Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	DNA-binding transcription factor activity, RNA polymerase II-specific	ZNF355P HOXA6 HINFP ZNF33B ZNF569 ZHX2 ADNP LEF1 ZNF709 ZNF568 ZNF682 ZNF669 ZNF44	3.14e-05	1412	50	13	GO:0000981
GeneOntologyMolecularFunction	RNA polymerase II transcription regulatory region sequence-specific DNA binding	ZNF355P HOXA6 HINFP ZNF33B ZNF569 ADNP LEF1 ZNF709 ZNF568 ZNF682 ZNF669 ZNF44	1.98e-04	1459	50	12	GO:0000977
GeneOntologyMolecularFunction	calcium-dependent protein serine/threonine kinase activity	PRKCA MAPKAPK5	2.73e-04	10	50	2	GO:0009931
Domain	zf-C2H2	HINFP ZNF33B ZNF569 ZHX2 ADNP ZNF709 ZNF568 ZNF682 ZNF669 ZNF44	8.45e-06	693	48	10	PF00096
Domain	ZINC_FINGER_C2H2_2	HINFP ZNF33B ZNF569 ZHX2 ADNP ZNF709 ZNF568 ZNF682 ZNF669 ZNF44	2.23e-05	775	48	10	PS50157
Domain	ZINC_FINGER_C2H2_1	HINFP ZNF33B ZNF569 ZHX2 ADNP ZNF709 ZNF568 ZNF682 ZNF669 ZNF44	2.28e-05	777	48	10	PS00028
Domain	Znf_C2H2-like	HINFP ZNF33B ZNF569 ZHX2 ADNP ZNF709 ZNF568 ZNF682 ZNF669 ZNF44	2.80e-05	796	48	10	IPR015880
Domain	Znf_C2H2	HINFP ZNF33B ZNF569 ZHX2 ADNP ZNF709 ZNF568 ZNF682 ZNF669 ZNF44	3.09e-05	805	48	10	IPR007087
Domain	ZnF_C2H2	HINFP ZNF33B ZNF569 ZHX2 ADNP ZNF709 ZNF568 ZNF682 ZNF669 ZNF44	3.19e-05	808	48	10	SM00355
Domain	KRAB	ZNF33B ZNF569 ZNF709 ZNF568 ZNF682 ZNF669 ZNF44	3.36e-05	358	48	7	PS50805
Domain	KRAB	ZNF33B ZNF569 ZNF709 ZNF568 ZNF682 ZNF669 ZNF44	3.36e-05	358	48	7	PF01352
Domain	KRAB	ZNF33B ZNF569 ZNF709 ZNF568 ZNF682 ZNF669 ZNF44	4.07e-05	369	48	7	SM00349
Domain	KRAB	ZNF33B ZNF569 ZNF709 ZNF568 ZNF682 ZNF669 ZNF44	4.14e-05	370	48	7	IPR001909
Domain	Znf_C2H2/integrase_DNA-bd	HINFP ZNF33B ZNF569 ADNP ZNF709 ZNF568 ZNF682 ZNF669 ZNF44	5.86e-05	694	48	9	IPR013087
Domain	zf-C2H2_6	ZNF569 ZNF709 ZNF568 ZNF682 ZNF669 ZNF44	1.46e-04	314	48	6	PF13912
Domain	-	HINFP ZNF33B ZNF569 ZNF709 ZNF568 ZNF682 ZNF669 ZNF44	3.05e-04	679	48	8	3.30.160.60
Domain	Znf_FYVE_PHD	ZFYVE16 JADE3 KDM7A	6.38e-03	147	48	3	IPR011011
Pubmed	LUZP1 and the tumor suppressor EPLIN modulate actin stability to restrict primary cilia formation.	LIMA1 MYO5A	6.32e-06	3	51	2	32496561
Pubmed	Exogenous protein kinases A and C, but not endogenous prostasome-associated protein kinase, phosphorylate semenogelins I and II from human semen.	SEMG2 PRKCA	1.26e-05	4	51	2	12399526
Pubmed	Transcriptome analysis of mouse stem cells and early embryos.	HINFP TCP1 SCMH1 ZC3H4 KIF16B BIRC6	1.50e-05	363	51	6	14691545
Pubmed	NLK phosphorylates Raptor to mediate stress-induced mTORC1 inhibition.	RICTOR LEF1	4.41e-05	7	51	2	26588989
Pubmed	Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity.	UTP25 JADE3 ZC3H4 PRKCA IGSF9B NUP188 ADNP MAPKAPK5	5.01e-05	910	51	8	36736316
Pubmed	Rapid and efficient cloning of cDNAs encoding Krüppel-like zinc finger proteins by degenerate PCR.	ZNF355P ZNF569 ZNF682	5.22e-05	49	51	3	9630514
Pubmed	A High-Density Human Mitochondrial Proximity Interaction Network.	CKB UPF2 TCP1 ZC3H4 ATP6AP2 MRPS24 DNAJC11 KIF16B NUP188 BIRC6	5.36e-05	1496	51	10	32877691
Pubmed	Essential function of TORC2 in PKC and Akt turn motif phosphorylation, maturation and signalling.	PRKCA RICTOR	5.87e-05	8	51	2	18566587
Pubmed	mTORC2 interactome and localization determine aggressiveness of high-grade glioma cells through association with gelsolin.	LIMA1 MYO5A TCP1 PRKCA RICTOR	9.43e-05	312	51	5	37120454
Pubmed	Nuclear actin interactome analysis links actin to KAT14 histone acetyl transferase and mRNA splicing.	CKB LIMA1 TCP1 RBBP6 ZC3H4 ADNP	9.52e-05	506	51	6	30890647
Pubmed	Identifying biological pathways that underlie primordial short stature using network analysis.	CKB LIMA1 MYO5A TCP1 ZC3H4 PRKCA NUP188 ADNP	1.14e-04	1024	51	8	24711643
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	JADE3 ZC3H4 KIF16B KDM7A NUP188 ADNP	1.21e-04	529	51	6	14621295
Pubmed	Tagging genes with cassette-exchange sites.	LIMA1 UTP25 DNAJC11 KDM7A BIRC6	1.31e-04	335	51	5	15741177
Pubmed	Syndecan-4 regulates subcellular localization of mTOR Complex2 and Akt activation in a PKCalpha-dependent manner in endothelial cells.	PRKCA RICTOR	1.38e-04	12	51	2	18851840
Pubmed	Menin and Menin-Associated Proteins Coregulate Cancer Energy Metabolism.	UPF2 RBBP6 ZC3H4 NUP188 ADNP	1.43e-04	341	51	5	32971831
Pubmed	Acetylation-Mimic Mutation of TRIM28-Lys304 to Gln Attenuates the Interaction with KRAB-Zinc-Finger Proteins and Affects Gene Expression in Leukemic K562 Cells.	ZNF33B ZNF569 ZNF669 ZNF44	1.46e-04	181	51	4	37372979
Pubmed	mTOR controls embryonic and adult myogenesis via mTORC1.	PRKCA RICTOR	1.63e-04	13	51	2	30872276
Pubmed	FGFR2 is associated with hair thickness in Asian populations.	MYO5A LEF1	1.63e-04	13	51	2	19590514
Pubmed	mTORC2 can associate with ribosomes to promote cotranslational phosphorylation and stability of nascent Akt polypeptide.	PRKCA RICTOR	1.90e-04	14	51	2	21045808
Pubmed	Human transcription factor protein interaction networks.	CKB LIMA1 MYO5A TCP1 RBBP6 MRPS24 ZHX2 ADNP ZNF709	2.08e-04	1429	51	9	35140242
Pubmed	Voltage-dependent conformational changes of Kv1.3 channels activate cell proliferation.	CKB ORC1 TCP1 RBBP6	2.49e-04	208	51	4	33230847
Pubmed	Human POGZ modulates dissociation of HP1alpha from mitotic chromosome arms through Aurora B activation.	ZNF569 ADNP ZNF568	2.51e-04	83	51	3	20562864
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	ORC1 UTP25 MYO5A RBBP6 ATP6AP2 SIPA1L3 DNAJC11 RICTOR ZHX2	2.94e-04	1497	51	9	31527615
Pubmed	De novo lumen formation and elongation in the developing nephron: a central role for afadin in apical polarity.	PRKCA LEF1	3.18e-04	18	51	2	23487309
Pubmed	Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.	NLN ZC3H4 SIPA1L3 BIRC6	3.36e-04	225	51	4	12168954
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	CKB UTP25 MYO5A NUP188 ADNP BIRC6	3.76e-04	653	51	6	22586326
Pubmed	Activation of the c-H-ras proto-oncogene by retrovirus insertion and chromosomal rearrangement in a Moloney leukemia virus-induced T-cell leukemia.	ZNF355P ZNF569	3.94e-04	20	51	2	2542606
Pubmed	Prorenin receptor is critical for nephron progenitors.	ATP6AP2 LEF1	3.94e-04	20	51	2	26658320
Pubmed	Emergence of the ZNF91 Krüppel-associated box-containing zinc finger gene family in the last common ancestor of anthropoidea.	ZNF355P ZNF569	3.94e-04	20	51	2	7479878
Pubmed	N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.	CKB LIMA1 ZFYVE16 TCP1 RBBP6 ZC3H4 ADNP	4.07e-04	934	51	7	33916271
Pubmed	Class 5 transmembrane semaphorins control selective Mammalian retinal lamination and function.	PLXNA3 PRKCA	4.35e-04	21	51	2	21835343
Pubmed	Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.	LIMA1 UPF2 MYO5A TCP1 RBBP6 SIPA1L3 DNAJC11 ADNP	4.55e-04	1257	51	8	36526897
Pubmed	Characterization and mapping of human genes encoding zinc finger proteins.	ZNF569 ZNF44	4.78e-04	22	51	2	1946370
Pubmed	Clustering of C2-H2 zinc finger motif sequences within telomeric and fragile site regions of human chromosomes.	ZNF569 ZNF44	4.78e-04	22	51	2	1505991
Pubmed	Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions.	LIMA1 SIPA1L3 DNAJC11 RICTOR BIRC6	4.90e-04	446	51	5	24255178
Pubmed	Identification of multi-SH3 domain-containing protein interactome in pancreatic cancer: a yeast two-hybrid approach.	TCP1 RBBP6 BIRC6	5.15e-04	106	51	3	18654987
Pubmed	ARHGAP24 represses β-catenin transactivation-induced invasiveness in hepatocellular carcinoma mainly by acting as a GTPase-independent scaffold.	CKB LIMA1 DNAJC11 ZNF568 ZNF682	5.16e-04	451	51	5	36168627
Pubmed	SOX9-COL9A3-dependent regulation of choroid plexus epithelial polarity governs blood-cerebrospinal fluid barrier integrity.	PRKCA SLC4A2	5.23e-04	23	51	2	33526661
Pubmed	Systematically defining selective autophagy receptor-specific cargo using autophagosome content profiling.	CKB LIMA1 ZFYVE16 TCP1 RBBP6 ATP6AP2 NUP188 BIRC6	5.60e-04	1297	51	8	33545068
Pubmed	Constitutive activation of canonical Wnt signaling disrupts choroid plexus epithelial fate.	LEF1 SLC4A2	5.70e-04	24	51	2	35110543
Pubmed	Histone methyltransferase DOT1L coordinates AR and MYC stability in prostate cancer.	CKB MYO5A TCP1 NUP188	6.13e-04	264	51	4	32814769
Pubmed	A neomorphic cancer cell-specific role of MAGE-A4 in trans-lesion synthesis.	LIMA1 TCP1 SIPA1L3	7.04e-04	118	51	3	27377895
Pubmed	DNA polymerase POLD1 promotes proliferation and metastasis of bladder cancer by stabilizing MYC.	CKB TCP1 KIF16B	7.04e-04	118	51	3	37105989
Pubmed	mTORC1 and mTORC2 regulate skin morphogenesis and epidermal barrier formation.	PRKCA RICTOR	7.23e-04	27	51	2	27807348
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	ORC1 UPF2 MYO5A TCP1 PRKCA RICTOR ADNP BIRC6	7.38e-04	1353	51	8	29467282
Pubmed	Regulator of sex-limitation (Rsl) encodes a pair of KRAB zinc-finger genes that control sexually dimorphic liver gene expression.	ZNF355P ZNF682	8.35e-04	29	51	2	14563677
Pubmed	Global Interactome Mapping of Mitochondrial Intermembrane Space Proteases Identifies a Novel Function for HTRA2.	MRPS24 DNAJC11 PRKCA RICTOR BIRC6	9.36e-04	515	51	5	31617661
Pubmed	Multiple genes encoding zinc finger domains are expressed in human T cells.	ZNF33B ZNF44	9.54e-04	31	51	2	2288909
Pubmed	Biochemical and computational analysis of LNX1 interacting proteins.	MRPS24 PRKCA	1.02e-03	32	51	2	22087225
Pubmed	Sf3b4 regulates chromatin remodeler splicing and Hox expression.	HOXA6 SCMH1	1.02e-03	32	51	2	37167859
Pubmed	KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.	CKB LIMA1 UPF2 MYO5A TCP1 SIPA1L3 PRKCA OPHN1	1.06e-03	1431	51	8	37142655
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	PLXNA3 ORC1 BTBD7 SIPA1L3 NUP188 MAPKAPK5 BIRC6	1.10e-03	1105	51	7	35748872
Pubmed	mTOR plays a pivotal role in multiple processes of enamel organ development principally through the mTORC1 pathway and in part via regulating cytoskeleton dynamics.	RICTOR LEF1	1.15e-03	34	51	2	32866472
Pubmed	Development of an efficient screening system to identify novel bone metabolism-related genes using the exchangeable gene trap mutagenesis mouse models.	LIMA1 SLC38A4	1.22e-03	35	51	2	28106071
Pubmed	Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways.	CKB ORC1 LIMA1 MYO5A NUP188	1.40e-03	564	51	5	21565611
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	HINFP ZNF33B ZNF569 ZHX2 ZNF709 ZNF568 ZNF682 ZNF669 ZNF44	2.11e-05	718	40	9	28
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZHX2 ADNP	4.92e-04	15	40	2	529
ToppCell	Tracheal-NucSeq\|Tracheal / Cell types per location group and 10X technology with lineage, and cell group designations	SCMH1 SIPA1L3 PRKCA ZHX2 BIRC6 OPHN1	1.06e-07	199	51	6	94b94b17ca18b8dc27b91da1f2ccf89e03cc7035
ToppCell	TCGA-Pancreas-Primary_Tumor-Pancreatic_Adenocarcinoma-Ductal_Adenocarcinoma-1\|TCGA-Pancreas / Sample_Type by Project: Shred V9	UPF2 JADE3 RBBP6 KIF16B BIRC6	2.30e-06	186	51	5	03db813598b67b1e08f759758a1c2023396921fa
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Cortical_Collecting_Duct_Intercalated_Cell_Type_A\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	CKB LIMA1 CCBE1 ATP6AP2 LEF1	2.36e-06	187	51	5	7b0168bdaa7c6c6b39878aff6a17f0943189a380
ToppCell	Bronchial-NucSeq\|Bronchial / Cell types per location group and 10X technology with lineage, and cell group designations	SCMH1 SIPA1L3 PRKCA ZHX2 OPHN1	2.98e-06	196	51	5	ab53c742866945545a92e2e61850d63c80d9a2a6
ToppCell	Hippocampus-Neuronal-Excitatory-eN1(Slc17a7)-eN1_2-Pvrl3\|Hippocampus / BrainAtlas - Mouse McCarroll V32	CATSPERZ CCBE1 SLC38A4 KDM7A	1.37e-05	127	51	4	9bc55cb9f4bddb274930784d12a83b9dceb35cb7
Disease	syndromic X-linked intellectual disability (implicated_via_orthology)	ATP6AP2 KDM7A	7.21e-05	8	48	2	DOID:0060309 (implicated_via_orthology)
Disease	testosterone measurement	LIMA1 MYO5A ZC3H4 SLC38A4 PRKCA LEF1 BIRC6 OPHN1	9.61e-04	1275	48	8	EFO_0004908
Disease	ovarian cancer (is_implicated_in)	PRKCA LEF1	3.77e-03	56	48	2	DOID:2394 (is_implicated_in)
Disease	aggressive behaviour measurement, ADHD symptom measurement	KDM7A BIRC6	5.51e-03	68	48	2	EFO_0007826, EFO_0007860
Disease	unipolar depression, alcohol dependence	NLN IGSF9B	7.19e-03	78	48	2	EFO_0003761, MONDO_0007079

Protein segments in the cluster

Peptide	Gene	Start	Entry
PKGHEDDSYEARKSF	ADNP	756	Q9H2P0
GSLDEGYKASHKPEE	CATSPERZ	71	Q9NTU4
GYKASHKPEELDEHA	CATSPERZ	76	Q9NTU4
KHSHPSDEKDFSFPR	SLC4A2	426	P04920
TDSYKRLHPEKDHGD	BIRC6	4021	Q9NR09
SADHSRLPEAKKYLH	ARL9	96	Q6T311
EHPKEGPYVEDLSKH	KIF16B	176	Q96L93
HHKEGDADSFSKVRP	OPHN1	716	O60890
EPYHDKAREHPDDGK	LEF1	81	Q9UJU2
YHPDKHRDPELKSQA	DNAJC11	41	Q9NVH1
HRHDYTEIDDGSKPV	KDM7A	101	Q6ZMT4
KALHDEGADRKYTSP	HOXA6	121	P31267
LGTKPKDSVYIHDHE	MAPKAPK5	366	Q8IW41
RYPHIKDGEDLKDHS	LIMA1	141	Q9UHB6
RHGGYKPSDEHKTDL	CKB	96	P12277
HRKEHYLSGAQEPDS	PLXNA3	136	P51805
YDLAASEPKKHELSD	PDZD4	441	Q76G19
HYRHSPDTAEGQLKE	RICTOR	261	Q6R327
PSRDRKPHDHKATYD	RBBP6	1536	Q7Z6E9
LSYTEDDKKASPEHR	ORC1	301	Q13415
KHLAKDHSPDLYSLE	ATP6AP2	201	O75787
RGDKYPNDTGHEKSE	CCBE1	176	Q6UXH8
SKLYSLDHGHEKPQD	BTBD7	41	Q9P203
DRKEAIHELKYSPDG	EML5	406	Q05BV3
KHLDTHSEEPAYRCD	HINFP	301	Q9BQA5
KLGEAEYPHHRAKEQ	JADE3	371	Q92613
HSKGELSEDRHKQYE	UPF2	386	Q9HAU5
KGDKPVTYEEAHAPH	MRPS24	46	Q96EL2
KKHLRDFGEEHPFYD	UTP25	21	Q68CQ4
DDPRSKHKFKIHTYG	PRKCA	96	P17252
KREKLEDHKEHGPQY	SIPA1L3	531	O60292
IKLHPESKDDKHGSY	TCP1	531	P17987
DQEHGRKAHKISYPS	SEMG2	276	Q02383
SPGYHESDSKKSEDL	TICAM2	26	Q86XR7
KKLADYADEHHPGTT	SLC38A4	61	Q969I6
PHADLFRKHEIDGKA	SCMH1	611	Q96GD3
SKHYKDGSPIADDLL	NLN	546	Q9BYT8
LAKHQRSHTGEKPYE	ZNF33B	736	Q06732
NLTEHEKIHTGEKPY	ZNF568	516	Q3ZCX4
HVDPEYAGRASLHDK	IGSF9B	81	Q9UPX0
HERTHTGEKPYKCEE	ZNF682	331	O95780
ELYKHKPHDVISHED	NUP188	476	Q5SRE5
HHEAAPGKASYKDVL	SLAMF8	221	Q9P0V8
HERTHTGEKPYECKE	ZNF709	186	Q8N972
DDSDFSPSEKGHRKY	ZC3H4	141	Q9UPT8
YRSRDHDKPHQQSDK	ZC3H4	376	Q9UPT8
DDHGYDAVARKATKP	ZHX2	701	Q9Y6X8
LIAHEKIHSGEKPYE	ZNF569	481	Q5MCW4
HKRIHTGENPYKFEE	ZNF355P	146	Q9NSJ1
HERTHTGEKPYECKE	ZNF44	626	P15621
SKARGDFLPQHEHKD	ZFYVE16	391	Q7Z3T8
HERTHTGEKPYECKE	ZNF669	296	Q96BR6
HLEEGKDLEYHLDPK	MYO5A	41	Q9Y4I1