Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	enzyme regulator activity	BMP2K MYCBP2 SLC38A9 DBF4B ATG13 LMTK2 ARHGAP39 CCNH ARHGAP5 ARHGEF33 CCNYL1 WDR6 EIF5 KNDC1 GNAS AGAP7P AGAP4 AGAP6 CCNYL2 PLCE1	1.43e-04	1418	114	20	GO:0030234
GeneOntologyMolecularFunction	nucleoside-triphosphatase regulator activity	MYCBP2 SLC38A9 ARHGAP39 ARHGAP5 ARHGEF33 EIF5 KNDC1 AGAP7P AGAP4 AGAP6 PLCE1	1.55e-04	507	114	11	GO:0060589
GeneOntologyMolecularFunction	GTPase regulator activity	MYCBP2 SLC38A9 ARHGAP39 ARHGAP5 ARHGEF33 EIF5 KNDC1 AGAP7P AGAP4 AGAP6 PLCE1	1.55e-04	507	114	11	GO:0030695
GeneOntologyMolecularFunction	linoleic acid epoxygenase activity	CYP2C19 CYP2C18	1.92e-04	4	114	2	GO:0071614
GeneOntologyCellularComponent	NF-kappaB p50/p65 complex	RELA NFKB1	3.05e-05	2	116	2	GO:0035525
GeneOntologyCellularComponent	histone acetyltransferase complex	KANSL1L ING5 ING4 KAT6B KAT14	1.79e-04	94	116	5	GO:0000123
GeneOntologyCellularComponent	protein acetyltransferase complex	KANSL1L ING5 ING4 KAT6B KAT14	2.87e-04	104	116	5	GO:0031248
GeneOntologyCellularComponent	NF-kappaB complex	RELA NFKB1	3.02e-04	5	116	2	GO:0071159
GeneOntologyCellularComponent	acetyltransferase complex	KANSL1L ING5 ING4 KAT6B KAT14	3.56e-04	109	116	5	GO:1902493
GeneOntologyCellularComponent	glutamatergic synapse	SEMA4F TSPOAP1 KCNAB2 NTNG1 RELA SRCIN1 ARHGAP39 SHANK3 PTPRZ1 KCNN2 RNF216 MAPK3 HTT	6.08e-04	817	116	13	GO:0098978
GeneOntologyCellularComponent	MOZ/MORF histone acetyltransferase complex	ING5 KAT6B	6.30e-04	7	116	2	GO:0070776
GeneOntologyCellularComponent	H3 histone acetyltransferase complex	ING5 KAT6B	8.36e-04	8	116	2	GO:0070775
Domain	LRRC37AB_C	LRRC37A3 LRRC37A2 LRRC37A	9.06e-07	4	115	3	IPR029423
Domain	LRRC37AB_C	LRRC37A3 LRRC37A2 LRRC37A	9.06e-07	4	115	3	PF14914
Domain	LRRC37_N	LRRC37A3 LRRC37A2 LRRC37A	9.06e-07	4	115	3	IPR032754
Domain	LRRC37	LRRC37A3 LRRC37A2 LRRC37A	9.06e-07	4	115	3	PF15779
Domain	LRRC37A/B-like	LRRC37A3 LRRC37A2 LRRC37A	9.06e-07	4	115	3	IPR015753
Domain	-	DBF4B MDC1 CTDP1	3.68e-04	23	115	3	3.40.50.10190
Domain	ING	ING5 ING4	3.71e-04	5	115	2	SM01408
Domain	IPT_NFkappaB	RELA NFKB1	3.71e-04	5	115	2	IPR033926
Domain	ING_N_histone_binding	ING5 ING4	3.71e-04	5	115	2	IPR024610
Domain	RHD_CS	RELA NFKB1	3.71e-04	5	115	2	IPR030492
Domain	ING	ING5 ING4	3.71e-04	5	115	2	PF12998
Domain	ING_fam	ING5 ING4	3.71e-04	5	115	2	IPR028651
Domain	BRCT	DBF4B MDC1 CTDP1	5.33e-04	26	115	3	PS50172
Domain	BRCT_dom	DBF4B MDC1 CTDP1	6.66e-04	28	115	3	IPR001357
Domain	ArfGap	AGAP7P AGAP4 AGAP6	7.39e-04	29	115	3	SM00105
Domain	ARFGAP	AGAP7P AGAP4 AGAP6	7.39e-04	29	115	3	PS50115
Domain	ArfGap	AGAP7P AGAP4 AGAP6	7.39e-04	29	115	3	PF01412
Domain	ArfGAP	AGAP7P AGAP4 AGAP6	7.39e-04	29	115	3	IPR001164
Domain	PHD	ING5 KMT2E ING4 KAT6B	1.18e-03	75	115	4	PF00628
Domain	Znf_PHD-finger	ING5 KMT2E ING4 KAT6B	1.44e-03	79	115	4	IPR019787
Domain	RHD_dimer	RELA NFKB1	1.64e-03	10	115	2	IPR032397
Domain	RHD_dimer	RELA NFKB1	1.64e-03	10	115	2	PF16179
Domain	REL_1	RELA NFKB1	1.64e-03	10	115	2	PS01204
Domain	-	RELA NFKB1	1.64e-03	10	115	2	2.60.40.340
Domain	NFkB/Dor	RELA NFKB1	1.64e-03	10	115	2	IPR000451
Domain	RHD_DNA_bind_dom	RELA NFKB1	1.64e-03	10	115	2	IPR011539
Domain	RHD_DNA_bind	RELA NFKB1	1.64e-03	10	115	2	PF00554
Domain	REL_2	RELA NFKB1	1.64e-03	10	115	2	PS50254
Domain	PH	PLEKHA6 SPTBN5 OSBPL7 AGAP7P AGAP4 AGAP6 GAB1	1.68e-03	278	115	7	SM00233
Domain	PH_DOMAIN	PLEKHA6 SPTBN5 OSBPL7 AGAP7P AGAP4 AGAP6 GAB1	1.71e-03	279	115	7	PS50003
Domain	PH_domain	PLEKHA6 SPTBN5 OSBPL7 AGAP7P AGAP4 AGAP6 GAB1	1.75e-03	280	115	7	IPR001849
Pathway	WP_RESISTIN_AS_A_REGULATOR_OF_INFLAMMATION	RELA NFKB1 MAPK3 PLCE1	4.41e-05	33	85	4	M39745
Pathway	WP_OSTEOPONTIN_SIGNALING	RELA NFKB1 MAPK3	5.79e-05	13	85	3	M39603
Pathway	BIOCARTA_CDMAC_PATHWAY	RELA NFKB1 MAPK3	9.14e-05	15	85	3	MM1358
Pathway	KEGG_MEDICUS_REFERENCE_AGE_RAGE_SIGNALING_PATHWAY	RELA NFKB1 MAPK3	1.12e-04	16	85	3	M47682
Pathway	BIOCARTA_CDMAC_PATHWAY	RELA NFKB1 MAPK3	1.12e-04	16	85	3	M4388
Pathway	BIOCARTA_GCR_PATHWAY	RELA NFKB1 GNAS	1.35e-04	17	85	3	M10066
Pathway	BIOCARTA_GCR_PATHWAY	RELA NFKB1 GNAS	1.35e-04	17	85	3	MM1372
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_ABETA_TO_AGE_RAGE_SIGNALING_PATHWAY	RELA NFKB1 MAPK3	1.35e-04	17	85	3	M47684
Pathway	BIOCARTA_HCMV_PATHWAY	RELA NFKB1 MAPK3	1.35e-04	17	85	3	M8353
Pathway	BIOCARTA_HCMV_PATHWAY	RELA NFKB1 MAPK3	1.35e-04	17	85	3	MM1408
Pathway	WP_THYMIC_STROMAL_LYMPHOPOIETIN_TSLP_SIGNALING	RELA NFKB1 MAPK3 IL2RA	1.80e-04	47	85	4	M39380
Pathway	BIOCARTA_CXCR4_PATHWAY	RELA NFKB1 MAPK3	1.91e-04	19	85	3	MM1375
Pathway	BIOCARTA_CXCR4_PATHWAY	RELA NFKB1 MAPK3	1.91e-04	19	85	3	M882
Pathway	BIOCARTA_CERAMIDE_PATHWAY	RELA NFKB1 MAPK3	2.60e-04	21	85	3	M19943
Pathway	BIOCARTA_RAS_PATHWAY	RELA NFKB1 MAPK3	2.60e-04	21	85	3	MM1464
Pathway	BIOCARTA_RAS_PATHWAY	RELA NFKB1 MAPK3	3.00e-04	22	85	3	M17294
Pathway	BIOCARTA_CERAMIDE_PATHWAY	RELA NFKB1 MAPK3	3.43e-04	23	85	3	MM1367
Pathway	KEGG_MEDICUS_VARIANT_FUS_DDIT3_FUSION_TO_NFKB_MEDIATED_TRANSCRIPTION	RELA NFKB1	3.55e-04	5	85	2	M48981
Pathway	KEGG_MEDICUS_PATHOGEN_SALMONELLA_SPVD_TO_TNF_NFKB_SIGNALING_PATHWAY	RELA NFKB1	3.55e-04	5	85	2	M48980
Pathway	BIOCARTA_RACCYCD_PATHWAY	RELA NFKB1 MAPK3	4.98e-04	26	85	3	M14512
Pathway	BIOCARTA_RACCYCD_PATHWAY	RELA NFKB1 MAPK3	4.98e-04	26	85	3	MM1423
Pathway	REACTOME_CLEC7A_INFLAMMASOME_PATHWAY	RELA NFKB1	5.31e-04	6	85	2	M27542
Pathway	KEGG_MEDICUS_PATHOGEN_KSHV_VFLIP_TO_NFKB_SIGNALING_PATHWAY	RELA NFKB1	5.31e-04	6	85	2	M47462
Pathway	REACTOME_NCAM_SIGNALING_FOR_NEURITE_OUT_GROWTH	COL5A2 SPTBN5 CACNA1I MAPK3	5.59e-04	63	85	4	M11187
Pathway	PID_HDAC_CLASSI_PATHWAY	GATA2 RELA SIRT1 NFKB1	6.68e-04	66	85	4	M101
Pathway	BIOCARTA_PKC_PATHWAY	RELA NFKB1	7.40e-04	7	85	2	M22057
Pathway	REACTOME_IKBA_VARIANT_LEADS_TO_EDA_ID	RELA NFKB1	7.40e-04	7	85	2	M27463
Pathway	BIOCARTA_PKC_PATHWAY	RELA NFKB1	7.40e-04	7	85	2	MM1572
Pathway	REACTOME_DEX_H_BOX_HELICASES_ACTIVATE_TYPE_I_IFN_AND_INFLAMMATORY_CYTOKINES_PRODUCTION	RELA NFKB1	7.40e-04	7	85	2	MM14930
Pathway	WP_ACTIVATION_OF_NLRP3_INFLAMMASOME_BY_SARSCOV2	RELA NFKB1	7.40e-04	7	85	2	M39874
Pathway	REACTOME_DEX_H_BOX_HELICASES_ACTIVATE_TYPE_I_IFN_AND_INFLAMMATORY_CYTOKINES_PRODUCTION	RELA NFKB1	7.40e-04	7	85	2	M27227
Pathway	KEGG_MEDICUS_PATHOGEN_KSHV_VFLIP_TO_TNF_NFKB_SIGNALING_PATHWAY	RELA NFKB1	7.40e-04	7	85	2	M47464
Pathway	PID_AVB3_OPN_PATHWAY	RELA NFKB1 MAPK3	8.42e-04	31	85	3	M63
Pathway	WP_PRION_DISEASE_PATHWAY	BCL11A NFKB1 MAPK3	9.25e-04	32	85	3	M39636
Pathway	WP_IL17_SIGNALING	RELA NFKB1 MAPK3	9.25e-04	32	85	3	M39560
Pathway	WP_CANONICAL_NFKB_PATHWAY	RELA NFKB1	9.83e-04	8	85	2	M39783
Pathway	REACTOME_REGULATION_OF_NFE2L2_GENE_EXPRESSION	RELA NFKB1	9.83e-04	8	85	2	M48024
Pathway	KEGG_MEDICUS_REFERENCE_ANGII_AT1R_NOX2_SIGNALING_PATHWAY	RELA NFKB1	9.83e-04	8	85	2	M47780
Pathway	BIOCARTA_FREE_PATHWAY	RELA NFKB1	9.83e-04	8	85	2	MM1400
Pathway	KEGG_MEDICUS_PATHOGEN_KSHV_K15_TO_TNF_NFKB_SIGNALING_PATHWAY	RELA NFKB1	9.83e-04	8	85	2	M47463
Pathway	WP_CAMKK2_PATHWAY	RELA SIRT1 MAPK3	1.01e-03	33	85	3	M40047
Pathway	BIOCARTA_FMLP_PATHWAY	RELA NFKB1 MAPK3	1.11e-03	34	85	3	MM1399
Pathway	BIOCARTA_FMLP_PATHWAY	RELA NFKB1 MAPK3	1.11e-03	34	85	3	M10287
Pathway	PID_IL2_PI3K_PATHWAY	RELA NFKB1 IL2RA	1.11e-03	34	85	3	M143
Pathway	WP_ALTERED_GLYCOSYLATION_OF_MUC1_IN_TUMOR_MICROENVIRONMENT	RELA NFKB1	1.26e-03	9	85	2	M39757
Pathway	BIOCARTA_RNA_PATHWAY	RELA NFKB1	1.26e-03	9	85	2	MM1382
Pathway	KEGG_MEDICUS_PATHOGEN_SALMONELLA_SOPE_E2_TO_NOD_NFKB_SIGNALING_PATHWAY	RELA NFKB1	1.26e-03	9	85	2	M47734
Pathway	BIOCARTA_PCAF_PATHWAY	RELA NFKB1	1.26e-03	9	85	2	MM1533
Pathway	WP_SUPPRESSION_OF_HMGB1MEDIATED_INFLAMMATION_BY_THBD	RELA NFKB1	1.26e-03	9	85	2	M39509
Pathway	REACTOME_INTERLEUKIN_1_PROCESSING	RELA NFKB1	1.26e-03	9	85	2	M27383
Pathway	KEGG_MEDICUS_REFERENCE_NOD_NFKB_SIGNALING_PATHWAY	RELA NFKB1	1.26e-03	9	85	2	M47652
Pathway	REACTOME_INTERLEUKIN_1_PROCESSING	RELA NFKB1	1.26e-03	9	85	2	MM15129
Pathway	WP_NEOVASCULARIZATION_PROCESSES	RELA NFKB1 MAPK3	1.42e-03	37	85	3	M39506
Pathway	WP_MELATONIN_METABOLISM_AND_EFFECTS	CYP2C19 SIRT1 NFKB1	1.42e-03	37	85	3	M39418
Pathway	REACTOME_NCAM_SIGNALING_FOR_NEURITE_OUT_GROWTH	COL5A2 SPTBN5 MAPK3	1.53e-03	38	85	3	MM14969
Pathway	BIOCARTA_RNA_PATHWAY	RELA NFKB1	1.57e-03	10	85	2	M10570
Pathway	REACTOME_REGULATED_PROTEOLYSIS_OF_P75NTR	RELA NFKB1	1.57e-03	10	85	2	MM14744
Pathway	KEGG_MEDICUS_REFERENCE_LIGHT_HVEM_NFKB_SIGNALING_PATHWAY	RELA NFKB1	1.57e-03	10	85	2	M47599
Pathway	BIOCARTA_FREE_PATHWAY	RELA NFKB1	1.57e-03	10	85	2	M96
Pathway	KEGG_MEDICUS_REFERENCE_TLR3_NFKB_SIGNALING_PATHWAY	RELA NFKB1	1.57e-03	10	85	2	M47601
Pathway	WP_IL1_SIGNALING_PATHWAY	RELA NFKB1 MAPK3	1.65e-03	39	85	3	MM15996
Pathway	PID_RET_PATHWAY	SHANK3 MAPK3 GAB1	1.65e-03	39	85	3	M82
Pathway	WP_IL2_SIGNALING_PATHWAY	RELA NFKB1 MAPK3 IL2RA	1.87e-03	87	85	4	MM15915
Pathway	WP_INCLUSION_BODY_MYOSITIS	SIRT1 NFKB1	1.91e-03	11	85	2	M42545
Pathway	BIOCARTA_EPONFKB_PATHWAY	RELA NFKB1	1.91e-03	11	85	2	MM1393
Pathway	REACTOME_REGULATED_PROTEOLYSIS_OF_P75NTR	RELA NFKB1	1.91e-03	11	85	2	M2661
Pathway	KEGG_MEDICUS_ENV_FACTOR_NNK_NNN_TO_PI3K_SIGNALING_PATHWAY_N01339	RELA NFKB1	1.91e-03	11	85	2	M47791
Pathway	WP_NAD_METABOLISM_SIRTUINS_AND_AGING	SIRT1 NFKB1	1.91e-03	11	85	2	M39439
Pathway	KEGG_MEDICUS_PATHOGEN_EBV_LMP1_TO_NFKB_SIGNALING_PATHWAY	RELA NFKB1	1.91e-03	11	85	2	M47493
Pathway	BIOCARTA_EPONFKB_PATHWAY	RELA NFKB1	1.91e-03	11	85	2	M6917
Pathway	REACTOME_RND3_GTPASE_CYCLE	SEMA4F ARHGAP5 WDR6	2.05e-03	42	85	3	M41826
Pathway	REACTOME_RND3_GTPASE_CYCLE	SEMA4F ARHGAP5 WDR6	2.05e-03	42	85	3	MM15677
Pathway	BIOCARTA_TCR_PATHWAY	RELA NFKB1 MAPK3	2.05e-03	42	85	3	MM1504
Pathway	WP_TNFRELATED_WEAK_INDUCER_OF_APOPTOSIS_TWEAK_SIGNALING	RELA NFKB1 MAPK3	2.05e-03	42	85	3	M39452
Pubmed	Synaptic GAP and GEF Complexes Cluster Proteins Essential for GTP Signaling.	DMXL2 SYNE1 KCNAB2 SRCIN1 ARHGAP39 SHANK3 UBR5 GNAS MAPK3 AGAP7P AGAP4 AGAP6	2.44e-10	281	118	12	28706196
Pubmed	A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome.	KANSL1L DMXL2 MYCBP2 HEBP2 PEG10 SYNE1 GON4L ZNF407 KMT2E DHX15 LARP4B ZNF592 PLCE1	1.58e-08	497	118	13	23414517
Pubmed	The ING4 tumor suppressor attenuates NF-kappaB activity at the promoters of target genes.	RELA NFKB1 ING4	3.81e-08	3	118	3	18779315
Pubmed	Primate segmental duplication creates novel promoters for the LRRC37 gene family within the 17q21.31 inversion polymorphism region.	LRRC37A3 LRRC37A2 LRRC37A	1.52e-07	4	118	3	22419166
Pubmed	Nuclear factor-kappaB p65 inhibits mitogen-activated protein kinase signaling pathway in radioresistant breast cancer cells.	RELA NFKB1 MAPK3	7.56e-07	6	118	3	17189385
Pubmed	NF-kappaB-dependent transcriptional activation in lung carcinoma cells by farnesol involves p65/RelA(Ser276) phosphorylation via the MEK-MSK1 signaling pathway.	RELA NFKB1 MAPK3	1.32e-06	7	118	3	18424438
Pubmed	A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.	CYP2C18 SIRT1 CCDC7 SEPHS1 SEC23IP CCSER2 KNDC1 KAT6B IL2RA PLCE1	1.63e-06	415	118	10	16385451
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	DGCR2 LMTK2 SRCIN1 TSR1 ZNF592 MDC1 CCSER2 AGAP7P KAT6B AGAP4 AGAP6	2.01e-06	529	118	11	14621295
Pubmed	Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.	MYCBP2 LMTK2 LARP4B UBR5 ZNF592 WDR6 MDC1 CCSER2 SMG9 NOP2	2.74e-06	440	118	10	34244565
Pubmed	GGAPs, a new family of bifunctional GTP-binding and GTPase-activating proteins.	AGAP7P AGAP4 AGAP6	3.15e-06	9	118	3	12640130
Pubmed	HIV-1 Tat protein induces TNF-alpha and IL-10 production by human macrophages: differential implication of PKC-betaII and -delta isozymes and MAP kinases ERK1/2 and p38.	RELA NFKB1 MAPK3	3.15e-06	9	118	3	18692180
Pubmed	Rac/ROS-related protein kinase C and phosphatidylinositol-3-kinase signaling are involved in a negative regulating cascade in B cell activation by antibody-mediated cross-linking of MHC class II molecules.	RELA NFKB1 MAPK3	3.15e-06	9	118	3	19939451
Pubmed	Functional genomic landscape of cancer-intrinsic evasion of killing by T cells.	ATP7A ATG13 ZNF407 RELA RETREG3 CCNH SEPHS1 EIF5 SMG9 GNAS	3.83e-06	457	118	10	32968282
Pubmed	Pro-inflammatory and pro-oxidant properties of the HIV protein Tat in a microglial cell line: attenuation by 17 beta-estradiol.	RELA NFKB1 MAPK3	4.49e-06	10	118	3	11579140
Pubmed	Evolutionary dynamism of the primate LRRC37 gene family.	LRRC37A3 LRRC37A2 LRRC37A	4.49e-06	10	118	3	23064749
Pubmed	Human immunodeficiency virus type 1 (HIV-1) tat induces nitric-oxide synthase in human astroglia.	RELA NFKB1 MAPK3	4.49e-06	10	118	3	12167619
Pubmed	AGAP1/AP-3-dependent endocytic recycling of M5 muscarinic receptors promotes dopamine release.	AGAP7P AGAP4 AGAP6	4.49e-06	10	118	3	20664521
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	DMXL2 MYCBP2 SYNE1 KCNAB2 BCL11A ARHGAP39 SHANK3 KIF15 UBR5 SEC23IP MAPK3 NOP2 UNC79 GOLGB1	5.13e-06	963	118	14	28671696
Pubmed	AGAP1, a novel binding partner of nitric oxide-sensitive guanylyl cyclase.	AGAP7P AGAP4 AGAP6	6.16e-06	11	118	3	15381706
Pubmed	A BioID-Derived Proximity Interactome for SARS-CoV-2 Proteins.	DGCR2 SPAG1 ATP7A SLC38A9 SYNE1 ANGEL1 ARHGAP39 PLEKHA6 UBR5 WDR6 SEC23IP PEAK1	6.44e-06	719	118	12	35337019
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	DMXL2 KIAA0586 NTNG1 ZNF407 ARHGAP39 PLEKHA6 SHANK3 LARP4B PEAK1 TMCC1	7.44e-06	493	118	10	15368895
Pubmed	Signaling pathways triggered by HIV-1 Tat in human monocytes to induce TNF-alpha.	RELA NFKB1 MAPK3 PLCE1	8.50e-06	38	118	4	12482669
Pubmed	The Endosome Localized Arf-GAP AGAP1 Modulates Dendritic Spine Morphology Downstream of the Neurodevelopmental Disorder Factor Dysbindin.	AGAP7P AGAP4 AGAP6	1.06e-05	13	118	3	27713690
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	DGCR2 DMXL2 ATP7A MYCBP2 PEG10 SYNE1 SIRT1 UBR5 TSR1 WDR6 CCSER2 GNAS PEAK1 NOP2 TMCC1 GOLGB1 GAB1	1.14e-05	1487	118	17	33957083
Pubmed	SIRT1 overexpression decreases cisplatin-induced acetylation of NF-κB p65 subunit and cytotoxicity in renal proximal tubule cells.	RELA SIRT1	1.14e-05	2	118	2	22330808
Pubmed	[Correlative study of nuclear factor-kappa B activity and cytokine expression in chronic sinusitis].	RELA NFKB1	1.14e-05	2	118	2	16408727
Pubmed	Trichomonas vaginalis inhibits proinflammatory cytokine production in macrophages by suppressing NF-kappaB activation.	RELA NFKB1	1.14e-05	2	118	2	15528993
Pubmed	NMR characterization of a 72 kDa transcription factor using differential isotopic labeling.	RELA NFKB1	1.14e-05	2	118	2	26647230
Pubmed	Functionally distinct NF-kappa B binding sites in the immunoglobulin kappa and IL-2 receptor alpha chain genes.	NFKB1 IL2RA	1.14e-05	2	118	2	2497520
Pubmed	Kinetic enhancement of NF-kappaBxDNA dissociation by IkappaBalpha.	RELA NFKB1	1.14e-05	2	118	2	19887633
Pubmed	SIRT1 promotes the central adaptive response to diet restriction through activation of the dorsomedial and lateral nuclei of the hypothalamus.	SIRT1 CCDC7	1.14e-05	2	118	2	20668205
Pubmed	Inhibiting sphingosine kinase 2 mitigates mutant Huntingtin-induced neurodegeneration in neuron models of Huntington disease.	KCNN2 HTT	1.14e-05	2	118	2	28175299
Pubmed	Transcription factor NF-κB (p50/p50, p65/p65) controls porcine ovarian cells functions.	RELA NFKB1	1.14e-05	2	118	2	21996578
Pubmed	Sirtuin regulates cigarette smoke-induced proinflammatory mediator release via RelA/p65 NF-kappaB in macrophages in vitro and in rat lungs in vivo: implications for chronic inflammation and aging.	RELA SIRT1	1.14e-05	2	118	2	17041012
Pubmed	S-phase-dependent p50/NF-кB1 phosphorylation in response to ATR and replication stress acts to maintain genomic stability.	RELA NFKB1	1.14e-05	2	118	2	25590437
Pubmed	NF-κB Rel subunit exchange on a physiological timescale.	RELA NFKB1	1.14e-05	2	118	2	34089216
Pubmed	TF-PROTACs Enable Targeted Degradation of Transcription Factors.	RELA NFKB1	1.14e-05	2	118	2	34100597
Pubmed	NO-donating aspirin inhibits the activation of NF-kappaB in human cancer cell lines and Min mice.	RELA NFKB1	1.14e-05	2	118	2	18174252
Pubmed	AXL confers cell migration and invasion by hijacking a PEAK1-regulated focal adhesion protein network.	AXL PEAK1	1.14e-05	2	118	2	32681075
Pubmed	Akt is a downstream target of NF-kappa B.	RELA NFKB1	1.14e-05	2	118	2	12052823
Pubmed	Few alterations in clinical pathology and histopathology observed in a CYP2C18&19 humanized mice model.	CYP2C19 CYP2C18	1.14e-05	2	118	2	19038035
Pubmed	Sustained oscillations of NF-kappaB produce distinct genome scanning and gene expression profiles.	RELA NFKB1	1.14e-05	2	118	2	19787057
Pubmed	NF-κB Has a Direct Role in Inhibiting Bmp- and Wnt-Induced Matrix Protein Expression.	RELA NFKB1	1.14e-05	2	118	2	26179215
Pubmed	NF-kappaB p50 and p65 subunits control intestinal homeostasis.	RELA NFKB1	1.14e-05	2	118	2	17705134
Pubmed	SIRT1 longevity factor suppresses NF-kappaB -driven immune responses: regulation of aging via NF-kappaB acetylation?	RELA SIRT1	1.14e-05	2	118	2	18800364
Pubmed	The p50-p50 NF-kappaB complex as a stimulus-specific repressor of gene activation.	RELA NFKB1	1.14e-05	2	118	2	15543947
Pubmed	A role for NF-kappa B subunits p50 and p65 in the inhibition of lipopolysaccharide-induced shock.	RELA NFKB1	1.14e-05	2	118	2	15494531
Pubmed	Dysregulated apoptosis and NFkappaB expression in COPD subjects.	RELA NFKB1	1.14e-05	2	118	2	19296848
Pubmed	Activation of the NF-kappaB signalling pathway in diffuse large B-cell lymphoma: clinical implications.	RELA NFKB1	1.14e-05	2	118	2	18983609
Pubmed	Typhlocolitis in NF-kappa B-deficient mice.	RELA NFKB1	1.14e-05	2	118	2	11160181
Pubmed	SIRT1 suppresses the migration and invasion of gastric cancer by regulating ARHGAP5 expression.	SIRT1 ARHGAP5	1.14e-05	2	118	2	30250020
Pubmed	Expression of the GTP-binding protein (Galphas) is repressed by the nuclear factor kappaB RelA subunit in human myometrium.	RELA GNAS	1.14e-05	2	118	2	16081638
Pubmed	A novel form of NF-kappaB is induced by Leishmania infection: involvement in macrophage gene expression.	RELA NFKB1	1.14e-05	2	118	2	18383035
Pubmed	Genome-wide association study of bipolar disorder in Canadian and UK populations corroborates disease loci including SYNE1 and CSMD1.	SYNE1 CSMD1	1.14e-05	2	118	2	24387768
Pubmed	Epigenetic Regulation of KPC1 Ubiquitin Ligase Affects the NF-κB Pathway in Melanoma.	RNF123 NFKB1	1.14e-05	2	118	2	28389511
Pubmed	Characterization of a functional NF-kappa B site in the human interleukin 1 beta promoter: evidence for a positive autoregulatory loop.	RELA NFKB1	1.14e-05	2	118	2	8413223
Pubmed	Herpes Simplex Virus 1 UL24 Abrogates the DNA Sensing Signal Pathway by Inhibiting NF-κB Activation.	RELA NFKB1	1.14e-05	2	118	2	28100608
Pubmed	High expression of RelA/p65 is associated with activation of nuclear factor-kappaB-dependent signaling in pancreatic cancer and marks a patient population with poor prognosis.	RELA NFKB1	1.14e-05	2	118	2	17622249
Pubmed	Modulation of NF-kappaB-dependent transcription and cell survival by the SIRT1 deacetylase.	RELA SIRT1	1.14e-05	2	118	2	15152190
Pubmed	DNA binding and I kappa B inhibition of the cloned p65 subunit of NF-kappa B, a rel-related polypeptide.	RELA NFKB1	1.14e-05	2	118	2	2001591
Pubmed	The kappa B DNA sequence from the HIV long terminal repeat functions as an allosteric regulator of HIV transcription.	RELA NFKB1	1.14e-05	2	118	2	11970949
Pubmed	Synaptic activation of NF-kappa B by glutamate in cerebellar granule neurons in vitro.	RELA NFKB1	1.14e-05	2	118	2	7568076
Pubmed	Transcriptional regulation of cyclooxygenase 2 by bradykinin and interleukin-1beta in human airway smooth muscle cells: involvement of different promoter elements, transcription factors, and histone h4 acetylation.	RELA NFKB1	1.14e-05	2	118	2	14645533
Pubmed	Inactivation of Sirt1 in mouse livers protects against endotoxemic liver injury by acetylating and activating NF-κB.	SIRT1 NFKB1	1.14e-05	2	118	2	27711079
Pubmed	A short binding site in the KPC1 ubiquitin ligase mediates processing of NF-κB1 p105 to p50: A potential for a tumor-suppressive PROTAC.	RNF123 NFKB1	1.14e-05	2	118	2	34873064
Pubmed	[Lipopolysaccharide and hyperoxia induce nuclear factor-kappa B expression in human embryo lung fibroblasts in vitro].	RELA NFKB1	1.14e-05	2	118	2	18947494
Pubmed	Melatonin reverses H2 O2 -induced senescence in SH-SY5Y cells by enhancing autophagy via sirtuin 1 deacetylation of the RelA/p65 subunit of NF-κB.	RELA SIRT1	1.14e-05	2	118	2	28295567
Pubmed	[Study on the nuclear translocation mechanism in the inhibition of nuclear factor-ΚB activation in bacterial lipoprotein-tolerant THP-1 cells].	RELA NFKB1	1.14e-05	2	118	2	21549062
Pubmed	Resveratrol inhibits the progression of premature senescence partially by regulating v-rel avian reticuloendotheliosis viral oncogene homolog A (RELA) and sirtuin 1 (SIRT1).	RELA SIRT1	1.14e-05	2	118	2	35166167
Pubmed	Lowered expressions of the NF-kappaB family members in dendritic cells from NOD mice are associated with a reduced expression of GATA-2.	GATA2 RELA	1.14e-05	2	118	2	19120268
Pubmed	Crystal structure of p50/p65 heterodimer of transcription factor NF-kappaB bound to DNA.	RELA NFKB1	1.14e-05	2	118	2	9450761
Pubmed	Structural basis of HIV-1 activation by NF-kappaB--a higher-order complex of p50:RelA bound to the HIV-1 LTR.	RELA NFKB1	1.14e-05	2	118	2	19683540
Pubmed	Shear stress inhibits smooth muscle cell-induced inflammatory gene expression in endothelial cells: role of NF-kappaB.	RELA NFKB1	1.14e-05	2	118	2	15718492
Pubmed	[Role of oxidized low-density lipoprotein in NF-κB signal pathway].	RELA NFKB1	1.14e-05	2	118	2	24321067
Pubmed	SIRT1 inhibits rheumatoid arthritis fibroblast-like synoviocyte aggressiveness and inflammatory response via suppressing NF-κB pathway.	RELA SIRT1	1.14e-05	2	118	2	29784872
Pubmed	An evaluation of anti-TNF-alpha-therapy in patients with ankylosing spondylitis: imbalanced activation of NF kappa B subunits in lymphocytes and modulation of serum cortisol concentration.	RELA NFKB1	1.14e-05	2	118	2	17242904
Pubmed	Prevention of cardiac hypertrophy and heart failure by silencing of NF-kappaB.	RELA NFKB1	1.14e-05	2	118	2	18037434
Pubmed	Dual knockdown of p65 and p50 subunits of NF-kappaB by siRNA inhibits the induction of inflammatory cytokines and significantly enhance apoptosis in human primary synoviocytes treated with tumor necrosis factor-alpha.	RELA NFKB1	1.14e-05	2	118	2	17530443
Pubmed	NF-kappaB activation in premalignant mouse tal-1/scl thymocytes and tumors.	RELA NFKB1	1.14e-05	2	118	2	12816868
Pubmed	Addressing reported pro-apoptotic functions of NF-kappaB: targeted inhibition of canonical NF-kappaB enhances the apoptotic effects of doxorubicin.	RELA NFKB1	1.14e-05	2	118	2	19746155
Pubmed	Estrogen withdrawal-induced NF-kappaB activity and bcl-3 expression in breast cancer cells: roles in growth and hormone independence.	RELA NFKB1	1.14e-05	2	118	2	12972607
Pubmed	The metal nanoparticle-induced inflammatory response is regulated by SIRT1 through NF-κB deacetylation in aseptic loosening.	SIRT1 NFKB1	1.14e-05	2	118	2	28553103
Pubmed	Glutathione supplementation potentiates hypoxic apoptosis by S-glutathionylation of p65-NFkappaB.	RELA NFKB1	1.14e-05	2	118	2	17468103
Pubmed	Vaccinia virus inhibits NF-κB-dependent gene expression downstream of p65 translocation.	RELA NFKB1	1.14e-05	2	118	2	24371075
Pubmed	Multiple NF-κB sites in HIV-1 subtype C long terminal repeat confer superior magnitude of transcription and thereby the enhanced viral predominance.	RELA NFKB1	1.14e-05	2	118	2	23132857
Pubmed	Comparative expression of NFkappaB proteins in melanocytes of normal skin vs. benign intradermal naevus and human metastatic melanoma biopsies.	RELA NFKB1	1.14e-05	2	118	2	15016307
Pubmed	A SNP in the HTT promoter alters NF-κB binding and is a bidirectional genetic modifier of Huntington disease.	NFKB1 HTT	1.14e-05	2	118	2	25938884
Pubmed	Role of NF-kappaB in the antiproliferative effect of endothelin-1 and tumor necrosis factor-alpha in human hepatic stellate cells. Involvement of cyclooxygenase-2.	RELA NFKB1	1.14e-05	2	118	2	9722548
Pubmed	Evidence that CYP2C19 is the major (S)-mephenytoin 4'-hydroxylase in humans.	CYP2C19 CYP2C18	1.14e-05	2	118	2	8110777
Pubmed	Pre-labour fetal membranes overlying the cervix display alterations in inflammation and NF-kappaB signalling pathways.	RELA NFKB1	1.14e-05	2	118	2	18952281
Pubmed	Nuclear factor-kappa B nuclear translocation in the cochlea of mice following acoustic overstimulation.	RELA NFKB1	1.14e-05	2	118	2	16376312
Pubmed	Gastroenteritis in NF-kappaB-deficient mice is produced with wild-type Camplyobacter jejuni but not with C. jejuni lacking cytolethal distending toxin despite persistent colonization with both strains.	RELA NFKB1	1.14e-05	2	118	2	14742559
Pubmed	Sirt1 protects against intervertebral disc degeneration induced by 1,25-dihydroxyvitamin D insufficiency in mice by inhibiting the NF-κB inflammatory pathway.	RELA SIRT1	1.14e-05	2	118	2	37200907
Pubmed	Mitogenic and antiapoptotic role of constitutive NF-kappaB/Rel activity in pancreatic cancer.	RELA NFKB1	1.14e-05	2	118	2	12767057
Pubmed	Active repression of antiapoptotic gene expression by RelA(p65) NF-kappa B.	RELA NFKB1	1.14e-05	2	118	2	15053878
Pubmed	Herpes simplex virus 1 DNA polymerase processivity factor UL42 inhibits TNF-α-induced NF-κB activation by interacting with p65/RelA and p50/NF-κB1.	RELA NFKB1	1.14e-05	2	118	2	23636254
Pubmed	Co-expression of NF-κB-p65 and phosphorylated NF-κB-p105 is associated with poor prognosis in surgically resectable non-small cell lung cancer.	RELA NFKB1	1.14e-05	2	118	2	29363879
Pubmed	Identification of gene function and functional pathways by systemic plasmid-based ribozyme targeting in adult mice.	RELA NFKB1	1.14e-05	2	118	2	11891271
Pubmed	A requirement for nuclear factor-kappaB in developmental and plasticity-associated synaptogenesis.	RELA NFKB1	1.14e-05	2	118	2	21471377
Pubmed	Divergent gene regulation and growth effects by NF-kappa B in epithelial and mesenchymal cells of human skin.	RELA NFKB1	1.14e-05	2	118	2	12673201
Interaction	EIF3I interactions	ATG13 ANGEL1 UBR5 TSR1 NFKB1 B3GNT2 EIF5 EIF3D PSPC1 HTT	2.47e-06	258	116	10	int:EIF3I
Cytoband	18q23	SALL3 ZNF407 CTDP1	5.76e-05	29	118	3	18q23
GeneFamily	Ankyrin repeat domain containing\|NF-kappa B complex subunits	RELA NFKB1	2.16e-04	5	85	2	1254
GeneFamily	Cyclins	CCNH CCNYL1 CCNYL2	3.02e-04	28	85	3	473
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	PLEKHA6 OSBPL7 AGAP7P AGAP4 AGAP6 GAB1	4.21e-04	206	85	6	682
GeneFamily	ArfGAPs	AGAP7P AGAP4 AGAP6	4.94e-04	33	85	3	395
GeneFamily	PHD finger proteins	ING5 KMT2E ING4 KAT6B	8.55e-04	90	85	4	88
GeneFamily	X-linked mental retardation\|Rho GTPase activating proteins\|BAR-PH domain containing	AGAP4 AGAP6	2.84e-03	17	85	2	1291
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD8_c01-LEF1\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	ATP7A ZNF407 CCDC7 HABP4 CTDP1 CCSER2	4.53e-06	161	118	6	5fba13f0aa5002f7eefe219e2c6a07e163f1a50d
ToppCell	TCGA-Brain-Primary_Tumor-Low_Grade_Glioma\|TCGA-Brain / Sample_Type by Project: Shred V9	DGCR2 TSPOAP1 SYNE1 CCSER2 KAT6B GOLGB1	7.79e-06	177	118	6	e8ab340b20cd41554c3841fe980e078e878af35f
ToppCell	droplet-Heart-nan-3m-Neuronal-cardiac_neuron\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SEMA4F NTNG1 PTPRZ1 KCNK5 CSMD1 PLCE1	8.58e-06	180	118	6	da723df348d7b8449bb1124f23fe6fa706412adb
ToppCell	droplet-Heart-nan-3m-Neuronal\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SEMA4F NTNG1 PTPRZ1 KCNK5 CSMD1 PLCE1	8.58e-06	180	118	6	5b146a94708b3c3610542a4d0925f3f7a2b19185
ToppCell	droplet-Heart-nan-3m-Neuronal-cardiac_neuron\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SEMA4F NTNG1 PTPRZ1 KCNK5 CSMD1 PLCE1	8.58e-06	180	118	6	50758b1e7be2e43f83c10ab106900c067e61f5f7
ToppCell	368C-Epithelial_cells-Epithelial-B_(AT2)\|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)	TSPOAP1 KCNAB2 SIRT1 AGAP4 AGAP6	9.78e-06	107	118	5	410b37beffaf637a2a64c9d0ce7baf81f4bc667c
ToppCell	368C-Epithelial_cells-Epithelial-B_(AT2)-\|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)	TSPOAP1 KCNAB2 SIRT1 AGAP4 AGAP6	9.78e-06	107	118	5	5bae4b3aede9bcbf7e88414e3453973cc8b0c3e7
ToppCell	droplet-Heart-HEART-1m-Neuronal-nan\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SEMA4F PEG10 SRCIN1 PTPRZ1 KCNK5 CSMD1	1.03e-05	186	118	6	fddc6b93f98b10aaf8d4ebc142b46d8213f3129d
ToppCell	HSPCs-Ery/Mk_prog.\|World / Lineage and Cell class	KANSL1L GATA2 BCL11A IER2 MPP4 NFKB1	1.10e-05	188	118	6	5390089213cd6ee90dcdfd3c3f5b6765376cccf2
ToppCell	droplet-Heart-HEART-1m-Neuronal-cardiac_neuron\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SEMA4F SRCIN1 ARHGAP39 PTPRZ1 KCNK5 CSMD1	1.10e-05	188	118	6	921a2c9212a0f2a00fd72c594d80924f27e8b9b7
ToppCell	droplet-Heart-HEART-1m-Neuronal\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SEMA4F SRCIN1 ARHGAP39 PTPRZ1 KCNK5 CSMD1	1.13e-05	189	118	6	a618a1ddf5097a010c6c2c7341f3a0bd46a29c02
ToppCell	droplet-Heart-HEART-1m-Neuronal-cardiac_neuron\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SEMA4F SRCIN1 ARHGAP39 PTPRZ1 KCNK5 CSMD1	1.13e-05	189	118	6	4e61f9cd1c06bddb47ebf98affc0f97770e26e8c
ToppCell	Children_(3_yrs)-Endothelial-alveolar_capillary_endothelial_cell_(Cap2;_aerocyte)-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	PALD1 FAT4 SYNE1 GATA2 SHANK3 KCNN2	1.17e-05	190	118	6	0e9847d7f49b2236b8a191e1a7df37556351ba9e
ToppCell	Children_(3_yrs)-Endothelial-alveolar_capillary_endothelial_cell_(Cap2;_aerocyte)\|Children_(3_yrs) / Lineage, Cell type, age group and donor	PALD1 FAT4 SYNE1 GATA2 SHANK3 KCNN2	1.20e-05	191	118	6	f229abf69a1217194f74b0502486907e07dba989
ToppCell	Control-Myeloid-cDC2\|Myeloid / Disease state, Lineage and Cell class	PALD1 AXL BCL11A ARHGAP5 NFKB1 CSMD1	1.27e-05	193	118	6	4cb938c346cc32ec122d11e6b9f25db20e0f7ff6
ToppCell	390C-Epithelial_cells-Epithelial-I_(AT1)\|390C / Donor, Lineage, Cell class and subclass (all cells)	PEG10 LRRC37A2 ZNF407 ARHGAP5 UBR5 KAT6B	1.31e-05	194	118	6	88db9f9e80c20ff3474f1f6459dcbdc25aec0b6d
ToppCell	390C-Epithelial_cells-Epithelial-I_(AT1)-\|390C / Donor, Lineage, Cell class and subclass (all cells)	PEG10 LRRC37A2 ZNF407 ARHGAP5 UBR5 KAT6B	1.31e-05	194	118	6	a71728202493d4858342ea2756ea281cd0d99a3a
ToppCell	Parenchymal-NucSeq\|Parenchymal / Cell types per location group and 10X technology with lineage, and cell group designations	KANSL1L LRRC37A3 ZNF407 PEAK1 TMCC1 GAB1	1.47e-05	198	118	6	1996373bdccc55aac347d349bd22f6aad6d0c668
ToppCell	5'-Parenchyma_lung-Endothelial-Blood_vessel_EC-capillary_endothelial_cell-EC_aerocyte_capillary-EC_aerocyte_capillary_L.2.0.1.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	PALD1 SYNE1 GATA2 SHANK3 KCNN2 ARRDC2	1.56e-05	200	118	6	3767abc75176779198505ebc6967d55ce322d9fe
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_B-Plasma_cell-B_c05-MZB1-XBP1\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	PALD1 SALL3 HID1 KCNN2 GAB1	5.82e-05	155	118	5	881422c57d230c0e2e5f9098ab888caa94ca61aa
ToppCell	356C-Lymphocytic-CD4_T-cell-Treg_cell_4\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	DBF4B KCNK5 MAPK3 SPINDOC IL2RA	6.76e-05	160	118	5	c2b5fadb4bac17fafc08831f6d3f4ff96ada7e70
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c09-SLC4A10\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	SYNE1 CCNH TSR1 CTDP1 OSBPL7	7.60e-05	164	118	5	a5227971a71345854e0538e42da684de87febda0
ToppCell	368C-Endothelial_cells-Endothelial-C_(Capillary_Aerocyte_)\|368C / Donor, Lineage, Cell class and subclass (all cells)	PALD1 GATA2 HID1 SHANK3 KCNN2	8.05e-05	166	118	5	30a991fc3275b571d53bd0976df4789e5d40b01d
ToppCell	TCGA-Ovary-Primary_Tumor-Ovarian_Carcinoma-Serous_Cystadenocarcinoma-5\|TCGA-Ovary / Sample_Type by Project: Shred V9	KANSL1L GON4L KMT2E RNF123 WDR6	8.05e-05	166	118	5	32d2eaf8a5d03881bf74d680825af2d5110b082d
ToppCell	368C-Endothelial_cells-Endothelial-C_(Capillary_Aerocyte_)-\|368C / Donor, Lineage, Cell class and subclass (all cells)	PALD1 GATA2 HID1 SHANK3 KCNN2	8.05e-05	166	118	5	76b4cd32698900797ec009f17e50ea7ae36b85f4
ToppCell	3'_v3-lymph-node_spleen-Lymphocytic_T_CD4-T_CD4/CD8\|lymph-node_spleen / Manually curated celltypes from each tissue	SYNE1 ZNF407 NFKB1 KAT6B GOLGB1	9.25e-05	171	118	5	2e9a20f8980b78325c52065a9c14ab3656267c05
ToppCell	droplet-Limb_Muscle-MUSCLE-1m-Lymphocytic-unknown\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SPAG1 SRCIN1 TIGD2 KCNN2 ARRDC2	1.00e-04	174	118	5	6987fe7959afce347282f632abc16d800ccab7c4
ToppCell	ASK428-Immune-B_cell\|ASK428 / Donor, Lineage and Cell class of Lung cells from Dropseq	DBF4B HDX HID1 BCL11A CSMD1	1.00e-04	174	118	5	b5a7a612a515736cf3489afd0f6ad2054d54526f
ToppCell	ASK428-Immune-B_cell\|Immune / Donor, Lineage and Cell class of Lung cells from Dropseq	DBF4B HDX HID1 BCL11A CSMD1	1.03e-04	175	118	5	e0979e5795a49b4e5c9b88e7fe6b7bda7a413a6c
ToppCell	3'-Child09-12-SmallIntestine-Hematopoietic-Myeloid-Mast_cell\|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	BMP2K GATA2 IER2 SLC8A3 MPP4	1.12e-04	178	118	5	c6704fcd21a9d2fe45679a1d998f04213b3bf224
ToppCell	droplet-Heart-4Chambers-21m-Neuronal-cardiac_neuron\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SEMA4F NTNG1 SRCIN1 PTPRZ1 CSMD1	1.12e-04	178	118	5	3e8aacb27ed1a3c3978e21dddddd0828f8000692
ToppCell	P28-Epithelial-epithelial_progenitor_cell-epithelial_unknown_3\|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	NTNG1 ARHGAP39 KIF15 PTPRZ1 CSMD1	1.18e-04	180	118	5	1e819c5c87704ec6535dfeaae56561895e239d07
ToppCell	droplet-Heart-HEART_(ALL_MINUS_AORTA)-30m-Neuronal-cardiac_neuron\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SEMA4F NTNG1 SRCIN1 PTPRZ1 CSMD1	1.18e-04	180	118	5	d9c9399df3e2d9f23dbbfffb6cbe8404bf01e2b7
ToppCell	droplet-Heart-HEART_(ALL_MINUS_AORTA)-30m-Neuronal\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SEMA4F NTNG1 SRCIN1 PTPRZ1 CSMD1	1.18e-04	180	118	5	dad458398683ff80a6e207bdc08e257d1bb757d6
ToppCell	COVID-19-Endothelial_cells-Capillary_endothelial_cells\|COVID-19 / group, cell type (main and fine annotations)	PALD1 SYNE1 GATA2 SHANK3 KCNN2	1.21e-04	181	118	5	c5f9c92af1384d9089c65afdf41c6feb8345a3ae
ToppCell	droplet-Heart-HEART_(ALL_MINUS_AORTA)-30m-Neuronal-cardiac_neuron\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SEMA4F NTNG1 SRCIN1 PTPRZ1 CSMD1	1.24e-04	182	118	5	812ff2a50a510b18d865e89465dba1754a08ef61
ToppCell	droplet-Kidney-nan-18m-Mesenchymal-podocyte\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SEMA4F NTNG1 CCNYL1 PTPRZ1 ARRDC2	1.24e-04	182	118	5	e3248d108b51c49ca2c978636e13017e23b53860
ToppCell	facs-Lung-3m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l25-31\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	SEMA4F NTNG1 PTPRZ1 CSMD1 GAB1	1.24e-04	182	118	5	a1c0e4090a9e7aa4941a40c817d178de144888b6
ToppCell	HSPCs-Ery/Mk_prog.\|HSPCs / Lineage and Cell class	KANSL1L GATA2 IER2 MPP4 NFKB1	1.27e-04	183	118	5	59cfb02143b6b54dfca7560562e064948f0340ca
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FAT4 CSMD1 DNAH9 UNC79 PLCE1	1.30e-04	184	118	5	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	COPD-Myeloid-cDC1\|World / Disease state, Lineage and Cell class	PALD1 TSPOAP1 BCL11A ARHGAP5 HABP4	1.30e-04	184	118	5	42d7ce104cd7bcb83fbbbd0e7d3267ad07edfa94
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c01-LEF1\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	DGCR2 ARHGAP5 HABP4 CCSER2 CACNA1I	1.30e-04	184	118	5	bd786db4dc4edae6d5cfc0b69901983dea19f729
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FAT4 CSMD1 DNAH9 UNC79 PLCE1	1.30e-04	184	118	5	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	Control-Neu_4\|World / 5 Neutrophil clusters in COVID-19 patients	DMXL2 KIAA0586 KCNAB2 GON4L HTT	1.30e-04	184	118	5	ce7f044956613118ee2e9fb6af2455c3166cb414
ToppCell	Serous\|World / shred by cell class for bronchial biopsy	PEG10 HID1 TMED3 KCNK5 GNAS	1.30e-04	184	118	5	09d0d1525c11dd326efd942684c03f79d992cf3b
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FAT4 CSMD1 DNAH9 UNC79 PLCE1	1.30e-04	184	118	5	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	Control-Lymphoid-ILC_A\|Lymphoid / Disease state, Lineage and Cell class	GATA2 LATS2 NFKB1 CTDP1 GAB1	1.34e-04	185	118	5	520795866d44def5be3910ce8e728045c716a24d
ToppCell	Mid-temporal_gyrus_(MTG)-Non-neuronal-Macroglial-Oligo-OPC-OPC_L1-6_MYT1\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	WSCD1 SALL3 NTNG1 PTPRZ1 PLCE1	1.34e-04	185	118	5	2e1766f1a972fecd670daaaf7eb2d3a404f121e7
ToppCell	Mid-temporal_gyrus_(MTG)-Non-neuronal-Macroglial-Oligo-OPC\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	WSCD1 SALL3 NTNG1 PTPRZ1 PLCE1	1.34e-04	185	118	5	7aaa8335b40927e3e8fdcede807cd521fc213a0d
ToppCell	356C-Endothelial_cells-Endothelial-C_(Capillary_Aerocyte_)-\|356C / Donor, Lineage, Cell class and subclass (all cells)	WSCD1 PALD1 GATA2 SHANK3 KCNN2	1.37e-04	186	118	5	f0b78c7ee20279970ea8961bf59acb5262f2dce5
ToppCell	356C-Endothelial_cells-Endothelial-C_(Capillary_Aerocyte_)\|356C / Donor, Lineage, Cell class and subclass (all cells)	WSCD1 PALD1 GATA2 SHANK3 KCNN2	1.37e-04	186	118	5	2b3c814a7dee8286ea113c63dc3de5daf0257d37
ToppCell	droplet-Bladder-nan\|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYCBP2 KMT2E IER2 ARHGAP5 GOLGB1	1.41e-04	187	118	5	663991a8afe652e92363b64bcbd68c14d0307f0e
ToppCell	Adult-Endothelial-alveolar_capillary_endothelial_cell_(Cap2;_aerocyte)\|Adult / Lineage, Cell type, age group and donor	PALD1 SYNE1 GATA2 SHANK3 KCNN2	1.44e-04	188	118	5	e5cad03f4a64147fe8174e7f614cf45233ffb9b7
ToppCell	nucseq-Endothelial-Endothelial_Vascular-Endothelial_capillary-CAP2\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	PALD1 SYNE1 GATA2 SHANK3 KCNN2	1.48e-04	189	118	5	b6b4da51bc7f2c13a2f940540fdc61027d084835
ToppCell	Control-Myeloid-cDC2\|Control / Disease state, Lineage and Cell class	PALD1 AXL BCL11A NFKB1 CSMD1	1.52e-04	190	118	5	4e481e42353d47af7991744000403af2873f6a41
ToppCell	3'_v3-Lung-Lymphocytic_NK-NK_CD56bright_CD16-\|Lung / Manually curated celltypes from each tissue	SPAG1 KMT2E IER2 NFKB1 CTDP1	1.55e-04	191	118	5	12ce360dc149c85d5a22cfc1bf53d54aef79edc1
ToppCell	COPD-Myeloid-cDC1\|Myeloid / Disease state, Lineage and Cell class	PALD1 TSPOAP1 BCL11A ARHGAP5 HABP4	1.55e-04	191	118	5	3480e6d27dd4291765bbbb2acdb6a2e4f02c8085
ToppCell	COPD-Myeloid-cDC1\|COPD / Disease state, Lineage and Cell class	PALD1 TSPOAP1 BCL11A ARHGAP5 HABP4	1.59e-04	192	118	5	bd3d00b094d92463b06023361a71240851a542b8
ToppCell	PBMC-Control-cDC_6\|Control / Compartment, Disease Groups and Clusters	IER2 CCNH NFKB1 EIF5 GOLGB1	1.59e-04	192	118	5	41a7201febb7d88a39e4ee64df04cce18c691df8
ToppCell	(6)_Endothelial-C_(Capillary_Aerocyte_)\|World / Lung cell shreds - cell class (v4) and cell subclass (v4)	PALD1 GATA2 HID1 SHANK3 KCNN2	1.63e-04	193	118	5	f7f2dc6aff02d096a282835094d26d12b3b73e61
ToppCell	nucseq-Immune-Immune_Myeloid-Myeloid_Dendritic\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	PALD1 AXL BCL11A NFKB1 CSMD1	1.67e-04	194	118	5	bde6830a281f7cd7fd1733e40a41ddd2673ba88e
ToppCell	PCW_13-14-Endothelial-Endothelial_immature-endo_immature_arterial1_(12)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	WSCD1 GATA2 HID1 SHANK3 KCNN2	1.67e-04	194	118	5	32ba2cf9b8726bc3c6e9dc24b54d22ff188bb12b
ToppCell	368C-Myeloid-Macrophage-M2-like_Macrophage_(MARCO_negative)\|Macrophage / Donor, Lineage, Cell class and subclass (all cells)	BMP2K SYNE1 ZNF358 OSBPL7 IL2RA	1.67e-04	194	118	5	58046894446cb250814252a23f60fdd59c114d77
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	CCNH ARHGAP5 HABP4 CCSER2 CACNA1I	1.67e-04	194	118	5	a44be2f021cfdd0fcdc698c3f04d66db7a1aa6c2
ToppCell	distal-Epithelial-Differentiating_Basal-3\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	PEG10 SRCIN1 BCL11A PTPRZ1 KCNK5	1.71e-04	195	118	5	3fe6e49a9161fc9e5160251e6932cb5378175a54
ToppCell	Smart-start-Cell-Wel_seq-Neoplastic-Differentiated-like-AC-like-AC-like-E\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	WSCD1 SPAG1 PEG10 PTPRZ1 MAP3K19	1.71e-04	195	118	5	32ec72103faccc9e37c0ecedff1998e7df6a19f6
ToppCell	3'_v3-blood-Lymphocytic_NK-NK_CD56bright_CD16-\|blood / Manually curated celltypes from each tissue	SPAG1 IER2 NFKB1 PEAK1 GAB1	1.71e-04	195	118	5	1470f562ebcfe7da367964ecfd6c7f43bcdb4a73
ToppCell	Bronchial-NucSeq\|Bronchial / Cell types per location group and 10X technology with lineage, and cell group designations	KANSL1L LRRC37A3 ZNF407 TMCC1 GAB1	1.75e-04	196	118	5	ab53c742866945545a92e2e61850d63c80d9a2a6
ToppCell	Control-Neu_4\|Control / 5 Neutrophil clusters in COVID-19 patients	KCNAB2 KIF15 B3GNT2 EIF3D HTT	1.75e-04	196	118	5	b8b7b54ca17a08fa775507bb22b1c7248ada8f40
ToppCell	COVID-19-lung-Capillary_Aerocytes\|COVID-19 / Disease (COVID-19 only), tissue and cell type	PALD1 SYNE1 GATA2 SHANK3 KCNN2	1.75e-04	196	118	5	49cc0a2b9739abad61dff7292ea0b14d28ff35c4
ToppCell	COVID-19-lung-Capillary_Aerocytes\|lung / Disease (COVID-19 only), tissue and cell type	PALD1 SYNE1 GATA2 SHANK3 KCNN2	1.75e-04	196	118	5	4ac4073380d939a73cec7413e9f3f5ef616d2924
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	COL5A2 FAT4 AXL SYNE1 PEAK1	1.79e-04	197	118	5	9b480f9c799a244bfee64487abd8a1bf07c9a3a2
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Glomerular_Capillary_Endothelial_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PALD1 FAT4 SYNE1 SHANK3 ARRDC2	1.84e-04	198	118	5	92416e65a0dc1a4bf931833407620ea05d362f56
ToppCell	mild_COVID-19_(asymptomatic)-NK\|World / disease group, cell group and cell class (v2)	WSCD1 FAT4 TSPOAP1 SYNE1 CCSER2	1.84e-04	198	118	5	7a0aac52d785037455e068e1b25de4b2bf0fff79
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	COL5A2 FAT4 AXL SYNE1 PEAK1	1.84e-04	198	118	5	a860246bcea847249a78fd2e86ed8e04371060db
ToppCell	5'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.2.1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SPAG1 HEBP2 DNAH9 GOLGB1 MAP3K19	1.84e-04	198	118	5	d0ecace1fad24ce50b0935036fabb07e6c9e372d
ToppCell	Bronchial-10x5prime-Endothelial-Endothelia_vascular-VE_alveolar_capillary_Car4_aerocyte\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	PALD1 GATA2 HID1 SHANK3 KCNN2	1.88e-04	199	118	5	7ed541309808f15d65a9c4b26be2050e077539e6
ToppCell	Fetal_brain-fetalBrain_Zhong_nature-GW23-OPC_related\|GW23 / Sample Type, Dataset, Time_group, and Cell type.	WSCD1 SALL3 NTNG1 KIF15 PTPRZ1	1.92e-04	200	118	5	439265194cb08d1373296bf8684cc31294cecb20
ToppCell	Parenchymal-10x3prime_v2-Epithelial-Epi_airway_basal-Suprabasal\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	FOXO6 BCL11A TIGD2 PTPRZ1 KCNK5	1.92e-04	200	118	5	924eacea513dde8e3bd805a335bc4285647b800d
ToppCell	Tracheal-10x3prime_v2-Stromal-Peri/Epineurial_\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	ZNF407 CCDC7 ZSCAN29 LATS2 GAB1	1.92e-04	200	118	5	f7c3a8f5ac156c05ad7335d6d142c154c7d86449
ToppCell	mild-NK_CD56bright\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	SPAG1 MDC1 PEAK1 KAT6B GAB1	1.92e-04	200	118	5	a195bc6784346f706d4cd5b740adac1d950ce88a
ToppCell	Fetal_brain-fetalBrain_Zhong_nature-GW23-OPC_related-OPC\|GW23 / Sample Type, Dataset, Time_group, and Cell type.	WSCD1 SALL3 NTNG1 KIF15 PTPRZ1	1.92e-04	200	118	5	0450a79c5fae5ccacdb990ae674e4734ef0c3691
Drug	Chlorpromazine hydrochloride [69-09-0]; Up 200; 11.2uM; HL60; HT_HG-U133A	TSPOAP1 KCNAB2 RELA CCSER2 EIF5 ING4 MAPK3 TMCC1	6.71e-06	193	116	8	1864_UP
Drug	5-hydroxy-6,8,11,14-eicosatetraenoic acid	RELA NFKB1 MAPK3	7.08e-06	8	116	3	ctd:C022022
Drug	Bee Venoms	RELA SIRT1 NFKB1 MAPK3	7.45e-06	25	116	4	ctd:D001514
Drug	Hydrochlorothiazide [58-93-5]; Down 200; 13.4uM; HL60; HG-U133A	DGCR2 KIAA0586 ANGEL1 GATA2 RNF123 SEC23IP KCNK5 KAT6B	7.51e-06	196	116	8	1987_DN
Drug	SC 19220; Down 200; 10uM; PC3; HT_HG-U133A	ANGEL1 GATA2 KCNAB2 LARP4B RNF123 B3GNT2 RNF216 TMCC1	8.09e-06	198	116	8	7095_DN
Drug	Pyrilamine maleate [59-33-6]; Down 200; 10uM; PC3; HT_HG-U133A	AXL BCL11A ZNF592 SEC23IP CCSER2 EIF5 ING4 TMCC1	8.09e-06	198	116	8	5869_DN
Drug	wortmannin from Penicillium funiculosum; Down 200; 0.01uM; HL60; HT_HG-U133A	SPAG1 BMP2K DBF4B ATG13 GATA2 BCL11A TSR1 ZNF592	8.09e-06	198	116	8	1184_DN
Drug	Reserpine [50-55-5]; Down 200; 6.6uM; MCF7; HT_HG-U133A	DGCR2 SEMA4F PLEKHA6 KIF15 EIF5 ING4 TMCC1 GOLGB1	8.39e-06	199	116	8	3341_DN
Drug	Melarsoprol	CYP2C19 RELA NFKB1	1.51e-05	10	116	3	ctd:D008549
Drug	sargachromanol G	RELA NFKB1 MAPK3	1.51e-05	10	116	3	ctd:C577249
Drug	soyasaponin Ab	RELA NFKB1 MAPK3	2.06e-05	11	116	3	ctd:C551307
Drug	WR 1065	RELA NFKB1 IL2RA	2.06e-05	11	116	3	ctd:C020174
Drug	prostaglandin E2 glyceryl ester	RELA NFKB1 MAPK3	2.06e-05	11	116	3	ctd:C518978
Drug	WR 33278	RELA NFKB1	2.57e-05	2	116	2	ctd:C045611
Drug	cudraflavone B	RELA SIRT1 MAPK3	2.74e-05	12	116	3	ctd:C542041
Drug	beta-ionone	RELA NFKB1 MAPK3	2.74e-05	12	116	3	ctd:C008157
Drug	irinotecan HCl; Down 200; 100uM; PC3; HT_HG-U133A	COL5A2 KIAA0586 LARP4B KIF15 UBR5 CCSER2 KAT6B	2.80e-05	171	116	7	7535_DN
Drug	treprostinil sodium	PALD1 ATP7A RELA NFKB1	4.13e-05	38	116	4	CID000054786
Drug	methoctramine	RELA NFKB1 MAPK3	4.50e-05	14	116	3	ctd:C054938
Drug	LY 294002; Down 200; 10uM; HL60; HT_HG-U133A	GATA2 GON4L BCL11A TSR1 SEC23IP KCNK5 KAT6B	5.29e-05	189	116	7	1168_DN
Drug	4-methylbenzaldehyde	RELA NFKB1 MAPK3	5.61e-05	15	116	3	ctd:C020627
Drug	Ofloxacin [82419-36-1]; Down 200; 11uM; HL60; HT_HG-U133A	TSPOAP1 ANGEL1 GATA2 ING4 RNF216 MAPK3 HTT	6.44e-05	195	116	7	2340_DN
Drug	Asiaticoside [16830-15-2]; Down 200; 4.2uM; MCF7; HT_HG-U133A	DGCR2 KIAA0586 SEC23IP CCSER2 EIF5 RNF216 HTT	6.44e-05	195	116	7	7004_DN
Drug	nordihydroguaiaretic acid; Up 200; 1uM; MCF7; HT_HG-U133A	DMXL2 PLEKHA6 ZNF358 KCNN2 ING4 GNAS PLCE1	6.65e-05	196	116	7	5583_UP
Drug	Coralyne chloride hydrate [38989-38-7]; Down 200; 9.6uM; PC3; HT_HG-U133A	DGCR2 AXL PLEKHA6 ZNF592 ZNF358 ING4 PLCE1	6.87e-05	197	116	7	6317_DN
Drug	Neomycin sulfate [1405-10-3]; Down 200; 4.2uM; PC3; HT_HG-U133A	PEG10 KIAA0586 BCL11A SEC23IP ING4 MAPK3 TMCC1	6.87e-05	197	116	7	5867_DN
Drug	Clostridium difficile lethal toxin B	RELA NFKB1 MAPK3	6.88e-05	16	116	3	ctd:C488583
Drug	12-Hydroxy-5,8,10,14-eicosatetraenoic Acid	RELA NFKB1 MAPK3	6.88e-05	16	116	3	ctd:D019377
Drug	Noscapine [128-62-1]; Up 200; 9.6uM; HL60; HG-U133A	BMP2K DBF4B RELA ING4 RNF216 GNAS TMCC1	7.09e-05	198	116	7	1753_UP
Drug	17-AAG; Down 200; 1uM; MCF7; HT_HG-U133A	DGCR2 SEMA4F BMP2K MYCBP2 KIAA0586 RNF123 CTDP1	7.09e-05	198	116	7	1650_DN
Drug	Iocetamic acid [16034-77-8]; Up 200; 6.6uM; MCF7; HT_HG-U133A	KANSL1L TSPOAP1 PEG10 ZNF407 OSBPL7 KCNN2 GAB1	7.09e-05	198	116	7	4425_UP
Drug	Cephalosporanic acid, 7-amino [957-68-6]; Up 200; 14.6uM; MCF7; HT_HG-U133A	KANSL1L COL5A2 BMP2K SPTBN5 CTDP1 ING4 GAB1	7.09e-05	198	116	7	3258_UP
Drug	Tolazoline hydrochloride [59-97-2]; Down 200; 20.4uM; MCF7; HT_HG-U133A	SEMA4F BMP2K GON4L PLEKHA6 FBXL5 LARP4B CTDP1	7.32e-05	199	116	7	1500_DN
Drug	Guanabenz acetate [23256-50-0]; Down 200; 13.8uM; HL60; HG-U133A	ATG13 KIAA0586 RNF123 B3GNT2 SMG9 MAPK3 HTT	7.32e-05	199	116	7	2045_DN
Drug	Kanamycin A sulfate [25389-94-0]; Down 200; 6.8uM; PC3; HT_HG-U133A	DGCR2 FAT4 BMP2K KCNAB2 GON4L BCL11A TMCC1	7.55e-05	200	116	7	4625_DN
Drug	B 581	RELA NFKB1	7.69e-05	3	116	2	ctd:C088459
Drug	quercetin 3-O-(2''-galloyl)glucopyranoside	RELA NFKB1	7.69e-05	3	116	2	ctd:C525669
Drug	heparin, O-desulfated	RELA NFKB1	7.69e-05	3	116	2	ctd:C410523
Drug	cyclopropapyrroloindole	RELA NFKB1	7.69e-05	3	116	2	ctd:C110747
Drug	4-(4-(5-nitrofuran-2-ylmethylene)-3, 5-dioxopyrazolidin-1-yl)benzoic acid ethyl ester	RELA MAPK3 IL2RA	8.32e-05	17	116	3	ctd:C000589317
Drug	butein	RELA SIRT1 NFKB1	8.32e-05	17	116	3	ctd:C040918
Drug	helenalin	ATP7A RELA NFKB1 EIF5 MAPK3	9.29e-05	89	116	5	CID000023205
Drug	artemisinine	CYP2C19 RELA NFKB1	9.94e-05	18	116	3	ctd:C031327
Drug	AC1L1DS5	RELA SIRT1 NFKB1 MAPK3	1.05e-04	48	116	4	CID000002483
Drug	pervanadate	RELA NFKB1 MAPK3	1.18e-04	19	116	3	ctd:C076715
Drug	zingerone	RELA NFKB1 MAPK3	1.18e-04	19	116	3	ctd:C013738
Drug	anethole	RELA NFKB1 MAPK3	1.38e-04	20	116	3	ctd:C006578
Drug	4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine	RELA SIRT1 NFKB1 MAPK3	1.43e-04	52	116	4	ctd:C108123
Drug	CP 205	SIRT1 MAPK3	1.53e-04	4	116	2	CID000174812
Drug	4,4,',4'',4'''-(carbonylbis(imino-5,1,3-benzenetriylbis(carbonylimino)))tetrakis(benzene-1,3-disulfonate)	GNAS MAPK3	1.53e-04	4	116	2	ctd:C110258
Drug	acenaphthenequinone	RELA NFKB1	1.53e-04	4	116	2	ctd:C023722
Drug	Mn(III) 5,10,15,20-tetrakis(N-methylpyridinium-2-yl)porphyrin	RELA NFKB1 MAPK3	1.60e-04	21	116	3	ctd:C502230
Drug	punarnavine	RELA NFKB1 MAPK3	1.60e-04	21	116	3	ctd:C526689
Disease	cerebral palsy (implicated_via_orthology)	AGAP7P AGAP4 AGAP6	6.96e-06	10	116	3	DOID:1969 (implicated_via_orthology)
Disease	Schizophrenia	DGCR2 NTNG1 RELA BCL11A PLEKHA6 SHANK3 SIRT1 PTPRZ1 B3GNT2 EIF5 GNAS MAPK3 CSMD1 IL2RA	9.99e-06	883	116	14	C0036341
Disease	behavioural disinhibition measurement	PALD1 RELA CACNA1I CSMD1 DNAH9	1.19e-05	75	116	5	EFO_0006946
Disease	X-14473 measurement	CYP2C19 CYP2C18	1.53e-05	2	116	2	EFO_0021370
Disease	cyclo(leu-pro) measurement	CYP2C19 CYP2C18	4.58e-05	3	116	2	EFO_0800676
Disease	squamous cell carcinoma (implicated_via_orthology)	ING5 ING4	4.58e-05	3	116	2	DOID:1749 (implicated_via_orthology)
Disease	X-21258 measurement	CYP2C19 CYP2C18	4.58e-05	3	116	2	EFO_0800802
Disease	platelet reactivity measurement, response to clopidogrel	CYP2C19 CYP2C18 PLCE1	9.90e-05	23	116	3	EFO_0004985, GO_1903493
Disease	Streptococcal pneumonia	SIRT1 MAPK3	2.27e-04	6	116	2	C0155862
Disease	fatty liver disease (implicated_via_orthology)	RELA SIRT1 NFKB1	2.46e-04	31	116	3	DOID:9452 (implicated_via_orthology)
Disease	neurodegenerative disease (implicated_via_orthology)	FAT4 BCL11A LATS2 NFKB1 HTT	2.77e-04	145	116	5	DOID:1289 (implicated_via_orthology)
Disease	Malignant neoplasm of breast	SYNE1 LRRC37A2 RELA BCL11A SIRT1 CCNH SLC8A3 LRRC37A EIF5 KAT6B DNAH9 GOLGB1 GAB1	3.15e-04	1074	116	13	C0006142
Disease	melanoma (implicated_via_orthology)	ING5 ING4	4.22e-04	8	116	2	DOID:1909 (implicated_via_orthology)
Disease	memory impairment	FAT4 SHANK3	4.22e-04	8	116	2	EFO_0001072
Disease	Todd Paralysis	ATP7A SIRT1	5.42e-04	9	116	2	C0234544
Disease	Paralysed	ATP7A SIRT1	5.42e-04	9	116	2	C0522224
Disease	plasma clozapine-to-N-desmethylclozapine ratio measurement	CYP2C19 CYP2C18	5.42e-04	9	116	2	EFO_0600040
Disease	Semantic-Pragmatic Disorder	BCL11A SHANK3	8.23e-04	11	116	2	C0454655
Disease	gastric adenocarcinoma (is_implicated_in)	UBR5 PLCE1	8.23e-04	11	116	2	DOID:3717 (is_implicated_in)
Disease	Auditory Processing Disorder, Central	BCL11A SHANK3	8.23e-04	11	116	2	C0751257
Disease	Language Delay	BCL11A SHANK3	8.23e-04	11	116	2	C0023012
Disease	Language Development Disorders	BCL11A SHANK3	8.23e-04	11	116	2	C0023014
Disease	Speech Delay	BCL11A SHANK3	8.23e-04	11	116	2	C0241210
Disease	Kidney Failure, Chronic	CYP2C19 RELA NFKB1	9.00e-04	48	116	3	C0022661
Disease	squamous cell carcinoma, multiple keratinocyte carcinoma susceptibility measurement, basal cell carcinoma	PALD1 CSMD1	1.16e-03	13	116	2	EFO_0000707, EFO_0004193, EFO_0007932
Disease	intelligence, self reported educational attainment	FOXO6 BCL11A HABP4 CACNA1I	1.19e-03	117	116	4	EFO_0004337, EFO_0004784
Disease	electrocardiography	MYCBP2 AXL PLEKHA6 ZNF592 ZNF358 KCNN2 KAT6B PLCE1	1.20e-03	530	116	8	EFO_0004327
Disease	household income	BCL11A KMT2E HABP4 RNF123 CACNA1I HTT	1.31e-03	304	116	6	EFO_0009695
Disease	dystonia (is_implicated_in)	TSPOAP1 KCNN2	1.35e-03	14	116	2	DOID:543 (is_implicated_in)
Disease	Pneumoconiosis	PTPRZ1 TMPRSS3	1.35e-03	14	116	2	C0032273
Disease	Bagassosis	PTPRZ1 TMPRSS3	1.35e-03	14	116	2	C0004681
Disease	mean corpuscular hemoglobin concentration	BMP2K AXL LRRC37A2 GON4L UBR5 NFKB1 B3GNT2 KCNK5 SMG9 CACNA1I AGAP7P GOLGB1	1.38e-03	1105	116	12	EFO_0004528
Disease	Brain Ischemia	RELA NFKB1 MAPK3	1.72e-03	60	116	3	C0007786
Disease	Cerebral Ischemia	RELA NFKB1 MAPK3	1.72e-03	60	116	3	C0917798
Disease	sickle cell anemia (is_implicated_in)	CYP2C19 BCL11A	1.77e-03	16	116	2	DOID:10923 (is_implicated_in)
Disease	lymphocyte count	PALD1 CYP2C19 SLC38A9 PCDHGA4 GATA2 PLEKHA6 HABP4 NFKB1 OSBPL7 SMG9 ARRDC2 IL2RA HTT PLCE1	1.84e-03	1464	116	14	EFO_0004587
Disease	Intellectual Disability	SYNE1 GON4L BCL11A KMT2E SHANK3 GNAS HTT	1.98e-03	447	116	7	C3714756
Disease	phosphatidylcholine 40:6 measurement	CSMD1 DNAH9	2.00e-03	17	116	2	EFO_0010389
Disease	carcinoma (implicated_via_orthology)	FAT4 SALL3 LATS2	2.07e-03	64	116	3	DOID:305 (implicated_via_orthology)
Disease	blood urea nitrogen measurement	GON4L PLEKHA6 SIRT1 LARP4B GNAS GAB1 PLCE1	2.10e-03	452	116	7	EFO_0004741
Disease	migraine disorder, systolic blood pressure	KCNK5 PLCE1	2.25e-03	18	116	2	EFO_0006335, MONDO_0005277
Disease	Hypertrophy	SIRT1 MAPK3	2.25e-03	18	116	2	C0020564
Disease	Malignant neoplasm of liver	WSCD1 HEBP2 SLC38A9 CCNH	2.43e-03	142	116	4	C0345904
Disease	Liver neoplasms	WSCD1 HEBP2 SLC38A9 CCNH	2.43e-03	142	116	4	C0023903
Disease	opioid dependence	FAT4 SRCIN1 CTDP1 CSMD1 SPINDOC	2.49e-03	237	116	5	EFO_0005611
Disease	schizophrenia, intelligence, self reported educational attainment	FOXO6 BCL11A KMT2E SHANK3 KCNN2 CACNA1I	2.51e-03	346	116	6	EFO_0004337, EFO_0004784, MONDO_0005090
Disease	response to methotrexate, juvenile idiopathic arthritis	CACNA1I CSMD1	2.51e-03	19	116	2	EFO_0002609, GO_0031427
Disease	breast cancer (is_implicated_in)	CYP2C19 UBR5 NFKB1 KAT6B	2.96e-03	150	116	4	DOID:1612 (is_implicated_in)
Disease	epilepsy (biomarker_via_orthology)	RELA SIRT1	3.06e-03	21	116	2	DOID:1826 (biomarker_via_orthology)
Disease	fetal hemoglobin measurement	BCL11A KCNN2	3.06e-03	21	116	2	EFO_0004576
Disease	Colonic Neoplasms	ATP7A RELA CCNH NFKB1	3.10e-03	152	116	4	C0009375
Disease	serum gamma-glutamyl transferase measurement	WSCD1 AXL HDX LMTK2 NTNG1 GON4L EIF5 KCNN2 CSMD1 PLCE1	3.29e-03	914	116	10	EFO_0004532
Disease	parental longevity	HDX BCL11A DHX15 CCSER2 KCNK5 CSMD1 HTT	3.44e-03	494	116	7	EFO_0007796
Disease	Parkinson's disease (implicated_via_orthology)	FOXO6 BMP2K SIRT1 KCNN2	3.48e-03	157	116	4	DOID:14330 (implicated_via_orthology)
Disease	Manic	NTNG1 SHANK3 ZNF592	3.63e-03	78	116	3	C0338831
Disease	Malignant tumor of colon	ATP7A RELA CCNH NFKB1	3.64e-03	159	116	4	C0007102
Disease	Huntington's disease (is_implicated_in)	SIRT1 HTT	3.67e-03	23	116	2	DOID:12858 (is_implicated_in)
Disease	tonsillectomy risk measurement	ZNF407 NFKB1 MDC1 MAPK3 IL2RA	3.71e-03	260	116	5	EFO_0007924

Protein segments in the cluster

Peptide	Gene	Start	Entry
EMPEALEFNPSANPE	AGAP4	71	Q96P64
PQPQMFGEELPDAQD	CTDP1	811	Q9Y5B0
NLELEDTDPMVNPPD	ATG13	401	O75143
LPNDPVFLEPHEEMT	CCNH	41	P51946
PPAVPQAEMLTEDDD	CSMD1	2261	Q96PZ7
ELPDTAENLPAMYPS	CCDC7	976	Q96M83
QDINDNPPVFPTDML	FAT4	1731	Q6V0I7
PLQAIPEMDFESSPA	ARHGEF33	571	A8MVX0
PEMDFESSPAEPLGN	ARHGEF33	576	A8MVX0
SFAMEAERPEHPLQP	ARHGEF33	661	A8MVX0
DPNMLLTPQEEDDPE	DMXL2	2016	Q8TDJ6
DLVHFDFMDPPAPET	DHX15	521	O43143
FMLEPDPEHRPDIFQ	BMP2K	296	Q9NSY1
MPEDLALESNPSDHP	CCNYL1	71	Q8N7R7
LPQDPDMSLEGPFFA	ARRDC2	361	Q8TBH0
EMPEALEFNPSANPE	AGAP6	71	Q5VW22
IDDMGFDAVIHNPDP	ATP7A	66	Q04656
QAPIYDEPPMDVQFE	ARHGAP39	321	Q9C0H5
MSPNPDAGEEELPFR	TSPOAP1	1641	O95153
PMPDFCAPREEDFDQ	PALD1	626	Q9ULE6
LNEPFDNSDEERPMP	KAT6B	1156	Q8WYB5
SFPAPKENPDMEEFR	PAPOLB	421	Q9NRJ5
MHFILDPEDPGAPQA	PCDHGA4	1	Q9Y5G9
QDPVPEQDFEMSPSS	KANSL1L	451	A0AUZ9
EEEPSSMQQEAPALP	LRRC37A3	251	O60309
PPELEEMDFNHASLE	HDX	656	Q7Z353
DEPTQAFMLTPPQEL	MDC1	716	Q14676
EPVPPEMNEQAFEAI	KIF15	701	Q9NS87
EEEPSSMQQEAPALP	LRRC37A2	251	A6NM11
EEEPSSMQQEAPALP	LRRC37A	251	A6NMS7
PMDTSNFDPVDEESP	LATS2	996	Q9NRM7
EMDSEAQPLQPPASV	KCNN2	26	Q9H2S1
EELDENYVPMNPNSP	GAB1	441	Q13480
MAEPLQPDPGAAEDA	HEBP2	1	Q9Y5Z4
AALPDPQESDPADMN	LARP4B	111	Q92615
EFDLPPAAMPNTENV	BCL11A	641	Q9H165
EMPEDIPLEPNPSDH	CCNYL2	71	Q5T2Q4
MQDVAPNPDDPEDFP	HABP4	396	Q5JVS0
QVPVIEFQDMPSFPA	PNMA6E	96	A0A0J9YXQ4
PEDSSPAPEVFMNQL	KCNK5	381	O95279
EMLHLPNPFDENPEL	PEAK1	1601	Q9H792
IPDVMPPQALFHDDD	KAT14	356	Q9H8E8
SDEMDFNFDSALPPP	FOXO6	461	A8MYZ6
QEDPDIPCMDAGLPF	MPP4	256	Q96JB8
DLPEKFDGNPDMLAP	PEG10	81	Q86TG7
PSFSELMEDPDPENP	KMT2E	1316	Q8IZD2
DYPPALLTTDMDNPE	LMTK2	566	Q8IWU2
PTDEPVAEEPFTFAM	MAPK3	336	P27361
VDMPTDNPELDLFPE	PTPRZ1	406	P23471
FANRPDPNTPMEETV	KCNAB2	156	Q13303
GPASPQADDQDMVEP	OR5H1	261	A6NKK0
HENGPPQDMFDSPKE	CCSER2	441	Q9H7U1
HNYMEPAQLLPPDEV	GATA2	31	P23769
NEINPPPHTMEEEED	EIF5	186	P55010
PQFLDDFFPPQDIMN	HTT	2981	P42858
HDNKEFPNPEMFDPR	CYP2C19	396	P33261
FPNPEMFDPRHFLDE	CYP2C19	401	P33261
EDMPLHPSQENSFAP	DBF4B	471	Q8NFT6
MATRNPPPQDYESDD	FUNDC1	1	Q8IVP5
PDPENFLCEMEEIPF	CACNA1I	1916	Q9P0X4
NFPNPNPFVEDDMDK	EIF3D	336	O15371
AELQAPDITPDMYDP	GON4L	511	Q3T8J9
ILSVMNVPDFDFPPE	GNAS	131	P63092
EMPEALEFNPSANPE	AGAP7P	71	Q5VUJ5
DESMPDPLPEFTEDQ	COL5A2	1241	P05997
PPDPIFASAMSENDN	DGCR2	216	P98153
DDPPEIPHATFKAMA	IL2RA	26	P01589
VHPSDVLDMPVDPNE	ING5	171	Q8WYH8
MEQLSDDPEGAFVPP	KNDC1	96	Q76NI1
HNDKEFPNPEMFDPG	CYP2C18	396	P33260
MAPFPEEVDVFTAPH	FBXL5	1	Q9UKA1
VPQFEFDPEMPLQAC	DNAH9	2436	Q9NYC9
IPNTPLPEGFQDAMD	SALL3	766	Q9BXA9
VDHERDPGPMNIQFE	SLC38A9	16	Q8NBW4
FPRDVSPPQEMSQED	MAP3K19	86	Q56UN5
MPPLPDHFSENAADF	MAP3K19	1286	Q56UN5
VHPSDVLDMPVDPNE	ING4	181	Q9UNL4
MDFQERDPPFLPESA	OSBPL7	1	Q9BZF2
PDGEHPFPEPMDTQE	IER2	86	Q9BTL4
TPELAHPPELMFDFE	NTNG1	96	Q9Y2I2
EDLALFPEPQPVENM	SEMA4F	476	O95754
PVPPDQLEDMAERFH	SYNE1	476	Q8NF91
ETDFSDDPMLPSPDQ	PLCE1	1516	Q9P212
TAMDDADPPGPENLF	HID1	311	Q8IV36
VPFMDSEAESENPPR	SMG9	431	Q9H0W8
QPNEFIMPDNAVPGD	SEPHS1	181	P49903
DFPDLPDPQAMFDIE	SIRT1	286	Q96EB6
DPDANPDAARMPAEI	SPINDOC	161	Q9BUA3
PDASPNVFEEPESNM	MYCBP2	3436	O75592
QLASDDEEPGPAFPM	RNF216	246	Q9NWF9
DEEPGPAFPMQESQE	RNF216	251	Q9NWF9
RVPLAHPEDMDPSDN	ARHGAP5	1076	Q13017
NLDEIPDGEMPQVDH	SEC23IP	431	Q9Y6Y8
EEPFVLPPAGEMEQD	NOP2	216	P46087
LPPAGEMEQDAQAPD	NOP2	221	P46087
KMALPAEPDPDFDPN	SPTBN5	851	Q9NRC6
PPEDNHPDLSDMLKF	B3GNT2	186	Q9NY97
ENLDEPFPEMLGEEP	ANGEL1	121	Q9UNK9
PDFPSINMDPAGLDD	RETREG3	331	Q86VR2
MGENDPPAVEAPFSF	TMPRSS3	1	P57727
LDFPPARPNEEMLSS	TIGD2	291	Q4W5G0
DIPNHNMVSEVPPER	PLEKHA6	16	Q9Y2H5
DFQMKQIDAPGDPFP	TSR1	296	Q2NL82
ETDFNKSVDFEMPPP	SRCIN1	851	Q9C0H9
ELAPAPMQSAAVAEP	SHANK3	1236	Q9BYB0
APPEDHPDEEMGFTI	PSPC1	51	Q8WXF1
LDEDEEPAPAMAQRP	RNF123	641	Q5XPI4
MPGDEVPVEEHFPEA	ZNF592	421	Q92610
HETETFPAMKDNLPP	SPAG1	116	Q07617
FDFQVGDEPPILPDM	TMED3	116	Q9Y3Q3
PPAQEPDEILYVNMD	AXL	811	P30530
MEPSGSEQLFEDPDP	TMCC1	1	O94876
VPSFMQPDDLEPGSE	WDR6	721	Q9NNW5
VAADPEAPEIQMFPQ	ZNF407	2031	Q9C0G0
EAPEIQMFPQAQESP	ZNF407	2036	Q9C0G0
HDPEPFTPEMKDLIN	WSCD1	536	Q658N2
HPPETCPFFEEMEAL	ZSCAN29	316	Q8IWY8
MDLEATPQDPNSAAP	ZSCAN29	386	Q8IWY8
MDELFPLIFPAEPAQ	RELA	1	Q04206
AKDEEPESMDFPAQP	KIAA0586	1166	Q9BVV6
DSDMPDHDLEPPRFA	UBR5	1311	O95071
EPQDPDPMSSSFDLD	ZNF358	81	Q9NW07
PDNSEIPENPAMEGF	UNC79	1556	Q9P2D8
DFPLMPNEESSLPAV	GOLGB1	621	Q14789
PAPEEQDLSMADFPP	KIAA1522	716	Q9P206
QDLSMADFPPPEEAF	KIAA1522	721	Q9P206
EEQPEEGMPPAIFNS	SLC8A3	491	P57103
FNPEVFQPQMALPTD	NFKB1	26	P19838