Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	nucleoside-triphosphatase regulator activity	RAB3GAP1 RIN3 RASAL3 RGL2 MYO9B SH2D3A SYNGAP1	1.48e-04	507	46	7	GO:0060589
GeneOntologyMolecularFunction	GTPase regulator activity	RAB3GAP1 RIN3 RASAL3 RGL2 MYO9B SH2D3A SYNGAP1	1.48e-04	507	46	7	GO:0030695
GeneOntologyMolecularFunction	GTPase activator activity	RAB3GAP1 RIN3 RASAL3 MYO9B SYNGAP1	4.41e-04	279	46	5	GO:0005096
GeneOntologyCellularComponent	centriole	CCDC120 PPP1R35 RAB34 TOP2A	4.65e-04	172	44	4	GO:0005814
GeneOntologyCellularComponent	axon	NGF CCDC120 DLG3 DPYSL2 RIN3 RET PTPRF TULP1	4.78e-04	891	44	8	GO:0030424
MousePheno	increased neuron apoptosis	PIANP RET RB1 APC2 SYNGAP1	2.29e-05	143	34	5	MP:0003203
Domain	RA	RASSF5 RIN3 RGL2 MYO9B	8.82e-07	31	45	4	SM00314
Domain	RA	RASSF5 RIN3 RGL2 MYO9B	1.83e-06	37	45	4	PS50200
Domain	RA_dom	RASSF5 RIN3 RGL2 MYO9B	2.52e-06	40	45	4	IPR000159
Domain	RA	RASSF5 RGL2 MYO9B	8.83e-05	36	45	3	PF00788
Domain	RasGAP	RASAL3 SYNGAP1	5.07e-04	14	45	2	SM00323
Domain	RasGAP_CS	RASAL3 SYNGAP1	5.07e-04	14	45	2	IPR023152
Domain	RAS_GTPASE_ACTIV_2	RASAL3 SYNGAP1	5.84e-04	15	45	2	PS50018
Domain	RasGAP	RASAL3 SYNGAP1	5.84e-04	15	45	2	PF00616
Domain	RAS_GTPASE_ACTIV_1	RASAL3 SYNGAP1	5.84e-04	15	45	2	PS00509
Domain	-	RASAL3 SYNGAP1	6.67e-04	16	45	2	1.10.506.10
Domain	RasGAP_dom	RASAL3 SYNGAP1	8.47e-04	18	45	2	IPR001936
Domain	Rho_GTPase_activation_prot	RASAL3 MYO9B SYNGAP1	1.24e-03	88	45	3	IPR008936
Domain	AT_hook	PRR12 SRCAP	1.92e-03	27	45	2	SM00384
Domain	AT_hook_DNA-bd_motif	PRR12 SRCAP	1.92e-03	27	45	2	IPR017956
Domain	RasGEF	RGL2 SH2D3A	2.37e-03	30	45	2	PF00617
Domain	-	RGL2 SH2D3A	2.37e-03	30	45	2	1.10.840.10
Domain	Ras_GEF_dom	RGL2 SH2D3A	2.37e-03	30	45	2	IPR023578
Domain	RASGEF_cat_dom	RGL2 SH2D3A	2.37e-03	30	45	2	IPR001895
Domain	RasGEF	RGL2 SH2D3A	2.37e-03	30	45	2	SM00147
Domain	C2	RASAL3 C2CD5 SYNGAP1	4.83e-03	142	45	3	PS50004
Domain	-	RASAL3 C2CD5 SYNGAP1	5.42e-03	148	45	3	2.60.40.150
Domain	C2_dom	RASAL3 C2CD5 SYNGAP1	7.20e-03	164	45	3	IPR000008
Pathway	WP_BRAINDERIVED_NEUROTROPHIC_FACTOR_BDNF_SIGNALING	FRS3 NGF DPYSL2 PTPRF MAP3K1	1.67e-05	144	32	5	M39691
Pathway	REACTOME_MAPK_FAMILY_SIGNALING_CASCADES	FRS3 DLG3 RET RASAL3 RGL2 SYNGAP1	6.94e-05	318	32	6	MM15278
Pathway	REACTOME_MAPK_FAMILY_SIGNALING_CASCADES	FRS3 DLG3 RET RASAL3 RGL2 SYNGAP1	8.10e-05	327	32	6	M27565
Pathway	BIOCARTA_BTG2_PATHWAY	NGF RB1	2.22e-04	10	32	2	MM1540
Pathway	BIOCARTA_BTG2_PATHWAY	NGF RB1	2.71e-04	11	32	2	M22014
Pubmed	Oncogenic RET receptors display different autophosphorylation sites and substrate binding specificities.	RET PTPRF	1.79e-06	2	47	2	8621380
Pubmed	The retinoblastoma tumor suppressor protein is required for efficient processing and repair of trapped topoisomerase II-DNA-cleavable complexes.	RB1 TOP2A	1.79e-06	2	47	2	16091739
Pubmed	Ras Regulates Rb via NORE1A.	RASSF5 RB1	1.79e-06	2	47	2	26677227
Pubmed	Differential effects of leukocyte common antigen-related protein on biochemical and biological activities of RET-MEN2A and RET-MEN2B mutant proteins.	RET PTPRF	1.79e-06	2	47	2	11121408
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	PRR12 PDCD11 RIN3 FAM110A SRCAP MBD6 PTPRF RGL2 MYO9B ANO8	1.79e-06	1105	47	10	35748872
Pubmed	SynGAP: a synaptic RasGAP that associates with the PSD-95/SAP90 protein family.	DLG3 SYNGAP1	5.36e-06	3	47	2	9581761
Pubmed	Rb and p130 control cell cycle gene silencing to maintain the postmitotic phenotype in cardiac myocytes.	RAB3GAP1 RB1	5.36e-06	3	47	2	21825075
Pubmed	Functional interaction between human topoisomerase IIalpha and retinoblastoma protein.	RB1 TOP2A	5.36e-06	3	47	2	10393912
Pubmed	Germline RET variants underlie a subset of paediatric osteosarcoma.	RET RB1	5.36e-06	3	47	2	32179705
Pubmed	DNA topoisomerases participate in fragility of the oncogene RET.	RET TOP2A	5.36e-06	3	47	2	24040417
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	PDCD11 NSUN5 DPYSL2 RAB3GAP1 RAB34 SRCAP RB1 MYO9B THRAP3 TOP2A	1.07e-05	1353	47	10	29467282
Pubmed	TNF-α/TNFR1 signaling is required for the development and function of primary nociceptors.	NGF RET	1.07e-05	4	47	2	24811380
Pubmed	HMGB1 and HMGB2 proteins up-regulate cellular expression of human topoisomerase IIalpha.	RB1 TOP2A	1.78e-05	5	47	2	19223331
Pubmed	Maturation of ureter-bladder connection in mice is controlled by LAR family receptor protein tyrosine phosphatases.	RET PTPRF	2.67e-05	6	47	2	19273906
Pubmed	Gene and pseudogene of the mouse cation-dependent mannose 6-phosphate receptor. Genomic organization, expression, and chromosomal localization.	NGF RET	4.98e-05	8	47	2	1376319
Pubmed	High-resolution photocatalytic mapping of SARS-CoV-2 spike interactions on the cell surface.	PTOV1 CCDC120 RAB34 PTPRF THRAP3	5.87e-05	307	47	5	37499664
Pubmed	Sema3A chemorepellant regulates the timing and patterning of dental nerves during development of incisor tooth germ.	NGF RET	6.40e-05	9	47	2	24752460
Pubmed	Global mapping of herpesvirus-host protein complexes reveals a transcription strategy for late genes.	RAB3GAP1 RB1 RGL2 THRAP3 DDX28 C2CD5	7.94e-05	533	47	6	25544563
Pubmed	FRS2 proteins recruit intracellular signaling pathways by binding to diverse targets on fibroblast growth factor and nerve growth factor receptors.	FRS3 NGF	7.99e-05	10	47	2	10629055
Pubmed	An evolving NGF-Hoxd1 signaling pathway mediates development of divergent neural circuits in vertebrates.	NGF RET	9.75e-05	11	47	2	21151121
Pubmed	From Nf1 to Sdhb knockout: Successes and failures in the quest for animal models of pheochromocytoma.	RET RB1	9.75e-05	11	47	2	26123588
Pubmed	MKRN2 Physically Interacts with GLE1 to Regulate mRNA Export and Zebrafish Retinal Development.	DPYSL2 CDT1 RB1 THRAP3 TOP2A	1.21e-04	358	47	5	32460013
Pubmed	LIG family receptor tyrosine kinase-associated proteins modulate growth factor signals during neural development.	NGF RET	1.61e-04	14	47	2	19755105
Pubmed	Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.	DLG3 NSUN5 ANOS1 FAM110A MYO9B TULP1 NDST2 SYNGAP1	2.03e-04	1215	47	8	15146197
Pubmed	The goya mouse mutant reveals distinct newly identified roles for MAP3K1 in the development and survival of cochlear sensory hair cells.	RB1 MAP3K1	2.40e-04	17	47	2	26542706
Pubmed	RNF168 and USP10 regulate topoisomerase IIα function via opposing effects on its ubiquitylation.	PDCD11 TOP2A	2.70e-04	18	47	2	27558965
Pubmed	Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.	RET RASAL3 MAP3K1 APC2 SYNGAP1	2.82e-04	430	47	5	35044719
Pubmed	Genes, plasticity and mental retardation.	DLG3 RAB3GAP1	3.01e-04	19	47	2	18329113
Pubmed	Identification of novel human Cdt1-binding proteins by a proteomics approach: proteolytic regulation by APC/CCdh1.	CDT1 TOP2A	3.34e-04	20	47	2	18162579
Pubmed	A hierarchical NGF signaling cascade controls Ret-dependent and Ret-independent events during development of nonpeptidergic DRG neurons.	NGF RET	4.84e-04	24	47	2	17553423
Pubmed	SALM4 suppresses excitatory synapse development by cis-inhibiting trans-synaptic SALM3-LAR adhesion.	DLG3 SYNGAP1	5.26e-04	25	47	2	27480238
Pubmed	Comparative analysis of 1196 orthologous mouse and human full-length mRNA and protein sequences.	RET RB1	5.26e-04	25	47	2	8889551
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	PRR12 RAB3GAP1 PTCD1 C2CD5 ANO8	5.27e-04	493	47	5	15368895
Pubmed	The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis.	PDCD11 NSUN5 MYO9B TOP2A DDX28 MAP3K1	5.31e-04	759	47	6	35915203
Pubmed	Molecular profiles of mitogen activated protein kinase signaling pathways in orofacial development.	RB1 MAP3K1	5.69e-04	26	47	2	17177285
Pubmed	Human origin recognition complex large subunit is degraded by ubiquitin-mediated proteolysis after initiation of DNA replication.	CDT1 RB1	5.69e-04	26	47	2	11931757
Pubmed	Full-length transcriptome analysis of human retina-derived cell lines ARPE-19 and Y79 using the vector-capping method.	SRCAP PTPRF TULP1	5.81e-04	120	47	3	21697133
Pubmed	Proteomic identification of the MYST domain histone acetyltransferase TIP60 (HTATIP) as a co-activator of the myeloid transcription factor C/EBPalpha.	RAB34 RB1	7.09e-04	29	47	2	18239623
Pubmed	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.	PDCD11 NSUN5 PTCD1 THRAP3 TOP2A DDX28	7.32e-04	807	47	6	22681889
Pubmed	Biological insights from 108 schizophrenia-associated genetic loci.	PRR12 PDCD11 PTPRF DDX28	7.50e-04	303	47	4	25056061
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	PRR12 PDCD11 DLG3 NSUN5 FAM110A PTCD1 PIGK DDX28	8.13e-04	1497	47	8	31527615
Pubmed	Comparative interactome analysis of α-arrestin families in human and Drosophila.	PTPRF THRAP3 DDX28 C2CD5	8.46e-04	313	47	4	38270169
Pubmed	SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.	PDCD11 DPYSL2 SRCAP THRAP3 TOP2A	8.55e-04	549	47	5	38280479
Pubmed	Negative regulation of EGFR signalling by the human folliculin tumour suppressor protein.	RAB3GAP1 RAB34	8.64e-04	32	47	2	28656962
Pubmed	Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage.	DPYSL2 PTCD1 MYO9B THRAP3 TOP2A MAP3K1	9.23e-04	844	47	6	25963833
Pubmed	Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening.	RIN3 FAM110A RGL2 TULP1	1.02e-03	329	47	4	17474147
Pubmed	Biological, clinical and population relevance of 95 loci for blood lipids.	RAB3GAP1 LILRA3 MAP3K1	1.03e-03	146	47	3	20686565
Pubmed	The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery.	RAB34 PTPRF RB1 PIGK THRAP3 TOP2A SYNGAP1	1.09e-03	1203	47	7	29180619
Pubmed	Gene content of the 750-kb critical region for mouse embryonic ectoderm lethal tcl-w5.	EFHB RGL2	1.09e-03	36	47	2	15112104
Pubmed	Serum response factor mediates NGF-dependent target innervation by embryonic DRG sensory neurons.	NGF RET	1.16e-03	37	47	2	18498735
Pubmed	Heart neurons use clock genes to control myocyte proliferation.	NGF TOP2A	1.16e-03	37	47	2	34851661
Interaction	MAPK9 interactions	TUSC2 CCDC120 RIN3 CDT1 RB1 MAP3K1	4.47e-06	186	47	6	int:MAPK9
Cytoband	19q13.33	PTOV1 PRR12 C19orf73	1.80e-04	106	47	3	19q13.33
Cytoband	Xq13.1	DLG3 RTL5	1.12e-03	48	47	2	Xq13.1
Cytoband	Ensembl 112 genes in cytogenetic band chr19p13	RASAL3 MYO9B ANO8 APC2 SH2D3A	1.31e-03	797	47	5	chr19p13
Cytoband	Ensembl 112 genes in cytogenetic band chr7q22	PPP1R35 SLC12A9 PTCD1	1.49e-03	219	47	3	chr7q22
Cytoband	Ensembl 112 genes in cytogenetic band chr6p21	FRS3 RGL2 TULP1 SYNGAP1	1.75e-03	503	47	4	chr6p21
Cytoband	6p21.3	RGL2 TULP1 SYNGAP1	2.17e-03	250	47	3	6p21.3
Cytoband	7q22.1	PPP1R35 PTCD1	6.04e-03	113	47	2	7q22.1
GeneFamily	Pleckstrin homology domain containing\|SH2 domain containing\|C2 and RasGAP domain containing	RASAL3 SYNGAP1	1.11e-04	10	29	2	830
Coexpression	THAKAR_PBMC_INACTIVATED_INFLUENZA_AGE_21_30YO_RESPONDERS_28DY_DN	FRS3 NSUN5 LILRA3 PPP1R35 RASAL3 MBD6 SLC12A9 PTCD1 MYO9B NDST2	3.72e-06	905	47	10	M40865
Coexpression	GSE25088_CTRL_VS_IL4_AND_ROSIGLITAZONE_STIM_MACROPHAGE_UP	RAB3GAP1 TSPYL4 TOP2A MAP3K1 SH2D3A	2.58e-05	195	47	5	M7926
Coexpression	GSE9960_HEALTHY_VS_SEPSIS_PBMC_UP	TUSC2 PTPRF PTCD1 TOP2A APC2	2.58e-05	195	47	5	M7125
Coexpression	GSE14308_TH1_VS_NAIVE_CD4_TCELL_DN	DLG3 SRCAP RGL2 THRAP3 MAP3K1	2.91e-05	200	47	5	M3377
ToppCell	Control-Developping_Plasmablast\|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)	ANOS1 CDT1 RET TOP2A	7.86e-06	120	47	4	695dab6b01ad2c33cdcaf92bb9996ff2899ef77e
ToppCell	LPS-IL1RA+antiTNF-Epithelial_alveolar-Mes-like\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	CDT1 RASAL3 TOP2A DDX28	2.62e-05	163	47	4	360cd65decda24853124f33a174f5224d7f3ce23
ToppCell	LPS-IL1RA+antiTNF-Epithelial_alveolar-Mes-like-AT1_Progenitor\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	CDT1 RASAL3 TOP2A DDX28	2.62e-05	163	47	4	b59d9b4f7c9f4e5e2c7783a49a96729dae3a81e5
ToppCell	5'-Adult-LargeIntestine-Hematopoietic-T_cells-Th17\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	RASSF5 PIANP RASAL3 ANO8	2.95e-05	168	47	4	97bf074b91c9ae0064edc31fa4a2658ffdcfefa3
ToppCell	facs-Aorta-Heart-3m-Myeloid\|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RASSF5 PIANP RASAL3 TOP2A	3.31e-05	173	47	4	513b4d31bcfb269556c6b4cc389865fb12e52c4f
ToppCell	droplet-Fat-Mat-18m-Hematologic-monocyte\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RASSF5 RIN3 FAM110A TOP2A	3.54e-05	176	47	4	867936a20f73f638055c19c8d88834aa2cc657cf
ToppCell	droplet-Liver-Hepatocytes-21m-Myeloid-Kupffer_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RASSF5 PIANP RAB34 TSPYL4	3.54e-05	176	47	4	8e89471f838ea81235256cc2470f1c12c9b75f8a
ToppCell	5'-GW_trimst-1.5-SmallIntestine-Hematopoietic-Myeloid-CLC+_Mast_cell\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	RASSF5 FAM110A RASAL3 NDST2	3.54e-05	176	47	4	183ba1aa5cf594b88ec08e0e41241668b51256a9
ToppCell	facs-Aorta-Heart-3m-Myeloid-macrophage\|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RASSF5 PIANP RASAL3 TOP2A	4.03e-05	182	47	4	df26388c0c46d1c4775103c8e802937b4d4e7470
ToppCell	facs-Aorta-Heart-3m-Myeloid-leukocyte\|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RASSF5 PIANP RASAL3 TOP2A	4.12e-05	183	47	4	062ec08d66c923f90fee771b1bf8d98bdc7e6c1b
ToppCell	nucseq-Immune-Immune_Myeloid-pMON-pMON\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	RIN3 FAM110A MYO9B MAP3K1	5.17e-05	194	47	4	e237384b02be460d44eeada3026a5691c66f6fc1
ToppCell	nucseq-Immune-Immune_Myeloid-pMON\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	RIN3 FAM110A MYO9B MAP3K1	5.17e-05	194	47	4	0bc83ae79873a5e473e6e1e3111924cd003986a1
ToppCell	(08)_PNEC\|World / shred by cell type and Timepoint	NGF DPYSL2 RET TSPYL4	5.38e-05	196	47	4	2ee37155c03cd5009427a4bffe6c80ed2ac6939e
ToppCell	LPS_IL1RA-Epithelial_alveolar-AT_1-Differentiating_AT2\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	ANOS1 PTPRF SLC12A9 SH2D3A	5.49e-05	197	47	4	b94645d57efe8d9e032bffb8c89af1f425c6421e
ToppCell	Fetal_brain-fetalBrain_Zhong_nature-GW08-Neuronal-GABAergic_neurons\|GW08 / Sample Type, Dataset, Time_group, and Cell type.	PPP1R35 SRCAP PTPRF DDX28	5.49e-05	197	47	4	e1a80c1aa7f7e83f5d19a40fe37db5c5a6c25685
ToppCell	Parenchymal-10x3prime_v2-Immune_Lymphocytic-NK-ILC-T_NK-NK_CD11d\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	RASSF5 RASAL3 TOP2A NDST2	5.49e-05	197	47	4	52246d1354c4e2b13d48c878643edf843d2b50d2
ToppCell	LPS_IL1RA-Epithelial_alveolar-AT_1\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	ANOS1 PTPRF SLC12A9 SH2D3A	5.71e-05	199	47	4	a270630626df614f8605abddb7dee7c4d74f6149
ToppCell	LPS_anti-TNF-Epithelial_alveolar-AT_1-Differentiating_AT1\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	ANOS1 PTPRF SLC12A9 SH2D3A	5.71e-05	199	47	4	d43c605a4ff221cf78d91678c15d2ad20f831c7f
ToppCell	Brain_organoid-organoid_Paulsen_bioRxiv-1_mon-Proliferating-Cycling_Progenitors\|1_mon / Sample Type, Dataset, Time_group, and Cell type.	CDT1 PTPRF RB1 TOP2A	5.71e-05	199	47	4	358c4b3037f59378db8916a2fbe9ed4830cf1449
ToppCell	critical-Epithelial-FOXN4+\|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	DPYSL2 CDT1 RB1 TOP2A	5.82e-05	200	47	4	f39db4250ce220a3eb58edee3f7fc3671701d46f
ToppCell	Bronchial-10x5prime-Immune_Myeloid-Monocytic-Monocyte_CD16\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	RASSF5 RIN3 FAM110A MAP3K1	5.82e-05	200	47	4	d39bf03817b76c9dfcbcd868341b51bb8601ea9b
ToppCell	LPS_anti-TNF-Epithelial_alveolar-AT_1\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	ANOS1 PTPRF SLC12A9 SH2D3A	5.82e-05	200	47	4	8683445ad5b70748c4a1f12eb77d47623085147e
ToppCell	Parenchymal-10x3prime_v2-Epithelial-Epi_alveolar-Dividing_AT2\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	DLG3 CDT1 TOP2A SH2D3A	5.82e-05	200	47	4	befc25cbcbac2c02e5fd33d6e78e59979050090c
Disease	developmental disorder of mental health (implicated_via_orthology)	DLG3 RASAL3 SRCAP SYNGAP1	6.49e-07	49	41	4	DOID:0060037 (implicated_via_orthology)
Disease	Adrenocortical carcinoma	RB1 TOP2A	2.84e-04	18	41	2	C0206686
Disease	cancer (implicated_via_orthology)	DLG3 RET RB1 TOP2A	5.17e-04	268	41	4	DOID:162 (implicated_via_orthology)
Disease	breast cancer, lung cancer	RIN3 MAP3K1	5.54e-04	25	41	2	MONDO_0007254, MONDO_0008903
Disease	azoospermia (implicated_via_orthology)	PTPRF NDST2	6.47e-04	27	41	2	DOID:14227 (implicated_via_orthology)
Disease	autism spectrum disorder (implicated_via_orthology)	PIANP NDST2 SYNGAP1	1.24e-03	152	41	3	DOID:0060041 (implicated_via_orthology)
Disease	ductal carcinoma in situ (is_marker_for)	RB1 TOP2A	1.35e-03	39	41	2	DOID:0060074 (is_marker_for)

Protein segments in the cluster

Peptide	Gene	Start	Entry
VTDFFARRRPGPPRI	CDT1	6	Q9H211
PRPQFRGVRRISPIT	ANO8	326	Q9HCE9
TAVIPINGSPRTPRR	RB1	241	P06400
RPLRRPRPVQRTQSV	RASAL3	806	Q86YV0
GREFILRTTVPRPAP	RAB3GAP1	936	Q15042
LRRPVTVPAGIRPQS	RASSF5	246	Q8WWW0
FARRGVRRPNPSVPS	KIRREL3-AS3	96	Q8N7Y1
SRPGPASQLPRFVRV	NSUN5	126	Q96P11
QRRRPTRPLEVGAPF	ANOS1	421	P23352
PSQRRPRRPPTVFRL	MBD6	361	Q96DN6
RLRSPRVLFSTQPPR	NGF	81	P01138
PRRTTQRIVAPPGGR	DPYSL2	551	Q16555
GERPQLVRRRPPTAR	CCDC120	76	Q96HB5
VRRVDVRPLPASPAR	FAM110A	151	Q9BQ89
SRRRNLPRPVLVRPG	DDX28	51	Q9NUL7
FLRVLTGRIPPSTPR	PIGK	131	Q92643
GRPPRPLVVRAVRSR	PTOV1	21	Q86YD1
SPVRIPFMQRPARRG	APC2	1926	O95996
FPVPLTRRRGSPRVF	FRS3	386	O43559
TPTQTVVRPAGFPRR	C19orf73	51	Q9NVV2
AGPVVRLVVRRRQPP	DLG3	206	Q92796
GVPTIRSDIPAPRIR	EFHB	721	Q8N7U6
IGSPIPEPRQRSRLL	C2CD5	641	Q86YS7
QIRARPFLSVRPGPT	LILRA3	321	Q8N6C8
RVRRVAPRFSIPPSS	PTPRF	226	P10586
NLPTAPPRRRVSERV	RIN3	381	Q8TB24
SPGVRRKRVSPVPFQ	MAP3K1	266	Q13233
RQVRRRPPVLFRLTP	RTL5	541	Q5HYW3
GEVTIRPLRPPQRAR	RGL2	316	O15211
PRVPRSRRQVLPGTA	PIANP	71	Q8IYJ0
RRQVRFRLTPPSPVR	PPP1R35	76	Q8TAP8
RGRPRIRPLEVPTTA	PRR12	1171	Q9ULL5
TPRRRPGPRRLVGTT	SRCAP	3186	Q6ZRS2
PREFVLRPAPQGRTV	TULP1	291	O00294
RPIFLQPGRPLTRLS	PDCD11	346	Q14690
QSVVVRRRSPRPSPV	THRAP3	256	Q9Y2W1
PTVSPVTRPRVVARG	nan	101	P0C879
RQSERPRPQPVVLRG	SYNGAP1	736	Q96PV0
RGFRALPITQPTPRG	SARG	81	Q9BW04
EVFRVALRPRPGRPT	SH2D3A	61	Q9BRG2
FVAVGPRDIRLTPRP	SLC12A9	211	Q9BXP2
ALVRPRGRAVPPFVF	TUSC2	31	O75896
RGPPRQPVESARSFR	TSPYL4	396	Q9UJ04
AVPGPVLRRARLPTV	NDST2	251	P52849
RPSFRIRENRPPGTF	RET	171	P07949
LPSPRGQRVIPRITI	TOP2A	1211	P11388
ATVLQPPVSRQRPRR	PTCD1	351	O75127
GQVTRIPPVRTVRRA	nan	61	Q6ZSA8
VGSPRPRVIVGTIRP	RAB34	11	P0DI83
PRPRVIFGTPRARVI	RAB34	61	P0DI83
AAPPRRRPSSFVTVR	MYO9B	2041	Q13459