Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	ATPase-coupled transmembrane transporter activity	TCIRG1 ABCD1 ABCA4 ABCD2	4.83e-05	109	37	4	GO:0042626
GeneOntologyMolecularFunction	adenosine 3',5'-bisphosphate transmembrane transporter activity	SLC25A42 ABCD1	4.99e-05	6	37	2	GO:0071077
GeneOntologyMolecularFunction	ABC-type transporter activity	ABCD1 ABCA4 ABCD2	1.02e-04	49	37	3	GO:0140359
GeneOntologyMolecularFunction	active transmembrane transporter activity	TCIRG1 SLC25A42 ABCD1 ABCA4 ABCD2 SLC6A14	2.23e-04	477	37	6	GO:0022804
GeneOntologyMolecularFunction	primary active transmembrane transporter activity	TCIRG1 ABCD1 ABCA4 ABCD2	3.20e-04	178	37	4	GO:0015399
GeneOntologyMolecularFunction	lipid transmembrane transporter activity	ABCD1 ABCA4 ABCD2	3.33e-04	73	37	3	GO:0170055
GeneOntologyMolecularFunction	long-chain fatty acid transmembrane transporter activity	ABCD1 ABCD2	5.02e-04	18	37	2	GO:0005324
GeneOntologyMolecularFunction	fatty acid transmembrane transporter activity	ABCD1 ABCD2	8.25e-04	23	37	2	GO:0015245
GeneOntologyMolecularFunction	purine ribonucleotide transmembrane transporter activity	SLC25A42 ABCD1	8.25e-04	23	37	2	GO:0005346
GeneOntologyMolecularFunction	ATP-dependent activity	TCIRG1 KATNAL2 ABCD1 ABCA4 MYO15A ABCD2	8.51e-04	614	37	6	GO:0140657
GeneOntologyMolecularFunction	adenine nucleotide transmembrane transporter activity	SLC25A42 ABCD1	1.06e-03	26	37	2	GO:0000295
GeneOntologyMolecularFunction	fatty acyl-CoA hydrolase activity	ABCD1 ABCD2	1.14e-03	27	37	2	GO:0047617
GeneOntologyMolecularFunction	acyl-CoA hydrolase activity	ABCD1 ABCD2	1.23e-03	28	37	2	GO:0016289
GeneOntologyMolecularFunction	purine nucleotide transmembrane transporter activity	SLC25A42 ABCD1	1.31e-03	29	37	2	GO:0015216
GeneOntologyMolecularFunction	nucleotide transmembrane transporter activity	SLC25A42 ABCD1	1.70e-03	33	37	2	GO:0015215
GeneOntologyMolecularFunction	organic anion transmembrane transporter activity	SLC25A42 ABCD1 ABCD2 SLC6A14	2.05e-03	293	37	4	GO:0008514
GeneOntologyMolecularFunction	organophosphate ester transmembrane transporter activity	SLC25A42 ABCD1	2.37e-03	39	37	2	GO:0015605
GeneOntologyMolecularFunction	thiolester hydrolase activity	ABCD1 ABCD2	3.43e-03	47	37	2	GO:0016790
GeneOntologyMolecularFunction	carbohydrate derivative transmembrane transporter activity	SLC25A42 ABCD1	5.35e-03	59	37	2	GO:1901505
GeneOntologyMolecularFunction	nucleobase-containing compound transmembrane transporter activity	SLC25A42 ABCD1	5.35e-03	59	37	2	GO:0015932
GeneOntologyMolecularFunction	lipid transporter activity	ABCD1 ABCA4 ABCD2	5.66e-03	196	37	3	GO:0005319
GeneOntologyMolecularFunction	transmembrane receptor protein tyrosine kinase activity	KDR FGFR1	6.46e-03	65	37	2	GO:0004714
GeneOntologyMolecularFunction	carboxylic acid transmembrane transporter activity	ABCD1 ABCD2 SLC6A14	6.58e-03	207	37	3	GO:0046943
GeneOntologyMolecularFunction	organic acid transmembrane transporter activity	ABCD1 ABCD2 SLC6A14	6.67e-03	208	37	3	GO:0005342
GeneOntologyMolecularFunction	ATP hydrolysis activity	KATNAL2 ABCD1 ABCA4 ABCD2	8.71e-03	441	37	4	GO:0016887
GeneOntologyBiologicalProcess	regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	OBSCN KDR FGFR1 BTN2A1 SEMA3E BTN2A3P CNTNAP2	1.25e-06	334	35	7	GO:0051896
GeneOntologyBiologicalProcess	phosphatidylinositol 3-kinase/protein kinase B signal transduction	OBSCN KDR FGFR1 BTN2A1 SEMA3E BTN2A3P CNTNAP2	3.04e-06	382	35	7	GO:0043491
GeneOntologyBiologicalProcess	negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	OBSCN BTN2A1 BTN2A3P CNTNAP2	1.34e-05	86	35	4	GO:0051898
GeneOntologyBiologicalProcess	long-chain fatty acid import into peroxisome	ABCD1 ABCD2	1.67e-05	4	35	2	GO:0015910
GeneOntologyBiologicalProcess	very long-chain fatty acid catabolic process	ABCD1 ABCD2	5.84e-05	7	35	2	GO:0042760
GeneOntologyBiologicalProcess	positive regulation of unsaturated fatty acid biosynthetic process	ABCD1 ABCD2	1.52e-04	11	35	2	GO:2001280
GeneOntologyBiologicalProcess	positive regulation of fatty acid beta-oxidation	ABCD1 ABCD2	2.16e-04	13	35	2	GO:0032000
GeneOntologyBiologicalProcess	neuron projection maintenance	ABCD1 ABCD2	2.16e-04	13	35	2	GO:1990535
MousePheno	increased response to antigen	BTN2A1 BTN2A3P	7.10e-05	6	31	2	MP:0020002
MousePheno	astrocytosis	ABCD1 ABCD2 ASAH1 CNTNAP2	7.51e-05	103	31	4	MP:0003354
MousePheno	increased astrocyte number	ABCD1 ABCD2 ASAH1 CNTNAP2	8.71e-05	107	31	4	MP:0012065
MousePheno	decreased circulating interleukin-1 alpha level	MMP25 SLC6A14	9.93e-05	7	31	2	MP:0008639
MousePheno	abnormal astrocyte number	ABCD1 ABCD2 ASAH1 CNTNAP2	1.04e-04	112	31	4	MP:0012064
Domain	ABC_membrane_2	ABCD1 ABCD2	2.04e-05	4	35	2	PF06472
Domain	ABC_transporter_CS	ABCD1 ABCA4 ABCD2	6.58e-05	42	35	3	IPR017871
Domain	ABC_TRANSPORTER_2	ABCD1 ABCA4 ABCD2	9.84e-05	48	35	3	PS50893
Domain	ABC_tran	ABCD1 ABCA4 ABCD2	9.84e-05	48	35	3	PF00005
Domain	ABC_TRANSPORTER_1	ABCD1 ABCA4 ABCD2	1.05e-04	49	35	3	PS00211
Domain	ABC_transporter-like	ABCD1 ABCA4 ABCD2	1.11e-04	50	35	3	IPR003439
Domain	AAA+_ATPase	KATNAL2 ABCD1 ABCA4 ABCD2	1.47e-04	144	35	4	IPR003593
Domain	AAA	KATNAL2 ABCD1 ABCA4 ABCD2	1.47e-04	144	35	4	SM00382
Domain	IG_LIKE	OBSCN KDR FGFR1 BTN2A1 SEMA3E BTN2A3P	2.72e-04	491	35	6	PS50835
Domain	Ig-like_dom	OBSCN KDR FGFR1 BTN2A1 SEMA3E BTN2A3P	3.09e-04	503	35	6	IPR007110
Domain	IGv	OBSCN BTN2A1 BTN2A3P	3.71e-04	75	35	3	SM00406
Domain	ig	OBSCN KDR FGFR1 SEMA3E	4.25e-04	190	35	4	PF00047
Domain	Immunoglobulin	OBSCN KDR FGFR1 SEMA3E	4.25e-04	190	35	4	IPR013151
Domain	Ig_V-set	OBSCN KDR BTN2A1 BTN2A3P	5.06e-04	199	35	4	IPR013106
Domain	PROTEIN_KINASE_TYR	OBSCN KDR FGFR1	7.88e-04	97	35	3	PS00109
Domain	Tyr_kinase_AS	OBSCN KDR FGFR1	7.88e-04	97	35	3	IPR008266
Domain	IG	OBSCN KDR FGFR1 BTN2A1 SEMA3E	1.06e-03	421	35	5	SM00409
Domain	Ig_sub	OBSCN KDR FGFR1 BTN2A1 SEMA3E	1.06e-03	421	35	5	IPR003599
Domain	ABC_TM1F	ABCD1 ABCD2	1.25e-03	28	35	2	PS50929
Domain	ABC1_TM_dom	ABCD1 ABCD2	1.25e-03	28	35	2	IPR011527
Domain	Ig-like_fold	OBSCN KDR FGFR1 BTN2A1 SEMA3E BTN2A3P	1.82e-03	706	35	6	IPR013783
Domain	PRY	BTN2A1 BTN2A3P	3.65e-03	48	35	2	SM00589
Domain	PRY	BTN2A1 BTN2A3P	3.65e-03	48	35	2	IPR006574
Domain	CUB	CSMD1 CSMD3	3.80e-03	49	35	2	PF00431
Domain	CUB	CSMD1 CSMD3	3.95e-03	50	35	2	SM00042
Domain	Sushi	CSMD1 CSMD3	4.27e-03	52	35	2	PF00084
Domain	-	CSMD1 CSMD3	4.27e-03	52	35	2	2.60.120.290
Domain	CUB	CSMD1 CSMD3	4.43e-03	53	35	2	PS01180
Domain	CCP	CSMD1 CSMD3	4.59e-03	54	35	2	SM00032
Domain	V-set	KDR BTN2A1 BTN2A3P	4.88e-03	184	35	3	PF07686
Domain	SUSHI	CSMD1 CSMD3	4.93e-03	56	35	2	PS50923
Domain	Sushi_SCR_CCP_dom	CSMD1 CSMD3	5.10e-03	57	35	2	IPR000436
Domain	CUB_dom	CSMD1 CSMD3	5.10e-03	57	35	2	IPR000859
Domain	Ig_I-set	OBSCN KDR FGFR1	5.34e-03	190	35	3	IPR013098
Domain	I-set	OBSCN KDR FGFR1	5.34e-03	190	35	3	PF07679
Domain	-	OBSCN KDR FGFR1 BTN2A1 SEMA3E	7.46e-03	663	35	5	2.60.40.10
Domain	Butyrophylin	BTN2A1 BTN2A3P	7.61e-03	70	35	2	IPR003879
Domain	IQ	OBSCN MYO15A	7.82e-03	71	35	2	PF00612
Domain	IGc2	OBSCN KDR FGFR1	9.57e-03	235	35	3	SM00408
Pathway	KEGG_ABC_TRANSPORTERS	ABCD1 ABCA4 ABCD2	1.09e-04	44	30	3	M11911
Pathway	REACTOME_BUTYROPHILIN_BTN_FAMILY_INTERACTIONS	BTN2A1 BTN2A3P	1.56e-04	9	30	2	MM15487
Pathway	REACTOME_NEUTROPHIL_DEGRANULATION	MMP25 GLIPR1 CYSTM1 TCIRG1 ARSB ASAH1	4.37e-04	478	30	6	M27620
Pathway	REACTOME_ABC_TRANSPORTERS_IN_LIPID_HOMEOSTASIS	ABCD1 ABCD2	5.84e-04	17	30	2	MM14552
Pathway	REACTOME_NEUTROPHIL_DEGRANULATION	MMP25 GLIPR1 CYSTM1 TCIRG1 ARSB ASAH1	6.23e-04	511	30	6	MM15330
Pathway	REACTOME_ABC_TRANSPORTERS_IN_LIPID_HOMEOSTASIS	ABCD1 ABCD2	6.56e-04	18	30	2	M524
Pathway	REACTOME_CLASS_I_PEROXISOMAL_MEMBRANE_PROTEIN_IMPORT	ABCD1 ABCD2	7.32e-04	19	30	2	MM15651
Pathway	REACTOME_CLASS_I_PEROXISOMAL_MEMBRANE_PROTEIN_IMPORT	ABCD1 ABCD2	8.12e-04	20	30	2	M27930
Pathway	WP_KALLMANN_SYNDROME	FGFR1 SEMA3E	1.17e-03	24	30	2	M42530
Pathway	REACTOME_ABC_FAMILY_PROTEINS_MEDIATED_TRANSPORT	ABCD1 ABCA4 ABCD2	1.19e-03	99	30	3	MM14986
Pathway	KEGG_MEDICUS_REFERENCE_REGULATION_OF_GF_RTK_RAS_ERK_SIGNALING_UBIQUITINATION_OF_RTK_BY_CBL	KDR FGFR1	1.27e-03	25	30	2	M47934
Pathway	REACTOME_ABC_FAMILY_PROTEINS_MEDIATED_TRANSPORT	ABCD1 ABCA4 ABCD2	1.33e-03	103	30	3	M758
Pubmed	Endothelial-derived angiocrine signals induce and sustain regenerative lung alveolarization.	KDR FGFR1	1.16e-06	2	38	2	22036563
Pubmed	Valproic acid induces antioxidant effects in X-linked adrenoleukodystrophy.	ABCD1 ABCD2	1.16e-06	2	38	2	20179078
Pubmed	CRISPR/Cas9-mediated knockout of Abcd1 and Abcd2 genes in BV-2 cells: novel microglial models for X-linked Adrenoleukodystrophy.	ABCD1 ABCD2	1.16e-06	2	38	2	30769094
Pubmed	A key role for the peroxisomal ABCD2 transporter in fatty acid homeostasis.	ABCD1 ABCD2	1.16e-06	2	38	2	18854420
Pubmed	Peroxisomal ATP-binding cassette transporters form mainly tetramers.	ABCD1 ABCD2	1.16e-06	2	38	2	28258215
Pubmed	Targeted Brain Delivery of Dendrimer-4-Phenylbutyrate Ameliorates Neurological Deficits in a Long-Term ABCD1-Deficient Mouse Model of X-Linked Adrenoleukodystrophy.	ABCD1 ABCD2	1.16e-06	2	38	2	36207570
Pubmed	Structure-function analysis of peroxisomal ATP-binding cassette transporters using chimeric dimers.	ABCD1 ABCD2	1.16e-06	2	38	2	25043761
Pubmed	Abcd2 is a strong modifier of the metabolic impairments in peritoneal macrophages of ABCD1-deficient mice.	ABCD1 ABCD2	1.16e-06	2	38	2	25255441
Pubmed	ATP-binding and -hydrolysis activities of ALDP (ABCD1) and ALDRP (ABCD2), human peroxisomal ABC proteins, overexpressed in Sf21 cells.	ABCD1 ABCD2	1.16e-06	2	38	2	16946495
Pubmed	Functional overlap between ABCD1 (ALD) and ABCD2 (ALDR) transporters: a therapeutic target for X-adrenoleukodystrophy.	ABCD1 ABCD2	1.16e-06	2	38	2	15489218
Pubmed	Differential substrate specificities of human ABCD1 and ABCD2 in peroxisomal fatty acid β-oxidation.	ABCD1 ABCD2	1.16e-06	2	38	2	21145416
Pubmed	Fibroblast Growth Factor Receptor 1 (FGFR1), Partly Related to Vascular Endothelial Growth Factor Receptor 2 (VEGFR2) and Microvessel Density, is an Independent Prognostic Factor for Non-Small Cell Lung Cancer.	KDR FGFR1	1.16e-06	2	38	2	28088809
Pubmed	Deregulation of Flk-1/vascular endothelial growth factor receptor-2 in fibroblast growth factor receptor-1-deficient vascular stem cell development.	KDR FGFR1	1.16e-06	2	38	2	15020678
Pubmed	The role of peroxisomal ABC transporters in the mouse adrenal gland: the loss of Abcd2 (ALDR), Not Abcd1 (ALD), causes oxidative damage.	ABCD1 ABCD2	1.16e-06	2	38	2	17260006
Pubmed	Silencing of Abcd1 and Abcd2 genes sensitizes astrocytes for inflammation: implication for X-adrenoleukodystrophy.	ABCD1 ABCD2	1.16e-06	2	38	2	18723473
Pubmed	Adrenoleukodystrophy-related protein can compensate functionally for adrenoleukodystrophy protein deficiency (X-ALD): implications for therapy.	ABCD1 ABCD2	1.16e-06	2	38	2	10196381
Pubmed	Identification of two new members of the CSMD gene family.	CSMD1 CSMD3	3.48e-06	3	38	2	12906867
Pubmed	Butyrophilin 2a2 (Btn2a2) expression on thymic epithelial cells promotes central T cell tolerance and prevents autoimmune disease.	BTN2A1 BTN2A3P	3.48e-06	3	38	2	37356345
Pubmed	Live cell FRET microscopy: homo- and heterodimerization of two human peroxisomal ABC transporters, the adrenoleukodystrophy protein (ALDP, ABCD1) and PMP70 (ABCD3).	ABCD1 ABCD2	3.48e-06	3	38	2	17609205
Pubmed	Homo- and heterodimerization of peroxisomal ATP-binding cassette half-transporters.	ABCD1 ABCD2	3.48e-06	3	38	2	10551832
Pubmed	Activation of sirtuin 1 as therapy for the peroxisomal disease adrenoleukodystrophy.	ABCD1 ABCD2	3.48e-06	3	38	2	25822341
Pubmed	RANKL-Induced Btn2a2 - A T Cell Immunomodulatory Molecule - During Osteoclast Differentiation Fine-Tunes Bone Resorption.	BTN2A1 BTN2A3P	3.48e-06	3	38	2	34421818
Pubmed	Characterization of human ATP-binding cassette protein subfamily D reconstituted into proteoliposomes.	ABCD1 ABCD2	3.48e-06	3	38	2	29397936
Pubmed	Impaired tumor growth and angiogenesis in mice heterozygous for Vegfr2 (Flk1).	KDR FGFR1	3.48e-06	3	38	2	30283071
Pubmed	Anlotinib inhibits angiogenesis via suppressing the activation of VEGFR2, PDGFRβ and FGFR1.	KDR FGFR1	3.48e-06	3	38	2	29454091
Pubmed	The antiangiogenic activity in xenograft models of brivanib, a dual inhibitor of vascular endothelial growth factor receptor-2 and fibroblast growth factor receptor-1 kinases.	KDR FGFR1	3.48e-06	3	38	2	20103604
Pubmed	Peroxisomal ABC Transporters: An Update.	ABCD1 ABCD2	3.48e-06	3	38	2	34198763
Pubmed	Integration of repulsive guidance cues generates avascular zones that shape mammalian blood vessels.	KDR FGFR1 SEMA3E	5.30e-06	31	38	3	22076636
Pubmed	Integrin activation is required for VEGF and FGF receptor protein presence on human microvascular endothelial cells.	KDR FGFR1	6.96e-06	4	38	2	11693202
Pubmed	Btn2a2 Regulates ILC2-T Cell Cross Talk in Type 2 Immune Responses.	BTN2A1 BTN2A3P	6.96e-06	4	38	2	35145516
Pubmed	Identification of novel SNPs of ABCD1, ABCD2, ABCD3, and ABCD4 genes in patients with X-linked adrenoleukodystrophy (ALD) based on comprehensive resequencing and association studies with ALD phenotypes.	ABCD1 ABCD2	6.96e-06	4	38	2	20661612
Pubmed	ABC Transporter Subfamily D: Distinct Differences in Behavior between ABCD1-3 and ABCD4 in Subcellular Localization, Function, and Human Disease.	ABCD1 ABCD2	6.96e-06	4	38	2	27766264
Pubmed	Aberrant regulation of the GSK-3β/NRF2 axis unveils a novel therapy for adrenoleukodystrophy.	ABCD1 ABCD2	6.96e-06	4	38	2	29997171
Pubmed	Butyrophilin Btn2a2 inhibits TCR activation and phosphatidylinositol 3-kinase/Akt pathway signaling and induces Foxp3 expression in T lymphocytes.	BTN2A1 BTN2A3P	6.96e-06	4	38	2	23589618
Pubmed	Id1 modulates endothelial progenitor cells function through relieving the E2-2-mediated repression of FGFR1 and VEGFR2 in vitro.	KDR FGFR1	6.96e-06	4	38	2	26476925
Pubmed	Btn2a2, a T cell immunomodulatory molecule coregulated with MHC class II genes.	BTN2A1 BTN2A3P	6.96e-06	4	38	2	26809444
Pubmed	Human adrenoleukodystrophy protein and related peroxisomal ABC transporters interact with the peroxisomal assembly protein PEX19p.	ABCD1 ABCD2	6.96e-06	4	38	2	10777694
Pubmed	Two splice variants of human PEX19 exhibit distinct functions in peroxisomal assembly.	ABCD1 ABCD2	1.16e-05	5	38	2	11883941
Pubmed	Neuropilin 1 expression correlates with differentiation status of epidermal cells and cutaneous squamous cell carcinomas.	KDR SEMA3E	1.16e-05	5	38	2	24791743
Pubmed	FGF-dependent regulation of VEGF receptor 2 expression in mice.	KDR FGFR1	1.16e-05	5	38	2	21633168
Pubmed	MicroRNA-16 and microRNA-424 regulate cell-autonomous angiogenic functions in endothelial cells via targeting vascular endothelial growth factor receptor-2 and fibroblast growth factor receptor-1.	KDR FGFR1	1.16e-05	5	38	2	21885851
Pubmed	Sema3E-PlexinD1 signaling selectively suppresses disoriented angiogenesis in ischemic retinopathy in mice.	KDR SEMA3E	1.16e-05	5	38	2	21505259
Pubmed	BTN1A1, the mammary gland butyrophilin, and BTN2A2 are both inhibitors of T cell activation.	BTN2A1 BTN2A3P	1.74e-05	6	38	2	20208008
Pubmed	The four murine peroxisomal ABC-transporter genes differ in constitutive, inducible and developmental expression.	ABCD1 ABCD2	2.43e-05	7	38	2	10504404
Pubmed	Inactivation of the peroxisomal ABCD2 transporter in the mouse leads to late-onset ataxia involving mitochondria, Golgi and endoplasmic reticulum damage.	ABCD1 ABCD2	2.43e-05	7	38	2	16223892
Pubmed	Dysfunctional SEMA3E signaling underlies gonadotropin-releasing hormone neuron deficiency in Kallmann syndrome.	KDR SEMA3E	2.43e-05	7	38	2	25985275
Pubmed	The cluster of BTN genes in the extended major histocompatibility complex.	BTN2A1 BTN2A3P	2.43e-05	7	38	2	11170752
Pubmed	VEGFR2 (KDR/Flk1) signaling mediates axon growth in response to semaphorin 3E in the developing brain.	KDR SEMA3E	2.43e-05	7	38	2	20434998
Pubmed	fgfr-1 is required for embryonic growth and mesodermal patterning during mouse gastrulation.	KDR FGFR1	2.43e-05	7	38	2	8001822
Pubmed	Semaphorin-4A, an activator for T-cell-mediated immunity, suppresses angiogenesis via Plexin-D1.	KDR SEMA3E	2.43e-05	7	38	2	17318185
Pubmed	FGF9 and SHH regulate mesenchymal Vegfa expression and development of the pulmonary capillary network.	KDR FGFR1	3.24e-05	8	38	2	17881491
Pubmed	Brachyury drives formation of a distinct vascular branchpoint critical for fetal-placental arterial union in the mouse gastrula.	KDR FGFR1	3.24e-05	8	38	2	28389228
Pubmed	VEGF mediates commissural axon chemoattraction through its receptor Flk1.	KDR SEMA3E	3.24e-05	8	38	2	21658588
Pubmed	Microtubule-associated protein 6 mediates neuronal connectivity through Semaphorin 3E-dependent signalling for axonal growth.	KDR SEMA3E	3.24e-05	8	38	2	26037503
Pubmed	The diminished expression of proangiogenic growth factors and their receptors in gastric ulcers of cirrhotic patients.	KDR FGFR1	4.16e-05	9	38	2	23620752
Pubmed	Isolation of tyrosine kinase related genes expressed in the early hematopoietic system.	KDR FGFR1	5.20e-05	10	38	2	8034026
Pubmed	Establishment of neurovascular congruency in the mouse whisker system by an independent patterning mechanism.	KDR SEMA3E	6.35e-05	11	38	2	24139045
Pubmed	Loss of late primitive streak mesoderm and interruption of left-right morphogenesis in the Ednrb(s-1Acrg) mutant mouse.	KDR FGFR1	7.62e-05	12	38	2	10964471
Pubmed	Endothelial cell FGF signaling is required for injury response but not for vascular homeostasis.	KDR FGFR1	9.00e-05	13	38	2	25139991
Pubmed	PEX19 binds multiple peroxisomal membrane proteins, is predominantly cytoplasmic, and is required for peroxisome membrane synthesis.	ABCD1 ABCD2	1.38e-04	16	38	2	10704444
Pubmed	Fibroblast growth factor signals regulate a wave of Hedgehog activation that is essential for coronary vascular development.	KDR FGFR1	1.56e-04	17	38	2	16778080
Pubmed	Control of TurboID-dependent biotinylation intensity in proximity ligation screens.	ABCD1 ARSB SEC16A	1.81e-04	100	38	3	36966971
Pubmed	Pathfinding of corticothalamic axons relies on a rendezvous with thalamic projections.	KDR SEMA3E	1.96e-04	19	38	2	23395374
Pubmed	Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.	PRORP SEMA3E SEC16A	2.03e-04	104	38	3	9205841
Pubmed	VEGF signaling through neuropilin 1 guides commissural axon crossing at the optic chiasm.	KDR SEMA3E	2.18e-04	20	38	2	21658587
Pubmed	Discovery and characterization of spontaneous mouse models of craniofacial dysmorphology.	FGFR1 ARSB	2.41e-04	21	38	2	26234751
Pubmed	FGF9 regulates early hypertrophic chondrocyte differentiation and skeletal vascularization in the developing stylopod.	KDR FGFR1	2.65e-04	22	38	2	17544391
Pubmed	Fgf9 signalling stimulates Spred and Sprouty expression in embryonic mouse pancreas mesenchyme.	KDR FGFR1	2.90e-04	23	38	2	20934536
Pubmed	Loss of semaphorin-neuropilin-1 signaling causes dysmorphic vascularization reminiscent of alveolar capillary dysplasia.	KDR SEMA3E	3.16e-04	24	38	2	23063659
Pubmed	Vegf regulates embryonic erythroid development through Gata1 modulation.	KDR FGFR1	3.16e-04	24	38	2	20554972
Pubmed	Identification of tyrosine kinases expressed in the male mouse gubernaculum during development.	KDR FGFR1	3.43e-04	25	38	2	15254900
Pubmed	Peroxisome Metabolism Contributes to PIEZO2-Mediated Mechanical Allodynia.	ABCD1 ABCD2	3.43e-04	25	38	2	35681537
Pubmed	Isolated Gonadotropin-Releasing Hormone (GnRH) Deficiency	FGFR1 SEMA3E	4.32e-04	28	38	2	20301509
Pubmed	Novel splice variants derived from the receptor tyrosine kinase superfamily are potential therapeutics for rheumatoid arthritis.	KDR FGFR1	4.32e-04	28	38	2	18593464
Pubmed	Murine txk: a protein tyrosine kinase gene regulated by T cell activation.	KDR FGFR1	5.65e-04	32	38	2	7542761
Pubmed	Genome-wide association study of selenium concentrations.	ARSB CSMD1	6.76e-04	35	38	2	25343990
Pubmed	Genetic variants in COL2A1, COL11A2, and IRF6 contribute risk to nonsyndromic cleft palate.	MMP25 FGFR1	7.15e-04	36	38	2	20672350
Pubmed	TGFβ attenuates cartilage extracellular matrix degradation via enhancing FBXO6-mediated MMP14 ubiquitination.	ABCD1 ASAH1 STT3B	7.69e-04	164	38	3	32409323
Pubmed	High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men.	TCIRG1 KDR FGFR1 CRHR2	7.95e-04	383	38	4	19453261
Pubmed	USP7 represses lineage differentiation genes in mouse embryonic stem cells by both catalytic and noncatalytic activities.	KATNAL2 ABCD1 BTN2A1 BTN2A3P CNTNAP2	7.96e-04	674	38	5	37196079
Pubmed	Impact of Fgf10 deficiency on pulmonary vasculature formation in a mouse model of bronchopulmonary dysplasia.	KDR FGFR1	8.40e-04	39	38	2	30566624
Pubmed	Replication of previous genome-wide association studies of bone mineral density in premenopausal American women.	CSMD1 CNTNAP2	1.07e-03	44	38	2	20200978
GeneFamily	ATP binding cassette subfamily D	ABCD1 ABCD2	1.29e-05	4	27	2	808
GeneFamily	Butyrophilins\|V-set domain containing\|C2-set domain containing	BTN2A1 BTN2A3P	2.23e-04	15	27	2	458
GeneFamily	Receptor Tyrosine Kinases\|CD molecules	KDR FGFR1	1.62e-03	40	27	2	321
GeneFamily	Blood group antigens\|CD molecules\|I-set domain containing\|Immunoglobulin like domain containing	OBSCN KDR FGFR1	1.73e-03	161	27	3	593
GeneFamily	Immunoglobulin heavy locus at 14q32.33	IGHV4-61 IGHV4-30-4 IGHV4-30-2	2.65e-03	187	27	3	349
GeneFamily	Hyalectan proteoglycans\|V-set domain containing\|Sushi domain containing\|C-type lectin domain containing	CSMD1 CSMD3	3.26e-03	57	27	2	1179
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	OBSCN ABCA4 CSMD1 MYO15A CSMD3	4.25e-07	184	37	5	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	OBSCN ABCA4 CSMD1 MYO15A CSMD3	4.25e-07	184	37	5	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	OBSCN ABCA4 CSMD1 MYO15A CSMD3	4.25e-07	184	37	5	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	COVID-19-kidney-Technical/muscle_(PCT)\|kidney / Disease (COVID-19 only), tissue and cell type	CSMD1 KDM4E CSMD3 CNTNAP2	6.47e-06	146	37	4	c55f1bdb6ac43b4118cb27ea7c879527e1afcbab
ToppCell	Smart-seq2-blood_(Smart-seq2)-myeloid-myeloid_granulocytic-neutrophil\|blood_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	MMP25 CSMD1 CSMD3 SEMA3E	7.01e-06	149	37	4	c5eedb54ef2e0f131aa6730612c921bc19479632
ToppCell	Smart-seq2-blood_(Smart-seq2)-myeloid-myeloid_granulocytic\|blood_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	MMP25 CSMD1 CSMD3 SEMA3E	7.01e-06	149	37	4	a22417286de8606f0cc94f86b70bce17aeefb9c2
ToppCell	droplet-Spleen-nan-18m-Myeloid-macrophage_dendritic_cell_progenitor\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	OBSCN KDR FGFR1 ASAH1	1.21e-05	171	37	4	4e856441063e9825b6f87a1d3dd19c77dae4662c
ToppCell	HSPCs-Mono_prog.\|HSPCs / Lineage and Cell class	GLIPR1 TCIRG1 ABCD2 ASAH1	1.51e-05	181	37	4	a188f0d22426d8723ba394d94d20431afa6722a7
ToppCell	PND10-Epithelial\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CLIP4 CYSTM1 SLC6A14 SEMA3E	1.79e-05	189	37	4	89349e226a5512833a94b1bf68056a6985fe4afd
ToppCell	PND03-Epithelial\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CLIP4 CYSTM1 SLC6A14 SEMA3E	1.90e-05	192	37	4	d8c23693f690d4d568585537bbfedda05d505b3d
ToppCell	Epithelial\|World / shred on cell class and cell subclass (v4)	CLIP4 CYSTM1 SLC6A14 SEMA3E	1.90e-05	192	37	4	13a3553d9a7c78535679d23d454c63fd08f7d218
ToppCell	E18.5-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT1-AT1_mature\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CYSTM1 ASAH1 SLC6A14 SEMA3E	1.98e-05	194	37	4	ad3eb98f94a007c5988ede06238255f5b03bee6e
ToppCell	E18.5-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT1\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CYSTM1 ASAH1 SLC6A14 SEMA3E	1.98e-05	194	37	4	a281ebab117589fc922ead0a712cfe0a844c94ac
ToppCell	(3)_Chondrocytes-(30)_Chondro\|(3)_Chondrocytes / Cell class and subclass of bone marrow stroma cells in homeostatis	CLIP4 CYSTM1 KDR FGFR1	2.02e-05	195	37	4	f5597d3ed37770c6fa2b339f98a80ac7ecd4f9ff
ToppCell	Epithelial-A_(AT1)\|World / shred on cell class and cell subclass (v4)	CYSTM1 ASAH1 SLC6A14 SEMA3E	2.06e-05	196	37	4	484bbc6b1f58bc260964babb949d14f5df101393
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-OPC-OPC-F\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	FGFR1 CSMD1 CSMD3 CNTNAP2	2.23e-05	200	37	4	ad777683adeb2ce45ade570386235e311fa7ea2d
ToppCell	Entopeduncular-Endothelial-ENDOTHELIAL_STALK-Flt1_2-Endothelial_Stalk.Flt1.Tgfb2_(Tgfb2)--\|Entopeduncular / BrainAtlas - Mouse McCarroll V32	OBSCN MMP25 MYO15A	4.66e-05	84	37	3	43e77117579290446a7e386c0be3459d652d9384
ToppCell	Entopeduncular-Endothelial-ENDOTHELIAL_STALK-Flt1_2-Endothelial_Stalk.Flt1.Tgfb2_(Tgfb2)\|Entopeduncular / BrainAtlas - Mouse McCarroll V32	OBSCN MMP25 MYO15A	4.66e-05	84	37	3	38a457a20701fe23c6326b7282cd0993cdd87082
ToppCell	Entopeduncular-Endothelial-ENDOTHELIAL_STALK-Flt1_2-Endothelial_Stalk.Flt1.Tgfb2_(Tgfb2)-\|Entopeduncular / BrainAtlas - Mouse McCarroll V32	OBSCN MMP25 MYO15A	4.66e-05	84	37	3	59d0415bb6b6b18a94d2c9c6289fa9cbcb2166e3
ToppCell	COVID-19_Mild-Neu_3\|World / 5 Neutrophil clusters in COVID-19 patients	OBSCN CSMD1 CSMD3	1.41e-04	122	37	3	2aa9cfadab70312882ae679e3788fc7ab996c0f3
ToppCell	facs-Trachea-3m-Mesenchymal-fibroblast-fibroblast_of_trachea-\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CSMD1 MYO15A CHODL	1.67e-04	129	37	3	cbeeaa554da971ba2e4c4b82c85a1d070a45abb8
ToppCell	COVID-19-kidney-Mito-rich_Int\|kidney / Disease (COVID-19 only), tissue and cell type	CSMD1 CSMD3 CNTNAP2	1.67e-04	129	37	3	57b705106aec7bbfc587de1ccd4f2335fc44dd6f
ToppCell	E18.5-samps-Epithelial-Alveolar_epithelial-AT1_-_meso\|E18.5-samps / Age Group, Lineage, Cell class and subclass	CYSTM1 SLC6A14 SEMA3E	2.21e-04	142	37	3	77fd145c1c500d580f70ac4e54c3fd879ecf0ab3
ToppCell	COVID-19-kidney-Mito-rich_EC\|COVID-19 / Disease (COVID-19 only), tissue and cell type	KDR FGFR1 DIPK2B	2.35e-04	145	37	3	afed661aef990edb8e7012ab67ace56443520c9f
ToppCell	PND01-03-samps-Epithelial-Alveolar_epithelial-AT1_-_meso\|PND01-03-samps / Age Group, Lineage, Cell class and subclass	CYSTM1 SLC6A14 SEMA3E	2.60e-04	150	37	3	6a13e4c4b9c9e54a5016573a37132465ec1c8f99
ToppCell	Bronchial_Biopsy-Epithelial-Goblet_2\|Bronchial_Biopsy / Tissue, Lineage and Cell class of Lung Cells from 10X	KDR CHODL SLC6A14	2.75e-04	153	37	3	b25629953ff79aff645845376132b12023067b01
ToppCell	NS-critical-d_16-33-Myeloid-Monocyte-derived_Macrophage\|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	ABCD1 KDM4E CNTNAP2	2.75e-04	153	37	3	859de35b24c5d7d73be1c213b90b43362ee2e0eb
ToppCell	Bronchial_Biopsy-Epithelial-Goblet_2\|Epithelial / Tissue, Lineage and Cell class of Lung Cells from 10X	MMP25 KDR CHODL	2.75e-04	153	37	3	e9d6b4e895ddb8d6e6c8b043da591ec11365e124
ToppCell	E16.5-samps-Epithelial-Alveolar_epithelial_precursor-Noncycling_AT1_Precursor\|E16.5-samps / Age Group, Lineage, Cell class and subclass	CYSTM1 SLC6A14 SEMA3E	2.81e-04	154	37	3	8a643d91896af9b630a715fb284c1523d01ad1a3
ToppCell	primary_visual_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Rspo1_Itga4\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	CSMD3 CRHR2 CNTNAP2	2.86e-04	155	37	3	cba6f3f7742b4d5d54ad0a0ac0dd4016e73fe658
ToppCell	primary_visual_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Rspo4_Rxfp1_Chat\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	CSMD3 CRHR2 CNTNAP2	2.86e-04	155	37	3	3b8def9e8f66511736ea37f259511f7c8b7743af
ToppCell	PND03-Immune-Immune_Myeloid-DC-maDC\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	MMP25 GLIPR1 ARSB	2.91e-04	156	37	3	095281ea78aefa0ee638191a03f8d6f62a86a9ff
ToppCell	PND03-Immune-Immune_Myeloid-DC-maDC-maDC_mature\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	MMP25 GLIPR1 ARSB	2.91e-04	156	37	3	29b04143f71a0ecc600ac670abd1d521bee55fe7
ToppCell	COVID-19-kidney-Technical/muscle_(Mes)\|kidney / Disease (COVID-19 only), tissue and cell type	CSMD1 CSMD3 CNTNAP2	3.08e-04	159	37	3	5335cbcdeaf2bbd0268bbfe0e45c8c0d288e640d
ToppCell	COVID-19-kidney-Epithelial_(EC)\|kidney / Disease (COVID-19 only), tissue and cell type	KDR DIPK2B CNTNAP2	3.14e-04	160	37	3	0d4880f85565d8c540c94a8f8109147b3029279a
ToppCell	PND03-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT1/AT2-AT1/AT2_mature\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CLIP4 CYSTM1 SEMA3E	3.25e-04	162	37	3	d0d9c18a73bc0bf4f38308ef2eee8ae20f6a7918
ToppCell	PND03-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT1/AT2\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CLIP4 CYSTM1 SEMA3E	3.25e-04	162	37	3	06f5d6c0bb26fe9d5180bc2ebf2c54bf52e715f3
ToppCell	Brain_organoid-organoid_Velasco_nature-3_mon-Neuronal-Cajal-Retzius\|3_mon / Sample Type, Dataset, Time_group, and Cell type.	KDR SEMA3E CNTNAP2	3.25e-04	162	37	3	1f589a763f3fd4e1e612809ef3903879d47dc1d8
ToppCell	Brain_organoid-organoid_Paulsen_bioRxiv-3.5_mon-Neuronal-Cajal-Retzius\|3.5_mon / Sample Type, Dataset, Time_group, and Cell type.	KDR SEMA3E CNTNAP2	3.31e-04	163	37	3	c1484e4de8b10e2f5fb14a7c02b2a015ffe0305e
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Degenerative_Proximal_Tubule_Epithelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CSMD1 CSMD3 CNTNAP2	3.56e-04	167	37	3	3edb0570e583bb527165bcd8a4c25a042054043b
ToppCell	facs-Lung-3m-Epithelial-alveolar_epithelial-type_I_pneumocyte-type_1_alveolar_epithelial_cell\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CYSTM1 SLC6A14 SEMA3E	3.56e-04	167	37	3	9f2661729a2d58e17a9203a563d538c08a3dbbbc
ToppCell	droplet-Liver-LIVER_HEPATOCYTES-30m-Lymphocytic\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ABCA4 CSMD3 SEMA3E	3.56e-04	167	37	3	e1b1a952fce27ab9cf16919b290625ff4a75261e
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_C_(NP)-Glut_NP_L5/6_FEZF2\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	FGFR1 CRHR2 SEMA3E	3.56e-04	167	37	3	4e613be2b3ba01160b0c0254fce3c4f72220e580
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_C_(NP)-Glut_NP_L5/6_FEZF2-Exc_L5-6_FEZF2_MYBPHL\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	FGFR1 CRHR2 SEMA3E	3.56e-04	167	37	3	c7d1e84af1f4d7430858287520ac2cfa36203642
ToppCell	facs-Lung-3m-Epithelial-alveolar_epithelial-type_I_pneumocyte\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CYSTM1 SLC6A14 SEMA3E	3.56e-04	167	37	3	bebc2493a2ee41920b21c2b774a1c5a9619315c4
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_C_(NP)\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	FGFR1 CRHR2 SEMA3E	3.56e-04	167	37	3	18ad85751bd892309627eefc357eb28ec5a7c300
ToppCell	Adult-Endothelial-alveolar_capillary_endothelial_cell_(Cap2;_aerocyte)-D231\|Adult / Lineage, Cell type, age group and donor	OBSCN KDR DIPK2B	3.56e-04	167	37	3	5af9127bae05768a5164d5708a4ad37edca99324
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell__prolif\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	KDR FGFR1 DIPK2B	3.62e-04	168	37	3	37249f38f8f04ec5743097259de67b106ca2b02f
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_C_(NP)\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	FGFR1 CRHR2 SEMA3E	3.68e-04	169	37	3	bddb28a8b9afbe4a68f082e82caf96a6666fc674
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_C_(NP)-Glut_NP_L5/6_FEZF2\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	FGFR1 CRHR2 SEMA3E	3.68e-04	169	37	3	5ce46bac8e767feec7ecdc61689de225c49bd3f7
ToppCell	droplet-Lung-nan-18m-Myeloid-Myeloid_Dendritic_Type_2\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CYSTM1 FGFR1 ARSB	3.68e-04	169	37	3	149a4f83da15bdeb170e980fb5b5b1af89ae07a6
ToppCell	droplet-Spleen-nan-21m-Myeloid-macrophage_dendritic_cell_progenitor\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	OBSCN KDR FGFR1	3.68e-04	169	37	3	7962165cab84af73d20b56eb70b1ed87c94025ef
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_C_(NP)\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	FGFR1 CRHR2 SEMA3E	3.75e-04	170	37	3	ce2fd2fbbfd152290be0cf8e513f102fdc182b41
ToppCell	droplet-Lung-18m-Hematologic-myeloid-myeloid_dendritic_cell-dendritic_type_2\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CYSTM1 FGFR1 ARSB	3.75e-04	170	37	3	bf589c4297ccc90e5f51e3d0fcc229548af4fcef
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_C_(NP)-Glut_NP_L5/6_FEZF2\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	FGFR1 CRHR2 SEMA3E	3.75e-04	170	37	3	ab5c6a91c371e4df15b0842828dc55039695ab06
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_C_(NP)-Glut_NP_L5/6_FEZF2-Exc_L5-6_FEZF2_MYBPHL\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	FGFR1 CRHR2 SEMA3E	3.75e-04	170	37	3	4aa9e597f6550ac8cac3137a98be58e71efd07d6
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit-Glut_C_(NP)-Glut_NP_L5/6_FEZF2-Exc_L5-6_FEZF2_MYBPHL\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	FGFR1 CRHR2 SEMA3E	3.81e-04	171	37	3	0417fa805ca0acb7e9f6a30bc7b6bdbaba77844d
ToppCell	COVID-19-Heart-T_cell\|COVID-19 / Disease (COVID-19 only), tissue and cell type	CSMD1 CSMD3 CNTNAP2	3.81e-04	171	37	3	b2e753e811a7639956994609f73efcdb62d04f82
ToppCell	5'-Airway_Nasal-Immune_Lymphocytic-Lymphocytic_B-B_cell-B_cells\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	IGHV4-61 IGHV4-30-2 CNTNAP2	3.88e-04	172	37	3	172e3c78f8e97988a4fd8624514e731282ddc16d
ToppCell	5'-Airway_Nasal-Immune_Lymphocytic-Lymphocytic_B-B_cell-B_cells-B_cells_L.1.5.0.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	IGHV4-61 IGHV4-30-2 CNTNAP2	3.88e-04	172	37	3	5fb0ea6145892a258696197b3feed9760187e712
ToppCell	facs-Marrow-KLS-18m-Myeloid-promonocyte\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FGFR1 ARSB ASAH1	3.88e-04	172	37	3	979fd7b435f59b8a4d290a809cf76147d4c63d48
ToppCell	5'-Airway_Nasal-Immune_Lymphocytic-Lymphocytic_B-B_cell\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	IGHV4-61 IGHV4-30-2 CNTNAP2	3.88e-04	172	37	3	2214cc37d7c21b868768d3f74ca4631d339d37b3
ToppCell	5'-Airway_Nasal-Immune_Lymphocytic-Lymphocytic_B\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	IGHV4-61 IGHV4-30-2 CNTNAP2	3.88e-04	172	37	3	07620728a6cdeea805e1365e588be096c17a370c
ToppCell	facs-Marrow-KLS-18m-Myeloid-monocyte_+_promonocyte\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FGFR1 ARSB ASAH1	3.88e-04	172	37	3	f4d7f416802218ce56408fa4cb8a555d846bc85b
ToppCell	PND07-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT1/AT2\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CYSTM1 SLC6A14 SEMA3E	3.94e-04	173	37	3	45808cf69122c16b9d2b5ffa06d15392c55954b7
ToppCell	PND07-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT1/AT2-AT1/AT2_mature\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CYSTM1 SLC6A14 SEMA3E	3.94e-04	173	37	3	7fa9dbcb258c3ab974490063951620e2def03db1
ToppCell	3'-Child09-12-SmallIntestine-Mesenchymal-fibroblastic-Stromal_3_(C7+)\|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FGFR1 CHODL SEMA3E	3.94e-04	173	37	3	11e95a60b5f6f07f27154a23203bac431e7528c6
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT2_L6_FEZF2-Exc_L6_FEZF2_TBCC\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	FGFR1 CRHR2 SEMA3E	4.01e-04	174	37	3	912a9e892b29d945666fc37c986009c97c668ac8
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT2_L6_FEZF2-Exc_L6_FEZF2_TBCC\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	FGFR1 CRHR2 SEMA3E	4.01e-04	174	37	3	e0de0a14319be1a115e5be05d6f9b562e7b32c4a
ToppCell	droplet-Large_Intestine-COLON_PROXIMAL-30m-Epithelial-Enterocyte\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CYSTM1 SLC6A14 PNPO	4.01e-04	174	37	3	2fbdb62e269acf4447b171700a615e878dde7f9f
ToppCell	droplet-Large_Intestine-COLON_PROXIMAL-30m-Epithelial-enterocyte_of_epithelium_of_large_intestine\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CYSTM1 SLC6A14 PNPO	4.01e-04	174	37	3	7c52b5d8f1e65e5208c952be341fa155ed0e6e76
ToppCell	droplet-Spleen-nan-3m-Myeloid-macrophage_dendritic_cell_progenitor\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	OBSCN KDR ASAH1	4.08e-04	175	37	3	21bc0e59a9509d38751ce6aad2325f341bc70eff
ToppCell	PND14-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT1/AT2\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CYSTM1 SLC6A14 SEMA3E	4.08e-04	175	37	3	96219e58dcb327fd27190be78193e7a0d611e62b
ToppCell	facs-Marrow-B-cells-24m\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CSMD1 CSMD3 CNTNAP2	4.08e-04	175	37	3	887e75fc90e59a6394d62f3c048a9cfdf6707725
ToppCell	PND14-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT1/AT2-AT1/AT2_mature\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CYSTM1 SLC6A14 SEMA3E	4.08e-04	175	37	3	cb974fbebe8cb58c7d3f7defabb4e056f2fee5fa
ToppCell	P03-Epithelial-airway_epithelial_cell-ciliated_cell_of_airway\|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	CYSTM1 SLC6A14 SEMA3E	4.15e-04	176	37	3	f3a54038cde58326f1caed96ecca33c141bcc8b3
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2-Exc_L6_FEZF2_CPZ\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	FGFR1 SPEM2 SEMA3E	4.22e-04	177	37	3	57033ee0d49a4a50fc25328a4a44d4de2b35f505
ToppCell	PND28-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT1-AT1_mature\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CYSTM1 SLC6A14 SEMA3E	4.29e-04	178	37	3	a3af5d9c55858e36be0498081029ecb0acaeb3d3
ToppCell	PND28-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT1\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CYSTM1 SLC6A14 SEMA3E	4.29e-04	178	37	3	b3b88989bd602cfb55bb5c47731deb99288a8952
ToppCell	droplet-Bladder-BLADDER-1m-Endothelial-nan\|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KDR ABCD2 CRHR2	4.29e-04	178	37	3	6bef4ef48f649c6e38ae732bc08e6d7814db588b
ToppCell	P15-Epithelial\|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	CYSTM1 SLC6A14 SEMA3E	4.36e-04	179	37	3	869d3d203e2cb88636e2f0c4476c72571ae3b5ca
ToppCell	PCW_10-12-Endothelial-Endothelial_mature-lymphatic-endo_lymphatic_(7)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	KDR ABCA4 DIPK2B	4.36e-04	179	37	3	35fe9961e228ce255e3317fc244efa35b5adbf8b
ToppCell	PCW_10-12-Endothelial-Endothelial_mature-lymphatic\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	KDR ABCA4 DIPK2B	4.36e-04	179	37	3	ab3d08b51cd7a37582305615ee221c7a2af83b40
ToppCell	wk_08-11-Endothelial-Blood_vessel_endothelial-Venous_endo\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	KDR CHODL DIPK2B	4.36e-04	179	37	3	040a7e916baaf81f44339dc721ab2afcd2c22388
ToppCell	COVID-19-kidney-PLVAP+EC\|COVID-19 / Disease (COVID-19 only), tissue and cell type	KDR FGFR1 DIPK2B	4.43e-04	180	37	3	493cf8d1a8f2a1ed2672f394a0338b110fd81d88
ToppCell	PCW_05-06-Endothelial-Endothelial_mature-endo_arterial_(9)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	TCIRG1 KDR DIPK2B	4.43e-04	180	37	3	5861b44acfb8fe92c281c8355bf19c059b3dcd64
ToppCell	droplet-Heart-nan-3m-Neuronal-cardiac_neuron\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CYSTM1 SLC25A42 CSMD1	4.43e-04	180	37	3	da723df348d7b8449bb1124f23fe6fa706412adb
ToppCell	droplet-Heart-nan-3m-Neuronal\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CYSTM1 SLC25A42 CSMD1	4.43e-04	180	37	3	5b146a94708b3c3610542a4d0925f3f7a2b19185
ToppCell	droplet-Heart-nan-3m-Neuronal-cardiac_neuron\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CYSTM1 SLC25A42 CSMD1	4.43e-04	180	37	3	50758b1e7be2e43f83c10ab106900c067e61f5f7
ToppCell	HSPCs-Neutro_prog.\|HSPCs / Lineage and Cell class	TCIRG1 ARSB ABCD2	4.43e-04	180	37	3	328192f4678dcdc01c806362b225e770d23498d6
ToppCell	367C-Endothelial_cells-Endothelial-F_(Lymphatics)-\|367C / Donor, Lineage, Cell class and subclass (all cells)	KDR ABCA4 DIPK2B	4.50e-04	181	37	3	b244ecaa442bbef51289d8ec574ef08fa9e96318
ToppCell	P03-Epithelial\|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	CYSTM1 SLC6A14 SEMA3E	4.50e-04	181	37	3	de0466072f5b2ab8db3d9bab31e3205d1ff7cfb7
ToppCell	P03-Epithelial-alveolar_epithelial_cell\|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	CYSTM1 SLC6A14 SEMA3E	4.50e-04	181	37	3	c3dbf8850d3812fbb770798f4cf38908db8bb92b
ToppCell	P15-Epithelial-alveolar_epithelial_cell\|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	CYSTM1 SLC6A14 SEMA3E	4.50e-04	181	37	3	7033be0ba90556f7e5f7c0d4a9f7644afcb22c9b
ToppCell	367C-Endothelial_cells-Endothelial-F_(Lymphatics)\|367C / Donor, Lineage, Cell class and subclass (all cells)	KDR ABCA4 DIPK2B	4.50e-04	181	37	3	dd79de8098edb385a0f85d0e9621503cdf76ec43
ToppCell	PND14-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT1-AT1_mature\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CYSTM1 SLC6A14 SEMA3E	4.57e-04	182	37	3	573771130247e869e4e58f22d4a1cb31989635cf
ToppCell	PND14-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT1\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CYSTM1 SLC6A14 SEMA3E	4.57e-04	182	37	3	6cfaa2b3b3974c13b01c943f4adb70768dcc35e4
ToppCell	5'-Adult-Appendix-Endothelial-lymphatic_endothelial-LEC6_(ADAMTS4+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	KDR ABCA4 DIPK2B	4.57e-04	182	37	3	fd786c88826ad3d5cc5c3d80f8e392d6be1b5267
ToppCell	droplet-Heart-4Chambers-18m-Neuronal-cardiac_neuron\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC25A42 CSMD1 SEMA3E	4.57e-04	182	37	3	6fdaf3c8c3952a8f14dd7288e523ed58eb1d3517
ToppCell	facs-Trachea-24m-Epithelial-glandular_epithelial\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CLIP4 CYSTM1 SLC6A14	4.72e-04	184	37	3	61caaa31975e05c9a6512079c791fed5a9e2d39f
Drug	5-isopropyl-6-(5-methyl-1,3,4-oxadiazol-2-yl)-N-(2-methyl-1H-pyrrolo(2,3-b)pyridin-5-yl)pyrrolo(2,1-f)(1,2,4)triazin-4-amine	KDR FGFR1	2.30e-06	2	35	2	ctd:C529910
Disease	adrenoleukodystrophy (implicated_via_orthology)	ABCD1 ABCD2	3.03e-05	7	36	2	DOID:10588 (implicated_via_orthology)
Disease	Idiopathic hypogonadotropic hypogonadism	FGFR1 SEMA3E	2.19e-04	18	36	2	C0342384
Disease	response to TNF antagonist, joint damage measurement	PRORP CSMD3	4.27e-04	25	36	2	EFO_0004653, EFO_0005413
Disease	macular degeneration (is_implicated_in)	KDR ABCA4	4.98e-04	27	36	2	DOID:4448 (is_implicated_in)
Disease	age-related hearing impairment	CSMD1 CSMD3 SLC6A14 CNTNAP2	6.37e-04	324	36	4	EFO_0005782
Disease	Schizophrenia	KDR FGFR1 CSMD1 ASAH1 PNPO CNTNAP2	6.38e-04	883	36	6	C0036341
Disease	uridine measurement	ABCA4 CSMD1	7.01e-04	32	36	2	EFO_0010546
Disease	rheumatic heart disease	CHODL IGHV4-61	7.46e-04	33	36	2	EFO_1001161
Disease	Cleft upper lip	FGFR1 ABCA4	1.04e-03	39	36	2	C0008924
Disease	colitis (biomarker_via_orthology)	KDR CRHR2	1.21e-03	42	36	2	DOID:0060180 (biomarker_via_orthology)

Protein segments in the cluster

Peptide	Gene	Start	Entry
GGWYPKPLTVWRDPY	BTN2A3P	166	Q96KV6
SGVILPPGWPGYYKD	CSMD1	766	Q96PZ7
PPGWPGYYKDSLHCE	CSMD1	771	Q96PZ7
APSGVILSPGWPGYY	CSMD3	901	Q7Z407
FPGDYGTPLPWYFLL	ABCA4	861	P78363
GLWPVYEGVLYKPPP	ABCD2	526	Q9UBJ2
PKPYCQALPYGPGYW	FBXO34	651	Q9NWN3
YPPSGPTYRGAVPWY	ASAH1	36	Q13510
PGYWYGIELEKPHGK	CLIP4	511	Q8N3C7
FPGAEGWPLPKYLGS	DIPK2B	226	Q9H7Y0
AGPAVVPPQYYGVPW	PUM2	336	Q8TB72
VPPQYYGVPWGVYPA	PUM2	341	Q8TB72
GGLWPTYGGVLYKPP	ABCD1	521	P33897
LGVDWLTRYGYLPPP	MMP25	31	Q9NPA2
GPGGNYPTWPYKRGA	GLIPR1	176	P48060
LAGLGPYSPAWPPYG	MYO15A	261	Q9UKN7
PPGKGLEWIGYIYHS	IGHV4-30-2	61	A0A087WSY4
PPGKGLEWIGYIYYS	IGHV4-30-4	61	P0DP06
PPGKGLEWIGYIYYS	IGHV4-61	61	A0A0C4DH41
PWKGLLLYGPPGTGK	KATNAL2	286	Q8IYT4
GWGPPLDPEGPYSYC	CRHR2	26	Q13324
RYWKSHPGNPPIYGA	KDM4E	121	B2RXH2
PKPKSWGGYVLYPQV	PNPO	201	Q9NVS9
GYPAPRLYWFKDGQP	OBSCN	5286	Q5VST9
WEIFTLGGSPYPGVP	FGFR1	691	P11362
YPQYGWQGGPQEPPK	CYSTM1	46	Q9H1C7
YPKPLTVWRDPYGGV	BTN2A1	171	Q7KYR7
LTGYPGCGYWFPPPS	ARSB	441	P15848
YYWIDPDGSGPLGPL	CNTNAP2	611	Q9UHC6
VLYGGYLWMGYPPPA	C3orf56	81	Q8N813
YYGFRGEALPPWPRL	SLC25A42	121	Q86VD7
FPKLWKSPYLGLGPG	PRORP	11	O15091
PTANPGLGGPYLYQW	CHODL	151	Q9H9P2
PGFPEYGYPADTVWP	SEC16A	1416	O15027
LPFPYPKYPRRGWGG	SPEM2	191	Q0P670
WYPLGRIVGGTVYPG	STT3B	131	Q8TCJ2
HWSVYEGKVPYPRPG	SEMA3E	366	O15041
PAKYLGYPPPEIKWY	KDR	351	P35968
GYPPPEIKWYKNGIP	KDR	356	P35968
PNYGAIPYPDWGVAL	SLC6A14	551	Q9UN76
GVFLGPYPFGIDPIW	TCIRG1	506	Q13488
GSAPYYQPGSVWGPL	TMEM198	136	Q66K66