Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctiongated channel activity

ANO2 ANO9 TMC7 RASA3 ANO1 TMC4 CLCN2 KCNQ5 KCNK10 TMEM38A ANO7

8.27e-073349911GO:0022836
GeneOntologyMolecularFunctionprotein phosphatase activator activity

PPP2R5A PPP2R5B PPP2R5C PPP2R5D

1.29e-0617994GO:0072542
GeneOntologyMolecularFunctionintracellularly calcium-gated channel activity

ANO2 ANO9 ANO1 ANO7

2.59e-0620994GO:0141147
GeneOntologyMolecularFunctionintracellularly calcium-gated chloride channel activity

ANO2 ANO9 ANO1 ANO7

2.59e-0620994GO:0005229
GeneOntologyMolecularFunctionphosphatase activator activity

PPP2R5A PPP2R5B PPP2R5C PPP2R5D

2.59e-0620994GO:0019211
GeneOntologyMolecularFunctiontransporter activity

ANO2 ANO9 TMC7 SLC2A8 RASA3 SLC22A15 ANO1 APOB TMC4 SLC22A24 SLC9A1 CLCN2 KCNQ5 SLCO1A2 KCNK10 TMEM38A ANO7 ATP6V0D2 SLC23A2 SLC39A7

4.33e-0612899920GO:0005215
GeneOntologyMolecularFunctiontransmembrane transporter activity

ANO2 ANO9 TMC7 SLC2A8 RASA3 SLC22A15 ANO1 TMC4 SLC22A24 SLC9A1 CLCN2 KCNQ5 SLCO1A2 KCNK10 TMEM38A ANO7 ATP6V0D2 SLC23A2 SLC39A7

4.61e-0611809919GO:0022857
GeneOntologyMolecularFunctionphospholipid scramblase activity

ANO2 ANO9 ANO1 ANO7

4.68e-0623994GO:0017128
GeneOntologyMolecularFunctionmonoatomic ion transmembrane transporter activity

ANO2 ANO9 TMC7 RASA3 ANO1 TMC4 SLC9A1 CLCN2 KCNQ5 KCNK10 TMEM38A ANO7 ATP6V0D2 SLC23A2 SLC39A7

8.13e-067939915GO:0015075
GeneOntologyMolecularFunctionmonoatomic ion channel activity

ANO2 ANO9 TMC7 RASA3 ANO1 TMC4 CLCN2 KCNQ5 KCNK10 TMEM38A ANO7

1.72e-054599911GO:0005216
GeneOntologyMolecularFunctionchannel activity

ANO2 ANO9 TMC7 RASA3 ANO1 TMC4 CLCN2 KCNQ5 KCNK10 TMEM38A ANO7

5.84e-055259911GO:0015267
GeneOntologyMolecularFunctionpassive transmembrane transporter activity

ANO2 ANO9 TMC7 RASA3 ANO1 TMC4 CLCN2 KCNQ5 KCNK10 TMEM38A ANO7

5.94e-055269911GO:0022803
GeneOntologyMolecularFunctionchloride channel activity

ANO2 ANO9 ANO1 CLCN2 ANO7

6.86e-0586995GO:0005254
GeneOntologyMolecularFunctioninorganic molecular entity transmembrane transporter activity

ANO2 ANO9 RASA3 ANO1 SLC9A1 CLCN2 KCNQ5 KCNK10 TMEM38A ANO7 ATP6V0D2 SLC23A2 SLC39A7

9.35e-057589913GO:0015318
GeneOntologyMolecularFunctionligand-gated monoatomic anion channel activity

ANO2 ANO9 ANO1 ANO7

1.10e-0450994GO:0099095
GeneOntologyMolecularFunctionintramembrane lipid transporter activity

ANO2 ANO9 ANO1 ANO7

1.19e-0451994GO:0140303
GeneOntologyMolecularFunctionmonoatomic anion channel activity

ANO2 ANO9 ANO1 CLCN2 ANO7

1.61e-04103995GO:0005253
GeneOntologyMolecularFunctionchloride transmembrane transporter activity

ANO2 ANO9 ANO1 CLCN2 ANO7

3.97e-04125995GO:0015108
GeneOntologyMolecularFunctionligand-gated monoatomic ion channel activity

ANO2 ANO9 RASA3 ANO1 TMEM38A ANO7

4.01e-04193996GO:0015276
GeneOntologyMolecularFunctionlipid transporter activity

ANO2 ANO9 ANO1 APOB SLCO1A2 ANO7

4.35e-04196996GO:0005319
GeneOntologyMolecularFunctionligand-gated channel activity

ANO2 ANO9 RASA3 ANO1 TMEM38A ANO7

4.47e-04197996GO:0022834
GeneOntologyMolecularFunctionphospholipid transporter activity

ANO2 ANO9 ANO1 ANO7

5.01e-0474994GO:0005548
GeneOntologyMolecularFunctionATP-dependent chromatin remodeler activity

SMARCA5 SMARCA1 CHD6

8.13e-0437993GO:0140658
GeneOntologyMolecularFunctionmonoatomic anion transmembrane transporter activity

ANO2 ANO9 ANO1 CLCN2 ANO7

9.35e-04151995GO:0008509
GeneOntologyMolecularFunctionvoltage-gated chloride channel activity

ANO1 CLCN2

1.30e-0311992GO:0005247
GeneOntologyMolecularFunctionprotein phosphatase regulator activity

PPP2R5A PPP2R5B PPP2R5C PPP2R5D

1.55e-03100994GO:0019888
GeneOntologyMolecularFunctioninorganic anion transmembrane transporter activity

ANO2 ANO9 ANO1 CLCN2 ANO7

1.62e-03171995GO:0015103
GeneOntologyMolecularFunctionretinoic acid 4-hydroxylase activity

CYP26B1 CYP3A5

2.13e-0314992GO:0008401
GeneOntologyMolecularFunctionphosphatase regulator activity

PPP2R5A PPP2R5B PPP2R5C PPP2R5D

2.42e-03113994GO:0019208
GeneOntologyMolecularFunctionoxidoreductase activity, acting on CH or CH2 groups

CYP3A5 XDH

2.45e-0315992GO:0016725
GeneOntologyMolecularFunctionvoltage-gated monoatomic anion channel activity

ANO1 CLCN2

3.15e-0317992GO:0008308
GeneOntologyMolecularFunctionmechanosensitive monoatomic ion channel activity

TMC7 TMC4

3.54e-0318992GO:0008381
GeneOntologyMolecularFunctionphosphatidylethanolamine binding

GABARAPL1 GABARAPL3

3.94e-0319992GO:0008429
GeneOntologyMolecularFunctionGABA receptor binding

GABARAPL1 GABARAPL3

4.36e-0320992GO:0050811
GeneOntologyMolecularFunctionenzyme activator activity

RASA3 GMIP PPP2R5A PPP2R5B PPP2R5C PPP2R5D ARHGEF1 ARHGAP27 GCN1

5.28e-03656999GO:0008047
GeneOntologyMolecularFunctionmonoatomic cation transmembrane transporter activity

RASA3 ANO1 SLC9A1 KCNQ5 KCNK10 TMEM38A ATP6V0D2 SLC23A2 SLC39A7

5.71e-03664999GO:0008324
GeneOntologyBiologicalProcesscellular response to phenylpropanoid

UGT3A1 UGT3A2

2.23e-052982GO:1905546
GeneOntologyBiologicalProcesscellular response to hydroxyisoflavone

UGT3A1 UGT3A2

2.23e-052982GO:0071413
GeneOntologyBiologicalProcesscellular response to genistein

UGT3A1 UGT3A2

2.23e-052982GO:0071412
GeneOntologyBiologicalProcessresponse to genistein

UGT3A1 UGT3A2

6.68e-053982GO:0033595
GeneOntologyBiologicalProcesscalcium activated phosphatidylserine scrambling

ANO9 ANO7

1.33e-044982GO:0061589
GeneOntologyBiologicalProcesschloride transmembrane transport

ANO2 ANO9 ANO1 CLCN2 ANO7

1.96e-04112985GO:1902476
GeneOntologyBiologicalProcesscalcium activated phospholipid scrambling

ANO9 ANO7

2.21e-045982GO:0061588
GeneOntologyBiologicalProcesscalcium activated phosphatidylcholine scrambling

ANO9 ANO7

2.21e-045982GO:0061590
GeneOntologyBiologicalProcesscalcium activated galactosylceramide scrambling

ANO9 ANO7

2.21e-045982GO:0061591
GeneOntologyBiologicalProcessresponse to hydroxyisoflavone

UGT3A1 UGT3A2

2.21e-045982GO:0033594
GeneOntologyBiologicalProcessmonoatomic ion transport

ANO2 ANO9 TMC7 SLC22A15 ANO1 TMC4 SLC22A24 SLC9A1 CLCN2 KCNQ5 SLCO1A2 KCNK10 TMEM38A ANO7 ATP6V0D2 SLC23A2 SLC39A7

2.40e-0413749817GO:0006811
GeneOntologyBiologicalProcessmonoatomic anion transport

ANO2 ANO9 ANO1 CLCN2 SLCO1A2 ANO7

2.41e-04183986GO:0006820
GeneOntologyBiologicalProcessresponse to phenylpropanoid

UGT3A1 UGT3A2

3.31e-046982GO:0080184
GeneOntologyBiologicalProcesschloride transport

ANO2 ANO9 ANO1 CLCN2 ANO7

3.64e-04128985GO:0006821
GeneOntologyCellularComponentprotein phosphatase type 2A complex

PPP2R5A PPP2R5B PPP2R5C PPP2R5D

1.43e-06181004GO:0000159
GeneOntologyCellularComponentUDP-N-acetylglucosamine transferase complex

UGT3A1 UGT3A2

1.35e-0441002GO:0043541
GeneOntologyCellularComponentphosphatase complex

PPP2R5A PPP2R5B PPP2R5C PPP2R5D

1.39e-04551004GO:1903293
GeneOntologyCellularComponentprotein serine/threonine phosphatase complex

PPP2R5A PPP2R5B PPP2R5C PPP2R5D

1.39e-04551004GO:0008287
GeneOntologyCellularComponentNURF complex

SMARCA5 SMARCA1

4.68e-0471002GO:0016589
DomainPP2A_B56

PPP2R5A PPP2R5B PPP2R5C PPP2R5D

3.40e-095974IPR002554
DomainB56

PPP2R5A PPP2R5B PPP2R5C PPP2R5D

3.40e-095974PF01603
DomainAnoctamin

ANO2 ANO9 ANO1 ANO7

1.40e-0710974PF04547
DomainAnoctamin

ANO2 ANO9 ANO1 ANO7

1.40e-0710974IPR007632
DomainARM-type_fold

APOB WDFY4 URB1 THADA PPP2R5A PPP2R5B PPP2R5C PPP2R5D PRKDC LRBA GCN1 STAG3

1.88e-073399712IPR016024
DomainAnoct_dimer

ANO2 ANO1 ANO7

4.68e-067973PF16178
DomainAnoct_dimer

ANO2 ANO1 ANO7

4.68e-067973IPR032394
DomainSLIDE

SMARCA5 SMARCA1

2.67e-052972IPR015195
DomainISWI_HAND-dom

SMARCA5 SMARCA1

2.67e-052972IPR015194
DomainSLIDE

SMARCA5 SMARCA1

2.67e-052972PF09111
DomainHAND

SMARCA5 SMARCA1

2.67e-052972PF09110
DomainISWI

SMARCA5 SMARCA1

2.67e-052972IPR029915
DomainDBINO

SMARCA5 SMARCA1

7.98e-053972PF13892
DomainDBINO

SMARCA5 SMARCA1

7.98e-053972IPR020838
DomainARM-like

WDFY4 PPP2R5A PPP2R5C PRKDC LRBA GCN1 STAG3

5.18e-04270977IPR011989
DomainSNF2_N

SMARCA5 SMARCA1 CHD6

6.04e-0432973IPR000330
DomainSNF2_N

SMARCA5 SMARCA1 CHD6

6.04e-0432973PF00176
DomainPH-BEACH_dom

WDFY4 LRBA

7.32e-048972IPR023362
DomainAtg8

GABARAPL1 GABARAPL3

7.32e-048972PF02991
Domain-

WDFY4 LRBA

7.32e-0489722.30.29.40
DomainTMC

TMC7 TMC4

7.32e-048972PF07810
DomainAtg8-like

GABARAPL1 GABARAPL3

7.32e-048972IPR004241
DomainPH_BEACH

WDFY4 LRBA

7.32e-048972PS51783
DomainTMC

TMC7 TMC4

7.32e-048972IPR012496
DomainBEACH_dom

WDFY4 LRBA

9.39e-049972IPR000409
DomainBEACH

WDFY4 LRBA

9.39e-049972PS50197
DomainBeach

WDFY4 LRBA

9.39e-049972PF02138
Domain-

WDFY4 LRBA

9.39e-0499721.10.1540.10
DomainBeach

WDFY4 LRBA

9.39e-049972SM01026
DomainDEAH_ATP_HELICASE

SMARCA5 SMARCA1 CHD6

1.00e-0338973PS00690
Domain-

WDFY4 PPP2R5C PRKDC LRBA GCN1 STAG3

1.06e-032229761.25.10.10
DomainUBX

UBXN6 UBXN2B

1.70e-0312972SM00166
DomainUBX

UBXN6 UBXN2B

2.01e-0313972PF00789
DomainUBX

UBXN6 UBXN2B

2.01e-0313972PS50033
DomainUBX_dom

UBXN6 UBXN2B

2.01e-0313972IPR001012
DomainSANT

SMARCA5 SMARCA1 CHD6

2.23e-0350973SM00717
DomainMFS

SLC2A8 SLC22A15 SLC22A24 SLCO1A2

2.43e-03108974PS50850
DomainSANT/Myb

SMARCA5 SMARCA1 CHD6

2.50e-0352973IPR001005
DomainMFS_dom

SLC2A8 SLC22A15 SLC22A24 SLCO1A2

5.25e-03134974IPR020846
DomainUDPGT

UGT3A1 UGT3A2

5.26e-0321972PF00201
DomainUDPGT

UGT3A1 UGT3A2

5.26e-0321972PS00375
DomainUDP_glucos_trans

UGT3A1 UGT3A2

5.26e-0321972IPR002213
DomainPH_dom-like

PSD2 RASA3 EPB41L3 WDFY4 ARHGEF1 ARHGAP27 LRBA

6.76e-03426977IPR011993
DomainSANT_dom

SMARCA5 SMARCA1

8.00e-0326972IPR017884
DomainSANT

SMARCA5 SMARCA1

9.24e-0328972PS51293
DomainZnF_U1

ZNF385D ZFHX3

9.89e-0329972SM00451
DomainZnf_U1

ZNF385D ZFHX3

9.89e-0329972IPR003604
PathwayREACTOME_SIGNALING_BY_CTNNB1_PHOSPHO_SITE_MUTANTS

AMER1 PPP2R5A PPP2R5B PPP2R5C PPP2R5D

1.15e-0815765M27407
PathwayREACTOME_PLATELET_SENSITIZATION_BY_LDL

APOB PPP2R5A PPP2R5B PPP2R5C PPP2R5D

2.34e-0817765MM15096
PathwayREACTOME_BETA_CATENIN_PHOSPHORYLATION_CASCADE

AMER1 PPP2R5A PPP2R5B PPP2R5C PPP2R5D

2.34e-0817765M27083
PathwayREACTOME_PLATELET_SENSITIZATION_BY_LDL

APOB PPP2R5A PPP2R5B PPP2R5C PPP2R5D

2.34e-0817765M919
PathwayREACTOME_BETA_CATENIN_PHOSPHORYLATION_CASCADE

AMER1 PPP2R5A PPP2R5B PPP2R5C PPP2R5D

3.23e-0818765MM14759
PathwayREACTOME_INDUCTION_OF_CELL_CELL_FUSION

ANO2 ANO9 ANO1 ANO7

5.38e-0713764M46426
PathwayREACTOME_DISASSEMBLY_OF_THE_DESTRUCTION_COMPLEX_AND_RECRUITMENT_OF_AXIN_TO_THE_MEMBRANE

AMER1 PPP2R5A PPP2R5B PPP2R5C PPP2R5D

6.07e-0731765M27400
PathwayREACTOME_DISASSEMBLY_OF_THE_DESTRUCTION_COMPLEX_AND_RECRUITMENT_OF_AXIN_TO_THE_MEMBRANE

AMER1 PPP2R5A PPP2R5B PPP2R5C PPP2R5D

6.07e-0731765MM15154
PathwayWP_COHESIN_COMPLEX_CORNELIA_DE_LANGE_SYNDROME

PPP2R5A PPP2R5B PPP2R5C PPP2R5D STAG3

9.82e-0734765M42555
PathwayREACTOME_SIGNALING_BY_WNT_IN_CANCER

AMER1 PPP2R5A PPP2R5B PPP2R5C PPP2R5D

9.82e-0734765M27405
PathwayKEGG_MEDICUS_REFERENCE_COHESIN_DISSOCIATION_IN_PROPHASE

PPP2R5A PPP2R5B PPP2R5C PPP2R5D

1.35e-0616764M47870
PathwayKEGG_MEDICUS_REFERENCE_PP2A_AKT_SIGNALING_PATHWAY

PPP2R5A PPP2R5B PPP2R5C PPP2R5D

2.84e-0619764M47525
PathwayKEGG_MEDICUS_REFERENCE_CONDENSIN_LOADING

PPP2R5A PPP2R5B PPP2R5C PPP2R5D

3.54e-0620764M47876
PathwayREACTOME_CTLA4_INHIBITORY_SIGNALING

PPP2R5A PPP2R5B PPP2R5C PPP2R5D

4.35e-0621764M5876
PathwayREACTOME_CTLA4_INHIBITORY_SIGNALING

PPP2R5A PPP2R5B PPP2R5C PPP2R5D

4.35e-0621764MM14996
PathwayKEGG_MEDICUS_REFERENCE_CD80_CD86_CTLA4_PP2A_SIGNALING_PATHWAY

PPP2R5A PPP2R5B PPP2R5C PPP2R5D

5.30e-0622764M47919
PathwayREACTOME_RAF_ACTIVATION

PPP2R5A PPP2R5B PPP2R5C PPP2R5D

3.20e-0534764M27556
PathwayWP_GLYCOGEN_METABOLISM

PPP2R5A PPP2R5B PPP2R5C PPP2R5D

3.20e-0534764MM15985
PathwayREACTOME_RAF_ACTIVATION

PPP2R5A PPP2R5B PPP2R5C PPP2R5D

3.60e-0535764MM15271
PathwayREACTOME_PLATELET_HOMEOSTASIS

APOB PPP2R5A PPP2R5B PPP2R5C PPP2R5D

5.46e-0576765MM15051
PathwayWP_GLYCOGEN_SYNTHESIS_AND_DEGRADATION

PPP2R5A PPP2R5B PPP2R5C PPP2R5D

6.15e-0540764M39595
PathwayREACTOME_TRANSPORT_OF_SMALL_MOLECULES

ANO2 ANO9 SLC2A8 SLC22A15 ANO1 APOB SLC9A1 LMF2 CLCN2 SLCO1A2 ANO7 ATP6V0D2 SLC39A7

6.37e-056817613MM14985
PathwayREACTOME_DEGRADATION_OF_BETA_CATENIN_BY_THE_DESTRUCTION_COMPLEX

AMER1 PPP2R5A PPP2R5B PPP2R5C PPP2R5D

6.58e-0579765MM14754
PathwayREACTOME_NEGATIVE_REGULATION_OF_MAPK_PATHWAY

PPP2R5A PPP2R5B PPP2R5C PPP2R5D

7.47e-0542764MM15274
PathwayREACTOME_NEGATIVE_REGULATION_OF_MAPK_PATHWAY

PPP2R5A PPP2R5B PPP2R5C PPP2R5D

8.21e-0543764M27560
PathwayREACTOME_DEGRADATION_OF_BETA_CATENIN_BY_THE_DESTRUCTION_COMPLEX

AMER1 PPP2R5A PPP2R5B PPP2R5C PPP2R5D

9.34e-0585765M27079
PathwayREACTOME_PLATELET_HOMEOSTASIS

APOB PPP2R5A PPP2R5B PPP2R5C PPP2R5D

9.88e-0586765M916
PathwayREACTOME_TRANSPORT_OF_SMALL_MOLECULES

ANO2 ANO9 SLC2A8 SLC22A15 ANO1 APOB SLC9A1 LMF2 CLCN2 SLCO1A2 ANO7 ATP6V0D2 SLC39A7

1.39e-047367613M27287
PathwayREACTOME_STIMULI_SENSING_CHANNELS

ANO2 ANO9 ANO1 CLCN2 ANO7

1.92e-0499765MM14910
PathwayREACTOME_AMPLIFICATION_OF_SIGNAL_FROM_THE_KINETOCHORES

NUP85 PPP2R5A PPP2R5B PPP2R5C PPP2R5D

2.01e-04100765MM14561
PathwayWP_IL6_SIGNALING_PATHWAY

MAP3K4 PPP2R5A PPP2R5B PPP2R5C PPP2R5D

2.01e-04100765MM15826
PathwayREACTOME_STIMULI_SENSING_CHANNELS

ANO2 ANO9 ANO1 CLCN2 ANO7

2.64e-04106765M27200
PathwayREACTOME_MITOTIC_SPINDLE_CHECKPOINT

NUP85 PPP2R5A PPP2R5B PPP2R5C PPP2R5D

3.27e-04111765M27673
PathwayKEGG_OOCYTE_MEIOSIS

PPP2R5A PPP2R5B PPP2R5C PPP2R5D STAG3

3.56e-04113765M16817
PathwayREACTOME_NEGATIVE_REGULATION_OF_THE_PI3K_AKT_NETWORK

PPP2R5A PPP2R5B PPP2R5C PPP2R5D IRAK4

3.56e-04113765MM14783
PathwayREACTOME_ION_CHANNEL_TRANSPORT

ANO2 ANO9 ANO1 CLCN2 ANO7 ATP6V0D2

3.69e-04176766MM15718
PathwayREACTOME_MITOTIC_SPINDLE_CHECKPOINT

NUP85 PPP2R5A PPP2R5B PPP2R5C PPP2R5D

4.18e-04117765MM15387
PathwayREACTOME_NEGATIVE_REGULATION_OF_THE_PI3K_AKT_NETWORK

PPP2R5A PPP2R5B PPP2R5C PPP2R5D IRAK4

4.34e-04118765M713
PathwayREACTOME_COSTIMULATION_BY_THE_CD28_FAMILY

PPP2R5A PPP2R5B PPP2R5C PPP2R5D

4.37e-0466764MM14990
PathwayREACTOME_DRUG_ADME

CYP3A5 UGT3A1 XDH SLCO1A2 UGT3A2

4.51e-04119765MM15692
PathwayREACTOME_ION_CHANNEL_TRANSPORT

ANO2 ANO9 ANO1 CLCN2 ANO7 ATP6V0D2

4.54e-04183766M997
PathwayREACTOME_LATE_SARS_COV_2_INFECTION_EVENTS

ANO2 ANO9 ANO1 ANO7

5.46e-0470764M46438
PathwayREACTOME_RESOLUTION_OF_SISTER_CHROMATID_COHESION

NUP85 PPP2R5A PPP2R5B PPP2R5C PPP2R5D

6.08e-04127765M27181
PathwayREACTOME_RESOLUTION_OF_SISTER_CHROMATID_COHESION

NUP85 PPP2R5A PPP2R5B PPP2R5C PPP2R5D

6.52e-04129765MM14894
PathwayREACTOME_COSTIMULATION_BY_THE_CD28_FAMILY

PPP2R5A PPP2R5B PPP2R5C PPP2R5D

6.75e-0474764M17386
PathwayREACTOME_RHO_GTPASES_ACTIVATE_FORMINS

NUP85 PPP2R5A PPP2R5B PPP2R5C PPP2R5D

9.44e-04140765M27550
PathwayREACTOME_RHO_GTPASES_ACTIVATE_FORMINS

NUP85 PPP2R5A PPP2R5B PPP2R5C PPP2R5D

9.75e-04141765MM15266
PathwayREACTOME_TCF_DEPENDENT_SIGNALING_IN_RESPONSE_TO_WNT

AMER1 PPP2R5A PPP2R5B PPP2R5C PPP2R5D

1.62e-03158765MM14791
PathwayREACTOME_ASPIRIN_ADME

CYP3A5 UGT3A1 UGT3A2

1.82e-0345763MM15694
PathwayREACTOME_DRUG_ADME

UGT3A1 XDH SLCO1A2 UGT3A2

2.83e-03109764M45012
Pubmed

Protein phosphatase 2A protects centromeric sister chromatid cohesion during meiosis I.

PPP2R5A PPP2R5B PPP2R5C PPP2R5D PRKDC

1.46e-1012101516541024
Pubmed

Assignment of human protein phosphatase 2A regulatory subunit genes b56alpha, b56beta, b56gamma, b56delta, and b56epsilon (PPP2R5A-PPP2R5E), highly expressed in muscle and brain, to chromosome regions 1q41, 11q12, 3p21, 6p21.1, and 7p11.2 --> p12.

PPP2R5A PPP2R5B PPP2R5C PPP2R5D

3.34e-10510148812429
Pubmed

Genomic organisation, chromosomal localisation tissue distribution and developmental regulation of the PR61/B' regulatory subunits of protein phosphatase 2A in mice.

PPP2R5A PPP2R5B PPP2R5C PPP2R5D

3.34e-105101415095873
Pubmed

The B56 family of protein phosphatase 2A (PP2A) regulatory subunits encodes differentiation-induced phosphoproteins that target PP2A to both nucleus and cytoplasm.

PPP2R5A PPP2R5B PPP2R5C PPP2R5D

2.33e-09710148703017
Pubmed

Identification of a new family of protein phosphatase 2A regulatory subunits.

PPP2R5A PPP2R5B PPP2R5C PPP2R5D

2.33e-09710147592815
Pubmed

The anoctamin family: TMEM16A and TMEM16B as calcium-activated chloride channels.

ANO2 ANO9 ANO1 ANO7

4.65e-098101421984732
Pubmed

Expression and function of epithelial anoctamins.

ANO2 ANO9 ANO1 ANO7

4.65e-098101420056604
Pubmed

Direct binding between BubR1 and B56-PP2A phosphatase complexes regulate mitotic progression.

PPP2R5A PPP2R5B PPP2R5C PPP2R5D

8.35e-099101423345399
Pubmed

De Novo Mutations Affecting the Catalytic Cα Subunit of PP2A, PPP2CA, Cause Syndromic Intellectual Disability Resembling Other PP2A-Related Neurodevelopmental Disorders.

PPP2R5A PPP2R5B PPP2R5C PPP2R5D

8.35e-099101430595372
Pubmed

Anoctamin/TMEM16 family members are Ca2+-activated Cl- channels.

ANO2 ANO9 ANO1 ANO7

1.39e-0810101419015192
Pubmed

Calcium-dependent phospholipid scramblase activity of TMEM16 protein family members.

ANO2 ANO9 ANO1 ANO7

1.39e-0810101423532839
Pubmed

Structure and function of TMEM16 proteins (anoctamins).

ANO2 ANO9 ANO1 ANO7

1.39e-0810101424692353
Pubmed

Mutations in the PP2A regulatory subunit B family genes PPP2R5B, PPP2R5C and PPP2R5D cause human overgrowth.

PPP2R5B PPP2R5C PPP2R5D

2.38e-083101325972378
Pubmed

Regulation of Chk2 phosphorylation by interaction with protein phosphatase 2A via its B' regulatory subunit.

PPP2R5A PPP2R5B PPP2R5C PPP2R5D

3.26e-0812101415380617
Pubmed

PP2A1 binding, cell transducing and apoptotic properties of Vpr(77-92): a new functional domain of HIV-1 Vpr proteins.

PPP2R5A PPP2R5B PPP2R5C PPP2R5D

4.69e-0813101421072166
Pubmed

Direct activation of protein phosphatase-2A0 by HIV-1 encoded protein complex NCp7:vpr.

PPP2R5A PPP2R5B PPP2R5C PPP2R5D

6.56e-081410149013886
Pubmed

Increasing the ratio of PP2A core enzyme to holoenzyme inhibits Tat-stimulated HIV-1 transcription and virus production.

PPP2R5A PPP2R5B PPP2R5C PPP2R5D

6.56e-081410149400615
Pubmed

Dephosphorylation of CDK9 by protein phosphatase 2A and protein phosphatase-1 in Tat-activated HIV-1 transcription.

PPP2R5A PPP2R5B PPP2R5C PPP2R5D

6.56e-0814101416048649
Pubmed

Regulation of HIV-1 transcription by protein phosphatase 1.

PPP2R5A PPP2R5B PPP2R5C PPP2R5D

1.55e-0717101417266553
Pubmed

[Action of protein phosphatase-1 on Tat-dependent HIV-1 transcription and its related inhibitors].

PPP2R5A PPP2R5B PPP2R5C PPP2R5D

1.55e-0717101421351466
Pubmed

Molecular mechanisms involved in HIV-1-Tat mediated inhibition of telomerase activity in human CD4(+) T lymphocytes.

PPP2R5A PPP2R5B PPP2R5C PPP2R5D

1.99e-0718101423287597
Pubmed

The variable subunit associated with protein phosphatase 2A0 defines a novel multimember family of regulatory subunits.

PPP2R5A PPP2R5B PPP2R5C

2.37e-07510138694763
Pubmed

Shugoshin collaborates with protein phosphatase 2A to protect cohesin.

PPP2R5A PPP2R5B PPP2R5C PPP2R5D

2.51e-0719101416541025
Pubmed

ANOs 3-7 in the anoctamin/Tmem16 Cl- channel family are intracellular proteins.

ANO2 ANO1 ANO7

8.25e-077101322075693
Pubmed

HIV-1 Vpr induces cell cycle G2 arrest in fission yeast (Schizosaccharomyces pombe) through a pathway involving regulatory and catalytic subunits of PP2A and acting on both Wee1 and Cdc25.

PPP2R5A PPP2R5B PPP2R5C PPP2R5D

9.53e-0726101411531413
Pubmed

Expression of TMEM16 paralogs during murine embryogenesis.

ANO2 ANO9 ANO1

1.32e-068101318729231
Pubmed

Anoctamins are a family of Ca2+-activated Cl- channels.

ANO9 ANO1 ANO7

1.32e-068101322946059
Pubmed

Bromodomain protein Brd4 regulates human immunodeficiency virus transcription through phosphorylation of CDK9 at threonine 29.

PPP2R5B PPP2R5C PPP2R5D

6.66e-0613101318971272
Pubmed

TMEM16A-TMEM16B chimaeras to investigate the structure-function relationship of calcium-activated chloride channels.

ANO2 ANO1

8.35e-062101223570556
Pubmed

Developmental expression of the calcium-activated chloride channels TMEM16A and TMEM16B in the mouse olfactory epithelium.

ANO2 ANO1

8.35e-062101224318978
Pubmed

Calcium-activated chloride channels anoctamin 1 and 2 promote murine uterine smooth muscle contractility.

ANO2 ANO1

8.35e-062101224928056
Pubmed

Identification of residues that confer sugar selectivity to UDP-glycosyltransferase 3A (UGT3A) enzymes.

UGT3A1 UGT3A2

8.35e-062101222621930
Pubmed

The Cl--channel TMEM16A is involved in the generation of cochlear Ca2+ waves and promotes the refinement of auditory brainstem networks in mice.

ANO2 ANO1

8.35e-062101235129434
Pubmed

Preassociated apocalmodulin mediates Ca2+-dependent sensitization of activation and inactivation of TMEM16A/16B Ca2+-gated Cl- channels.

ANO2 ANO1

8.35e-062101225489088
Pubmed

Calcium-activated chloride channels (CaCCs) regulate action potential and synaptic response in hippocampal neurons.

ANO2 ANO1

8.35e-062101222500639
Pubmed

A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein.

PPP2R5A PPP2R5B PPP2R5C PPP2R5D

9.95e-0646101418782753
Pubmed

RBR-type E3 ubiquitin ligase RNF144A targets PARP1 for ubiquitin-dependent degradation and regulates PARP inhibitor sensitivity in breast cancer cells.

CD109 EPB41L3 SVIL GCN1

1.09e-0547101429212245
Pubmed

Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB.

AMER1 MYH13 APOB EPB41L3 THADA ZFHX3 PRKDC LRBA SCLT1 GCN1 SDK1

1.65e-057771011135844135
Pubmed

Binding kinetics of human ISWI chromatin-remodelers to DNA repair sites elucidate their target location mechanism.

SMARCA5 SMARCA1

2.50e-053101221738833
Pubmed

Cloning and characterization of the murine Imitation Switch (ISWI) genes: differential expression patterns suggest distinct developmental roles for Snf2h and Snf2l.

SMARCA5 SMARCA1

2.50e-053101211359880
Pubmed

Identification of a dimerization domain in the TMEM16A calcium-activated chloride channel (CaCC).

ANO2 ANO1

2.50e-053101223576756
Pubmed

TMEM16A and TMEM16B Modulate Pheromone-Evoked Action Potential Firing in Mouse Vomeronasal Sensory Neurons.

ANO2 ANO1

2.50e-053101234433575
Pubmed

The Balpha and Bdelta regulatory subunits of PP2A are necessary for assembly of the CaMKIV.PP2A signaling complex.

PPP2R5A PPP2R5D

2.50e-053101219538941
Pubmed

Anoctamin Calcium-Activated Chloride Channels May Modulate Inhibitory Transmission in the Cerebellar Cortex.

ANO2 ANO1

2.50e-053101226558388
Pubmed

Putative pore-loops of TMEM16/anoctamin channels affect channel density in cell membranes.

ANO2 ANO1

2.50e-053101223613533
Pubmed

Expression patterns of anoctamin 1 and anoctamin 2 chloride channels in the mammalian nose.

ANO2 ANO1

2.50e-053101222314846
Pubmed

Expression of the B56delta subunit of protein phosphatase 2A and Mea1 in mouse spermatogenesis. Identification of a new B56gamma subunit (B56gamma4) specifically expressed in testis.

PPP2R5C PPP2R5D

2.50e-053101215051958
Pubmed

Ca2+-activated Cl- currents in the murine vomeronasal organ enhance neuronal spiking but are dispensable for male-male aggression.

ANO2 ANO1

2.50e-053101229769308
Pubmed

Comparative Host Interactomes of the SARS-CoV-2 Nonstructural Protein 3 and Human Coronavirus Homologs.

EI24 APOB CERS6 URB1 SVIL SLC23A2 SLC39A7

2.62e-05296101734186245
Pubmed

Quantitative interactome proteomics identifies a proteostasis network for GABAA receptors.

UBA1 SVIL PRKDC GCN1 SLC39A7

3.33e-05125101536030824
Pubmed

Systematic Analysis of Human Protein Phosphatase Interactions and Dynamics.

RASA3 UBA1 PPP2R5A PPP2R5B PPP2R5C PPP2R5D PRKDC GCN1 SLC39A7

4.58e-05573101928330616
Pubmed

Control of mitotic exit by PP2A regulation of Cdc25C and Cdk1.

PPP2R5C PPP2R5D

4.99e-054101218056802
Pubmed

Protein phosphatase 2A holoenzyme assembly: identification of contacts between B-family regulatory and scaffolding A subunits.

PPP2R5A PPP2R5C

4.99e-054101211929880
Pubmed

Cloning, expression patterns, and chromosome localization of three human and two mouse homologues of GABA(A) receptor-associated protein.

GABARAPL1 GABARAPL3

4.99e-054101211414770
Pubmed

Critical function for the Ras-GTPase activating protein RASA3 in vertebrate erythropoiesis and megakaryopoiesis.

RASA3 PRKDC

4.99e-054101222773809
Pubmed

Defective autoimmune regulator-dependent central tolerance to myelin protein zero is linked to autoimmune peripheral neuropathy.

CD109 PRKDC

4.99e-054101222490868
Pubmed

CFTR and TMEM16A are separate but functionally related Cl- channels.

ANO9 ANO1

4.99e-054101222178883
Pubmed

FLJ10261 gene, located within the CCND1-EMS1 locus on human chromosome 11q13, encodes the eight-transmembrane protein homologous to C12orf3, C11orf25 and FLJ34272 gene products.

ANO2 ANO1

4.99e-054101212739008
Pubmed

Ca2+-activated Cl− currents are dispensable for olfaction.

ANO2 ANO1

8.30e-055101221516098
Pubmed

A PP1-PP2A phosphatase relay controls mitotic progression.

PPP2R5C PPP2R5D

8.30e-055101225487150
Pubmed

A fluid secretion pathway unmasked by acinar-specific Tmem16A gene ablation in the adult mouse salivary gland.

ANO1 CLCN2

8.30e-055101225646474
Pubmed

The tumor suppressor PP2A Abeta regulates the RalA GTPase.

PPP2R5A PPP2R5C PPP2R5D

1.11e-0432101317540176
Pubmed

Identification and characterization of TMEM16E and TMEM16F genes in silico.

ANO2 ANO1

1.24e-046101215067359
Pubmed

WSTF-ISWI chromatin remodeling complex targets heterochromatic replication foci.

SMARCA5 SMARCA1

1.24e-046101211980720
Pubmed

Bod1 regulates protein phosphatase 2A at mitotic kinetochores.

PPP2R5A PPP2R5D

1.74e-047101224157919
Pubmed

GSK-3beta-dependent phosphorylation of adenomatous polyposis coli gene product can be modulated by beta-catenin and protein phosphatase 2A complexed with Axin.

PPP2R5B PPP2R5C

1.74e-047101210698523
Pubmed

Growth arrest of PPP2R5C and PPP2R5D double knockout mice indicates a genetic interaction and conserved function for these PP2A B subunits.

PPP2R5B PPP2R5D

1.74e-047101235415460
Pubmed

KAP1 facilitates reinstatement of heterochromatin after DNA replication.

SMARCA5 URB2 NUBP2 MAP3K4 SMARCA1 ELP2 PRKDC LRBA GCN1

2.16e-04704101929955894
Pubmed

Characterization of the transmembrane channel-like (TMC) gene family: functional clues from hearing loss and epidermodysplasia verruciformis.

TMC7 TMC4

2.31e-048101212906855
Pubmed

Cyclin G2 associates with protein phosphatase 2A catalytic and regulatory B' subunits in active complexes and induces nuclear aberrations and a G1/S phase cell cycle arrest.

PPP2R5B PPP2R5C

2.31e-048101211956189
Pubmed

TMC and EVER genes belong to a larger novel family, the TMC gene family encoding transmembrane proteins.

TMC7 TMC4

2.31e-048101212812529
Pubmed

A specific PP2A regulatory subunit, B56gamma, mediates DNA damage-induced dephosphorylation of p53 at Thr55.

PPP2R5A PPP2R5C

2.31e-048101217245430
Pubmed

The protein phosphatase 2A regulatory subunits B'beta and B'delta mediate sustained TrkA neurotrophin receptor autophosphorylation and neuronal differentiation.

PPP2R5B PPP2R5D

2.31e-048101219029245
Pubmed

An atlas of genetic influences on human blood metabolites.

AOC1 CYP3A5 UGT3A1 TMC4 NUBP2

2.39e-04190101524816252
Pubmed

A BioID-Derived Proximity Interactome for SARS-CoV-2 Proteins.

EI24 URB2 RETSAT NUBP2 THADA SLC9A1 MICB LRBA SLC23A2

2.52e-04719101935337019
Pubmed

B56-containing PP2A dephosphorylate ERK and their activity is controlled by the early gene IEX-1 and ERK.

PPP2R5B PPP2R5C

2.97e-049101216456541
Pubmed

Identification of genetic variants associated with response to statin therapy.

CYP3A5 APOB

2.97e-049101219667110
Pubmed

A PHD finger of NURF couples histone H3 lysine 4 trimethylation with chromatin remodelling.

SMARCA5 SMARCA1

2.97e-049101216728976
Pubmed

Differential expansion of the N-formylpeptide receptor gene cluster in human and mouse.

FPR3 MAP3K4

2.97e-04910129722950
Pubmed

Positive regulation of Raf1-MEK1/2-ERK1/2 signaling by protein serine/threonine phosphatase 2A holoenzymes.

PPP2R5C PPP2R5D

2.97e-049101216239230
Pubmed

Distinct spatiotemporal expression of EFA6D, a guanine nucleotide exchange factor for ARF6, among the EFA6 family in mouse brain.

PSD2 GRM1

3.70e-0410101216707115
Pubmed

Systematic proteomics of the VCP-UBXD adaptor network identifies a role for UBXN10 in regulating ciliogenesis.

MYH13 NUP85 UBXN6 EPB41L3 UBXN2B

3.71e-04209101526389662
Pubmed

LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.

NUP85 CERS6 URB2 URB1 THADA LMF2 PPP2R5D ARHGEF1 PRKDC GCN1

4.22e-049421011031073040
Pubmed

Interactions of the Antiviral Factor Interferon Gamma-Inducible Protein 16 (IFI16) Mediate Immune Signaling and Herpes Simplex Virus-1 Immunosuppression.

SMARCA5 NUP85 URB2 URB1 SVIL SMARCA1

4.28e-04332101625693804
Pubmed

Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.

URB1 PCNX1 CHD6 GCN1 SLC23A2

5.19e-04225101512168954
Pubmed

Systematic analysis of human protein complexes identifies chromosome segregation proteins.

NUP85 DYNC2I1 XDH URB1 UBA1 PPP2R5A PPP2R5C PPP2R5D SVIL PRKDC GCN1

5.37e-0411551011120360068
Pubmed

Proteomics of herpes simplex virus replication compartments: association of cellular DNA replication, repair, recombination, and chromatin remodeling proteins with ICP8.

SMARCA5 PRKDC

5.41e-0412101215140983
Pubmed

A model for p53-induced apoptosis.

ANO9 EI24

5.41e-041210129305847
Pubmed

A human MAP kinase interactome.

EPB41L3 MAP3K4 SLC9A1 ARHGEF1 CHD6 PRKDC GCN1

5.54e-04486101720936779
Pubmed

Identification of motif-based interactions between SARS-CoV-2 protein domains and human peptide ligands pinpoint antiviral targets.

PSD2 MYH13 KCNQ5 ANO7 SLC39A7

6.07e-04233101537704626
Pubmed

Identification of proteins that interact with the central coiled-coil region of the human protein kinase NEK1.

PPP2R5A PPP2R5D

6.38e-0413101214690447
Pubmed

PP2A regulates BCL-2 phosphorylation and proteasome-mediated degradation at the endoplasmic reticulum.

PPP2R5C ATP6V0D2

6.38e-0413101216717086
Pubmed

Stress granules and mTOR are regulated by membrane atg8ylation during lysosomal damage.

GABARAPL1 GCN1

7.43e-0414101236179369
Pubmed

Novel Loci for metabolic networks and multi-tissue expression studies reveal genes for atherosclerosis.

APOB ZFHX3 HERC6

7.57e-0461101322916037
Pubmed

Bcl2-associated athanogene 3 interactome analysis reveals a new role in modulating proteasome activity.

UBXN6 URB2 NUBP2 UBA1 PRKDC LRBA

7.98e-04374101623824909
Pubmed

GIAT4RA functions as a tumor suppressor in non-small cell lung cancer by counteracting Uchl3-mediated deubiquitination of LSH.

UBA1 PRKDC

8.55e-0415101231417184
Pubmed

Aurora B and Cdk1 mediate Wapl activation and release of acetylated cohesin from chromosomes by phosphorylating Sororin.

PPP2R5A PPP2R5C

8.55e-0415101223901111
Pubmed

IKAP localizes to membrane ruffles with filamin A and regulates actin cytoskeleton organization and cell migration.

ELP2 PRKDC

8.55e-0415101218303054
Pubmed

Efficient transposition of the piggyBac (PB) transposon in mammalian cells and mice.

ANO2 DYNC2I1

9.76e-0416101216096065
Pubmed

TTF-1/NKX2-1 binds to DDB1 and confers replication stress resistance to lung adenocarcinomas.

SMARCA5 NUP85 ZFHX3 PRKDC

1.03e-03152101428192407
Cytoband6q24

TAAR2 GRM1

1.33e-04810126q24
GeneFamilyAnoctamins

ANO2 ANO9 ANO1 ANO7

5.04e-0810734865
GeneFamilyWD repeat domain containing|Protein phosphatase 2 regulatory subunits

PPP2R5A PPP2R5B PPP2R5C PPP2R5D

3.23e-0715734696
GeneFamilyTransmembrane channel likes

TMC7 TMC4

4.43e-0487321135
GeneFamilyWD repeat domain containing|BEACH domain containing

WDFY4 LRBA

5.68e-0497321230
GeneFamilySolute carriers

SLC2A8 SLC22A15 SLC22A24 SLC9A1 SLCO1A2 SLC23A2 SLC39A7

1.06e-03395737752
GeneFamilyUBX domain containing

UBXN6 UBXN2B

1.22e-0313732364
GeneFamilyGATA zinc finger domain containing|Myb/SANT domain containing

SMARCA5 SMARCA1 CHD6

1.28e-0353733532
GeneFamilyOlfactory receptors, family 9

OR9A4 OR9A1P

3.85e-0323732156
GeneFamilyUDP glucuronosyltransferases

UGT3A1 UGT3A2

7.37e-0332732363
ToppCellCOPD-Endothelial-VE_Peribronchial|Endothelial / Disease state, Lineage and Cell class

ANO2 MFHAS1 URB2 EPB41L3 ZNF385D MALL SVIL

3.04e-0719410178dcde77767b23e75360adb316cdccf56a00e3726
ToppCell5'-GW_trimst-2-SmallIntestine-Epithelial-mature_enterocytic|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

AOC1 CYP3A5 UGT3A1 XDH APOB MYO15B MALL

3.73e-07200101773bfdf068a8ecbefc1e6afe9686df73658ee042f
ToppCellPCW_05-06-Endothelial-Endothelial_immature-endo_immature4_(5)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

ANO2 CYP26B1 CD109 ESAM SLC22A24 ARHGAP27

4.48e-061881016b9c5d573fc5ab0f7f38c55d006f9576634b05462
ToppCellhuman_hepatoblastoma-Inflammatory_Monocytes|World / Sample and Cell Type and Tumor Cluster (all cells)

RASA3 FPR3 CD109 EPB41L3 WDFY4 ATP6V0D2

4.91e-0619110163b59bfc6c106ae8a3fbcd4a74bd128c485724921
ToppCellEnterocyte|World / shred on cell type and cluster

AOC1 CYP3A5 APOB MYO15B MALL SLC23A2

5.86e-0619710161dd980fd066aef21694395a4b69df938501d9631
ToppCell3'-Pediatric_IBD-SmallIntestine-Epithelial-mature_enterocytic|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract

AOC1 CYP3A5 XDH APOB RETSAT MALL

6.03e-0619810168fac96132663f54566136ef54b53684d31dfde32
ToppCell3'-Pediatric_IBD-SmallIntestine-Epithelial-mature_enterocytic-Enterocyte|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract

AOC1 CYP3A5 XDH APOB RETSAT MALL

6.03e-061981016c48b3f026b16d48b8eca9f74dc1e3f3f39a89322
ToppCell5'-GW_trimst-2-SmallIntestine-Epithelial-mature_enterocytic-Enterocyte|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CYP3A5 UGT3A1 XDH APOB MYO15B MALL

6.39e-0620010163e13c9a4ba99a7dfbf738b0fb63fb54b4dee5897
ToppCellkidney_cells-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_1_/_Segment_2|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

AOC1 UGT3A1 CERS6 UBA1 MALL

2.00e-05145101547a3bb973a508d3097213a2d86ad1ce697af9bae
ToppCelldroplet-Kidney-KIDNEY-30m-Epithelial-Epcam____brush_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

UGT3A1 APOB APOBEC2 A4GNT UGT3A2

3.41e-051621015de0fde4310a56dc96bfc134c44d104993526d9bc
ToppCellC_02|World / shred on cell type and cluster

CYP3A5 APOB MYO15B MALL SLC23A2

3.72e-051651015a456c2c9ffe8dc91e17cac84ba87b88e016f8e6d
ToppCellCOPD-Lymphoid-ILC_B|Lymphoid / Disease state, Lineage and Cell class

PSD2 CERS6 FRY SVIL ZFHX3

3.83e-051661015e2cad1db536d5ad5a34c337c19b5e7d1a2851552
ToppCelldroplet-Kidney-nan-18m-Epithelial-brush_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

UGT3A1 APOB APOBEC2 A4GNT UGT3A2

4.17e-051691015f00741203efa0b948db7223ee8c19bdd0918258a
ToppCellCOPD-Lymphoid-ILC_A|World / Disease state, Lineage and Cell class

LINC01619 RASA3 PPP2R5C KCNQ5 STAG3

4.92e-051751015e773e330de36f8a0aa9398a176ed7edb5599c582
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_2|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

LINC01619 ANO1 ZNF385D SVIL SDK1

5.78e-051811015153709b4dd3d81e09f251fa8765b58bed1932fda
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive|renal_medulla_nuclei / Celltypes from Cells and Nuclei per compartment and clinical group

RASA3 MFHAS1 CERS6 SVIL SDK1

6.25e-051841015d2bf0135eb56bb410997dccea39c5ede88a0617f
ToppCellControl-T_cells-CD8+_T_cells|Control / group, cell type (main and fine annotations)

LINC01619 RASA3 PPP2R5C KCNQ5 ARHGEF1

6.41e-05185101502ab64c0166c0646d1d4c6ed110ef0b75a1096d0
ToppCellLA-13._Vascular_Smooth_Muscle|LA / Chamber and Cluster_Paper

ANO1 FRY KCNQ5 SVIL SDK1

6.91e-05188101534e1b074a3995aa46ab194eb45115d76d1a5514d
ToppCellLA-13._Vascular_Smooth_Muscle|World / Chamber and Cluster_Paper

ANO1 ZNF385D FRY KCNQ5 SDK1

7.09e-0518910156b3e88751b95fc2173f2c3d5061ed632d0c5f01c
ToppCellFetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)-D150|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

SMARCA5 FRY PPP2R5A MALL LRBA

7.27e-0519010158aea807a2bcf0b653b4de6202b6ecb0f0683cc2e
ToppCellrenal_cortex_nuclei|World / Celltypes from Cells and Nuclei per compartment and clinical group

EPB41L3 SVIL LRBA SDK1 SMYD3

7.64e-051921015e8cc4d08fcfceeab75a02558817e4ccd7dbafe3a
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ANO2 TMC7 CD109 ESAM MALL

8.02e-051941015b0c15e7e4bcf30856fb628dedd7ba82df33489f5
ToppCellPCW_10-12-Endothelial-Endothelial_mature-endo_capillary_(2)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

ANO2 CYP26B1 CD109 ESAM ARHGAP27

8.41e-0519610152a2a93b89dcb98043cb1f8b422ac8c55e2edc37b
ToppCellsaliva-Severe-critical_progression_d28-40-Myeloid-Macrophage-macrophage,_alveolar-Macro_c3-EREG|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)

RASA3 FPR3 CD109 EPB41L3 ZFHX3

8.41e-05196101580264c2fbd94418f981085fed7c5bdda1e6f404c
ToppCell3'-Pediatric_IBD-SmallIntestine-Epithelial|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract

AOC1 CYP3A5 APOB TMC4 MALL

8.83e-051981015e3e2233c796d5e9051c8c1b66f70f406f048ed56
ToppCellC_01|World / shred on cell type and cluster

AOC1 CYP3A5 APOB MYO15B MALL

8.83e-05198101571d38084d09a96331877384ce6346f0de4bdcef9
ToppCell3'-Child09-12-SmallIntestine-Epithelial-mature_enterocytic-Enterocyte|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

AOC1 CYP3A5 APOB RETSAT MALL

8.83e-0519810152967fb2d94662997bfe932ac299c80d6f182fb48
ToppCell3'-Child09-12-SmallIntestine-Epithelial-mature_enterocytic|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

AOC1 CYP3A5 APOB RETSAT MALL

8.83e-051981015222a060c2c63d30da34e4b71c37aa27a048d7d09
ToppCell(4)_Endothelial_cells-(4)_Blood_vessel|(4)_Endothelial_cells / Oesophagus cell shreds on cell class (v1) and cell subclass (v1)

ESAM EPB41L3 ZNF385D FRY MALL

9.04e-051991015e24d70e79f25cdd3300bf5e2322713355264d4c5
ToppCell3'-Child04-06-SmallIntestine-Epithelial|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

AOC1 CYP3A5 APOB RETSAT MALL

9.04e-051991015ab71b312635a2b2c98d71b60a299f44bc80a3587
ToppCell3'-Child04-06-SmallIntestine-Epithelial-mature_enterocytic-Enterocyte|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

AOC1 CYP3A5 APOB RETSAT MALL

9.04e-0519910150181c13379f869be47804cdb11bbdabcd30b9b23
ToppCellCF-Myeloid-Monocyte_Macrophage|CF / Disease state, Lineage and Cell class

FPR3 CD109 CERS6 EPB41L3 ATP6V0D2

9.04e-051991015bf95eacb31a4a847350f9d6e95ca76c6b730c400
ToppCell3'-Child04-06-SmallIntestine-Epithelial-mature_enterocytic|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

AOC1 CYP3A5 APOB RETSAT MALL

9.04e-051991015ee981046217e8759610eb58a670d98f32cd83abc
ToppCellLPS_IL1RA_TNF-Endothelial-Endothelial-Alv_Cap|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

CD109 ESAM FRY PPP2R5A ARHGAP27

9.25e-052001015b7533c571eeea0cb3678e1a57d3dc036fa8d0f49
ToppCell3'-Adult-LargeIntestine-Epithelial-mature_enterocytic-Colonocyte|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

AOC1 TMC4 RETSAT MYO15B MALL

9.25e-052001015ce0c259f7fa4c0aa6d00e0bb362c029e96fce19e
ToppCellLPS_only-Endothelial-Endothelial-Artery|LPS_only / Treatment groups by lineage, cell group, cell type

CYP26B1 TMC7 CD109 ESAM FRY

9.25e-052001015b17eb1587ca86c3d40515128a00a8d8fd787fccf
DiseaseX-24544 measurement

UGT3A1 UGT3A2

6.26e-054962EFO_0800892
Diseaseurinary metabolite measurement

AOC1 CYP3A5 UGT3A1 XDH SLC22A24 SLCO1A2

1.53e-04245966EFO_0005116
Diseaseeyelid sagging measurement

ZNF385D KCNQ5 SMYD3

1.55e-0432963EFO_0009360
DiseaseX-24494 measurement

XDH SLC22A24

2.18e-047962EFO_0800889
Diseaseserum metabolite measurement

AOC1 CYP26B1 CYP3A5 UGT3A1 TAAR2 APOB TMC4 SLC22A24 SLCO1A2 ZFHX3 ELP2

2.53e-049459611EFO_0005653
Diseasepregnanediol-3-glucuronide measurement

UGT3A1 SLC22A24

2.90e-048962EFO_0800341
Diseasewhite matter hyperintensity measurement

XDH ZNF385D PPP2R5A AP5B1 MICB CHD6

4.69e-04302966EFO_0005665
DiseaseColorectal Carcinoma

SLC22A15 CD109 APOB GRM1 ZNF385D KCNQ5 ARHGEF1 SLCO1A2 UGT3A2

4.77e-04702969C0009402
Diseasecholestasis (biomarker_via_orthology)

CYP3A5 XDH SLCO1A2

5.52e-0449963DOID:13580 (biomarker_via_orthology)
Diseasefatty acid measurement

MFHAS1 APOB TMC4 GMIP ZNF385D UBXN2B UBE2QL1

5.64e-04436967EFO_0005110
Diseasepregnenediol disulfate (C21H34O8S2) measurement

UGT3A1 SLCO1A2

5.65e-0411962EFO_0800279
Diseaselevel of Ceramide (d42:2) in blood serum

APOB UBXN2B

6.77e-0412962OBA_2045186
Disease11beta-hydroxyandrosterone glucuronide measurement

XDH SLC22A24

6.77e-0412962EFO_0800573
Diseasecentral nervous system disease (implicated_via_orthology)

SMARCA5 SMARCA1

1.22e-0316962DOID:331 (implicated_via_orthology)
Diseasesphingomyelin 14:0 measurement

THADA ZFHX3

1.38e-0317962EFO_0010390
Diseasepartial epilepsy

SMARCA5 ZNF385D

1.38e-0317962EFO_0004263
Diseasemitochondrial heteroplasmy measurement

CYP26B1 OR9A1P LMF2

1.50e-0369963EFO_0600008
DiseaseCholecystitis

UBXN2B LRBA

1.73e-0319962HP_0001082
Diseasemetabolonic lactone sulfate measurement

CYP3A5 SLCO1A2

1.73e-0319962EFO_0800659
Diseaseetiocholanolone glucuronide measurement

XDH SLC22A24

1.73e-0319962EFO_0800362
Diseaseunipolar depression

MYH13 SLC2A8 RASA3 MFHAS1 ZNF385D KCNQ5 SVIL ZFHX3 ELP2 CHD6 SDK1

1.87e-0312069611EFO_0003761
Diseasediet measurement

MFHAS1 APOB DNAH14 THADA UBXN2B KCNQ5 ZFHX3 CHD6 PRKDC SDK1

2.20e-0310499610EFO_0008111
Diseasemetabolite measurement

AOC1 CYP3A5 UGT3A1 CERS6 SLC22A24 WDFY4 SLCO1A2

2.38e-03560967EFO_0004725
Diseasecholelithiasis

ANO1 UBXN2B LRBA

3.00e-0388963EFO_0004799
Diseasemacular telangiectasia type 2

CD109 PPP2R5A

3.24e-0326962EFO_1002009

Protein segments in the cluster

PeptideGeneStartEntry
QAALQFLTLFFLAPE

URB2

1176

Q14146
FLPFPLDTAAAVNLF

ZNF385D

36

Q9H6B1
FFLRFLESPDFQPSV

PPP2R5B

171

Q15173
FFPLEELQNIFPSLD

ARHGEF1

451

Q92888
IFSALENDPLFARSP

ACOX3

51

O15254
FPFLTPVFEALNVSL

CYP3A5

226

P20815
SFLSAIDNVFLFPLD

A4GNT

106

Q9UNA3
FFLRFLESPDFQPNI

PPP2R5D

216

Q14738
FLRFLESPDFQPNIA

PPP2R5C

141

Q13362
FDPFLNFEPFLSSRP

AMER1

536

Q5JTC6
VTLFVASFPLAPVFA

ANO2

756

Q9NQ90
ASFPLAPVFALLNNV

ANO2

761

Q9NQ90
SVGFLLRPFNFFPED

AOC1

691

P19801
AAFPLAPLLALFSNL

ANO9

556

A1A5B4
EAFFNTILPAFDPAL

APOBEC2

101

Q9Y235
DFIQEFPGSPAFAAL

NUBP2

241

Q9Y5Y2
ALAFAVLSPFFNPII

OR6K2

276

Q8NGY2
FIFLRFFAPAILSPN

RASA3

481

Q14644
FFAPAILSPNLFQLT

RASA3

486

Q14644
FVAACPLAPLFALLN

ANO7

721

Q6IWH7
APRFLPNALISVDFA

PODN

161

Q7Z5L7
ALFLTIPFAFFLPEL

MALL

21

Q13021
SSNLFEEFPAALLPL

MFHAS1

281

Q9Y4C4
TPLFGVDFLQLPRDF

GMIP

546

Q9P107
LTPLRLDFNFGAAPF

CFAP65

1166

Q6ZU64
QFVDNVFSLPVDLPF

CYP26B1

216

Q9NR63
LNIDFSLPFTDFVPA

KIAA1109

561

Q2LD37
ASALALASFQIPPFE

KCNQ5

636

Q9NR82
NLALADFSFSAILPF

FPR3

66

P25089
FSFTFSLLDLPPVNE

DYNC2I1

501

Q8WVS4
AAVSAFFSTPLNPFL

PCNX1

1491

Q96RV3
FFSTPLNPFLGSAIF

PCNX1

1496

Q96RV3
SPEPLDNILLAAFEF

NUP85

341

Q9BW27
KDPFLFNDLSFPQLL

FAM205BP

196

Q63HN1
SPVIFSDFPFIFNSL

HERC6

616

Q8IVU3
FFNFPGKSAAAIALP

LRBA

206

P50851
APLSAPAFSLVFPFL

GCN1

971

Q92616
TDFFLSLVAVPAAAP

KCNK10

6

P57789
VLLFLAVAFPFAPPA

MICB

6

Q29980
LFVASFPLAPLFALL

ANO1

741

Q5XXA6
LPPLFVNFADLFLPF

AP5B1

756

Q2VPB7
LAIFDAFITPFLNPV

OR4F15

271

Q8NGB8
VTPFLNPFIFTLRND

OR9A1P

281

Q8NGU1
ANFPVRVPFEAFLAS

MYO15B

266

Q96JP2
LTLPADIDLFPFSSF

MYO15B

466

Q96JP2
DSLIDFLNFPRFQFP

APOB

4191

P04114
ELQAFQPFFIFLNLP

CD109

741

Q6YHK3
DVFAREPFVAQFSLP

DNASE1L1

121

P49184
RPEDALFFFVNNTIP

GABARAPL1

71

Q9H0R8
ELFSLLNFLEPSQFP

CHD6

636

Q8TD26
FSILFPLFIISANEA

EI24

266

O14681
RPEDALFFFVNNTIP

GABARAPL3

71

Q9BY60
TFPQAEDLYLAFPLA

CERS6

31

Q6ZMG9
LPAFFFPQAFLAAVL

DNAH14

3326

Q0VDD8
LPSFQTFFAPALDVI

ESAM

191

Q96AP7
VIFLPNAFSADFNIP

MS4A15

206

Q8N5U1
NEFFAPASLLLPDAV

IRAK4

91

Q9NWZ3
TISPEFEPVFSLFAF

ELP2

646

Q6IA86
PSPFFSAILAAFQPA

FRY

2661

Q5TBA9
LFFFPAIFLEVSLLP

GRM1

6

Q13255
FALDILFAIANGFSP

SLC22A15

146

Q8IZD6
FEPARATAFLFIIEP

SDK1

371

Q7Z5N4
LAFLPEAFDFIARDP

NIT1

81

Q86X76
FSFSLQLPESFPSLL

EPB41L3

586

Q9Y2J2
FDFLQAIEPAFISAL

MAP3K4

1096

Q9Y6R4
AAEHIPLLFFAFPSA

RETSAT

431

Q6NUM9
LLSQFFRELPPAAEF

THADA

1881

Q6YHU6
VQDFQFFPPRLFELL

SMARCA1

786

P28370
LQDPGSFNFAPRLFI

SVIL

1991

O95425
LFPNIVLENFTAFTP

SLC22A24

31

Q8N4F4
ATFLIEIAVPPLFFA

LMF2

231

Q9BU23
VFLAAFAAALGPLSF

SLC2A8

26

Q9NY64
PLFPFSHFRQFIAAI

ARHGAP27

781

Q6ZUM4
NVLTAIPFFFLPNTL

SLCO1A2

256

P46721
PFPQLFLALYDFTAR

SRMS

51

Q9H3Y6
FPFSAVVPAALEARN

URB1

781

O60287
VTPFLNPFIFTLRND

OR9A4

281

Q8NGU2
DASQLPPAFDLFEAF

SMYD3

161

Q9H7B4
FLRFLESPDFQPSIA

PPP2R5A

166

Q15172
FPANSFVISFFPSLI

LINC01619

76

G3V211
RLDFPFDLQELPAFA

CLCN2

311

P51788
SDFAFDFARPLLPNT

UGT3A1

251

Q6NUS8
PLASQFELPGDFFNL

UBXN6

281

Q9BZV1
FILLNLTFPDNFPFS

UBE2QL1

51

A1L167
PEFAALDFILVTSFP

UBXN2B

291

Q14CS0
FLRPLVFFPEATLQS

STAG3

821

Q9UJ98
RLPLFQASAFAFLAP

SLC23A2

161

Q9UGH3
NLVAAIFSAPAFPAA

PSD2

621

Q9BQI7
SAAPFFVLFLIPVES

SLC39A7

146

Q92504
AANFFFPLVLLLGLA

TMC4

586

Q7Z404
FAAFLVTELLPPFQR

PLPP5

21

Q8NEB5
RAPEFLQTLAIAAFP

WDFY4

1816

Q6ZS81
DLLLISTNPFDFPFV

MYH13

301

Q9UKX3
ETPPFLQSDVFFLFL

SLC9A1

151

P19634
GEPPLFLAASIFFAI

XDH

1261

P47989
PFLNFSTPVVLFDAL

TAAR2

286

Q9P1P5
FENLVFDQSFLAPLV

SCLT1

46

Q96NL6
FLNLALPFFGFSEPL

UBA1

926

P22314
FPPLADRFMNAVFFL

PRKDC

2371

P78527
SFPQASFQEALRPIF

TRIML1

431

Q8N9V2
PALFLFIPFNPLAES

TXNDC11

376

Q6PKC3
QPFLRFLQQPFFLAT

UNQ6494/PRO21346

6

Q6UXR6
SDFAFDFARPLLPNT

UGT3A2

251

Q3SY77
VQDFQFFPPRLFELL

SMARCA5

771

O60264
ELALSFSRVPLFPVF

TMEM38A

11

Q9H6F2
PRPFRASNSNFFFLL

TMC7

591

Q7Z402
LLFPFYIPSAEFQLN

ZFHX3

1796

Q15911
FNAILIETPLAPFFQ

ATP6V0D2

151

Q8N8Y2