Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	calcium ion binding	SNED1 FBLN1 THBD HMCN1 CD248 FAT3 LRP2 LTBP3 EGFL8 CLSTN1 ZZEF1 ITGB1 FBN3 CRB2 PROC	1.81e-09	749	57	15	GO:0005509
GeneOntologyCellularComponent	external encapsulating structure	SNED1 FBLN1 HMCN1 CD248 LTBP3 MUC2 ITGB1 PKHD1L1 FBN3	6.69e-05	658	57	9	GO:0030312
GeneOntologyCellularComponent	perikaryon	KCNA2 CSF1R KCNB1 CACNA1H CTNND2	3.52e-04	223	57	5	GO:0043204
GeneOntologyCellularComponent	extracellular matrix	SNED1 FBLN1 HMCN1 CD248 LTBP3 MUC2 ITGB1 FBN3	3.83e-04	656	57	8	GO:0031012
GeneOntologyCellularComponent	dendrite	KCNA2 KCNB1 SYNE1 FAT3 LRP2 CACNA1H CTNND2 CLSTN1 ITGB1	4.86e-04	858	57	9	GO:0030425
GeneOntologyCellularComponent	dendritic tree	KCNA2 KCNB1 SYNE1 FAT3 LRP2 CACNA1H CTNND2 CLSTN1 ITGB1	4.94e-04	860	57	9	GO:0097447
GeneOntologyCellularComponent	cell surface	THBD SLAMF6 CSF1R KCNB1 CD248 LRP2 EGFL8 CLSTN1 ZZEF1 ITGB1	7.61e-04	1111	57	10	GO:0009986
GeneOntologyCellularComponent	postsynaptic membrane	KCNA2 KCNB1 SYNE1 CACNA1H CLSTN1 ITGB1	8.03e-04	405	57	6	GO:0045211
MousePheno	abnormal viscerocranium morphology	FBLN1 CSF1R APAF1 LRP2 PKDCC ZNF521 SALL4 LTBP3 ZZEF1 ITGB1	2.19e-05	593	47	10	MP:0005274
MousePheno	abnormal nose morphology	FBLN1 APAF1 LRP2 PKDCC SALL4 LTBP3	5.39e-05	201	47	6	MP:0002233
MousePheno	abnormal coping response	CSF1R AFM ZNF521 ZZEF1	6.94e-05	66	47	4	MP:0003062
MousePheno	abnormal heart layer morphology	FBLN1 THBD ASXL3 LRP2 SALL4 CACNA1H PPARA UVRAG	7.22e-05	422	47	8	MP:0010545
MousePheno	abnormal lung thrombosis	THBD PROC	1.10e-04	5	47	2	MP:0031167
Domain	EGF_Ca-bd_CS	SNED1 FBLN1 THBD HMCN1 CD248 FAT3 LRP2 LTBP3 EGFL8 FBN3 CRB2 PROC	1.11e-16	97	57	12	IPR018097
Domain	EGF_CA	SNED1 FBLN1 THBD HMCN1 CD248 FAT3 LRP2 LTBP3 EGFL8 FBN3 CRB2 PROC	1.44e-16	99	57	12	PS01187
Domain	EGF-type_Asp/Asn_hydroxyl_site	SNED1 FBLN1 THBD HMCN1 CD248 FAT3 LRP2 LTBP3 EGFL8 FBN3 CRB2 PROC	3.37e-16	106	57	12	IPR000152
Domain	EGF_CA	SNED1 FBLN1 THBD HMCN1 CD248 FAT3 LRP2 LTBP3 EGFL8 FBN3 CRB2 PROC	1.92e-15	122	57	12	SM00179
Domain	EGF-like_Ca-bd_dom	SNED1 FBLN1 THBD HMCN1 CD248 FAT3 LRP2 LTBP3 EGFL8 FBN3 CRB2 PROC	2.34e-15	124	57	12	IPR001881
Domain	ASX_HYDROXYL	SNED1 FBLN1 THBD HMCN1 FAT3 LRP2 LTBP3 EGFL8 FBN3 CRB2 PROC	8.87e-15	100	57	11	PS00010
Domain	EGF_1	SNED1 FBLN1 THBD HMCN1 CD248 FAT3 LRP2 LTBP3 EGFL8 ITGB1 FBN3 CRB2 PROC	6.06e-13	255	57	13	PS00022
Domain	EGF-like_CS	SNED1 FBLN1 THBD HMCN1 CD248 FAT3 LRP2 LTBP3 EGFL8 ITGB1 FBN3 CRB2 PROC	8.15e-13	261	57	13	IPR013032
Domain	EGF_CA	FBLN1 THBD HMCN1 CD248 FAT3 LRP2 LTBP3 EGFL8 FBN3	4.55e-12	86	57	9	PF07645
Domain	EGF_3	SNED1 FBLN1 THBD HMCN1 CD248 FAT3 LRP2 LTBP3 EGFL8 FBN3 CRB2 PROC	5.10e-12	235	57	12	PS50026
Domain	EGF	SNED1 FBLN1 THBD HMCN1 CD248 FAT3 LRP2 LTBP3 EGFL8 FBN3 CRB2 PROC	5.10e-12	235	57	12	SM00181
Domain	EGF-like_dom	SNED1 FBLN1 THBD HMCN1 CD248 FAT3 LRP2 LTBP3 EGFL8 FBN3 CRB2 PROC	1.01e-11	249	57	12	IPR000742
Domain	EGF_2	SNED1 FBLN1 THBD HMCN1 CD248 FAT3 LRP2 LTBP3 EGFL8 FBN3 CRB2 PROC	2.08e-11	265	57	12	PS01186
Domain	cEGF	FBLN1 THBD HMCN1 LRP2 LTBP3 FBN3	1.35e-10	26	57	6	IPR026823
Domain	cEGF	FBLN1 THBD HMCN1 LRP2 LTBP3 FBN3	1.35e-10	26	57	6	PF12662
Domain	EGF	SNED1 THBD HMCN1 CD248 LRP2 EGFL8 FBN3 CRB2 PROC	1.48e-10	126	57	9	PF00008
Domain	Growth_fac_rcpt_	FBLN1 THBD HMCN1 CD248 LRP2 LTBP3 FBN3	4.62e-07	156	57	7	IPR009030
Domain	hEGF	SNED1 LTBP3 FBN3 CRB2	1.51e-06	28	57	4	PF12661
Domain	TB	LTBP3 FBN3	1.90e-04	7	57	2	PF00683
Domain	-	LTBP3 FBN3	2.53e-04	8	57	2	3.90.290.10
Domain	TB	LTBP3 FBN3	3.25e-04	9	57	2	PS51364
Domain	TB_dom	LTBP3 FBN3	3.25e-04	9	57	2	IPR017878
Domain	ConA-like_dom	FAT3 TRIM41 HERC1 CLSTN1 CRB2	5.40e-04	219	57	5	IPR013320
Domain	BTB_2	KCNA2 KCNB1 KCTD20	5.67e-04	53	57	3	PF02214
Domain	T1-type_BTB	KCNA2 KCNB1 KCTD20	5.67e-04	53	57	3	IPR003131
Domain	Channel_four-helix_dom	KCNA2 KCNB1 CACNA1H	7.02e-04	57	57	3	IPR027359
Domain	-	KCNA2 KCNB1 CACNA1H	7.02e-04	57	57	3	1.20.120.350
Domain	TIL_dom	LRP2 MUC2	8.13e-04	14	57	2	IPR002919
Domain	-	FAT3 CLSTN1 CRB2	3.06e-03	95	57	3	2.60.120.200
Domain	IPT	PKHD1L1 PLXNA1	3.06e-03	27	57	2	SM00429
Domain	K_chnl_volt-dep_Kv	KCNA2 KCNB1	3.06e-03	27	57	2	IPR003968
Domain	-	APAF1 NUP133 HERC1 WDFY2 PLXNA1	3.43e-03	333	57	5	2.130.10.10
Domain	WD40/YVTN_repeat-like_dom	APAF1 NUP133 HERC1 WDFY2 PLXNA1	3.52e-03	335	57	5	IPR015943
Domain	TIG	PKHD1L1 PLXNA1	4.02e-03	31	57	2	PF01833
Domain	IPT	PKHD1L1 PLXNA1	4.28e-03	32	57	2	IPR002909
Domain	VG_K_chnl	KCNA2 KCNB1	4.55e-03	33	57	2	IPR028325
Domain	Ion_trans_dom	KCNA2 KCNB1 CACNA1H	5.10e-03	114	57	3	IPR005821
Domain	Ion_trans	KCNA2 KCNB1 CACNA1H	5.10e-03	114	57	3	PF00520
Domain	LAM_G_DOMAIN	FAT3 CRB2	6.00e-03	38	57	2	PS50025
Pathway	REACTOME_MOLECULES_ASSOCIATED_WITH_ELASTIC_FIBRES	FBLN1 LTBP3 ITGB1 FBN3	5.06e-06	37	44	4	M27134
Pathway	REACTOME_ELASTIC_FIBRE_FORMATION	FBLN1 LTBP3 ITGB1 FBN3	1.02e-05	44	44	4	M26969
Pathway	BIOCARTA_TFF_PATHWAY	APAF1 MUC2 ITGB1	5.49e-05	24	44	3	M15926
Pathway	BIOCARTA_TFF_PATHWAY	APAF1 MUC2 ITGB1	9.80e-05	29	44	3	MM1522
Pubmed	Fibulin, a novel protein that interacts with the fibronectin receptor beta subunit cytoplasmic domain.	FBLN1 ITGB1	2.64e-06	2	57	2	2527614
Pubmed	Upregulation of APAF1 and CSF1R in Peripheral Blood Mononuclear Cells of Parkinson's Disease.	CSF1R APAF1	2.64e-06	2	57	2	37108258
Pubmed	Quantitative analysis of thrombomodulin-mediated conversion of protein C to APC: translation from in vitro to in vivo.	THBD PROC	2.64e-06	2	57	2	22750541
Pubmed	Thrombomodulin-mediated catabolism of protein C by pleural mesothelial and vascular endothelial cells.	THBD PROC	2.64e-06	2	57	2	17849052
Pubmed	A thrombomodulin mutation that impairs activated protein C generation results in uncontrolled lung inflammation during murine tuberculosis.	THBD PROC	2.64e-06	2	57	2	16014564
Pubmed	Modeling zymogen protein C.	THBD PROC	2.64e-06	2	57	2	11106601
Pubmed	Age-dependent vulnerability to endotoxemia is associated with reduction of anticoagulant factors activated protein C and thrombomodulin.	THBD PROC	2.64e-06	2	57	2	20348393
Pubmed	The effects of thrombomodulin and activated protein C on the pathogenesis of multiple sclerosis.	THBD PROC	2.64e-06	2	57	2	27456888
Pubmed	Levels of protein C and soluble thrombomodulin in critically ill patients with acute kidney injury: a multicenter prospective observational study.	THBD PROC	2.64e-06	2	57	2	25790110
Pubmed	A novel intracellular fibulin-1D variant binds to the cytoplasmic domain of integrin beta 1 subunit.	FBLN1 ITGB1	2.64e-06	2	57	2	25661773
Pubmed	Activated protein C protects against diabetic nephropathy by inhibiting endothelial and podocyte apoptosis.	THBD PROC	2.64e-06	2	57	2	17982464
Pubmed	Activation of protein C by the thrombin-thrombomodulin complex: cooperative roles of Arg-35 of thrombin and Arg-67 of protein C.	THBD PROC	7.91e-06	3	57	2	16418283
Pubmed	Fibulin-1 suppression of fibronectin-regulated cell adhesion and motility.	FBLN1 ITGB1	7.91e-06	3	57	2	11792823
Pubmed	Mutations in autolytic loop-2 and at Asp554 of human prothrombin that enhance protein C activation by meizothrombin.	THBD PROC	7.91e-06	3	57	2	12588872
Pubmed	Activated protein C ameliorates diabetic nephropathy by epigenetically inhibiting the redox enzyme p66Shc.	THBD PROC	7.91e-06	3	57	2	23267072
Pubmed	Gemfibrozil and fenofibrate, Food and Drug Administration-approved lipid-lowering drugs, up-regulate tripeptidyl-peptidase 1 in brain cells via peroxisome proliferator-activated receptor α: implications for late infantile Batten disease therapy.	TPP1 PPARA	7.91e-06	3	57	2	22989886
Pubmed	Treadmill exercise reduces α-synuclein spreading via PPARα.	TPP1 PPARA	7.91e-06	3	57	2	35830804
Pubmed	Thrombomodulin-protein C-EPCR system: integrated to regulate coagulation and inflammation.	THBD PROC	7.91e-06	3	57	2	15178554
Pubmed	The affinity of protein C for the thrombin.thrombomodulin complex is determined in a primary way by active site-dependent interactions.	THBD PROC	7.91e-06	3	57	2	15705565
Pubmed	Megalin/LRP2 expression is induced by peroxisome proliferator-activated receptor -alpha and -gamma: implications for PPARs' roles in renal function.	LRP2 PPARA	7.91e-06	3	57	2	21311715
Pubmed	Thrombomodulin changes the molecular surface of interaction and the rate of complex formation between thrombin and protein C.	THBD PROC	7.91e-06	3	57	2	15582990
Pubmed	Antithrombin-resistant prothrombin Yukuhashi mutation also causes thrombomodulin resistance in fibrinogen clotting but not in protein C activation.	THBD PROC	7.91e-06	3	57	2	25149909
Pubmed	The Sal-like 4 - integrin α6β1 network promotes cell migration for metastasis via activation of focal adhesion dynamics in basal-like breast cancer cells.	SALL4 ITGB1	7.91e-06	3	57	2	27773610
Pubmed	Latent transforming growth factor beta-binding protein-3 and fibulin-1C interact with the extracellular domain of the heparin-binding EGF-like growth factor precursor.	FBLN1 LTBP3	7.91e-06	3	57	2	11846885
Pubmed	Platelet factor 4 binds to glycanated forms of thrombomodulin and to protein C. A potential mechanism for enhancing generation of activated protein C.	THBD PROC	7.91e-06	3	57	2	9395524
Pubmed	How Thrombomodulin Enables W215A/E217A Thrombin to Cleave Protein C but Not Fibrinogen.	THBD PROC	7.91e-06	3	57	2	34978431
Pubmed	Kv2.1 and electrically silent Kv6.1 potassium channel subunits combine and express a novel current.	KCNA2 KCNB1	7.91e-06	3	57	2	8980147
Pubmed	Macromolecular specificity determinants on thrombin for fibrinogen and thrombomodulin.	THBD PROC	7.91e-06	3	57	2	2544585
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	NFX1 CACNA1H LTBP3 PPARA HERC1 ZZEF1 UVRAG PLXNA1 NBPF1 MYBL2	1.12e-05	1105	57	10	35748872
Pubmed	The roles of protein C and thrombomodulin in the regulation of blood coagulation.	THBD PROC	1.58e-05	4	57	2	2538457
Pubmed	The thrombomodulin-protein C system is essential for the maintenance of pregnancy.	THBD PROC	1.58e-05	4	57	2	12579195
Pubmed	Modulation of thrombomodulin-dependent activation of human protein C through differential expression of endothelial Smads.	THBD PROC	1.58e-05	4	57	2	12407115
Pubmed	Biochemical characterization of the native Kv2.1 potassium channel.	KCNA2 KCNB1	1.58e-05	4	57	2	16008572
Pubmed	Combined effects of thrombosis pathway gene variants predict cardiovascular events.	THBD PROC	1.58e-05	4	57	2	17677000
Pubmed	Polymorphisms in antithrombin and in tissue factor pathway inhibitor genes are associated with recurrent pregnancy loss.	THBD PROC	1.58e-05	4	57	2	22918506
Pubmed	The cytoplasmic tail of fibrocystin contains a ciliary targeting sequence.	LRP2 PKHD1L1	2.63e-05	5	57	2	20048263
Pubmed	K+ current diversity is produced by an extended gene family conserved in Drosophila and mouse.	KCNA2 KCNB1	2.63e-05	5	57	2	2333511
Pubmed	Ion channel expression in the developing enteric nervous system.	KCNA2 KCNB1 CACNA1H	3.12e-05	37	57	3	25798587
Pubmed	Increased tissue factor-initiated prothrombin activation as a result of the Arg506 --> Gln mutation in factor VLEIDEN.	THBD PROC	3.94e-05	6	57	2	9252393
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	PLEKHH1 TPP1 SYNE1 CEP57L1 LRP2 ZNF521 HLCS LTBP3 CTNND2 LRRFIP1	4.06e-05	1285	57	10	35914814
Pubmed	Low-density lipoprotein receptor-related protein (LRP)-2/megalin is transiently expressed in a subpopulation of neural progenitors in the embryonic mouse spinal cord.	TUBB1 LRP2	5.51e-05	7	57	2	16196028
Pubmed	The primitive endoderm segregates from the epiblast in β1 integrin-deficient early mouse embryos.	LRP2 ITGB1	5.51e-05	7	57	2	24277939
Pubmed	PAR1 signaling regulates the retention and recruitment of EPCR-expressing bone marrow hematopoietic stem cells.	THBD PROC	5.51e-05	7	57	2	26457757
Pubmed	Arf4 is required for Mammalian development but dispensable for ciliary assembly.	LRP2 PKHD1L1	5.51e-05	7	57	2	24586199
Pubmed	Signal integration at the PI3K-p85-XBP1 hub endows coagulation protease activated protein C with insulin-like function.	THBD PROC	5.51e-05	7	57	2	28687614
Pubmed	Replication of findings on the association of genetic variation in 24 hemostasis genes and risk of incident venous thrombosis.	THBD PROC	5.51e-05	7	57	2	19682239
Pubmed	Heteromultimeric delayed-rectifier K+ channels in schwann cells: developmental expression and role in cell proliferation.	KCNA2 KCNB1	5.51e-05	7	57	2	9852577
Pubmed	In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.	TUBB1 FBLN1 HMCN1 CD248 AFM TPP1 LRP2 ITGB1 CRB2	5.70e-05	1070	57	9	23533145
Pubmed	Endothelial protein C receptor-expressing hematopoietic stem cells reside in the perisinusoidal niche in fetal liver.	THBD PROC	9.43e-05	9	57	2	20442369
Pubmed	Disrupted in Schizophrenia 1 Interactome: evidence for the close connectivity of risk genes and a potential synaptic basis for schizophrenia.	GSE1 SYNE1 CEP57L1 WWC1	1.13e-04	151	57	4	17043677
Pubmed	Developmental expression of voltage-sensitive K+ channels in mouse skeletal muscle and C2C12 cells.	KCNA2 KCNB1	1.18e-04	10	57	2	1383027
Pubmed	Two dominant host resistance genes to pre-B lymphoma in wild-derived inbred mouse strain MSM/Ms.	CSF1R ZNF521	1.18e-04	10	57	2	8706013
Pubmed	Gene variants associated with venous thrombosis: confirmation in the MEGA study.	THBD PROC	1.72e-04	12	57	2	20128871
Pubmed	Overexpression of Flii during Murine Embryonic Development Increases Symmetrical Division of Epidermal Progenitor Cells.	ITGB1 LRRFIP1	2.37e-04	14	57	2	34361001
Pubmed	Kelch Domain of Gigaxonin Interacts with Intermediate Filament Proteins Affected in Giant Axonal Neuropathy.	SYNE1 CACNA1H ZZEF1 PLXNA1	2.56e-04	187	57	4	26460568
Pubmed	Proteome-wide characterization of N-glycosylation events by diagonal chromatography.	CSF1R AFM PROC	2.80e-04	77	57	3	16944957
Pubmed	Application of gene network analysis techniques identifies AXIN1/PDIA2 and endoglin haplotypes associated with bicuspid aortic valve.	FBLN1 CSF1R	3.12e-04	16	57	2	20098615
Pubmed	Alteration of Neuronal Excitability and Short-Term Synaptic Plasticity in the Prefrontal Cortex of a Mouse Model of Mental Illness.	KCNA2 KCNB1	3.12e-04	16	57	2	28283561
Pubmed	Systematic Analysis of Human Protein Phosphatase Interactions and Dynamics.	SYNE1 PPP4R2 HLCS PRR14L HERC1 ITGB1	3.47e-04	573	57	6	28330616
Pubmed	SHH propagates distal limb bud development by enhancing CYP26B1-mediated retinoic acid clearance via AER-FGF signalling.	PKDCC SALL4	3.53e-04	17	57	2	21471156
Pubmed	Kv7/KCNQ potassium channels in cortical hyperexcitability and juvenile seizure-related death in Ank2-mutant mice.	KCNA2 KCNB1	3.97e-04	18	57	2	37321992
Pubmed	Hemidesmosome integrity protects the colon against colitis and colorectal cancer.	MUC2 ITGB1	3.97e-04	18	57	2	27371534
Pubmed	YAP/TAZ-Dependent Reprogramming of Colonic Epithelium Links ECM Remodeling to Tissue Regeneration.	MUC2 ITGB1	3.97e-04	18	57	2	29249464
Pubmed	Genome-wide association study combining pathway analysis for typical sporadic amyotrophic lateral sclerosis in Chinese Han populations.	GSE1 FAT3 CTNND2	4.29e-04	89	57	3	24529757
Pubmed	A dual-strategy expression screen for candidate connectivity labels in the developing thalamus.	FAT3 CLSTN1 PLXNA1	4.58e-04	91	57	3	28558017
Pubmed	Integrative predictive model of coronary artery calcification in atherosclerosis.	THBD HMCN1 CACNA1H PPARA	5.50e-04	229	57	4	19948975
Pubmed	Time-sequenced transcriptomes of developing distal mouse limb buds: A comparative tissue layer analysis.	SALL4 WWC1	5.97e-04	22	57	2	34254395
Pubmed	Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	SYNE1 ASXL3 NBPF1	6.39e-04	102	57	3	11214970
Pubmed	Mammalian APE1 controls miRNA processing and its interactome is linked to cancer RNA metabolism.	GSE1 TPP1 CEP57L1 APAF1 LTBP3 UVRAG WWC1	7.65e-04	925	57	7	28986522
Pubmed	ERp57 is essential for efficient folding of glycoproteins sharing common structural domains.	ITGB1 PLXNA1	7.73e-04	25	57	2	17170699
Pubmed	Gse1, a component of the CoREST complex, is required for placenta development in the mouse.	GSE1 ITGB1	7.73e-04	25	57	2	37019373
Pubmed	Chromosomal mapping in the mouse of eight K(+)-channel genes representing the four Shaker-like subfamilies Shaker, Shab, Shaw, and Shal.	KCNA2 KCNB1	8.36e-04	26	57	2	7905852
Pubmed	Aberrant differentiation of second heart field mesoderm prefigures cellular defects in the outflow tract in response to loss of FGF8.	GSE1 ITGB1	8.36e-04	26	57	2	37060937
Pubmed	Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.	CSF1R AFM ITGB1 PROC	8.46e-04	257	57	4	16335952
Pubmed	Common polymorphisms in ITGA2, PON1 and THBS2 are associated with coronary atherosclerosis in a candidate gene association study of the Chinese Han population.	PPARA ITGB1 PROC	9.05e-04	115	57	3	20485444
Pubmed	The basement membrane of hair follicle stem cells is a muscle cell niche.	FBLN1 ITGB1	9.71e-04	28	57	2	21335239
Pubmed	Muscle developmental defects in heterogeneous nuclear Ribonucleoprotein A1 knockout mice.	RCAN3 LRRFIP1	1.11e-03	30	57	2	28077597
Pubmed	Voltage-gated potassium channel genes are clustered in paralogous regions of the mouse genome.	KCNA2 KCNB1	1.19e-03	31	57	2	8034307
Pubmed	Use of RDA analysis of knockout mice to identify myeloid genes regulated in vivo by PU.1 and C/EBPalpha.	CSF1R PROC	1.27e-03	32	57	2	9611252
Pubmed	Cellular heterogeneity in the ureteric progenitor niche and distinct profiles of branching morphogenesis in organ development.	FBLN1 PKDCC CTNND2	1.29e-03	130	57	3	28705898
Pubmed	A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome.	GSE1 SYNE1 NUP133 PPARA ITGB1	1.33e-03	497	57	5	23414517
Pubmed	Genome wide association study (GWAS) of Chagas cardiomyopathy in Trypanosoma cruzi seropositive subjects.	THBD ASXL3 CTNND2	1.41e-03	134	57	3	24324551
Pubmed	LKB1 deletion causes early changes in atrial channel expression and electrophysiology prior to atrial fibrillation.	KCNB1 CACNA1H	1.43e-03	34	57	2	26378152
Pubmed	Early embryonic expression of murine coagulation system components.	THBD PROC	1.43e-03	34	57	2	11154109
Pubmed	Foxf2 Is Required for Brain Pericyte Differentiation and Development and Maintenance of the Blood-Brain Barrier.	CD248 ITGB1	1.43e-03	34	57	2	26120030
Pubmed	Large-scale analysis of ion channel gene expression in the mouse heart during perinatal development.	KCNA2 KCNB1 CACNA1H	1.56e-03	139	57	3	16985003
Pubmed	Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.	GTF2E1 GSE1 PPP4R2 NUP133 HERC1 ITGB1 RCAN3	1.58e-03	1049	57	7	27880917
Cytoband	20q13.2	KCNB1 SALL4	5.21e-04	27	57	2	20q13.2
Cytoband	22q13.31	FBLN1 PPARA	1.51e-03	46	57	2	22q13.31
Cytoband	Ensembl 112 genes in cytogenetic band chr20q13	TUBB1 KCNB1 SALL4 MYBL2	1.89e-03	422	57	4	chr20q13
Cytoband	2q37.3	SNED1 LRRFIP1	4.17e-03	77	57	2	2q37.3
GeneFamily	Fibulins	FBLN1 HMCN1	1.26e-04	8	39	2	556
GeneFamily	Cadherin related	FAT3 CLSTN1	6.04e-04	17	39	2	24
GeneFamily	ADAM metallopeptidase domain containing\|CD molecules	THBD SLAMF6 CSF1R CD248 ITGB1	1.50e-03	394	39	5	471
GeneFamily	Potassium voltage-gated channels	KCNA2 KCNB1	3.36e-03	40	39	2	274
GeneFamily	Hyalectan proteoglycans\|V-set domain containing\|Sushi domain containing\|C-type lectin domain containing	THBD CD248	3.53e-03	41	39	2	1298
Coexpression	RODRIGUES_THYROID_CARCINOMA_POORLY_DIFFERENTIATED_DN	PLEKHH1 SNED1 FBLN1 MRI1 LTBP3 HERC1 RCAN3 WWC1 LRRFIP1	5.69e-05	807	57	9	M16651
Coexpression	NABA_ECM_GLYCOPROTEINS	SNED1 FBLN1 SLAMF6 HMCN1 LTBP3	6.00e-05	191	57	5	MM17059
Coexpression	GSE34205_HEALTHY_VS_RSV_INF_INFANT_PBMC_UP	SLAMF6 GSE1 SYNE1 LTBP3 CLSTN1	6.46e-05	194	57	5	M5136
Coexpression	NABA_ECM_GLYCOPROTEINS	SNED1 FBLN1 HMCN1 LTBP3 FBN3	6.78e-05	196	57	5	M3008
Coexpression	GSE3982_BASOPHIL_VS_EFF_MEMORY_CD4_TCELL_DN	CD248 SYNE1 CACNA1H PRR14L ITGB1	6.78e-05	196	57	5	M5557
Coexpression	GSE7548_NAIVE_VS_DAY28_PCC_IMMUNIZATION_CD4_TCELL_UP	GTF2E1 CSF1R LRP2 ITGB1 PROC	7.29e-05	199	57	5	M6839
CoexpressionAtlas	dev gonad_e12.5_M_InterstitLeydig_MafB_k-means-cluster#1_top-relative-expression-ranked_1000	FBLN1 THBD HMCN1 CD248 ASXL3 FAT3 ZNF521 CACNA1H	1.67e-06	310	57	8	gudmap_dev gonad_e12.5_M_InterstitLeydig_MafB_k1_1000
CoexpressionAtlas	kidney_adult_RenalCapsule_top-relative-expression-ranked_1000	FBLN1 THBD CSF1R HMCN1 CD248 FAT3 AOX1 LRP2 LTBP3 UVRAG	3.73e-05	778	57	10	gudmap_kidney_adult_RenalCapsule_1000
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HMCN1 ASXL3 FAT3 LRP2 SALL4 PKHD1L1 UNC79	3.80e-09	184	57	7	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HMCN1 ASXL3 FAT3 LRP2 SALL4 PKHD1L1 UNC79	3.80e-09	184	57	7	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HMCN1 ASXL3 FAT3 LRP2 SALL4 PKHD1L1 UNC79	3.80e-09	184	57	7	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	Tracheal-NucSeq-Stromal-Fibroblastic\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	SNED1 FBLN1 HMCN1 SYNE1 AOX1 ZNF521	2.15e-07	200	57	6	b4ccffdd79526c85e5273d27b668dbddcddba1ee
ToppCell	ILEUM-non-inflamed-(3)_pDC\|non-inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	THBD FAT3 CRB2 PROC MYBL2	2.11e-06	163	57	5	bc5411702badab39143905aa51676b4bbfad2041
ToppCell	368C-Fibroblasts-Fibroblast-J_(Lipofibroblast)\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	KCNB1 LRP2 WWC1 CRB2 PROC	2.45e-06	168	57	5	e870d2e69316406f45112ed0bf324b24f902a99e
ToppCell	368C-Fibroblasts-Fibroblast-J_(Lipofibroblast)-\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	KCNB1 LRP2 WWC1 CRB2 PROC	2.45e-06	168	57	5	403aba73a0f9ffb32252288d075fad8a588ca440
ToppCell	3'-Broncho-tracheal-Mesenchymal-Fibroblastic-fibroblastic_type_1-Adventitial_fibroblasts-\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SNED1 FBLN1 CD248 AOX1 PKDCC	2.75e-06	172	57	5	e37c0b5b547a7345179ab258dd2141fec7064c17
ToppCell	Adult-Mesenchymal-matrix_fibroblast_2_cell-D231\|Adult / Lineage, Cell type, age group and donor	SNED1 FBLN1 CD248 AOX1 ZNF521	3.92e-06	185	57	5	fb6bd7e849ecf4ed9cd9c4e2a946a2d12d62f804
ToppCell	pdx-Tumor_cells-T0\|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)	GSE1 AFM AOX1 CACNA1H CTNND2	3.92e-06	185	57	5	1d874608aa2062024323512f68889219471b2f00
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_1_/_Segment_2\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	AFM AOX1 LRP2 PPARA WWC1	4.02e-06	186	57	5	5784d255e9ca449d375d81938d0fbbd8a7eb44f6
ToppCell	LPS-antiTNF-Endothelial-Endothelial-Gen_Cap\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	THBD HMCN1 ZNF521 HLCS CTNND2	4.82e-06	193	57	5	6e1982d089a9de628e6006d23ff78a223fbd9f47
ToppCell	LPS-IL1RA+antiTNF-Stromal_mesenchymal-Matrix_Fibroblast-MatrixFB\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SNED1 FBLN1 ASXL3 FAT3 AOX1	4.82e-06	193	57	5	fb28717fadd06c3840636d25409ce80c9254bd34
ToppCell	LPS-antiTNF-Stromal_mesenchymal-Matrix_Fibroblast-MatrixFB\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SNED1 FBLN1 SYNE1 FAT3 AOX1	4.94e-06	194	57	5	60622bd2f75bfe4c37f721cb12f03dab33f2f58d
ToppCell	LPS-antiTNF-Stromal_mesenchymal-Matrix_Fibroblast-Activated_MatrixFB\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SNED1 FBLN1 ASXL3 FAT3 AOX1	4.94e-06	194	57	5	89b706af2b25991fc2707eb24f49ba6ff3ae01f7
ToppCell	Smart-seq2-spleen_(Smart-seq2)-myeloid-myeloid_granulocytic-neutrophil\|spleen_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	HMCN1 KCNB1 ASXL3 FAT3 AOX1	5.07e-06	195	57	5	d3755929ebbbf5e3afde44281e9056ddb614a291
ToppCell	Smart-seq2-spleen_(Smart-seq2)-myeloid-myeloid_granulocytic\|spleen_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	HMCN1 KCNB1 ASXL3 FAT3 AOX1	5.07e-06	195	57	5	19853c654ac64b3ae3bc99841c6cb29c8aaba85c
ToppCell	(7)_Epithelial-I_(AT1)\|World / Lung cell shreds - cell class (v4) and cell subclass (v4)	PKDCC CTNND2 PLXNA1 FBN3 WWC1	5.19e-06	196	57	5	150554fa06868d29b0608189862eef6505ba757f
ToppCell	Fetal_29-31_weeks-Mesenchymal\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	SNED1 FBLN1 HMCN1 FAT3 ZNF521	5.46e-06	198	57	5	21cf4d81386761d09d0f6829c01c198e5524176d
ToppCell	Mesenchymal\|World / Lineage, Cell type, age group and donor	SNED1 FBLN1 HMCN1 FAT3 ZNF521	5.59e-06	199	57	5	4bac110c2b3609f6ee5d0e3275da0824a6240270
ToppCell	LPS_anti-TNF-Epithelial_alveolar-AT_1-Differentiating_AT1\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	PKDCC SALL4 LTBP3 PLXNA1 WWC1	5.59e-06	199	57	5	d43c605a4ff221cf78d91678c15d2ad20f831c7f
ToppCell	(5)_Fibroblast-D\|World / Lung cell shreds - cell class (v4) and cell subclass (v4)	FBLN1 CD248 AOX1 PKDCC RCAN3	5.59e-06	199	57	5	3f415620ad8b8d8c6871e1353e13f87b281fcc0e
ToppCell	Bronchus_Control_(B.)-Stromal-TX-Fibroblasts-2,_SCARA5\|Bronchus_Control_(B.) / Sample group, Lineage and Cell type	FBLN1 CD248 AOX1 PKDCC ZNF521	5.73e-06	200	57	5	2022df85df94ab8cbb4e80e3fe9894c01051c5e0
ToppCell	Bronchial-NucSeq-Stromal\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	FBLN1 HMCN1 FAT3 AOX1 ZNF521	5.73e-06	200	57	5	389cc775c8419d90fb77cd794376d2160a7bf44e
ToppCell	Bronchus_Control_(B.)-Stromal-TX\|Bronchus_Control_(B.) / Sample group, Lineage and Cell type	FBLN1 CD248 AOX1 PKDCC ZNF521	5.73e-06	200	57	5	69b41f5fb370aa8840a9ad7919d03ef1e57d1b5b
ToppCell	cellseq2-Mesenchymal-Fibroblastic-Fibroblastic_1-AF2\|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	SNED1 FBLN1 HMCN1 CD248 AOX1	5.73e-06	200	57	5	44317fbf4d1480a37b50ab2777bf1a3e4fc0c05f
ToppCell	Bronchial-NucSeq-Stromal-Fibroblastic\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	FBLN1 HMCN1 FAT3 AOX1 ZNF521	5.73e-06	200	57	5	cae972324d1dfea6efeaf6013f265c7c6bb48db4
ToppCell	Tracheal-NucSeq-Stromal\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	SNED1 FBLN1 SYNE1 AOX1 ZNF521	5.73e-06	200	57	5	c318d14bd6fd6f42c597eb55ac9e2f48008aeb9b
ToppCell	cellseq2-Mesenchymal-Fibroblastic\|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	SNED1 FBLN1 HMCN1 CD248 AOX1	5.73e-06	200	57	5	1c10597edd532bf172ca09870a937d35e2585081
ToppCell	cellseq2-Mesenchymal-Fibroblastic-Fibroblastic_1\|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	SNED1 FBLN1 HMCN1 CD248 AOX1	5.73e-06	200	57	5	440dda48b09c6a8581b7ca634b0d67f1ecacf65e
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell-mesangial_atypical\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	KCNA2 KCNB1 CD248 CTNND2	3.88e-05	148	57	4	b7b5521162effc1024e7c399f690cd86d0b2f750
ToppCell	P28-Mesenchymal-mesenchymal_fibroblast-mesenchymal_progenitor_cell\|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	FBLN1 KCNA2 ASXL3 CRB2	4.53e-05	154	57	4	44d4d99b08216c0901e3bc32743fa0a8b85b5149
ToppCell	PND07-28-samps-Mesenchymal-Mesothelial\|PND07-28-samps / Age Group, Lineage, Cell class and subclass	TUBB1 LRP2 PKHD1L1 CRB2	4.76e-05	156	57	4	574f761962a7dd3308bd41fc529dd3ea1b8625f8
ToppCell	PND07-28-samps-Mesenchymal-Mesothelial-Mesothelial\|PND07-28-samps / Age Group, Lineage, Cell class and subclass	TUBB1 LRP2 PKHD1L1 CRB2	4.76e-05	156	57	4	605d95a900e1443d3f6aae163ef2e893d3293203
ToppCell	severe_COVID-19-pDC\|World / disease group, cell group and cell class (v2)	KCNB1 ZNF521 PLXNA1 PROC	5.13e-05	159	57	4	e1c48c4ceda116826819ff9adeed7bad6a58844d
ToppCell	severe_COVID-19-pDC\|severe_COVID-19 / disease group, cell group and cell class (v2)	KCNB1 ZNF521 PLXNA1 PROC	5.13e-05	159	57	4	ea5088d27e42b8850455764d53b757ea8d8f14bc
ToppCell	facs-Marrow-B-cells-24m-Lymphocytic-precursor_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HMCN1 FAT3 LRP2 PKHD1L1	5.25e-05	160	57	4	c381ec6be8cf887861cc18f831a20db42f953fe1
ToppCell	Mild-Lymphoid-Plasma\|Mild / Condition, Lineage, Cell class and cell subclass	FBLN1 ZNF521 PKHD1L1 MYBL2	5.25e-05	160	57	4	7fdb849f5caf5a127a2582326215e11f8eb4fa0e
ToppCell	Mild-Lymphoid-Plasma-\|Mild / Condition, Lineage, Cell class and cell subclass	FBLN1 ZNF521 PKHD1L1 MYBL2	5.25e-05	160	57	4	aa79848913910c01249d6cacf4ed53ec0e4f5c3d
ToppCell	facs-Marrow-B-cells-24m-Lymphocytic-pre_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HMCN1 FAT3 LRP2 PKHD1L1	5.25e-05	160	57	4	25c8f3d2a6d14ff0ca0b965fce89d3ff22f40585
ToppCell	facs-Pancreas-Exocrine-18m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KCNA2 PKDCC HLCS EGFL8	5.65e-05	163	57	4	132aece9c79499b4bb3c2bde68d3d7202e1d8772
ToppCell	Adult-Mesenchymal-chondrocyte-D231\|Adult / Lineage, Cell type, age group and donor	SNED1 FBLN1 HMCN1 SALL4	5.78e-05	164	57	4	2ba57dce5f69a88f0d1e450b9780425e2d9ca7d4
ToppCell	3'_v3-lymph-node_spleen-Hematopoietic_progenitors-Progenitor\|lymph-node_spleen / Manually curated celltypes from each tissue	ASXL3 FAT3 ZNF521 SALL4	6.20e-05	167	57	4	cb396f3edb9e8fdc316091e8e193dbba50e0be0c
ToppCell	3'-GW_trimst-1.5-LargeIntestine-Mesenchymal-mesothelial_cell\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	AOX1 LRP2 PKHD1L1 CRB2	6.50e-05	169	57	4	0cece9b2bb1f58e465c20ec8735a4fc3c1021f03
ToppCell	3'-GW_trimst-1.5-LargeIntestine-Mesenchymal-mesothelial_cell-Mesothelium\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	AOX1 LRP2 PKHD1L1 CRB2	6.50e-05	169	57	4	6937c46b119d4ce382fc8c2fa5925ede5ae89c81
ToppCell	facs-Diaphragm-Limb_Muscle-24m\|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FAT3 LRP2 PKHD1L1 UNC79	6.50e-05	169	57	4	12bdc709bc000d7f9061ecd9fbd57233eaacb7e2
ToppCell	droplet-Marrow-nan-18m-Lymphocytic-plasma_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KCNA2 CSF1R PKDCC PLXNA1	6.65e-05	170	57	4	067657ca7fcf5a0ffbd168b5c4609a30ca508f22
ToppCell	mild_COVID-19-pDC\|World / disease group, cell group and cell class (v2)	HMCN1 ZNF521 PROC MYBL2	6.96e-05	172	57	4	dab2f1a05c7df58d9387b13271b3f1f1583f9ac3
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_1_/_Segment_2\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	AFM LRP2 PPARA UNC79	7.11e-05	173	57	4	8888434641ea554a9b62c436e87920378eef29cd
ToppCell	droplet-Marrow-nan-18m-Myeloid-basophil\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CSF1R ZNF521 ZZEF1 WDFY2	7.27e-05	174	57	4	55cc8300489d11322724159ec7d0e1d32a702e91
ToppCell	COVID-19-lung-RBC\|COVID-19 / Disease (COVID-19 only), tissue and cell type	TUBB1 HERC1 PKHD1L1 MYBL2	7.44e-05	175	57	4	4c35292ad2ac712ba7516f27dd6eac6ba8fdd163
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_3\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	AFM AOX1 LRP2 PPARA	7.77e-05	177	57	4	2f81b26be89cc2fd8eafadaf7eae3c6ad6521462
ToppCell	metastatic_Brain-B_lymphocytes-GrB-secreting_B_cells\|B_lymphocytes / Location, Cell class and cell subclass	THBD MRI1 PROC MYBL2	7.77e-05	177	57	4	43e1d0d3cf8f0c02e67d91f8dd1761df23d59e07
ToppCell	5'-Adult-LargeIntestine-Endothelial-lymphatic_endothelial-LEC1_(ACKR4+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	THBD ZNF521 PKHD1L1 FBN3	7.77e-05	177	57	4	b1775e05c28883a15c56628028770bc59d3233fb
ToppCell	COVID-19-kidney-PCT-S1/S2\|COVID-19 / Disease (COVID-19 only), tissue and cell type	AFM AOX1 LRP2 PPARA	7.94e-05	178	57	4	23a12d3d971b857d5be8e907334d1f6b49eeeb32
ToppCell	3'-GW_trimst-2-SmallIntestine-Mesenchymal-mesothelial_cell\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	AOX1 LRP2 PKHD1L1 CRB2	8.12e-05	179	57	4	056df2aaff750e0e283e7da78fcc3c90c366aac0
ToppCell	3'-GW_trimst-2-SmallIntestine-Mesenchymal-mesothelial_cell-Mesothelium\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	AOX1 LRP2 PKHD1L1 CRB2	8.12e-05	179	57	4	f5f3945ef3b9efc5921a71fd51deeb2c80f0ce11
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_1_/_Segment_2\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	AFM LRP2 PPARA UNC79	8.29e-05	180	57	4	1363b3254470f6ff98630d1df83a1bdbacc137e0
ToppCell	COVID-19-kidney-tDL\|COVID-19 / Disease (COVID-19 only), tissue and cell type	AOX1 LRP2 PPARA WWC1	8.29e-05	180	57	4	864c895b5eaedefae86f5829fa344f7b686fb59f
ToppCell	5'-Adult-LargeIntestine-Mesenchymal-mesothelial_cell\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	KCNB1 LRP2 PKHD1L1 CRB2	8.47e-05	181	57	4	65eaa9bc1022bcf0c5f0f92c07a2cbbf11f9b59c
ToppCell	PND28-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial-Mesothelial_mature\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	LRP2 ZNF521 PKHD1L1 CRB2	8.47e-05	181	57	4	330d4322f4c4373f706273c1f4e218b59051b7fd
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD\|renal_cortex_nuclei / Celltypes from Cells and Nuclei per compartment and clinical group	GSE1 AFM FAT3 LRP2	8.47e-05	181	57	4	c80ffa2ded5975a88e9a1a7d333196f95237bf0a
ToppCell	metastatic_Brain-Fibroblasts-Myofibroblasts\|metastatic_Brain / Location, Cell class and cell subclass	FBLN1 HMCN1 FAT3 ZNF521	8.47e-05	181	57	4	bd0b5f74f9c81ec0f1592710774a4fdf33d9d5a9
ToppCell	5'-Adult-LargeIntestine-Mesenchymal-mesothelial_cell-Mesothelium_(PRG4+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	KCNB1 LRP2 PKHD1L1 CRB2	8.47e-05	181	57	4	eaac7d58117eddfff06b25521efc431c1351d592
ToppCell	PND28-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	LRP2 ZNF521 PKHD1L1 CRB2	8.47e-05	181	57	4	3f4d5d79c1286614514b0e8134079d6128a2a23e
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	FBLN1 KCNB1 CD248 FAT3	8.66e-05	182	57	4	b7d532feb73167e05475855061b35a209583f44c
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	FBLN1 KCNB1 CD248 FAT3	8.66e-05	182	57	4	af65f0fc3f9e5d9ce69ee5faaf5b6cb7f8412e0c
ToppCell	COVID-19-kidney-PCT-S1\|COVID-19 / Disease (COVID-19 only), tissue and cell type	AOX1 LRP2 WWC1 PROC	8.84e-05	183	57	4	6878d14026c3df6aa12e45dfad94b32fa9d9b0b7
ToppCell	5'-GW_trimst-2-LargeIntestine-Mesenchymal-mesothelial_cell-Mesothelium\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	AOX1 LRP2 PKHD1L1 CRB2	8.84e-05	183	57	4	9d5a363fbe6f0a1668c9d584df65ee1c283349c7
ToppCell	5'-GW_trimst-2-LargeIntestine-Mesenchymal-mesothelial_cell\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	AOX1 LRP2 PKHD1L1 CRB2	8.84e-05	183	57	4	c5caac6ed6c8d67f5c336281d9fd903976509445
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_3\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	AOX1 LRP2 PPARA PROC	8.84e-05	183	57	4	85446581999cd66b171c4f69b7eb8b0bbbaa8617
ToppCell	facs-Liver-Non-hepatocytes-24m-Endothelial-nan\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FBLN1 CD248 PKHD1L1 CRB2	8.84e-05	183	57	4	ebe369dc80c4fbf8f4dbe947147f8c47507ffb60
ToppCell	COVID-19-kidney-PCT-S1\|kidney / Disease (COVID-19 only), tissue and cell type	AOX1 LRP2 WWC1 PROC	9.03e-05	184	57	4	51ed1ebfdef45149541917c66cbacad87072e51f
ToppCell	343B-Epithelial_cells-Epithelial-I_(AT1)\|343B / Donor, Lineage, Cell class and subclass (all cells)	PKDCC PLXNA1 FBN3 WWC1	9.03e-05	184	57	4	cb15d6bae52c5ec251c2235859dc7e65f630ae23
ToppCell	Adult-Mesenchymal-matrix_fibroblast_2_cell-D122\|Adult / Lineage, Cell type, age group and donor	FBLN1 CD248 AOX1 ZNF521	9.03e-05	184	57	4	2b7e6f91e11c228f0521e099886867d9e998e78d
ToppCell	COVID-19-kidney-PCT-S1/S2\|kidney / Disease (COVID-19 only), tissue and cell type	AFM AOX1 LRP2 PPARA	9.03e-05	184	57	4	dc71f22583fc54b89b242cbb602f4bbe86f576ec
ToppCell	343B-Epithelial_cells-Epithelial-I_(AT1)-\|343B / Donor, Lineage, Cell class and subclass (all cells)	PKDCC PLXNA1 FBN3 WWC1	9.03e-05	184	57	4	bde4eaabd3e9bdaed23867d23a919b9d84b52d4b
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_3\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	AOX1 LRP2 PPARA PROC	9.03e-05	184	57	4	9434731f651820b05335085582960f08fbf895de
ToppCell	droplet-Lung-21m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l17\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	FBLN1 CD248 CACNA1H LTBP3	9.22e-05	185	57	4	1b990e3089772be2b38c6d7ea0d1bf22461ae3ea
ToppCell	facs-Skin-nan-24m-Mesenchymal\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CD248 FAT3 PKDCC ZNF521	9.22e-05	185	57	4	8433a337625ff8398520e223ef92bf9bb0beb14c
ToppCell	facs-Skin-nan-24m-Mesenchymal-fibroblast\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CD248 FAT3 PKDCC ZNF521	9.22e-05	185	57	4	049d793d043d5d434f143025de49dd210d18756c
ToppCell	Control-Epithelial-Mesothelial\|Epithelial / Disease state, Lineage and Cell class	FBLN1 AOX1 PKHD1L1 CRB2	9.22e-05	185	57	4	0af540323c0113203ba6c1a4cb32d2fb9cf79d39
ToppCell	facs-Skin-nan-24m-Mesenchymal-nan\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CD248 FAT3 PKDCC ZNF521	9.22e-05	185	57	4	63200c42565eea596f9b00728e70e544b8d50a7f
ToppCell	COVID-19-kidney-Mito-rich_PCT\|COVID-19 / Disease (COVID-19 only), tissue and cell type	AOX1 LRP2 PPARA WWC1	9.22e-05	185	57	4	1bbc2ba8a20f72f61981b1301cdd6018cdd9150d
ToppCell	droplet-Heart-4Chambers-18m-Mesenchymal-fibroblast\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FBLN1 LDLRAD1 LTBP3 PROC	9.41e-05	186	57	4	35c88cc4eb388811fcac4323b549e5897fa8dc27
ToppCell	droplet-Heart-nan-3m-Endothelial\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	THBD HMCN1 ITGB1 PKHD1L1	9.41e-05	186	57	4	0ae5fbe9f210cb25092394267e1d3d6ed05627b8
ToppCell	Epithelial-alveolar_epithelial_cell_type_1\|World / Lineage, Cell type, age group and donor	PKDCC CTNND2 FBN3 WWC1	9.41e-05	186	57	4	09d95daa3387a4814cffaa4b798cc2810c3759d0
ToppCell	droplet-Heart-4Chambers-18m-Mesenchymal-fibroblast_of_cardiac_tissue\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FBLN1 LDLRAD1 LTBP3 PROC	9.41e-05	186	57	4	d998c5b00083cf2a7cd5341a98b7374b4de73c63
ToppCell	Healthy-multiplets\|Healthy / disease group, cell group and cell class	TUBB1 THBD CTNND2 PKHD1L1	9.41e-05	186	57	4	2ec999b97e95afb898f8083042b0f188d3d234bc
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_3\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	AOX1 LRP2 PPARA WWC1	9.41e-05	186	57	4	b1edc341d6684b347dc9e21b34f62f51d095d735
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	AFM AOX1 LRP2 PPARA	9.61e-05	187	57	4	dcf6475ece5b34d9d58a0d1f51c18acedb19c119
ToppCell	droplet-Pancreas-Exocrine-18m-Mesenchymal-pancreatic_stellate_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FBLN1 CD248 LRP2 PKHD1L1	9.61e-05	187	57	4	4e553721fa5598cb211f44e3226280b7e6885484
ToppCell	droplet-Pancreas-Exocrine-18m-Mesenchymal\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FBLN1 CD248 LRP2 PKHD1L1	9.61e-05	187	57	4	d36e7fc6125e7a4310499365022d38f34b757a73
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_1-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	PKDCC CTNND2 FBN3 WWC1	9.61e-05	187	57	4	d4b0afd9b92c47c8aa348bbd1af7eb54c3d478f2
ToppCell	droplet-Pancreas-Exocrine-18m-Mesenchymal-pancreatic_stellate_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FBLN1 CD248 LRP2 PKHD1L1	9.61e-05	187	57	4	827eae63fabf6892a82ce7779b5f395958d3d628
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	AFM AOX1 LRP2 PPARA	9.61e-05	187	57	4	f1356273bd3587b6883295edf15cb9cdb706c057
ToppCell	systemic_lupus_erythematosus-flare-Myeloid-plasmacytoid_dendritic_cell-male\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	ZNF521 WDFY2 PROC MYBL2	9.61e-05	187	57	4	d3563bb087e476baea5b59389e4d34d0ff98cac5
ToppCell	Control-Fibroblasts-Other_FB\|Control / group, cell type (main and fine annotations)	FBLN1 HMCN1 FAT3 ZNF521	9.61e-05	187	57	4	bd3739c4a52aa1ba5deffd778e113a9800f7e158
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Endothelial-lymphatic_endothelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	TUBB1 THBD ZNF521 PKHD1L1	9.81e-05	188	57	4	26915db8863f4115b46a81982e187322e21600fd
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_cortex\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	TUBB1 THBD ZNF521 PKHD1L1	9.81e-05	188	57	4	3f76c0f912f8f023ea425be7f43593b3d7f967e3
Drug	quercetin dihydrate; Up 200; 1uM; MCF7; HT_HG-U133A_EA	SNED1 THBD CACNA1H PRR14L PPARA CTNND2 ZZEF1	5.78e-07	196	57	7	917_UP
Disease	Drug toxicity	THBD AFM CACNA1H PPARA	2.00e-05	84	56	4	C0013221
Disease	Adverse reaction to drug	THBD AFM CACNA1H PPARA	2.00e-05	84	56	4	C0041755
Disease	Diaphragmatic Hernia	KCNA2 KCNB1 LRP2	6.56e-05	41	56	3	C0019284
Disease	Disseminated Intravascular Coagulation	THBD PROC	7.38e-05	7	56	2	C0012739
Disease	acute kidney failure (is_implicated_in)	THBD PROC	1.58e-04	10	56	2	DOID:3021 (is_implicated_in)
Disease	GM3 ganglioside measurement	CTNND2 FBN3	1.92e-04	11	56	2	EFO_0021451
Disease	Craniofacial Abnormalities	APAF1 LRP2 SALL4 LTBP3	2.23e-04	156	56	4	C0376634
Disease	lung non-small cell carcinoma (is_marker_for)	THBD CSF1R APAF1 ITGB1	3.02e-04	169	56	4	DOID:3908 (is_marker_for)
Disease	lung small cell carcinoma (is_marker_for)	CSF1R ITGB1	4.17e-04	16	56	2	DOID:5409 (is_marker_for)
Disease	vital capacity	HMCN1 SYNE1 LRP2 PKDCC LTBP3 ZZEF1 PLXNA1 FBN3 PROC	4.95e-04	1236	56	9	EFO_0004312
Disease	ischemia (biomarker_via_orthology)	THBD MUC2	5.31e-04	18	56	2	DOID:326 (biomarker_via_orthology)
Disease	Liver Cirrhosis, Experimental	PLEKHH1 THBD CSF1R AFM APAF1 ITGB1 LRRFIP1	6.31e-04	774	56	7	C0023893
Disease	NEPHROTIC SYNDROME, STEROID-RESISTANT, AUTOSOMAL RECESSIVE	NUP133 CRB2	1.49e-03	30	56	2	C1868672
Disease	putamen volume	FAT3 CTNND2	1.59e-03	31	56	2	EFO_0006932
Disease	eosinophil count	SLAMF6 GSE1 NUP133 CACNA1H LTBP3 PPARA CLSTN1 MUC2 UVRAG	1.83e-03	1488	56	9	EFO_0004842

Protein segments in the cluster

Peptide	Gene	Start	Entry
HEDEVLCCAFSTDDR	APAF1	656	O14727
CHVDVDECRTSITLC	EGFL8	141	Q99944
VAVHFEEVAKSCCEE	AFM	181	P43652
CVEEVDGHVSCRCTE	CD248	246	Q9HCU0
SDEEEVRAHLRCVAE	GSE1	766	Q14687
EEIVHDLDTCEVTVE	CLSTN1	711	O94985
TEDHRACQDVDECAQ	FBN3	1396	Q75N90
LSEHTRICEDIDECS	FBN3	1596	Q75N90
RICEDIDECSTHSGI	FBN3	1601	Q75N90
QVQSDHCIDIDECSE	FBN3	1961	Q75N90
SDDTVTAVCCTLHEV	CTNND2	956	Q9UQB3
EEVETSICECQDENH	ASXL3	456	Q9C0F0
AACSEVEIDCLTGDH	AOX1	1166	Q06278
VVVHVCESETEEEEE	RCAN3	196	Q9UKA8
VGRHCECSTDEVNSE	ITGB1	496	P05556
VDTICECLLEHEEQV	NUP133	696	Q8WUM0
EADHECCERVVINIS	KCNA2	26	P16389
VDVCTTDRSHLEECL	WWC1	746	Q8IX03
EGTHCEREVLECASA	CRB2	216	Q5IJ48
RECHIVVLTDEDSVD	KCTD20	256	Q7Z5Y7
ESEDREEVVVCELCE	HERC1	2971	Q15751
EEVVVCELCECSVVS	HERC1	2976	Q15751
CHECLELENSTIESV	HLCS	106	P50747
RAHDALVEVCVRDCS	PLXNA1	931	Q9UIW2
EEVAPASCSEHRAEC	MUC2	211	Q02817
HQARLECDEECSALE	NFX1	941	Q12986
TCTHGEDEDESLCRD	LDLRAD1	101	Q5T700
RDSSDEINCTEICLH	LRP2	171	P98164
VVDRESSHDECQDAV	NBPF1	241	Q3BBV0
SHDTCVDIDECENTD	HMCN1	5426	Q96RW7
RHSSLERECIEEICD	PROC	51	P04070
HLNEEGTRCVDVDEC	FBLN1	346	P23142
ELEEESSSEHLTCCE	CSF1R	941	P07333
RDCNTHDSLLEVCDD	KCNB1	61	Q14721
TGVTCEEDINECERE	FAT3	4091	Q8TDW7
HLSRDRSHCEDIDEC	LTBP3	816	Q9NS15
TESHSVCDDIECELE	CEP57L1	351	Q8IYX8
ELDDDSEDSCCLRLH	CACNA1H	1241	O95180
AICHDDVIESIDVEE	SALL4	681	Q9UJQ4
CTRQHCTEEDEEEDE	PPP4R2	291	Q9NY27
ACEAESTERCEMSEH	LRRFIP1	741	Q32MZ4
HVESCCEETYETLDH	PRR14L	71	Q5THK1
AEILTCEHDIEDSET	PPARA	186	Q07869
TFRCTFCHTEVEEDE	GTF2E1	151	P29083
SEAELCCTVEQAEEI	UVRAG	621	Q9P2Y5
DEEAICVVCRESRSH	TRIM41	241	Q8WV44
LAADQHRCEDVDDCI	THBD	316	P07204
AEAVDVCESHAQCRA	PKDCC	441	Q504Y2
TCELHLTCSVEDADD	SLAMF6	146	Q96DU3
EVLLHDCDACATDAE	SYNE1	7951	Q8NF91
SCWTEEEDRIICEAH	MYBL2	136	P10244
VLEVVRHESESCDCL	TUBB1	116	Q9H4B7
ATEEAVRERVICCTE	MRI1	116	Q9BV20
FVGVHCETEVDACDS	SNED1	821	Q8TER0
VRVCDSCHEAITDEE	WDFY2	341	Q96P53
LEDEAVHSCDSCLQV	ZNF521	41	Q96K83
VVEESSEDSITCHID	PKHD1L1	1606	Q86WI1
VRDAHIEEVDRSCDS	PLEKHH1	731	Q9ULM0
EQSVTCAHCRKDTEE	ZZEF1	711	O43149
LCEECSERIAGDHSE	UNC79	341	Q9P2D8
FDVTRGCHESCLDEE	TPP1	516	O14773