\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CFP RSPO1 CAPG	1.27e-04	176	25	3	3b5d12d5c22e32fbe80c3716ff14a7ae5769c165
ToppCell	E16.5-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC-AEC_mature\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	IGFBP3 IGFBP4 RASGRP3	1.27e-04	176	25	3	96779273b94345250cf53ba671203345b43d9e00
ToppCell	nucseq-Mesenchymal-Fibroblastic-Fibroblastic_1-Mesothelial\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	IGFBP3 IGFBP4 RSPO1	1.29e-04	177	25	3	0912a291cff32a4ff8a2d7680ed1a1cd867fb90f
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_PAX6-Inh_L1_PAX6_CA4\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	FBN2 IGFBP3 FREM1	1.31e-04	178	25	3	08b4a497aca0aeabf4f6a8a55c05b56417b69e78
ToppCell	5'-Airway_Nasal-Immune_Myeloid-Myeloid_monocytic-classical_monocyte-Classical_monocytes-Classical_monocytes_L.1.2.0.1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	AEBP2 CFP FBN2	1.34e-04	179	25	3	61dbfc1b9b0344c06a68142c181cd62993556a67
ToppCell	3'-GW_trimst-1.5-LargeIntestine-Endothelial-blood_vessel_EC-venous_capillary\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CFP IGFBP4 RASGRP3	1.36e-04	180	25	3	97e0dcb7cfbba60a782824c5e23995058609fcd4
ToppCell	droplet-Marrow-BM-1m-Myeloid-nan\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RSPO1 CAPG EGFL6	1.38e-04	181	25	3	89c551de26de047c316c91ac1d97bdf728a33d9e
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_PAX6\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	FBN2 IGFBP3 FREM1	1.38e-04	181	25	3	03a303cd2f366f09c18b118bbba6f5e3f95ad56c
ToppCell	3'-GW_trimst-2-SmallIntestine-Endothelial-blood_vessel_EC-Fetal_arterial_EC\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	IGFBP3 IGFBP4 RASGRP3	1.40e-04	182	25	3	0346f81bbb1f309f3e9d063b20547d548d09472c
ToppCell	facs-Heart-RA\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CFP IGFBP3 IGFBP4	1.40e-04	182	25	3	8292e8e8474c930ffb88cbab4f6ebdb6f58db645
ToppCell	facs-Thymus-Flowthrough-24m-Myeloid\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CFP RASGRP3 CAPG	1.43e-04	183	25	3	0513bb73552bfee609877d924fa97684200f595c
ToppCell	facs-Thymus-Flowthrough-24m-Myeloid-macrophage\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CFP RASGRP3 CAPG	1.43e-04	183	25	3	85b2335fa938a94e74251bd8d99de1bd21265ac9
ToppCell	facs-Thymus-Flowthrough-24m-Myeloid-macrophage\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CFP RASGRP3 CAPG	1.43e-04	183	25	3	6eeef55071ae25a61616df4fcfb2cea560aa7923
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FBN2 MROH2A FREM1	1.45e-04	184	25	3	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FBN2 MROH2A FREM1	1.45e-04	184	25	3	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FBN2 MROH2A FREM1	1.45e-04	184	25	3	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_PAX6\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	FBN2 IGFBP3 FREM1	1.47e-04	185	25	3	79cff4f3c6ae8e5ea60e8eae082b9275f2679ee9
ToppCell	P03-Mesenchymal-mesenchymal_fibroblast-mesenchymal_alveolar_niche_cell\|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	FBN2 IGFBP3 IGFBP4	1.50e-04	186	25	3	c0a036096c2cb23305605b8aaf18869d6e0fb512
ToppCell	droplet-Lung-LUNG-30m-Endothelial-endothelial_cell_of_lymphatic_vessel\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	IGFBP4 MROH2A RASGRP3	1.50e-04	186	25	3	f23f21781a758541f59c06efa7739d26a03fb478
ToppCell	droplet-Lung-LUNG-30m-Endothelial-Lymphatic_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	IGFBP4 MROH2A RASGRP3	1.50e-04	186	25	3	0de87109da9324c597fadf2eb782f0f158afe832
ToppCell	3'-GW_trimst-1.5-LargeIntestine-Endothelial-blood_vessel_EC\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	IGFBP3 IGFBP4 RASGRP3	1.52e-04	187	25	3	0ef82111b9049cc7ee78d64d240e1f10ab14d6b6
ToppCell	facs-Aorta-Heart-3m-Endothelial-nan\|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	IGFBP3 MROH2A RASGRP3	1.52e-04	187	25	3	df0279b7e94e26f5541b0e2a0ce56befa96ec8ca
ToppCell	droplet-Pancreas-Exocrine-18m-Mesenchymal-pancreatic_stellate_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FBN2 IGFBP4 RSPO1	1.52e-04	187	25	3	4e553721fa5598cb211f44e3226280b7e6885484
ToppCell	droplet-Pancreas-Exocrine-18m-Mesenchymal\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FBN2 IGFBP4 RSPO1	1.52e-04	187	25	3	d36e7fc6125e7a4310499365022d38f34b757a73
ToppCell	droplet-Pancreas-Exocrine-18m-Mesenchymal-pancreatic_stellate_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FBN2 IGFBP4 RSPO1	1.52e-04	187	25	3	827eae63fabf6892a82ce7779b5f395958d3d628
ToppCell	3'-GW_trimst-2-LargeIntestine-Endothelial-blood_vessel_EC-Fetal_arterial_EC\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	IGFBP3 IGFBP4 RASGRP3	1.52e-04	187	25	3	25efb82afe863a853ecdd781ad89026c993aaa67
ToppCell	3'-GW_trimst-1-SmallIntestine-Endothelial-blood_vessel_EC-arterial_capillary\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	IGFBP3 IGFBP4 RASGRP3	1.52e-04	187	25	3	50d5730e2cd4951d3ad0641fc81ae9f6ddabafe7
ToppCell	droplet-Marrow-nan-21m-Myeloid-macrophage\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RCC1L SINHCAF IGFBP4	1.54e-04	188	25	3	7c67330c36696a7772364af67c6df4e6406fa742
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-Adaptive_/_Maladaptive_/_Repairing_Fibroblast\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	IGFBP3 ADAMTS6 RSPO1	1.54e-04	188	25	3	ce85a56ac27a6432421dde93a1bafa8b943244b9
ToppCell	droplet-Marrow-nan-21m-Myeloid-Cd4_positive_Macrophages\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RCC1L SINHCAF IGFBP4	1.54e-04	188	25	3	f94dc08948a823f47882aa0714b9a60de4ff85d5
ToppCell	5'-GW_trimst-2-LargeIntestine-Endothelial-blood_vessel_EC-Fetal_arterial_EC\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	IGFBP3 IGFBP4 RASGRP3	1.57e-04	189	25	3	db09d591b885ce2bc9e353f08b6694e2192582e1
ToppCell	facs-Brain_Non-Myeloid-Striatum_-18m-Epithelial\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SINHCAF CAPG EGFL6	1.57e-04	189	25	3	6f0fc5271a7d3682f145e734abc3be6473dda2e2
ToppCell	Healthy-B_naive\|World / disease group, cell group and cell class	IGFBP4 ADAMTS6 RASGRP3	1.57e-04	189	25	3	1e533a43f739ff295740cf2b25479756dfb8e595
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-DC-cDC2-C\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	CFP TRIM34 CAPG	1.57e-04	189	25	3	cfa45fa6b13fcd3f54c29c823885f5b938812474
ToppCell	E16.5-Endothelial-Endothelial_blood-vessel-Macrovascular_EC\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	IGFBP3 IGFBP4 RASGRP3	1.57e-04	189	25	3	feedac2751ed770f80bc56fec31662b5b3826f58
ToppCell	facs-Brain_Non-Myeloid-Striatum_-18m-Epithelial-nan\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SINHCAF CAPG EGFL6	1.57e-04	189	25	3	3b9ce8964b16cb2200d30cbb0bfc711dcad2380e
ToppCell	ASK428-Epithelial-Transformed_epithelium\|ASK428 / Donor, Lineage and Cell class of Lung cells from Dropseq	IGFBP3 IGFBP4 EGFL6	1.57e-04	189	25	3	87189275234b5d59484c58acbb14a09903f2b578
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	IGFBP3 ADAMTS6 RSPO1	1.59e-04	190	25	3	efb757f11c2809e66ddb48a5c84f5433f111cb7c
ToppCell	Endothelial-A-Myositis-ILD_01\|World / lung cells shred on cell class, cell subclass, sample id	IGFBP3 IGFBP4 ADAMTS6	1.62e-04	191	25	3	f702dfe88a9b04091dae87df61b2b4f43525f86a
ToppCell	E18.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2-AF2_mature\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	FBN2 IGFBP3 IGFBP4	1.62e-04	191	25	3	75d2197076a9dfc868e8baf95bd4c5e44f438e3e
ToppCell	droplet-Heart-4Chambers-21m-Mesenchymal-fibroblast_of_cardiac_tissue\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	IGFBP3 IGFBP4 RSPO1	1.62e-04	191	25	3	f892f725a32e704cd18fec2f6d1db82993e7e79a
ToppCell	droplet-Pancreas-PANCREAS-30m-Endothelial-nan\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	IGFBP3 IGFBP4 RASGRP3	1.62e-04	191	25	3	471205494b91be69926dc8159376132bcea0d9b5
ToppCell	E18.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	FBN2 IGFBP3 IGFBP4	1.62e-04	191	25	3	4b50fdd310701251e64e16cd2d07ce03dbfd3e3e
ToppCell	droplet-Heart-4Chambers-21m-Mesenchymal-fibroblast\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	IGFBP3 IGFBP4 RSPO1	1.62e-04	191	25	3	44631226f59364098a7dd58058e6970a75441009
ToppCell	Healthy-B_naive\|Healthy / disease group, cell group and cell class	IGFBP4 ADAMTS6 RASGRP3	1.64e-04	192	25	3	5fddf679dcc9c0077d6bfe04c1e602863fb959eb
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-TAM-BDM-TAM-BDM_MHC-E\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	PRKCE CFP CAPG	1.64e-04	192	25	3	fcdb2e924800457d21e4aaeeedd81dbf80216eed
ToppCell	droplet-Pancreas-Exocrine-18m-Endothelial-nan\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	IGFBP3 IGFBP4 CAPG	1.64e-04	192	25	3	a42aed9e563f5f4af029b8804c104f11ad227a8f
ToppCell	PND03-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	FBN2 IGFBP3 IGFBP4	1.64e-04	192	25	3	ad48c941a3ddfd9a5146bafc2209da577bb50531
ToppCell	PND03-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2-AF2_mature\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	FBN2 IGFBP3 IGFBP4	1.64e-04	192	25	3	19b94f254d51b9bda3d9b7c6f85e27ecb58409c8
ToppCell	LPS-IL1RA+antiTNF-Endothelial-Endothelial-Gen_Cap\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PRKCE ADAMTS6 RASGRP3	1.67e-04	193	25	3	e09387af84d2a0a526e54d4793e6e06c6739db53
ToppCell	LPS-antiTNF-Endothelial-Endothelial-Gen_Cap\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PRKCE ADAMTS6 RASGRP3	1.67e-04	193	25	3	6e1982d089a9de628e6006d23ff78a223fbd9f47
ToppCell	LPS-IL1RA-Endothelial-Endothelial-Gen_Cap\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PRKCE ADAMTS6 RASGRP3	1.69e-04	194	25	3	0b9cd96fa0b616da7cc90e92ff71157e9bba518f
ToppCell	PCW_07-8.5-Endothelial-Endothelial_immature-endo_immature1_(0)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	CFP IGFBP4 RASGRP3	1.69e-04	194	25	3	2e3a64bda7c76fd0c99e93de0215f236e8045d83
ToppCell	PCW_10-12-Endothelial-Endothelial_mature-endo_venous_(13)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	CFP IGFBP4 RASGRP3	1.69e-04	194	25	3	efd5efed060edb7f24d59600981bb60ec28ac2ef
ToppCell	Fetal_29-31_weeks-Endothelial-endothelial_cell_of_vein\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	IGFBP4 ADAMTS6 RASGRP3	1.69e-04	194	25	3	fc2e0081005c0c496e41197a2d06e4a37708221f
ToppCell	droplet-Heart-nan-18m-Mesenchymal-fibroblast\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	IGFBP3 IGFBP4 RSPO1	1.72e-04	195	25	3	9ffabd831c2a0de3597f328e83db7ee259cb0ccc
ToppCell	mild_COVID-19_(asymptomatic)-B_naive\|World / disease group, cell group and cell class (v2)	IGFBP4 RASGRP3 ZSCAN18	1.72e-04	195	25	3	e763d9a431052c03cc6d514f2736506c6667e2be
ToppCell	droplet-Heart-nan-18m-Mesenchymal-fibroblast_of_cardiac_tissue\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	IGFBP3 IGFBP4 RSPO1	1.72e-04	195	25	3	613bea20c3d82c22a6af4c1a668af6fcf11fec0a
ToppCell	ASK428-Epithelial-Transformed_epithelium\|Epithelial / Donor, Lineage and Cell class of Lung cells from Dropseq	IGFBP3 IGFBP4 EGFL6	1.72e-04	195	25	3	c750602c765a51075ba6ede78e3ba80b62374481
ToppCell	E12.5-Mesenchymal-mesenchymal_fibroblast-mesenchymal_alveolar_niche_cell\|E12.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	IGFBP3 IGFBP4 EGFL6	1.72e-04	195	25	3	febe746099964b9ea9e75f2efc72c962c01f0421
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Endothelial\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	IGFBP4 ADAMTS6 RASGRP3	1.74e-04	196	25	3	48b4a9cea97a55190217deaf51bf867608c5a9a7
ToppCell	5'-GW_trimst-2-SmallIntestine-Endothelial-blood_vessel_EC-Fetal_arterial_EC\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	IGFBP3 IGFBP4 RASGRP3	1.74e-04	196	25	3	ae46d4b00be92e64e46252dcc156161b171eded4
ToppCell	3'-GW_trimst-1-LargeIntestine-Mesenchymal-immature_mesenchymal_cell-Mesoderm_1_(HAND1+)\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	IGFBP3 ADAMTS6 FREM1	1.74e-04	196	25	3	fd0a2b863dedaf08d18e7f67da18ac7e853991e4
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	IGFBP4 ADAMTS6 RASGRP3	1.74e-04	196	25	3	b8f89a50114932c08fc5daac4b549adfe9df8e66
ToppCell	5'-GW_trimst-1.5-SmallIntestine-Endothelial\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	IGFBP3 IGFBP4 RASGRP3	1.74e-04	196	25	3	ccf6881c09e570116cf1bcb71112765ea8c28418
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-Mono-Mono_hypoxia-C\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	CFP TRIM34 CAPG	1.74e-04	196	25	3	9ae9cf69079b8a786e775c3db5cd4c593513f698
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	IGFBP4 ADAMTS6 RASGRP3	1.74e-04	196	25	3	473980c827443464d08a0be28c53e3536369b12a
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Endothelial\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	IGFBP4 ADAMTS6 RASGRP3	1.74e-04	196	25	3	adee900dcd16dbaba15c58bdcace09ba20214950
ToppCell	wk_08-11-Mesenchymal-Fibroblast-Adventitial_fibro\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	FBN2 IGFBP4 EGFL6	1.74e-04	196	25	3	eed9fe83ffc1f79493b70778962a671dd9f481e0
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Endothelial-blood_vessel_endothelial_cell_of_kidney\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	IGFBP4 ADAMTS6 RASGRP3	1.74e-04	196	25	3	22767bcf0095d9eb0cbed7cdc74e4d32d9357e1b
ToppCell	3'-GW_trimst-1.5-LargeIntestine-Endothelial\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	IGFBP3 IGFBP4 RASGRP3	1.74e-04	196	25	3	629236f95c838a473b5964a49b7c1b7ad863ea12
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	IGFBP4 ADAMTS6 RASGRP3	1.74e-04	196	25	3	8f2031b1a9232c389517fbf3c29f47f9468b0077
ToppCell	PCW_05-06-Endothelial-Endothelial_immature-endo_immature_venous_(4)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	CFP IGFBP4 RASGRP3	1.74e-04	196	25	3	85b697db1c925eff8bbef9d74565c82be5a0ddcc
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Endothelial\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	IGFBP4 ADAMTS6 RASGRP3	1.74e-04	196	25	3	d0ff1082898d2db47c88d2678466514e9e9193d3
ToppCell	3'-GW_trimst-1-LargeIntestine-Mesenchymal-fibroblastic\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	IGFBP3 IGFBP4 EGFL6	1.77e-04	197	25	3	6668f0da54f3bf96769275e668cd57e00b8a5ef9
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Endothelial-Endothelial_mature-Endo_capilar\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	IGFBP3 IGFBP4 RASGRP3	1.77e-04	197	25	3	e567f91fa398fd306d025dcfe89bd50a60216537
ToppCell	PCW_13-14-Endothelial-Endothelial_immature-endo_immature3_(11)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	CFP IGFBP4 RASGRP3	1.77e-04	197	25	3	21a1080e1db3a64f3eccc7aed2b3189332d31038
ToppCell	5'-GW_trimst-1.5-LargeIntestine-Mesenchymal-immature_mesenchymal_cell-Mesoderm_1_(HAND1+)\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	RNF175 IGFBP4 ADAMTS6	1.77e-04	197	25	3	2a90422ba400b951517603a916f34221056d0f3d
Drug	digoxigenine	PRKCE CFP PRKCI	1.12e-05	40	25	3	CID000015478
Drug	tubulin polymerization inhibitor	PRKCE PRKCI SINHCAF CAPG	1.66e-05	142	25	4	CID010125800
Drug	CAS 68-19-9	PRKCE PRKCI IGFBP3 IGFBP4	1.80e-05	145	25	4	CID000002891
Drug	lead compounds	PRKCE CFP PRKCI FBN2	2.06e-05	150	25	4	CID000073212
Drug	HMBA	PRKCE PRKCI SINHCAF CAPG	2.46e-05	157	25	4	CID000003616
Drug	AC1L1ERT	PRKCE PRKCI CAPG	5.84e-05	69	25	3	CID000002920
Drug	C-1b	PRKCE PRKCI RASGRP3	6.63e-05	72	25	3	CID006102740
Drug	AC1MQFW8	PRKCE INPP5K	7.59e-05	12	25	2	CID003451126
Drug	D-myo-inositol 1,4-bisphosphate	PRKCE PRKCI INPP5K	1.13e-04	86	25	3	CID000000805
Drug	RK-1409B	PRKCE PRKCI	1.20e-04	15	25	2	CID003036125
Drug	dansyl-DAG	PRKCE PRKCI	1.20e-04	15	25	2	CID000129493
Drug	1-stearoyl-2-arachidonylglycerol	PRKCE PRKCI	1.20e-04	15	25	2	CID006443869
Drug	Rgd Peptide	FBN2 IGFBP4 RSPO1 EGFL6	1.26e-04	239	25	4	CID000104802
Drug	daphnoretin	PRKCE PRKCI	1.56e-04	17	25	2	CID005281406
Drug	AC1L1JQC	PRKCE PRKCI	1.56e-04	17	25	2	CID000005157
Drug	lead chromate	PRKCE PRKCI FBN2	1.66e-04	98	25	3	CID000024460
Drug	dipalmitin	PRKCE PRKCI	1.75e-04	18	25	2	CID000068149
Drug	Cgp-42700	PRKCE PRKCI	1.75e-04	18	25	2	CID000188390
Drug	dihydrosterculic acid	PRKCE PRKCI	1.75e-04	18	25	2	CID000160788
Drug	TAPP-Br	PRKCE PRKCI	1.96e-04	19	25	2	CID000160326
Drug	sapintoxin A	PRKCE PRKCI	1.96e-04	19	25	2	CID000108085
Drug	H-8105	PRKCE CFP PRKCI INPP5K	2.37e-04	282	25	4	CID000164531
Drug	1-aminocyclopentane-1,3-dicarboxylate	PRKCE CFP PRKCI	2.40e-04	111	25	3	CID000001310
Drug	KS-619-1	PRKCE PRKCI	2.40e-04	21	25	2	CID000128369
Drug	K-259-2	PRKCE PRKCI	2.40e-04	21	25	2	CID006438946
Drug	debromoaplysiatoxin	PRKCE PRKCI	2.40e-04	21	25	2	CID000002967
Drug	broussochalcone A	PRKCE PRKCI	2.40e-04	21	25	2	CID006438825
Drug	MDL 27,032	PRKCE PRKCI	2.40e-04	21	25	2	CID000163812
Drug	daunorubicin semiquinone	PRKCE PRKCI IGFBP3 IGFBP4	2.47e-04	285	25	4	CID000002958
Drug	cholesterol sulfate	PRKCE CFP PRKCI	2.53e-04	113	25	3	CID000065076
Drug	tyrphostin 23	PRKCE PRKCI IGFBP4	2.73e-04	116	25	3	CID000002052
Drug	tautomycin	PRKCE PRKCI INPP5K	2.87e-04	118	25	3	CID000440646
Drug	AC1L4NFY	PRKCE PRKCI	2.89e-04	23	25	2	CID000160335
Drug	Bb 2116	IGFBP3 IGFBP4	3.42e-04	25	25	2	CID005479989
Drug	1-alpha-25-dihydroxycholecalciferol	PRKCE PRKCI TRIM34 IGFBP3 IGFBP4 SBNO1	3.67e-04	909	25	6	CID000002524
Drug	beta-tocopherol	PRKCE PRKCI	4.00e-04	27	25	2	CID000008989
Drug	ilmofosine	PRKCE PRKCI	4.00e-04	27	25	2	CID000055008
Drug	pseudohypericin	PRKCE PRKCI	4.00e-04	27	25	2	CID005281751
Drug	C15720	PRKCE PRKCI	4.00e-04	27	25	2	CID000003979
Drug	bisindolylmaleimide II	PRKCE PRKCI	4.30e-04	28	25	2	CID000002397
Drug	bisindolylmaleimide V	PRKCE PRKCI	4.30e-04	28	25	2	CID000002400
Drug	aplysiatoxin	PRKCE PRKCI	4.30e-04	28	25	2	CID000040465
Drug	HBDDE	PRKCE PRKCI	4.30e-04	28	25	2	CID000003568
Drug	SC-10	PRKCE PRKCI	4.30e-04	28	25	2	CID000005175
Drug	NCDC	PRKCE PRKCI	4.30e-04	28	25	2	CID000001583
Drug	AC1Q6DXY	PRKCE PRKCI	4.61e-04	29	25	2	CID000003719
Drug	Polychlorinated biphenyls	PRKCE PRKCI	4.61e-04	29	25	2	CID000006636
Drug	AC1L1B58	PRKCE PRKCI	4.61e-04	29	25	2	CID000001288
Drug	AC1L1O6Q	PRKCE PRKCI IGFBP4	4.84e-04	141	25	3	CID000058035
Drug	aluminum sulfate	IGFBP3 IGFBP4	4.94e-04	30	25	2	ctd:C041524
Drug	Gf 109	PRKCE PRKCI	4.94e-04	30	25	2	CID000196144
Drug	AC1L3G0K	PRKCE PRKCI	4.94e-04	30	25	2	CID000114822
Drug	12-deoxyphorbol 13-phenylacetate	PRKCE PRKCI	4.94e-04	30	25	2	CID000105100
Drug	muscarine	PRKCE PRKCI INPP5K	5.15e-04	144	25	3	CID000009308
Drug	N,n,n-tms	PRKCE PRKCI	5.28e-04	31	25	2	CID006439410
Drug	DiC8	PRKCE PRKCI RASGRP3	5.36e-04	146	25	3	CID000001323
Drug	AC1L1K7T	PRKCE CFP PRKCI IGFBP3 IGFBP4	5.43e-04	632	25	5	CID000005376
Drug	25(OH) vitamin D3	PRKCE PRKCI IGFBP3	5.80e-04	150	25	3	CID000001593
Drug	CGS 9343B	PRKCE PRKCI	5.99e-04	33	25	2	CID000065909
Drug	naphthalenesulfonamide	PRKCE PRKCI	5.99e-04	33	25	2	CID000163571
Drug	AC1L1FGW	PRKCE PRKCI	5.99e-04	33	25	2	CID000003231
Drug	4-O-methyl-TPA	PRKCE PRKCI	6.36e-04	34	25	2	CID000072292
Drug	AC1NSKHR	PRKCE PRKCI	6.36e-04	34	25	2	CID005311362
Drug	AC1N8GZI	PRKCE CFP	6.36e-04	34	25	2	CID004343649
Drug	h x mg	PRKCE PRKCI	6.36e-04	34	25	2	CID000001380
Drug	Iamin	IGFBP3 IGFBP4	6.74e-04	35	25	2	CID000073587
Drug	paracrystals	PRKCE PRKCI FBN2	7.12e-04	161	25	3	CID000004685
Drug	losartan	PRKCE PRKCI FBN2 IGFBP3	7.18e-04	378	25	4	CID000003961
Drug	AC1NRBPT	PRKCE IGFBP3 IGFBP4	7.25e-04	162	25	3	CID005288571
Drug	norathyriol	PRKCE PRKCI	7.53e-04	37	25	2	CID005281656
Drug	Fim 1	PRKCE PRKCI	7.53e-04	37	25	2	CID000132906
Drug	HOE 694	PRKCE PRKCI	7.53e-04	37	25	2	CID000123840
Drug	cerium dimer	CFP CAPG	7.53e-04	37	25	2	CID000139339
Drug	iso-H7	PRKCE PRKCI	7.53e-04	37	25	2	CID000001352
Drug	Jmv 180	PRKCE PRKCI	7.94e-04	38	25	2	CID003035023
Drug	DB04780	PRKCE CFP PRKCI	8.34e-04	170	25	3	CID005459389
Drug	Ro 31-7549	PRKCE PRKCI	8.37e-04	39	25	2	CID000002403
Drug	12-deoxyphorbol 13-isobutyrate	PRKCE PRKCI	8.37e-04	39	25	2	CID000107855
Drug	AC1L1KEH	PRKCE PRKCI	8.80e-04	40	25	2	CID000005462
Drug	Go6983	PRKCE PRKCI	8.80e-04	40	25	2	CID000003499
Drug	1-stearoyl-2-arachidonoyl-sn-glycerol	PRKCE PRKCI	8.80e-04	40	25	2	CID000001398
Drug	12-deoxyphorbol 13-acetate	PRKCE PRKCI	9.25e-04	41	25	2	CID000004962
Drug	Eli	IGFBP3 IGFBP4	9.25e-04	41	25	2	CID009549220
Drug	D-triiodothyronine	PRKCE PRKCI IGFBP3 IGFBP4	9.63e-04	409	25	4	CID000000861
Drug	PEP005	PRKCE PRKCI	9.70e-04	42	25	2	CID006918670
Drug	antibiotic from Streptomyces	PRKCE PRKCI	9.70e-04	42	25	2	CID000005153
Drug	benzenesulfonate	PRKCE PRKCI	9.70e-04	42	25	2	CID000007371
Drug	benzoyl	PRKCE PRKCI	1.02e-03	43	25	2	CID000007187
Drug	AC1LDMDX	PRKCE PRKCI	1.02e-03	43	25	2	CID000621355
Drug	SC-9	PRKCE PRKCI	1.02e-03	43	25	2	CID000124172
Drug	retinoic acid; Up 200; 1uM; HL60; HG-U133A	PRKCE CFP INPP5K	1.05e-03	184	25	3	390_UP
Drug	AC1L1D09	CFP INPP5K	1.06e-03	44	25	2	CID000002139
Drug	rhodamine 6G	PRKCE PRKCI	1.06e-03	44	25	2	CID000013806
Drug	Salbutamol [18559-94-9]; Up 200; 16.8uM; HL60; HT_HG-U133A	CFP IGFBP4 INPP5K	1.10e-03	187	25	3	2344_UP
Disease	congenital diaphragmatic hernia (biomarker_via_orthology)	IGFBP3 FREM1	1.73e-04	24	24	2	DOID:3827 (biomarker_via_orthology)
Disease	multiple system atrophy	FBN2 RASGRP3	4.85e-04	40	24	2	EFO_1001050
Disease	Colorectal Neoplasms	PRKCE FBN2 IGFBP3	1.43e-03	277	24	3	C0009404
Disease	Agents acting on the renin-angiotensin system use measurement	PRKCE FBN2 IGFBP3	2.46e-03	335	24	3	EFO_0009931
Disease	corneal topography	ADAMTS6 RSPO1	3.54e-03	109	24	2	EFO_0004345
Disease	cardiovascular disease	PRKCE FBN2 FREM1	5.87e-03	457	24	3	EFO_0000319
Disease	venous thromboembolism	PRKCE IGFBP3 SBNO1	5.97e-03	460	24	3	EFO_0004286
Disease	intraocular pressure measurement	FBN2 ADAMTS6 RSPO1	7.89e-03	509	24	3	EFO_0004695

Protein segments in the cluster

Peptide	Gene	Start	Entry
RGGVFVCLWKGCKVY	AEBP2	291	Q6ZN18
KLACCYGWRRNSKGV	EGFL6	46	Q8IUX8
LCQTGNIEKGWCYQG	ADAMTS6	531	Q9UKP5
NKGELFVWGKNIRGC	RCC1L	411	Q96I51
NIKKGWGIRCYKSGN	RSPH10B	211	P0C881
NIKKGWGIRCYKSGN	RSPH10B2	211	B2RC85
IIKKSGNNRCWRGCG	nan	1121	O00370
IWGLGRQGYKCINCK	PRKCI	161	P41743
WGVIGKQGYQCQVCT	PRKCE	191	Q02156
GIQKLYQCNGIAWKA	FREM1	2026	Q5H8C1
YRRCVGWNGQCSGKV	CFP	101	P27918
WGNKGGVNICLKLYG	INPP5K	126	Q9BT40
DNGLCGKIYIWKGRK	CAPG	286	P40121
LYWDVAGGCKQLKNR	EML3	751	Q32P44
FKCSCREGWIGNGIK	FBN2	1391	P35556
YWRGNCKKASLGLVC	SBNO1	1281	A3KN83
GRKRGFCWCVDKYGQ	IGFBP3	256	P17936
ALCGYQERIKGWGLK	MROH2A	456	A6NES4
GYWVIGLQNKCKYGV	TRIM34	396	Q9BYJ4
NKQRCARLWKIAYGG	TEDDM1	16	Q5T9Z0
CAGFLWGIIKQGYKC	RASGRP3	511	Q8IV61
WGIIKQGYKCKDCGA	RASGRP3	516	Q8IV61
WGPCSKKQQLCGFRR	RSPO1	156	Q2MKA7
GQRGKCWCVDRKTGV	IGFBP4	221	P22692
YWKRQKICCGIIYKG	SINHCAF	166	Q9NP50
IRGWCIVGKKQTCPY	RNF175	261	Q8N4F7
GGRKRYACQGCWKTF	ZSCAN18	436	Q8TBC5