Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyCellularComponentAIM2 inflammasome complex

CASP1 CARD16

6.23e-054682GO:0097169
GeneOntologyCellularComponentIPAF inflammasome complex

CASP1 CARD16

6.23e-054682GO:0072557
GeneOntologyCellularComponentphagophore assembly site

ATG7 PIK3C3 WIPI2

2.77e-0439683GO:0000407
GeneOntologyCellularComponentprotease inhibitor complex

CASP1 CARD16

2.88e-048682GO:0097179
GeneOntologyCellularComponentNLRP3 inflammasome complex

CASP1 CARD16

2.88e-048682GO:0072559
GeneOntologyCellularComponentpeptidase inhibitor complex

CASP1 CARD16

5.63e-0411682GO:1904090
GeneOntologyCellularComponentPML body

GCNA ZNF451 KAT6A ZMYM2

7.38e-04125684GO:0016605
Domain-

KLHL2 KLHL36 KLHL21

1.27e-04276832.130.10.80
DomainGal_Oxidase_b-propeller

KLHL2 KLHL36 KLHL21

2.55e-0434683IPR015916
DomainEGF_1

NELL2 EYS FN1 DLL4 UMODL1 NAGPA

3.29e-04255686PS00022
DomainEGF-like_CS

NELL2 EYS FN1 DLL4 UMODL1 NAGPA

3.73e-04261686IPR013032
DomainASX_HYDROXYL

NELL2 EYS DLL4 UMODL1

4.85e-04100684PS00010
DomainBTB-kelch_protein

KLHL2 KLHL36 KLHL21

5.13e-0443683IPR017096
DomainEGF-type_Asp/Asn_hydroxyl_site

NELL2 EYS DLL4 UMODL1

6.04e-04106684IPR000152
DomainEGF_CA

NELL2 EYS DLL4 UMODL1

1.02e-03122684SM00179
DomainEGF-like_Ca-bd_dom

NELL2 EYS DLL4 UMODL1

1.09e-03124684IPR001881
DomainKelch

KLHL2 KLHL36 KLHL21

1.23e-0358683SM00612
Domain-

ZYG11A TERB1 APC TAF6 TNPO3

1.29e-032226851.25.10.10
DomainGal_Oxase/kelch_b-propeller

KLHL2 KLHL36 KLHL21

1.30e-0359683IPR011043
DomainBACK

KLHL2 KLHL36 KLHL21

1.36e-0360683SM00875
DomainEGF_extracell

NELL2 DLL4 NAGPA

1.36e-0360683IPR013111
DomainEGF_2

NELL2 DLL4 NAGPA

1.36e-0360683PF07974
DomainBACK

KLHL2 KLHL36 KLHL21

1.43e-0361683PF07707
DomainBACK

KLHL2 KLHL36 KLHL21

1.43e-0361683IPR011705
DomainARM-type_fold

ZYG11A PIK3C3 TERB1 APC TAF6 TNPO3

1.45e-03339686IPR016024
DomainCARD

CASP1 CARD16

1.52e-0316682SM00114
DomainEGF_3

NELL2 EYS DLL4 UMODL1 NAGPA

1.65e-03235685PS50026
DomainEGF

NELL2 EYS DLL4 UMODL1 NAGPA

1.65e-03235685SM00181
DomainKelch_1

KLHL2 KLHL36 KLHL21

2.12e-0370683PF01344
DomainKelch_1

KLHL2 KLHL36 KLHL21

2.12e-0370683IPR006652
DomainEGF-like_dom

NELL2 EYS DLL4 UMODL1 NAGPA

2.13e-03249685IPR000742
DomainVWC_out

NELL2 MUC5B

2.15e-0319682SM00215
DomainGrowth_fac_rcpt_

NELL2 EYS DLL4 UMODL1

2.52e-03156684IPR009030
DomainEGF_2

NELL2 EYS DLL4 UMODL1 NAGPA

2.79e-03265685PS01186
DomainARM-like

ZYG11A TERB1 APC TAF6 TNPO3

3.02e-03270685IPR011989
DomainHR1_rho-bd

RTKN2 TBC1D4

3.71e-0325682IPR011072
DomainBTB

KLHL2 KLHL36 KLHL21 KCNB2

4.21e-03180684SM00225
DomainPH_dom-like

RTKN2 TBC1D4 RASA3 SBF2 RABGAP1 ARHGEF15

4.52e-03426686IPR011993
DomainBTB/POZ_dom

KLHL2 KLHL36 KLHL21 KCNB2

4.63e-03185684IPR000210
DomainPID

TBC1D4 RABGAP1

4.64e-0328682PF00640
DomainCARD

CASP1 CARD16

4.64e-0328682PF00619
DomainVWC

NELL2 MUC5B

4.64e-0328682PF00093
DomainSKP1/BTB/POZ

KLHL2 KLHL36 KLHL21 KCNB2

5.00e-03189684IPR011333
DomainEGF_Ca-bd_CS

NELL2 EYS UMODL1

5.33e-0397683IPR018097
DomainEGF_CA

NELL2 EYS UMODL1

5.64e-0399683PS01187
DomainCARD

CASP1 CARD16

5.67e-0331682IPR001315
DomainPID

TBC1D4 RABGAP1

6.04e-0332682PS01179
DomainCARD

CASP1 CARD16

6.41e-0333682PS50209
Pubmed

HMGB1 promotes ductular reaction and tumorigenesis in autophagy-deficient livers.

ATG7 PIK3C3 CASP1

5.95e-07968329558368
Pubmed

Intestinal inhibition of Atg7 prevents tumour initiation through a microbiome-influenced immune response and suppresses tumour growth.

ATG7 APC

3.77e-06268226214133
Pubmed

Autophagy in the intestinal epithelium is not involved in the pathogenesis of intestinal tumors.

ATG7 APC

3.77e-06268222546555
Pubmed

Delta-like 4/Notch signaling promotes Apc Min/+ tumor initiation through angiogenic and non-angiogenic related mechanisms.

DLL4 APC

3.77e-06268228086833
Pubmed

LncRNA ADAMTS9-AS2 regulates periodontal ligament cell migration under mechanical compression via ADAMTS9/fibronectin.

FN1 ADAMTS9

1.13e-05368237957805
Pubmed

Miro-dependent mitochondrial pool of CENP-F and its farnesylated C-terminal domain are dispensable for normal development in mice.

CENPF RHOT1

1.13e-05368230856164
Pubmed

Mitotic redistribution of the mitochondrial network by Miro and Cenp-F.

CENPF RHOT1

1.13e-05368226259702
Pubmed

MUC5B mucin production is upregulated by fibronectin and laminin in human lung epithelial cells via the integrin and ERK dependent pathway.

FN1 MUC5B

1.13e-05368226057585
Pubmed

APC binds the Miro/Milton motor complex to stimulate transport of mitochondria to the plasma membrane.

APC RHOT1

1.13e-05368226658612
Pubmed

Deletion of PIK3C3/Vps34 in sensory neurons causes rapid neurodegeneration by disrupting the endosomal but not the autophagic pathway.

ATG7 PIK3C3

1.13e-05368220439739
Pubmed

Cop, a caspase recruitment domain-containing protein and inhibitor of caspase-1 activation processing.

CASP1 CARD16

2.25e-05468211432859
Pubmed

Correction of age-associated defects in dendritic cells enables CD4+ T cells to eradicate tumors.

CASP1 CCR7

2.25e-05468238870946
Pubmed

Gut microbial metabolism drives transformation of MSH2-deficient colon epithelial cells.

CASP1 APC

2.25e-05468225036629
Pubmed

ERK activation drives intestinal tumorigenesis in Apc(min/+) mice.

CASP1 APC

2.25e-05468220473309
Pubmed

Mutations of candidate tumor suppressor genes at chromosome 3p in intrahepatic cholangiocarcinoma.

ATG7 CACNA2D3

3.75e-05568229122566
Pubmed

Regulation of IL-1beta generation by Pseudo-ICE and ICEBERG, two dominant negative caspase recruitment domain proteins.

CASP1 CARD16

3.75e-05568211536016
Pubmed

Keratin 8-deletion induced colitis predisposes to murine colorectal cancer enforced by the inflammasome and IL-22 pathway.

CASP1 APC

3.75e-05568227234655
Pubmed

Mitophagy deficiency increases NLRP3 to induce brown fat dysfunction in mice.

ATG7 CASP1

3.75e-05568232400277
Pubmed

Inflammasomes within Hyperactive Murine Dendritic Cells Stimulate Long-Lived T Cell-Mediated Anti-tumor Immunity.

CASP1 CCR7

5.62e-05668233207188
Pubmed

Alterations in the microbiota drive interleukin-17C production from intestinal epithelial cells to promote tumorigenesis.

CASP1 APC

5.62e-05668224412611
Pubmed

PtdIns5P regulation through evolution: roles in membrane trafficking?

PIK3C3 SBF2

5.62e-05668218774718
Pubmed

INCA, a novel human caspase recruitment domain protein that inhibits interleukin-1beta generation.

CASP1 CARD16

5.62e-05668215383541
Pubmed

LncGata6 maintains stemness of intestinal stem cells and promotes intestinal tumorigenesis.

BPTF APC

5.62e-05668230224759
Pubmed

Control of cardiac jelly dynamics by NOTCH1 and NRG1 defines the building plan for trabeculation.

FN1 DLL4 ADAMTS9

5.74e-053868329743679
Pubmed

Update on the Kelch-like (KLHL) gene family.

KLHL2 KLHL36 KLHL21

7.23e-054168323676014
Pubmed

PtdIns(3)P-bound UVRAG coordinates Golgi-ER retrograde and Atg9 transport by differential interactions with the ER tether and the beclin 1 complex.

ATG7 PIK3C3

7.86e-05768224056303
Pubmed

Cross-species regulatory network analysis identifies a synergistic interaction between FOXM1 and CENPF that drives prostate cancer malignancy.

CENPF APC

1.05e-04868224823640
Pubmed

Protective role of Cop in Rip2/caspase-1/caspase-4-mediated HeLa cell death.

CASP1 CARD16

1.34e-04968216920334
Pubmed

PDPK1 regulates autophagosome biogenesis by binding to PIK3C3.

PIK3C3 WIPI2

1.34e-04968232876514
Pubmed

The N-Degron Pathway Mediates ER-phagy.

PIK3C3 WIPI2

1.34e-04968231375263
Pubmed

Endothelial deletion of murine Jag1 leads to valve calcification and congenital heart defects associated with Alagille syndrome.

DLL4 ADAMTS9

1.34e-04968223095891
Pubmed

PI(5)P regulates autophagosome biogenesis.

PIK3C3 WIPI2

1.68e-041068225578879
Pubmed

LC3-Associated Endocytosis Facilitates β-Amyloid Clearance and Mitigates Neurodegeneration in Murine Alzheimer's Disease.

ATG7 PIK3C3

1.68e-041068231257024
Pubmed

Select autophagy genes maintain quiescence of tissue-resident macrophages and increase susceptibility to Listeria monocytogenes.

ATG7 CASP1

1.68e-041068231959973
Pubmed

CARD-8 protein, a new CARD family member that regulates caspase-1 activation and apoptosis.

CASP1 CARD16

1.68e-041068211821383
Pubmed

Targeting of protein ubiquitination by BTB-Cullin 3-Roc1 ubiquitin ligases.

KLHL36 KLHL21

2.05e-041168214528312
Pubmed

Mst1 inhibits autophagy by promoting the interaction between Beclin1 and Bcl-2.

ATG7 PIK3C3

2.05e-041168224141421
Pubmed

IL-22BP is regulated by the inflammasome and modulates tumorigenesis in the intestine.

CASP1 APC

2.05e-041168223075849
Pubmed

Global analysis of host-pathogen interactions that regulate early-stage HIV-1 replication.

DHX15 UMODL1 KAT6A TNPO3 GAREM1

2.36e-0428368518854154
Pubmed

A central chaperone-like role for 14-3-3 proteins in human cells.

FAM171A1 TBC1D4 PIK3C3 APC TMEM102 GEN1 TNPO3 PALLD

2.72e-0486168836931259
Pubmed

A phospho/methyl switch at histone H3 regulates TFIID association with mitotic chromosomes.

BPTF TAF6

2.90e-041368220953165
Pubmed

3D biomimetic platform reveals the first interactions of the embryo and the maternal blood vessels.

FN1 DLL4

2.90e-041368234741805
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

HEXA RASA3 KLHL36 KLHL21 SBF2 KAT6A BAHD1 TNPO3 GAREM1

2.93e-04110568935748872
Pubmed

A targeted mutation of Nkd1 impairs mouse spermatogenesis.

FN1 APC

3.38e-041468215546883
Pubmed

Host-Protozoan Interactions Protect from Mucosal Infections through Activation of the Inflammasome.

APC CCR7

3.38e-041468227716507
Pubmed

Impaired ADAMTS9 secretion: A potential mechanism for eye defects in Peters Plus Syndrome.

FN1 ADAMTS9

3.38e-041468227687499
Pubmed

Loss of Notch signalling induced by Dll4 causes arterial calibre reduction by increasing endothelial cell response to angiogenic stimuli.

FN1 DLL4

3.89e-041568219087347
Pubmed

Expression profiling of mouse subplate reveals a dynamic gene network and disease association with autism and schizophrenia.

FN1 CACNA2D3

3.89e-041568223401504
Pubmed

LC3-Associated Phagocytosis in Myeloid Cells Promotes Tumor Immune Tolerance.

ATG7 PIK3C3

3.89e-041568230245008
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

ADAMTS9 SBF2 SCAPER PALLD ARHGEF15 C2CD5

4.10e-0449368615368895
Pubmed

Hemodynamic Forces Sculpt Developing Heart Valves through a KLF2-WNT9B Paracrine Signaling Axis.

FN1 WNT9B

4.44e-041668229056552
Pubmed

Efficient transposition of the piggyBac (PB) transposon in mammalian cells and mice.

GEN1 CACNA2D3

4.44e-041668216096065
Pubmed

A ZFYVE21-Rubicon-RNF34 signaling complex promotes endosome-associated inflammasome activity in endothelial cells.

CASP1 CARD16

4.44e-041668237225719
Pubmed

A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

TBC1D4 CENPF APC ZMYM2 TAF6 PALLD

4.56e-0450368616964243
Pubmed

Temporal requirements for ISL1 in sympathetic neuron proliferation, differentiation, and diversification.

CENPF DLL4 KCNB2

4.71e-047768329445148
Pubmed

Chromatin boundaries require functional collaboration between the hSET1 and NURF complexes.

BPTF TAF6

5.03e-041768221653943
Pubmed

Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo.

ATG7 PIK3C3

5.03e-041768225327288
Pubmed

Overexpression of delta-like 4 induces arterialization and attenuates vessel formation in developing mouse embryos.

FN1 DLL4

5.03e-041768218559979
Pubmed

USF1 recruits histone modification complexes and is critical for maintenance of a chromatin barrier.

BPTF TAF6

5.65e-041868217846119
Pubmed

Genetically distinct subsets within ANCA-associated vasculitis.

WNT9B PCDH11X

5.65e-041868222808956
Pubmed

Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.

BPTF TBC1D4 TTLL3 ATG7 RASA3 PIK3C3 SBF2 KAT6A RABGAP1 TARS2

6.07e-041489681028611215
Pubmed

Spatial and temporal heterogeneity of mouse and human microglia at single-cell resolution.

FN1 APC

6.30e-041968230760929
Pubmed

A ubiquitin-based effector-to-inhibitor switch coordinates early brain, craniofacial, and skin development.

KLHL2 KLHL36 KLHL21

6.74e-048768337495603
Pubmed

BMP-Responsive Protease HtrA1 Is Differentially Expressed in Astrocytes and Regulates Astrocytic Development and Injury Response.

FN1 APC

7.00e-042068229483282
Pubmed

CBAP functions as a novel component in chemokine-induced ZAP70-mediated T-cell adhesion and migration.

CCR7 TMEM102

7.00e-042068223620790
Pubmed

The molecular anatomy of mammalian upper lip and primary palate fusion at single cell resolution.

ADAMTS9 WNT9B

7.00e-042068231118233
Pubmed

Interactomes of Glycogen Synthase Kinase-3 Isoforms.

TBC1D4 APC PALLD WIPI2

7.64e-0420968436779422
Pubmed

Immunomic analysis of human sarcoma.

TBC1D4 PALLD

7.72e-042168212601173
Pubmed

DLL4 promotes continuous adult intestinal lacteal regeneration and dietary fat transport.

FN1 DLL4

7.72e-042168226529256
Pubmed

Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer.

DHX15 BPTF ATG7 ZNF451 CASP1 RABGAP1 TAF6 MYO15A

7.99e-04101468832416067
Pubmed

The ER-Localized Transmembrane Protein EPG-3/VMP1 Regulates SERCA Activity to Control ER-Isolation Membrane Contacts for Autophagosome Formation.

PIK3C3 WIPI2

8.48e-042268228890335
Pubmed

Systematically defining selective autophagy receptor-specific cargo using autophagosome content profiling.

DHX15 HEXA BPTF NSUN5 TBC1D4 PIK3C3 APC TNPO3 PALLD

9.25e-04129768933545068
Pubmed

Secreted metalloproteases ADAMTS9 and ADAMTS20 have a non-canonical role in ciliary vesicle growth during ciliogenesis.

FN1 ADAMTS9

9.28e-042368230814516
Pubmed

Meiotic gatekeeper STRA8 suppresses autophagy by repressing Nr1d1 expression during spermatogenesis in mice.

ATG7 PIK3C3

9.28e-042368231059511
Pubmed

ADAMTS9-Mediated Extracellular Matrix Dynamics Regulates Umbilical Cord Vascular Smooth Muscle Differentiation and Rotation.

FN1 ADAMTS9

9.28e-042368226027930
Pubmed

Myocardial Angiopoietin-1 Controls Atrial Chamber Morphogenesis by Spatiotemporal Degradation of Cardiac Jelly.

DLL4 ADAMTS9

1.01e-032468229791855
Pubmed

Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.

TBC1D4 ZNF451 C2CD5

1.16e-031056839628581
Pubmed

Reconstruction of phrenic neuron identity in embryonic stem cell-derived motor neurons.

DLL4 PCDH11X

1.28e-032768224496616
Pubmed

Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.

TBC1D4 CENPF APC ZMYM2 RABGAP1

1.37e-0341868534709266
Pubmed

Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.

BPTF NELL2 KLHL21 KAT6A SCAPER TAF6 C2CD5 RHOT1

1.47e-03111668831753913
Pubmed

Interrogating translational efficiency and lineage-specific transcriptomes using ribosome affinity purification.

DLL4 ARHGEF15

1.48e-032968224003143
Pubmed

SLFN11 promotes CDT1 degradation by CUL4 in response to replicative DNA damage, while its absence leads to synthetic lethality with ATR/CHK1 inhibitors.

DHX15 BPTF CENPF APC

1.48e-0325068433536335
Pubmed

Overactive Wnt5a signaling disrupts hair follicle polarity during mouse skin development.

FN1 WNT9B

1.58e-033068236305473
Pubmed

Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization.

DHX15 TBC1D4 PIK3C3 TMEM102

1.59e-0325568415324660
Pubmed

Identification of proximal SUMO-dependent interactors using SUMO-ID.

DHX15 ZNF451 ZMYM2 TAF6 PALLD

1.79e-0344468534795231
Pubmed

Systematic analysis of human protein complexes identifies chromosome segregation proteins.

DHX15 KLHL2 RTKN2 DCAF10 CENPF ZNF451 APC ZMYM2

1.83e-03115568820360068
InteractionZNF726 interactions

ZNF430 DCAF10 TRIM39

7.91e-0612683int:ZNF726
Cytoband1p36.31

KLHL21 RNF207

1.94e-04146821p36.31
GeneFamilyKelch like|BTB domain containing

KLHL2 KLHL36 KLHL21

1.76e-0442473617
GeneFamilyCalcium voltage-gated channel subunits

CACNA1G CACNA2D3

2.07e-0326472253
GeneFamilyWD repeat domain containing|Caspase recruitment domain containing|Apoptosome

CASP1 CARD16

2.75e-0330472959
GeneFamilyAutophagy related

ATG7 WIPI2

3.32e-03334721022
GeneFamilyBasic leucine zipper proteins|BTB domain containing

KLHL2 KLHL36 KLHL21

5.09e-03134473861
CoexpressionDACOSTA_UV_RESPONSE_VIA_ERCC3_COMMON_DN

DHX15 FAM171A1 BPTF CENPF PIK3C3 KAT6A ZMYM2 RABGAP1 C2CD5

3.20e-06466689M13522
CoexpressionDACOSTA_UV_RESPONSE_VIA_ERCC3_DN

DHX15 FAM171A1 BPTF CENPF PIK3C3 ZNF451 KAT6A APC ZMYM2 RABGAP1 C2CD5

1.18e-058566811M4500
ToppCell10x5'-GI_small-bowel-Lymphocytic_T_CD4-Teffector/EM_CD4|GI_small-bowel / Manually curated celltypes from each tissue

NELL2 TBC1D4 RASA3 TTC9B FAM78B CCR7

1.45e-07156686e308328f560c5ee7e9f95ac5db162f2d821ca39c
ToppCellLPS-IL1RA-Myeloid-Monocytes,_Macrophages-Neutrophils|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

EYS CENPF KLHL21 CACNA1G CCR7

2.33e-06139685505bf5a483fc2ba69377db9850c3b26ab2f416d1
ToppCell3'_v3-GI_small-bowel-Lymphocytic_T_CD4-Tregs|GI_small-bowel / Manually curated celltypes from each tissue

RTKN2 TBC1D4 CASP1 CARD16 CCR7

3.98e-06155685d4ef25965a15eab7679478b9b661e1b4a92f1c59
ToppCellChildren_(3_yrs)-Endothelial-endothelial_cell_of_vein-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

FAM171A1 ADAMTS9 WNT9B TRIM39 ARHGEF15

5.73e-06167685d7fe24cdc4b55a9555ce9e20699f5036b88148e9
ToppCellsevere-CD8+_T_naive|severe / disease stage, cell group and cell class

ZNF430 NELL2 KLHL36 TRIM39 CCR7

8.24e-0618068594fe530367b170777f4051a4034cff06d80dbb83
ToppCell(1)_T_CD4_naive|World / Spleen cell shreds - cell class (v1) and cell subclass (v1)

RTKN2 NELL2 TBC1D4 RASA3 CCR7

1.02e-05188685b8f67ac2faadd5b848955e43ab5d6cf5e49b3681
ToppCell3'-Child09-12-SmallIntestine-Epithelial-epithelial_progenitor_cell-TA|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

FAM171A1 CASP1 ATP10B GSTO2 RNF182

1.24e-05196685055993612af03bff5ef73580a6402578da850df9
ToppCellLPS_anti-TNF-Epithelial_alveolar-AT_1-Differentiating_AT2|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

RTKN2 SCAPER PCDH11X RNF207 FAAH

1.27e-051976853d13a4f2e86422900ee2194e8a1fd1cf9750d5d3
ToppCell10x_3'_v2v3-Non-neoplastic-Myeloid-TAM-BDM-TAM-BDM_MHC-Z|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

HEXA FN1 CASP1 CARD16 CACNA2D3

1.34e-05199685639539d27e8ea1cc47630a69668e6cba02f8c9ca
ToppCellLPS_IL1RA_TNF-Endothelial-Endothelial-Artery|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

FAM171A1 FN1 DLL4 RABGAP1 ARHGEF15

1.37e-0520068577ae679c35d3b9e2b620f34129f3a8d47e922c65
ToppCellLPS_anti-TNF-Endothelial-Endothelial-Artery|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

FN1 DLL4 RABGAP1 PALLD ARHGEF15

1.37e-05200685b1ff8d61b567f85006d6d20093f9c803b6d34674
ToppCellPND28-Immune-Immune_Myeloid-DC-maDC|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

NSUN5 TBC1D4 CCR7 PALLD

8.84e-05153684b03375c54aa701817c0fc2c3fef32b870169e697
ToppCellPND28-Immune-Immune_Myeloid-DC-maDC-maDC_mature|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

NSUN5 TBC1D4 CCR7 PALLD

8.84e-0515368418bd770a18e642581a6df144d47184c1ac383713
ToppCellCV-Healthy-3|Healthy / Virus stimulation, Condition and Cluster

RTKN2 TBC1D4 KLHL21 FAAH

9.07e-0515468426bf81a86700db7e65c2384ffe94ed4253ea4047
ToppCell367C-Lymphocytic-CD4_T-cell-Treg_cell_2|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

RTKN2 TBC1D4 ZMYM2 CARD16

9.07e-05154684b16f3139ce50e70a6a2377b1da7d7877b4000ea1
ToppCell367C-Lymphocytic-CD4_T-cell-Treg_cell_2|367C / Donor, Lineage, Cell class and subclass (all cells)

RTKN2 TBC1D4 ZMYM2 CARD16

9.77e-05157684f1c6c313836352271033d23efd31b0f0a8a09e02
ToppCellsevere_influenza-CD4+_T_naive|World / disease group, cell group and cell class (v2)

NELL2 TBC1D4 CCR7 MYO15A

1.00e-041586848ab3d8a9b7a1daa890d76dde1d6182af40b70021
ToppCell10x5'-Lung-Lymphocytic_T_CD4-Tregs|Lung / Manually curated celltypes from each tissue

RTKN2 TBC1D4 CCR7 RNF207

1.00e-04158684f433bc189f000efa34e8e09ab32b3fa22bcf64c4
ToppCellInt-URO-Lymphocyte-T_NK-Treg|Int-URO / Disease, Lineage and Cell Type

RTKN2 TBC1D4 UMODL1 CCR7

1.00e-04158684457d64dceedb67bfff1303334cda1253a839b3d6
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22_with-steroid-Myeloid-Monocytic-Nonclassical_Monocyte-Mono_c5-CD16|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

FN1 FAM78B CHML FAAH

1.03e-04159684210ac7fa89514a84f38d9f42254e38fbc2bc5f42
ToppCellAdult-Endothelial-endothelial_cell_of_vein-D122|Adult / Lineage, Cell type, age group and donor

FAM171A1 UMODL1 WNT9B ARHGEF15

1.05e-041606840cfe130606af433b2aa90e0a20b6c44659dd6fd4
ToppCellCV-Healthy-3|CV / Virus stimulation, Condition and Cluster

RTKN2 TBC1D4 KLHL21 FAAH

1.08e-04161684fd4a79385ea967b9900dc76a3add813b894a3a28
ToppCell3'_v3-GI_small-bowel-Lymphocytic_T_CD4-Teffector/EM_CD4|GI_small-bowel / Manually curated celltypes from each tissue

NELL2 RASA3 CCR7 FAAH

1.18e-04165684ecaeb90a6bc27524ef6f2eefa72aec7315dbde3b
ToppCellFetal_29-31_weeks-Endothelial-endothelial_cell_of_vein-D088|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

FAM171A1 ADAMTS9 WNT9B ARHGEF15

1.21e-04166684f7926ee266dcbf10df375cd921f1db5a2fa604f8
ToppCellsystemic_lupus_erythematosus-flare-Hematopoietic-Progen-male|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

RTKN2 NELL2 UMODL1 CCR7

1.24e-04167684b89ebd4906f52b1fe6b6540ec9339284e7caddd2
ToppCelldroplet-Heart-nan-18m-Hematologic-coronary_vascular_endothelial_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FAM171A1 NSUN5 ADAMTS9 TARS2

1.27e-041686842201ae834b53cbdc085f8f02607fa5b5bd911268
ToppCell356C-Myeloid-Dendritic-cDC_activated|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

TBC1D4 FAM78B CCR7 RNF207

1.30e-0416968444d201361eb497222a4972a0e10bac1e05dcfd0a
ToppCell3'-Distal_airway-Immune_Myeloid-Myeloid_monocytic-classical_monocyte-Classical_monocytes-Classical_monocytes_L.1.2.0.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ZYG11A CASP1 CARD16 CACNA2D3

1.33e-041706843e52d40b0c36ab5b627a2dad025248901af8a320
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_2-Exc_L3-5_RORB_CMAHP|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

NELL2 TTC9B PCDH11X KCNB2

1.36e-041716849d5cabd71a901a00eb16c4d151189296f1b3bf6f
ToppCellAdult-Endothelial-endothelial_cell_of_bronchial_vessel|Adult / Lineage, Cell type, age group and donor

FAM171A1 DLL4 ADAMTS9 ARHGEF15

1.39e-04172684ad4ffdb3fc0c560a9cbaa2bc048476cbc43e8fd6
ToppCellMesenchymal_cells-Osteo-CAR|Mesenchymal_cells / Lineage and Cell class

ADAMTS9 FAM78B PALLD RNF182

1.45e-04174684430e3cd61bc2a471959faa40e817aa4dd7d82d28
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

FN1 DLL4 PCDH11X ARHGEF15

1.58e-041786845f779a66aa42d1d8e8af17b4a08d5dcc733efd4c
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_5|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

NELL2 TTC9B PCDH11X KCNB2

1.58e-04178684731e1e8eff2c4018c75dfc66632a316010a09a9a
ToppCellsevere-CD8+_T_naive|World / disease stage, cell group and cell class

ZNF430 KLHL36 TRIM39 CCR7

1.69e-0418168469eeeb7f326e230b07495d557f708fbe3312ac0a
ToppCell356C-Lymphocytic-CD4_T-cell-Treg_cell_2|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

RTKN2 TBC1D4 PKD1L1 C2CD5

1.76e-04183684f142b320023eef00b48d4820c46214c9794d37e7
ToppCell(1)_T_cells-(1)_T_regulatory|(1)_T_cells / Lung cell shreds - cell class (v4) and cell subclass (v4)

RTKN2 TBC1D4 FAM78B CARD16

1.80e-041846843cbf81757653652441843d85cb7ec1dcf25ca1b0
ToppCellPBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c01-LEF1|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)

NELL2 TBC1D4 RASA3 CCR7

1.80e-04184684bd786db4dc4edae6d5cfc0b69901983dea19f729
ToppCell356C-Lymphocytic-CD4_T-cell-Treg_cell_2|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)

RTKN2 PKD1L1 C2CD5 RHOT1

1.83e-04185684e06a784a297f357f3f8e761c24fa70722048ab42
ToppCelldroplet-Lung-18m-Hematologic-myeloid-classical_monocyte_proliferating-classical_monocyte_proliferating_l33-52|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

RTKN2 CENPF MUC5B TAF6

1.83e-0418568447c69500877b851c0c9744f5e1ef2ee0bff99168
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d03-09-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c02-GPR183|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)

NELL2 TBC1D4 RASA3 CCR7

1.83e-04185684847257d232b9993cad50c814fd4ffeef52385295
ToppCellnormal_Lung-T/NK_cells-Treg|T/NK_cells / Location, Cell class and cell subclass

RTKN2 TBC1D4 FAM78B CARD16

1.83e-04185684ea416362d3f06b4a0a7f08c2e5dbbc864f121555
ToppCellPBMC-Control-cDC_10|Control / Compartment, Disease Groups and Clusters

TBC1D4 FAM78B CCR7 RNF207

1.83e-041856844b5a7450fed912f340da16065c1e65d626dbe8d1
ToppCellMesenchymal_cells-Osteo-CAR|World / Lineage and Cell class

ADAMTS9 FAM78B PALLD RNF182

1.83e-0418568416f1588893d09c864e0cb4f837a1b972a1a57baa
ToppCelldroplet-Lung-nan-18m-Mesenchymal-pulmonary_interstitial_fibroblast|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PCDH11X CACNA1G PALLD CACNA2D3

1.87e-04186684b58db5abdd3e9f0214b198c3cbd09b0b3c321eab
ToppCelltumor_Lymph_Node_/_Brain-Fibroblasts-Undetermined|Fibroblasts / Location, Cell class and cell subclass

DCAF10 KLHL36 TARS2 WIPI2

1.87e-04186684403ac98f72a42721f84fbd7826f251a88ae534a2
ToppCelldroplet-Lung-nan-18m-Mesenchymal-Myofibroblast|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PCDH11X CACNA1G PALLD CACNA2D3

1.87e-04186684cd6502bbf9dce318fdbb4965d49df8951e5f795c
ToppCellAdult-Endothelial-endothelial_cell_of_artery|Adult / Lineage, Cell type, age group and donor

FAM171A1 DLL4 WNT9B PCDH11X

1.87e-041866842d1c4ea2e401db89971582ee54618a8b0c81b8ac
ToppCellChildren_(3_yrs)-Endothelial-endothelial_cell_of_vein|Children_(3_yrs) / Lineage, Cell type, age group and donor

FAM171A1 ADAMTS9 WNT9B ARHGEF15

1.91e-04187684e35716f8b482be3bf5ab79f087a9caf67a9d197a
ToppCellmetastatic_Brain-T/NK_cells-Treg|metastatic_Brain / Location, Cell class and cell subclass

RTKN2 TBC1D4 CASP1 CARD16

1.91e-041876841b88e1399809c50a0156096d9c82b1d9e58bb720
ToppCellLPS_only-Epithelial_alveolar-AT_1|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

RTKN2 RNF207 CACNA2D3 GAREM1

1.91e-04187684ff26a533d310126521efe1d05cf8b9d32e524550
ToppCelldroplet-Lung-18m-Mesenchymal-myofibroblast-myofibroblast_cell-pulmonary_interstitial_myofibroblast|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

PCDH11X CACNA1G PALLD CACNA2D3

1.91e-041876848bd635abdee5d5a12a3f7bf74eab4282e8e40741
ToppCelldroplet-Lung-18m-Mesenchymal-myofibroblast-myofibroblast_cell|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

PCDH11X CACNA1G PALLD CACNA2D3

1.91e-041876843cb8cd7f7a4306ff74d1f7f9964014008ec1c6a0
ToppCellVE-Treg-CD4_Treg|VE / Condition, Cell_class and T cell subcluster

RTKN2 TBC1D4 CASP1 CARD16

1.95e-04188684fa88ceb336e30de3585e62608527a0d44df74190
ToppCellVE-Treg|VE / Condition, Cell_class and T cell subcluster

RTKN2 TBC1D4 CASP1 CARD16

1.95e-04188684ef048517dfe2fc995d13eb1f08106a487354a4cc
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Afferent_/_Efferent_Arteriole_Endothelial_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

FN1 DLL4 PCDH11X ARHGEF15

2.03e-04190684bf9bc57a605c7e3979bc4f7260e6fb92c3eb8690
ToppCellILEUM-non-inflamed-(1)_T_cell-(1)_Tregs|(1)_T_cell / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

RTKN2 TBC1D4 CASP1 CARD16

2.03e-04190684f69a4733b5d1542ab4d0eb44856f2c5c34c18b9e
ToppCell367C-Lymphocytic-NK_cells-NK_cell_B1|NK_cells / Donor, Lineage, Cell class and subclass (all cells)

DHX15 PIK3C3 TAF6 BAHD1

2.03e-041906842434b8ad2976eab7d9147012c28454ab29670709
ToppCellCOVID-19-Heart-EC_3|Heart / Disease (COVID-19 only), tissue and cell type

KLHL2 ADAMTS9 WNT9B ARHGEF15

2.03e-0419068478e7c502b0450c0b37652b1896a2a752fd8a2111
ToppCellmetastatic_Lymph_Node-T/NK_cells-Treg|metastatic_Lymph_Node / Location, Cell class and cell subclass

RTKN2 TBC1D4 FAM78B CARD16

2.03e-041906840523f1039b39a45a23f2f4444e5b47ed581fc4bb
ToppCellRV-06._Ventricular_Cardiomyocyte_II|RV / Chamber and Cluster_Paper

TBC1D4 RNF207 PALLD CACNA2D3

2.03e-04190684fe8e78922c8ae928ef9a80bffd67868d5a87a091
ToppCell(3)_MNP-(3)_DC_activated|(3)_MNP / Lung cell shreds - cell class (v4) and cell subclass (v4)

NELL2 TBC1D4 CCR7 PALLD

2.07e-041916840353bf797c4ef237b9bb82460c173c7d03cb8883
ToppCellILEUM-non-inflamed-(1)_Tregs|non-inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

RTKN2 TBC1D4 CASP1 CARD16

2.07e-04191684e065d16a1f88c91dec576d248a318534ceab1cb2
ToppCell3'-GW_trimst-2-SmallIntestine-Neuronal-neurons_B-Branch_B1_(eMN)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

NELL2 TTC9B FAM78B RNF182

2.07e-0419168473b15ffa60d592c43aaa575f1b1479d49a66dfe8
ToppCellCV-Mild-5|CV / Virus stimulation, Condition and Cluster

RTKN2 NELL2 TBC1D4 CCR7

2.07e-04191684cf40d2b3daeb968b05b4dc2a0a9dc3eb9a0cccfa
ToppCellnormal_Lymph_Node-T/NK_cells-Treg|normal_Lymph_Node / Location, Cell class and cell subclass

RTKN2 TBC1D4 CASP1 CARD16

2.11e-04192684d2c2a98d331522a3ab7973bfaf4396ef4d684888
ToppCellLPS-antiTNF-Endothelial-Endothelial-Activated_Gen_Cap|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

FAM171A1 DLL4 ADAMTS9 ARHGEF15

2.11e-041926840aeb5351275c0a91151ea2d52b2cdde172da6731
ToppCellCOVID-19_Moderate-CD4+_T_activated|COVID-19_Moderate / disease group, cell group and cell class

RTKN2 NELL2 TBC1D4 CCR7

2.11e-041926847a81652406332afd03a9b3b529e9b5e6c0b54c28
ToppCellmetastatic_Brain-T/NK_cells-Treg|T/NK_cells / Location, Cell class and cell subclass

RTKN2 TBC1D4 CASP1 CARD16

2.11e-041926847c6f44716fc684b0297f266f04968e26fabdf6e3
ToppCellILEUM-inflamed-(1)_Tregs|inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

RTKN2 TBC1D4 CASP1 CARD16

2.11e-041926841fe3417dfd1cf1758fd82c9ac13dbd88bdf0b548
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

FN1 DLL4 PCDH11X ARHGEF15

2.11e-0419268456b021c297a21dff357531f21e2464f85186106d
ToppCellCOVID-19_Moderate-CD4+_T_activated|World / disease group, cell group and cell class

RTKN2 NELL2 TBC1D4 CCR7

2.16e-04193684c2a2a2c14a7085690262db5c2a70e38db67dee18
ToppCelltumor_Lung-T/NK_cells-Treg|tumor_Lung / Location, Cell class and cell subclass

RTKN2 TBC1D4 CASP1 CARD16

2.16e-04193684675645fb2e8e75fedba2ab51f67200961bfd2436
ToppCellTCGA-Prostate-Primary_Tumor-Prostate_Adenocarcinoma-Acinar_Adenocarcinoma-6|TCGA-Prostate / Sample_Type by Project: Shred V9

BPTF DCAF10 SBF2 CHML

2.16e-04193684abd71b2cf667ef2b1c4d88acd0c1dd19a12ff659
ToppCellControl-Endothelial-Endothelial|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

FAM171A1 SBF2 KAT6A ARHGEF15

2.16e-04193684aff0649c73c634bc6ff0dc7759b4693a9236bf05
ToppCellControl-Endothelial|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

FAM171A1 SBF2 KAT6A ARHGEF15

2.16e-04193684c5f9fe03e64c211d4bcd4959e5b32f14841e336a
ToppCellCV-Mild-5|Mild / Virus stimulation, Condition and Cluster

RTKN2 NELL2 TBC1D4 CCR7

2.16e-041936842053f0f8083b3174e1b6f76d2d7089f59982565d
ToppCelltumor_Lung-Endothelial_cells-Stalk-like_ECs|tumor_Lung / Location, Cell class and cell subclass

FAM171A1 DLL4 ADAMTS9 ARHGEF15

2.16e-0419368421fec35587ffb5c0157e54a821ce3ffd3e24e536
ToppCell10x5'-GI_small-bowel-Lymphocytic_T_CD4-Tnaive/CM_CD4|GI_small-bowel / Manually curated celltypes from each tissue

NELL2 TBC1D4 RASA3 CCR7

2.16e-04193684772e0370bda4bffed7798b8714e32c9e2a1d9b67
ToppCellnormal_Lymph_Node-T/NK_cells-Treg|T/NK_cells / Location, Cell class and cell subclass

RTKN2 TBC1D4 CASP1 CARD16

2.16e-0419368451fd629e91c85881c3231486d6d2fb2c65fcd77b
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

ZNF430 RTKN2 ADAMTS9 GAREM1

2.20e-0419468446070fbb0ee0eb9e1801c43b73a15707471056dc
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

ZNF430 RTKN2 ADAMTS9 GAREM1

2.20e-04194684abacb6a8d7a9003f2f6c2be0305507f1c1c50347
ToppCellLV-10._Endothelium_II|LV / Chamber and Cluster_Paper

FN1 ADAMTS9 WNT9B PCDH11X

2.20e-04194684b6cc849fa08599bff9839ef382d190cc964e273e
ToppCellIPF-Endothelial|IPF / Disease state, Lineage and Cell class

FAM171A1 DLL4 ADAMTS9 ARHGEF15

2.20e-041946849591993aa2dcba3d09a0f1ea8b8f2439c26482d6
ToppCellEndothelial-endothelial_cell_of_vein|World / Lineage, Cell type, age group and donor

FAM171A1 ADAMTS9 WNT9B ARHGEF15

2.20e-041946843cbd9622a68e89add90e589867d88c83c5a33476
ToppCellILEUM-inflamed-(1)_T_cell-(1)_Tregs|(1)_T_cell / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

RTKN2 TBC1D4 CASP1 CARD16

2.20e-041946840396457834bbfed8d0b9b2ddaaecd9f28e1d56ed
ToppCell390C-Lymphocytic-CD4_T-cell|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

RTKN2 NELL2 TBC1D4 CCR7

2.20e-0419468476c4c3ba5f1bcc39d397c90db3513f5bea632b1b
ToppCellAdult-Endothelial|Adult / Lineage, Cell type, age group and donor

FAM171A1 DLL4 ADAMTS9 ARHGEF15

2.20e-04194684963b3fbee0575af8379baa397ace65949eaf34f7
ToppCellPBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)

NELL2 TBC1D4 RASA3 CCR7

2.20e-04194684a44be2f021cfdd0fcdc698c3f04d66db7a1aa6c2
ToppCelltumor_Lung-T/NK_cells-Treg|T/NK_cells / Location, Cell class and cell subclass

RTKN2 TBC1D4 CASP1 CARD16

2.24e-04195684dd112ef3f8bd0790719827b6bb120918687afdff
ToppCellLPS_only-Endothelial-Endothelial-Activated_Gen_Cap|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

FAM171A1 DLL4 ADAMTS9 ARHGEF15

2.24e-0419568456efeb58df19f357d7d5ce87348d4f196a595421
ToppCellCOVID_non-vent-Lymphocytic-T_cell|COVID_non-vent / Disease condition, Lineage, Cell class and subclass

NELL2 TBC1D4 KAT6A CCR7

2.24e-041956844bdedd924564a260841a9153604026b57487c83d
ToppCell(6)_Endothelial-D|World / Lung cell shreds - cell class (v4) and cell subclass (v4)

FAM171A1 DLL4 ADAMTS9 ARHGEF15

2.24e-04195684c0005a5f2dc63a0cc254c45ac89a2f42df6f8bde
ToppCellAdult-Mesenchymal-matrix_fibroblast_1_cell-D122|Adult / Lineage, Cell type, age group and donor

FN1 PALLD RNF182 CACNA2D3

2.24e-04195684aa0add081881d349099d12efca5cdee098038d4e
ToppCellPBMC-Mild-Lymphocyte-T/NK-CD4+_T|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)

RTKN2 NELL2 TBC1D4 CCR7

2.29e-04196684ffc2728663a72ec62fa2e5b1054368fb56d18c62
ToppCellMild-CD4+_T_activated|Mild / Disease group and Cell class

TBC1D4 CASP1 CARD16 CCR7

2.29e-04196684daa1c3322d81e649161e889e1d78451d2d425d09
ToppCellLPS_IL1RA-Epithelial_alveolar-AT_1-Differentiating_AT2|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

RTKN2 PCDH11X RNF207 FAAH

2.33e-04197684b94645d57efe8d9e032bffb8c89af1f425c6421e
ToppCelltumor_Lung-Endothelial_cells|tumor_Lung / Location, Cell class and cell subclass

FAM171A1 DLL4 ADAMTS9 ARHGEF15

2.33e-041976846870b311c54a73723768276a58456620f5217d43
ToppCellCOVID-19_Severe-Lymphoid_T/NK-CD4+_T_naive|COVID-19_Severe / Disease group, lineage and cell class

NELL2 TBC1D4 KLHL36 CCR7

2.33e-0419768407f74bdadfd28e1d55b3f4a3bf87d5dd65a2e9c5
ToppCell5'-Adult-LymphNode-Hematopoietic-T_cells-Treg|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

RTKN2 TBC1D4 CARD16 CCR7

2.33e-04197684a6eba89bb3e24ae973068f85a8bcc3094e985cb9
ToppCell368C-Endothelial_cells-Endothelial-A_(Artery)|368C / Donor, Lineage, Cell class and subclass (all cells)

FAM171A1 DLL4 ADAMTS9 ARHGEF15

2.33e-041976847caa2c86dc4d50b57a7db8f7278d1588282ad6db
ComputationalGenes upregulated in subsets of cells of a given type within various tumors

RTKN2 TBC1D4 CASP1 CARD16

4.13e-0549434GAVISH_3CA_METAPROGRAM_CD4_T_CELLS_T_REG
DrugAC1N0FHX

KAT6A CASP1 CARD16

1.41e-068683CID003916227
Drug1rww

CASP1 CARD16

8.79e-062682CID005289080
DrugDiphenyl Ether Sulfonamide 10

CASP1 CARD16

8.79e-062682CID009887536
DrugBiphenyl Sulfonamide 1

CASP1 CARD16

8.79e-062682CID010449481
Drug1rwx

CASP1 CARD16

8.79e-062682CID005289610
DrugDiphenyl Ether Sulfonamide 2

CASP1 CARD16

8.79e-062682CID015888281
DrugDiphenyl Ether Sulfonamide 9

CASP1 CARD16

8.79e-062682CID015888283
DrugDiphenyl Ether Sulfonamide 5

CASP1 CARD16

8.79e-062682CID015888282
Drugarylsulfonamide analogue 16

CASP1 CARD16

8.79e-062682CID015888284
DrugDiphenyl Ether Sulfonamide 7

CASP1 CARD16

8.79e-062682CID015888286
Drugarylsulfonamide analogue 11

CASP1 CARD16

8.79e-062682CID015888279
DrugDiphenyl Ether Sulfonamide 12

CASP1 CARD16

8.79e-062682CID010070710
DrugAC1NR9V6

CASP1 CARD16

8.79e-062682CID005287535
DrugAAF-cmk

CASP1 CARD16

8.79e-062682CID006610326
DrugCyclo(lys-pro)

CASP1 CARD16

8.79e-062682CID000194922
DrugAC1NRAF8

CASP1 CARD16

8.79e-062682CID005287849
DrugAa 31

CASP1 CARD16 CCR7

1.68e-0517683CID000191056
DrugLeucomisine [17946-87-1]; Down 200; 16.2uM; MCF7; HT_HG-U133A

FN1 RABGAP1 CHML TNPO3 WIPI2 FAAH

2.50e-051946866767_DN
DrugDinoprost trometamol [38362-01-5]; Up 200; 8.4uM; MCF7; HT_HG-U133A

FN1 RASA3 CENPF CASP1 APC RABGAP1

2.50e-051946863308_UP
DrugDabcyl-ice-edans

CASP1 CARD16

2.63e-053682CID005748518
DrugAC1NBJ9O

CASP1 CARD16

2.63e-053682CID004468934
DrugSulfaphenazole [526-08-9]; Down 200; 12.8uM; MCF7; HT_HG-U133A

TBC1D4 FN1 CENPF SCAPER CASP1 APC

2.72e-051976865507_DN
DrugCeforanide [60925-61-3]; Up 200; 7.6uM; PC3; HT_HG-U133A

KAT6A CASP1 ATP10B CACNA1G CCR7 MYO15A

2.80e-051986866751_UP
DrugDiflorasone Diacetate [33564-31-7]; Up 200; 8uM; MCF7; HT_HG-U133A

FN1 CENPF APC ZMYM2 ATP10B CCR7

2.80e-051986864158_UP
Drug5f-1

FN1 CASP1 CARD16

3.77e-0522683CID015991535
DrugAC1ODTZD

CASP1 CARD16

5.25e-054682CID007020821
DrugAC1NUKW9

CASP1 CARD16

5.25e-054682CID005481610
Drugcinchomeronate

CASP1 CARD16

5.25e-054682CID000010273
DrugAC1L33DC

CASP1 CARD16 GSTO2

7.91e-0528683CID000133757
Drughqc

CASP1 CARD16

8.74e-055682CID005288581
DrugOxeclosporin

CASP1 CARD16

8.74e-055682CID006436153
DrugAc-YVAD-pNA

CASP1 CARD16

8.74e-055682CID000004338
DrugAC1N3S5K

CASP1 CARD16

8.74e-055682CID004117381
DrugPBDA

FN1 CASP1 CARD16

9.76e-0530683CID000004408
Drugfenugreek seed meal

FN1 CASP1

1.31e-046682ctd:C056164
Druglavendustin A

PIK3C3 CASP1 CARD16 CACNA1G CACNA2D3

1.60e-04171685CID000003894
DrugN-Ac-Tyr-Val-Ala-Asp-chloromethyl ketone

CASP1 APC CARD16

1.70e-0436683CID000003722
Drugrupintrivir

CASP1 CARD16

1.83e-047682CID006440352
DrugIsatin analog 1

CASP1 CARD16

1.83e-047682CID000515950
DrugF1-G

CASP1 CARD16

1.83e-047682CID006852193
DrugInhibitor 47c

CASP1 CARD16

1.83e-047682CID005327301
DrugInhibitor 66b

CASP1 CARD16

1.83e-047682CID005327309
Drugcatalpol

CASP1 CARD16

1.83e-047682CID000091520
Drugbestatin methyl ester

CASP1 CARD16

2.43e-048682CID009927170
DrugAc-wehd-cho

CASP1 CARD16

2.43e-048682CID005311140
Drughydrochalcone

CASP1 CARD16

2.43e-048682CID000064802
DrugIsatin Sulfonamide 26

CASP1 CARD16

2.43e-048682CID009800285
DrugM-IBDET

CASP1 CARD16

2.43e-048682CID005464042
Drugdenitro-nipradilol

CASP1 CARD16

2.43e-048682CID000135168
DrugIsatin analog 2

CASP1 CARD16

2.43e-048682CID010826725
DrugAC1L2A54

HEXA ATG7 CASP1 CARD16 TRIM39

2.68e-04191685CID000068636
DrugPropofol [2078-54-8]; Down 200; 22.4uM; MCF7; HT_HG-U133A

RASA3 SCAPER APC RABGAP1 BAHD1

2.68e-041916853386_DN
DrugPF-01378883-00 [351320-41-7]; Up 200; 10uM; PC3; HT_HG-U133A

FN1 APC MUC5B MYO15A WIPI2

2.88e-041946856368_UP
DrugMetronidazole [443-48-1]; Down 200; 23.4uM; MCF7; HT_HG-U133A

FN1 SCAPER CASP1 RABGAP1 CHML

2.88e-041946854141_DN
DrugThiamine hydrochloride [67-03-8]; Down 200; 11.8uM; MCF7; HT_HG-U133A

FN1 ZMYM2 RABGAP1 CHML GAREM1

2.88e-041946857479_DN
Drug(+)-Isoproterenol (+)-bitartrate salt [14638-70-1]; Down 200; 11uM; MCF7; HT_HG-U133A

CENPF SCAPER CASP1 APC WIPI2

2.88e-041946853384_DN
DrugLaudanosine (R,S) [1699-51-0]; Down 200; 11.2uM; HL60; HG-U133A

DHX15 CENPF CASP1 RABGAP1 TARS2

2.88e-041946851741_DN
Drug0393-0188; Up 200; 10uM; MCF7; HT_HG-U133A

CENPF SCAPER CASP1 CHML WIPI2

2.95e-041956857531_UP
Drugrosiglitazone; Up 200; 10uM; MCF7; HT_HG-U133A

CENPF KAT6A CASP1 APC MUC5B

3.02e-041966855230_UP
DrugEdrophonium chloride [116-38-1]; Up 200; 19.8uM; PC3; HT_HG-U133A

RASA3 APC RABGAP1 CHML ARHGEF15

3.02e-041966856655_UP
DrugThioproperazine dimesylate [2347-80-0]; Up 200; 6.2uM; MCF7; HT_HG-U133A

NELL2 RASA3 CENPF ZMYM2 RABGAP1

3.02e-041966852236_UP
DrugSpiramycin [8025-81-8]; Down 200; 4.8uM; PC3; HT_HG-U133A

CENPF KAT6A APC ATP10B BAHD1

3.02e-041966853762_DN
DrugNS-398; Up 200; 10uM; MCF7; HT_HG-U133A

KLHL2 ADAMTS9 CASP1 APC BAHD1

3.02e-041966856911_UP
DrugTerconazole [67915-31-5]; Up 200; 7.6uM; HL60; HT_HG-U133A

NELL2 FN1 KLHL36 ATP10B MYO15A

3.02e-041966852484_UP
DrugAmidopyrine [58-15-1]; Up 200; 17.2uM; MCF7; HT_HG-U133A

FAM171A1 NELL2 FN1 CASP1 MUC5B

3.09e-041976852222_UP
DrugSulfamerazine [127-79-7]; Up 200; 15.2uM; HL60; HT_HG-U133A

FAM171A1 RASA3 KAT6A NAGPA GAREM1

3.09e-041976852181_UP
DrugIsotretinoin [4759-48-2]; Down 200; 13.4uM; MCF7; HT_HG-U133A

ZNF430 KLHL2 CHML FAAH GAREM1

3.09e-041976856017_DN
Drugthiazepine

CASP1 CARD16

3.12e-049682CID012444276
DrugIsatin Sulfonamide 29

CASP1 CARD16

3.12e-049682CID009821545
DrugCpMn

CASP1 CARD16

3.12e-049682CID000146199
DrugHo Chi

CASP1 CARD16

3.12e-049682CID000128142
Drugcaprolactam

CASP1 CARD16

3.12e-049682CID000007768
DrugInhibitor 69b

CASP1 CARD16

3.12e-049682CID005327310
Druginhibitor 59

CASP1 CARD16

3.12e-049682CID005327305
DrugInhibitor 66a

CASP1 CARD16

3.12e-049682CID005327308
DrugInhibitor 64b

CASP1 CARD16

3.12e-049682CID005327307
DrugAC1NS22C

CASP1 CARD16

3.12e-049682CID005327306
DrugSA981

CASP1 CARD16

3.12e-049682CID000054805
DrugOzagrel hydrochloride [78712-43-3]; Up 200; 15.2uM; MCF7; HT_HG-U133A

NELL2 FN1 RASA3 SCAPER ATP10B

3.16e-041986855983_UP
DrugEtodolac [41340-25-4]; Down 200; 14uM; MCF7; HT_HG-U133A

KLHL21 CASP1 TARS2 NAGPA BAHD1

3.16e-041986857006_DN
DrugDoxepin hydrochloride [1229-29-4]; Down 200; 12.6uM; MCF7; HT_HG-U133A

FN1 KLHL21 KAT6A BAHD1 GAREM1

3.16e-041986857415_DN
Drugbutein; Down 200; 10uM; MCF7; HG-U133A

TBC1D4 FN1 ATP10B TNPO3 GAREM1

3.16e-04198685607_DN
DrugNadolol [42200-33-9]; Down 200; 13uM; MCF7; HT_HG-U133A

NELL2 FN1 CASP1 RABGAP1 MYO15A

3.16e-041986854139_DN
DrugSulfinpyrazone [57-96-5]; Up 200; 9.8uM; MCF7; HT_HG-U133A

RASA3 KAT6A CASP1 ZMYM2 GAREM1

3.16e-041986856230_UP
DrugPralidoxime chloride [51-15-0]; Up 200; 23.2uM; HL60; HT_HG-U133A

SCAPER APC PALLD WIPI2 GAREM1

3.24e-041996853066_UP
DrugFluocinonide [356-12-7]; Up 200; 8uM; MCF7; HT_HG-U133A

FN1 ADAMTS9 KAT6A SCAPER CASP1

3.24e-041996853839_UP
Drugginsenoside Rh2

HEXA CASP1 CARD16

3.31e-0445683CID000119307
DrugLetrozole [112809-51-5]; Down 200; 14uM; MCF7; HT_HG-U133A

KLHL21 KAT6A APC BAHD1 GAREM1

3.31e-042006857336_DN
DrugFlucytosine [2022-85-7]; Up 200; 31uM; MCF7; HT_HG-U133A

FN1 CENPF SCAPER ATP10B CCR7

3.31e-042006856450_UP
DrugAC1L1G5B

KAT6A CASP1 CARD16

3.53e-0446683CID000003531
DrugCGP 31362

CASP1 CARD16

3.89e-0410682CID006540671
DiseaseMental Retardation, Psychosocial

HEXA SCAPER APC ZMYM2 CACNA1G

1.77e-05139685C0025363
DiseaseProfound Mental Retardation

HEXA SCAPER APC ZMYM2 CACNA1G

1.77e-05139685C0020796
DiseaseMental deficiency

HEXA SCAPER APC ZMYM2 CACNA1G

1.77e-05139685C0917816
DiseaseIntellectual Disability

HEXA BPTF SCAPER APC ZMYM2 CACNA1G TAF6

7.64e-05447687C3714756
Diseaseguanosine diphosphate measurement

TBC1D4 KCNB2

2.84e-0411682EFO_0010494
Diseasecoronary thrombosis, GM11992

SCAPER PALLD

6.15e-0416682EFO_0001124, EFO_1000883
Diseasefacial morphology measurement

DHX15 FAM171A1 EYS PALLD CACNA2D3 RHOT1

7.19e-04466686EFO_0007841
DiseaseHypermetropia, Myopia

BPTF TNPO3 CACNA2D3 C2CD5

9.64e-04189684HP_0000540, HP_0000545
Diseasesusceptibility to rheumatic fever measurement

KCNB2 CACNA2D3

1.90e-0328682EFO_0008416

Protein segments in the cluster

PeptideGeneStartEntry
ESRNVTDCCEGYEQL

UMODL1

86

Q5DID0
ENIVVYDVCATIDQC

FAM78B

16

Q5VT40
VCLCQDEVTDDYIGD

CCR7

21

P32248
YQSVCLISEERNECV

DLL4

666

Q9NR61
TIYEDCDCSQELCSE

ARHGEF15

751

O94989
DTLAQCEQEEVYDCS

CD5L

101

O43866
IASCDYNCSNEVLSI

DHX15

576

O43143
QSEAELIDEYVCPQC

BPTF

2901

Q12830
LIDEYVCPQCQSTED

BPTF

2906

Q12830
DTVYTINTENQETCE

ATP10B

936

O94823
YSCEEDSCQVRINTT

MUC5B

5651

Q9HC84
VEDSYLSEETCSNVQ

CHML

436

P26374
CYCTVNLDQEEVFRT

RASA3

36

Q14644
YSTCSLCQEENEDVV

NSUN5

356

Q96P11
NNTDTLYEVVCLESE

RABGAP1

466

Q9Y3P9
ICCSSVDQVNDSVYR

FAM171A1

561

Q5VUB5
VVDFCCEYLEQEVSE

KLHL36

131

Q8N4N3
ECSLTETESNYCTQL

KRT28

331

Q7Z3Y7
YTGINCEINLDECLS

EYS

996

Q5T1H1
DDYSCTEHDECITNQ

NELL2

476

Q99435
NCTLQDCSSLEEYNI

SBF2

616

Q86WG5
DECYCQVVKQITDNT

MYO15A

3111

Q9UKN7
NQYTEIETCVECSAK

RHOT1

136

Q8IXI2
SNSDDEECTCVYEFQ

DCAF10

431

Q5QP82
ECNEDTEVYNITLCT

GAREM1

136

Q9H706
ETSQCQLIYESVIAC

GSTO2

76

Q9H4Y5
TVEEASDNCTQECLI

PCDH11X

1131

Q9BZA7
EEETANQEYKVSSCE

PALLD

951

Q8WX93
CEETLAACQTLQSYT

KAT6A

1446

Q92794
SECDQDYIPETDQDC

ADAMTS9

1276

Q9P2N4
QDCDELVTVDCYNPQ

KLHL21

296

Q9UJP4
DCNTHESLLEVCDDY

KCNB2

66

Q92953
QIEALECAYDNLCQT

ATG7

176

O95352
AQACQICITYICEED

CASP1

66

P29466
TLRDCDQESTCYNTV

CACNA1G

1811

O43497
CSVDEVFCSSLQEEN

CENPF

1521

P49454
SISCDDETVNCYLID

CACNA2D3

846

Q8IZS8
DQCIVDDITYNVNDT

FN1

516

P02751
QDQNSVACIEEKCYV

BAHD1

696

Q8TBE0
EQCVRSYETAENEES

GEN1

851

Q17RS7
EDEDCYILNVQSSSD

GCNA

16

Q96QF7
TNCVTSYLADCETQL

FAAH

111

O00519
EIYVTCESDQSVVEC

SCAPER

116

Q9BY12
VYLCQSENSCLEDSD

PKD1L1

381

Q8TDX9
AQACQICITYICEED

CARD16

66

Q5EG05
VVGYSESTSICEEVC

C2CD5

411

Q86YS7
ESVENYTLTINDDQC

HEXA

111

P06865
QIKVEVYSCCTEESS

RTKN2

171

Q8IZC4
IFCTTDQLEAEIQSC

TARS2

461

Q9BW92
IQEETCQLLTDEVSY

TAF6

31

P49848
CDLECSEQDVETTYF

RNF207

101

Q6ZRF8
ENLQVEASCSVCLEY

TRIM39

21

Q9HCM9
QETCSDLYVTCQVFA

PIK3C3

51

Q8NEB9
IYINESQATECDETQ

NAGPA

211

Q9UK23
QIYECTDTEDVCIVE

WIPI2

66

Q9Y4P8
ESQASDELECKICYN

RNF182

11

Q8N6D2
QETIQTYCVEDTPIC

APC

1256

P25054
DEEEQQYVIKCGTCT

ZNF451

781

Q9Y4E5
TELQLDLESCYAQVC

TMEM102

131

Q8N9M5
VDEALCACEEYLSNL

TTLL3

196

Q9Y4R7
VLQDELQESSYSCED

TBC1D4

1181

O60343
SDCVCSALYAIENVE

TNPO3

246

Q9Y5L0
CEYCQEEKTLHETVN

ZMYM2

681

Q9UBW7
CYDELNQCLTTTQSE

ZNF430

161

Q9H8G1
VECQQCVQEELVYTC

WNT9B

341

O14905
CCVVQEEASPYTLVN

ZYG11A

26

Q6WRX3
VYCQQTLCTSELFED

TERB1

91

Q8NA31
ESTEVECYDSLTACL

TTC9B

131

Q8N6N2
QCLSTVECYNATTNE

KLHL2

461

O95198