Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	RhoGAP	SRGAP1 OPHN1	8.97e-03	62	43	2	SM00324
Domain	RhoGAP	SRGAP1 OPHN1	9.25e-03	63	43	2	PF00620
Domain	RHOGAP	SRGAP1 OPHN1	9.54e-03	64	43	2	PS50238
Domain	RhoGAP_dom	SRGAP1 OPHN1	9.54e-03	64	43	2	IPR000198
Domain	-	SRGAP1 OPHN1	9.54e-03	64	43	2	1.10.555.10
Domain	USP_CS	USP10 USP15	1.01e-02	66	43	2	IPR018200
Domain	USP_1	USP10 USP15	1.13e-02	70	43	2	PS00972
Domain	UCH	USP10 USP15	1.16e-02	71	43	2	PF00443
Domain	USP_2	USP10 USP15	1.16e-02	71	43	2	PS00973
Domain	USP_3	USP10 USP15	1.20e-02	72	43	2	PS50235
Domain	USP_dom	USP10 USP15	1.20e-02	72	43	2	IPR028889
Domain	Peptidase_C19_UCH	USP10 USP15	1.20e-02	72	43	2	IPR001394
Pubmed	Macrodomain-containing proteins are new mono-ADP-ribosylhydrolases.	PARG MACROD2	1.03e-05	4	46	2	23474714
Pubmed	A conserved acetylation switch enables pharmacological control of tubby-like protein stability.	TLK2 PJA2 UBR5 COPS2 PDE4DIP	1.15e-05	223	46	5	33187986
Pubmed	Two novel transcripts encoding two Ankyrin repeat containing proteins have preponderant expression during the mouse spermatogenesis.	POTEM POTEG	2.56e-05	6	46	2	17171436
Pubmed	Expression of mouse dchs1, fjx1, and fat-j suggests conservation of the planar cell polarity pathway identified in Drosophila.	DCHS2 FAT2	3.58e-05	7	46	2	16059920
Pubmed	USP4 Auto-Deubiquitylation Promotes Homologous Recombination.	NBN USP15	4.77e-05	8	46	2	26455393
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	TLK2 NBN USP10 DHX29 CHAF1A WTAP PARG	6.62e-05	774	46	7	15302935
Pubmed	MRE11 complex links RECQ5 helicase to sites of DNA damage.	NBN UBR5	9.34e-05	11	46	2	19270065
Pubmed	FBXO42 facilitates Notch signaling activation and global chromatin relaxation by promoting K63-linked polyubiquitination of RBPJ.	TLK2 COPS2 CHAF1A PARG	1.02e-04	183	46	4	36129980
Pubmed	Overexpression of COP9 signalosome subunits, CSN7A and CSN7B, exerts different effects on adipogenic differentiation.	USP15 COPS2	1.32e-04	13	46	2	27833851
Pubmed	Amyloid Precursor Protein (APP) May Act as a Substrate and a Recognition Unit for CRL4CRBN and Stub1 E3 Ligases Facilitating Ubiquitination of Proteins Involved in Presynaptic Functions and Neurodegeneration.	USP10 UBR5 COPS2	1.60e-04	79	46	3	27325702
Pubmed	Deubiquitinating enzymes: a new class of biological regulators.	USP10 USP15	1.78e-04	15	46	2	9827704
Pubmed	Identification of a novel actin isoform in hepatocellular carcinoma.	POTEM POTEG	1.78e-04	15	46	2	16824795
Pubmed	Cloning and characterization of 13 novel transcripts and the human RGS8 gene from the 1q25 region encompassing the hereditary prostate cancer (HPC1) locus.	EDEM3 NIBAN1	1.78e-04	15	46	2	11318611
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	PJA2 TENM3 UBR5 USP15 PDE4DIP	1.98e-04	407	46	5	12693553
Pubmed	The COP9 signalosome mediates beta-catenin degradation by deneddylation and blocks adenomatous polyposis coli destruction via USP15.	USP15 COPS2	2.03e-04	16	46	2	19576224
Pubmed	Requirement of FAT and DCHS protocadherins during hypothalamic-pituitary development.	DCHS2 FAT2	2.58e-04	18	46	2	33108146
Pubmed	Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.	USP10 UBR5 USP15 DHX29 TSPYL2	2.83e-04	440	46	5	34244565
Pubmed	Ubiquitin-specific protease 7 sustains DNA damage response and promotes cervical carcinogenesis.	NBN UBR5	3.54e-04	21	46	2	30179224
Pubmed	Genome-wide association study identifies variants associated with histologic features of nonalcoholic Fatty liver disease.	SLC9A9 MACROD2	3.54e-04	21	46	2	20708005
Pubmed	Large scale discovery of coronavirus-host factor protein interaction motifs reveals SARS-CoV-2 specific mechanisms and vulnerabilities.	RDX USP10	3.89e-04	22	46	2	34799561
Pubmed	CRL4AMBRA1 targets Elongin C for ubiquitination and degradation to modulate CRL5 signaling.	PJA2 UBR5 COPS2	4.01e-04	108	46	3	30166453
Pubmed	TRIM11 activates the proteasome and promotes overall protein degradation by regulating USP14.	USP10 USP15	4.25e-04	23	46	2	29581427
Pubmed	OTUB1 modulates c-IAP1 stability to regulate signalling pathways.	UBR5 USP15	4.64e-04	24	46	2	23524849
Pubmed	USP10 regulates B cell response to SARS-CoV-2 or HIV-1 nanoparticle vaccines through deubiquitinating AID.	USP10 USP15	4.64e-04	24	46	2	34983926
Pubmed	Identification of targets for calcium signaling through the copine family of proteins. Characterization of a coiled-coil copine-binding motif.	RDX WTAP	5.04e-04	25	46	2	12522145
Pubmed	A probability-based approach for high-throughput protein phosphorylation analysis and site localization.	NBN USP10 USP15 DHX29 CHAF1A	5.22e-04	503	46	5	16964243
Pubmed	HENA, heterogeneous network-based data set for Alzheimer's disease.	APBA1 KIF3C PDE4DIP	5.46e-04	120	46	3	31413325
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	EDEM3 NBN PJA2 TAF7 UBR5 CHAF1A TSPYL2	6.16e-04	1116	46	7	31753913
Pubmed	Genome-wide association study of lung function decline in adults with and without asthma.	TAF7 USP15	8.28e-04	32	46	2	22424883
Pubmed	Ubiquitin-specific peptidase 2a (USP2a) deubiquitinates and stabilizes β-catenin.	USP10 USP15	8.80e-04	33	46	2	30323974
Pubmed	Discovery and Characterization of ZUFSP/ZUP1, a Distinct Deubiquitinase Class Important for Genome Stability.	USP10 UBR5 USP15	9.83e-04	147	46	3	29576527
Cytoband	1q25	EDEM3 NIBAN1	3.14e-04	26	46	2	1q25
Cytoband	10q11.23	FAM170B PARG	5.08e-04	33	46	2	10q11.23
GeneFamily	Ankyrin repeat domain containing\|POTE ankyrin domain containing	POTEM POTEG	1.31e-04	13	24	2	685
GeneFamily	Cadherin related	DCHS2 FAT2	2.27e-04	17	24	2	24
GeneFamily	Rho GTPase activating proteins\|BCH domain containing	SRGAP1 OPHN1	1.99e-03	50	24	2	721
GeneFamily	Ubiquitin specific peptidases	USP10 USP15	2.49e-03	56	24	2	366
CoexpressionAtlas	DevelopingKidney_e15.5_Cap mesenchyme_emap-27738_k-means-cluster#2_top-relative-expression-ranked_500	TLK2 TAF7 DISP1 SRGAP1 ENC1 MACROD2	1.32e-06	166	45	6	gudmap_developingKidney_e15.5_Cap mesenchyme_500_k2
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)-Glut_D_(IT_RORB_THEMIS_LINC00507)_6\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	DCHS2 TENM3 FAM241A ENC1	3.25e-05	176	46	4	0710689e66deba179b0a8038cdd56b4834984f12
ToppCell	primary_visual_cortex-Neuronal-glutamatergic_neuron-L6_IT-L6_IT_VISp_Penk_Fst\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	TENM3 DISP1 FAM241A ENC1	3.25e-05	176	46	4	a1b9f8f199a028b3fa85de43fe96bc29f387bfd8
ToppCell	5'-Adult-Appendix-Hematopoietic-Myeloid-cDC1\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	APBA1 SLC9A9 DISP1 SRGAP1	3.32e-05	177	46	4	345cebc19f93970a9a46be139208b300081f5493
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	DCHS2 TENM3 FAM241A ENC1	3.32e-05	177	46	4	f30d757ee8db7e10d547498dab6560473c6ed7c0
ToppCell	droplet-Marrow-nan-24m-Lymphocytic-naive_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EDEM3 SLC9A9 NIBAN1 DISP1	3.39e-05	178	46	4	cc0382b0ee1e6c76522e2c86ad1425c45debab5d
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)-Glut_D_(IT_RORB_THEMIS_LINC00507)_6\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	DCHS2 TENM3 FAM241A ENC1	3.47e-05	179	46	4	1ac79c82c52fa95bb4e170ab20fec0f648db2134
ToppCell	COVID-19-kidney-Epi_(Mes)\|kidney / Disease (COVID-19 only), tissue and cell type	APBA1 DCHS2 TENM3 SRGAP1	3.47e-05	179	46	4	e7c9dc63f03d3f3746b51a7e3c8393089e2ceb7d
ToppCell	10x_3'_v3-blood_(10x_3'_v3)-myeloid-myeloid_granulocytic-granulocyte\|blood_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	APBA1 SLC9A9 DISP1 CHAF1A	3.47e-05	179	46	4	140dd7dbac48f5f07279f31bf971d7fbd41fa18b
ToppCell	10x5'-Liver-Lymphocytic_T_CD4-T_CD4/CD8\|Liver / Manually curated celltypes from each tissue	UBR5 USP15 RNF207 TSPYL2	3.62e-05	181	46	4	f2315414e714ac86211546a935660c4be6e85f1b
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)-Glut_D_(IT_RORB_THEMIS_LINC00507)_6-Exc_L6_THEMIS_LINC00343\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	DCHS2 TENM3 FAM241A ENC1	3.62e-05	181	46	4	9de2f2cc5f02e0ca599c9e0d2cb1e1e4b5aac112
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	APBA1 TENM3 SRGAP1 PDE4DIP	3.78e-05	183	46	4	7c4b775f351794a3de06bd503eecbc8ae8577c44
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	APBA1 TENM3 SRGAP1 PDE4DIP	3.95e-05	185	46	4	b848b63aff4d9dbb9e66a85876d4c7c6dacd0579
ToppCell	COVID-19-Epithelial-Club,_Basal_cells\|Epithelial / Condition, Lineage and Cell class	NIBAN1 FAT2 RNF207 OPHN1	5.04e-05	197	46	4	78ed2810e5a765327e7a6da0ca5d4854bf7a0b6f
ToppCell	COVID-19_Mild-PLT_4\|COVID-19_Mild / Disease Group and Platelet Clusters	SLC9A9 USP15 DHX29 WTAP	5.14e-05	198	46	4	3d8c33dba759df0974aeb2b9a6b5167ae7a18e1f
ToppCell	LPS_IL1RA-Mesenchymal_fibroblastic-Fibroblasts-Activated_MatrixFB\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	TENM3 SRGAP1 WTAP TSPYL2	5.24e-05	199	46	4	8b86c69aaf60feff53aa782559cfece7342a23de
ToppCell	Brain_organoid-organoid_Paulsen_bioRxiv-3.5_mon-Neuronal-CPNs\|3.5_mon / Sample Type, Dataset, Time_group, and Cell type.	KIF3C SRGAP1 FAM241A ENC1	5.34e-05	200	46	4	71cbefbef4ae5bbb5f6e419914f4b3b3b5a5f9e3
Computational	Neighborhood of AQP4	RDX GOLM2 PDE4DIP	1.48e-04	45	25	3	GCM_AQP4
Computational	Neighborhood of IL6ST	RDX PJA2 GOLM2	2.69e-04	55	25	3	GCM_IL6ST
Computational	Neighborhood of RAB10	EDEM3 RDX UBR5 GOLM2	6.71e-04	176	25	4	GCM_RAB10
Disease	cerebrospinal fluid biomarker measurement, monocyte chemotactic protein 1 measurement	EDEM3 NIBAN1	2.96e-05	6	42	2	EFO_0006794, EFO_0010596
Disease	medial orbital frontal cortex volume measurement	FAT2 MACROD2	5.81e-04	25	42	2	EFO_0010315
Disease	bitter beverage consumption measurement	EDEM3 NIBAN1	1.64e-03	42	42	2	EFO_0010089
Disease	response to angiotensin-converting enzyme inhibitor, Cough	NIBAN1 KIF3C	1.97e-03	46	42	2	EFO_0005325, HP_0012735
Disease	non-alcoholic fatty liver disease, cirrhosis of liver	SLC9A9 MACROD2	2.60e-03	53	42	2	EFO_0001422, EFO_0003095
Disease	colon cancer (is_marker_for)	UBR5 CHAF1A	3.21e-03	59	42	2	DOID:219 (is_marker_for)
Disease	cognitive function measurement	APBA1 TLK2 EDEM3 KIF3C SRGAP1 RAB33B MACROD2	3.82e-03	1434	42	7	EFO_0008354
Disease	Epstein-Barr virus infection	NIBAN1 MACROD2	4.00e-03	66	42	2	EFO_0000769
Disease	radiation-induced disorder	DCHS2 MACROD2	4.12e-03	67	42	2	EFO_0009565
Disease	serum IgG glycosylation measurement	SLC9A9 TXLNB TENM3 USP15	6.41e-03	523	42	4	EFO_0005193

Protein segments in the cluster

Peptide	Gene	Start	Entry
SEDSNSEPNVDLENQ	COPS2	21	P61201
QDIQQLSSEENDHPF	ASGR2	6	P07307
EDSNEQPDSLVDHNK	CHAF1A	121	Q13111
QQQHSENKRENSEDP	DHX29	506	Q7Z478
TDASVNSEHFNQNEP	DISP1	1446	Q96F81
ETSAKNPNDNDHVEA	RAB33B	176	Q9H082
SLDESEDEIQHQTPN	OPHN1	606	O60890
QHQSEGNPDKSEESQ	LUZP4	136	Q9P127
PTENEHDEHDENNAE	RDX	481	P35241
PEDDSNTANHNLEQV	CACNA1F	116	O60840
DQESSEENSLNSHPE	EDEM3	831	Q9BZQ6
VAEEEDDNNNNHRPP	KIF3C	431	O14782
EDVNDNSPQCITEHN	FAT2	916	Q9NYQ8
NIDRSPQNDDHSDTD	PARG	186	Q86W56
PQNDDHSDTDSEENR	PARG	191	Q86W56
QPDQQQDHETTDSSP	LCT	341	P09848
HDQQLEEEQSPSDNS	FAM170B	251	A6NMN3
EDQNDHSPSFQDELI	DCHS2	1501	Q6V1P9
PKESEQDVEDSQNHT	FAM241A	46	Q8N8J7
SNNAELQHEDESVPE	CCDC30	666	Q5VVM6
SNSQENVEASHPSQD	APBA1	566	Q02410
ESQDSEVNFDNSIHP	ENC1	81	O14682
HQSNDTDSSHDPQEE	WTAP	351	Q15007
VRDQDHPDGQENDST	MACROD2	321	A1Z1Q3
ADTEQQDHTSPNEND	HSFX1	236	Q9UBD0
AENVADKNEEPSSNH	GOLM2	221	Q6P4E1
LNESDEQHQENEGTN	TAF7	261	Q15545
VDEQSESLQNTHDDS	RNF207	556	Q6ZRF8
ENPLADDQSNHDINS	SRGAP1	561	Q7Z6B7
DENLKEDPSSQHQEA	SLC9A9	496	Q8IVB4
EDPSSQHQEANNLDK	SLC9A9	501	Q8IVB4
QHLSENEPVDTNSDN	NBN	506	O60934
ADQQPENHEVDTSVS	RIMOC1	226	A6NDU8
HDDQEDISPSLAEQQ	GPAM	661	Q9HCL2
NEDNSQFKDHPTLND	TLK2	446	Q86UE8
GKEESQHQQPDDSNN	CNBD1	96	Q8NA66
NPDHNEVPNNETTDN	TSPYL2	481	Q9H2G4
EEDTNGESHVPQENE	NIBAN1	731	Q9BZQ8
SSDLNENQHPLDFDE	VN1R1	26	Q9GZP7
SQDQELPSENENSQS	USP15	666	Q9Y4E8
EHENKSDSENEQPAS	TENM3	161	Q9P273
SNGPKNHSVNEEEQE	USP10	556	Q14694
KDDQSQHNSDEEPES	TXLNB	466	Q8N3L3
QHNSDEEPESNVSVD	TXLNB	471	Q8N3L3
PDTENEQYHSDEQND	POTEG	461	Q6S5H5
PDTENEQYHSDEQND	POTEM	461	A6NI47
NNTSQERQTEHSPED	PJA2	271	O43164
EHENDDDTNQSATLN	UBR5	1991	O95071
TVDAHQLDNQSQPRD	PDE4DIP	1186	Q5VU43