Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	DNA-binding transcription factor activity, RNA polymerase II-specific	ZSCAN29 ZNF823 SP8 SP1 SP3 SP4 ZNF594 ZNF776 ZFP90 ZNF585A ZNF555 ZNF569 ZNF268 ZNF358 ZNF596 MAZ ZSCAN26 SP6 ZNF521 SP5 SP9 ZNF561 ZNF766 ZNF275 ZNF227 ZBTB11 ZNF442 ZNF251 ZNF441 ZNF239 ZNF585B SP7	1.42e-24	1412	51	32	GO:0000981
GeneOntologyMolecularFunction	RNA polymerase II transcription regulatory region sequence-specific DNA binding	ZSCAN29 ZNF823 SP8 SP1 SP3 SP4 ZNF594 ZNF776 ZFP90 ZNF585A ZNF555 ZNF569 ZNF268 ZNF358 ZNF596 MAZ ZSCAN26 SP6 ZNF521 SP5 SP9 ZNF561 ZNF766 ZNF275 ZNF227 ZBTB11 ZNF442 ZNF251 ZNF441 ZNF239 ZNF585B SP7	3.92e-24	1459	51	32	GO:0000977
GeneOntologyMolecularFunction	RNA polymerase II cis-regulatory region sequence-specific DNA binding	ZSCAN29 SP8 SP1 SP3 SP4 ZNF594 ZNF776 ZNF585A ZNF569 ZNF268 ZNF358 MAZ ZSCAN26 SP6 ZNF521 SP5 SP9 ZNF561 ZNF766 ZNF275 ZNF227 ZBTB11 ZNF251 ZNF239 ZNF585B SP7	1.93e-18	1244	51	26	GO:0000978
GeneOntologyMolecularFunction	cis-regulatory region sequence-specific DNA binding	ZSCAN29 SP8 SP1 SP3 SP4 ZNF594 ZNF776 ZNF585A ZNF569 ZNF268 ZNF358 MAZ ZSCAN26 SP6 ZNF521 SP5 SP9 ZNF561 ZNF766 ZNF275 ZNF227 ZBTB11 ZNF251 ZNF239 ZNF585B SP7	3.28e-18	1271	51	26	GO:0000987
GeneOntologyMolecularFunction	DNA-binding transcription activator activity, RNA polymerase II-specific	SP1 ZNF594 ZNF585A ZNF268 ZNF358 ZNF521 ZNF227 ZNF585B SP7	1.07e-05	560	51	9	GO:0001228
GeneOntologyMolecularFunction	DNA-binding transcription activator activity	SP1 ZNF594 ZNF585A ZNF268 ZNF358 ZNF521 ZNF227 ZNF585B SP7	1.17e-05	566	51	9	GO:0001216
MousePheno	abnormal supraoccipital bone morphology	SP8 SP3 BMPER	3.47e-05	29	31	3	MP:0000078
MousePheno	abnormal interparietal bone morphology	SP8 SP3 BMPER	1.60e-04	48	31	3	MP:0000077
MousePheno	small supraoccipital bone	SP8 BMPER	1.70e-04	9	31	2	MP:0004444
Domain	ZINC_FINGER_C2H2_2	ZSCAN29 ZNF823 SP8 SP1 SP3 SP4 ZNF594 ZNF776 ZFP90 ZNF585A ZNF555 ZNF569 ZNF268 ZNF358 ZNF596 MAZ ZSCAN26 SP6 ZNF521 SP5 PRDM13 SP9 ZNF207 ZNF561 ZNF766 ZNF275 ZNF227 ZNF831 ZBTB11 ZNF442 ZNF251 ZNF441 ZNF239 ZNF585B SP7	7.72e-37	775	51	35	PS50157
Domain	ZINC_FINGER_C2H2_1	ZSCAN29 ZNF823 SP8 SP1 SP3 SP4 ZNF594 ZNF776 ZFP90 ZNF585A ZNF555 ZNF569 ZNF268 ZNF358 ZNF596 MAZ ZSCAN26 SP6 ZNF521 SP5 PRDM13 SP9 ZNF207 ZNF561 ZNF766 ZNF275 ZNF227 ZNF831 ZBTB11 ZNF442 ZNF251 ZNF441 ZNF239 ZNF585B SP7	8.45e-37	777	51	35	PS00028
Domain	Znf_C2H2	ZSCAN29 ZNF823 SP8 SP1 SP3 SP4 ZNF594 ZNF776 ZFP90 ZNF585A ZNF555 ZNF569 ZNF268 ZNF358 ZNF596 MAZ ZSCAN26 SP6 ZNF521 SP5 PRDM13 SP9 ZNF207 ZNF561 ZNF766 ZNF275 ZNF227 ZNF831 ZBTB11 ZNF442 ZNF251 ZNF441 ZNF239 ZNF585B SP7	2.93e-36	805	51	35	IPR007087
Domain	ZnF_C2H2	ZSCAN29 ZNF823 SP8 SP1 SP3 SP4 ZNF594 ZNF776 ZFP90 ZNF585A ZNF555 ZNF569 ZNF268 ZNF358 ZNF596 MAZ ZSCAN26 SP6 ZNF521 SP5 PRDM13 SP9 ZNF207 ZNF561 ZNF766 ZNF275 ZNF227 ZNF831 ZBTB11 ZNF442 ZNF251 ZNF441 ZNF239 ZNF585B SP7	3.33e-36	808	51	35	SM00355
Domain	-	ZSCAN29 ZNF823 SP8 SP1 SP3 SP4 ZNF594 ZNF776 ZFP90 ZNF585A ZNF555 ZNF569 ZNF268 ZNF358 ZNF596 MAZ ZSCAN26 SP6 ZNF521 SP5 PRDM13 SP9 ZNF561 ZNF766 ZNF227 ZNF831 ZBTB11 ZNF442 ZNF251 ZNF441 ZNF239 ZNF585B SP7	2.22e-35	679	51	33	3.30.160.60
Domain	zf-C2H2	ZSCAN29 ZNF823 SP8 SP1 SP3 SP4 ZNF594 ZNF776 ZFP90 ZNF585A ZNF555 ZNF569 ZNF268 ZNF358 ZNF596 MAZ ZSCAN26 SP6 ZNF521 SP5 PRDM13 SP9 ZNF561 ZNF766 ZNF275 ZNF227 ZBTB11 ZNF442 ZNF251 ZNF441 ZNF239 ZNF585B SP7	4.36e-35	693	51	33	PF00096
Domain	Znf_C2H2/integrase_DNA-bd	ZSCAN29 ZNF823 SP8 SP1 SP3 SP4 ZNF594 ZNF776 ZFP90 ZNF585A ZNF555 ZNF569 ZNF268 ZNF358 ZNF596 MAZ ZSCAN26 SP6 ZNF521 SP5 PRDM13 SP9 ZNF561 ZNF766 ZNF227 ZNF831 ZBTB11 ZNF442 ZNF251 ZNF441 ZNF239 ZNF585B SP7	4.57e-35	694	51	33	IPR013087
Domain	Znf_C2H2-like	ZSCAN29 ZNF823 SP8 SP1 SP3 SP4 ZNF594 ZNF776 ZFP90 ZNF585A ZNF555 ZNF569 ZNF268 ZNF358 ZNF596 MAZ ZSCAN26 SP6 ZNF521 SP5 PRDM13 SP9 ZNF207 ZNF561 ZNF766 ZNF227 ZNF831 ZBTB11 ZNF442 ZNF251 ZNF441 ZNF239 ZNF585B SP7	9.54e-35	796	51	34	IPR015880
Domain	Sp1_fam	SP8 SP1 SP3 SP4 SP6 SP5 SP9 SP7	7.78e-20	10	51	8	IPR030450
Domain	KRAB	ZNF823 ZNF776 ZFP90 ZNF585A ZNF555 ZNF569 ZNF268 ZNF596 ZNF561 ZNF766 ZNF275 ZNF227 ZNF442 ZNF251 ZNF441 ZNF585B	9.28e-16	358	51	16	PS50805
Domain	KRAB	ZNF823 ZNF776 ZFP90 ZNF585A ZNF555 ZNF569 ZNF268 ZNF596 ZNF561 ZNF766 ZNF275 ZNF227 ZNF442 ZNF251 ZNF441 ZNF585B	9.28e-16	358	51	16	PF01352
Domain	KRAB	ZNF823 ZNF776 ZFP90 ZNF585A ZNF555 ZNF569 ZNF268 ZNF596 ZNF561 ZNF766 ZNF275 ZNF227 ZNF442 ZNF251 ZNF441 ZNF585B	1.49e-15	369	51	16	SM00349
Domain	KRAB	ZNF823 ZNF776 ZFP90 ZNF585A ZNF555 ZNF569 ZNF268 ZNF596 ZNF561 ZNF766 ZNF275 ZNF227 ZNF442 ZNF251 ZNF441 ZNF585B	1.56e-15	370	51	16	IPR001909
Domain	zf-C2H2_6	ZNF823 ZFP90 ZNF555 ZNF569 ZNF358 ZNF521 ZNF561 ZNF766 ZNF227 ZBTB11 ZNF442 ZNF251	3.65e-11	314	51	12	PF13912
Domain	NIDO_dom	SNED1 NID2	7.27e-05	5	51	2	IPR003886
Domain	NIDO	SNED1 NID2	7.27e-05	5	51	2	PS51220
Domain	NIDO	SNED1 NID2	7.27e-05	5	51	2	SM00539
Domain	NIDO	SNED1 NID2	7.27e-05	5	51	2	PF06119
Domain	Mss4-like	MSRB3 CENPV	2.03e-04	8	51	2	IPR011057
Domain	SCAN	ZSCAN29 ZSCAN26	1.02e-02	56	51	2	SM00431
Domain	SCAN_BOX	ZSCAN29 ZSCAN26	1.10e-02	58	51	2	PS50804
Domain	SCAN	ZSCAN29 ZSCAN26	1.10e-02	58	51	2	PF02023
Domain	SCAN_dom	ZSCAN29 ZSCAN26	1.10e-02	58	51	2	IPR003309
Domain	Retrov_capsid_C	ZSCAN29 ZSCAN26	1.13e-02	59	51	2	IPR008916
Pathway	REACTOME_RNA_POLYMERASE_II_TRANSCRIPTION	SP1 ZNF776 ZFP90 ZNF585A ZNF555 ZNF569 ZNF268 ZNF596 ZNF521 ZNF561 ZNF227 ZNF442 ZNF441 ZNF585B SP7	1.36e-07	1387	33	15	M734
Pathway	WP_ESTRADIOL_REGULATION_IN_PORTOSINUSOIDAL_VASCULAR_DISEASE	SP1 SP3	5.29e-05	5	33	2	M45554
Pathway	BIOCARTA_TERC_PATHWAY	SP1 SP3	7.92e-05	6	33	2	MM1564
Pathway	BIOCARTA_TERC_PATHWAY	SP1 SP3	7.92e-05	6	33	2	M22047
Pathway	BIOCARTA_TERT_PATHWAY	SP1 SP3	1.11e-04	7	33	2	MM1541
Pathway	BIOCARTA_TERT_PATHWAY	SP1 SP3	1.47e-04	8	33	2	M22015
Pathway	REACTOME_GENERIC_TRANSCRIPTION_PATHWAY	ZNF823 SP1 ZFP90 ZNF585A ZNF569 ZNF268 ZNF442 ZNF585B	3.08e-04	768	33	8	MM14851
Pathway	REACTOME_GENE_EXPRESSION_TRANSCRIPTION	ZNF823 SP1 ZFP90 ZNF585A ZNF569 ZNF268 ZNF442 DNMT1 ZNF585B	4.20e-04	1022	33	9	MM15436
Pathway	BIOCARTA_CALCINEURIN_PATHWAY	SP1 SP3	7.94e-04	18	33	2	M3430
Pathway	BIOCARTA_CALCINEURIN_PATHWAY	SP1 SP3	7.94e-04	18	33	2	MM1385
Pathway	REACTOME_RUNX2_REGULATES_OSTEOBLAST_DIFFERENTIATION	ZNF521 SP7	1.42e-03	24	33	2	M27803
Pubmed	Mammalian SP/KLF transcription factors: bring in the family.	SP8 SP1 SP3 SP4 SP6 SP5 SP9 SP7	1.27e-17	25	51	8	15820306
Pubmed	Sp8 exhibits reciprocal induction with Fgf8 but has an opposing effect on anterior-posterior cortical area patterning.	SP8 SP6 SP5 SP9 SP7	6.95e-13	9	51	5	17509151
Pubmed	Acetylation-Mimic Mutation of TRIM28-Lys304 to Gln Attenuates the Interaction with KRAB-Zinc-Finger Proteins and Affects Gene Expression in Leukemic K562 Cells.	ZNF776 ZNF555 ZNF569 CENPV ZNF561 ZNF766 ZNF227 ZBTB11 ZNF441	5.78e-12	181	51	9	37372979
Pubmed	Nkx3.1 binds and negatively regulates the transcriptional activity of Sp-family members in prostate-derived cells.	SP1 SP3 SP4 SP5	6.14e-11	6	51	4	16201967
Pubmed	Analysis of Sp transcription factors in the postmortem brain of chronic schizophrenia: a pilot study of relationship to negative symptoms.	SP1 SP3 SP4	2.97e-09	3	51	3	23540600
Pubmed	Specificity protein (Sp) transcription factors Sp1, Sp3 and Sp4 are non-oncogene addiction genes in cancer cells.	SP1 SP3 SP4	2.97e-09	3	51	3	26967243
Pubmed	Curcumin decreases specificity protein expression in bladder cancer cells.	SP1 SP3 SP4	2.97e-09	3	51	3	18593936
Pubmed	Pharmacologic doses of ascorbic acid repress specificity protein (Sp) transcription factors and Sp-regulated genes in colon cancer cells.	SP1 SP3 SP4	2.97e-09	3	51	3	21919647
Pubmed	Molecular mechanisms of transactivation and doxorubicin-mediated repression of survivin gene in cancer cells.	SP1 SP3 DNMT1	2.97e-09	3	51	3	17124180
Pubmed	Complex phenotype of mice homozygous for a null mutation in the Sp4 transcription factor gene.	SP1 SP3 SP4	2.97e-09	3	51	3	11532028
Pubmed	Functional analyses of the transcription factor Sp4 reveal properties distinct from Sp1 and Sp3.	SP1 SP3 SP4	2.97e-09	3	51	3	7559627
Pubmed	A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract.	SP1 SP3 ZFP90 ZNF585A ZNF358 SP6 ZNF521 ZNF207 ZNF275 ZNF585B SP7	5.31e-09	709	51	11	22988430
Pubmed	Sp4 is expressed in retinal neurons, activates transcription of photoreceptor-specific genes, and synergizes with Crx.	SP1 SP3 SP4	1.19e-08	4	51	3	15781457
Pubmed	Control of Fiat (factor inhibiting ATF4-mediated transcription) expression by Sp family transcription factors in osteoblasts.	SP1 SP3 SP7	1.19e-08	4	51	3	23463631
Pubmed	Sp2 is the only glutamine-rich specificity protein with minor impact on development and differentiation in myelinating glia.	SP1 SP3 SP4	1.19e-08	4	51	3	27889927
Pubmed	Reciprocal regulation of expression of the human adenosine 5'-triphosphate binding cassette, sub-family A, transporter 2 (ABCA2) promoter by the early growth response-1 (EGR-1) and Sp-family transcription factors.	SP1 SP3 SP4	2.96e-08	5	51	3	12560508
Pubmed	Inhibition of NFkappaB and pancreatic cancer cell and tumor growth by curcumin is dependent on specificity protein down-regulation.	SP1 SP3 SP4	2.96e-08	5	51	3	20538607
Pubmed	Transcription factors of the Sp1 family: interaction with E2F and regulation of the murine thymidine kinase promoter.	SP1 SP3 SP4	2.96e-08	5	51	3	10547281
Pubmed	Activation of mouse RAG-2 promoter by Myc-associated zinc finger protein.	SP1 SP3 MAZ	5.92e-08	6	51	3	15094381
Pubmed	POZ domain transcription factor, FBI-1, represses transcription of ADH5/FDH by interacting with the zinc finger and interfering with DNA binding activity of Sp1.	SP1 SP3 SP4	1.04e-07	7	51	3	12004059
Pubmed	The transcriptional activity of osterix requires the recruitment of Sp1 to the osteocalcin proximal promoter.	SP1 SP7	2.11e-06	2	51	2	21820092
Pubmed	Sp1 increases expression of cyclooxygenase-2 in hypoxic vascular endothelium. Implications for the mechanisms of aortic aneurysm and heart failure.	SP1 SP3	2.11e-06	2	51	2	10825178
Pubmed	HPV8 activates cellular gene expression mainly through Sp1/3 binding sites.	SP1 SP3	2.11e-06	2	51	2	31299490
Pubmed	Sp1 and Sp3 regulate transcription of the cyclin-dependent kinase 5 regulatory subunit 2 (p39) promoter in neuronal cells.	SP1 SP3	2.11e-06	2	51	2	19437621
Pubmed	Iron-inhibited autophagy via transcription factor ZFP27 in Parkinson's disease.	ZNF585A ZNF585B	2.11e-06	2	51	2	37668106
Pubmed	Sp1 trans-activation of cell cycle regulated promoters is selectively repressed by Sp3.	SP1 SP3	2.11e-06	2	51	2	8845379
Pubmed	Increased SP4 and SP1 transcription factor expression in the postmortem hippocampus of chronic schizophrenia.	SP1 SP4	2.11e-06	2	51	2	25175639
Pubmed	Concentration-dependent effects of endogenous S-nitrosoglutathione on gene regulation by specificity proteins Sp3 and Sp1.	SP1 SP3	2.11e-06	2	51	2	14766015
Pubmed	Sp1/Sp3 transcription factors regulate hallmarks of megakaryocyte maturation and platelet formation and function.	SP1 SP3	2.11e-06	2	51	2	25538045
Pubmed	Transcriptional control of human CD2AP expression: the role of Sp1 and Sp3.	SP1 SP3	2.11e-06	2	51	2	21604172
Pubmed	Cloning by recognition site screening of two novel GT box binding proteins: a family of Sp1 related genes.	SP3 SP4	2.11e-06	2	51	2	1454515
Pubmed	Expression of the human endogenous retrovirus (HERV) group HML-2/HERV-K does not depend on canonical promoter elements but is regulated by transcription factors Sp1 and Sp3.	SP1 SP3	2.11e-06	2	51	2	21248046
Pubmed	Robust hematopoietic specification requires the ubiquitous Sp1 and Sp3 transcription factors.	SP1 SP3	2.11e-06	2	51	2	31164147
Pubmed	Sp1 and Sp3 activate transcription of the human dopamine transporter gene.	SP1 SP3	2.11e-06	2	51	2	15816870
Pubmed	Sp family transcription factors regulate expression of rat D2 dopamine receptor gene.	SP1 SP3	2.11e-06	2	51	2	9628590
Pubmed	Transcriptional activity and Sp 1/3 transcription factor binding to the P1 promoter sequences of the human AbetaH-J-J locus.	SP1 SP3	2.11e-06	2	51	2	17681019
Pubmed	Endothelial Sp1/Sp3 are essential to the effect of captopril on blood pressure in male mice.	SP1 SP3	2.11e-06	2	51	2	37735515
Pubmed	The nuclear abundance of transcription factors Sp1 and Sp3 depends on biotin in Jurkat cells.	SP1 SP3	2.11e-06	2	51	2	14608051
Pubmed	Reduced expression of SP1 and SP4 transcription factors in peripheral blood mononuclear cells in first-episode psychosis.	SP1 SP4	2.11e-06	2	51	2	23941741
Pubmed	Sp1 and Sp3 Are the Transcription Activators of Human ek1 Promoter in TSA-Treated Human Colon Carcinoma Cells.	SP1 SP3	2.11e-06	2	51	2	26807725
Pubmed	An Sp1/Sp3 binding polymorphism confers methylation protection.	SP1 SP3	2.11e-06	2	51	2	18725933
Pubmed	Sp1/Sp3-dependent regulation of human telomerase reverse transcriptase promoter activity by the bioactive sphingolipid ceramide.	SP1 SP3	2.11e-06	2	51	2	15951564
Pubmed	Differentiation-dependent and cell-specific regulation of the hIGFBP-1 gene in human endometrium.	SP1 SP3	2.11e-06	2	51	2	9329821
Pubmed	Transcription factors Sp1 and Sp3 regulate basal transcription of the human IRF-3 gene.	SP1 SP3	2.11e-06	2	51	2	22464952
Pubmed	Isolation of cDNA clones for 42 different Krüppel-related zinc finger proteins expressed in the human monoblast cell line U-937.	ZNF594 ZNF268 ZNF227	3.88e-06	21	51	3	7865130
Pubmed	A census of human transcription factors: function, expression and evolution.	SP1 SP3 SP4 ZNF268 MAZ SP6 SP5 SP9 SP7	6.16e-06	908	51	9	19274049
Pubmed	Sp1 and Sp3 Are important regulators of AP-2gamma gene transcription.	SP1 SP3	6.32e-06	3	51	2	12801994
Pubmed	Expression of the human melanocortin-4 receptor gene is controlled by several members of the Sp transcription factor family.	SP1 SP3	6.32e-06	3	51	2	15821099
Pubmed	Laminin reduces expression of the human alpha6 integrin subunit gene by altering the level of the transcription factors Sp1 and Sp3.	SP1 SP3	6.32e-06	3	51	2	17652716
Pubmed	Regulation of human CETP gene expression: role of SP1 and SP3 transcription factors at promoter sites -690, -629, and -37.	SP1 SP3	6.32e-06	3	51	2	12730302
Pubmed	Expression patterns of SP1 and SP3 during mouse spermatogenesis: SP1 down-regulation correlates with two successive promoter changes and translationally compromised transcripts.	SP1 SP3	6.32e-06	3	51	2	18417714
Pubmed	Activation of the RNA-dependent protein kinase PKR promoter in the absence of interferon is dependent upon Sp proteins.	SP1 SP3	6.32e-06	3	51	2	16339759
Pubmed	Sp1 and Sp3 are involved in up-regulation of human deoxyribonuclease II transcription during differentiation of HL-60 cells.	SP1 SP3	6.32e-06	3	51	2	12694199
Pubmed	Functional interplay of SP family members and nuclear factor Y is essential for transcriptional activation of the human Calreticulin gene.	SP1 SP3	6.32e-06	3	51	2	26162987
Pubmed	Transcriptional regulation of BACE1, the beta-amyloid precursor protein beta-secretase, by Sp1.	SP1 SP3	6.32e-06	3	51	2	14701757
Pubmed	Regulation of the human secretin gene is controlled by the combined effects of CpG methylation, Sp1/Sp3 ratio, and the E-box element.	SP1 SP3	6.32e-06	3	51	2	15118068
Pubmed	Mesenchymal stem cells, as glioma exosomal immunosuppressive signal multipliers, enhance MDSCs immunosuppressive activity through the miR-21/SP1/DNMT1 positive feedback loop.	SP1 DNMT1	6.32e-06	3	51	2	37481646
Pubmed	Involvement of the GC-rich sequence and specific proteins (Sp1/Sp3) in the basal transcription activity of neurogranin gene.	SP1 SP3	6.32e-06	3	51	2	16677608
Pubmed	Osterix induces Col1a1 gene expression through binding to Sp1 sites in the bone enhancer and proximal promoter regions.	SP1 SP7	6.32e-06	3	51	2	23159876
Pubmed	Bifunctional properties of peroxisome proliferator-activated receptor gamma1 in KDR gene regulation mediated via interaction with both Sp1 and Sp3.	SP1 SP3	6.32e-06	3	51	2	15111490
Pubmed	Modulation of Bone Morphogenetic Protein (BMP) 2 gene expression by Sp1 transcription factors.	SP1 SP3	6.32e-06	3	51	2	17317039
Pubmed	Sp1 and Sp3 mediate basal and serum-induced expression of human CENP-W.	SP1 SP3	6.32e-06	3	51	2	20180024
Pubmed	In vivo footprinting of the human 11beta-hydroxysteroid dehydrogenase type 2 promoter: evidence for cell-specific regulation by Sp1 and Sp3.	SP1 SP3	6.32e-06	3	51	2	11850421
Pubmed	Transcription factors sp1 and sp3 regulate expression of human extracellular superoxide dismutase in lung fibroblasts.	SP1 SP3	6.32e-06	3	51	2	18314536
Pubmed	Decreased methylation and transcription repressor Sp3 up-regulated human monoamine oxidase (MAO) B expression during Caco-2 differentiation.	SP1 SP3	6.32e-06	3	51	2	12855685
Pubmed	Murine glypican-4 gene structure and expression; Sp1 and Sp3 play a major role in glypican-4 expression in 3T3-F442A cells.	SP1 SP3	6.32e-06	3	51	2	15297147
Pubmed	Accessible chromatin structure permits factors Sp1 and Sp3 to regulate human TGFBI gene expression.	SP1 SP3	6.32e-06	3	51	2	21554857
Pubmed	Sp1 and Sp3 transcription factors mediate trichostatin A-induced and basal expression of extracellular superoxide dismutase.	SP1 SP3	6.32e-06	3	51	2	15451065
Pubmed	Molecular and functional characterization of the murine ldh2 promoter region: Sp-binding GC-box domains are the key cis-elements regulating ldh2 gene expression during spermatogenesis.	SP1 SP3	6.32e-06	3	51	2	18790003
Pubmed	Transcription of human β4-galactosyltransferase 3 is regulated by differential DNA binding of Sp1/Sp3 in SH-SY5Y human neuroblastoma and A549 human lung cancer cell lines.	SP1 SP3	6.32e-06	3	51	2	30561605
Pubmed	Myc represses the p21(WAF1/CIP1) promoter and interacts with Sp1/Sp3.	SP1 SP3	6.32e-06	3	51	2	11274368
Pubmed	Identification of regulatory elements in the human adipose most abundant gene transcript-1 ( apM-1) promoter: role of SP1/SP3 and TNF-alpha as regulatory pathways.	SP1 SP3	6.32e-06	3	51	2	12378384
Pubmed	The t-PA -7351C>T enhancer polymorphism decreases Sp1 and Sp3 protein binding affinity and transcriptional responsiveness to retinoic acid.	SP1 SP3	6.32e-06	3	51	2	15466927
Pubmed	Oxidative stress regulates vascular endothelial growth factor-A gene transcription through Sp1- and Sp3-dependent activation of two proximal GC-rich promoter elements.	SP1 SP3	6.32e-06	3	51	2	12509426
Pubmed	Angiotensin-converting enzyme inhibitor promotes angiogenesis through Sp1/Sp3-mediated inhibition of notch signaling in male mice.	SP1 SP3	6.32e-06	3	51	2	36759621
Pubmed	Sp1 and Sp3 regulate the basal transcription of receptor activator of nuclear factor kappa B ligand gene in osteoblasts and bone marrow stromal cells.	SP1 SP3	6.32e-06	3	51	2	16052479
Pubmed	Sp1/3 and NF-1 mediate basal transcription of the human P2X1 gene in megakaryoblastic MEG-01 cells.	SP1 SP3	6.32e-06	3	51	2	16529657
Pubmed	Sp1 and Sp3 transcription factors regulate the basal expression of human microsomal epoxide hydrolase (EPHX1) through interaction with the E1b far upstream promoter.	SP1 SP3	6.32e-06	3	51	2	24315822
Pubmed	Sp1 and Sp3 physically interact and co-operate with GABP for the activation of the utrophin promoter.	SP1 SP3	6.32e-06	3	51	2	11237613
Pubmed	Involvement of Sp1 and Sp3 in differential regulation of human NHE3 promoter activity by sodium butyrate and IFN-gamma/TNF-alpha.	SP1 SP3	6.32e-06	3	51	2	17540780
Pubmed	SP1 and SP3 mediate progesterone-dependent induction of the 17beta hydroxysteroid dehydrogenase type 2 gene in human endometrium.	SP1 SP3	6.32e-06	3	51	2	16807381
Pubmed	Predictive value of Sp1/Sp3/FLIP signature for prostate cancer recurrence.	SP1 SP3	6.32e-06	3	51	2	23028678
Pubmed	Sp proteins and Runx2 mediate regulation of matrix gla protein (MGP) expression by parathyroid hormone.	SP1 SP3	6.32e-06	3	51	2	19306294
Pubmed	Evidence that Sp1 positively and Sp3 negatively regulate and androgen does not directly regulate functional tumor suppressor 15-lipoxygenase 2 (15-LOX2) gene expression in normal human prostate epithelial cells.	SP1 SP3	6.32e-06	3	51	2	15247906
Pubmed	Identification of an Sp factor-dependent promoter in GCET, a gene expressed at high levels in germinal center B cells.	SP1 SP3	6.32e-06	3	51	2	15482850
Pubmed	IFN-gamma and TNF-alpha regulate human NHE3 gene expression by modulating the Sp family transcription factors in human intestinal epithelial cell line C2BBe1.	SP1 SP3	6.32e-06	3	51	2	16760259
Pubmed	Regulation of the poly(ADP-ribose) polymerase-1 gene expression by the transcription factors Sp1 and Sp3 is under the influence of cell density in primary cultured cells.	SP1 SP3	6.32e-06	3	51	2	15777284
Pubmed	Involvement of Sp1/Sp3 in the activation of the GATA-1 erythroid promoter in K562 cells.	SP1 SP3	6.32e-06	3	51	2	18195733
Pubmed	Inhibition of vascular endothelial growth factor expression in HEC1A endometrial cancer cells through interactions of estrogen receptor alpha and Sp3 proteins.	SP1 SP3	6.32e-06	3	51	2	10816575
Pubmed	The HIV-Tat protein interacts with Sp3 transcription factor and inhibits its binding to a distal site of the sod2 promoter in human pulmonary artery endothelial cells.	SP1 SP3	6.32e-06	3	51	2	31863909
Pubmed	Transcriptional regulation of the mouse gene encoding the alpha-4 subunit of the GABAA receptor.	SP3 SP4	6.32e-06	3	51	2	15265862
Pubmed	Transcriptional regulation of human FE65, a ligand of Alzheimer's disease amyloid precursor protein, by Sp1.	SP1 SP3	6.32e-06	3	51	2	20091743
Pubmed	Regulation of the varicella-zoster virus ORF3 promoter by cellular and viral factors.	SP1 SP3	6.32e-06	3	51	2	23523134
Pubmed	O-GlcNAc modification of Sp3 and Sp4 transcription factors negatively regulates their transcriptional activities.	SP3 SP4	6.32e-06	3	51	2	26431879
Pubmed	Structural and functional characterization of the mouse tescalcin promoter.	SP1 SP3	6.32e-06	3	51	2	20540995
Pubmed	Sp1 and Sp3 are involved in the full transcriptional activity of centromere protein H in human nasopharyngeal carcinoma cells.	SP1 SP3	6.32e-06	3	51	2	22682030
Pubmed	The interaction with Sp1 and reduction in the activity of histone deacetylase 1 are critical for the constitutive gene expression of IL-1 alpha in human melanoma cells.	SP1 SP3	6.32e-06	3	51	2	17906119
Pubmed	A crucial role for the ubiquitously expressed transcription factor Sp1 at early stages of hematopoietic specification.	SP1 SP3	6.32e-06	3	51	2	24850855
Pubmed	HIV-1 Tat regulates the SOD2 basal promoter by altering Sp1/Sp3 binding activity.	SP1 SP3	6.32e-06	3	51	2	15706661
Pubmed	DNMT1 and Sp1 competitively regulate the expression of BACE1 in A2E-mediated photo-oxidative damage in RPE cells.	SP1 DNMT1	6.32e-06	3	51	2	30273642
Interaction	NOTCH2 interactions	ZNF823 SP1 ZNF594 ZNF555 ZNF358 MAZ ZSCAN26 ZNF766 ZNF275 BMPER	8.84e-08	423	51	10	int:NOTCH2
Interaction	LTBP2 interactions	ZNF594 ZNF555 ZNF358 ZNF766 ZNF251	2.39e-06	85	51	5	int:LTBP2
Interaction	SP9 interactions	SP9 SP7	6.28e-06	2	51	2	int:SP9
Interaction	NKX3-1 interactions	SP1 SP3 SP4 SP5	9.00e-06	52	51	4	int:NKX3-1
Interaction	TRIM28 interactions	ZNF823 ZNF776 ZFP90 ZNF555 ZNF569 ZNF268 CENPV ZNF561 ZNF766 ZNF227 ZBTB11 ZNF441 DNMT1 ZNF585B	1.16e-05	1474	51	14	int:TRIM28
Interaction	SP3 interactions	SP1 SP3 SP4 DNMT1	6.04e-05	84	51	4	int:SP3
Cytoband	19p13.2	ZNF823 ZNF358 ZNF561 ZNF442 ZNF441 DNMT1	2.15e-07	229	51	6	19p13.2
Cytoband	Ensembl 112 genes in cytogenetic band chr19p13	ZNF823 ZNF555 ZNF358 ZNF561 ZNF442 ZNF441 DNMT1	2.76e-05	797	51	7	chr19p13
Cytoband	19q13.12	ZNF585A ZNF569 ZNF585B	7.30e-05	72	51	3	19q13.12
Cytoband	Ensembl 112 genes in cytogenetic band chr2q31	SP3 SP5 SP9	1.04e-03	178	51	3	chr2q31
Cytoband	Ensembl 112 genes in cytogenetic band chr19q13	ZNF776 ZNF585A ZNF569 ZNF766 ZNF227 ZNF585B	2.01e-03	1192	51	6	chr19q13
Cytoband	2q31.1	SP5 SP9	3.98e-03	84	51	2	2q31.1
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZSCAN29 ZNF823 SP8 SP1 SP3 SP4 ZNF594 ZNF776 ZFP90 ZNF585A ZNF555 ZNF569 ZNF268 ZNF358 ZNF596 MAZ ZSCAN26 SP6 ZNF521 SP5 SP9 ZNF207 ZNF561 ZNF766 ZNF275 ZNF227 ZBTB11 ZNF442 ZNF251 ZNF441 ZNF239 ZNF585B SP7	5.20e-37	718	45	33	28
GeneFamily	Zinc fingers C2H2-type\|Sp transcription factors	SP8 SP1 SP3 SP4 SP6 SP5 SP9 SP7	6.85e-21	9	45	8	755
Coexpression	GSE15659_NAIVE_CD4_TCELL_VS_RESTING_TREG_DN	ZSCAN29 ZNF268 ZNF596 ZSCAN26 SP6 ZNF585B	2.34e-06	198	51	6	M3542
Coexpression	GSE15659_CD45RA_NEG_CD4_TCELL_VS_RESTING_TREG_DN	ZSCAN29 ZNF268 ZNF596 ZSCAN26 SP6 ZNF585B	2.34e-06	198	51	6	M3552
Coexpression	NIKOLSKY_BREAST_CANCER_19Q13.1_AMPLICON	ZNF585A ZNF569 ZNF585B	1.04e-05	22	51	3	M8692
Coexpression	GSE2706_UNSTIM_VS_2H_LPS_DC_UP	ZSCAN29 ZNF823 ZNF555 ZNF268 ZSCAN26	4.04e-05	197	51	5	M4695
ToppCell	droplet-Fat-Bat-18m-Mesenchymal-nan\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SNED1 NID2 SP1 BMPER ACSS2	1.71e-06	175	51	5	b4f01e7782cdd107d0817ef601891fd3a382bc35
ToppCell	droplet-Fat-Bat-18m-Mesenchymal-mesenchymal_stem_cell_of_adipose\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SNED1 NID2 SP1 BMPER ACSS2	1.71e-06	175	51	5	ef6f811d8e1839f405c3b41090ddf79be57a099f
ToppCell	droplet-Fat-Bat-18m-Mesenchymal\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SNED1 NID2 SP1 BMPER ACSS2	1.71e-06	175	51	5	7f7598d46d10bff1cbea42f950bdde1aaa16e9a4
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_medulla-lymphatic_endothelial_cell_of_renal_medulla\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	MSRB3 ZNF521 SP5 ZNF831	4.28e-05	170	51	4	dcc64b73134e89ae37990d4878813b86ce91dae9
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Endothelial-lymphatic_endothelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	MSRB3 ZNF521 SP5 ZNF831	4.28e-05	170	51	4	6035c92cd39c5ac54e7ec57d94888ee19f574639
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_medulla\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	MSRB3 ZNF521 SP5 ZNF831	4.28e-05	170	51	4	c8c42eda44b61440c96b202e7f54650046eb95d3
ToppCell	PCW_05-06-Mesenchymal-Mesenchymal_myocytic-mes_immature_ASM1_(8)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	SNED1 SP6 CENPV BMPER	7.01e-05	193	51	4	e2b455387d1de7812305200a2041a0f4759a6f54
ToppCell	PCW_10-12-Mesenchymal-Mesenchymal_fibroblastic-mes_immature5_(6)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	SNED1 ZNF521 CENPV BMPER	7.29e-05	195	51	4	0e55fa5b3cbeb7baee3d4ac272a3bf80381ec937
ToppCell	Bronchus_Control_(B.)-Stromal-TX-Fibroblasts-3\|Bronchus_Control_(B.) / Sample group, Lineage and Cell type	MSRB3 NID2 ZNF521 BMPER	7.89e-05	199	51	4	07b8c33342c62afd9c63ec2d757cfa3ba65d2a98
ToppCell	Tracheal-NucSeq-Stromal\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	MSRB3 SNED1 ZNF521 BMPER	8.04e-05	200	51	4	c318d14bd6fd6f42c597eb55ac9e2f48008aeb9b
ToppCell	Tracheal-NucSeq-Stromal-Fibroblastic-Fibro_perichondrial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	MSRB3 SNED1 ZNF521 BMPER	8.04e-05	200	51	4	a4ec0e80f5422b91b85264a9bb74568dd577e285
Drug	vinylene	SP8 SP1 SP4 ZNF569 MAZ ZSCAN26 SP6 ZNF207 SP7	3.43e-09	245	51	9	CID000006326
Drug	SP 0	SP1 SP3 SP4	1.26e-06	10	51	3	CID002742752
Drug	NSC24559	SP1 SP3 SP4 MAZ DNMT1	7.85e-06	122	51	5	CID000029051
Drug	homocysteic acid	SP1 SP3	1.47e-05	3	51	2	ctd:C007956
Drug	hyperoside	SP1 SP3 SP4	2.07e-05	24	51	3	ctd:C021304
Drug	ADP-ribosylarginine	SP1 SP3 SP4	2.35e-05	25	51	3	CID000126311
Drug	Sp 1 (pharmaceutical)	MSRB3 SP8 SP1 SP3 SP4 MAZ DNMT1 SP7	2.74e-05	548	51	8	CID000099040
Drug	poly(tetramethylene adipate	SP3 SP4	4.90e-05	5	51	2	CID000032794
Disease	hypospadias	SP1 SP7	1.85e-03	39	48	2	EFO_0004209
Disease	left ventricular diastolic function measurement	SP1 SP7	3.51e-03	54	48	2	EFO_0008204
Disease	neutrophil count, eosinophil count	SP1 DNMT1 SP7	5.05e-03	213	48	3	EFO_0004833, EFO_0004842
Disease	schizophrenia (implicated_via_orthology)	SP4 ZNF521	5.51e-03	68	48	2	DOID:5419 (implicated_via_orthology)
Disease	Nonorganic psychosis	SP8 SP1	5.67e-03	69	48	2	C0349204
Disease	neutrophil count, basophil count	SP1 DNMT1 SP7	5.81e-03	224	48	3	EFO_0004833, EFO_0005090
Disease	osteoporosis	SP1 SP7	6.33e-03	73	48	2	EFO_0003882
Disease	cardiovascular disease	ZNF268 SP6 ZNF831 DNMT1	6.45e-03	457	48	4	EFO_0000319

Protein segments in the cluster

Peptide	Gene	Start	Entry
SVYCKHGHLCPIDTG	DNMT1	411	P26358
GHCGINGTTYLKCHI	ADAM21	541	Q9UKJ8
GCDKGCHTYCHRPKI	BAZ2B	1951	Q9UIF8
GHPHPVKGECLYCFV	ACSS2	601	Q9NR19
HKHYGPRLKCCCGKA	CDHR5	691	Q9HBB8
GAVHKPYNCSHCGKS	MAZ	331	P56270
HCQSKFYGNGKHCLP	NID2	511	Q14112
APHLKGKLCGLCGNY	BMPER	486	Q8N8U9
EYQGLVKHTGGCHCG	CENPV	141	Q7Z7K6
AGKPKTGHLCLYCGK	PRDM13	566	Q9H4Q3
HLTGGGYAKICKPLH	PAFAH1B2	196	P68402
PGKKKQHICHIEGCG	SP4	641	Q02446
QHICHIEGCGKVYGK	SP4	646	Q02446
HVCHVPGCGKVYGKT	SP5	296	Q6BEB4
KHLHNCHIPGCGKAY	SP6	251	Q3SY56
CHIPGCGKAYAKTSH	SP6	256	Q3SY56
THHKDPGIYKCVVCG	MSRB3	76	Q8IXL7
HICHIQGCGKVYGKT	SP1	626	P08047
RTGHKCVLHFKPCGL	OSBPL2	261	Q9H1P3
LHSCHIPGCGKVYGK	SP9	331	P0CG40
HSCHIPGCGKVYGKT	SP8	356	Q8IXZ3
VRAGCKKCGYPGHLT	SREK1IP1	11	Q8N9Q2
GPCHNGGTCFHYIGK	SNED1	626	Q8TER0
QIHTGIKPHKCTYCG	ZNF561	301	Q8N587
HHGDGPYKCKLCGKA	ZNF823	186	P16415
LKHTGVKPHACQVCG	ZBTB11	671	O95625
VHTGDGPHKCKICGK	ZNF441	301	Q8N8Z8
RLHTGEKPYQCKHCG	ZNF555	556	Q8NEP9
IHTGEKPHGCHLCGK	ZNF596	216	Q8TC21
IVHKGVHTGVKPYGC	ZNF268	656	Q14587
KPIHSCHIPGCGKVY	SP7	291	Q8TDD2
CHIPGCGKVYGKASH	SP7	296	Q8TDD2
HICHIPGCGKVYGKT	SP3	621	Q02447
THLGPVKHYMCPICG	ZNF521	951	Q96K83
HIKCPHSKYGCTFIG	TRAF7	256	Q6Q0C0
IHTGEKPYKCGHCGK	ZNF585B	431	Q52M93
IHTGEKPHKCGHCGK	ZNF585A	431	Q6P3V2
GHVPYCDLCKGLSGH	ZFYVE1	66	Q9HBF4
IHTGEKPYLCIHCGK	ZSCAN26	331	Q16670
KCHICHKKLYTGPGL	ZNF207	36	O43670
IRHTGDGPHKCKICG	ZNF442	341	Q9H7R0
HTGQKPCHCSVYGKA	ZNF251	616	Q9BRH9
HTGEKPYHCIECGKA	ZNF569	656	Q5MCW4
HTGEKPYKCGVCGKG	ZNF227	626	Q86WZ6
IHTGKKPYICHECGK	ZNF594	176	Q96JF6
RIHTGEKPYKCHVCG	ZNF766	431	Q5HY98
GKVRNAGKYLCPHCG	ZNF831	136	Q5JPB2
VHTGEKPYHCGKCGK	ZNF239	396	Q16600
THTGEKPYGCHDCGK	ZSCAN29	811	Q8IWY8
HPGAHVGVGKNKCLY	MRPL27	76	Q9P0M9
IHSGAKPYGCPHCGK	ZNF275	286	Q9NSD4
GIYPGKKHHECTDCG	ZFP90	246	Q8TF47
HCPVCGKAFGHGSLL	ZNF358	236	Q9NW07
KHGIPLQGGKTHYIC	ZNF776	196	Q68DI1