Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionP-type calcium transporter activity

ATP13A4 ATP2B1 ATP2B2

2.26e-0611493GO:0005388
GeneOntologyMolecularFunctionP-type transmembrane transporter activity

ATP13A4 ATP2B1 ATP2B2

9.37e-0536493GO:0140358
GeneOntologyMolecularFunctionP-type ion transporter activity

ATP13A4 ATP2B1 ATP2B2

9.37e-0536493GO:0015662
GeneOntologyMolecularFunctionaspartic-type endopeptidase activity

ERVK-8 ERVK-18 ERVK-9

1.02e-0437493GO:0004190
GeneOntologyMolecularFunctionaspartic-type peptidase activity

ERVK-8 ERVK-18 ERVK-9

1.10e-0438493GO:0070001
GeneOntologyMolecularFunctionIgG receptor activity

FCGR2C FCGR2B

1.23e-047492GO:0019770
GeneOntologyMolecularFunctionIgG binding

FCGR2C FCGR2B

3.20e-0411492GO:0019864
GeneOntologyMolecularFunctionATPase-coupled monoatomic cation transmembrane transporter activity

ATP13A4 ATP2B1 ATP2B2

4.74e-0462493GO:0019829
GeneOntologyMolecularFunctionimmunoglobulin receptor activity

FCGR2C FCGR2B

5.27e-0414492GO:0019763
GeneOntologyMolecularFunctionendopeptidase activity

ADGB RHBDF1 ERVK-8 ERVK-18 ERVK-9 USP37

6.15e-04430496GO:0004175
GeneOntologyMolecularFunctionpeptidase activity

ADGB RHBDF1 ERVK-8 ERVK-18 ERVK-9 USP37 MINDY1

1.02e-03654497GO:0008233
GeneOntologyMolecularFunctioncalmodulin binding

EGFR CAMSAP1 ATP2B1 ATP2B2

2.42e-03230494GO:0005516
GeneOntologyMolecularFunctionATPase-coupled transmembrane transporter activity

ATP13A4 ATP2B1 ATP2B2

2.43e-03109493GO:0042626
DomainCation_ATPase_N

ATP13A4 ATP2B1 ATP2B2

1.11e-0518463PF00690
DomainCation_ATPase_N

ATP13A4 ATP2B1 ATP2B2

1.11e-0518463SM00831
DomainATPase_P-typ_cation-transptr_N

ATP13A4 ATP2B1 ATP2B2

1.32e-0519463IPR004014
DomainATP_Ca_trans_C

ATP2B1 ATP2B2

3.55e-054462IPR022141
DomainATP_Ca_trans_C

ATP2B1 ATP2B2

3.55e-054462PF12424
DomainP-type_ATPase_IIB

ATP2B1 ATP2B2

3.55e-054462IPR006408
Domain-

ATP13A4 ATP2B1 ATP2B2

6.60e-05324633.40.1110.10
Domain-

ATP13A4 ATP2B1 ATP2B2

6.60e-05324632.70.150.10
DomainATPase_P-typ_cyto_domN

ATP13A4 ATP2B1 ATP2B2

8.66e-0535463IPR023299
DomainP_typ_ATPase

ATP13A4 ATP2B1 ATP2B2

9.43e-0536463IPR001757
DomainATPase_P-typ_P_site

ATP13A4 ATP2B1 ATP2B2

9.43e-0536463IPR018303
DomainATPASE_E1_E2

ATP13A4 ATP2B1 ATP2B2

9.43e-0536463PS00154
DomainATPase_P-typ_transduc_dom_A

ATP13A4 ATP2B1 ATP2B2

1.02e-0437463IPR008250
DomainE1-E2_ATPase

ATP13A4 ATP2B1 ATP2B2

1.02e-0437463PF00122
Domain-

ATP2B1 ATP2B2

6.97e-04164621.20.1110.10
DomainATPase_P-typ_TM_dom

ATP2B1 ATP2B2

6.97e-0416462IPR023298
DomainCH

MICALL1 CFAP47 CAMSAP1

7.71e-0473463PS50021
DomainATPase_P-typ_cation-transptr_C

ATP2B1 ATP2B2

7.88e-0417462IPR006068
DomainCation_ATPase_C

ATP2B1 ATP2B2

7.88e-0417462PF00689
DomainCH-domain

MICALL1 CFAP47 CAMSAP1

8.34e-0475463IPR001715
DomainHAD-like_dom

ATP13A4 ATP2B1 ATP2B2

9.70e-0479463IPR023214
DomainQuinoprotein_ADH-like_supfam

WDR87 EIF2AK3

7.55e-0353462IPR011047
DomainL_dom-like

NLRP9 EGFR KDM2A XRRA1

8.53e-03328464IPR032675
DomainC1_1

DGKI PRKCE

8.69e-0357462PF00130
Domain-

SELENBP1 WDR87 TAF1C SEC31A

8.99e-033334642.130.10.10
DomainWD40/YVTN_repeat-like_dom

SELENBP1 WDR87 TAF1C SEC31A

9.17e-03335464IPR015943
PathwayWP_GASTRIC_CANCER_NETWORK_2

BRIX1 EGFR CD48

5.04e-0532323M39497
PathwayREACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES

ATP13A4 ATP2B1 ATP2B2

2.57e-0455323M971
PathwayREACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES

ATP13A4 ATP2B1 ATP2B2

2.86e-0457323MM15643
PathwayREACTOME_REDUCTION_OF_CYTOSOLIC_CA_LEVELS

ATP2B1 ATP2B2

3.25e-0412322M27326
PathwayREACTOME_REDUCTION_OF_CYTOSOLIC_CA_LEVELS

ATP2B1 ATP2B2

4.47e-0414322MM15052
PathwayREACTOME_SHC1_EVENTS_IN_ERBB2_SIGNALING

EGFR PRKCE

4.47e-0414322MM14531
PathwayPID_TELOMERASE_PATHWAY

HUS1 EGFR SMAD3

4.61e-0467323M105
Pubmed

Human IgG Fc receptor (hFcRII; CD32) exists as multiple isoforms in macrophages, lymphocytes and IgG-transporting placental epithelium.

FCGR2C FCGR2B

2.11e-0625122531080
Pubmed

Expression of functional CD32 molecules on human NK cells is determined by an allelic polymorphism of the FcgammaRIIC gene.

FCGR2C FCGR2B

2.11e-0625129516136
Pubmed

Human rhomboid family-1 gene RHBDF1 participates in GPCR-mediated transactivation of EGFR growth signals in head and neck squamous cancer cells.

RHBDF1 EGFR

2.11e-06251218832597
Pubmed

WDR87 interacts with CFAP47 protein in the middle piece of spermatozoa flagella to participate in sperm tail assembly.

CFAP47 WDR87

2.11e-06251236571501
Pubmed

Trafficking of presynaptic PMCA signaling complexes in mouse photoreceptors requires Cav1.4 α1 subunits.

ATP2B1 ATP2B2

6.32e-06351222183401
Pubmed

Protein kinase C phosphorylates the carboxyl terminus of the plasma membrane Ca(2+)-ATPase from human erythrocytes.

ATP2B1 ATP2B2

6.32e-0635121827443
Pubmed

Plasma membrane Ca2+ ATPase isoform 2b interacts preferentially with Na+/H+ exchanger regulatory factor 2 in apical plasma membranes.

ATP2B1 ATP2B2

6.32e-06351211786550
Pubmed

Nonallelic homologous recombination of the FCGR2/3 locus results in copy number variation and novel chimeric FCGR2 genes with aberrant functional expression.

FCGR2C FCGR2B

6.32e-06351226133275
Pubmed

Plasma Membrane Calcium ATPase-Neuroplastin Complexes Are Selectively Stabilized in GM1-Containing Lipid Rafts.

ATP2B1 ATP2B2

6.32e-06351234948386
Pubmed

Genomic pathology of SLE-associated copy-number variation at the FCGR2C/FCGR3B/FCGR2B locus.

FCGR2C FCGR2B

6.32e-06351223261299
Pubmed

Functional Fcgamma receptor polymorphisms are associated with human allergy.

FCGR2C FCGR2B

6.32e-06351224586589
Pubmed

Cell-specific expression of plasma membrane calcium ATPase isoforms in retinal neurons.

ATP2B1 ATP2B2

1.26e-05451212209837
Pubmed

Expression and role of calcium-ATPase pump and sodium-calcium exchanger in differentiated trophoblasts from human term placenta.

ATP2B1 ATP2B2

1.26e-05451212784250
Pubmed

The plasma membrane calcium pump in health and disease.

ATP2B1 ATP2B2

1.26e-05451223413890
Pubmed

PSD95beta regulates plasma membrane Ca2+ pump localization at the photoreceptor synapse.

ATP2B1 ATP2B2

1.26e-05451219233278
Pubmed

Quantitative analysis of alternative splicing options of human plasma membrane calcium pump genes.

ATP2B1 ATP2B2

1.26e-0545128245032
Pubmed

Quantitative analysis of alternative splicing options of human plasma membrane calcium pump genes.

ATP2B1 ATP2B2

1.26e-0545127989379
Pubmed

Role of alternative splicing in generating isoform diversity among plasma membrane calcium pumps.

ATP2B1 ATP2B2

1.26e-05451211152753
Pubmed

PMCA1 depletion in mouse eggs amplifies calcium signaling and impacts offspring growth†.

ATP2B1 ATP2B2

1.26e-05451236130203
Pubmed

Developmental expression of the four plasma membrane calcium ATPase (Pmca) genes in the mouse.

ATP2B1 ATP2B2

1.26e-05451210434059
Pubmed

HER2/EGFR-AKT Signaling Switches TGFβ from Inhibiting Cell Proliferation to Promoting Cell Migration in Breast Cancer.

EGFR SMAD3

1.26e-05451230171053
Pubmed

Calcium pumps of plasma membrane and cell interior.

ATP2B1 ATP2B2

1.26e-05451215101689
Pubmed

Plasma membrane calcium ATPases as critical regulators of calcium homeostasis during neuronal cell function.

ATP2B1 ATP2B2

1.26e-05451210577388
Pubmed

Structural organization, ion transport, and energy transduction of P-type ATPases.

ATP2B1 ATP2B2

1.26e-0545128634322
Pubmed

iRhoms 1 and 2 are essential upstream regulators of ADAM17-dependent EGFR signaling.

RHBDF1 EGFR

1.26e-05451225918388
Pubmed

Characterization of a human rhomboid homolog, p100hRho/RHBDF1, which interacts with TGF-alpha family ligands.

RHBDF1 EGFR

2.10e-05551215965977
Pubmed

Mouse oocytes enable LH-induced maturation of the cumulus-oocyte complex via promoting EGF receptor-dependent signaling.

EGFR SMAD3

2.10e-05551220382892
Pubmed

C-Reactive Protein Promotes Diabetic Kidney Disease in db/db Mice via the CD32b-Smad3-mTOR signaling Pathway.

FCGR2B SMAD3

2.10e-05551227221338
Pubmed

Copy number variation at the FCGR locus includes FCGR3A, FCGR2C and FCGR3B but not FCGR2A and FCGR2B.

FCGR2C FCGR2B

2.10e-05551219309690
Pubmed

RUNX3-mediated up-regulation of miR-29b suppresses the proliferation and migration of gastric cancer cells by targeting KDM2A.

KDM2A SMAD3

2.10e-05551227497248
Pubmed

Differential regulation of the apical plasma membrane Ca(2+) -ATPase by protein kinase A in parotid acinar cells.

ATP2B1 ATP2B2

2.10e-05551217938178
Pubmed

SNPs of Fc-gamma receptor genes and chronic periodontitis.

FCGR2C FCGR2B

2.10e-05551220439936
Pubmed

Copy number, linkage disequilibrium and disease association in the FCGR locus.

FCGR2C FCGR2B

2.10e-05551220508037
Pubmed

Characterization of PISP, a novel single-PDZ protein that binds to all plasma membrane Ca2+-ATPase b-splice variants.

ATP2B1 ATP2B2

3.15e-05651212763866
Pubmed

Cardiac excitation-contraction coupling in the absence of Na(+) - Ca2+ exchange.

ATP2B1 ATP2B2

3.15e-05651212767889
Pubmed

Diacylglycerol kinase θ counteracts protein kinase C-mediated inactivation of the EGF receptor.

EGFR PRKCE

3.15e-05651222732145
Pubmed

ER stress disrupts Ca2+-signaling complexes and Ca2+ regulation in secretory and muscle cells from PERK-knockout mice.

ATP2B1 EIF2AK3

3.15e-05651216352659
Pubmed

EGFR-induced and PKCε monoubiquitylation-dependent NF-κB activation upregulates PKM2 expression and promotes tumorigenesis.

EGFR PRKCE

4.41e-05751223123196
Pubmed

Protein kinase Cdelta is responsible for constitutive and DNA damage-induced phosphorylation of Rad9.

HUS1 PRKCE

4.41e-05751212628935
Pubmed

The expression of Pax6 variants is subject to posttranscriptional regulation in the developing mouse eyelid.

EGFR SMAD3

5.87e-05851223326536
Pubmed

Chromosome mapping of Rmp-4, a gonad-dependent gene encoding host resistance to mousepox.

FCGR2B CD48

5.87e-0585127474114
Pubmed

Gene knockout studies of Ca2+-transporting ATPases.

ATP2B1 ATP2B2

5.87e-05851210951186
Pubmed

A novel role for the peptidyl-prolyl cis-trans isomerase Cyclophilin A in DNA-repair following replication fork stalling via the MRE11-RAD50-NBS1 complex.

BRIX1 ZNF609 ZFYVE16 KDM2A SEC31A CAMSAP1

6.50e-0547251638943005
Pubmed

BioID-based intact cell interactome of the Kv1.3 potassium channel identifies a Kv1.3-STAT3-p53 cellular signaling pathway.

MICALL1 EGFR ZFYVE16 SEC31A CAMSAP1 ATP2B1 EIF2AK3

7.48e-0570851739231216
Pubmed

A BioID-Derived Proximity Interactome for SARS-CoV-2 Proteins.

MICALL1 ZNF609 EGFR SEC31A HERC2 ATP2B1 SDR39U1

8.23e-0571951735337019
Pubmed

A Degradation Motif in STAU1 Defines a Novel Family of Proteins Involved in Inflammation.

MICALL1 ZNF609 TAF1C KDM2A DCLRE1A SEC31A CAMSAP1

8.60e-0572451736232890
Pubmed

Structure, expression, and genetic linkage of the mouse BCM1 (OX45 or Blast-1) antigen. Evidence for genetic duplication giving rise to the BCM1 region on mouse chromosome 1 and the CD2/LFA3 region on mouse chromosome 3.

FCGR2B CD48

9.42e-05105121693656
Pubmed

Diacylglycerol kinase delta regulates protein kinase C and epidermal growth factor receptor signaling.

EGFR DGKI

1.15e-041151217021016
Pubmed

Thbs1 regulates skeletal muscle mass in a TGFβ-Smad2/3-ATF4-dependent manner.

EIF2AK3 SMAD3

1.15e-041151238678560
Pubmed

Protein kinase C-alpha and protein kinase C-epsilon are required for Grb2-associated binder-1 tyrosine phosphorylation in response to platelet-derived growth factor.

EGFR PRKCE

1.38e-041251211940581
Pubmed

Genomewide screening for fusogenic human endogenous retrovirus envelopes identifies syncytin 2, a gene conserved on primate evolution.

ERVK-8 ERVK-9

1.38e-041251214557543
Pubmed

Viral protein engagement of GBF1 induces host cell vulnerability through synthetic lethality.

SEC31A ATP2B1 EIF2AK3

1.58e-047151336305789
Pubmed

EGF-stimulated signaling by means of PI3K, PLCgamma1, and PKC isozymes regulates branching morphogenesis of the fetal mouse submandibular gland.

EGFR PRKCE

1.63e-041351212761849
Pubmed

Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.

ALLC MORF4L2 KDM2A CAMSAP1 ATP2B1 EIF2AK3 SMAD3

2.43e-0485751725609649
Pubmed

Whole genome association scan for genetic polymorphisms influencing information processing speed.

CRTC3 TMEM245

2.50e-041651221130836
Pubmed

ADAM-TS5, ADAM-TS6, and ADAM-TS7, novel members of a new family of zinc metalloproteases. General features and genomic distribution of the ADAM-TS family.

FCGR2B CD48

2.83e-041751210464288
Pubmed

Construction of a physical map on mouse and human chromosome 1: comparison of 13 Mb of mouse and 11 Mb of human DNA.

FCGR2B CD48

3.18e-04185121301170
Pubmed

Chromosomal mapping of Adam9, Adam15 and Adam21.

FCGR2B CD48

3.18e-041851210842103
Pubmed

Expression patterns of transcribed human endogenous retrovirus HERV-K(HML-2) loci in human tissues and the need for a HERV Transcriptome Project.

ERVK-18 ERVK-9

3.18e-041851218664271
Pubmed

A revised nomenclature for transcribed human endogenous retroviral loci.

ERVK-8 ERVK-18 ERVK-9

3.62e-049451321542922
Pubmed

Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.

ZNF609 ZFYVE16 HERC2

4.87e-041045139205841
Pubmed

Systematic protein-protein interaction mapping for clinically relevant human GPCRs.

OSTC SLC41A3 SACS DCLRE1A HERC2 ATP2B1

5.31e-0469751628298427
Pubmed

BCOR modulates transcriptional activity of a subset of glucocorticoid receptor target genes involved in cell growth and mobility.

ZNF609 RADX

5.70e-042451233722704
Pubmed

Expressed sequence tag analysis of human RPE/choroid for the NEIBank Project: over 6000 non-redundant transcripts, novel genes and splice variants.

TAF1C SEC31A ATP2B2

6.87e-0411751312107410
Pubmed

A human MAP kinase interactome.

CRTC3 PRKCE KDM2A SEC31A HERC2

7.22e-0448651520936779
Pubmed

TRRAP is essential for regulating the accumulation of mutant and wild-type p53 in lymphoma.

ZFYVE16 SEC31A

7.78e-042851229653964
Pubmed

Biology, structure and mechanism of P-type ATPases.

ATP2B1 ATP2B2

8.35e-042951215071553
Pubmed

Potential genetic modifiers of the cystic fibrosis intestinal inflammatory phenotype on mouse chromosomes 1, 9, and 10.

FCGR2B CD48

9.54e-043151215921521
Pubmed

The recombinant congenic strains--a novel genetic tool applied to the study of colon tumor development in the mouse.

EGFR FCGR2B

1.15e-03345121686571
Pubmed

Maternal Transient Receptor Potential Vanilloid 6 (Trpv6) Is Involved In Offspring Bone Development.

ATP2B1 ATP2B2

1.43e-033851230786075
Pubmed

The Functional Proximal Proteome of Oncogenic Ras Includes mTORC2.

MICALL1 RHBDF1 EGFR CAMSAP1 ATP2B1

1.45e-0356951530639242
InteractionSLC45A2 interactions

EGFR ATP2B2 MINDY1

6.95e-0616483int:SLC45A2
Cytoband1q23.3

FCGR2C ERVK-18

1.38e-03495121q23.3
CytobandEnsembl 112 genes in cytogenetic band chr1q23

FCGR2C FCGR2B CD48

2.06e-03226513chr1q23
Cytoband2q35

ALLC USP37

3.53e-03795122q35
GeneFamilyATPases Ca2+ transporting

ATP2B1 ATP2B2

1.15e-0493321209
ToppCelldroplet-Heart-4Chambers-18m-Hematologic|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADGB SLC7A8 FCGR2B CD48

3.29e-05169484ea43002e74076aa03bf688c0a76c07117787d4b5
ToppCelldroplet-Heart-4Chambers-18m-Hematologic-leukocyte|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADGB SLC7A8 FCGR2B CD48

3.52e-0517248419ccac3d88382b8b2379d14525b2204c7407cb3b
ToppCellPBMC-Convalescent-Lymphocyte-B-B_cell-B_naive-B_naive-11|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

FCGR2B ANKAR PRKCE USP37

3.94e-051774843535575686c9700ab72700aae6f2070ebbb50044
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Intercalated_Cell_Type_B|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

EGFR SACS DGKI MINDY1

4.02e-0517848451d2188406f04329311b2efd1108fc36617a860e
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Intercalated_Cell_Type_B|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

EGFR SACS DGKI ATP2B2

4.20e-05180484cfc8bfbfd3617aabbb49f9730c29b673ca157e74
ToppCellControl|World / Disease state, Lineage and Cell class

ZFYVE16 DGKI USP37 ATP2B1

5.08e-05189484fb8dddd3b901081c6bb9ed6f32dafc5cce5f30be
ToppCell10x3'2.3-week_17-19-Lymphocytic_B-B_lineage-naive_B_cell|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

FCGR2B CD48 ATP2B1 SMAD3

5.29e-05191484a073d58154c801ec499fd969f42b7f1ee7f15d79
ToppCell3'-Parenchyma_lung-Epithelial-Epithelial_transtional-epithelial_cell_of_lung-Transitional_Club-AT2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ATP13A4 SELENBP1 ARHGAP40 SCUBE3

5.62e-051944845b29c843186c2394f5bec3b1d5ae284a0d931d85
ToppCell3'-Parenchyma_lung-Epithelial-Epithelial_transtional-epithelial_cell_of_lung|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ATP13A4 SELENBP1 ARHGAP40 SCUBE3

5.62e-051944848c6e5ba27a988e0cd6b8c25cb9a30a0da2b1f7f9
ToppCell3'-Parenchyma_lung-Epithelial-Epithelial_transtional-epithelial_cell_of_lung-Transitional_Club-AT2-Transitional_Club-AT2_L.0.4.1.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ATP13A4 SELENBP1 ARHGAP40 SCUBE3

5.62e-051944846e78e3046c5b172af92a84e25f982377a0aaac58
ToppCell3'-Parenchyma_lung-Epithelial-Epithelial_transtional|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ATP13A4 SELENBP1 ARHGAP40 SCUBE3

5.62e-05194484ebcf6c6d0eb20a5d422becf5a730089230c8ba9a
ToppCellMid-temporal_gyrus_(MTG)-Neuronal|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

DGKI PRKCE ATP2B1 ATP2B2

5.85e-05196484676c56b44ac29f7baecb62f49bb8597cc74c0a88
ToppCellParenchymal-NucSeq|Parenchymal / Cell types per location group and 10X technology with lineage, and cell group designations

ATP13A4 ZNF609 EGFR PRKCE

6.08e-051984841996373bdccc55aac347d349bd22f6aad6d0c668
ToppCellSomatosensory_Cortex_(S1)-Neuronal|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

DGKI PRKCE ATP2B1 ATP2B2

6.08e-05198484c01091ef18e096d792ea2a7a715764a5b215355f
ToppCellprimary_auditory_cortex_(A1C)-Neuronal|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

DGKI PRKCE ATP2B1 ATP2B2

6.08e-051984846d18b45eda4014759e6dd282d78ffd28df8a6044
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

DGKI PRKCE ATP2B1 ATP2B2

6.08e-051984848ab40fae14fe02e39bc8c8da187a5cd60c787643
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

DGKI PRKCE ATP2B1 ATP2B2

6.08e-051984844ca5ff320905ab4ff60ed90a5522227c782142a6
ToppCellproximal-Epithelial-Club|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

ATP13A4 SELENBP1 ARHGAP40 SCUBE3

6.20e-0519948499d23c0373f1ae5267bb3e51c5c88c8f52559ae4
ToppCellproximal-Epithelial-Club-3|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

ATP13A4 SELENBP1 ARHGAP40 SCUBE3

6.20e-05199484e8b3b003b581aa001c23440a03d80da9560129b3
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-Mono-Mono_anti-infl-G|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

SLC7A8 FCGR2C FCGR2B ATP2B1

6.20e-05199484667b8b47a5b388506e3177b46747267fad8024f6
ToppCellproximal-3-Epithelial-Club|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

ATP13A4 SELENBP1 ARHGAP40 SCUBE3

6.20e-0519948477dc850032746339557c844cfc1f93eb27210f22
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW23-Macroglial|GW23 / Sample Type, Dataset, Time_group, and Cell type.

ATP13A4 SELENBP1 EGFR RADX

6.33e-0520048470c2e577efb6b6fe8f9d970d7ecc470788efb85b
ToppCellNeuronal|World / cells hierarchy compared to all cells using T-Statistic

DGKI PRKCE ATP2B1 ATP2B2

6.33e-0520048448d801219bc771d6c7e151dc88ca4c179988de85
DrugCetuximab

FCGR2C EGFR FCGR2B

1.91e-0612483DB00002
DrugTrastuzumab

FCGR2C EGFR FCGR2B

2.48e-0613483DB00072
DrugTriflusal [322-79-2]; Down 200; 16.2uM; MCF7; HT_HG-U133A

SLC7A8 ZFYVE16 DCLRE1A CAMSAP1 MINDY1 SMAD3

3.32e-061954867451_DN
Drugvanadyl

FCGR2C RHBDF1 EGFR FCGR2B PRKCE ATP2B1 ATP2B2

3.47e-06307487CID000061671
DrugAC1NS1NG

RHBDF1 EGFR PRKCE ATP2B1 ATP2B2

1.43e-05147485CID005327099
DrugFura-2AM

SACS PRKCE ATP2B1 ATP2B2

2.33e-0579484CID000105091
DrugPD168393

RHBDF1 EGFR

2.60e-054482CID000004708
Drugmyo-inositol

FCGR2C RHBDF1 EGFR FCGR2B DGKI PRKCE ATP2B1 ATP2B2 EIF2AK3

4.25e-05811489CID000000892
DrugMDL 20,610

FCGR2C FCGR2B

4.33e-055482CID000128209
DrugRG 14921

RHBDF1 EGFR

4.33e-055482CID000197517
Drug6-quinolinecarbaldehyde

RHBDF1 EGFR

4.33e-055482CID000765653
DrugClemastine fumarate [14976-57-9]; Up 200; 8.6uM; HL60; HT_HG-U133A

MICALL1 SLC7A8 ZNF609 CAMSAP1 SMAD3

5.29e-051934852412_UP
DrugNalbuphine hydrochloride [23277-43-2]; Up 200; 10.2uM; HL60; HG-U133A

MICALL1 HUS1 TAF1C PRKCE KDM2A

5.70e-051964851379_UP
DrugCefotaxime sodium salt [64485-93-4]; Up 200; 8.4uM; MCF7; HT_HG-U133A

MICALL1 ZNF609 HUS1 ATP2B2 SMAD3

5.70e-051964857186_UP
Drug3-Acetamidocoumarin [779-30-6]; Down 200; 19.6uM; MCF7; HT_HG-U133A

SLC7A8 ZNF609 HUS1 TAF1C SMAD3

5.83e-051974857361_DN
DrugTalampicillin hydrochloride [39878-70-1]; Down 200; 7.8uM; MCF7; HT_HG-U133A

SLC41A3 EGFR TAF1C MINDY1 SMAD3

5.83e-051974853515_DN
DrugApomorphine hydrochloride hemihydrate [41372-20-7]; Up 200; 6.4uM; PC3; HT_HG-U133A

ADGB ZNF609 TAF1C DGKI ATP2B2

5.83e-051974856683_UP
DrugEthambutol dihydrochloride [1070-11-7]; Down 200; 14.4uM; PC3; HG-U133A

MICALL1 ZNF609 RHBDF1 SELENBP1 ATP2B1

5.98e-051984851900_DN
DrugCyproheptadine hydrochloride [969-33-5]; Up 200; 12.4uM; PC3; HG-U133A

MICALL1 ZNF609 CAMSAP1 ATP2B1 EIF2AK3

5.98e-051984851938_UP
DrugAC1L1KQK

RHBDF1 EGFR PRKCE

5.98e-0536483CID000005612
DrugCephalosporanic acid, 7-amino [957-68-6]; Up 200; 14.6uM; HL60; HT_HG-U133A

ZNF609 HUS1 ZFYVE16 CAMSAP1 SMAD3

6.12e-051994851322_UP
DrugTAN-1030A

FCGR2C FCGR2B

6.49e-056482CID009576886
DrugSnCe6

RHBDF1 EGFR

6.49e-056482CID000164259
DrugCochliobolic acid

RHBDF1 EGFR

6.49e-056482CID006450172
Drugureidoglycolate

ALLC CD48

6.49e-056482CID000000336
Drugdiethyl ester

RHBDF1 EGFR

6.49e-056482CID000264327
DrugSSFSB

RHBDF1 EGFR

9.08e-057482CID003035734
DrugRG 14467

RHBDF1 EGFR

9.08e-057482CID000132069
DrugTAN-999

FCGR2C FCGR2B

9.08e-057482CID000130283
DrugAC1MHTIN

FCGR2C FCGR2B

9.08e-057482CID003011133
Drugtyrphostin 23

FCGR2C EGFR FCGR2B PRKCE

1.05e-04116484CID000002052
DrugI50 - 9

RHBDF1 EGFR

1.21e-048482CID000083651
DrugIntravenous Immunoglobulin

FCGR2C FCGR2B

1.21e-048482DB00028
Drugagelasine B

PRKCE ATP2B1 ATP2B2

1.25e-0446483CID006439899
DrugAC1L1KC5

RHBDF1 EGFR SACS PRKCE ATP2B1 ATP2B2 EIF2AK3

1.30e-04541487CID000005428
DrugAC1NSK5W

FCGR2C FCGR2B

1.55e-049482CID005311182
DrugR 8231

ATP2B1 ATP2B2

1.55e-049482CID003084926
DrugD07907

RHBDF1 EGFR EIF2AK3

1.81e-0452483CID011954378
Drugtricyclohexyltin chloride

ATP2B1 ATP2B2

1.94e-0410482CID000076539
DrugPalivizumab

FCGR2C FCGR2B

1.94e-0410482DB00110
DrugDenny-Jaffe reagent

FCGR2C FCGR2B

1.94e-0410482CID003035979
DrugH 661

RHBDF1 EGFR

1.94e-0410482CID003056529
Drugtetrachloro-

SUPV3L1 PRKCE

1.94e-0410482CID005326109
Drug1sqc

ATP2B1 ATP2B2

1.94e-0410482CID000444279
DrugBE-23372M

RHBDF1 EGFR

2.36e-0411482CID005311105
DrugBevacizumab

FCGR2C FCGR2B

2.36e-0411482DB00112
DrugTositumomab

FCGR2C FCGR2B

2.36e-0411482DB00081
DrugAlemtuzumab

FCGR2C FCGR2B

2.36e-0411482DB00087
DrugEfalizumab

FCGR2C FCGR2B

2.36e-0411482DB00095
DrugAlefacept

FCGR2C FCGR2B

2.36e-0411482DB00092
Drug2,5-dimethylquinone

ATP2B1 ATP2B2

2.36e-0411482CID000008718
Drug4,5-dianilinophthalimide

RHBDF1 EGFR

2.36e-0411482CID000001697
Drugpersulfate

ATP2B1 ATP2B2

2.36e-0411482CID000024413
DrugTAPI-1

RHBDF1 EGFR PRKCE

2.38e-0457483CID009827273
DrugAC1NSKPI

ATP2B1 ATP2B2 EIF2AK3

2.38e-0457483CID005311482
DrugMelphalan

RADX B3GNT2 ANKAR ATP2B1 SMAD3

2.82e-04276485ctd:D008558
DrugDaclizumab

FCGR2C FCGR2B

2.83e-0412482DB00111
DrugNatalizumab

FCGR2C FCGR2B

2.83e-0412482DB00108
DrugRituximab

FCGR2C FCGR2B

2.83e-0412482DB00073
DrugIbritumomab

FCGR2C FCGR2B

2.83e-0412482DB00078
DrugAdalimumab

FCGR2C FCGR2B

2.83e-0412482DB00051
DrugGemtuzumab ozogamicin

FCGR2C FCGR2B

2.83e-0412482DB00056
Drug1vyq

ATP2B1 ATP2B2

2.83e-0412482CID004369390
DrugRo 46861

ATP2B1 ATP2B2

2.83e-0412482CID000003128
Drug2nq6

RHBDF1 EGFR

3.34e-0413482CID011809364
DrugS-dC28

EGFR PRKCE

3.34e-0413482CID000159480
DrugBasiliximab

FCGR2C FCGR2B

3.34e-0413482DB00074
DrugAC1L9JR2

RHBDF1 EGFR

3.34e-0413482CID000446506
Drug8-hydroxycoumarin

ATP2B1 ATP2B2

3.34e-0413482CID000122783
Drugfura 2

PRKCE ATP2B1 ATP2B2

3.50e-0465483CID000057054
Diseasebirth weight, parental genotype effect measurement

FCGR2C CRTC3 FCGR2B SUPV3L1 SMAD3

1.36e-05192475EFO_0004344, EFO_0005939
DiseaseHailey-Hailey disease (implicated_via_orthology)

ATP2B1 ATP2B2

3.71e-056472DOID:0050429 (implicated_via_orthology)
DiseaseColorectal Neoplasms

SELENBP1 EGFR PRKCE KDM2A SMAD3

7.81e-05277475C0009404
Diseaseplexin-B2 measurement

FCGR2C FCGR2B

8.88e-059472EFO_0021867
Diseasemalaria (implicated_via_orthology)

FCGR2C FCGR2B

8.88e-059472DOID:12365 (implicated_via_orthology)
Diseasecentral nervous system cancer, glioblastoma multiforme

RHBDF1 EGFR

2.23e-0414472EFO_0000326, EFO_0000519
Diseaselow affinity immunoglobulin gamma Fc region receptor II-a measurement

FCGR2C FCGR2B

3.33e-0417472EFO_0021969
Diseasecolorectal cancer

CRTC3 XRRA1 DCLRE1A HERC2 CAMSAP1 SMAD3

3.78e-04604476MONDO_0005575
Diseaselow affinity immunoglobulin gamma Fc region receptor II-b measurement

FCGR2C FCGR2B

7.28e-0425472EFO_0021970
DiseaseColorectal Carcinoma

SELENBP1 EGFR SACS PRKCE KDM2A SMAD3

8.31e-04702476C0009402
Diseaseprogressive supranuclear palsy

ATP2B2 EIF2AK3

1.12e-0331472MONDO_0019037
Diseasesystemic lupus erythematosus (implicated_via_orthology)

FCGR2C FCGR2B

2.15e-0343472DOID:9074 (implicated_via_orthology)
Diseaselung non-small cell carcinoma (is_marker_for)

EGFR KDM2A SMAD3

2.49e-03169473DOID:3908 (is_marker_for)
Diseaseserum non-albumin protein measurement

SLC7A8 FCGR2C FCGR2B SMAD3

2.60e-03361474EFO_0004568
Diseasefactor VII activating protease measurement

ZNF609 DCLRE1A

3.49e-0355472EFO_0009368
Diseasepolyp of colon

XRRA1 SMAD3

3.62e-0356472MONDO_0021400
Diseaseosteoarthritis, hip, osteoarthritis, knee

DGKI SMAD3

4.42e-0362472EFO_0004616, EFO_1000786
Diseaseattention deficit hyperactivity disorder, schizophrenia

DGKI MINDY1

4.70e-0364472EFO_0003888, MONDO_0005090

Protein segments in the cluster

PeptideGeneStartEntry
NAIIPLPTIKWKPLI

EIF2AK3

421

Q9NZJ5
KWKPLLPVTKLSPNQ

ALLC

316

Q8N6M5
LPPWKLIRQKKETVI

ADGB

476

Q8N7X0
VTPIWKLLIKEVLNP

ATP13A4

191

Q4VNC1
APPKAVLKLEPQWIN

FCGR2B

46

P31994
IEIQWVKPEPKVDLK

BRIX1

316

Q8TDN6
LWQPKRPAVPKKAQT

CAMSAP1

1586

Q5T5Y3
PPKKPKTFLQLVWEA

ATP2B1

91

P20020
FIPPKKPKTFLQLVW

ATP2B2

86

Q01814
VLECPNLKLKKPPWL

OSTC

11

Q9NRP0
WKKPDIPRPIKINLL

SLC7A8

411

Q9UHI5
IIPEKQVKPEWRLPK

RADX

341

Q6NSI4
IIKLNIPELPVWKTL

ANKAR

691

Q7Z5J8
PIAIKSPKDKWQPLL

HERC2

1596

O95714
IDWVLLEQKKIKPPF

PRKCE

671

Q02156
APPKAVLKLEPQWIN

FCGR2C

46

P31995
LFLQWKVKLPPQKEV

MINDY1

146

Q8N5J2
VKVKIPEELKPWLVE

MORF4L2

121

Q15014
WITLVQAEPKKKPAP

MICALL1

371

Q8N3F8
PKPIPLTWKTEKLVW

ERVK-18

21

Q9QC07
WIPEGEKVKIPVAIK

EGFR

731

P00533
VPIVQWPKRDKLKFP

KDM2A

511

Q9Y2K7
AVIVPPTWIIKVKKP

DGKI

316

O75912
PKPLPKQLWETKEIQ

CRTC3

221

Q6UUV7
KRFVQWLKPQKIIPT

DCLRE1A

1001

Q6PJP8
KAITKAPQPPKAWVL

SDR39U1

91

Q9NRG7
WKIKLQVLDPVPKPV

CD48

121

P09326
IWNINPPPKRKILIV

SCUBE3

831

Q8IX30
LKKIKWVPACKERPP

SACS

1151

Q9NZJ4
KKEDIVIPWSLPLLP

C9orf85

101

Q96MD7
SIPWIPEPQVIKLSK

CFAP47

2256

Q6ZTR5
KALLKVPLAPPVWTA

TAF1C

641

Q15572
KVIPRKLWKDLQEPV

HUS1

136

O60921
SLQRKKPPWLKLDIP

RHBDF1

11

Q96CC6
IQVPPKKVKGWLLPE

SELENBP1

291

Q13228
PVWVLIAKQSPPIVK

SLC41A3

266

Q96GZ6
PPIVKILKFGWFPII

SLC41A3

276

Q96GZ6
YIKWPLLPPKNIKDL

SUPV3L1

611

Q8IYB8
IEPPKPIPLTWKTEK

ERVK-9

941

P63128
VIIPKEKFWKISTPP

B3GNT2

41

Q9NY97
KQPLEKFELKPIPWA

NLRP9

31

Q7RTR0
VAKIQVVWPIKDPLK

ARHGAP40

521

Q5TG30
VVWPIKDPLKVPLTP

ARHGAP40

526

Q5TG30
PFTPPIVKRLLGWKK

SMAD3

6

P84022
PKPIPLTWKTEKLVW

ERVK-8

21

P63133
LKEEWKQKPSIPPTL

ZNF609

1036

O15014
QLLPVPIAVWILKKL

TMEM245

376

Q9H330
KQGIPWKKIPLNALI

USP37

371

Q86T82
QHSIVLPLKKPPKWI

SEC31A

376

O94979
KEKTPVPVPEKQISW

WDR87

2401

Q6ZQQ6
VIPPIKAKEKESWPK

WDR87

2601

Q6ZQQ6
WKVKSEIPKVPKQPL

XRRA1

451

Q6P2D8
ILIQKLEIPWAKVFP

ZFYVE16

1176

Q7Z3T8
IRVKWPVKPFQLKEE

ZNF541

1321

Q9H0D2