Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionhistone binding

UIMC1 SRCAP TBL1XR1 TBL1Y TBL1X

4.31e-05265305GO:0042393
GeneOntologyMolecularFunctiontranscription corepressor activity

PARP14 TBL1XR1 TBL1Y TBL1X

3.65e-04229304GO:0003714
GeneOntologyMolecularFunctionubiquitin-modified protein reader activity

UIMC1 IDE

4.08e-0420302GO:0140036
GeneOntologyMolecularFunctionubiquitin-like protein reader activity

UIMC1 IDE

6.41e-0425302GO:0140035
GeneOntologyMolecularFunctionprotein-macromolecule adaptor activity

UIMC1 IDE SRCAP PARP14 TBL1XR1 TBL1Y TBL1X

1.37e-031160307GO:0030674
GeneOntologyMolecularFunctiontranscription coregulator activity

SRCAP PARP14 TBL1XR1 TBL1Y TBL1X

1.38e-03562305GO:0003712
GeneOntologyCellularComponenthistone deacetylase complex

SRCAP TBL1XR1 TBL1Y TBL1X

4.16e-0685274GO:0000118
GeneOntologyCellularComponenttranscription repressor complex

TBL1XR1 TBL1Y TBL1X

1.89e-0487273GO:0017053
HumanPhenoCongenital hypoparathyroidism

GCM2 TBCE

1.52e-053122HP:0008198
DomainLisH

TBL1XR1 TBL1Y TBL1X

3.12e-079303PF08513
DomainLisH

TBL1XR1 TBL1Y TBL1X

1.19e-0528303IPR006594
DomainLisH

TBL1XR1 TBL1Y TBL1X

1.19e-0528303SM00667
DomainLISH

TBL1XR1 TBL1Y TBL1X

1.19e-0528303PS50896
Domain-

SEMA3A TBL1XR1 TBL1Y IFT172 TBL1X

1.73e-043333052.130.10.10
DomainWD40/YVTN_repeat-like_dom

SEMA3A TBL1XR1 TBL1Y IFT172 TBL1X

1.78e-04335305IPR015943
DomainG-protein_beta_WD-40_rep

TBL1XR1 TBL1Y TBL1X

3.38e-0485303IPR020472
DomainWD40

TBL1XR1 TBL1Y IFT172 TBL1X

7.46e-04259304PF00400
DomainWD40

TBL1XR1 TBL1Y IFT172 TBL1X

8.47e-04268304SM00320
DomainWD40_repeat

TBL1XR1 TBL1Y IFT172 TBL1X

8.95e-04272304IPR001680
DomainWD_REPEATS_1

TBL1XR1 TBL1Y IFT172 TBL1X

9.70e-04278304PS00678
DomainWD_REPEATS_2

TBL1XR1 TBL1Y IFT172 TBL1X

9.83e-04279304PS50082
DomainWD_REPEATS_REGION

TBL1XR1 TBL1Y IFT172 TBL1X

9.83e-04279304PS50294
DomainWD40_repeat_dom

TBL1XR1 TBL1Y IFT172 TBL1X

1.24e-03297304IPR017986
DomainWD40_repeat_CS

TBL1XR1 TBL1Y TBL1X

2.27e-03164303IPR019775
DomainHelicase_C

DDX60L SRCAP

1.27e-02107302PF00271
DomainHELICc

DDX60L SRCAP

1.27e-02107302SM00490
DomainHelicase_C

DDX60L SRCAP

1.30e-02108302IPR001650
DomainHELICASE_CTER

DDX60L SRCAP

1.32e-02109302PS51194
DomainHELICASE_ATP_BIND_1

DDX60L SRCAP

1.32e-02109302PS51192
DomainDEXDc

DDX60L SRCAP

1.32e-02109302SM00487
DomainHelicase_ATP-bd

DDX60L SRCAP

1.34e-02110302IPR014001
PathwayREACTOME_NR1H2_AND_NR1H3_MEDIATED_SIGNALING

TBL1XR1 TBL1Y TBL1X

1.23e-0613243MM15622
PathwayREACTOME_REGULATION_OF_LIPID_METABOLISM_BY_PPARALPHA

TBL1XR1 TBL1Y TBL1X

3.48e-0618243MM15034
PathwayREACTOME_NOTCH_HLH_TRANSCRIPTION_PATHWAY

TBL1XR1 TBL1Y TBL1X

7.51e-0623243MM14954
PathwayREACTOME_LOSS_OF_MECP2_BINDING_ABILITY_TO_THE_NCOR_SMRT_COMPLEX

TBL1XR1 TBL1X

5.80e-057242M27899
PathwayREACTOME_CYTOPROTECTION_BY_HMOX1

TBL1XR1 TBL1Y TBL1X

9.07e-0552243MM15684
PathwayREACTOME_HDACS_DEACETYLATE_HISTONES

TBL1XR1 TBL1Y TBL1X

1.07e-0455243MM14932
PathwayREACTOME_LOSS_OF_FUNCTION_OF_MECP2_IN_RETT_SYNDROME

TBL1XR1 TBL1X

2.14e-0413242M29766
PathwayREACTOME_SIGNALING_BY_NUCLEAR_RECEPTORS

TBL1XR1 TBL1Y POLR2C TBL1X

2.81e-04191244MM15586
PathwayREACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION

ZNF638 TBL1XR1 TBL1X

3.77e-0484243M1008
PathwayREACTOME_RORA_ACTIVATES_GENE_EXPRESSION

TBL1XR1 TBL1X

4.18e-0418242M26942
PathwayREACTOME_SIGNALING_BY_FGFR2_IIIA_TM

FGF1 POLR2C

4.67e-0419242M27739
PathwayREACTOME_ADIPOGENESIS

ZNF638 TBL1XR1 TBL1X

8.30e-04110243M48259
PathwayREACTOME_BMAL1_CLOCK_NPAS2_ACTIVATES_CIRCADIAN_GENE_EXPRESSION

TBL1XR1 TBL1X

9.50e-0427242M26943
PathwayREACTOME_NOTCH_HLH_TRANSCRIPTION_PATHWAY

TBL1XR1 TBL1X

1.02e-0328242M6177
PathwayREACTOME_REGULATION_OF_MECP2_EXPRESSION_AND_ACTIVITY

TBL1XR1 TBL1X

1.34e-0332242M27900
PathwayREACTOME_FGFR2_MUTANT_RECEPTOR_ACTIVATION

FGF1 POLR2C

1.42e-0333242M27049
PathwayREACTOME_NR1H3_NR1H2_REGULATE_GENE_EXPRESSION_LINKED_TO_CHOLESTEROL_TRANSPORT_AND_EFFLUX

TBL1XR1 TBL1X

1.78e-0337242M29790
Pubmed

Hepatic deficiency in transcriptional cofactor TBL1 promotes liver steatosis and hypertriglyceridemia.

TBL1XR1 TBL1Y TBL1X

5.78e-09530321459324
Pubmed

Structure of the MeCP2-TBLR1 complex reveals a molecular basis for Rett syndrome and related disorders.

TBL1XR1 TBL1Y TBL1X

1.16e-08630328348241
Pubmed

Zbtb7c is a molecular 'off' and 'on' switch of Mmp gene transcription.

TBL1XR1 TBL1Y TBL1X

2.02e-08730327646874
Pubmed

The nuclear receptor corepressor deacetylase activating domain is essential for repression by thyroid hormone receptor.

TBL1XR1 TBL1Y TBL1X

2.02e-08730315695367
Pubmed

A SUMOylation-dependent pathway mediates transrepression of inflammatory response genes by PPAR-gamma.

TBL1XR1 TBL1Y TBL1X

3.23e-08830316127449
Pubmed

Rett syndrome mutations abolish the interaction of MeCP2 with the NCoR/SMRT co-repressor.

TBL1XR1 TBL1Y TBL1X

3.23e-08830323770565
Pubmed

A corepressor/coactivator exchange complex required for transcriptional activation by nuclear receptors and other regulated transcription factors.

TBL1XR1 TBL1Y TBL1X

6.92e-081030314980219
Pubmed

SUMOylation of TBL1 and TBLR1 promotes androgen-independent prostate cancer cell growth.

TBL1XR1 TBL1X

7.19e-07230227129164
Pubmed

X-linked late-onset sensorineural deafness caused by a deletion involving OA1 and a novel gene containing WD-40 repeats.

TBL1Y TBL1X

7.19e-07230210330347
Pubmed

TBL1X: At the crossroads of transcriptional and posttranscriptional regulation.

TBL1XR1 TBL1X

7.19e-07230236206873
Pubmed

Transducin β-like 1, X-linked and nuclear receptor co-repressor cooperatively augment the ligand-independent stimulation of TRH and TSHβ gene promoters by thyroid hormone receptors.

TBL1Y TBL1X

7.19e-07230229794369
Pubmed

Tbl1 promotes Wnt-β-catenin signaling-induced degradation of the Tcf7l1 protein in mouse embryonic stem cells.

TBL1Y TBL1X

2.16e-06330238639717
Pubmed

Transducin β-like protein 1 recruits nuclear factor κB to the target gene promoter for transcriptional activation.

TBL1Y TBL1X

2.16e-06330221189284
Pubmed

Mutant Tbl1x male mice have a short life span and do not breed: unexpected findings.

TBL1Y TBL1X

2.16e-06330238381448
Pubmed

TBL1-TBLR1 and beta-catenin recruit each other to Wnt target-gene promoter for transcription activation and oncogenesis.

TBL1XR1 TBL1X

4.31e-06430218193033
Pubmed

TBL1 and TBLR1 phosphorylation on regulated gene promoters overcomes dual CtBP and NCoR/SMRT transcriptional repression checkpoints.

TBL1XR1 TBL1X

4.31e-06430218374649
Pubmed

Transcriptional co-factor Transducin beta-like (TBL) 1 acts as a checkpoint in pancreatic cancer malignancy.

TBL1Y TBL1X

4.31e-06430226070712
Pubmed

Exchange Factor TBL1 and Arginine Methyltransferase PRMT6 Cooperate in Protecting G Protein Pathway Suppressor 2 (GPS2) from Proteasomal Degradation.

TBL1Y TBL1X

7.18e-06530226070566
Pubmed

A screen for MeCP2-TBL1 interaction inhibitors using a luminescence-based assay.

TBL1XR1 TBL1X

7.18e-06530236890145
Pubmed

SENP2 regulates MMP13 expression in a bladder cancer cell line through SUMOylation of TBL1/TBLR1.

TBL1XR1 TBL1X

7.18e-06530226369384
Pubmed

Histone deacetylase 3 localizes to the mitotic spindle and is required for kinetochore-microtubule attachment.

TBL1XR1 TBL1X

7.18e-06530218326024
Pubmed

Function of multiple Lis-Homology domain/WD-40 repeat-containing proteins in feed-forward transcriptional repression by silencing mediator for retinoic and thyroid receptor/nuclear receptor corepressor complexes.

TBL1XR1 TBL1X

7.18e-06530218202150
Pubmed

Ubiquitin-Independent Disassembly by a p97 AAA-ATPase Complex Drives PP1 Holoenzyme Formation.

ZNF638 LARP1 UIMC1 GSN POLR2C

1.35e-0536130530344098
Pubmed

Mapping of the murine tbl1 gene reveals a new rearrangement between mouse and human X Chromosomes.

TBL1Y TBL1X

1.51e-0573029880679
Pubmed

Reading and function of a histone code involved in targeting corepressor complexes for repression.

TBL1XR1 TBL1X

2.58e-05930215601853
Pubmed

Genome-wide association studies identify loci associated with age at menarche and age at natural menopause.

UIMC1 GCM2

2.58e-05930219448621
Pubmed

The N-CoR-HDAC3 nuclear receptor corepressor complex inhibits the JNK pathway through the integral subunit GPS2.

TBL1XR1 TBL1X

3.22e-051030211931768
Pubmed

N-CoR mediates DNA methylation-dependent repression through a methyl CpG binding protein Kaiso.

TBL1XR1 TBL1X

5.58e-051330214527417
Pubmed

USP44 Is an Integral Component of N-CoR that Contributes to Gene Repression by Deubiquitinating Histone H2B.

TBL1XR1 TBL1X

6.50e-051430227880911
Pubmed

Phosphorylation of thyroid hormone receptor-associated nuclear receptor corepressor holocomplex by the DNA-dependent protein kinase enhances its histone deacetylase activity.

TBL1XR1 TBL1X

7.50e-051530217242407
Pubmed

Purification and functional characterization of the human N-CoR complex: the roles of HDAC3, TBL1 and TBLR1.

TBL1XR1 TBL1X

7.50e-051530212628926
Pubmed

Expression of the semaphorins Sema 3D and Sema 3F in the developing parathyroid and thymus.

SEMA3A GCM2

8.57e-051630218489001
Pubmed

Candidate genes and their regulatory elements: alcohol preference and tolerance.

TBL1Y TBL1X

9.70e-051730216783646
Pubmed

FOXK2 Elicits Massive Transcription Repression and Suppresses the Hypoxic Response and Breast Cancer Carcinogenesis.

TBL1XR1 TBL1X

1.35e-042030227773593
Pubmed

Human transcription factor protein interaction networks.

ZNF638 LARP1 UIMC1 SRCAP TBL1XR1 TBL1Y TBL1X

1.73e-04142930735140242
Pubmed

PRDM16 expression and function in mammalian cochlear development.

SPOCK1 GSN

1.80e-042330235451126
Pubmed

Barx2 functions through distinct corepressor classes to regulate hair follicle remodeling.

TBL1Y TBL1X

1.96e-042430215728386
Pubmed

N-Terminomics for the Identification of In Vitro Substrates and Cleavage Site Specificity of the SARS-CoV-2 Main Protease.

ZNF638 LARP1 SUMF2 GSN

2.50e-0436030433111431
Pubmed

TRIM65 regulates microRNA activity by ubiquitination of TNRC6.

ZNF638 LARP1 IDE LSG1

2.61e-0436430424778252
Pubmed

A direct physical interaction between Nanog and Sox2 regulates embryonic stem cell self-renewal.

TBL1XR1 TBL1Y TBL1X

2.71e-0414630323892456
Pubmed

Estrogen-regulated feedback loop limits the efficacy of estrogen receptor-targeted breast cancer therapy.

FGF1 IDE PP2D1 ZIM3 TRPC6

2.79e-0468630529987050
Pubmed

Endogenous Cell Type-Specific Disrupted in Schizophrenia 1 Interactomes Reveal Protein Networks Associated With Neurodevelopmental Disorders.

SEMA3A LSG1 GSN

3.29e-0415630329961565
Pubmed

Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.

LARP1 SRCAP LSG1 POLR2C

5.34e-0444030434244565
Pubmed

Chemoproteomics profiling of HDAC inhibitors reveals selective targeting of HDAC complexes.

TBL1XR1 TBL1X

6.96e-044530221258344
Pubmed

H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.

ZNF638 UIMC1 SRCAP TBL1XR1 POLR2C TBL1X

7.23e-04129430630804502
Pubmed

An emerin "proteome": purification of distinct emerin-containing complexes from HeLa cells suggests molecular basis for diverse roles including gene regulation, mRNA splicing, signaling, mechanosensing, and nuclear architecture.

TBL1XR1 TBL1X

7.92e-044830217620012
InteractionERF interactions

TBL1XR1 TBL1Y PLEKHG7 TBL1X

1.72e-05105304int:ERF
InteractionTBL1Y interactions

TBL1XR1 TBL1Y TBL1X

2.83e-0540303int:TBL1Y
InteractionARL2 interactions

ZNF638 TBL1XR1 TBCE TBL1X

4.22e-05132304int:ARL2
InteractionH2BC21 interactions

ZNF638 UIMC1 DDX60L SRCAP TBL1XR1 POLR2C TBL1X

5.78e-05696307int:H2BC21
InteractionHDAC3 interactions

PARP14 TBL1XR1 TBL1Y PLEKHG7 TBL1X

9.07e-05313305int:HDAC3
InteractionDKK4 interactions

LARP1 IDE

9.57e-0510302int:DKK4
GeneFamilyWD repeat domain containing

TBL1XR1 TBL1Y IFT172 TBL1X

2.57e-04262224362
CoexpressionGSE9650_EXHAUSTED_VS_MEMORY_CD8_TCELL_UP

GCM2 PTPRJ SPOCK1 POLR2C TBL1X

3.00e-06200305M5838
CoexpressionGSE13485_CTRL_VS_DAY3_YF17D_VACCINE_PBMC_DN

LARP1 DDX60L PARP14 TBCE

7.57e-05199304M3286
CoexpressionGSE9650_GP33_VS_GP276_LCMV_SPECIFIC_EXHAUSTED_CD8_TCELL_UP

FGF1 GCM2 PTPRJ SPOCK1

7.72e-05200304M5842
CoexpressionGSE22589_HEALTHY_VS_HIV_INFECTED_DC_DN

IL1RAPL1 PARP14 IFT172 POLR2C

7.72e-05200304M7807
ToppCellB_cells-ISG-high_B_cells|B_cells / Immune cells in Kidney/Urine in Lupus Nephritis

DDX60L PARP14 PLEKHG7 GSN

8.58e-06195304b64d9e1a8834401b4dc501566546647754ae21fc
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-Oligodendrocyte-Oligodendrocyte-C|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

IL1RAPL1 FGF1 SPOCK1 GSN

8.76e-0619630477feb22fd0b0b1df03375da472134412e9e69c90
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Renal_corpuscle_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

FGF1 SPOCK1 TRPC6

1.52e-0415530390e629681a72baacc7981b82883866a487638dbc
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

FGF1 SPOCK1 TRPC6

1.52e-04155303e7f49e2fdaf184fa6b4e685518004e7deff1316d
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Podocyte|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

FGF1 SPOCK1 TRPC6

1.52e-041553035a872ca70ae8c30b57f45a6772d7bf565e0c2663
ToppCellChildren_(3_yrs)-Epithelial-basal_cell-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

GCM2 TBL1Y TRPC6

1.58e-041573036ee2692f705bdd93ba523dffaf2f0cd921b47e28
ToppCellTCGA-Thymus-Primary_Tumor-Thymoma-Type_C|TCGA-Thymus / Sample_Type by Project: Shred V9

FGF1 PLEKHG7 TRPC6

1.76e-041633032dac87d15051151ccf193760ddd8b82534c3f922
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

FGF1 SPOCK1 TRPC6

1.93e-04168303315ca578c945aeeb77acda2727f3e6db8b43f43e
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

FGF1 SPOCK1 TRPC6

1.93e-04168303fc80e4fecfc92458eb627013a983041d8ca025a9
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Podocyte|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

FGF1 SPOCK1 TRPC6

1.93e-04168303e96859dbf51cf8c4def8ee8db132f4d874fb4381
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

FGF1 SPOCK1 TRPC6

2.07e-041723036c17a1e586a72d1bd80c20c06370429c61dc9f85
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Podocyte|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

FGF1 SPOCK1 TRPC6

2.07e-04172303381ae1c3c07d0a424f43455ec571653b192a946a
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

FGF1 SPOCK1 TRPC6

2.14e-04174303dbdcdec08f1fc69fcdb5d8a6d78df8ef9c374d89
ToppCellRSV-Healthy-1|Healthy / Virus stimulation, Condition and Cluster

DDX60L PARP14 GSN

2.17e-04175303ff3a27f512a3a710ebc863b7b75cce8167d5440b
ToppCellCOVID-19-kidney-Podocyte|COVID-19 / Disease (COVID-19 only), tissue and cell type

FGF1 SPOCK1 TRPC6

2.17e-04175303a73e3a65fd5c1e09cb0c2dae20c1a7bfcae49223
ToppCellRSV-Healthy-1|RSV / Virus stimulation, Condition and Cluster

DDX60L PARP14 GSN

2.17e-04175303ca52b99b03535a5b3a2751d6981708dc5b255b91
ToppCell3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.2.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

GJA9 PLEKHG7 IFT172

2.21e-04176303dee780cfa85234a7cd7bf440b66b84cec959893e
ToppCellBAL-Control-cDC_1|Control / Compartment, Disease Groups and Clusters

DDX60L PARP14 SPOCK1

2.25e-04177303aa021f6d62e9d740c5ea499faaf875de835a2865
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Podocyte|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

FGF1 SPOCK1 TRPC6

2.25e-041773034d2cdb57b427a42085c5f9affa0967b15e84dec3
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

FGF1 SPOCK1 TRPC6

2.29e-04178303edc7143dc9959d36057cb9471681a23afcbc8cce
ToppCell3'-Adult-LargeIntestine-Epithelial-Tuft-related-Tuft|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PTPRJ PLEKHG7 IFT172

2.32e-04179303906555ce2ca264a0215b120c7ff7c9b411de6a34
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

FGF1 SPOCK1 TRPC6

2.32e-041793037394e77e665bf16d3733df91bb12907be460ab44
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Podocyte|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

FGF1 SPOCK1 TRPC6

2.40e-041813035bf7aa43f6e6ecce15c95928b91195544d6928c4
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

FGF1 SPOCK1 TRPC6

2.40e-041813038e751f5d7cd2d328ec0196d874e8a507e8c4e1a9
ToppCell3'-Broncho-tracheal-Mesenchymal-Fibroblastic-fibroblastic_type_1-Adventitial_fibroblasts-Adventitial_fibroblasts_L.2.1.2.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

PP2D1 SPOCK1 GSN

2.44e-04182303d179b5deb07c20d49eb6c58d5a65904f8921de3a
ToppCellCOVID-19-Heart-Fib_+_EC_+_Pericyte|COVID-19 / Disease (COVID-19 only), tissue and cell type

IL1RAPL1 SPOCK1 GSN

2.44e-04182303fbd5e332df73bf7141c822fa67b76367dc962017
ToppCellCOVID-19-kidney-Podocyte|kidney / Disease (COVID-19 only), tissue and cell type

FGF1 SPOCK1 TRPC6

2.48e-04183303fb5e2a31b560126e1c04a386c24c365901c60ad7
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

FGF1 SPOCK1 TRPC6

2.48e-041833033c516fe5083f02bad1f464ed284010b4131a833c
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

FGF1 SPOCK1 TRPC6

2.48e-041833037c4b775f351794a3de06bd503eecbc8ae8577c44
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

FGF1 SPOCK1 TRPC6

2.48e-04183303612d93df03252d4d2ccdce5a9bc162cfd9172a1a
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

FGF1 SPOCK1 TRPC6

2.48e-04183303848fc6dd129150897ee339343e83c645b6e779eb
ToppCellB_cells-ISG-high_B_cells|World / Immune cells in Kidney/Urine in Lupus Nephritis

DDX60L PARP14 PLEKHG7

2.48e-04183303dc2b00e920efa1dcc2a6265cd1024e3249c9974f
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Podocyte|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

FGF1 SPOCK1 TRPC6

2.48e-04183303eb559ae3ae252d9365c24ef557dd49b78ed6d898
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Podocyte|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

FGF1 SPOCK1 TRPC6

2.48e-041833039c2689d76fc6d30f5ab093428aa669d0a98953cf
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Renal_corpuscle_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

FGF1 SPOCK1 TRPC6

2.52e-041843037294b379ce4cb8fa75e432559082f93cd106aaf5
ToppCell5'-Adult-Distal_Rectal-Mesenchymal-fibroblastic-mLN_Stroma_(FMO2+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

FGF1 SPOCK1 GSN

2.56e-041853039faa35ceb89ccd2979072286f063687c9f846ce3
ToppCellLPS-antiTNF-Stromal_mesenchymal-Lung_smooth_muscle-MatrixFB_->_Myofibroblast|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

IL1RAPL1 SPOCK1 TRPC6

2.56e-041853036712512100ccef456d2e2bd201d0987986c92ac9
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

FGF1 SPOCK1 TRPC6

2.56e-04185303b848b63aff4d9dbb9e66a85876d4c7c6dacd0579
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Podocyte|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

FGF1 SPOCK1 TRPC6

2.56e-041853039197f074e769d54031ec41abfc65fcc0c6552c7e
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

FGF1 SPOCK1 TRPC6

2.56e-04185303ce7d62394b09c26ca65b8cdb280afec5e25bbb62
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-OPC-OPC-D|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

IL1RAPL1 PP2D1 ZIM3

2.64e-041873036c43669e19b5b54d72d1f5d876184fee53c05f0b
ToppCellkidney_cells-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Podocyte|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

FGF1 SPOCK1 TRPC6

2.64e-0418730324c2a3962da364e46e98abeab5f8234376fa26bb
ToppCellCOVID-19-Heart-Fib_1|COVID-19 / Disease (COVID-19 only), tissue and cell type

IL1RAPL1 SPOCK1 GSN

2.68e-04188303fe361215f4ba841aa5e1e581fb56f2f4d3ccd201
ToppCellASK454-Endothelial-Lymphatic|Endothelial / Donor, Lineage and Cell class of Lung cells from Dropseq

SEMA3A SUMF2 AGBL3

2.72e-04189303316c857dec9383823e09f966bca62d52d933b141
ToppCell10x_3'_v2v3-Non-neoplastic-Glial-Neuronal-Oligodendrocyte-Oligodendrocyte-D|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

FGF1 SPOCK1 GSN

2.90e-04193303947200ef6c3a2e35ad7e6b4af29d92384bdf73f5
ToppCellPCW_07-8.5-Mesenchymal-Mesenchymal_fibroblastic-mes_immature1_(0)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

SEMA3A IL1RAPL1 TRPC6

2.94e-04194303a3e5a15cf6c1361207f661ee15eb634f77daf1cb
ToppCell18-Distal-Mesenchymal-Pericyte|Distal / Age, Tissue, Lineage and Cell class

FGF1 GSN TRPC6

2.99e-04195303e0ee7905499ee1a1ca7b1184e2713028cf156985
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-Oligodendrocyte-Oligodendrocyte-A|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

FGF1 SPOCK1 GSN

2.99e-041953031e28617ca55e5f318a228357737b968dfac8cca0
ToppCellmild-Myeloid-Neutrophils_2|Myeloid / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

RNF10 DDX60L PARP14

3.03e-04196303ded44b38ea489946e9eedfe752b5a9fde9149c16
ToppCellEnterocyte-C_05|Enterocyte / shred on cell type and cluster

DDX60L PARP14 GSN

3.03e-04196303c307e5a70186567c62da938caa21749dc0e929d0
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-Oligodendrocyte-Oligodendrocyte-B|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

IL1RAPL1 SPOCK1 GSN

3.08e-04197303032ccc91e604113da9bc34a6f9ddb1d45dea1892
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-Oligodendrocyte-Oligodendrocyte-D|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

IL1RAPL1 FGF1 GSN

3.08e-0419730354fb207638e211f8efdb13003ae62a6b1f003b09
ToppCellPCW_10-12-Mesenchymal-Mesenchymal_fibroblastic-mes_immature1_(0)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

SEMA3A IL1RAPL1 TBL1XR1

3.08e-0419730311a4c417f035e554431a8f03be13b5eefa3530c0
ToppCellsevere|World / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

RNF10 DDX60L PARP14

3.17e-04199303c24aacef7405700bc5d0b736a38feea12b7f17c8
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

FGF1 SPOCK1 GSN

3.22e-04200303acdef0b9096c774040948fc75621ff2b08ea2ee8
ToppCell10x_3'_v2v3-Non-neoplastic-Glial-Neuronal-Oligodendrocyte-Oligodendrocyte-F|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

FGF1 SPOCK1 GSN

3.22e-042003033ce8a2db8c25e1169a0a544f644a63104749c5ee
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-Oligodendrocyte-Oligodendrocyte|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

FGF1 SPOCK1 GSN

3.22e-04200303091a18d6efed81cab99955c3047f172170f70476
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-Oligodendrocyte|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

FGF1 SPOCK1 GSN

3.22e-042003033b8513defe25262ab4b492345b2628570eaefd17
Diseasesensory system disease (implicated_via_orthology)

TBL1XR1 TBL1Y TBL1X

9.48e-103303DOID:0050155 (implicated_via_orthology)
Diseasesalicylurate measurement

ZNF638 FGF1

7.74e-0513302EFO_0010532
DiseaseMesothelioma

FGF1 GSN

7.99e-0441302C0025500
DiseaseAutism Spectrum Disorders

IL1RAPL1 TBL1X

3.39e-0385302C1510586
DiseaseNeurodevelopmental Disorders

SRCAP TBL1XR1

4.04e-0393302C1535926

Protein segments in the cluster

PeptideGeneStartEntry
GPKKNKHSQIWAIKN

AGBL3

916

Q8NEM8
GGQKKKGNKHKWVPL

LARP1

241

Q6PKG0
GGFIFWRKKRKDAKN

PTPRJ

991

Q12913
NGAGKPWKKHGNRNK

LSG1

631

Q9H089
KRGLFHNLCKPAWKG

DDX60L

1441

Q5H9U9
VIKWHGPKCNKLNSK

IL1RAPL1

536

Q9NZN1
KRPGKAANKDNWNKF

IFT172

1701

Q9UG01
GKKWKGLTHNLLKKQ

PARP14

611

Q460N5
FHLGFKKIKRGLWGK

GJA9

231

P57773
HGKDGKIFVWKGKQA

GSN

336

P06396
KKWQNADLNGKFKLP

IDE

511

P14735
NRTNLWQGKFPKGDK

SUMF2

191

Q8NBJ7
GHGKNRAKWGLLKNI

TRIM42

701

Q8IWZ5
FTNKQHGWKPALGKP

GCM2

326

O75603
KHAEKNWFVGLKKNG

FGF1

116

P05230
PGNSNKWKHLQENKK

SEMA3A

741

Q14563
KLKRQGWTKPNAFHV

SRCAP

706

Q6ZRS2
KGPIFALKWNKKGNF

TBL1XR1

266

Q9BZK7
KKGFGKEHAKWNPTA

POLR2C

166

P19387
GQHKGPIFALKWNRK

TBL1X

326

O60907
GRAFGEKWKLDKHQK

ZIM3

201

Q96PE6
RKAFGNEWKQAGGHK

TBCE

386

Q15813
GKRNKWGHKPFNKEL

RNF10

166

Q8N5U6
RQKKGNVAQKHWVGP

SPOCK1

116

Q08629
KGPIFALKWNKKGNY

TBL1Y

276

Q9BQ87
WPFSKRGVGKDKHKH

PLEKHG7

226

Q6ZR37
KKWISELFQGHKKGF

TRPC6

781

Q9Y210
GKWQQRLKNPKEKGH

UIMC1

606

Q96RL1
EAQQKKGKPHGSRWD

ZNF638

91

Q14966
GKPKSPYAHKNWKRK

PP2D1

321

A8MPX8