Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	ERAP1-like_C_dom	ANPEP ERAP2	7.91e-05	8	32	2	IPR024571
Domain	ERAP1_C	ANPEP ERAP2	7.91e-05	8	32	2	PF11838
Domain	Peptidase_M1	ANPEP ERAP2	1.86e-04	12	32	2	IPR001930
Domain	Peptidase_M1	ANPEP ERAP2	2.19e-04	13	32	2	PF01433
Domain	Peptidase_M1_N	ANPEP ERAP2	2.19e-04	13	32	2	IPR014782
Domain	Integrin_dom	ITGA4 ITGB8	8.32e-04	25	32	2	IPR032695
Domain	TF_fork_head_CS_1	FOXO1 FOXO6	2.93e-03	47	32	2	IPR018122
Domain	FORK_HEAD_3	FOXO1 FOXO6	3.18e-03	49	32	2	PS50039
Domain	FH	FOXO1 FOXO6	3.18e-03	49	32	2	SM00339
Domain	FORK_HEAD_1	FOXO1 FOXO6	3.18e-03	49	32	2	PS00657
Domain	FORK_HEAD_2	FOXO1 FOXO6	3.18e-03	49	32	2	PS00658
Domain	Forkhead	FOXO1 FOXO6	3.18e-03	49	32	2	PF00250
Domain	Fork_head_dom	FOXO1 FOXO6	3.18e-03	49	32	2	IPR001766
Domain	-	ITGB8 CACNA2D3	7.11e-03	74	32	2	3.40.50.410
Domain	-	CHSY1 HAS3	8.47e-03	81	32	2	3.90.550.10
Domain	VWFA	ITGB8 CACNA2D3	8.67e-03	82	32	2	PS50234
Domain	VWA	ITGB8 CACNA2D3	9.08e-03	84	32	2	SM00327
Domain	Nucleotide-diphossugar_trans	CHSY1 HAS3	9.93e-03	88	32	2	IPR029044
Domain	WD_REPEATS_1	EML5 PALB2 WDR44	1.18e-02	278	32	3	PS00678
Domain	WD_REPEATS_2	EML5 PALB2 WDR44	1.19e-02	279	32	3	PS50082
Domain	WD_REPEATS_REGION	EML5 PALB2 WDR44	1.19e-02	279	32	3	PS50294
Domain	ZINC_PROTEASE	ANPEP ERAP2	1.22e-02	98	32	2	PS00142
Domain	VWF_A	ITGB8 CACNA2D3	1.24e-02	99	32	2	IPR002035
Pathway	REACTOME_AKT_PHOSPHORYLATES_TARGETS_IN_THE_NUCLEUS	FOXO1 FOXO6	1.57e-04	10	27	2	M27095
Pathway	REACTOME_AKT_PHOSPHORYLATES_TARGETS_IN_THE_NUCLEUS	FOXO1 FOXO6	1.57e-04	10	27	2	MM14778
Pathway	REACTOME_REGULATION_OF_LOCALIZATION_OF_FOXO_TRANSCRIPTION_FACTORS	FOXO1 FOXO6	2.30e-04	12	27	2	MM15657
Pathway	REACTOME_REGULATION_OF_LOCALIZATION_OF_FOXO_TRANSCRIPTION_FACTORS	FOXO1 FOXO6	2.30e-04	12	27	2	M27939
Pathway	WP_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY	ITGA4 ITGB8 CACNA2D3	3.71e-04	74	27	3	M39462
Pathway	KEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC	ITGA4 ITGB8 CACNA2D3	3.71e-04	74	27	3	M16376
Pathway	PID_INTEGRIN5_PATHWAY	ITGA4 ITGB8	4.72e-04	17	27	2	M212
Pathway	KEGG_HYPERTROPHIC_CARDIOMYOPATHY_HCM	ITGA4 ITGB8 CACNA2D3	5.20e-04	83	27	3	M8728
Pathway	KEGG_DILATED_CARDIOMYOPATHY	ITGA4 ITGB8 CACNA2D3	6.59e-04	90	27	3	M835
Pathway	REACTOME_FOXO_MEDIATED_TRANSCRIPTION	FOXO1 FOXO6	7.97e-04	22	27	2	MM15656
Pathway	KEGG_MEDICUS_REFERENCE_ITGA_B_RHOGAP_RHOA_SIGNALING_PATHWAY	ITGA4 ITGB8	8.72e-04	23	27	2	M47537
Pathway	KEGG_MEDICUS_REFERENCE_ITGA_B_RHOGEF_RHOA_SIGNALING_PATHWAY	ITGA4 ITGB8	8.72e-04	23	27	2	M47720
Pathway	KEGG_MEDICUS_REFERENCE_ITGA_B_FAK_CDC42_SIGNALING_PATHWAY	ITGA4 ITGB8	1.12e-03	26	27	2	M47719
Pathway	REACTOME_CONSTITUTIVE_SIGNALING_BY_AKT1_E17K_IN_CANCER	FOXO1 FOXO6	1.12e-03	26	27	2	M27558
Pathway	PID_INTEGRIN_CS_PATHWAY	ITGA4 ITGB8	1.12e-03	26	27	2	M47
Pathway	KEGG_MEDICUS_REFERENCE_ITGA_B_RHOG_RAC_SIGNALING_PATHWAY	ITGA4 ITGB8	1.29e-03	28	27	2	M47655
Pathway	KEGG_MEDICUS_REFERENCE_ITGA_B_TALIN_VINCULIN_SIGNALING_PATHWAY	ITGA4 ITGB8	1.49e-03	30	27	2	M47724
Pathway	KEGG_MEDICUS_REFERENCE_ITGA_B_FAK_RAC_SIGNALING_PATHWAY	ITGA4 ITGB8	1.49e-03	30	27	2	M47718
Pathway	REACTOME_FOXO_MEDIATED_TRANSCRIPTION_OF_OXIDATIVE_STRESS_METABOLIC_AND_NEURONAL_GENES	FOXO1 FOXO6	1.49e-03	30	27	2	M27941
Pathway	WP_LEUKOCYTEINTRINSIC_HIPPO_PATHWAY_FUNCTIONS	FOXO1 FOXO6	2.02e-03	35	27	2	M39430
Pubmed	Silencing FUT4 Inhibits the Progression of Osteosarcoma through Activation of FOXO1.	FOXO1 FUT4	8.20e-07	2	32	2	38343056
Pubmed	FoxO6, a novel member of the FoxO class of transcription factors with distinct shuttling dynamics.	FOXO1 FOXO6	2.46e-06	3	32	2	12857750
Pubmed	Candidate gene study of FOXO1, FOXO4, and FOXO6 reveals no association with human longevity in Germans.	FOXO1 FOXO6	2.46e-06	3	32	2	21388494
Pubmed	BRCA1 and RNAi factors promote repair mediated by small RNAs and PALB2-RAD52.	RAD52 PALB2	2.46e-06	3	32	2	33536619
Pubmed	Human neutrophils secrete bioactive paucimannosidic proteins from azurophilic granules into pathogen-infected sputum.	C4A ANPEP IGHM	3.12e-06	31	32	3	25645918
Pubmed	Diminished CD10, CD13, and CD15 expression in a differentiated granulocyte population in CML.	FUT4 ANPEP	4.92e-06	4	32	2	17662271
Pubmed	Prognostic value of immunophenotyping in elderly patients with acute myeloid leukemia: a single-institution experience.	FUT4 ANPEP	4.92e-06	4	32	2	18085638
Pubmed	Spatial and temporal expression of FoxO transcription factors in the developing and adult murine brain.	FOXO1 FOXO6	4.92e-06	4	32	2	16326148
Pubmed	A Novel Mechanism for Generating the Interferon Signature in Lupus: Opsonization of Dead Cells by Complement and IgM.	C4A IGHM	4.92e-06	4	32	2	27274010
Pubmed	B cell subsets contribute to renal injury and renal protection after ischemia/reperfusion.	C4A IGHM	1.23e-05	6	32	2	20810984
Pubmed	FoxO transcription factors suppress Myc-driven lymphomagenesis via direct activation of Arf.	FOXO1 FOXO6	1.23e-05	6	32	2	17974917
Pubmed	FoxO transcription factors; Regulation by AKT and 14-3-3 proteins.	FOXO1 FOXO6	1.23e-05	6	32	2	21708191
Pubmed	Predominant role of IgM-dependent activation of the classical pathway in the clearance of dying cells by murine bone marrow-derived macrophages in vitro.	C4A IGHM	1.23e-05	6	32	2	15597324
Pubmed	The transcription factor Foxo1 controls germinal center B cell proliferation in response to T cell help.	FOXO1 IGHM	1.72e-05	7	32	2	28351982
Pubmed	Impaired antibody response causes persistence of prototypic T cell-contained virus.	C4A IGHM	2.29e-05	8	32	2	19355789
Pubmed	Surviving mousepox infection requires the complement system.	C4A IGHM	2.94e-05	9	32	2	19112490
Pubmed	Let-7 microRNA-dependent control of leukotriene signaling regulates the transition of hematopoietic niche in mice.	ITGA4 DROSHA	3.67e-05	10	32	2	28743859
Pubmed	Cyclin D3 Governs Clonal Expansion of Dark Zone Germinal Center B Cells.	FOXO1 IGHM	3.67e-05	10	32	2	33207194
Pubmed	Identification and Herc5-mediated ISGylation of novel target proteins.	FUT4 PITX2	5.38e-05	12	32	2	16884686
Pubmed	Forkhead factor FoxO1 is essential for placental morphogenesis in the developing embryo.	FOXO1 ITGA4	5.38e-05	12	32	2	21930913
Pubmed	Foxo1 is a downstream effector of Isl1 in direct pathway striatal projection neuron development within the embryonic mouse telencephalon.	FOXO1 FOXO6	5.38e-05	12	32	2	28213137
Pubmed	FoxO6 regulates Hippo signaling and growth of the craniofacial complex.	FOXO6 PITX2	7.41e-05	14	32	2	30286078
Pubmed	Identification of forkhead transcription factors in cortical and dopaminergic areas of the adult murine brain.	FOXO1 FOXO6	9.76e-05	16	32	2	16376864
Pubmed	The Role of Sorting Nexin 17 in Cardiac Development.	ITGA4 PITX2	1.39e-04	19	32	2	34988124
Pubmed	Antibodies and complement are key drivers of thrombosis.	C4A IGHM	2.05e-04	23	32	2	39226900
Pubmed	Foxo1 Is Required for Normal Somatotrope Differentiation.	FOXO1 PITX2	2.24e-04	24	32	2	27631552
Pubmed	FOXO Transcription Factors Are Required for Normal Somatotrope Function and Growth.	FOXO1 FOXO6	2.24e-04	24	32	2	34971379
Pubmed	Premature Expression of FOXO1 in Developing Mouse Pituitary Results in Anterior Lobe Hypoplasia.	FOXO1 PITX2	2.84e-04	27	32	2	29796621
Pubmed	Perlecan regulates pericyte dynamics in the maintenance and repair of the blood-brain barrier.	ITGA4 ITGB8	2.84e-04	27	32	2	31541017
Pubmed	Genetic variation in genes interacting with BRCA1/2 and risk of breast cancer in the Cypriot population.	RAD52 PALB2	4.25e-04	33	32	2	19714462
Pubmed	Human colostrum: identification of minor proteins in the aqueous phase by proteomics.	C4A ANPEP IGHM	4.46e-04	162	32	3	16502470
Pubmed	Dopaminergic control of autophagic-lysosomal function implicates Lmx1b in Parkinson's disease.	FOXO1 PITX2	4.52e-04	34	32	2	25915474
Pubmed	Genome-wide association analyses identify multiple loci associated with central corneal thickness and keratoconus.	FOXO1 CHSY1	4.79e-04	35	32	2	23291589
Pubmed	Screening for N-glycosylated proteins by liquid chromatography mass spectrometry.	C4A IGHM	8.64e-04	47	32	2	14760718
GeneFamily	Aminopeptidases\|CD molecules	ANPEP ERAP2	3.33e-04	17	29	2	104
GeneFamily	Forkhead boxes	FOXO1 FOXO6	2.15e-03	43	29	2	508
Coexpression	GU_PDEF_TARGETS_DN	FOXO1 KRT75 ITGB8	1.58e-05	40	32	3	M10480
Coexpression	WIEDERSCHAIN_TARGETS_OF_BMI1_AND_PCGF2	ITGA4 KRT75 ITGB8	4.62e-05	57	32	3	M2316
Coexpression	GCNP_SHH_UP_EARLY.V1_DN	NSUN3 ITGA4 LIN9 PITX2	4.97e-05	167	32	4	M2638
ToppCell	Substantia_nigra-Endothelial-MURAL-M1(Rgs5Acta2)-M1_2-MURAL_Mural.Rgs5Acta2.Kcnj8_(Mural.Rgs5Acta2.Kcnj8)-\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	ITGA4 BCL2L15 ANPEP ROR1	1.63e-06	120	32	4	3e1ae5a5422729d484a90d72f779833fe3473fa8
ToppCell	Substantia_nigra-Endothelial-MURAL-M1(Rgs5Acta2)-M1_2-MURAL_Mural.Rgs5Acta2.Kcnj8_(Mural.Rgs5Acta2.Kcnj8)\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	ITGA4 BCL2L15 ANPEP ROR1	1.63e-06	120	32	4	24d5e86931a857bb87684392172bf04294a1a46a
ToppCell	Substantia_nigra-Endothelial-MURAL-M1(Rgs5Acta2)-M1_2\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	ITGA4 BCL2L15 ANPEP ROR1	1.63e-06	120	32	4	e60b74758c8290919b326904ad841962256b72ec
Drug	15d-PGJ2; Down 200; 10uM; HL60; HT_HG-U133A	ITGA4 FUT4 GRAMD4 PALB2 CACNA2D3	5.51e-06	184	32	5	2691_DN
Disease	eosinophil percentage of granulocytes	FOXO1 RAD52 PLB1 ITGB8	1.16e-04	234	32	4	EFO_0007996
Disease	visfatin measurement	PLB1 GRAMD4	1.53e-04	17	32	2	EFO_0801230
Disease	oxalate measurement	ITGB8 CACNA2D3	5.54e-04	32	32	2	EFO_0010517
Disease	Inflammatory Bowel Diseases	ITGA4 ITGB8	6.63e-04	35	32	2	C0021390
Disease	Nephroblastoma	DROSHA PALB2	7.01e-04	36	32	2	C0027708
Disease	monocyte percentage of leukocytes	FOXO1 CHSY1 ITGA4 LIN9 RBMS1	1.06e-03	731	32	5	EFO_0007989
Disease	neutrophil count, eosinophil count	CHSY1 ITGA4 LIN9	1.58e-03	213	32	3	EFO_0004833, EFO_0004842
Disease	attention deficit hyperactivity disorder, substance abuse, antisocial behaviour measurement	NSUN3 NRAP FOXO6 ERAP2 CACNA2D3	1.60e-03	801	32	5	EFO_0003888, EFO_0007052, MONDO_0002491
Disease	neutrophil count, basophil count	CHSY1 ITGA4 LIN9	1.82e-03	224	32	3	EFO_0004833, EFO_0005090
Disease	neutrophil percentage of granulocytes	RAD52 PLB1 ITGB8	1.91e-03	228	32	3	EFO_0007994
Disease	basophil count, eosinophil count	FOXO1 PLB1 ITGB8	2.24e-03	241	32	3	EFO_0004842, EFO_0005090
Disease	granulocyte count	CHSY1 ITGA4 LIN9	2.60e-03	254	32	3	EFO_0007987
Disease	allergic disease	FOXO1 PLB1 ITGB8	2.72e-03	258	32	3	MONDO_0005271
Disease	granulocyte percentage of myeloid white cells	FOXO1 CHSY1 ITGA4	3.02e-03	268	32	3	EFO_0007997

Protein segments in the cluster

Peptide	Gene	Start	Entry
TNFVKNLSALSDWYS	GRAMD4	216	Q6IC98
SATTLDQSKAWNRYR	ANPEP	61	P15144
EAASSYQEAWSTLRK	ADAT1	471	Q9BUB4
SSNSGWDQLSKTNLY	RBMS1	51	P29558
AKSGSWDLQTYSADQ	RAD52	381	P43351
NDRSWLFSSDSQKAS	NSUN3	216	Q9H649
KEGSLSNTWNEKYSS	LIN9	21	Q5TKA1
ANAANLSEKLYKSSW	NRAP	776	Q86VF7
SNLFNWTLSYRADSD	FUT4	311	P22083
KSSRRNAWGNLSYAD	FOXO6	81	A8MYZ6
SSKQNLWDALYTALE	DRC1	671	Q96MC2
RHQKEDSLSWSNSAY	PALB2	566	Q86YC2
DSLSWSNSAYLSLDD	PALB2	571	Q86YC2
WNSNKIKSSSDYRVS	ITGB8	711	P26012
KSSSSRRNAWGNLSY	FOXO1	151	Q12778
SWKYKNNSDISSTRG	IGHM	41	P01871
AYWTSLALNKSENSD	CACNA2D3	706	Q8IZS8
ENRRDSWSYINSKSN	ITGA4	1016	P13612
SYRNAKNDDLWSSLS	ERAP2	486	Q6P179
RWQNSKGDLSDSSKY	IGFN1	61	Q86VF2
QILNKYDSWISFLSS	HAS3	246	O00219
HLDWSSDSRYLQTND	EML5	456	Q05BV3
KADGSYAAWLSRDSS	C4A	1061	P0C0L4
RWSDNQSSGKDKNYT	DROSHA	371	Q9NRR4
YNNWAAKGLTSASLS	PITX2	176	Q99697
WNSLLASSRYSEQES	PLB1	261	Q6P1J6
SKTWCAQDSSLAYER	BCL2L15	96	Q5TBC7
WLEKNDPSYSKSSNN	CHSY1	781	Q86X52
WNISSELNKDSYLTL	ROR1	46	Q01973
WFSDTRYNQRNSKSN	ZHX1	511	Q9UKY1
LDLSWSKNYFLLSSS	WDR44	611	Q5JSH3
ESDYFASDSNQWLSK	TRIP4	286	Q15650
ANRSRAEAESWYQTK	KRT75	331	O95678