Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionkinase activity

HIPK3 ANKK1 STK10 TK2 BCKDK PRKAB1 PRKAB2 CCND1 MAP2K6 TAF1L AK8 MAP3K3

1.44e-047648912GO:0016301
GeneOntologyMolecularFunctionprotein serine/threonine kinase activity

HIPK3 ANKK1 STK10 BCKDK PRKAB1 PRKAB2 MAP2K6 TAF1L MAP3K3

1.67e-04446899GO:0004674
GeneOntologyMolecularFunctionprotein kinase activity

HIPK3 ANKK1 STK10 BCKDK PRKAB1 PRKAB2 CCND1 MAP2K6 TAF1L MAP3K3

3.36e-046008910GO:0004672
GeneOntologyCellularComponentpostsynaptic specialization membrane

NLGN4X NLGN4Y ADGRB3 LRP1 GRID1 LRRC4B GRIN2A LRRTM1

2.31e-06201898GO:0099634
GeneOntologyCellularComponentpostsynaptic density membrane

NLGN4X NLGN4Y ADGRB3 LRP1 GRID1 LRRC4B GRIN2A

4.85e-06157897GO:0098839
GeneOntologyCellularComponentpostsynaptic membrane

NLGN4X NLGN4Y ADGRB3 LRP1 GRID1 LRRC4B NBEA GRIN2A LRRTM1

5.70e-05405899GO:0045211
GeneOntologyCellularComponentexcitatory synapse

NLGN4X NLGN4Y ADGRB3 GRIN2A LRRTM1

9.44e-05107895GO:0060076
GeneOntologyCellularComponentsymmetric, GABA-ergic, inhibitory synapse

NLGN4X NLGN4Y

1.07e-044892GO:0098983
GeneOntologyCellularComponentasymmetric, glutamatergic, excitatory synapse

NLGN4X NLGN4Y ADGRB3

1.42e-0424893GO:0098985
GeneOntologyCellularComponentpostsynaptic specialization

ARHGAP32 NLGN4X NLGN4Y ADGRB3 LRP1 GRID1 LRRC4B GRIN2A LRRTM1

2.91e-04503899GO:0099572
GeneOntologyCellularComponentneuron to neuron synapse

ARHGAP32 NLGN4X NLGN4Y ADGRB3 LRP1 GRID1 LRRC4B GRIN2A SLC30A3

3.86e-04523899GO:0098984
GeneOntologyCellularComponentpostsynaptic density

ARHGAP32 NLGN4X NLGN4Y ADGRB3 LRP1 GRID1 LRRC4B GRIN2A

6.77e-04451898GO:0014069
GeneOntologyCellularComponentsynaptic membrane

NLGN4X NLGN4Y ADGRB3 LRP1 GRID1 LRRC4B NBEA GRIN2A LRRTM1

8.41e-04583899GO:0097060
GeneOntologyCellularComponentnucleotide-activated protein kinase complex

PRKAB1 PRKAB2

9.62e-0411892GO:0031588
GeneOntologyCellularComponentinsulin-responsive compartment

LRP1 DENND4C

9.62e-0411892GO:0032593
GeneOntologyCellularComponentasymmetric synapse

ARHGAP32 NLGN4X NLGN4Y ADGRB3 LRP1 GRID1 LRRC4B GRIN2A

9.73e-04477898GO:0032279
GeneOntologyCellularComponentsymmetric synapse

NLGN4X NLGN4Y

1.36e-0313892GO:0032280
GeneOntologyCellularComponentglutamatergic synapse

NLGN4X NLGN4Y ADGRB3 LRP1 GRID1 LRRC4B NBEA GRIN2A LRRTM1 SLC30A3

2.46e-038178910GO:0098978
GeneOntologyCellularComponentcanonical inflammasome complex

NAIP NLRP6

2.62e-0318892GO:0061702
DomainARM-type_fold

USP24 DAAM2 NBEA HEATR5A BTAF1 USP35 IPO4 USP9Y LYST ARMC1 AGTPBP1 XPOT

7.15e-083398912IPR016024
DomainARM-like

DAAM2 NBEA HEATR5A BTAF1 USP35 IPO4 USP9Y ARMC1 AGTPBP1 XPOT

6.29e-072708910IPR011989
DomainNLGN4

NLGN4X NLGN4Y

2.25e-052892IPR030025
DomainAMPK1_CBM

PRKAB1 PRKAB2

2.25e-052892IPR032640
DomainAMPKBI

PRKAB1 PRKAB2

2.25e-052892PF04739
DomainAMPKBI

PRKAB1 PRKAB2

2.25e-052892SM01010
DomainASC_dom

PRKAB1 PRKAB2

2.25e-052892IPR006828
DomainAMPK1_CBM

PRKAB1 PRKAB2

2.25e-052892PF16561
Domain-

DAAM2 HEATR5A BTAF1 IPO4 ARMC1 AGTPBP1 XPOT

9.20e-052228971.25.10.10
DomainNlgn

NLGN4X NLGN4Y

2.22e-045892IPR000460
DomainPH_BEACH

NBEA LYST

3.33e-046892PF14844
DomainPH-BEACH_dom

NBEA LYST

6.17e-048892IPR023362
Domain-

NBEA LYST

6.17e-0488922.30.29.40
DomainPH_BEACH

NBEA LYST

6.17e-048892PS51783
DomainBEACH_dom

NBEA LYST

7.91e-049892IPR000409
DomainBEACH

NBEA LYST

7.91e-049892PS50197
DomainBeach

NBEA LYST

7.91e-049892PF02138
Domain-

NBEA LYST

7.91e-0498921.10.1540.10
DomainPapD-like

HYDIN CFAP65

7.91e-049892IPR008962
DomainBeach

NBEA LYST

7.91e-049892SM01026
DomainCation_efflux

SLC30A3 SLC30A6

9.86e-0410892IPR002524
DomainCation_efflux

SLC30A3 SLC30A6

9.86e-0410892PF01545
Domain-

SLC30A3 SLC30A6

1.20e-03118921.20.1510.10
DomainCation_efflux_TMD

SLC30A3 SLC30A6

1.20e-0311892IPR027469
DomainCarboxylesterase_B_CS

NLGN4X NLGN4Y

1.69e-0313892IPR019819
DomainCARBOXYLESTERASE_B_2

NLGN4X NLGN4Y

1.97e-0314892PS00941
DomainCOesterase

NLGN4X NLGN4Y

1.97e-0314892PF00135
DomainCarbesteraseB

NLGN4X NLGN4Y

1.97e-0314892IPR002018
DomainIBN_N

IPO4 XPOT

2.26e-0315892PF03810
DomainP-loop_NTPase

DNAH10 TK2 MTHFD1L NAIP RNF213 ABCF2 CHD3 BTAF1 HYDIN AK8 NLRP6

2.28e-038488911IPR027417
DomainIBN_N

IPO4 XPOT

2.58e-0316892SM00913
Domain-

DNAH10 TK2 MTHFD1L NAIP RNF213 ABCF2 CHD3 BTAF1 HYDIN AK8

2.87e-0374689103.40.50.300
DomainImportin-beta_N

IPO4 XPOT

2.91e-0317892IPR001494
DomainIontro_rcpt

GRID1 GRIN2A

3.27e-0318892IPR001320
DomainLig_chan-Glu_bd

GRID1 GRIN2A

3.27e-0318892PF10613
DomainIono_rcpt_met

GRID1 GRIN2A

3.27e-0318892IPR001508
DomainGlu/Gly-bd

GRID1 GRIN2A

3.27e-0318892IPR019594
DomainLig_chan-Glu_bd

GRID1 GRIN2A

3.27e-0318892SM00918
DomainLig_chan

GRID1 GRIN2A

3.27e-0318892PF00060
DomainPBPe

GRID1 GRIN2A

3.27e-0318892SM00079
DomainUSP_CS

USP24 USP35 USP9Y

3.85e-0366893IPR018200
DomainDAG/PE-bd

RASGRP3 CHN2

4.45e-0321892IPR020454
DomainHEAT_REPEAT

HEATR5A BTAF1 IPO4

4.55e-0370893PS50077
DomainUSP_1

USP24 USP35 USP9Y

4.55e-0370893PS00972
DomainUCH

USP24 USP35 USP9Y

4.73e-0371893PF00443
DomainUSP_2

USP24 USP35 USP9Y

4.73e-0371893PS00973
DomainUSP_3

USP24 USP35 USP9Y

4.92e-0372893PS50235
DomainUSP_dom

USP24 USP35 USP9Y

4.92e-0372893IPR028889
DomainPeptidase_C19_UCH

USP24 USP35 USP9Y

4.92e-0372893IPR001394
DomainAAA+_ATPase

DNAH10 NAIP RNF213 ABCF2

4.99e-03144894IPR003593
DomainAAA

DNAH10 NAIP RNF213 ABCF2

4.99e-03144894SM00382
DomainNACHT

NAIP NLRP6

5.32e-0323892PS50837
DomainNACHT_NTPase

NAIP NLRP6

5.32e-0323892IPR007111
DomainTGFb_propeptide

BMP5 INHBA

7.83e-0328892PF00688
DomainTGF-b_N

BMP5 INHBA

7.83e-0328892IPR001111
PathwayREACTOME_PROTEIN_PROTEIN_INTERACTIONS_AT_SYNAPSES

NLGN4X NLGN4Y LRRC4B GRIN2A LRRTM1

1.28e-0567645MM15327
PathwayREACTOME_PROTEIN_PROTEIN_INTERACTIONS_AT_SYNAPSES

NLGN4X NLGN4Y LRRC4B GRIN2A LRRTM1

4.56e-0587645M27617
PathwayREACTOME_NEUREXINS_AND_NEUROLIGINS

NLGN4X NLGN4Y GRIN2A LRRTM1

1.19e-0456644M27616
Pubmed

Interaction of TAGLN and USP1 promotes ZEB1 ubiquitination degradation in UV-induced skin photoaging.

USP24 USP35 USP9Y

1.35e-06989337149635
Pubmed

Genome-wide meta-analysis identifies new susceptibility loci for migraine.

STK10 INHBA LRP1 TRPM8 NBEA

1.78e-067889523793025
Pubmed

AMPK-Regulated Astrocytic Lactate Shuttle Plays a Non-Cell-Autonomous Role in Neuronal Survival.

PRKAB1 PRKAB2

6.48e-06289232877674
Pubmed

AMPK deficiency in cardiac muscle results in dilated cardiomyopathy in the absence of changes in energy metabolism.

PRKAB1 PRKAB2

6.48e-06289226023060
Pubmed

Upregulation of NF-κB by USP24 aggravates ferroptosis in diabetic cardiomyopathy.

NFKB1 USP24

6.48e-06289238056575
Pubmed

Interleukin-33 / Cyclin D1 imbalance in severe liver steatosis predicts susceptibility to ischemia reperfusion injury.

CCND1 IL33

6.48e-06289231034519
Pubmed

NF-kappaB activation by the chemopreventive dithiolethione oltipraz is exerted through stimulation of MEKK3 signaling.

NFKB1 MAP3K3

6.48e-06289215047705
Pubmed

Cyclin D1 enhances the response to estrogen and progesterone by regulating progesterone receptor expression.

CCND1 PGR

6.48e-06289220404095
Pubmed

Development of an autism severity score for mice using Nlgn4 null mutants as a construct-valid model of heritable monogenic autism.

NLGN4X NLGN4Y

6.48e-06289223183221
Pubmed

Juvenile manifestation of ultrasound communication deficits in the neuroligin-4 null mutant mouse model of autism.

NLGN4X NLGN4Y

6.48e-06289224855039
Pubmed

Sex-specific microglia state in the Neuroligin-4 knock-out mouse model of autism spectrum disorder.

NLGN4X NLGN4Y

6.48e-06289237001827
Pubmed

A NF-ĸB-Activin A signaling axis enhances prostate cancer metastasis.

INHBA NFKB1

6.48e-06289231740783
Pubmed

Modifiers of the jumonji mutation downregulate cyclin D1 expression and cardiac cell proliferation.

KDM5A CCND1

6.48e-06289215081428
Pubmed

AMPK activation of muscle autophagy prevents fasting-induced hypoglycemia and myopathy during aging.

PRKAB1 PRKAB2

6.48e-06289226039451
Pubmed

NF-kappaB1 can inhibit v-Abl-induced lymphoid transformation by functioning as a negative regulator of cyclin D1 expression.

NFKB1 CCND1

6.48e-06289212101248
Pubmed

Expression of the AMP-activated protein kinase beta1 and beta2 subunits in skeletal muscle.

PRKAB1 PRKAB2

6.48e-06289210544261
Pubmed

The role of AMP-activated protein kinase in the expression of the dystrophin-associated protein complex in skeletal muscle.

PRKAB1 PRKAB2

6.48e-06289229401588
Pubmed

Moyamoya disease patient mutations in the RING domain of RNF213 reduce its ubiquitin ligase activity and enhance NFκB activation and apoptosis in an AAA+ domain-dependent manner.

NFKB1 RNF213

6.48e-06289232139119
Pubmed

AMPKβ1 and AMPKβ2 define an isoform-specific gene signature in human pluripotent stem cells, differentially mediating cardiac lineage specification.

PRKAB1 PRKAB2

6.48e-06289233454005
Pubmed

Immunostaining Study on the Expression of NF-κB, ER, and PR in Ovarian Serous Carcinoma.

NFKB1 PGR

6.48e-06289227171541
Pubmed

Germline deletion of AMP-activated protein kinase beta subunits reduces bone mass without altering osteoclast differentiation or function.

PRKAB1 PRKAB2

6.48e-06289219723702
Pubmed

Progesterone, in addition to estrogen, induces cyclin D1 expression in the murine mammary epithelial cell, in vivo.

CCND1 PGR

6.48e-0628929275084
Pubmed

Unusually rapid evolution of Neuroligin-4 in mice.

NLGN4X NLGN4Y

6.48e-06289218434543
Pubmed

Increased cyclin E expression may obviate the role of cyclin D1 during brain development in cyclin D1 knockout mice.

CCND1 GRIN2A

6.48e-06289215715677
Pubmed

Increased progesterone receptor A expression in labouring human myometrium is associated with decreased promoter occupancy by the histone demethylase JARID1A.

KDM5A PGR

6.48e-06289224442343
Pubmed

Zinc transporters ZnT3 and ZnT6 are downregulated in the spinal cords of patients with sporadic amyotrophic lateral sclerosis.

SLC30A3 SLC30A6

6.48e-06289225284286
Pubmed

Increased Network Inhibition in the Dentate Gyrus of Adult Neuroligin-4 Knock-Out Mice.

NLGN4X NLGN4Y

6.48e-06289237080762
Pubmed

Cyclin D1 is a NF-κB corepressor.

NFKB1 CCND1

6.48e-06289222306268
Pubmed

Autism Related Neuroligin-4 Knockout Impairs Intracortical Processing but not Sensory Inputs in Mouse Barrel Cortex.

NLGN4X NLGN4Y

6.48e-06289229106499
Pubmed

Blocking AMPK β1 myristoylation enhances AMPK activity and protects mice from high-fat diet-induced obesity and hepatic steatosis.

PRKAB1 PRKAB2

6.48e-06289236543129
Pubmed

Perturbed Hippocampal Synaptic Inhibition and γ-Oscillations in a Neuroligin-4 Knockout Mouse Model of Autism.

NLGN4X NLGN4Y

6.48e-06289226456829
Pubmed

Nlgn4 knockout induces network hypo-excitability in juvenile mouse somatosensory cortex in vitro.

NLGN4X NLGN4Y

6.48e-06289224104404
Pubmed

Activation of interleukin 33-NFκB axis in granulosa cells during atresia and its role in disposal of atretic follicles†.

NFKB1 IL33

6.48e-06289238271626
Pubmed

A Cluster of Autism-Associated Variants on X-Linked NLGN4X Functionally Resemble NLGN4Y.

NLGN4X NLGN4Y

6.48e-06289232243781
Pubmed

Zinc dynamics and action at excitatory synapses.

GRIN2A SLC30A3

6.48e-06289224908489
Pubmed

Absence of deficits in social behaviors and ultrasonic vocalizations in later generations of mice lacking neuroligin4.

NLGN4X NLGN4Y

6.48e-06289222989184
Pubmed

Muscle-specific AMPK β1β2-null mice display a myopathy due to loss of capillary density in nonpostural muscles.

PRKAB1 PRKAB2

6.48e-06289224522207
Pubmed

AMP-activated protein kinase (AMPK) beta1beta2 muscle null mice reveal an essential role for AMPK in maintaining mitochondrial content and glucose uptake during exercise.

PRKAB1 PRKAB2

6.48e-06289221896769
Pubmed

Progesterone receptor-cyclin D1 complexes induce cell cycle-dependent transcriptional programs in breast cancer cells.

CCND1 PGR

6.48e-06289224606123
Pubmed

Identification of a novel AMP-activated protein kinase beta subunit isoform that is highly expressed in skeletal muscle.

PRKAB1 PRKAB2

6.48e-0628929575201
Pubmed

Recruitment of the Mammalian Histone-modifying EMSY Complex to Target Genes Is Regulated by ZNF131.

TNRC18 KDM5A AGR2 ABCF2 DPM1

9.70e-0611089526841866
Pubmed

HIV tat and neurotoxicity.

NFKB1 LRP1 GRIN2A

1.52e-051989316697675
Pubmed

Progesterone receptor B recruits a repressor complex to a half-PRE site of the estrogen receptor alpha gene promoter.

NCOR1 PGR

1.94e-05389219147702
Pubmed

Estrogen maintains myometrial tumors in a lymphangioleiomyomatosis model.

GPNMB PGR

1.94e-05389226880751
Pubmed

Immunoreactivity of progesterone receptor isoform B, nuclear factor kappaB, and IkappaBalpha in adenomyosis.

NFKB1 PGR

1.94e-05389219296948
Pubmed

Nerve Growth factor regulation of cyclin D1 in PC12 cells through a p21RAS extracellular signal-regulated kinase pathway requires cooperative interactions between Sp1 and nuclear factor-kappaB.

NFKB1 CCND1

1.94e-05389218367547
Pubmed

NF-kappa B-dependent induction of cyclin D1 by retinoblastoma protein (pRB) family proteins and tumor-derived pRB mutants.

NFKB1 CCND1

1.94e-05389212594215
Pubmed

The Relationship between MACC1/c-Met/Cyclin D1 Axis Expression and Prognosis in ESCC.

MACC1 CCND1

1.94e-05389235242498
Pubmed

Genetics of migraine in the age of genome-wide association studies.

LRP1 TRPM8

1.94e-05389222072275
Pubmed

Two distinct mechanisms underlie progesterone-induced proliferation in the mammary gland.

CCND1 PGR

1.94e-05389220133621
Pubmed

Progesterone receptor-NFκB complex formation is required for progesterone-induced NFκB nuclear translocation and binding onto the p53 promoter.

NFKB1 PGR

1.94e-05389225353185
Pubmed

Estrogens and progesterone promote persistent CCND1 gene activation during G1 by inducing transcriptional derepression via c-Jun/c-Fos/estrogen receptor (progesterone receptor) complex assembly to a distal regulatory element and recruitment of cyclin D1 to its own gene promoter.

CCND1 PGR

1.94e-05389215282324
Pubmed

BMP7 Induces Uterine Receptivity and Blastocyst Attachment.

BMP5 PGR

1.94e-05389228324064
Pubmed

Evolution of the Autism-Associated Neuroligin-4 Gene Reveals Broad Erosion of Pseudoautosomal Regions in Rodents.

NLGN4X NLGN4Y

1.94e-05389232011705
Pubmed

Induction of IκBζ Augments Cytokine and Chemokine Production by IL-33 in Mast Cells.

NFKB1 IL33

1.94e-05389232144162
Pubmed

Lack of Adipocyte AMPK Exacerbates Insulin Resistance and Hepatic Steatosis through Brown and Beige Adipose Tissue Function.

PRKAB1 PRKAB2

1.94e-05389227411013
Pubmed

Deciphering the Role of the rs2651899, rs10166942, and rs11172113 Polymorphisms in Migraine: A Meta-Analysis.

LRP1 TRPM8

1.94e-05389235454329
Pubmed

CDCA3 promotes cell proliferation by activating the NF-κB/cyclin D1 signaling pathway in colorectal cancer.

NFKB1 CCND1

1.94e-05389229627567
Pubmed

hKSR-2 inhibits MEKK3-activated MAP kinase and NF-kappaB pathways in inflammation.

NFKB1 MAP3K3

1.94e-05389216039990
Pubmed

Intracellular NF-HEV/IL-33 harbors essential roles in Ras-induced cellular transformation by contributing to cyclin D1 protein synthesis.

CCND1 IL33

1.94e-05389227155324
Pubmed

Analysis of the neuroligin 4Y gene in patients with autism.

NLGN4X NLGN4Y

1.94e-05389218628683
Pubmed

NFκB-mediated cyclin D1 expression by microRNA-21 influences renal cancer cell proliferation.

NFKB1 CCND1

1.94e-05389223981302
Pubmed

Olive oil oleuropein has anti-breast cancer properties with higher efficiency on ER-negative cells.

NFKB1 CCND1

1.94e-05389223261678
Pubmed

Metformin Prevents Nigrostriatal Dopamine Degeneration Independent of AMPK Activation in Dopamine Neurons.

PRKAB1 PRKAB2

1.94e-05389227467571
Pubmed

Daintain/AIF-1 promotes breast cancer proliferation via activation of the NF-kappaB/cyclin D1 pathway and facilitates tumor growth.

NFKB1 CCND1

1.94e-05389218341653
Pubmed

Neuroligin-4 is localized to glycinergic postsynapses and regulates inhibition in the retina.

NLGN4X NLGN4Y

1.94e-05389221282647
Pubmed

Genome-wide association study reveals three susceptibility loci for common migraine in the general population.

LRP1 TRPM8

1.94e-05389221666692
Pubmed

Haplotype structures and large-scale association testing of the 5' AMP-activated protein kinase genes PRKAA2, PRKAB1, and PRKAB2 [corrected] with type 2 diabetes.

PRKAB1 PRKAB2

1.94e-05389216505254
Pubmed

Adenoma growth stimulation by the trans-10, cis-12 isomer of conjugated linoleic acid (CLA) is associated with changes in mucosal NF-kappaB and cyclin D1 protein levels in the Min mouse.

NFKB1 CCND1

1.94e-05389212771343
Pubmed

Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity.

HIPK3 STK10 PRKAB1 PRKAB2 MAP2K6 TAF1L LYST MAP3K3 CABLES1 EIF3CL SLC30A6

2.11e-05910891136736316
Pubmed

The sequence of the human genome.

TNRC18 USF3 DNAH10 SZT2 USP24 SCNN1B RNF213 HEATR5A CFAP46

2.47e-0560389911181995
Pubmed

RUFY1 binds Arl8b and mediates endosome-to-TGN CI-M6PR retrieval for cargo sorting to lysosomes.

NCOR1 SF3B3 USP24 RNF213 IPO4 DPM1 XPOT

3.00e-0534489736282215
Pubmed

Non-catalytic beta- and gamma-subunit isoforms of the 5'-AMP-activated protein kinase.

PRKAB1 PRKAB2

3.87e-0548928621499
Pubmed

AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus.

PRKAB1 PRKAB2

3.87e-05489215058305
Pubmed

Rac1 and AMPK Account for the Majority of Muscle Glucose Uptake Stimulated by Ex Vivo Contraction but Not In Vivo Exercise.

PRKAB1 PRKAB2

3.87e-05489228389470
Pubmed

Single phosphorylation sites in Acc1 and Acc2 regulate lipid homeostasis and the insulin-sensitizing effects of metformin.

PRKAB1 PRKAB2

3.87e-05489224185692
Pubmed

Controlling skeletal muscle CPT-I malonyl-CoA sensitivity: the importance of AMPK-independent regulation of intermediate filaments during exercise.

PRKAB1 PRKAB2

3.87e-05489227941154
Pubmed

Neurobeachin: A protein kinase A-anchoring, beige/Chediak-higashi protein homolog implicated in neuronal membrane traffic.

NBEA LYST

3.87e-05489211102458
Pubmed

Nuclear factor-κB binding motifs specify Toll-like receptor-induced gene repression through an inducible repressosome.

NCOR1 NFKB1

3.87e-05489222891325
Pubmed

Dynamic zinc pools in mouse choroid plexus.

SLC30A3 SLC30A6

3.87e-05489215257151
Pubmed

H3K4me3 Demethylase Kdm5a Is Required for NK Cell Activation by Associating with p50 to Suppress SOCS1.

KDM5A NFKB1

3.87e-05489227050510
Pubmed

IL-33 markedly activates murine eosinophils by an NF-κB-dependent mechanism differentially dependent upon an IL-4-driven autoinflammatory loop.

NFKB1 IL33

3.87e-05489224043894
Pubmed

Functional modulation of AMP-activated protein kinase by cereblon.

PRKAB1 CRBN

3.87e-05489221232561
Pubmed

Mutations of the X-linked genes encoding neuroligins NLGN3 and NLGN4 are associated with autism.

NLGN4X NLGN4Y

3.87e-05489212669065
Pubmed

Homodimerization and isoform-specific heterodimerization of neuroligins.

NLGN4X NLGN4Y

3.87e-05489222671294
Pubmed

Regulation of AMPK Activity by CRBN Is Independent of the Thalidomide-CRL4CRBN Protein Degradation Axis.

PRKAB1 CRBN

3.87e-05489234073624
Pubmed

Ultrasonic vocalizations in mouse models for speech and socio-cognitive disorders: insights into the evolution of vocal communication.

NLGN4X NLGN4Y

3.87e-05489220579107
Pubmed

A revised model for AMP-activated protein kinase structure: The alpha-subunit binds to both the beta- and gamma-subunits although there is no direct binding between the beta- and gamma-subunits.

PRKAB1 PRKAB2

3.87e-05489217012231
Pubmed

AMP kinase promotes glioblastoma bioenergetics and tumour growth.

PRKAB1 PRKAB2

3.87e-05489229915361
Pubmed

The laforin-malin complex, involved in Lafora disease, promotes the incorporation of K63-linked ubiquitin chains into AMP-activated protein kinase beta subunits.

PRKAB1 PRKAB2

3.87e-05489220534808
Pubmed

Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column.

RNF213 EIF3CL

3.87e-05489218187866
Pubmed

Analysis of four neuroligin genes as candidates for autism.

NLGN4X NLGN4Y

3.87e-05489216077734
Pubmed

MiR-34a Promotes Osteogenic Differentiation of Human Adipose-Derived Stem Cells via the RBP2/NOTCH1/CYCLIN D1 Coregulatory Network.

KDM5A CCND1

3.87e-05489227453008
Pubmed

Endothelial expression of E-selectin is induced by the platelet-specific chemokine platelet factor 4 through LRP in an NF-kappaB-dependent manner.

NFKB1 LRP1

3.87e-05489215591119
Pubmed

Neuroligins 3 and 4X interact with syntrophin-gamma2, and the interactions are affected by autism-related mutations.

NLGN4X NLGN4Y

3.87e-05489217292328
Pubmed

Protein phosphatase 2A acts as a mitogen-activated protein kinase kinase kinase 3 (MEKK3) phosphatase to inhibit lysophosphatidic acid-induced IkappaB kinase beta/nuclear factor-kappaB activation.

NFKB1 MAP3K3

3.87e-05489220448038
Pubmed

Tumor necrosis factor-α regulates interleukin-33 expression through extracellular signal-regulated kinase, p38, and nuclear factor-κB pathways in airway epithelial cells.

NFKB1 IL33

3.87e-05489227060290
Pubmed

Association of three candidate genetic variants in ACMSD/TMEM163, GPNMB and BCKDK /STX1B with sporadic Parkinson's disease in Han Chinese.

BCKDK GPNMB

3.87e-05489230880162
Pubmed

DSCAM Deficiency Leads to Premature Spine Maturation and Autism-like Behaviors.

NLGN4X NLGN4Y LRRTM1

4.04e-052689334848499
Pubmed

Loss-of-Function Variants in TBC1D32 Underlie Syndromic Hypopituitarism.

SPOUT1 DNAH10 ABCF2 DPM1

5.73e-058189432060556
GeneFamilyWD repeat domain containing|BEACH domain containing

NBEA LYST

3.23e-0495521230
GeneFamilyUbiquitin specific peptidases

USP24 USP35 USP9Y

6.59e-0456553366
GeneFamilyNLR family

NAIP NLRP6

2.61e-0325552666
CoexpressionFOURATI_BLOOD_TWINRIX_AGE_25_83YO_RESPONDERS_VS_POOR_RESPONDERS_0DY_DN

TNRC18 SZT2 TK2 USP24 KCTD20 LRP1 HEATR5A USP9Y MAP2K6 AGTPBP1 CFAP46 NCKAP1L

8.27e-067468912M40863
ToppCell5'-Parenchyma_lung-Immune_Myeloid-Myeloid_monocytic-non-classical_monocyte-Non-classical_monocytes-Non-classical_monocytes_L.1.2.2.2|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

STK10 NFKB1 NAIP CHN2 LYST AGTPBP1 NCKAP1L

1.27e-07194897dfe0ece81922bfd7c6673726d3ea2365cbdb5513
ToppCellPCW_07-8.5-Epithelial-Epithelial_ciliated-epi_ciliated_(14)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

MACC1 AGR2 ADGRV1 HYDIN CFAP46 CFAP65

1.00e-061658960c714e852f912b5749de4cb0895406673979b2e6
ToppCellPCW_07-8.5-Epithelial-Epithelial_ciliated|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

MACC1 AGR2 ADGRV1 HYDIN CFAP46 CFAP65

1.00e-0616589682530f96aaefe28a13bad0474bbad043f127a86c
ToppCellkidney_cells-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-Adaptive_/_Maladaptive_/_Repairing_Fibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

NLGN4X INHBA NLGN4Y LRP1 GRID1 LRRTM1

1.37e-061748969c916af5eebd932f67dc9117e1d26ff194a2ff2c
ToppCellkidney_cells-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

NLGN4X INHBA NLGN4Y LRP1 GRID1 LRRTM1

1.37e-06174896bc71521f44a5fe013af42b06b5d1bd2446ecf3b5
ToppCelldroplet-Fat-BAT+GAT+MAT-30m-Epithelial|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DNAH10 SLC30A3 HYDIN CFAP46 CFAP65 NLRP6

1.56e-0617889658857bb8c13e0e1c6d9f5c1258f00fff62063d68
ToppCelldroplet-Fat-BAT+GAT+MAT-30m-Epithelial-nan|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DNAH10 SLC30A3 HYDIN CFAP46 CFAP65 NLRP6

1.56e-061788968b7df6ab8709d9ab9dff97677cc4561aec2745bc
ToppCelldroplet-Fat-BAT+GAT+MAT-30m-Epithelial-epithelial_cell|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DNAH10 SLC30A3 HYDIN CFAP46 CFAP65 NLRP6

1.56e-06178896b0baf5667e3301898b3e45e974b8a8530af6a338
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

BMP5 INHBA LRP1 DAAM2 GRIN2A PGR

2.35e-0619189639092a0aff8097617820c59f5fea9ee2bb4f63a2
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast-|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

BMP5 INHBA LRP1 DAAM2 GRIN2A PGR

2.35e-06191896ee5f1b1c59029c46cbb1a00935c03b9317bb9da9
ToppCellControl-Myeloid-cMonocyte|World / Disease state, Lineage and Cell class

STK10 NAIP KCTD20 DAAM2 CHN2 AGTPBP1

2.57e-06194896f852f5258617a66a4fbd56d64c7b47272e7b8b60
ToppCellCOVID-19-Epithelial|COVID-19 / Condition, Lineage and Cell class

SELENBP1 DNAH10 AGR2 HYDIN CFAP46 CFAP65

2.81e-0619789618fd7344628a87d5c7ef5efb66e260a4136245bf
ToppCell5'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.2.1|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ARHGAP32 MACC1 AGR2 NBEA HYDIN CFAP46

2.89e-06198896d0ecace1fad24ce50b0935036fabb07e6c9e372d
ToppCellBronchus_Control_(B.)-Immune-TX-MoAM-2|Bronchus_Control_(B.) / Sample group, Lineage and Cell type

NTAN1 NAIP LRP1 DAAM2 GPNMB NCKAP1L

2.97e-06199896fb63885273d906a85fef178d859d20a311eb8a72
ToppCellremission-multiplets|World / disease stage, cell group and cell class

SELENBP1 INHBA PROX2 MED12L DAAM2

9.79e-06142895286d01b4f95e9c0b38b91958f925f3797dffd596
ToppCellremission-multiplets|remission / disease stage, cell group and cell class

SELENBP1 INHBA PROX2 MED12L DAAM2

1.24e-05149895e9974260a5f2999b363f306cae005698c912893a
ToppCellControl-Epithelial_airway-Ciliated_cells-Ciliated|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

DNAH10 HYDIN AK8 CFAP46 CFAP65

1.45e-051548954e3bc24043144143842627cacf6f90dda2228910
ToppCellControl-Epithelial_airway-Ciliated_cells|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

DNAH10 HYDIN AK8 CFAP46 CFAP65

1.45e-051548957556a4b2b062da5ae7ec2bbb66e745e7662db628
ToppCellfacs-Marrow-B-cells-24m-Lymphocytic-precursor_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ANKK1 DNAH10 TRPM8 ADGRV1 HYDIN

1.74e-05160895c381ec6be8cf887861cc18f831a20db42f953fe1
ToppCellfacs-Marrow-B-cells-24m-Lymphocytic-pre_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ANKK1 DNAH10 TRPM8 ADGRV1 HYDIN

1.74e-0516089525c8f3d2a6d14ff0ca0b965fce89d3ff22f40585
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-kidney_interstitial_fibroblast_5|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

BMP5 DAAM2 GRID1 GRIN2A PGR

2.20e-05168895d19a115365c5415e51c039718d7669de788fcf33
ToppCell3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.0.2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

DNAH10 NBEA HYDIN CFAP46 CFAP65

2.27e-0516989514aadc2d1bf66eb47dac33b4d61ddb3c942caa4f
ToppCellControl-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_2|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ARHGAP32 NLGN4Y LRP1 DAAM2 PGR

2.33e-051708955570c0e825bca77613bf0ebde620cf744fa1cb84
ToppCell5'-Parenchyma_lung-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophages-Alveolar_macrophages_L.1.6.0.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

INHBA LRP1 RNF213 GPNMB DENND4C

2.47e-05172895c8ea80042faf923b08ff03d73100533d521d73ef
ToppCellfacs-Trachea-3m-Epithelial-airway_epithelial-tracheobronchial_ciliated_cell-ciliated_cell|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

DNAH10 HYDIN AK8 CFAP46 CFAP65

2.83e-051778953cfde67b93f3986312f5e74e42504214d966e7dc
ToppCellfacs-Trachea-3m-Epithelial-airway_epithelial-tracheobronchial_ciliated_cell|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

DNAH10 HYDIN AK8 CFAP46 CFAP65

2.83e-0517789512a52a12a87a31e501ced611f46a90d172ca7e35
ToppCellfacs-Trachea-nan-3m-Epithelial-ciliated_columnar_cell_of_tracheobronchial_tree|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DNAH10 HYDIN AK8 CFAP46 CFAP65

3.07e-05180895cf6e9f757afeb342c5023f6e6152a1b4d0d164b4
ToppCellP03-Epithelial-airway_epithelial_cell-club_cell|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

AGR2 HYDIN AK8 CFAP46 CFAP65

3.15e-0518189560a91587c59029a34e7bec1255083337fe21b72a
ToppCellFetal_29-31_weeks-Epithelial-ciliated_cell-D088|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

DNAH10 HYDIN AK8 CFAP46 CFAP65

3.15e-05181895dfce05bd472f67e6e2bb60ebd6fd34f0a9aeeca6
ToppCellAdult-Epithelial-ciliated_cell-D122|Adult / Lineage, Cell type, age group and donor

DNAH10 HYDIN AK8 CFAP46 CFAP65

3.23e-051828957ded554a4b441e6496db673ba206c0d76ccad7d9
ToppCellControl-Epithelial_cells-Airway_ciliated|Control / group, cell type (main and fine annotations)

DNAH10 HYDIN AK8 CFAP46 CFAP65

3.23e-05182895fb725d10d9ed25dfc6d5bb69cfef78513f7d3e8f
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Mesenchymal-Myocytic_interstitial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

ADGRB3 DAAM2 GRID1 LRRC4B PGR

3.32e-05183895667717366cb181b8a04a347e64f0f5a4dfc6ee7f
ToppCellP07-Epithelial-airway_epithelial_cell|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

DNAH10 HYDIN AK8 CFAP46 CFAP65

3.40e-05184895a5e7af3392e9d6ddad0397f1eeb6b91ed1107cc2
ToppCellP07-Epithelial-airway_epithelial_cell-club_cell|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

DNAH10 HYDIN AK8 CFAP46 CFAP65

3.40e-05184895ab469b9e06212462cbe2e4db8775c6778db855e6
ToppCellChildren_(3_yrs)-Epithelial-ciliated_cell-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

DNAH10 HYDIN AK8 CFAP46 CFAP65

3.40e-051848955daff849625f2f41d56615569c0ed59cd733b34c
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

BMP5 ADGRB3 DAAM2 GRID1 GRIN2A

3.49e-051858957092436b4db90289516ed130ade596e3021cffaf
ToppCellControl-Myeloid-Macrophage_Alveolar|World / Disease state, Lineage and Cell class

MACC1 INHBA LRP1 GPNMB CABLES1

3.49e-0518589585cb81759589a26d83676cffbf2bc37399683c10
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte-|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

BMP5 ADGRB3 DAAM2 GRID1 GRIN2A

3.49e-05185895a8ca7819066d5297ef6966e7f3e2c9f8a7673fdc
ToppCellCOVID-19-Epithelial_cells-Airway_ciliated|COVID-19 / group, cell type (main and fine annotations)

DNAH10 HYDIN AK8 CFAP46 CFAP65

3.49e-0518589518a40f0a338aa398d81384b5159fb80ce8a2020c
ToppCellfacs-Mammary_Gland-Mammary_Gland-21m-Epithelial-luminal_epithelial_cell_of_mammary_gland|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SCNN1B HYDIN PGR CFAP46 CFAP65

3.59e-0518689502fbb02c495e7d64c4ab50e42e5197782f2c0816
ToppCell5'-Adult-Distal_Rectal-Mesenchymal-fibroblastic-Stromal_1_(CCL11+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

BMP5 NLGN4X NLGN4Y LRP1 HYDIN

3.59e-05186895f07e0c0d9c80ac9d8d679950e7d0c812becb85a3
ToppCellCOPD-Epithelial-Ciliated|COPD / Disease state, Lineage and Cell class

DNAH10 HYDIN AK8 CFAP46 CFAP65

3.68e-05187895f0fd0792f6926f705d175f6e6fd480f12c7a3bd4
ToppCellEpithelial-ciliated_cell|World / Lineage, Cell type, age group and donor

DNAH10 HYDIN AK8 CFAP46 CFAP65

3.77e-0518889561a459f3fe57e5728efc72637ff2edc2d343492b
ToppCellAdult-Epithelial-ciliated_cell-D231|Adult / Lineage, Cell type, age group and donor

DNAH10 HYDIN AK8 CFAP46 CFAP65

3.77e-0518889534b11f72ca73153d02edcd09b38983ad1a504659
ToppCell5'-Adult-LargeIntestine-Mesenchymal-fibroblastic-Stromal_2_(NPY+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

BMP5 NLGN4X DAAM2 GRID1 GRIN2A

3.77e-05188895997dcfc4f08738ab398d8abc15e4fd2fc6619862
ToppCellChildren_(3_yrs)-Epithelial-ciliated_cell|Children_(3_yrs) / Lineage, Cell type, age group and donor

DNAH10 HYDIN AK8 CFAP46 CFAP65

3.77e-051888952b6dfc88be9ded7b88da9fe78a9cd9f9b3af8af3
ToppCell3'-Parenchyma_lung-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophage_CCL3+-Alveolar_macrophage_CCL3+_L.1.0.2.4|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

MACC1 INHBA LRP1 GPNMB NCKAP1L

3.87e-05189895a59025e82fabd9d60e2438dee85b2644478cc7c8
ToppCellCOVID-19-lung-Ciliated|COVID-19 / Disease (COVID-19 only), tissue and cell type

DNAH10 HYDIN AK8 CFAP46 CFAP65

3.87e-05189895a2da5debd10f27b1280b40141ef0bfef007cc72c
ToppCellChildren_(3_yrs)-Epithelial-ciliated_cell-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

DNAH10 HYDIN AK8 CFAP46 CFAP65

3.87e-0518989568a3cf7763d6f9b95d6d6524eff7a16042703f1d
ToppCellControl-Epithelial-Ciliated|Control / Disease state, Lineage and Cell class

DNAH10 HYDIN AK8 CFAP46 CFAP65

3.87e-05189895c007fccd08728db3ea99af9da91d67b9b16dabb3
ToppCellAdult-Epithelial-ciliated_cell|Adult / Lineage, Cell type, age group and donor

DNAH10 HYDIN AK8 CFAP46 CFAP65

3.87e-05189895b679920f0993e917dd86da082113bfbd85ea1ca5
ToppCellCOVID-19-lung-Ciliated|lung / Disease (COVID-19 only), tissue and cell type

DNAH10 HYDIN AK8 CFAP46 CFAP65

3.87e-0518989527329c4661aebabd19fac7fe5dca263fe99d76f3
ToppCellCOPD-Myeloid-Macrophage_Alveolar|COPD / Disease state, Lineage and Cell class

MACC1 INHBA LRP1 GPNMB DENND4C

3.97e-05190895006e31606d637033bc81333816ee332773d36b08
ToppCell368C-Epithelial_cells|368C / Donor, Lineage, Cell class and subclass (all cells)

SELENBP1 AGR2 SCNN1B CCND1 ADGRV1

3.97e-05190895459811e88d3001816c2d89034e0921c24918c17f
ToppCellCOPD-Myeloid-Macrophage_Alveolar|Myeloid / Disease state, Lineage and Cell class

MACC1 INHBA LRP1 GPNMB DENND4C

3.97e-051908959fc763d65470ba8858b973689c4d4358faab7dd3
ToppCellPCW_13-14|World / Celltypes from embryonic and fetal-stage human lung

NCOR1 BMP5 NLGN4Y USP9Y FRMD1

3.97e-0519089562a3ec1ae0829602b0569cc051210551644f1d46
ToppCellCOVID-19-Epithelial_cells-Airway_goblet|COVID-19 / group, cell type (main and fine annotations)

MACC1 AGR2 SCNN1B NBEA ADGRV1

3.97e-0519089551ca9ef4df3220487152fcf684147730637c7cc1
ToppCellBAL-Control-Epithelial|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)

SELENBP1 DNAH10 AGR2 HYDIN CFAP65

4.07e-051918959f19098f260d5542aa8ba7eb6f91b44d0db6e0a4
ToppCellControl-Epithelial-Ciliated_cells|Control / Condition, Lineage and Cell class

SELENBP1 DNAH10 HYDIN CFAP46 CFAP65

4.07e-05191895ea1d2c6838119b7019e9a2ff71d6212262b51b57
ToppCellBAL-Control-Epithelial|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

SELENBP1 DNAH10 AGR2 HYDIN CFAP65

4.07e-051918955129f778a9283bfac4ff322c21c5ca71da4b7174
ToppCellBAL-Control-Epithelial-Epithelial|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)

SELENBP1 DNAH10 AGR2 HYDIN CFAP65

4.07e-05191895df8a1a6e78aa0cb941b94cb676bd6891d79f3687
ToppCellnucseq-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal-Ciliated|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

DNAH10 HYDIN AK8 CFAP46 CFAP65

4.07e-05191895e417bf491f8b8d7838a61f7f4f6b1740ba97aa3f
ToppCellControl-Epithelial|Control / Disease group,lineage and cell class (2021.01.30)

SELENBP1 DNAH10 AGR2 HYDIN CFAP65

4.07e-05191895b78547dae8328244a47c83346447bdd787efbcae
ToppCellnucseq-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

DNAH10 HYDIN AK8 CFAP46 CFAP65

4.07e-051918959d31c8424d35bdc0c27188b68bfd0f731af3600b
ToppCellBAL-Control-Epithelial-Epithelial|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

SELENBP1 DNAH10 AGR2 HYDIN CFAP65

4.07e-05191895c50d6a1a6209ed4157f7c00fc24d4ecb43790f44
ToppCellControl-Epithelial|Control / Condition, Lineage and Cell class

SELENBP1 DNAH10 HYDIN CFAP46 CFAP65

4.07e-051918956228302febdb3dffe37dece7062d27ac9ccc6d4b
ToppCellnucseq-Epithelial-Epithelial_Airway|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

DNAH10 HYDIN AK8 CFAP46 CFAP65

4.07e-051918951c528f72c9ef3ef3a850b05e4a9715190832270c
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

BMP5 INHBA LRP1 DAAM2 GRIN2A

4.17e-05192895d3c1ad4667a1e223a83ca0fcd5991a0b96f1199a
ToppCellCOPD-Epithelial|COPD / Disease state, Lineage and Cell class

SELENBP1 AGR2 ADGRV1 HYDIN CFAP46

4.17e-051928950644fad5df18f0021f6f49cca996d8cf47f972ff
ToppCelldroplet-Limb_Muscle-MUSCLE-30m-Mesenchymal-mesenchymal_stem_cell|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

BMP5 INHBA LRP1 GPNMB IL33

4.17e-0519289511088878043a6ff95ba1970361256a82e434b80a
ToppCell5'-GW_trimst-2-SmallIntestine-Endothelial-lymphatic_endothelial-LEC4_(STAB2+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

NTAN1 RASGRP3 SCNN1B SLC30A3 IL33

4.17e-051928955388f3115ab285f3f3001af1d71543ed64b9e044
ToppCellControl-Myeloid-cMonocyte|Control / Disease state, Lineage and Cell class

NAIP KCTD20 DAAM2 CHN2 AGTPBP1

4.17e-05192895ad04c9c4bdebf94615cee1904ca48197e62c923b
ToppCellIPF-Epithelial-Ciliated|World / Disease state, Lineage and Cell class

DNAH10 HYDIN AK8 CFAP46 CFAP65

4.17e-05192895d903bbd6c18e29e2c4cdedeb3fea1fd5ad7baa11
ToppCellCOPD-Epithelial-Ciliated|World / Disease state, Lineage and Cell class

DNAH10 HYDIN AK8 CFAP46 CFAP65

4.17e-05192895eab1105cd1a98cfcd3d74dc5c9b89e1799bba59e
ToppCellIPF-Epithelial-Ciliated|IPF / Disease state, Lineage and Cell class

DNAH10 HYDIN AK8 CFAP46 CFAP65

4.17e-05192895354adc1354bf596fbc60dd45c0169688e6f45165
ToppCellPCW_10-12-Epithelial-Epithelial_airway-epi_proximal_secretory_(0)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

MACC1 NLGN4X AGR2 SCNN1B ADGRV1

4.27e-05193895b25cdca3a1e381784ae48ca73c51cbb6ac62b811
ToppCellCTRL-Myeloid-Alveolar_Macrophage|Myeloid / Disease state, Lineage and Cell class

MACC1 LRP1 GPNMB DENND4C NCKAP1L

4.27e-0519389580871d963c23a6befe58e5e60b7f7d1a1b227ce2
ToppCellAdult-Immune-alveolar_macrophage_(MARCO_positive)-D122|Adult / Lineage, Cell type, age group and donor

STK10 LRP1 GPNMB DENND4C NCKAP1L

4.27e-05193895cc1b6d3bf56e4a88f6fe23dd036a83cf5538c958
ToppCellControl-Epithelial-Ciliated|Epithelial / Disease state, Lineage and Cell class

DNAH10 CHN2 HYDIN AK8 CFAP46

4.27e-051938950e37d454f3735edd936ee9a5f5f516ac3aad400e
ToppCellNS-moderate-d_0-4|moderate / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

DNAH10 ADGRV1 HYDIN CFAP46 CFAP65

4.27e-05193895ea345d34440b25f65358a53dc72831998d1c3620
ToppCellIPF-Epithelial-Ciliated|Epithelial / Disease state, Lineage and Cell class

DNAH10 CHN2 HYDIN AK8 CFAP46

4.27e-05193895ad58f5080e0ba65c845056ea6b79037b636e9c64
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

BMP5 LRP1 DAAM2 GRIN2A PGR

4.38e-0519489581713e0409e8be695ba5dfdc67a997b33435dd9e
ToppCellControl-Epithelial-Ciliated|World / Disease state, Lineage and Cell class

DNAH10 AGR2 HYDIN AK8 CFAP46

4.38e-05194895958e648138676d46698090b4046cb484083ae449
ToppCellCTRL-Myeloid-Alveolar_Macrophage|CTRL / Disease state, Lineage and Cell class

MACC1 LRP1 GPNMB DENND4C NCKAP1L

4.38e-05194895be69b20afa915978c4cf2feb0bb21ab7c1f301a5
ToppCellwk_15-18-Epithelial-Proximal_epithelial|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

DNAH10 AGR2 HYDIN CFAP46 CFAP65

4.38e-05194895b0477583301dc6d9767b667bd2f8f94fbfaa6f81
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Immune-Myeloid-Macrophage_Dendritic-M2_Macrophage|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

STK10 LRP1 GPNMB DENND4C NCKAP1L

4.38e-0519489545708cb2cafde10bf4e4798b81d47c3b1f6aaa14
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

BMP5 LRP1 DAAM2 GRIN2A PGR

4.38e-05194895627cffe2d448e74fc5df92e74e5b922a73304137
ToppCellPCW_10-12-Epithelial-Epithelial_airway-epi_proximal_progenitor2_(4)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

MACC1 AGR2 SCNN1B IQCJ-SCHIP1 ADGRV1

4.49e-05195895d673f8844896d5c7b76a7bc7f6b88a039f1bc263
ToppCellfacs-Brain_Myeloid-Hippocampus|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RASGRP3 PRKAB1 USP24 MED12L LRP1

4.49e-05195895a1478021a3ed0e779716393124ca2a7770c433b7
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Immune-Myeloid-Macrophage_Dendritic|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

STK10 LRP1 GPNMB DENND4C NCKAP1L

4.49e-05195895247803cf58c6d9c561a52aa34e581188ddad197e
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

INHBA LRP1 DAAM2 GRID1 GRIN2A

4.49e-05195895edd4cd8402af81737b2074f9dce71cc6ab09be7e
ToppCellControl_saline-Epithelial_airway-airway_epithelial-Ciliated|Control_saline / Treatment groups by lineage, cell group, cell type

DNAH10 AGR2 HYDIN AK8 CFAP65

4.49e-0519589560067b5359174f0d1a8b5748bfc0690762e9e740
ToppCellCTRL|World / Disease state, Lineage and Cell class

MACC1 LRP1 GPNMB DENND4C NCKAP1L

4.49e-05195895cad77cdc6e0aa0875eff5ecd3805a6cf056d729d
ToppCellBAL-Mild-Epithelial-Epithelial-Basal/Club-|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

SELENBP1 AGR2 SCNN1B CCND1 IL33

4.60e-05196895a4d05d85fbafa869df19bba3881020ea433d81fb
ToppCellChildren_(3_yrs)-Immune-monocyte|Children_(3_yrs) / Lineage, Cell type, age group and donor

STK10 NAIP AGTPBP1 MAP3K3 NCKAP1L

4.60e-05196895cacd69be72e6167814f7adea7c5fa114f3103bbb
ToppCellBAL-Mild-Epithelial-Epithelial-Basal/Club-|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

SELENBP1 AGR2 SCNN1B CCND1 IL33

4.60e-0519689591a3c3091064f1f5a3bdc1dd5883fc24dce8ff05
ToppCellBAL-Mild-Epithelial-Epithelial-Basal/Club|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

SELENBP1 AGR2 SCNN1B CCND1 IL33

4.60e-05196895e819088a74d29e958371aa851ac9c74ec55367b7
ToppCellBAL-Mild-Epithelial-Epithelial-Basal/Club|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)

SELENBP1 AGR2 SCNN1B CCND1 IL33

4.60e-05196895e675d661b6494ac3a85ba7ee5bdeaa98b8bbe957
ToppCell343B-Myeloid-Macrophage-FABP4+_Macrophage_2|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

MACC1 INHBA LRP1 RNF213 GPNMB

4.60e-051968955ed7f063fc4ba213fe15256caf77f59c9e476290
ToppCellIPF-Epithelial|IPF / Disease state, Lineage and Cell class

DNAH10 AGR2 HYDIN AK8 CFAP46

4.60e-0519689587d9881cfec461a5d89b688a83749b618c519485
DrugHaloperidol [52-86-8]; Down 200; 10.6uM; HL60; HG-U133A

NCOR1 ARHGAP32 SF3B3 NTAN1 SZT2 KDM5A TK2 ABCF2

1.18e-062008982039_DN
Diseaseautism spectrum disorder (implicated_via_orthology)

ARHGAP32 NLGN4X KDM5A NLGN4Y BCKDK NBEA

6.91e-06152896DOID:0060041 (implicated_via_orthology)
DiseaseColorectal Carcinoma

NLGN4X SELENBP1 MTHFD1L SCNN1B LRP1 GRID1 CCND1 GRIN2A GPNMB AGTPBP1 CABLES1

8.67e-067028911C0009402
DiseaseSchizophrenia

ANKK1 ARHGAP32 SELENBP1 LRP1 DAAM2 GRID1 CCND1 GRIN2A LRRTM1 SLC30A3 CFAP65

7.06e-058838911C0036341
DiseaseCommon Migraine

LRP1 TRPM8

1.87e-047892C0338480
DiseaseAbdominal Migraine

LRP1 TRPM8

3.19e-049892C0270858
DiseaseSick Headaches

LRP1 TRPM8

3.19e-049892C0700438
DiseaseAcute Confusional Migraine

LRP1 TRPM8

3.19e-049892C0521664
DiseaseStatus Migrainosus

LRP1 TRPM8

3.19e-049892C0338489
DiseaseCervical Migraine Syndrome

LRP1 TRPM8

3.19e-049892C0007852
DiseaseHemicrania migraine

LRP1 TRPM8

3.19e-049892C0018984
Diseasepancreatic adenocarcinoma (is_marker_for)

NFKB1 CCND1

3.98e-0410892DOID:4074 (is_marker_for)
DiseaseCarcinoma, Granular Cell

SELENBP1 NFKB1 CCND1 PGR

4.28e-04116894C0205644
DiseaseAdenocarcinoma, Tubular

SELENBP1 NFKB1 CCND1 PGR

4.28e-04116894C0205645
DiseaseAdenocarcinoma, Oxyphilic

SELENBP1 NFKB1 CCND1 PGR

4.28e-04116894C0205642
DiseaseCarcinoma, Cribriform

SELENBP1 NFKB1 CCND1 PGR

4.28e-04116894C0205643
DiseaseAdenocarcinoma, Basal Cell

SELENBP1 NFKB1 CCND1 PGR

4.28e-04116894C0205641
DiseaseAdenocarcinoma

SELENBP1 NFKB1 CCND1 PGR

4.28e-04116894C0001418
Diseasedevelopmental disorder of mental health (implicated_via_orthology)

NCOR1 GRIN2A NCKAP1L

4.42e-0449893DOID:0060037 (implicated_via_orthology)
DiseaseMigraine Disorders

LRP1 TRPM8

6.87e-0413892C0149931
Disease3-hydroxypropylmercapturic acid measurement

STK10 TK2 MED12L GRID1 IQCJ-SCHIP1 CHN2

6.99e-04352896EFO_0007014
Diseasemigraine disorder

STK10 INHBA LRP1 RNF213 TRPM8 NBEA

7.52e-04357896MONDO_0005277
DiseaseMalignant neoplasm of liver

NCOR1 SPATA21 CCND1 CHN2

9.14e-04142894C0345904
DiseaseLiver neoplasms

NCOR1 SPATA21 CCND1 CHN2

9.14e-04142894C0023903
Diseaseovarian carcinoma (is_implicated_in)

CCND1 MAP2K6

9.21e-0415892DOID:4001 (is_implicated_in)
DiseaseAnilide use measurement

LRP1 TRPM8

9.21e-0415892EFO_0009938
DiseaseHeadache

LRP1 RNF213 TRPM8

9.68e-0464893HP_0002315
Diseasemigraine without aura, susceptibility to, 4

LRP1 TRPM8

1.05e-0316892MONDO_0011847
Diseaselevel of Sterol ester (27:1/20:3) in blood serum

NTAN1 USP24

1.49e-0319892OBA_2045199
Diseasehydrocephalus (implicated_via_orthology)

HYDIN AK8

1.49e-0319892DOID:10908 (implicated_via_orthology)
DiseaseColorectal Neoplasms

SELENBP1 GRID1 GRIN2A GPNMB CABLES1

1.54e-03277895C0009404
DiseaseAntimigraine preparation use measurement

LRP1 TRPM8

1.82e-0321892EFO_0009939
Diseasepolycystic ovary syndrome (biomarker_via_orthology)

NCOR1 PGR

1.82e-0321892DOID:11612 (biomarker_via_orthology)
Diseasesmall cell lung carcinoma

BBX ADGRV1 IL33

1.84e-0380893EFO_0000702
Diseasewaist circumference

OVCH2 DNAH10 BCKDK IQCJ-SCHIP1 SH2B1 CABLES1

1.92e-03429896EFO_0004342
Diseasemonocyte count

BBX SZT2 NFKB1 PROX2 LYPD5 PRKAB1 MED12L ADGRV1 LYST CABLES1 NLRP6

2.06e-0313208911EFO_0005091
Diseasemigraine disorder, Headache

LRP1 RNF213 TRPM8

2.27e-0386893HP_0002315, MONDO_0005277
DiseaseLiver Failure, Acute

INHBA GPNMB

2.38e-0324892C0162557
Diseasediabetes mellitus (implicated_via_orthology)

BMP5 LRP1

2.79e-0326892DOID:9351 (implicated_via_orthology)
Diseasepancreatic ductal adenocarcinoma (is_marker_for)

AGR2 CCND1

3.01e-0327892DOID:3498 (is_marker_for)

Protein segments in the cluster

PeptideGeneStartEntry
LHSPLFPEMQSLHSA

URB2

796

Q14146
IPEEFPNFHHMEKLL

NAIP

1121

Q13075
PLMIIHHLDECPHSQ

AGR2

71

O95994
HMLFLDEPTNHLDIE

ABCF2

536

Q9UG63
HPHGIMIIEDPAALN

BBX

431

Q8WY36
HLAPQEHMQNLPFEP

ADGRB3

1366

O60242
MNFLHSIKPPLLHLD

ANKK1

131

Q8NFD2
IMFDVLIHDPSHFLN

GPNMB

261

Q14956
YELHAMPAKSDLHPI

ADGRV1

1496

Q8WXG9
LFMDHPNPPVVHSAL

ARMC1

46

Q9NVT9
RALHLLAMQADPVHP

CFAP46

1961

Q8IYW2
AHNMGNHLPLLPAES

CRBN

11

Q96SW2
PEPNHVMLNHLYALS

PRKAB2

231

O43741
TPHDFIEHFLSKMPE

CCND1

156

P24385
QDPRISPLFGHLDMH

BCKDK

341

O14874
IPMEEFNLHLTGDIH

MTHFD1L

476

Q6UB35
PPHEDLMVQIHSILA

AGTPBP1

126

Q9UPW5
IMDADLSHHPKFIPE

DPM1

116

O60762
PFLMLQARQSEDHPH

INHBA

291

P08476
KHFPDILNMPSELQH

DAAM2

851

Q86T65
LAHHIQLIFDLMEPA

MED12L

826

Q86YW9
MEPHVFETVPHLQSL

LRRTM1

271

Q86UE6
ILMHHPPQVDELDRL

KCTD20

391

Q7Z5Y7
MDLHVFHALRQPDVP

LRP1

3276

Q07954
LIHHQDPLFLDLMGT

CFAP65

546

Q6ZU64
IHQPEDPIPFMIQHL

AK8

36

Q96MA6
DPIPFMIQHLHRDND

AK8

41

Q96MA6
MLILHAVFHMPSPDA

OR52B4

221

Q8NGK2
LHMVLPAHLPFLSPE

FAM205A

276

Q6ZU69
LHMVLPAHLPFLSPE

FAM205BP

6

Q63HN1
APLHLHENPDLAKVM

NCKAP1L

501

P55160
PDNLMHVFHDDLLPL

POMGNT2

161

Q8NAT1
LLHIPALMSPHSAED

ARHGAP32

766

A7KAX9
PAETLNHPFVNMKHL

HIPK3

516

Q9H422
FPMAAPVLVIEADHH

TK2

226

O00142
ATHPPSEDRFLHIME

KDM5A

1471

P29375
GLHAVMEALPFSLLH

PROX2

421

Q3B8N5
MDFIHVPILPLNHAL

PGR

301

P06401
PQHLDERFLLHDMLP

NLGN4Y

111

Q8NFZ3
EAVHEVLMLLPPAHY

CHN2

386

P52757
LDDMQLHQLALHPAP

FRMD1

486

Q8N878
LMSHLQDNIQHADPP

EIF3CL

591

B5ME19
PLPDQAFFVLHNMHS

IL33

211

O95760
DPQSPVFHLHPASME

HYDIN

981

Q4G0P3
MLLLNVPPTHAEVHQ

HEATR5A

981

Q86XA9
MDSELHPLLVQHLPH

BTAF1

1096

O14981
LEFALHLPEHEVMPH

CABLES1

611

Q8TDN4
LNLSQEPAHPAMALH

CHD3

1816

Q12873
PETAIPRELMFHEVH

COQ10A

231

Q96MF6
HPLPIEKHISHFMQN

DENND4C

341

Q5VZ89
IVQTLVHLMFPDHVP

BMP5

401

P22003
LESLVLPSPEHMHQA

LYST

946

Q99698
LRAFLDPPHMLNHDL

MACC1

251

Q6ZN28
HLMTHDALPNLSQAP

LYPD5

111

Q6UWN5
ALQSLTDAMHIPHLF

GRID1

101

Q9ULK0
HEMLDQCPHPAFKPL

DNAH10

4006

Q8IVF4
VLIDERNPHHPMVLD

SCNN1B

151

P51168
HFAVQVVDMLALHLP

IPO4

331

Q8TEX9
PQHLDERSLLHDMLP

NLGN4X

111

Q8N0W4
LHPLFQAMTDPLCHL

NLRP6

716

P59044
LLNPLDSPHHMRQDE

SPOUT1

171

Q5T280
HNNLMSLPHDLFTPL

LRRC4B

286

Q9NT99
PSAEELLTHHFAQLM

MAP3K3

611

Q99759
PELMQHPFFTLHESK

MAP2K6

306

P52564
VHEIPFHFDLMGLLP

SZT2

986

Q5T011
SIFDMLEHFRVHPIP

SH2B1

596

Q9NRF2
DMAPHNPHTLLFEIL

SPATA21

301

Q7Z572
IINDMRDLPNTHPFH

TAF1L

1411

Q8IZX4
LVPEEMHVLLSFSHL

OVCH2

346

Q7RTZ1
ASHHLEPNMDLINLL

RASGRP3

346

Q8IV61
AHHLPIEMDPLIANN

NBEA

2646

Q8NFP9
THLDPAMPFHRALDP

NCOR1

1566

O75376
HRLPMPNLKDELHHS

SELENBP1

61

Q13228
VADLLPHMPHISECL

IQCJ-SCHIP1

471

B3KU38
PPHFVEHIRSTLMFL

NTAN1

261

Q96AB6
ALLPEPNHVMLNHLY

PRKAB1

226

Q9Y478
AHAFLPTMPEDLLAQ

RNF213

4476

Q63HN8
IPSDHLPHFAELMER

TNRC18

861

O15417
HEAFHLLLPHIPPMV

USP35

341

Q9P2H5
TLIEMAQIEPPHHEL

STK10

226

O94804
MESQNLADFPRPVHH

MTHFSD

21

Q2M296
LLLMNNDDRDPPQHH

USF3

1051

Q68DE3
FAQPLPHAHLVIMTT

TMEM86B

191

Q8N661
PAFPHTELANLDDMI

USP9Y

66

O00507
FQHVEMHLRSEHPPL

SF3B3

1141

Q15393
NLLMAFVLHQAGPPH

SLC30A3

191

Q99726
LNFSDHHVIPMPLLK

SLC30A6

351

Q6NXT4
IKELLSMHHQPDPAL

USP24

1656

Q9UPU5
EPQHIPCVLMAFLDH

XPOT

516

O43592
LLMDFHSVPHPPELV

TRPM8

756

Q7Z2W7
PPALNIAVMLGHSHD

GRIN2A

31

Q12879
PEQMFHLDPSLTHTI

NFKB1

11

P19838