Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionenzyme regulator activity

PRPSAP2 RAPGEF6 PPP2R5E CSN2 RAPGEF5 TBC1D24 CCNB1 RAPGEFL1 RAPGEF4

7.30e-041418369GO:0030234
GeneOntologyMolecularFunctionguanyl-nucleotide exchange factor activity

RAPGEF6 RAPGEF5 RAPGEFL1 RAPGEF4

7.69e-04231364GO:0005085
GeneOntologyMolecularFunctionGTP-dependent protein binding

RAPGEF6 RAPGEF5

8.51e-0424362GO:0030742
GeneOntologyMolecularFunctionGTPase regulator activity

RAPGEF6 RAPGEF5 TBC1D24 RAPGEFL1 RAPGEF4

2.04e-03507365GO:0030695
GeneOntologyMolecularFunctionnucleoside-triphosphatase regulator activity

RAPGEF6 RAPGEF5 TBC1D24 RAPGEFL1 RAPGEF4

2.04e-03507365GO:0060589
GeneOntologyBiologicalProcessperipheral nervous system myelin formation

ITGB4 PRX

1.67e-054352GO:0032290
GeneOntologyBiologicalProcessRas protein signal transduction

RAPGEF6 RAPGEF5 RAPGEFL1 RAPGEF4

6.38e-05128354GO:0007265
GeneOntologyCellularComponentsperm cytoplasmic droplet

ROPN1B ROPN1

2.87e-055362GO:0097598
HumanPhenoAbnormality of dental eruption

GHR MIA3 KMT2D ADNP SMCHD1 TBC1D24

1.33e-05240136HP:0006292
DomainRASGEF_CAT

RAPGEF6 RAPGEF5 RAPGEFL1 RAPGEF4

2.99e-0729374PS50009
DomainRasGEF

RAPGEF6 RAPGEF5 RAPGEFL1 RAPGEF4

3.44e-0730374PF00617
Domain-

RAPGEF6 RAPGEF5 RAPGEFL1 RAPGEF4

3.44e-07303741.10.840.10
DomainRas_GEF_dom

RAPGEF6 RAPGEF5 RAPGEFL1 RAPGEF4

3.44e-0730374IPR023578
DomainRASGEF_cat_dom

RAPGEF6 RAPGEF5 RAPGEFL1 RAPGEF4

3.44e-0730374IPR001895
DomainRasGEF

RAPGEF6 RAPGEF5 RAPGEFL1 RAPGEF4

3.44e-0730374SM00147
DomainRasGEFN

RAPGEF6 RAPGEF5 RAPGEF4

7.97e-0620373SM00229
DomainRasGEF_N

RAPGEF6 RAPGEF5 RAPGEF4

9.29e-0621373PF00618
DomainRASGEF_NTER

RAPGEF6 RAPGEF5 RAPGEF4

1.07e-0522373PS50212
DomainRas-like_Gua-exchang_fac_N

RAPGEF6 RAPGEF5 RAPGEF4

1.07e-0522373IPR000651
DomainRASGEF

RAPGEF5 RAPGEFL1 RAPGEF4

1.80e-0526373PS00720
DomainRas_G-nucl-exch_fac_CS

RAPGEF5 RAPGEF4

3.42e-0414372IPR019804
DomaincAMP_dep_PK_reg_su_I/II_a/b

ROPN1B ROPN1

3.95e-0415372IPR003117
DomaincNMP

RAPGEF6 RAPGEF4

2.06e-0334372SM00100
DomaincNMP_binding

RAPGEF6 RAPGEF4

2.06e-0334372PF00027
DomaincNMP-bd_dom

RAPGEF6 RAPGEF4

2.18e-0335372IPR000595
DomainCNMP_BINDING_3

RAPGEF6 RAPGEF4

2.18e-0335372PS50042
DomainRA

RAPGEF6 RAPGEF4

2.31e-0336372PF00788
DomaincNMP-bd-like

RAPGEF6 RAPGEF4

2.57e-0338372IPR018490
DomainRA_dom

RAPGEF6 RAPGEF4

2.84e-0340372IPR000159
Domain-

RAPGEF6 RAPGEF4

4.07e-03483722.60.120.10
DomainRmlC-like_jellyroll

RAPGEF6 RAPGEF4

4.58e-0351372IPR014710
DomainUbiquitin-rel_dom

RAPGEF5 RAPGEFL1 RAPGEF4

5.71e-03184373IPR029071
DomainPHD

KMT2D PHF3

9.68e-0375372PF00628
DomainZnf_PHD-finger

KMT2D PHF3

1.07e-0279372IPR019787
Pubmed

Loss of R2D2 proteins ROPN1 and ROPN1L causes defects in murine sperm motility, phosphorylation, and fibrous sheath integrity.

ROPN1B ROPN1

3.48e-06338223303679
Pubmed

Loss of ASP but not ROPN1 reduces mammalian ciliary motility.

ROPN1B ROPN1

3.48e-06338222021175
Pubmed

FSCB phosphorylation regulates mouse spermatozoa capacitation through suppressing SUMOylation of ROPN1/ROPN1L.

ROPN1B ROPN1

6.96e-06438227398160
Pubmed

Ropporin, a sperm-specific binding protein of rhophilin, that is localized in the fibrous sheath of sperm flagella.

ROPN1B ROPN1

6.96e-06438210591629
Pubmed

CABYR isoforms expressed in late steps of spermiogenesis bind with AKAPs and ropporin in mouse sperm fibrous sheath.

ROPN1B ROPN1

1.16e-05538220731842
Pubmed

Mechanism of regulation of the Epac family of cAMP-dependent RapGEFs.

RAPGEF5 RAPGEF4

1.16e-05538210777494
Pubmed

Identification of sperm-specific proteins that interact with A-kinase anchoring proteins in a manner similar to the type II regulatory subunit of PKA.

ROPN1B ROPN1

1.74e-05638211278869
Pubmed

Novel Rap1 dominant-negative mutants interfere selectively with C3G and Epac.

RAPGEF5 RAPGEF4

1.74e-05638215856025
Pubmed

Identification of guanine nucleotide exchange factors (GEFs) for the Rap1 GTPase. Regulation of MR-GEF by M-Ras-GTP interaction.

RAPGEF5 RAPGEFL1

2.43e-05738210934204
Pubmed

SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.

KMT2D RAPGEF6 ADNP UBN2 PHF3 SMCHD1

2.71e-0554938638280479
Pubmed

FSCB, a novel protein kinase A-phosphorylated calcium-binding protein, is a CABYR-binding partner involved in late steps of fibrous sheath biogenesis.

ROPN1B ROPN1

4.16e-05938217855365
Pubmed

CFAP61 is required for sperm flagellum formation and male fertility in human and mouse.

ROPN1B ROPN1

5.20e-051038234792097
Pubmed

Linkage mapping of 40 randomly isolated liver cDNA clones in the mouse.

GHR FGA IL1A

8.01e-05763838288233
Pubmed

Agonist-specific Protein Interactomes of Glucocorticoid and Androgen Receptor as Revealed by Proximity Mapping.

KMT2D DBT SMCHD1

8.65e-057838328611094
Pubmed

Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain.

MIA3 RAPGEF5 PHF3

1.04e-04833839039502
Pubmed

Whole genome sequencing resource identifies 18 new candidate genes for autism spectrum disorder.

UBN2 PHF3

1.05e-041438228263302
Pubmed

Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.

SMG9 MIA3 ADNP LEMD3 PHF3

1.13e-0444038534244565
Pubmed

The ubiquitin ligase Uhrf2 is a master regulator of cholesterol biosynthesis and is essential for liver regeneration.

ADNP PHF3 SMCHD1

1.16e-048638337253089
Pubmed

Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.

TICRR MIA3 RAPGEF6 PPP2R5E UBN2 RAPGEF5 ITGB4

1.52e-04108438711544199
Pubmed

The contribution of de novo coding mutations to autism spectrum disorder.

UBN2 PHF3

1.76e-041838225363768
Pubmed

Proximity-dependent Mapping of the Androgen Receptor Identifies Kruppel-like Factor 4 as a Functional Partner.

KMT2D UBN2 PHF3 SMCHD1

2.07e-0426838433640491
Pubmed

The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery.

OMA1 MIA3 MAN1A2 PPP2R5E LEMD3 PHF3 TBC1D24

2.87e-04120338729180619
Pubmed

HIV-1 Vpr induces cell cycle G2 arrest in fission yeast (Schizosaccharomyces pombe) through a pathway involving regulatory and catalytic subunits of PP2A and acting on both Wee1 and Cdc25.

PPP2R5E CCNB1

3.72e-042638211531413
Pubmed

Serotonin Regulates Adult β-Cell Mass by Stimulating Perinatal β-Cell Proliferation.

GHR CCNB1

4.01e-042738231806625
Pubmed

H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.

TICRR KMT2D ADNP UBN2 LEMD3 PHF3 SMCHD1

4.46e-04129438730804502
Pubmed

Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening.

GHR ADNP SNX7 PRX

4.50e-0432938417474147
Pubmed

High-density SNP association study and copy number variation analysis of the AUTS1 and AUTS5 loci implicate the IMMP2L-DOCK4 gene region in autism susceptibility.

MFSD6 RAPGEF4

4.96e-043038219401682
Pubmed

The in vivo Interaction Landscape of Histones H3.1 and H3.3.

ADNP UBN2 CSN2 PHF3 SMCHD1

5.00e-0460838536089195
Pubmed

Transcription factor Foxp3 and its protein partners form a complex regulatory network.

DBT PHF3 SMCHD1 CCNB1

6.99e-0437038422922362
Pubmed

Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network.

GHR FGA IL1A CCNB1

7.06e-0437138425241761
Pubmed

Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy.

PRPSAP2 ADNP ITGB4 CCNB1

9.43e-0440138425852190
Pubmed

FBXL13 directs the proteolysis of CEP192 to regulate centrosome homeostasis and cell migration.

ADNP RAPGEF4

9.74e-044238229348145
InteractionLIMS2 interactions

RAPGEF5 MTUS2 RAPGEFL1

1.96e-0528383int:LIMS2
InteractionROPN1B interactions

ROPN1B ROPN1

3.45e-055382int:ROPN1B
GeneFamilyPHD finger proteins

KMT2D PHF3

4.39e-039020288
GeneFamilyPDZ domain containing

RAPGEF6 PRX

1.21e-021522021220
GeneFamilyFibronectin type III domain containing

GHR ITGB4

1.33e-02160202555
GeneFamilyEndogenous ligands

FGA IL1A

2.78e-02237202542
CoexpressionPRC1_BMI_UP.V1_DN

FGA KMT2D ADAMTS7 RAPGEF5 MFSD6

7.26e-06187385M2730
ToppCelldroplet-Pancreas-Endocrine-18m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GHR MIA3 UBN2 RAPGEF4

2.12e-051923841304e69c92cef3bd8c82e3c035a7562f5440139a
ToppCellFetal_29-31_weeks-Endothelial-endothelial_cell_of_vein|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

RAPGEF5 ITGB4 PRX RAPGEF4

2.21e-05194384fc2e0081005c0c496e41197a2d06e4a37708221f
ToppCellfacs-Lung-nan-3m-Endothelial-endothelial_cell_of_lung|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GHR RAPGEF5 PRX RAPGEF4

2.21e-05194384f159ef8541d75a4e98468947f231bb463bec922c
ToppCell368C-Endothelial_cells|368C / Donor, Lineage, Cell class and subclass (all cells)

RAPGEF5 ITGB4 PRX RAPGEF4

2.39e-051983849a2c2201baee51581733e183065298a97eba4553
ToppCell(09)_Interm._secr.>cil.-(2)_GFP_FOXI1|(09)_Interm._secr.>cil. / shred by cell type by condition

MAN1A2 PPP2R5E ADNP PHF3

2.44e-05199384fc680f85ebd3bab4c72876a19a461b0afb5f51ce
ToppCellLPS_IL1RA_TNF-Endothelial-Endothelial|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

RAPGEF5 SMCHD1 PRX RAPGEF4

2.48e-05200384a1fa6bae5a688faf488d6925cd3fad725dfa916b
ToppCellLPS_IL1RA_TNF-Endothelial|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

RAPGEF5 SMCHD1 PRX RAPGEF4

2.48e-05200384d01cec331be3b03cef80e9536fc531285bcf00f6
ToppCellLPS_IL1RA_TNF-Endothelial-Endothelial-Activated_Alv_Cap|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

RAPGEF5 SMCHD1 PRX RAPGEF4

2.48e-0520038489821a264e872ed53e08e9d3609d5cc5c314503e
ToppCellPND28-Immune-Immune_Myeloid-DC-cDC1-cDC1_mature|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

TICRR SEPTIN3 RAPGEFL1

3.46e-0416138376c993a4533362db2250c88b3ee3ede55362d54e
ToppCellPND01-03-samps|World / Age Group, Lineage, Cell class and subclass

IL1A RAPGEF5 PRX

3.46e-041613831973b112d8d67aacc02751797d0148e7b53bfa66
ToppCellTCGA-Brain-Primary_Tumor-Low_Grade_Glioma-Astrocytoma|TCGA-Brain / Sample_Type by Project: Shred V9

OMA1 DBT ITGB4

3.52e-04162383810881210e015c788814e4fe8d7a24c929cf2621
ToppCellPND28-Immune-Immune_Myeloid-DC-cDC1|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

TICRR SEPTIN3 RAPGEFL1

3.65e-041643835638d95c7cc5e59c4a7bda30268a904a01861a5f
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Degenerative_Fibroblast-Degenerative_Fibroblast_104|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

UBN2 HEATR4 RAPGEFL1

3.78e-04166383c11dcf9705b85ac3da6ae86358f5ffd64ae8327e
ToppCelldroplet-Pancreas-Exocrine-24m-Epithelial-pancreatic_acinar_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DBT RAPGEF5 CCNB1

3.85e-041673833c06894fc6177f3c204094719904da42f08b9af8
ToppCelldroplet-Kidney-KIDNEY-30m-Epithelial-brush_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GHR FGA SNX7

3.92e-04168383b14fd50232887b6dca1f39014d43c6f66e5c3b5c
ToppCell390C-Myeloid-Dendritic-cDC_proliferating_1|390C / Donor, Lineage, Cell class and subclass (all cells)

SEPTIN3 IL1A CCNB1

3.92e-041683832082b15fc7935a211f1c61506b305af5501a21ad
ToppCellfacs-Trachea-nan-24m-Mesenchymal-smooth_muscle_cell_of_trachea|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RAPGEF5 NSUN7 PRX

3.92e-041683836c7b490b6c844d0ea4c07edfc24c02284f9533c4
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Glomerular_Capillary_Endothelial_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

RAPGEF5 PRX RAPGEF4

3.99e-04169383987ff79ad563825dd9877ea8ccb536758f8c6700
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-papillary_tips_cell-Papillary_Tip_Epithelial_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

IL1A ITGB4 RAPGEFL1

4.13e-0417138359b9dbaa05b6e5740edc633c9ce1181565550d5b
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-papillary_tips_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

IL1A ITGB4 RAPGEFL1

4.13e-04171383a5b9dd2b6a54db7962beeb5a9ceb9dacfb613fa7
ToppCellNS-critical-d_16-33-Epithelial-Basal|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

CSN2 CRAT RAPGEFL1

4.27e-041733833d3afc9ab234eaabf5b9bff455406231cd54ded6
ToppCellPND10-Immune-Immune_Myeloid-Monocytic-Macrophage-IM-IM_G2M|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

TICRR IL1A CCNB1

4.27e-0417338312c6875f881cb0fbff09d753b53c1cce7a95527f
ToppCell5'-Adult-LargeIntestine-Hematopoietic-B_cells-Cycling_B_cell|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PRPSAP2 RAPGEF5 CCNB1

4.27e-04173383b7e0193fd4983cb38d1bee441f608f73ee8743b9
ToppCelldroplet-Lung-18m-Hematologic-myeloid-myeloid_dendritic_cell-proliferating_dendritic|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

TICRR SEPTIN3 CCNB1

4.41e-04175383a6913f992a1ea20b43e5adeca3ede3a6fda820ad
ToppCellfacs-Brain_Non-Myeloid-Cerebellum-3m-Neuronal-interneuron|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SEPTIN3 LEMD3 RAPGEF4

4.41e-0417538365571d775d26a40e979dbf290a8e4320c0d9fb3f
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell_cycling-Cycling_Distal_Convoluted_Tubule_Cell_G2M|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

TICRR IL1A CCNB1

4.41e-04175383876cea684faf42ff3eb4623ad6d7a1fb1276ee02
ToppCelldroplet-Lung-3m-Hematologic-myeloid-myeloid_dendritic_cell-proliferating_dendritic|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

TICRR SEPTIN3 CCNB1

4.49e-04176383581045e61cdcdfa85701343d1a7c0a72a36606a7
ToppCellwk_15-18-Epithelial-Proximal_epithelial-SMG_basal_2|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

ROPN1B ITGB4 ROPN1

4.49e-04176383045b12c90f7dd49a9778dadcdf8f18125b380531
ToppCellPND10-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP2-CAP2_G2M|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

RAPGEF5 PRX CCNB1

4.72e-04179383327cc39161741ddbc4e8d45b9b3d30b3ce508929
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell_cycling|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

TICRR IL1A CCNB1

4.79e-04180383401df9cddcbca1eb8f0d2687bcacd98e95dc1493
ToppCell368C-Endothelial_cells-Endothelial-E|368C / Donor, Lineage, Cell class and subclass (all cells)

RAPGEF5 PRX RAPGEF4

4.79e-041803838ab16a0b9053bffc07b569a4f9e71749f56dde7e
ToppCellFetal_29-31_weeks-Endothelial-alveolar_capillary_endothelial_cell_(Cap2;_aerocyte)-D088|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

RAPGEF5 PRX RAPGEF4

4.79e-04180383d8ef44710a77ad0fc03243428e5e1dc4d41200cb
ToppCell368C-Endothelial_cells-Endothelial-E-|368C / Donor, Lineage, Cell class and subclass (all cells)

RAPGEF5 PRX RAPGEF4

4.79e-04180383394cd465b88429b70eebb2957480dffcbc51cfe7
ToppCellLPS-antiTNF-Endothelial-Endothelial-Alv_Cap|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

RAPGEF5 PRX RAPGEF4

4.79e-0418038330cf3c7ee29694eaccb89bf8053a82037d5c9f1d
ToppCellCOVID-19-Endothelial_cells-Capillary_endothelial_cells|COVID-19 / group, cell type (main and fine annotations)

RAPGEF5 PRX RAPGEF4

4.87e-04181383c5f9c92af1384d9089c65afdf41c6feb8345a3ae
ToppCellFetal_29-31_weeks-Endothelial-endothelial_cell_of_vein-D062|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

RAPGEF5 PRX RAPGEF4

4.87e-041813832c660fcf0404c155955b67ab2958d6e6b0e30024
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-papillary_tips_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ITGB4 MTUS2 RAPGEFL1

4.95e-04182383678eadd57e7e830fc2bf9fd35616d3badce01705
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell_cycling-Cycling_Connecting_Tubule_Cell_G2M|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

TICRR IL1A CCNB1

4.95e-04182383336cd05e46a741185ce3c59ee67a4b07fa6a5101
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-papillary_tips_cell-Papillary_Tip_Epithelial_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ITGB4 MTUS2 RAPGEFL1

4.95e-041823838d1229fa5aa6e2e38f2ac6fe4f4dc89752fe9344
ToppCellE18.5-samps-Endothelial-Mature_fetal_endothelial-endothelial_cells_A|E18.5-samps / Age Group, Lineage, Cell class and subclass

RAPGEF5 PRX CCNB1

4.95e-04182383ea4f6c8f600ffe9f8e0609637b3371a5ac48ca03
ToppCellAdult-Endothelial-alveolar_capillary_endothelial_cell_(Cap2;_aerocyte)-D175|Adult / Lineage, Cell type, age group and donor

RAPGEF5 PRX RAPGEF4

4.95e-041823838b4a07ebd7a133a33ef333cfa29d12c4f3d4d9ac
ToppCelldroplet-Limb_Muscle-Pre-Sort-18m-Macroglial-nan|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FGA SEPTIN3 PRX

4.95e-04182383c00e503f442d44fbae73c5e2dc85be69e294e67a
ToppCellfacs-Thymus-nan-3m-Lymphocytic-DN4_thymocyte|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FGA RAPGEF6 ADNP

5.19e-04185383a2cae8c657e4f4d121476798e424876f7e247973
ToppCellfacs-Thymus-nan-3m-Lymphocytic-DN4_thymocyte|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FGA RAPGEF6 ADNP

5.19e-04185383d50406a9a5b8d75110ba5985741aa2293950c543
ToppCellwk_15-18-Endothelial-Blood_vessel_endothelial-Aerocyte|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

RAPGEF5 PRX RAPGEF4

5.19e-041853837b3d30a54bec66ca6b0209c86448f4fff97ed75c
ToppCellControl-Endothelial-VE_Capillary_A|World / Disease state, Lineage and Cell class

RAPGEF5 PRX RAPGEF4

5.19e-04185383a28187c2fd23564314b35759479ff2ca21f61485
ToppCellmild_COVID-19-Plasmablast|mild_COVID-19 / disease group, cell group and cell class (v2)

TICRR RAPGEF5 CCNB1

5.27e-04186383a639d2183b85b1be6e6da2b2e112aec5149d5bcd
ToppCellfacs-Brain_Non-Myeloid-Striatum_-18m-Neuronal-interneuron|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SEPTIN3 UBN2 RAPGEF4

5.27e-04186383a1ab273b01971d6a892912560d387685dd657179
ToppCell343B-Endothelial_cells-Endothelial-E|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)

RAPGEF5 PRX RAPGEF4

5.27e-04186383080e56113b89138277a2bd2eabddfa6cd1a18b61
ToppCell356C-Endothelial_cells-Endothelial-C_(Capillary_Aerocyte_)-|356C / Donor, Lineage, Cell class and subclass (all cells)

RAPGEF5 PRX RAPGEF4

5.27e-04186383f0b78c7ee20279970ea8961bf59acb5262f2dce5
ToppCell343B-Endothelial_cells-Endothelial-E-|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)

RAPGEF5 PRX RAPGEF4

5.27e-04186383dae6a98963c78bf7518ebab8dc02f173c3b0f7f7
ToppCell356C-Endothelial_cells-Endothelial-C_(Capillary_Aerocyte_)|356C / Donor, Lineage, Cell class and subclass (all cells)

RAPGEF5 PRX RAPGEF4

5.27e-041863832b3c814a7dee8286ea113c63dc3de5daf0257d37
ToppCellFetal_29-31_weeks-Endothelial-alveolar_capillary_endothelial_cell_(Cap2;_aerocyte)-D062|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

RAPGEF5 PRX RAPGEF4

5.36e-0418738397b2463fb37e7196dd2f92553acf8e7bc3ec40dd
ToppCellfacs-Brain_Non-Myeloid-Striatum_-18m-Neuronal-nan|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SEPTIN3 UBN2 RAPGEF4

5.36e-04187383ef3c85c01bc3da408ae288b6e3096ad888a12e63
ToppCellControl-Endothelial-VE_Capillary_A|Control / Disease state, Lineage and Cell class

RAPGEF5 PRX RAPGEF4

5.36e-0418738354d7588172ac145ff5045ad9771636729ca3f0ca
ToppCellLPS-IL1RA+antiTNF-Endothelial-Endothelial-Activated_Alv_Cap|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

RAPGEF5 PRX RAPGEF4

5.36e-04187383f3397dbc23b6c2f24e2c1ba887d8f9aef3ee01a1
ToppCellCOVID-19-Endothelial_cells-Pulmonary_venous_endothelial_cells|COVID-19 / group, cell type (main and fine annotations)

RAPGEF5 ITGB4 RAPGEF4

5.36e-041873832d20193a6cacdfa4877457c97b0077408942186c
ToppCell343B-Endothelial_cells-Endothelial-C_(Capillary_Aerocyte_)-|343B / Donor, Lineage, Cell class and subclass (all cells)

RAPGEF5 PRX RAPGEF4

5.44e-04188383fe7143c36e4a883745862d3c3147cf751b440e46
ToppCelldroplet-Limb_Muscle-Pre-Sort-18m-Macroglial-Schwann_cell|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FGA SEPTIN3 PRX

5.44e-041883833b8b9161f0fdcbde302ce5b4c0bc874628211109
ToppCellLPS-IL1RA+antiTNF-Endothelial-Endothelial-Alv_Cap|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

RAPGEF5 PRX RAPGEF4

5.44e-0418838373f6ec915934154f435a376cb274b058ff7c5f35
ToppCellfacs-Pancreas-Endocrine-24m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MIA3 UBN2 RAPGEF4

5.44e-04188383a91443aa8fa8fa87f7501c59219daa0305bd0bbf
ToppCelldroplet-Limb_Muscle-Pre-Sort-18m-Macroglial|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FGA SEPTIN3 PRX

5.44e-04188383c2101ded71fb16b8ddbc1f883911b1ed2a533ffc
ToppCell343B-Endothelial_cells-Endothelial-C_(Capillary_Aerocyte_)|343B / Donor, Lineage, Cell class and subclass (all cells)

RAPGEF5 PRX RAPGEF4

5.44e-04188383cbf32b675a7cd0c808d5c9c22dfa7fa79fbe2437
ToppCellCOVID-19-lung-Vein_EC|lung / Disease (COVID-19 only), tissue and cell type

RAPGEF5 ITGB4 RAPGEF4

5.44e-04188383d582b76fc2faac526c9bf97503041129e1a6a211
ToppCellLAM-Endothelial-VasEndo-1|LAM / Condition, Lineage and Cell class

RAPGEF5 PRX RAPGEF4

5.52e-04189383454e64b1ee93edebbc1576fbf7c3a6db332fa927
ToppCellCOVID-19-Heart-EC_(POSTN)|COVID-19 / Disease (COVID-19 only), tissue and cell type

RAPGEF5 ITGB4 RAPGEF4

5.52e-041893837346c1112e2e155dbd71b6dbc80e680fd262a691
ToppCellfacs-Brain_Non-Myeloid-Striatum_-18m-Neuronal|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SEPTIN3 UBN2 RAPGEF4

5.52e-041893833d838da870623a6a278ddc8e6cedca85d9877e50
ToppCellLPS_only-Endothelial-Endothelial-Alv_Cap|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

RAPGEF5 PRX RAPGEF4

5.61e-04190383474cbbab8f3b0a6881fa6c92edb78e43999f9ab0
ToppCellLPS-IL1RA+antiTNF-Endothelial-Endothelial-Alv_Gen_Intermediate|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

RAPGEF5 PRX RAPGEF4

5.61e-04190383a3c6eec6df052105ab78b7e3c78f94218d5912eb
ToppCellCOVID-19-Endothelial_cells-Endothelial_cells_(general)|COVID-19 / group, cell type (main and fine annotations)

RAPGEF5 PRX RAPGEF4

5.61e-04190383812e11314c76c0179fbe5a9bea29b41ce5cbc93d
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Cycling_Endothelial_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

TICRR RAPGEF5 RAPGEF4

5.61e-0419038331de1727822e9818652946dfb962daee77ffad68
ToppCellCOVID-19-lung-Vein_EC|COVID-19 / Disease (COVID-19 only), tissue and cell type

RAPGEF5 ITGB4 RAPGEF4

5.61e-041903831caeaef78326734c1e31a0c4739190d5c5a77b9e
ToppCellControl-Endothelial-VE_Capillary_B|Control / Disease state, Lineage and Cell class

RAPGEF5 PRX RAPGEF4

5.69e-04191383322237793a1278bafb14e63cab688b353e352dcc
ToppCellFetal_29-31_weeks-Endothelial-alveolar_capillary_endothelial_cell_(Cap2;_aerocyte)|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

RAPGEF5 PRX RAPGEF4

5.69e-041913831de0bdfd13bd930691564c2673f2e66393bc0255
ToppCellControl-Endothelial-VE_Capillary_B|World / Disease state, Lineage and Cell class

RAPGEF5 PRX RAPGEF4

5.69e-04191383c672c8e28d06d555335976b3f8bd2ea6d3b34aae
ToppCell5'-Airway_Nasal-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal-Suprabasal_L.0.0.1.1|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

TICRR ITGB4 CCNB1

5.69e-041913830f9443da0f73d07456142fae08b2dc92a5b7b592
ToppCellLPS_only-Endothelial-Endothelial-Activated_Alv_Cap|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

RAPGEF5 PRX RAPGEF4

5.69e-04191383a7b18bcf27c38ad2353c239ecb309c80f3ef3359
ToppCellLPS-IL1RA+antiTNF-Endothelial-Endothelial|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

RAPGEF5 PRX RAPGEF4

5.78e-04192383c07d7b40b2aa4eb27ac85801c014a656e2fd01dc
ToppCellCOVID-19-Heart-EC_(POSTN)|Heart / Disease (COVID-19 only), tissue and cell type

RAPGEF5 ITGB4 RAPGEF4

5.78e-04192383c0c34785a7bdf461722029b322e9184e3d9b3c26
ToppCellLPS-antiTNF-Endothelial-Endothelial-Activated_Alv_Cap|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

RAPGEF5 PRX RAPGEF4

5.78e-04192383c618ede75dce3988c87a5b8f98d8e94e1dd66efd
ToppCellLPS_only-Endothelial-Endothelial-Vein|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

RAPGEF5 ITGB4 RAPGEF4

5.78e-0419238352acaecd3703166f5ce3b328aff7c82bd142fee4
ToppCellLPS-IL1RA+antiTNF-Endothelial|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

RAPGEF5 PRX RAPGEF4

5.78e-0419238304f5a2e3dd6beff027b89d66eefdd92036e041af
ToppCellEndothelial-alveolar_capillary_endothelial_cell_(Cap2;_aerocyte)|World / Lineage, Cell type, age group and donor

RAPGEF5 PRX RAPGEF4

5.78e-041923831e156bab5ecf64627890d2de9b27603d9a01f28d
ToppCellnucseq-Endothelial-Endothelial_Vascular-Endothelial_capillary|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

RAPGEF5 PRX RAPGEF4

5.87e-04193383f582e939e3e08a8a3f71deec78c33715be8faa51
ToppCellLPS-IL1RA-Endothelial-Endothelial-Activated_Alv_Cap|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

RAPGEF5 PRX RAPGEF4

5.87e-04193383a3636c35ed25aabe2f1aba016c9fe125327bbfaf
ToppCellFetal_29-31_weeks-Endothelial-capillary_endothelial_cell_(Cap1)-D062|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

RAPGEF5 PRX RAPGEF4

5.87e-04193383ff6e6b825d6c88148216c601580be3c28851ab5c
ToppCellLPS-antiTNF-Endothelial-Endothelial|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

RAPGEF5 PRX RAPGEF4

5.87e-0419338302f633b016ab19bfa65bfd0cf32f000549a62148
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Glomerular_Capillary_Endothelial_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

RAPGEF5 PRX RAPGEF4

5.87e-04193383456aa8a8f1f9cbba0bd618a5f623909079c0f56b
ToppCellPCW_13-14-Endothelial-Endothelial_mature-endo_venous_(13)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

RAPGEF5 ITGB4 RAPGEF4

5.87e-0419338384d1c1b7d3a1cb80f175527e3c89a2c3da7657f7
ToppCellControl-Fibroblasts-Vascular_smooth_muscle|Control / group, cell type (main and fine annotations)

GHR PRX RAPGEF4

5.87e-0419338360e44aac8be0430ad35e20eb98b1b700d76a0427
ToppCellIPF-Endothelial-VE_Capillary_B|World / Disease state, Lineage and Cell class

RAPGEF5 PRX RAPGEF4

5.87e-04193383d7750a7575ef257963b7f1c64fa67c52dbff797b
ToppCellLPS-antiTNF-Endothelial|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

RAPGEF5 PRX RAPGEF4

5.87e-041933835122b1ffba42de190061be34ecdc6176f84e56a3
ToppCellPCW_13-14-Endothelial-Endothelial_mature-endo_capillary_(2)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

RAPGEF5 PRX RAPGEF4

5.96e-041943833c31ac44e8cf4eca3ba7b8bfc05ad3e96a970956
ToppCellPCW_10-12-Endothelial-Endothelial_mature-endo_venous_(13)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

RAPGEF5 ITGB4 RAPGEF4

5.96e-04194383efd5efed060edb7f24d59600981bb60ec28ac2ef
ToppCellLPS-IL1RA-Endothelial-Endothelial|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

RAPGEF5 PRX RAPGEF4

5.96e-041943831d39d968730a7e85b6161c1c8a6bd38afe9bcad7
ToppCellLPS_only-Endothelial|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

RAPGEF5 PRX RAPGEF4

5.96e-0419438358f069efdefa0366033764446b9d6ffd4a17807e
ToppCellCOPD-Endothelial-VE_Capillary_B|COPD / Disease state, Lineage and Cell class

RAPGEF5 PRX RAPGEF4

5.96e-0419438318b7f901c12ca4f21f9a1eafd092aefe4d668b6d
ToppCellLPS_only-Endothelial-Endothelial|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

RAPGEF5 PRX RAPGEF4

5.96e-04194383bfd92ec75facb0ba55c31e5f2e089d983b3d0169
ToppCellAdult-Endothelial|Adult / Lineage, Cell type, age group and donor

RAPGEF5 PRX RAPGEF4

5.96e-04194383963b3fbee0575af8379baa397ace65949eaf34f7
ToppCellChildren_(3_yrs)-Endothelial-capillary_endothelial_cell_(Cap1)-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

PRX MFSD6 RAPGEF4

5.96e-0419438340842a7160f337bfc191ee15fbda3e3d38a04c57
DrugEthamsylate [2624-44-4]; Up 200; 15.2uM; HL60; HT_HG-U133A

FGA ITGB4 PRX MFSD6 RAPGEFL1

1.79e-051963852915_UP
DrugProgesterone [57-83-0]; Up 200; 12.8uM; PC3; HT_HG-U133A

ADAMTS7 CRAT RAPGEF5 PRX RAPGEFL1

1.79e-051963856646_UP
DrugFenbendazole [43210-67-9]; Up 200; 13.4uM; PC3; HT_HG-U133A

MAN1A2 DBT IL1A ADAMTS7 PRX

1.93e-051993853805_UP
DrugPHA-00851261E [724719-49-7]; Up 200; 10uM; PC3; HT_HG-U133A

FGA DBT ADAMTS7 RAPGEF5 PHF3

1.97e-052003853773_UP
Diseaseplasma beta-amyloid 1-40 measurement

OMA1 EP400P1

1.95e-0417362EFO_0005659
Diseaseresponse to antineoplastic agent

GHR PPP2R5E MTUS2

2.41e-0499363GO_0097327
DiseaseCongenital small ears

KMT2D LEMD3

1.15e-0341362C0152423
Diseasebreast cancer (is_marker_for)

GHR KMT2D CCNB1

1.49e-03185363DOID:1612 (is_marker_for)
DiseaseMale sterility

KMT2D NSUN7

1.58e-0348362C0917731
DiseaseMale infertility

KMT2D NSUN7

1.58e-0348362C0021364
DiseaseSubfertility, Male

KMT2D NSUN7

1.58e-0348362C0848676

Protein segments in the cluster

PeptideGeneStartEntry
KPIELTPLPLLKDVP

PPP2R5E

41

Q16537
VVPRSKPLMLIAPKP

ADNP

261

Q9H2P0
ELVRSPLVPLPMPKK

CRAT

366

P43155
SLLPPPIAPLPEMKV

ADAMTS7

1291

Q9UKP4
PIIMPKPKHVRPKII

MTUS2

631

Q5JR59
AKKLTPLLPPPLTDM

LEMD3

361

Q9Y2U8
KPKDMTVPILVSKPP

DBT

231

P11182
PVLLKEMPEIPKTIT

IL1A

201

P01583
VPKKLEEIPPASPEM

EP400P1

336

Q6ZTU2
VMPRIEPRLPPKKTK

MFSD6

661

Q6ZSS7
KRPMSIPIIPDIPIV

ITGB4

1321

P16144
KPLEKVPMLVPVPVS

CCNB1

81

P14635
QRIKMLILPPVPVPK

GHR

291

P10912
ILPPQEKKKPELLLP

HEATR4

276

Q86WZ0
LPVPQPEIMEVPKAK

CSN2

91

P05814
LPLIKMKPVPDLVPG

FGA

221

P02671
QEMKIKENKPLPPVP

MAN1A2

146

O60476
LEIPMLIPKEKPPIT

PRPSAP2

241

O60256
LKKLGVMPPEQPLPV

INPP5F

481

Q9Y2H2
KPTCIPPELPKMLKE

ROPN1B

6

Q9BZX4
LEPPLIPFMPLLIKD

RAPGEF4

916

Q8WZA2
QPPIIPLFPVVKKDM

RAPGEF6

1006

Q8TEU7
IIEGPIIKLMILPDP

SMCHD1

1351

A6NHR9
IIKLMILPDPEKPVR

SMCHD1

1356

A6NHR9
LQEEPVIVKPMPGKP

MIA3

1636

Q5JRA6
DRMVALKPIKIVLPP

NSUN7

641

Q8NE18
PAPLEKPIVLMKPRE

SMG9

91

Q9H0W8
PPKIPFMPLLLKDVT

RAPGEF5

491

Q92565
PVPLLLMILKPVQKL

OMA1

146

Q96E52
LIIPPLPEKFIVKGM

SNX7

91

Q9UNH6
VIKHPELTKPPPLMA

TBC1D24

446

Q9ULP9
MPKVVPTLPEGLPVL

UBN2

441

Q6ZU65
LPPTPKQVMEKLLPK

TICRR

181

Q7Z2Z1
ELVPEPRPKPAVPMK

SEPTIN3

16

Q9UH03
KPTCIPPELPKMLKE

ROPN1

6

Q9HAT0
PEMKLPEVQLPKVPE

PRX

596

Q9BXM0
LPEMKLPEVKLPKVP

PRX

631

Q9BXM0
LPEVKLPKVPEMAVP

PRX

636

Q9BXM0
EPLMEVTKQEPPKPL

PHF3

1426

Q92576
SKMKPPVIPFVPLIL

RAPGEFL1

566

Q9UHV5
PVAPPELVPMKVKEP

KMT2D

1566

O14686