Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	mRNA regulatory element binding translation repressor activity	CELF1 CPEB3 CPEB1	1.38e-05	17	56	3	GO:0000900
GeneOntologyMolecularFunction	mRNA 3'-UTR AU-rich region binding	CPEB3 CPSF1 CPEB1	7.25e-05	29	56	3	GO:0035925
GeneOntologyMolecularFunction	histone H3K4me/H3K4me2/H3K4me3 demethylase activity	KDM5C KDM5D	1.15e-04	6	56	2	GO:0034647
GeneOntologyMolecularFunction	mRNA 3'-UTR binding	CELF1 RBMS1 CPEB3 CPSF1 PUM2 CPEB1	1.20e-04	276	56	6	GO:0003730
GeneOntologyMolecularFunction	histone H3K4 demethylase activity	KDM5C KDM5D	2.14e-04	8	56	2	GO:0032453
GeneOntologyMolecularFunction	demethylase activity	ALKBH2 KDM5C KDM5D	2.55e-04	44	56	3	GO:0032451
GeneOntologyMolecularFunction	DNA-binding transcription repressor activity, RNA polymerase II-specific	SCRT2 ZBTB32 SALL1 NFKB1 POU4F1 POU4F2	2.67e-04	320	56	6	GO:0001227
GeneOntologyMolecularFunction	DNA-binding transcription repressor activity	SCRT2 ZBTB32 SALL1 NFKB1 POU4F1 POU4F2	2.95e-04	326	56	6	GO:0001217
GeneOntologyMolecularFunction	2-oxoglutarate-dependent dioxygenase activity	ALKBH2 KDM5C KDM5D	8.07e-04	65	56	3	GO:0016706
GeneOntologyMolecularFunction	dioxygenase activity	ALKBH2 KDM5C KDM5D	2.63e-03	98	56	3	GO:0051213
GeneOntologyMolecularFunction	histone H3 demethylase activity	KDM5C KDM5D	2.79e-03	28	56	2	GO:0141052
GeneOntologyMolecularFunction	histone demethylase activity	KDM5C KDM5D	3.41e-03	31	56	2	GO:0032452
GeneOntologyMolecularFunction	protein demethylase activity	KDM5C KDM5D	3.63e-03	32	56	2	GO:0140457
GeneOntologyMolecularFunction	translation regulator activity, nucleic acid binding	CELF1 CPEB3 CPEB1	3.84e-03	112	56	3	GO:0090079
MousePheno	absent triquetrum	SALL1 SALL4	8.81e-06	2	42	2	MP:0030862
MousePheno	abnormal triquetrum morphology	SALL1 SALL4	2.64e-05	3	42	2	MP:0030861
MousePheno	absent carpal bone	SALL1 SALL4	8.76e-05	5	42	2	MP:0000555
Domain	CEBP_ZZ	CPEB3 CPEB1	4.72e-05	4	53	2	IPR032296
Domain	Lys_sp_deMease-like_dom	KDM5C KDM5D	4.72e-05	4	53	2	IPR013637
Domain	PLU-1	KDM5C KDM5D	4.72e-05	4	53	2	PF08429
Domain	CEBP_ZZ	CPEB3 CPEB1	4.72e-05	4	53	2	PF16366
Domain	RRM_7	CPEB3 CPEB1	4.72e-05	4	53	2	PF16367
Domain	zf-C5HC2	KDM5C KDM5D	7.86e-05	5	53	2	PF02928
Domain	Znf_C5HC2	KDM5C KDM5D	7.86e-05	5	53	2	IPR004198
Domain	JmjN	KDM5C KDM5D	3.50e-04	10	53	2	PF02375
Domain	JmjN	KDM5C KDM5D	3.50e-04	10	53	2	SM00545
Domain	JMJN	KDM5C KDM5D	3.50e-04	10	53	2	PS51183
Domain	JmjN	KDM5C KDM5D	3.50e-04	10	53	2	IPR003349
Domain	Hud_Sxl_RNA	CELF1 RBMS1	3.50e-04	10	53	2	IPR002343
Domain	-	KDM5C KDM5D	8.10e-04	15	53	2	1.10.150.60
Domain	ARID	KDM5C KDM5D	8.10e-04	15	53	2	PF01388
Domain	BRIGHT	KDM5C KDM5D	8.10e-04	15	53	2	SM00501
Domain	ARID_dom	KDM5C KDM5D	8.10e-04	15	53	2	IPR001606
Domain	ARID	KDM5C KDM5D	8.10e-04	15	53	2	PS51011
Domain	POU	POU4F1 POU4F2	9.24e-04	16	53	2	SM00352
Domain	POU_2	POU4F1 POU4F2	9.24e-04	16	53	2	PS00465
Domain	Pou	POU4F1 POU4F2	9.24e-04	16	53	2	PF00157
Domain	POU_dom	POU4F1 POU4F2	9.24e-04	16	53	2	IPR000327
Domain	POU_3	POU4F1 POU4F2	9.24e-04	16	53	2	PS51179
Domain	POU_1	POU4F1 POU4F2	9.24e-04	16	53	2	PS00035
Domain	POU	POU4F1 POU4F2	1.05e-03	17	53	2	IPR013847
Domain	JmjC	KDM5C KDM5D	2.10e-03	24	53	2	PF02373
Domain	-	POU4F1 POU4F2	2.65e-03	27	53	2	1.10.260.40
Domain	Lambda_DNA-bd_dom	POU4F1 POU4F2	3.05e-03	29	53	2	IPR010982
Domain	RRM	CELF1 RBMS1 CPEB3 CPEB1	3.33e-03	217	53	4	SM00360
Domain	JMJC	KDM5C KDM5D	3.71e-03	32	53	2	PS51184
Domain	JmjC_dom	KDM5C KDM5D	3.71e-03	32	53	2	IPR003347
Domain	RRM_dom	CELF1 RBMS1 CPEB3 CPEB1	3.91e-03	227	53	4	IPR000504
Domain	JmjC	KDM5C KDM5D	3.94e-03	33	53	2	SM00558
Domain	RRM	CELF1 RBMS1 CPEB3 CPEB1	4.09e-03	230	53	4	PS50102
Domain	-	CELF1 RBMS1 CPEB3 CPEB1	5.04e-03	244	53	4	3.30.70.330
Domain	Nucleotide-bd_a/b_plait	CELF1 RBMS1 CPEB3 CPEB1	6.13e-03	258	53	4	IPR012677
Domain	Znf_FYVE_PHD	KDM5C ANKIB1 KDM5D	8.40e-03	147	53	3	IPR011011
Pubmed	An atlas of combinatorial transcriptional regulation in mouse and man.	ZNF276 ZBTB32 KDM5C NFKB1 SALL4 ZKSCAN7 POU4F1 POU4F2 KDM5D SSBP4	1.23e-06	877	56	10	20211142
Pubmed	Brn3a and Brn3b knockout mice display unvaried retinal fine structure despite major morphological and numerical alterations of ganglion cells.	POU4F1 POU4F2	2.55e-06	2	56	2	27391320
Pubmed	Short isoform of POU factor Brn-3b can form a heterodimer with Brn-3a that is inactive for octamer motif binding.	POU4F1 POU4F2	2.55e-06	2	56	2	8537352
Pubmed	Roles of Sall4 in the generation of pluripotent stem cells from blastocysts and fibroblasts.	SALL1 SALL4	2.55e-06	2	56	2	19476507
Pubmed	Brn3 transcription factors control terminal osteoclastogenesis.	POU4F1 POU4F2	2.55e-06	2	56	2	17668438
Pubmed	Mouse H-Y encoding Smcy gene and its X chromosomal homolog Smcx.	KDM5C KDM5D	2.55e-06	2	56	2	10441747
Pubmed	GPI-80 Augments NF-κB Activation in Tumor Cells.	VNN2 NFKB1	2.55e-06	2	56	2	34769456
Pubmed	Inefficient purifying selection: the mammalian Y chromosome in the rodent genus Mus.	KDM5C KDM5D	2.55e-06	2	56	2	16416087
Pubmed	Inhibition of neuronal process outgrowth and neuronal specific gene activation by the Brn-3b transcription factor.	POU4F1 POU4F2	2.55e-06	2	56	2	8995448
Pubmed	Duane radial ray syndrome (Okihiro syndrome) maps to 20q13 and results from mutations in SALL4, a new member of the SAL family.	SALL1 SALL4	2.55e-06	2	56	2	12395297
Pubmed	Sall4 is essential for stabilization, but not for pluripotency, of embryonic stem cells by repressing aberrant trophectoderm gene expression.	SALL1 SALL4	2.55e-06	2	56	2	19350679
Pubmed	Differential expression of four members of the POU family of proteins in activated and phorbol 12-myristate 13-acetate-treated Jurkat T cells.	POU4F1 POU4F2	2.55e-06	2	56	2	8234287
Pubmed	Mutations of histone demethylase genes encoded by X and Y chromosomes, Kdm5c and Kdm5d, lead to noncompaction cardiomyopathy in mice.	KDM5C KDM5D	2.55e-06	2	56	2	32081420
Pubmed	Analysis of mutation rates in the SMCY/SMCX genes shows that mammalian evolution is male driven.	KDM5C KDM5D	2.55e-06	2	56	2	9060413
Pubmed	A single amino acid change converts an inhibitory transcription factor into an activator.	POU4F1 POU4F2	2.55e-06	2	56	2	8662774
Pubmed	Autoregulatory sequences are revealed by complex stability screening of the mouse brn-3.0 locus.	POU4F1 POU4F2	2.55e-06	2	56	2	10414983
Pubmed	Brn-3.2: a Brn-3-related transcription factor with distinctive central nervous system expression and regulation by retinoic acid.	POU4F1 POU4F2	2.55e-06	2	56	2	7904822
Pubmed	NT-3 regulates expression of Brn3a but not Brn3b in developing mouse trigeminal sensory neurons.	POU4F1 POU4F2	2.55e-06	2	56	2	9582431
Pubmed	Differential expression and subcellular localization of Copines in mouse retina.	POU4F1 POU4F2	2.55e-06	2	56	2	30866042
Pubmed	Mouse homolog of SALL1, a causative gene for Townes-Brocks syndrome, binds to A/T-rich sequences in pericentric heterochromatin via its C-terminal zinc finger domains.	SALL1 SALL4	2.55e-06	2	56	2	17295837
Pubmed	Identification of a conserved interface between PUF and CPEB proteins.	CPEB3 PUM2	2.55e-06	2	56	2	22496444
Pubmed	A mouse Y chromosome gene encoded by a region essential for spermatogenesis and expression of male-specific minor histocompatibility antigens.	KDM5C KDM5D	2.55e-06	2	56	2	7524912
Pubmed	Brn-3b enhances the pro-apoptotic effects of p53 but not its induction of cell cycle arrest by cooperating in trans-activation of bax expression.	POU4F1 POU4F2	7.63e-06	3	56	2	17145718
Pubmed	Stem cell factor SALL4 represses the transcriptions of PTEN and SALL1 through an epigenetic repressor complex.	SALL1 SALL4	7.63e-06	3	56	2	19440552
Pubmed	Role of the Brn-3 family of POU-domain genes in the development of the auditory/vestibular, somatosensory, and visual systems.	POU4F1 POU4F2	7.63e-06	3	56	2	9598366
Pubmed	No association between POU4F1, POU4F2, ISL1 polymorphisms and normal-tension glaucoma.	POU4F1 POU4F2	7.63e-06	3	56	2	32597291
Pubmed	CPEB3 and CPEB4 in neurons: analysis of RNA-binding specificity and translational control of AMPA receptor GluR2 mRNA.	CPEB3 CPEB1	7.63e-06	3	56	2	17024188
Pubmed	Identification of a mouse male-specific transplantation antigen, H-Y.	KDM5C KDM5D	7.63e-06	3	56	2	7544442
Pubmed	Differential expression of Brn3 transcription factors in intrinsically photosensitive retinal ganglion cells in mouse.	POU4F1 POU4F2	7.63e-06	3	56	2	21935940
Pubmed	Mouse Brn-3 family of POU transcription factors: a new aminoterminal domain is crucial for the oncogenic activity of Brn-3a.	POU4F1 POU4F2	7.63e-06	3	56	2	8290353
Pubmed	Doppel expression is regulated by the Brn-3a and Brn-3b transcription factors.	POU4F1 POU4F2	7.63e-06	3	56	2	15094508
Pubmed	The Brn-3 family of POU-domain factors: primary structure, binding specificity, and expression in subsets of retinal ganglion cells and somatosensory neurons.	POU4F1 POU4F2	7.63e-06	3	56	2	7623109
Pubmed	Systematic identification of intergenic long-noncoding RNAs in mouse retinas using full-length isoform sequencing.	POU4F1 POU4F2	7.63e-06	3	56	2	31286854
Pubmed	Pou4f1 and pou4f2 are dispensable for the long-term survival of adult retinal ganglion cells in mice.	POU4F1 POU4F2	7.63e-06	3	56	2	24736625
Pubmed	CPEB4 is a cell survival protein retained in the nucleus upon ischemia or endoplasmic reticulum calcium depletion.	CPEB3 CPEB1	7.63e-06	3	56	2	20937770
Pubmed	Pou4f2-GFP knock-in mouse line: A model for studying retinal ganglion cell development.	POU4F1 POU4F2	7.63e-06	3	56	2	27532212
Pubmed	The opposite and antagonistic effects of the closely related POU family transcription factors Brn-3a and Brn-3b on the activity of a target promoter are dependent on differences in the POU domain.	POU4F1 POU4F2	7.63e-06	3	56	2	7935408
Pubmed	POU transcription factors Brn-3a and Brn-3b interact with the estrogen receptor and differentially regulate transcriptional activity via an estrogen response element.	POU4F1 POU4F2	7.63e-06	3	56	2	9448000
Pubmed	Sall4 Is Transiently Expressed in the Caudal Wolffian Duct and the Ureteric Bud, but Dispensable for Kidney Development.	SALL1 SALL4	7.63e-06	3	56	2	23825698
Pubmed	Chromosomal localization and sequences of the murine Brn-3 family of developmental control genes.	POU4F1 POU4F2	7.63e-06	3	56	2	8162704
Pubmed	Sall4 controls differentiation of pluripotent cells independently of the Nucleosome Remodelling and Deacetylation (NuRD) complex.	SALL1 SALL4	7.63e-06	3	56	2	27471257
Pubmed	Dre - Cre sequential recombination provides new tools for retinal ganglion cell labeling and manipulation in mice.	POU4F1 POU4F2	7.63e-06	3	56	2	24608965
Pubmed	Distinct roles of transcription factors brn3a and brn3b in controlling the development, morphology, and function of retinal ganglion cells.	POU4F1 POU4F2	7.63e-06	3	56	2	19323995
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	BMP8B FRAS1 ZNF276 COQ4 UBE3B CPSF1 SSBP4 BCL9 MCF2L ADCY7	9.50e-06	1105	56	10	35748872
Pubmed	Novel JARID1C/SMCX mutations in patients with X-linked mental retardation.	KDM5C KDM5D	1.52e-05	4	56	2	16541399
Pubmed	Essential role of POU-domain factor Brn-3c in auditory and vestibular hair cell development.	POU4F1 POU4F2	1.52e-05	4	56	2	9256502
Pubmed	Identification of retinal ganglion cell types and brain nuclei expressing the transcription factor Brn3c/Pou4f3 using a Cre recombinase knock-in allele.	POU4F1 POU4F2	1.52e-05	4	56	2	33135183
Pubmed	Two previously undescribed members of the mouse CPEB family of genes and their inducible expression in the principal cell layers of the hippocampus.	CPEB3 CPEB1	1.52e-05	4	56	2	12871996
Pubmed	Regulation and function of Spalt proteins during animal development.	SALL1 SALL4	1.52e-05	4	56	2	19247946
Pubmed	The vertebrate spalt genes in development and disease.	SALL1 SALL4	1.52e-05	4	56	2	16545361
Pubmed	The X-linked mental retardation gene SMCX/JARID1C defines a family of histone H3 lysine 4 demethylases.	KDM5C KDM5D	1.52e-05	4	56	2	17320160
Pubmed	Morphologies of mouse retinal ganglion cells expressing transcription factors Brn3a, Brn3b, and Brn3c: analysis of wild type and mutant cells using genetically-directed sparse labeling.	POU4F1 POU4F2	1.52e-05	4	56	2	20826176
Pubmed	X- and Y-Linked Chromatin-Modifying Genes as Regulators of Sex-Specific Cancer Incidence and Prognosis.	KDM5C KDM5D	1.52e-05	4	56	2	32732223
Pubmed	A novel X gene with a widely transcribed Y-linked homologue escapes X-inactivation in mouse and human.	KDM5C KDM5D	1.52e-05	4	56	2	7951230
Pubmed	Genetic interactions between Brn3 transcription factors in retinal ganglion cell type specification.	POU4F1 POU4F2	1.52e-05	4	56	2	24116103
Pubmed	Cardiac expression of Brn-3a and Brn-3b POU transcription factors and regulation of Hsp27 gene expression.	POU4F1 POU4F2	2.54e-05	5	56	2	18368538
Pubmed	Multiomic Analysis of Neurons with Divergent Projection Patterns Identifies Novel Regulators of Axon Pathfinding.	POU4F1 POU4F2	2.54e-05	5	56	2	35988153
Pubmed	New mouse lines for the analysis of neuronal morphology using CreER(T)/loxP-directed sparse labeling.	POU4F1 POU4F2	2.54e-05	5	56	2	19924248
Pubmed	Role of transcription factors Brn-3.1 and Brn-3.2 in auditory and visual system development.	POU4F1 POU4F2	2.54e-05	5	56	2	8637595
Pubmed	Disruption of mouse poly(A) polymerase mGLD-2 does not alter polyadenylation status in oocytes and somatic cells.	CPSF1 CPEB1	3.80e-05	6	56	2	17927953
Pubmed	Expression of a large family of POU-domain regulatory genes in mammalian brain development.	POU4F1 POU4F2	3.80e-05	6	56	2	2739723
Pubmed	Sall1, sall2, and sall4 are required for neural tube closure in mice.	SALL1 SALL4	3.80e-05	6	56	2	18818376
Pubmed	The Wilms' tumor gene Wt1 is required for normal development of the retina.	POU4F1 POU4F2	3.80e-05	6	56	2	11889045
Pubmed	Gfi1-Cre knock-in mouse line: A tool for inner ear hair cell-specific gene deletion.	POU4F1 POU4F2	3.80e-05	6	56	2	20533399
Pubmed	Essential but partially redundant roles for POU4F1/Brn-3a and POU4F2/Brn-3b transcription factors in the developing heart.	POU4F1 POU4F2	3.80e-05	6	56	2	28594399
Pubmed	Requirement for Brn-3b in early differentiation of postmitotic retinal ganglion cell precursors.	POU4F1 POU4F2	3.80e-05	6	56	2	9630743
Pubmed	POU domain factor Brn-3b is required for the development of a large set of retinal ganglion cells.	POU4F1 POU4F2	3.80e-05	6	56	2	8632990
Pubmed	Combinatorial expression of Brn3 transcription factors in somatosensory neurons: genetic and morphologic analysis.	POU4F1 POU4F2	3.80e-05	6	56	2	22262898
Pubmed	Brn3b/Brn3c double knockout mice reveal an unsuspected role for Brn3c in retinal ganglion cell axon outgrowth.	POU4F1 POU4F2	3.80e-05	6	56	2	11807038
Pubmed	Requirement for Brn-3c in maturation and survival, but not in fate determination of inner ear hair cells.	POU4F1 POU4F2	5.32e-05	7	56	2	9735355
Pubmed	Substituting mouse transcription factor Pou4f2 with a sea urchin orthologue restores retinal ganglion cell development.	POU4F1 POU4F2	5.32e-05	7	56	2	26962139
Pubmed	Comparative expression analysis of POU4F1, POU4F2 and ISL1 in developing mouse cochleovestibular ganglion neurons.	POU4F1 POU4F2	5.32e-05	7	56	2	24709358
Pubmed	Brn3a controls the soma localization and axonal extension patterns of developing spinal dorsal horn neurons.	POU4F1 POU4F2	7.09e-05	8	56	2	37733805
Pubmed	The murine homolog of SALL4, a causative gene in Okihiro syndrome, is essential for embryonic stem cell proliferation, and cooperates with Sall1 in anorectal, heart, brain and kidney development.	SALL1 SALL4	7.09e-05	8	56	2	16790473
Pubmed	Gene expression in the developing mouse retina by EST sequencing and microarray analysis.	SCRT2 MBLAC2 CELF1 POU4F1	8.30e-05	142	56	4	11812828
Pubmed	Two Pairs of ON and OFF Retinal Ganglion Cells Are Defined by Intersectional Patterns of Transcription Factor Expression.	SALL1 POU4F1 POU4F2	8.75e-05	53	56	3	27210758
Pubmed	The IRAK-1-BCL10-MALT1-TRAF6-TAK1 cascade mediates signaling to NF-kappaB from Toll-like receptor 4.	NFKB1 PELI2	9.10e-05	9	56	2	16831874
Pubmed	Essential Roles of Tbr1 in the Formation and Maintenance of the Orientation-Selective J-RGCs and a Group of OFF-Sustained RGCs in Mouse.	POU4F1 POU4F2	9.10e-05	9	56	2	30995485
Pubmed	Reprogramming amacrine and photoreceptor progenitors into retinal ganglion cells by replacing Neurod1 with Atoh7.	POU4F1 POU4F2	9.10e-05	9	56	2	23293286
Pubmed	Pou3f1 orchestrates a gene regulatory network controlling contralateral retinogeniculate projections.	POU4F1 POU4F2	9.10e-05	9	56	2	37590135
Pubmed	The IRAK-catalysed activation of the E3 ligase function of Pellino isoforms induces the Lys63-linked polyubiquitination of IRAK1.	NFKB1 PELI2	9.10e-05	9	56	2	17997719
Pubmed	Chromosomal organization of mammalian POU domain factors.	POU4F1 POU4F2	9.10e-05	9	56	2	8276396
Pubmed	Sall genes regulate hindlimb initiation in mouse embryos.	SALL1 SALL4	9.10e-05	9	56	2	38386912
Pubmed	A splice variant of the Wilms' tumour suppressor Wt1 is required for normal development of the olfactory system.	POU4F1 POU4F2	9.10e-05	9	56	2	15716344
Pubmed	SALL1 truncated protein expression in Townes-Brocks syndrome leads to ectopic expression of downstream genes.	SALL1 SALL4	9.10e-05	9	56	2	18470945
Pubmed	Characterization of retinal ganglion cell, horizontal cell, and amacrine cell types expressing the neurotrophic receptor tyrosine kinase Ret.	POU4F1 POU4F2	1.14e-04	10	56	2	29218725
Pubmed	Brn3a is a transcriptional regulator of soma size, target field innervation and axon pathfinding of inner ear sensory neurons.	POU4F1 POU4F2	1.14e-04	10	56	2	11493560
Pubmed	RIT2, a neuron-specific small guanosine triphosphatase, is expressed in retinal neuronal cells and its promoter is modulated by the POU4 transcription factors.	POU4F1 POU4F2	1.14e-04	10	56	2	23805044
Pubmed	Regulation of Brn3b by DLX1 and DLX2 is required for retinal ganglion cell differentiation in the vertebrate retina.	POU4F1 POU4F2	1.39e-04	11	56	2	28356311
Pubmed	Human immunodeficiency virus type 1 Tat protein decreases cyclic AMP synthesis in rat microglia cultures.	NFKB1 ADCY7	1.39e-04	11	56	2	11299302
Pubmed	Targeted deletion of the mouse POU domain gene Brn-3a causes selective loss of neurons in the brainstem and trigeminal ganglion, uncoordinated limb movement, and impaired suckling.	POU4F1 POU4F2	1.39e-04	11	56	2	8876243
Pubmed	Requirement for Brn-3.0 in differentiation and survival of sensory and motor neurons.	POU4F1 POU4F2	1.39e-04	11	56	2	8955272
Pubmed	The Ciliary Margin Zone of the Mammalian Retina Generates Retinal Ganglion Cells.	POU4F1 POU4F2	1.39e-04	11	56	2	28009286
Pubmed	Survival Motor Neuron Enhances Pluripotent Gene Expression and Facilitates Cell Reprogramming.	SALL4 POU4F1	1.39e-04	11	56	2	35848514
Pubmed	Brn3a-expressing retinal ganglion cells project specifically to thalamocortical and collicular visual pathways.	POU4F1 POU4F2	1.66e-04	12	56	2	16354917
Pubmed	The embryonic ontogeny of the gonadal somatic cells in mice and monkeys.	SALL1 SALL4	1.66e-04	12	56	2	33951437
Pubmed	Transcription factors SOX4 and SOX11 function redundantly to regulate the development of mouse retinal ganglion cells.	POU4F1 POU4F2	1.66e-04	12	56	2	23649630
Pubmed	Insm1 promotes neurogenic proliferation in delaminated otic progenitors.	POU4F1 POU4F2	1.66e-04	12	56	2	26545349
Pubmed	Ascl1 expression defines a subpopulation of lineage-restricted progenitors in the mammalian retina.	POU4F1 POU4F2	1.66e-04	12	56	2	21771810
Pubmed	Sex differences in structure and expression of the sex chromosome genes CHD1Z and CHD1W in zebra finches.	KDM5C KDM5D	1.96e-04	13	56	2	14660691
Cytoband	13q33.1	TEX30 CCDC168	9.57e-05	12	56	2	13q33.1
Cytoband	12q24.11	ALKBH2 UBE3B	7.53e-04	33	56	2	12q24.11
Cytoband	16q12.1	SALL1 ADCY7	8.00e-04	34	56	2	16q12.1
Cytoband	Ensembl 112 genes in cytogenetic band chr13q33	TEX30 CCDC168	2.08e-03	55	56	2	chr13q33
Cytoband	19q13.1	ZBTB32 CATSPERG	2.08e-03	55	56	2	19q13.1
Cytoband	1q21	ITGA10 BCL9	5.58e-03	91	56	2	1q21
Cytoband	Ensembl 112 genes in cytogenetic band chr16q12	SALL1 ADCY7	7.09e-03	103	56	2	chr16q12
GeneFamily	AT-rich interaction domain containing	KDM5C KDM5D	4.44e-04	15	38	2	418
GeneFamily	POU class homeoboxes and pseudogenes	POU4F1 POU4F2	1.06e-03	23	38	2	523
GeneFamily	PHD finger proteins\|Lysine demethylases	KDM5C KDM5D	1.15e-03	24	38	2	485
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	SCRT2 ZNF276 ZBTB32 SALL1 SALL4 ZKSCAN7	3.58e-03	718	38	6	28
GeneFamily	RNA binding motif containing	CELF1 RBMS1 CPEB3	1.00e-02	213	38	3	725
GeneFamily	PHD finger proteins	KDM5C KDM5D	1.53e-02	90	38	2	88
Disease	syndromic X-linked intellectual disability Claes-Jensen type (implicated_via_orthology)	KDM5C KDM5D	1.97e-05	4	54	2	DOID:0060809 (implicated_via_orthology)
Disease	Polydactyly	FRAS1 SALL1 UBE3B SALL4	6.37e-05	117	54	4	C0152427
Disease	autism spectrum disorder (implicated_via_orthology)	SH3RF2 KDM5C PKP1 KDM5D	1.75e-04	152	54	4	DOID:0060041 (implicated_via_orthology)
Disease	hepatoblastoma (is_marker_for)	SALL1 SALL4	3.40e-04	15	54	2	DOID:687 (is_marker_for)
Disease	syndromic intellectual disability (implicated_via_orthology)	KDM5C KDM5D	3.88e-04	16	54	2	DOID:0050888 (implicated_via_orthology)
Disease	Limb Deformities, Congenital	SALL1 SALL4	4.39e-04	17	54	2	C0206762
Disease	Abnormality of radial ray	SALL1 SALL4	1.67e-03	33	54	2	C4228778
Disease	Congenital small ears	FRAS1 SALL1	2.58e-03	41	54	2	C0152423
Disease	uric acid measurement	FRAS1 ZNF276 NDC1 RBMS1 NFKB1	5.10e-03	610	54	5	EFO_0004761
Disease	carcinoma (implicated_via_orthology)	SALL1 SALL4	6.16e-03	64	54	2	DOID:305 (implicated_via_orthology)
Disease	C-reactive protein measurement	ZNF276 SALL1 CELF1 VPS13C NFKB1 CCDC168 SSBP4	6.20e-03	1206	54	7	EFO_0004458

Protein segments in the cluster

Peptide	Gene	Start	Entry
LPLAHGSLLMMNHPT	ALKBH2	216	Q6NS38
FQETHLGPHMQGNLM	CATSPERG	861	Q6ZRH7
FNMAAGSAPMQLHLR	APOM	71	O95445
MGILLSHANSMMNPI	ADORA3	266	P0DMS8
QNALHNMKVLPGMHH	CELF1	76	Q92879
PMHPNNSHHTMASLD	FCHO2	361	Q0JRZ9
NVHNETSMHLLCMGP	ANKIB1	76	Q9P2G1
NLLLSVLPAHISMGM	ADCY7	231	P51828
SLNINMHHDPFLRSM	DMXL1	1761	Q9Y485
TDLLDMQMHALLHQP	MMP26	66	Q9NRE1
MQMHALLHQPHCGVP	MMP26	71	Q9NRE1
MISPLAQQMSHLSLG	RBMS1	336	P29558
GASHHSMSQPIMVQR	PUM2	51	Q8TB72
LGHLSHPAAAAAMNM	POU4F1	196	Q01851
GMLPLISTMPLHNLH	FRAS1	3346	Q86XX4
NLLAAHSPHMMIGPN	MED12L	311	Q86YW9
LMNLSPSAMKNLLHH	PHKA1	946	P46020
IPQHPATLHSMMVRS	KIAA1109	2901	Q2LD37
QLVTLMNPNTLMSHG	KDM5D	556	Q9BY66
MLQNALTTMLPHHAG	CPSF1	1361	Q10570
LFMCIQPTSHHSPMQ	OR2M7	256	Q8NG81
GLAMAMPLCGHRLNH	OR2Y1	161	Q8NGV0
LGHRVSPLLQAMMAN	OR51J1	266	Q9H342
DHNPSMTHLRLSMGL	LMLN2	726	A0A1B0GTW7
MGINFHHPGTDNIMA	CPEB3	391	Q8NE35
SLQDMMVHQHGPRGV	BCL9	496	O00512
EVHDMLHTLLGMPTN	COQ4	161	Q9Y3A0
NLGDRQLTVMHMPGH	MBLAC2	156	Q68D91
MDNPLMAHLLSTGLH	MCF2L	661	O15068
LGNSSHPAVNMHLGM	ITGA10	96	O75578
HPAVNMHLGMSLLET	ITGA10	101	O75578
SMEGLRHHSPLMRNQ	CPEB1	546	Q9BZB8
AHLSLQMLPGIHMDM	CCDC168	5876	Q8NDH2
NHAILQSLVHLMMPD	BMP8B	346	P34820
LQQHIRMHMGGQIPN	SALL1	781	Q9NSC2
QHMLTHQMRDLPSQL	SALL1	1046	Q9NSC2
LQQHIRMHMGGQIPN	SALL4	641	Q9UJQ4
PNTHLLHVINMLPMH	CFAP47	766	Q6ZTR5
MPSLSHLNLHQNCLM	NRROS	351	Q86YC3
NMSRHPLLHRVMGNQ	PKP1	621	Q13835
HLMNHMNLLPLDSHG	UTP25	496	Q68CQ4
VSMPALAMHLLTHNL	SCRT2	196	Q9NQ03
HMDGLTTNGVLVMHP	PELI2	181	Q9HAT8
NPMHQAALSMAHAHG	POU4F2	226	Q12837
PLVGHNMMMDLLHLH	PNLDC1	251	Q8NA58
HSVMNTHTLPPMNHL	CCT8L1P	166	A6NM43
MGMGVNLLVANTHHV	VNN2	256	O95498
VNHLLGDPMANVAMA	YIF1A	51	O95070
QARAMIHHHLMAATP	nan	21	Q6ZUT4
AAMSAMEPHHVNGSL	SSBP4	316	Q9BWG4
AHNLNVHMSMVHPLT	ZNF276	566	Q8N554
RFQHPSTMHILQPMD	VPS13C	771	Q709C8
DMNLPHLMSLASHLA	TEX30	41	Q5JUR7
RPAMNHICANIMGHL	UBE3B	186	Q7Z3V4
PENHHSMASLAGENM	ZKSCAN7	261	Q9P0L1
NTLNRMVHSPSGRHM	SH3RF2	306	Q8TEC5
ASMQAHMRGHSPSQL	ZBTB32	441	Q9Y2Y4
GHPGHCSLMMLHLLQ	XKR5	61	Q6UX68
QLVTLMNPNTLMSHG	KDM5C	566	P41229
SDQNMMHFHQLTPPL	LIPK	311	Q5VXJ0
HPQQLMHSFIHAAMG	NDC1	111	Q9BTX1
HPNGDGLNAIHLAMM	NFKB1	646	P19838
GLNAIHLAMMSNSLP	NFKB1	651	P19838