Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
HumanPhenoDecreased fertility

OBSL1 FSIP2 FLRT3 SPAG17 FCGR2A SEPTIN12

5.55e-05380116HP:0000144
MousePhenoabnormal sperm fibrous sheath morphology

FSIP2 RSPH6A SPAG17

4.69e-0532313MP:0030590
MousePhenoabnormal sperm principal piece morphology

FSIP2 RSPH6A SPAG17

1.32e-0445313MP:0009836
MousePhenoabsent sperm fibrous sheath

FSIP2 SPAG17

1.32e-048312MP:0030591
DomainIGc2

OBSL1 NEO1 HMCN1 FCGR2A SIGLEC8 VSIG10L

5.29e-06235366SM00408
DomainIg_sub2

OBSL1 NEO1 HMCN1 FCGR2A SIGLEC8 VSIG10L

5.29e-06235366IPR003598
DomainDUF3377

MMP24 MMP15

2.16e-054362PF11857
DomainPept_M10A_metallopeptidase_C

MMP24 MMP15

2.16e-054362IPR021805
DomainIG

OBSL1 NEO1 HMCN1 FCGR2A SIGLEC8 VSIG10L

1.39e-04421366SM00409
DomainIg_sub

OBSL1 NEO1 HMCN1 FCGR2A SIGLEC8 VSIG10L

1.39e-04421366IPR003599
Domain-

OBSL1 NEO1 FLRT3 HMCN1 FCGR2A SIGLEC8 VSIG10L

2.34e-046633672.60.40.10
DomainIG_LIKE

OBSL1 NEO1 HMCN1 FCGR2A SIGLEC8 VSIG10L

3.19e-04491366PS50835
DomainIg-like_fold

OBSL1 NEO1 FLRT3 HMCN1 FCGR2A SIGLEC8 VSIG10L

3.43e-04706367IPR013783
DomainIg-like_dom

OBSL1 NEO1 HMCN1 FCGR2A SIGLEC8 VSIG10L

3.63e-04503366IPR007110
DomainIg_2

NEO1 FCGR2A VSIG10L

3.73e-0473363PF13895
DomainIg_I-set

OBSL1 NEO1 HMCN1 SIGLEC8

4.74e-04190364IPR013098
Domainig

OBSL1 HMCN1 FCGR2A SIGLEC8

4.74e-04190364PF00047
DomainImmunoglobulin

OBSL1 HMCN1 FCGR2A SIGLEC8

4.74e-04190364IPR013151
DomainI-set

OBSL1 NEO1 HMCN1 SIGLEC8

4.74e-04190364PF07679
DomainHemopexin_CS

MMP24 MMP15

4.82e-0417362IPR018486
DomainPept_M10A_stromelysin-type

MMP24 MMP15

5.42e-0418362IPR016293
DomainPG_binding_1

MMP24 MMP15

6.72e-0420362PF01471
DomainPeptidoglycan-bd-like

MMP24 MMP15

6.72e-0420362IPR002477
DomainHemopexin-like_dom

MMP24 MMP15

8.91e-0423362IPR000585
DomainHemopexin-like_repeat

MMP24 MMP15

8.91e-0423362IPR018487
DomainM10A_MMP

MMP24 MMP15

8.91e-0423362IPR033739
DomainHemopexin

MMP24 MMP15

8.91e-0423362PF00045
DomainHEMOPEXIN

MMP24 MMP15

8.91e-0423362PS00024
Domain-

MMP24 MMP15

8.91e-04233622.110.10.10
DomainHEMOPEXIN_2

MMP24 MMP15

8.91e-0423362PS51642
DomainHX

MMP24 MMP15

8.91e-0423362SM00120
DomainPept_M10A

MMP24 MMP15

8.91e-0423362IPR021190
DomainPeptidase_M10

MMP24 MMP15

9.71e-0424362PF00413
DomainZnMc

MMP24 MMP15

1.42e-0329362SM00235
DomainPeptidase_Metallo

MMP24 MMP15

1.42e-0329362IPR006026
DomainRA

ARAP3 RAPH1

2.18e-0336362PF00788
DomainRA

ARAP3 RAPH1

2.31e-0337362PS50200
DomainRA_dom

ARAP3 RAPH1

2.69e-0340362IPR000159
DomainCYSTEINE_SWITCH

MMP24 MMP15

2.83e-0341362PS00546
DomainPept_M10_metallopeptidase

MMP24 MMP15

3.10e-0343362IPR001818
Domainfn3

OBSL1 NEO1 FLRT3

3.71e-03162363PF00041
Pubmed

Changes in the expression of membrane type-matrix metalloproteinases genes (MMP14, MMP15, MMP16, MMP24) during treatment and their potential impact on the survival of patients with non-small cell lung cancer (NSCLC).

MMP24 MMP15

6.96e-06438235062057
Pubmed

mRNA expression of the five membrane-type matrix metalloproteinases MT1-MT5 in human prostatic cell lines and their down-regulation in human malignant prostatic tissue.

MMP24 MMP15

1.16e-05538212661033
Pubmed

MT3-MMP Promotes Excitatory Synapse Formation by Promoting Nogo-66 Receptor Ectodomain Shedding.

MMP24 MMP15

1.16e-05538229196321
Pubmed

Membrane-type matrix metalloproteinases: Their functions and regulations.

MMP24 MMP15

2.43e-05738225794647
Pubmed

E-cadherin interactome complexity and robustness resolved by quantitative proteomics.

KIAA1671 MAGI3 FNBP1L SCEL RAPH1 VSIG10L

3.18e-0556538625468996
Pubmed

A BioID-Derived Proximity Interactome for SARS-CoV-2 Proteins.

KIAA1671 MAGI3 FLRT3 EMC1 C2CD2 TNRC6A

1.20e-0471938635337019
Pubmed

Matrix metalloproteinases in tumor invasion.

MMP24 MMP15

1.38e-041638210949577
Pubmed

Matrix metalloproteinases.

MMP24 MMP15

2.65e-042238210419448
Pubmed

Functional interactions between matrix metalloproteinases and glycosaminoglycans.

MMP24 MMP15

2.65e-042238223421805
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

KDM2B FLRT3 EMC1 BAHD1 TNRC6A

2.65e-0452938514621295
Pubmed

Matrix metalloproteinases 2 and 9 are dispensable for pancreatic islet formation and function in vivo.

MMP24 MMP15

3.16e-042438215734845
Pubmed

Nkx6.1 controls migration and axon pathfinding of cranial branchio-motoneurons.

NEO1 IRX3

3.16e-042438214534138
Pubmed

A central chaperone-like role for 14-3-3 proteins in human cells.

KIAA1671 FSIP2 MAGI3 EMC1 TRAPPC14 RAPH1

3.18e-0486138636931259
Pubmed

Proximity labeling reveals dynamic changes in the SQSTM1 protein network.

KIAA1671 OBSL1 MRPL45 TNRC6A

4.15e-0432238439098523
Pubmed

Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.

KIAA1671 OBSL1 KDM2B FNBP1L TNRC6A

4.30e-0458838538580884
Pubmed

Proteomic analysis of complexes formed by human topoisomerase I.

PRPF8 TOP1

5.65e-043238215848144
Pubmed

Endogenous Cell Type-Specific Disrupted in Schizophrenia 1 Interactomes Reveal Protein Networks Associated With Neurodevelopmental Disorders.

EMC1 TOP1 GLYR1

6.65e-0415638329961565
Pubmed

Quantifying domain-ligand affinities and specificities by high-throughput holdup assay.

MAGI3 PTPN4

7.15e-043638226053890
Pubmed

Interferon gamma receptor 2 gene variants are associated with liver fibrosis in patients with chronic hepatitis C infection.

MMP24 MMP15

7.15e-043638220587546
Pubmed

Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.

KIAA1671 PTPN4 EMC1 RAPH1 GLYR1 TNRC6A

8.97e-04104938627880917
Pubmed

Identification of Novel Proteins Co-Purifying with Cockayne Syndrome Group B (CSB) Reveals Potential Roles for CSB in RNA Metabolism and Chromatin Dynamics.

PRPF8 TOP1

1.02e-034338226030138
Pubmed

Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.

KIAA1671 DIP2C MAGI3 PTPN4 FNBP1L C2CD2 GLYR1

1.02e-03148938728611215
Pubmed

The histone acetyltransferase KAT6A is recruited to unmethylated CpG islands via a DNA binding winged helix domain.

MRPL45 PRPF8 TOP1 GLYR1

1.09e-0341738436537216
GeneFamilyImmunoglobulin like domain containing

OBSL1 NEO1 FCGR2A VSIG10L

2.11e-04193284594
GeneFamilyEndogenous ligands|Matrix metallopeptidases

MMP24 MMP15

6.25e-0424282891
GeneFamilyBlood group antigens|CD molecules|I-set domain containing|Immunoglobulin like domain containing

OBSL1 NEO1 HMCN1

1.93e-03161283593
CoexpressionAtlasdev gonad_e12.5_F_DevVasOvary_Flk_k-means-cluster#4_top-relative-expression-ranked_1000

IRX3 HMCN1 MMP15

5.34e-0542373gudmap_dev gonad_e12.5_F_gudmap_devVasOvary_Flk_k4_1000
CoexpressionAtlasdev gonad_e13.5_F_DevVascOvary_Flk_top-relative-expression-ranked_1000

MAGI3 PTPN4 IRX3 ARAP3 HMCN1 RAPH1 MMP15 ZNF366

7.48e-05831378gudmap_dev gonad_e13.5_F_gudmap_devVascOvary_Flk_1000
ToppCellPND14-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT1-AT1_mature|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

MAGI3 IRX3 FLRT3 SCEL ANKRD34B

4.62e-07182385573771130247e869e4e58f22d4a1cb31989635cf
ToppCellPND14-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT1|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

MAGI3 IRX3 FLRT3 SCEL ANKRD34B

4.62e-071823856cfaa2b3b3974c13b01c943f4adb70768dcc35e4
ToppCellRV-09._Endothelium_I|World / Chamber and Cluster_Paper

KIAA1671 FNBP1L ARAP3 HMCN1 ZNF366

6.17e-07193385e3fa47e2c7cd8a5b69186711c57751f2296de8ae
ToppCellASK440-Epithelial|ASK440 / Donor, Lineage and Cell class of Lung cells from Dropseq

MAGI3 IRX3 FLRT3 SCEL SPAG17

7.36e-07200385cb617e2a0ca82b470b473b8d5906bc8879c85718
ToppCellBAL-Mild-Myeloid-cDC-cDC-cDC_4|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

FNBP1L ZNF366 SIGLEC8 PLD4

7.81e-06149384a85a051e0d82430160967e72fa04b55f43e84513
ToppCellBAL-Mild-Myeloid-cDC-cDC-cDC_4|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

FNBP1L ZNF366 SIGLEC8 PLD4

8.02e-061503847a381f5ae94eba5eb60dcbf83416b4eb18c279ea
ToppCellfacs-Lung-3m-Epithelial-alveolar_epithelial-type_I_pneumocyte-type_1_alveolar_epithelial_cell|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

MAGI3 IRX3 FLRT3 SCEL

1.22e-051673849f2661729a2d58e17a9203a563d538c08a3dbbbc
ToppCellfacs-Lung-3m-Epithelial-alveolar_epithelial-type_I_pneumocyte|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

MAGI3 IRX3 FLRT3 SCEL

1.22e-05167384bebc2493a2ee41920b21c2b774a1c5a9619315c4
ToppCellmild_COVID-19-pDC|World / disease group, cell group and cell class (v2)

OBSL1 HMCN1 MMP15 PLD4

1.38e-05172384dab2f1a05c7df58d9387b13271b3f1f1583f9ac3
ToppCellPBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Myeloid-Granulocytic-Neutrophil|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)

RSPH6A ANKRD34B SPAG17 FCGR2A

1.38e-05172384c32e6af9e2d29da47b5d870207b598cff11aef6c
ToppCellPBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Myeloid-Granulocytic-Neutrophil-Neu_c1-IL1B|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)

RSPH6A ANKRD34B SPAG17 FCGR2A

1.38e-051723840b247fe57163af08132db8df42e6757699885295
ToppCellPBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Myeloid-Granulocytic|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)

RSPH6A ANKRD34B SPAG17 FCGR2A

1.38e-051723841a0556c97fcba126126c22adea5235d977d41ebe
ToppCell367C-Epithelial_cells-Epithelial-I_(AT1)-|367C / Donor, Lineage, Cell class and subclass (all cells)

MAGI3 MMP24 FLRT3 SCEL

1.44e-05174384edf839d79ac58921f4e788f3b2cb2ae0d6af4b9e
ToppCell367C-Epithelial_cells-Epithelial-I_(AT1)|367C / Donor, Lineage, Cell class and subclass (all cells)

MAGI3 MMP24 FLRT3 SCEL

1.44e-0517438465539f69100db0b7d90b1b39ee15ab8281f86461
ToppCellkidney_cells-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_2|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

IRX3 FLRT3 ANKRD34B SPAG17

1.51e-0517638433323c97afe509147956b8df9f92ca6b0537e604
ToppCellfacs-Lung-EPCAM-3m-Epithelial-Alveolar_Epithelial_Type_1|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MAGI3 IRX3 FLRT3 SCEL

1.61e-0517938488dbec952507d84b85b08165eec80df99ed1e736
ToppCellfacs-Lung-EPCAM-3m-Epithelial-type_I_pneumocyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MAGI3 IRX3 FLRT3 SCEL

1.61e-05179384daf8189a22786171e2b629261cf720736aa4ebdb
ToppCellCOVID-19-Epithelial_cells-AT1|COVID-19 / group, cell type (main and fine annotations)

MAGI3 FLRT3 FNBP1L SCEL

1.61e-05179384a0b33bd69ffdfd5d38d80207fb40058a490aa19e
ToppCellAT1-AT2_cells-Donor_02|World / lung cells shred on cell class, cell subclass, sample id

MAGI3 MMP24 FNBP1L SCEL

1.75e-051833846821dca076318115d360ff426eb1218cfe104063
ToppCellLV-10._Endothelium_II|World / Chamber and Cluster_Paper

KIAA1671 ARAP3 HMCN1 ZNF366

1.91e-051873847876dcb4800c2e54874df3d933efb79307a64a97
ToppCellLPS_only-Epithelial_alveolar-AT_1|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

MAGI3 IRX3 FLRT3 SCEL

1.91e-05187384ff26a533d310126521efe1d05cf8b9d32e524550
ToppCellAdult-Epithelial-alveolar_epithelial_cell_type_1-D231|Adult / Lineage, Cell type, age group and donor

DIP2C MAGI3 FNBP1L SCEL

1.99e-051893845a04cb25f8f0447b2cecdb6c3695029281aca26d
ToppCellPND07-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT1|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

MAGI3 FLRT3 SCEL ANKRD34B

2.08e-05191384ce76b156b153a2c7c9f2fb8e563b69c81073fbe5
ToppCellPND07-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT1-AT1_mature|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

MAGI3 FLRT3 SCEL ANKRD34B

2.08e-05191384c006f5a6e3a32b79ac99a78304bdd5116fc0d5e0
ToppCell(1)_Control_(PBS)-(1)_VE-Cad+_vascular_cells|(1)_Control_(PBS) / Stress and Cell class

KIAA1671 FNBP1L ARAP3 HMCN1

2.12e-05192384e16e49b302019474232ef4cc0ff217d33afe34cf
ToppCellPND03-Epithelial|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

MAGI3 IRX3 FLRT3 SPAG17

2.12e-05192384d8c23693f690d4d568585537bbfedda05d505b3d
ToppCellRV-10._Endothelium_II|RV / Chamber and Cluster_Paper

KIAA1671 ARAP3 HMCN1 RAPH1

2.16e-0519338401c2df9206f1527c578e808978e58196c35e72f5
ToppCellLPS-antiTNF-Endothelial-Endothelial-Gen_Cap|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

KIAA1671 ARAP3 HMCN1 ZNF366

2.16e-051933846e1982d089a9de628e6006d23ff78a223fbd9f47
ToppCellRV-10._Endothelium_II|World / Chamber and Cluster_Paper

KIAA1671 ARAP3 HMCN1 RAPH1

2.16e-051933842531266bc57339d4e2b22a88817008e32b8c1598
ToppCellRV-09._Endothelium_I|RV / Chamber and Cluster_Paper

KIAA1671 ARAP3 HMCN1 ZNF366

2.21e-051943847b408096e717f2327c12aea35a8d5fc4621d3b06
ToppCellLV-10._Endothelium_II|LV / Chamber and Cluster_Paper

KIAA1671 ARAP3 HMCN1 ZNF366

2.21e-05194384b6cc849fa08599bff9839ef382d190cc964e273e
ToppCellLV-09._Endothelium_I|World / Chamber and Cluster_Paper

KIAA1671 ARAP3 HMCN1 ZNF366

2.25e-0519538419e0a6c3eae1615aaa39767300acd937dfcb2a7f
ToppCellLA-09._Endothelium_I|World / Chamber and Cluster_Paper

KIAA1671 ARAP3 HMCN1 ZNF366

2.25e-05195384fc95457a298b5d0dab687d9ee7e225a7f7b9a0d4
ToppCellPND03-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT1-AT1_mature|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

MAGI3 FLRT3 FNBP1L SCEL

2.30e-051963849790340c25f446ec655f5a0b64ec3bb44ed2e1bd
ToppCellPND03-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT1|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

MAGI3 FLRT3 FNBP1L SCEL

2.30e-05196384b9ceceeacbcf81976ce92adf044f0d0aa132632b
ToppCell(7)_Epithelial-I_(AT1)|World / Lung cell shreds - cell class (v4) and cell subclass (v4)

MAGI3 MMP24 FLRT3 SCEL

2.30e-05196384150554fa06868d29b0608189862eef6505ba757f
ToppCellEpithelial-A_(AT1)|World / shred on cell class and cell subclass (v4)

MAGI3 IRX3 FLRT3 SCEL

2.30e-05196384484bbc6b1f58bc260964babb949d14f5df101393
ToppCellLA-09._Endothelium_I|LA / Chamber and Cluster_Paper

KIAA1671 ARAP3 HMCN1 ZNF366

2.34e-05197384ab6d1ab586a188597a39854ef980b8955ebcc645
ToppCellLV-09._Endothelium_I|LV / Chamber and Cluster_Paper

KIAA1671 ARAP3 HMCN1 ZNF366

2.34e-05197384f9731d4d636e51b94a96805eee6afe9aedc175e3
ToppCell390C-Myeloid-Dendritic|390C / Donor, Lineage, Cell class and subclass (all cells)

KDM2B FCGR2A ZNF366 PLD4

2.34e-05197384424526c94b9a73c1c28ddc65dfba53aba5c6b2d2
ToppCellAT2_cells-SSc-ILD_01|World / lung cells shred on cell class, cell subclass, sample id

FLRT3 SCEL DCBLD2 TOP1

2.34e-0519738442e49a8ce3118db6c2fd620d70c480b75143c828
ToppCellBiopsy_IPF-Epithelial-AT1|Biopsy_IPF / Sample group, Lineage and Cell type

MAGI3 MMP24 FLRT3 SCEL

2.39e-0519838475bdecbe111fededf6082b11de18b84ca308ef6d
ToppCellLPS_IL1RA-Epithelial_alveolar-AT_1-2_Progenitor-Progenitor_AT1-AT2|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

MAGI3 IRX3 FLRT3 SCEL

2.39e-051983848d9858dcb21f20d0c040b22a2cae543eaebd54bc
ToppCellLPS_anti-TNF-Epithelial_alveolar-AT_1-2_Progenitor-Progenitor_AT1-AT2|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

MAGI3 IRX3 FLRT3 SCEL

2.39e-0519838450852713c017217c79777c95857097103bcf2fbe
ToppCelldistal-2-Epithelial-Club|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

IRX3 FLRT3 SCEL ANKRD34B

2.39e-051983843055c03896fbfac82a3072e51c0c54d68131cf1a
ToppCellBAL-Severe-Epithelial-Epithelial-AT1/AT2|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

FLRT3 SCEL MMP15 DCBLD2

2.39e-05198384aed0476248e9637897eefb1623ec4035f2dacd82
ToppCellBAL-Severe-Epithelial-Epithelial-AT1/AT2-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

FLRT3 SCEL MMP15 DCBLD2

2.39e-05198384691a2f1779225e5519155460eeb6a2aac5f67a92
ToppCellBAL-Severe-Epithelial-Epithelial-AT1/AT2|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)

FLRT3 SCEL MMP15 DCBLD2

2.39e-05198384e115eea04012e9e492e923ed080e1723c38d14fd
ToppCellBronchial-10x5prime-Epithelial-Epi_alveolar-AT1|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

MAGI3 MMP24 FLRT3 SCEL

2.39e-0519838454228dd9a50616d2022712d162a419ed0327cabd
ToppCellBAL-Severe-Epithelial-Epithelial-AT1/AT2-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

FLRT3 SCEL MMP15 DCBLD2

2.39e-0519838433d1e0b6f57663544bee0ffdde83a65da764d44c
ToppCellSevere_COVID-19-Epithelial-AT1/AT2|Severe_COVID-19 / Disease group,lineage and cell class （2021.01.30）

FLRT3 SCEL MMP15 DCBLD2

2.39e-0519838443e33d28d9de5033bd00d39be953542a225236ed
ToppCellParenchymal-10x5prime-Epithelial-Epi_alveolar-AT1|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

MAGI3 MMP24 FLRT3 SCEL

2.44e-05199384aca81a879ef9c196bd1885eff4c63ffe6c9682b7
ToppCellLung_Parenchyma-Control-Epithelial-Epithelial-Transitional_AT2|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)

MAGI3 IRX3 FLRT3 SCEL

2.44e-05199384b44d74895846e2ac144438b73e0ca91e3949c16c
ToppCellControl_saline|World / Treatment groups by lineage, cell group, cell type

FNBP1L ARAP3 SCEL HMCN1

2.44e-0519938411c9c1779caceb725ecccf3f23b7d4e6dbd1af64
ToppCellLung_Parenchyma-Control-Epithelial-Epithelial-Transitional_AT2-|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

MAGI3 IRX3 FLRT3 SCEL

2.44e-051993844b374a5de82b4614d3d8a00202ea6cb8f1fd8104
ToppCellLPS_only-Epithelial_alveolar-AT_1-AT1|LPS_only / Treatment groups by lineage, cell group, cell type

MAGI3 IRX3 FLRT3 SCEL

2.44e-05199384ccdde5d4bcc72f230a1dd2544ee7f4dfb98a5e80
ToppCellTransplant_Alveoli_and_parenchyma-Mesenchymal-Mesothelium|Mesenchymal / Tissue, Lineage and Cell class of Lung Cells from 10X

OBSL1 FLRT3 DCBLD2 HPR

2.44e-051993846cfefd81e8a1a883fb4279ac4ab0b298ed2a0817
ToppCellLPS_IL1RA_TNF-Epithelial_alveolar-AT_1|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

MAGI3 IRX3 FLRT3 SCEL

2.44e-051993841c70e7d6bd25980e1b92aa1cac3f3c95d9651b4b
ToppCellLPS_IL1RA_TNF-Epithelial_alveolar-AT_1-AT1|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

MAGI3 IRX3 FLRT3 SCEL

2.44e-051993848c9ec5f05b79cf5ae1bf7aade603c171fb0226a9
ToppCellASK452-Epithelial|ASK452 / Donor, Lineage and Cell class of Lung cells from Dropseq

IRX3 FLRT3 SCEL SPAG17

2.44e-05199384e8778d4d2bc7e15b4c7989a93e5808a76738df46
ToppCellParenchyma_Control_(B.)-Epithelial-TX-Transitional_AT2|Parenchyma_Control_(B.) / Sample group, Lineage and Cell type

MAGI3 IRX3 FLRT3 SCEL

2.44e-051993849e8231c9007d8d963805a4c99e0905538ceb9b60
ToppCellLPS_IL1RA_TNF-Epithelial_alveolar|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

MAGI3 IRX3 FLRT3 SCEL

2.48e-05200384c89f3cb36bb14c476d6a392bfd3ded1c8feecfeb
ToppCellLPS_IL1RA_TNF-Epithelial_alveolar-AT_1-Differentiating_AT1|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

MAGI3 IRX3 FLRT3 SCEL

2.48e-05200384ddfb1f006365bf16203ee49f20200f68220cc288
ToppCellLPS_only-Epithelial_alveolar-AT_1|LPS_only / Treatment groups by lineage, cell group, cell type

MAGI3 IRX3 FLRT3 SCEL

2.48e-052003849a6ae40f3e17cd44ee5fd73260713b920aa2ea15
ToppCellBiopsy_Other_PF-Epithelial-Transitional_AT2|Biopsy_Other_PF / Sample group, Lineage and Cell type

MAGI3 MMP24 FLRT3 SCEL

2.48e-052003841ba6327851aa61e9a1f1fe1671bc27929d93ac74
ToppCellTCGA-Lung-Primary_Tumor-Lung_Carcinoma-Lung_Acinar_Adenocarcinoma-7|TCGA-Lung / Sample_Type by Project: Shred V9

MAGI3 SHF HMCN1

1.85e-041303830219d0d5d21df08f816569c7eb34f1bfa095d29a
ToppCellBALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_B-B_cell-B_c04-SOX5-TNFRSF1B|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

FNBP1L PLD4 VSIG10L

2.39e-0414238366135fee18448cc09a78bc6ede05afd63c72ae21
ToppCellCerebellum-Endothelial-ENDOTHELIAL_STALK-Flt1_1|Cerebellum / BrainAtlas - Mouse McCarroll V32

ARAP3 HMCN1 ZNF366

2.55e-0414538337580218f6a6f65a1d827cbcf59465f8827f9a55
ToppCellfacs-Diaphragm-Limb_Muscle-18m-Myeloid-nan|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FLRT3 BAHD1 PLD4

2.60e-0414638369cbe8d4772f8e46a5e1a1cdca0e370308a97b4f
ToppCellBAL-Mild-Myeloid-cDC-cDC-cDC_3|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

ZNF366 SIGLEC8 PLD4

2.87e-041513830b6b37734430918378ed94e40877f0c4ae9b25ec
ToppCellPBMC-Control-Myeloid-cDC-cDC-cDC_8|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

ZNF366 C2CD2 PLD4

2.87e-04151383cba0939a6dd3519f6890695f5b237266ca1a7941
ToppCellBAL-Mild-Myeloid-cDC-cDC-cDC_3|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

ZNF366 SIGLEC8 PLD4

2.87e-0415138330225a1a7800b0ae19e16ac164f561379eedb99d
ToppCellPBMC-Control-Myeloid-cDC-cDC-cDC_8|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

ZNF366 C2CD2 PLD4

2.87e-04151383a937e3e5a63bfeb37d2cabb3177760ec583dbf11
ToppCellHealthy_donor-B_cell|Healthy_donor / disease group, cell group and cell class (v2)

OBSL1 FNBP1L SHF

2.92e-041523835768edfde8010324d8594815e73bbfba2c3045f3
ToppCellFrontal_cortex-Endothelial-ENDOTHELIAL_STALK|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

IRX3 ARAP3 ZNF366

3.04e-04154383b0735365de153d4586ca17896431d7bd9c7d8eac
ToppCell390C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_5|390C / Donor, Lineage, Cell class and subclass (all cells)

PTPN4 HMCN1 ZNF366

3.10e-04155383afdd0aba0f3788c2fb916ffb453c5dd7cde2304c
ToppCellPBMC_fresh-frozen-Severe-critical_convalescent_d42-56-Myeloid-Dendritic-conventional_dendritic_cell-DC_c1-CLEC9A|Severe-critical_convalescent_d42-56 / Compartment, severity and other cell annotations on 10x 3' data (130k)

FNBP1L ZNF366 PLD4

3.21e-0415738319c0599a669803c4db1f174de1ce755e562a50a3
ToppCell10x_3'_v3-tissue-resident_(10x_3'_v3)-myeloid-myeloid_macrophage-microglial_cell|tissue-resident_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

FCGR2A SIGLEC8 PLD4

3.34e-0415938331ec8222c766cb614e1cf27f74ee9d99489eca5c
ToppCell356C-Lymphocytic-NK_cells-NK_cell_A2|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

OBSL1 IRX3 FNBP1L

3.46e-041613838ec923c230a7a3cce5edf2a736b3a00d607c698a
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d03-09-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c04-ANXA2|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)

DIP2C MAGI3 SEPTIN12

3.46e-04161383580153e131247e6ec12a1a920f050a0a763e7e87
ToppCell356C-Epithelial_cells-Epithelial-C_(AT2)-|356C / Donor, Lineage, Cell class and subclass (all cells)

IRX3 DCBLD2 HPR

3.46e-0416138378cb72c462167021195917a06052bcdc367ad890
ToppCell356C-Epithelial_cells-Epithelial-C_(AT2)|356C / Donor, Lineage, Cell class and subclass (all cells)

IRX3 DCBLD2 HPR

3.46e-0416138306e7becfd11d6ef1a45a9cfdfcb40b812600038e
ToppCell10x5'v1-week_17-19-Hematopoietic-HSC/MPP_and_pro-HSC/MPP|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

OBSL1 SPAG17 VSIG10L

3.46e-04161383aee74a2e7a8acd2950341963f1c04b59c7862183
ToppCellTCGA-Brain-Primary_Tumor-Low_Grade_Glioma-Astrocytoma|TCGA-Brain / Sample_Type by Project: Shred V9

FNBP1L SIGLEC8 PLD4

3.52e-04162383810881210e015c788814e4fe8d7a24c929cf2621
ToppCellTCGA-Stomach-Primary_Tumor-Stomach_Adenocarcinoma-Stomach_Adenocarcinoma_-_NOS-4|TCGA-Stomach / Sample_Type by Project: Shred V9

SCEL SPAG17 VSIG10L

3.59e-041633836a12b802cb181f979ebc72674f3626fb855024e3
ToppCellBronchial-NucSeq-Endothelial-Endothelia_vascular-VE_systemic_arterial|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

ARAP3 HMCN1 ZNF366

3.65e-041643833cd80e6275f0f9b5667912139d15ebf5e6b17f2f
ToppCell5'-Adult-Appendix-Epithelial-goblet-BEST2+_Goblet_cell|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SCEL DCBLD2 SEPTIN12

3.65e-0416438329da0175bd3808a5b3039a6161c764105608ef96
ToppCell5'-Adult-Appendix-Epithelial-goblet|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SCEL DCBLD2 SEPTIN12

3.65e-04164383e83b632ac7e1dace946991ddfe1fbfbbffc3a88b
ToppCellsaliva-Severe-critical_progression_d12-22_with-steroid-Myeloid-Macrophage|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

FSIP2 TRAPPC14 BAHD1

3.72e-04165383436ce4bc75e1ba4351c439ccad19f84ad5bcb92f
ToppCellCerebellum-Endothelial-ENDOTHELIAL_STALK|Cerebellum / BrainAtlas - Mouse McCarroll V32

ARAP3 HMCN1 ZNF366

3.72e-041653837d319a112b9062efee428bef6f4534d2ce782e04
ToppCellsaliva-Severe-critical_progression_d12-22_with-steroid-Myeloid-Macrophage-macrophage,_alveolar|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

FSIP2 TRAPPC14 BAHD1

3.72e-04165383242bdb7654f415391fb8e9bdc06412c7eee9c97e
ToppCell356C-Myeloid-Monocyte-CD16+_Monocyte|356C / Donor, Lineage, Cell class and subclass (all cells)

KIAA1671 SHF RAPH1

3.72e-0416538335a6de30438de364ccca948fc932da541a69ef89
ToppCellfacs-Lung-nan-3m-Epithelial-type_I_pneumocyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MAGI3 FLRT3 SCEL

3.78e-0416638311b0ae82b3068ef91715dbdd49fe8e9791b4a480
ToppCellfacs-Lung-nan-3m-Epithelial-Alveolar_Epithelial_Type_1|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MAGI3 FLRT3 SCEL

3.78e-04166383fcc1aec31ebd39432d4cb284dc8fadf34e3c566a
ToppCelldroplet-Marrow-nan-24m-Lymphocytic-plasma_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FNBP1L SCEL PLD4

3.78e-04166383b3d9b61847c6c96b8cb28b8a6aeda52f43c706ab
ToppCell368C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_1.5|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

KIAA1671 SHF PLD4

3.92e-0416838394cded2e953c0970bf2f3dbe0ce46bd77a5ed8c7
ToppCell368C-Fibroblasts-Fibroblast-J_(Lipofibroblast)|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

FLRT3 MMP15 HPR

3.92e-04168383e870d2e69316406f45112ed0bf324b24f902a99e
ToppCell368C-Fibroblasts-Fibroblast-J_(Lipofibroblast)-|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

FLRT3 MMP15 HPR

3.92e-04168383403aba73a0f9ffb32252288d075fad8a588ca440
ToppCell10x5'v1-week_17-19-Myeloid_neutrophil-granulo-neutrophil-promyelocyte|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

OBSL1 NEO1 HPR

3.99e-04169383f33f4a0baad1b3cb5be61dfc7b00c7a3845f7120
ToppCell3'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_I_pneumocyte-AT1-AT1_L.0.5.1.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

MAGI3 FLRT3 SCEL

3.99e-04169383cd16e8462ee09877be962fbd9a3badcb825820b0
ComputationalNeighborhood of NUMA1

TRAPPC14 PRPF8 BAHD1

1.22e-0456193GCM_NUMA1
Diseasesystemic lupus erythematosus (implicated_via_orthology)

FCGR2A PLD4

1.41e-0343382DOID:9074 (implicated_via_orthology)
Diseasesmoking status measurement, carotid artery intima media thickness

DIP2C IRX3

1.75e-0348382EFO_0006527, EFO_0007117
Diseaselow density lipoprotein cholesterol measurement, physical activity

C2CD2 HPR

3.29e-0366382EFO_0003940, EFO_0004611
Diseasebreast size

PTPN4 SPAG17

3.59e-0369382EFO_0004884

Protein segments in the cluster

PeptideGeneStartEntry
GIRKKLKPPTPWGFT

ARAP3

1281

Q8WWN8
AAPPKAVLKLEPPWI

FCGR2A

36

P12318
WPAPVTKQPDIKNPK

FLRT3

381

Q9NZU0
APQSPPAVKAKPKWQ

RAPH1

891

Q70E73
PAVKAKPKWQPSSIP

RAPH1

896

Q70E73
KPPALPPKQSKKNSW

PTPN4

461

P29074
APKGPKLPHAPPWVK

ANKRD34B

236

A5PLL1
KNTVLLTWKPPEPAP

OBSL1

531

O75147
PKPITVWKGIPQAPQ

MMP24

511

Q9Y5R2
PVKKTLITPGPWKVP

MAGI3

1451

Q5TCQ9
KVPPTPPEKTWVRKP

KIAA1671

266

Q9BY89
PKWKAPKSPVGVQPI

HPR

261

P00739
PKPISVWQGIPASPK

MMP15

501

P51511
EKPPWLKSGKSEPKP

FSIP2

1241

Q5CZC0
PWPGKIVNPPKDLKK

GLYR1

21

Q49A26
FPCPAKGTPKPTIKW

HMCN1

1286

Q96RW7
SGIPPPNLIWKKKGS

HMCN1

2221

Q96RW7
VLGVPKAVLPKTWPQ

PLD4

266

Q96BZ4
PAQPPWRKPKTGKKG

CEFIP

376

Q711Q0
GVPVVTWPKKTPKNR

KDM2B

566

Q8NHM5
KSWPIPPPVPAAKIE

C2CD2

391

Q9Y426
KLWLFGKKPKPQSPP

FNBP1L

321

Q5T0N5
KSPTGEIPQFKGWPK

DIP2C

451

Q9Y2E4
APKAPRPKWPKVNGK

BAHD1

241

Q8TBE0
PIFGKWSQVAPPVLK

EMC1

606

Q8N766
WKPKKARLKKPGPPW

DCBLD2

326

Q96PD2
PAPAPASALQKPKIW

IRX3

336

P78415
DIVPKSVWKPPPVIP

RSPH6A

401

Q9H0K4
VPPWAPPKQPILKTV

MRPL45

266

Q9BRJ2
KEGKPKTIIVNWQPP

NEO1

966

Q92859
SWKDGNPLKKPPPAV

SIGLEC8

421

Q9NYZ4
EKKTPGPPFGTQIWK

SPAG17

1726

Q6Q759
KANIPWKVPGLPTPI

PRPF8

721

Q6P2Q9
KVIKDLPWPPPVGQL

SHF

221

Q7M4L6
LPPGTPKAKIVVTVW

TRAPPC14

161

Q8WVR3
VKKKRQSWFPPPPPG

SCEL

156

O95171
KSKVWKSNPPGLGVP

SEPTIN12

71

Q8IYM1
KQEPIKPSAVWPQPT

ZNF366

151

Q8N895
EVPSIKPPSWKVPDQ

VSIG10L

51

Q86VR7
KVPSPPPGHKWKEVR

TOP1

391

P11387
ELWKVPLPPKNITAP

TNRC6A

1716

Q8NDV7