Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	-	DLX3 DLX4 OTX2 DBX2 MYB	4.15e-04	283	42	5	1.10.10.60
Domain	HTH_motif	DLX3 DLX4 DBX2	5.00e-04	69	42	3	IPR000047
Domain	Homeobox_CS	DLX3 DLX4 OTX2 DBX2	7.93e-04	186	42	4	IPR017970
Domain	Homeodomain-like	DLX3 DLX4 OTX2 DBX2 MYB	8.54e-04	332	42	5	IPR009057
Domain	Homeobox_metazoa	DLX3 DLX4 DBX2	1.08e-03	90	42	3	IPR020479
Domain	Homeobox	DLX3 DLX4 OTX2 DBX2	1.85e-03	234	42	4	PF00046
Domain	HOMEOBOX_1	DLX3 DLX4 OTX2 DBX2	1.91e-03	236	42	4	PS00027
Domain	HOX	DLX3 DLX4 OTX2 DBX2	1.94e-03	237	42	4	SM00389
Domain	Homeobox_dom	DLX3 DLX4 OTX2 DBX2	2.00e-03	239	42	4	IPR001356
Domain	HOMEOBOX_2	DLX3 DLX4 OTX2 DBX2	2.00e-03	239	42	4	PS50071
Domain	PH	PLEKHG2 AGAP7P ARHGAP20 ARHGEF5	3.45e-03	278	42	4	SM00233
Domain	PH_DOMAIN	PLEKHG2 AGAP7P ARHGAP20 ARHGEF5	3.49e-03	279	42	4	PS50003
Domain	PH_domain	PLEKHG2 AGAP7P ARHGAP20 ARHGEF5	3.54e-03	280	42	4	IPR001849
Domain	Ubiquitin-rel_dom	SHARPIN ARHGAP20 SACS	8.15e-03	184	42	3	IPR029071
Domain	DH_1	PLEKHG2 ARHGEF5	8.84e-03	63	42	2	PS00741
Domain	RhoGEF	PLEKHG2 ARHGEF5	1.02e-02	68	42	2	SM00325
Domain	DH_2	PLEKHG2 ARHGEF5	1.08e-02	70	42	2	PS50010
Domain	RhoGEF	PLEKHG2 ARHGEF5	1.08e-02	70	42	2	PF00621
Domain	DH-domain	PLEKHG2 ARHGEF5	1.11e-02	71	42	2	IPR000219
Domain	-	PLEKHG2 ARHGEF5	1.11e-02	71	42	2	1.20.900.10
Domain	4_helix_cytokine-like_core	CSF3 SACS	1.20e-02	74	42	2	IPR009079
Pathway	REACTOME_CDC42_GTPASE_CYCLE	PLEKHG2 ARHGAP20 ARHGEF5 SHKBP1	1.49e-04	155	25	4	M41808
Pubmed	Genomic structure and functional control of the Dlx3-7 bigene cluster.	DLX3 DLX4	1.56e-06	2	44	2	11792834
Pubmed	Identification of a mutation in DLX3 associated with tricho-dento-osseous (TDO) syndrome.	DLX3 DLX4	1.56e-06	2	44	2	9467018
Pubmed	Genomic analysis of a new mammalian distal-less gene: Dlx7.	DLX3 DLX4	1.56e-06	2	44	2	8975708
Pubmed	Disruption of GMNC-MCIDAS multiciliogenesis program is critical in choroid plexus carcinoma development.	OTX2 GDF7 MYB	3.75e-06	24	44	3	35322202
Pubmed	Spatially restricted expression of a member of a new family of murine Distal-less homeobox genes in the developing forebrain.	DLX3 DLX4	4.69e-06	3	44	2	1687503
Pubmed	Genetic variant in the BCL11A (rs1427407), but not HBS1-MYB (rs6934903) loci associate with fetal hemoglobin levels in Indian sickle cell disease patients.	MYB SHKBP1	4.69e-06	3	44	2	25457385
Pubmed	Expression of Dlx genes during the development of the murine dentition.	DLX3 DLX4	2.34e-05	6	44	2	11180832
Pubmed	Differential expression of orthologous Dlx genes in zebrafish and mice: implications for the evolution of the Dlx homeobox gene family.	DLX3 DLX4	2.34e-05	6	44	2	11069141
Pubmed	Homeobox gene Dlx3 is regulated by p63 during ectoderm development: relevance in the pathogenesis of ectodermal dysplasias.	DLX3 DLX4	3.27e-05	7	44	2	17164413
Pubmed	Generation of regionally specified neurons in expanded glial cultures derived from the mouse and human lateral ganglionic eminence.	DLX3 DLX4	4.36e-05	8	44	2	11358480
Pubmed	Roles for Msx and Dlx homeoproteins in vertebrate development.	DLX3 DLX4	4.36e-05	8	44	2	10773441
Pubmed	Dlx and other homeobox genes in the morphological development of the dentition.	DLX3 DLX4	6.99e-05	10	44	2	7554933
Pubmed	Expression of Neurogenin 1 in mouse embryonic stem cells directs the differentiation of neuronal precursors and identifies unique patterns of down-stream gene expression.	OTX2 DBX2	8.54e-05	11	44	2	23288605
Pubmed	Retinoids are produced by glia in the lateral ganglionic eminence and regulate striatal neuron differentiation.	DLX3 DLX4	1.02e-04	12	44	2	10021349
Pubmed	Dlx transcription factors regulate differentiation of dopaminergic neurons of the ventral thalamus.	DLX3 DLX4	1.21e-04	13	44	2	12799141
Pubmed	Pax6 regulates the identity of embryonic diencephalic neurons.	DLX3 DLX4	1.21e-04	13	44	2	11161479
Pubmed	Molecular interaction between projection neuron precursors and invading interneurons via stromal-derived factor 1 (CXCL12)/CXCR4 signaling in the cortical subventricular zone/intermediate zone.	DLX3 DLX4	1.41e-04	14	44	2	17182777
Pubmed	The mouse Ovol2 gene is required for cranial neural tube development.	DLX3 OTX2	1.86e-04	16	44	2	16423343
Pubmed	A role for the mesenchymal T-box gene Brachyury in AER formation during limb development.	DLX3 DLX4	1.86e-04	16	44	2	12588849
Pubmed	Discovery of transcriptional regulators and signaling pathways in the developing pituitary gland by bioinformatic and genomic approaches.	DLX3 OTX2	1.86e-04	16	44	2	19121383
Pubmed	Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.	LINC00696 AATK CAMSAP1 ARHGEF5 STON2	2.06e-04	430	44	5	35044719
Pubmed	MOZ directs the distal-less homeobox gene expression program during craniofacial development.	DLX3 DLX4	2.10e-04	17	44	2	31340933
Pubmed	Structural analysis and chromosomal localization of the mouse Psmb5 gene coding for the constitutively expressed beta-type proteasome subunit.	OTX2 CSF3	2.10e-04	17	44	2	9382924
Pubmed	Sonic hedgehog is required for vascular outgrowth in the hindbrain choroid plexus.	OTX2 GDF7	2.36e-04	18	44	2	20123094
Pubmed	Regulation of hematopoietic cell clusters in the placental niche through SCF/Kit signaling in embryonic mouse.	CSF3 MYB	2.64e-04	19	44	2	20980401
Pubmed	Ventral specification and perturbed boundary formation in the mouse midbrain in the absence of Hedgehog signaling.	OTX2 GDF7	2.64e-04	19	44	2	18429041
Pubmed	Unravelling the complex genetics of cleft lip in the mouse model.	DLX3 DLX4	2.64e-04	19	44	2	11353389
Pubmed	Three-dimensional molecular architecture of mouse organogenesis.	DLX3 DLX4 OTX2	2.80e-04	100	44	3	37524711
Pubmed	Identification of nine novel loci associated with white blood cell subtypes in a Japanese population.	CSF3 MYB	2.93e-04	20	44	2	21738478
Pubmed	A refined map of early gene expression in the dorsal rhombomere 1 of mouse embryos.	OTX2 GDF7	3.24e-04	21	44	2	20206242
Pubmed	AML1(-/-) embryos do not express certain hematopoiesis-related gene transcripts including those of the PU.1 gene.	CSF3 MYB	3.56e-04	22	44	2	9811459
Pubmed	AP-2α and AP-2β cooperatively orchestrate homeobox gene expression during branchial arch patterning.	DLX3 DLX4	3.56e-04	22	44	2	29229773
Pubmed	Shh signaling within the dental epithelium is necessary for cell proliferation, growth and polarization.	DLX3 DLX4	4.24e-04	24	44	2	12403705
Pubmed	DDX3X Suppresses the Susceptibility of Hindbrain Lineages to Medulloblastoma.	IRF1 OTX2	4.24e-04	24	44	2	32553121
Pubmed	The human and mouse receptors for hyaluronan-mediated motility, RHAMM, genes (HMMR) map to human chromosome 5q33.2-qter and mouse chromosome 11.	IRF1 CSF3	5.38e-04	27	44	2	8595891
Pubmed	Gli3 coordinates three-dimensional patterning and growth of the tectum and cerebellum by integrating Shh and Fgf8 signaling.	OTX2 GDF7	5.38e-04	27	44	2	18480159
Pubmed	ZFP423 regulates early patterning and multiciliogenesis in the hindbrain choroid plexus.	OTX2 GDF7	5.79e-04	28	44	2	33046507
Pubmed	Correct patterning of the primitive streak requires the anterior visceral endoderm.	OTX2 GDF7	6.65e-04	30	44	2	21445260
Pubmed	Loss of Neogenin alters branchial arch development and leads to craniofacial skeletal defects.	DLX3 DLX4	6.65e-04	30	44	2	38404688
Pubmed	Nkx6-1 controls the identity and fate of red nucleus and oculomotor neurons in the mouse midbrain.	OTX2 DBX2	7.11e-04	31	44	2	19592574
Pubmed	The Functional Proximal Proteome of Oncogenic Ras Includes mTORC2.	CAMSAP1 AUP1 DCBLD2 TMEM94 STON2	7.39e-04	569	44	5	30639242
Pubmed	The transcription factor Otx2 regulates choroid plexus development and function.	OTX2 GDF7	8.06e-04	33	44	2	23364326
Pubmed	A census of human transcription factors: function, expression and evolution.	IRF1 DLX3 DLX4 OTX2 DBX2 MYB	9.43e-04	908	44	6	19274049
Cytoband	17q21.33	XYLT2 DLX4	7.52e-04	41	45	2	17q21.33
Cytoband	Ensembl 112 genes in cytogenetic band chr17q21	XYLT2 DLX3 DLX4 CSF3	1.19e-03	473	45	4	chr17q21
Cytoband	9q34.3	CAMSAP1 MAMDC4	4.90e-03	106	45	2	9q34.3
Cytoband	8q24.3	SHARPIN RHPN1	5.55e-03	113	45	2	8q24.3
GeneFamily	NKL subclass homeoboxes and pseudogenes	DLX3 DLX4 DBX2	1.06e-04	67	25	3	519
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	PLEKHG2 ARHGEF5	3.73e-03	66	25	2	722
Disease	Scleroderma	XYLT2 CSF3	1.18e-05	4	42	2	C0011644
Disease	coagulation factor V measurement	DLX3 DLX4	3.70e-04	20	42	2	EFO_0008087
Disease	vasculitis	IRF1 KDM4C	5.35e-04	24	42	2	EFO_0006803
Disease	asthma, cardiovascular disease	IRF1 CSF3	8.39e-04	30	42	2	EFO_0000319, MONDO_0004979
Disease	lung disease (biomarker_via_orthology)	IRF1 CSF3	1.14e-03	35	42	2	DOID:850 (biomarker_via_orthology)
Disease	Childhood Medulloblastoma	OTX2 KDM4C	1.72e-03	43	42	2	C0278510
Disease	Melanotic medulloblastoma	OTX2 KDM4C	1.72e-03	43	42	2	C1275668

Protein segments in the cluster

Peptide	Gene	Start	Entry
SEPLPATPASCLRFW	MAMDC4	1041	Q6UXC1
WLPPAIFRSSCPISV	CHRND	141	Q07001
ISLHPWLPSPCSSDS	nan	236	Q9N2J8
LWSLFAPSSPIPRCS	ADAMTSL4	351	Q6UY14
LWACTAACPPSLSPT	LINC00696	101	Q6ZRV3
FLCPSSPTTPWTPEL	ARHGEF5	931	Q12774
TPDASESCPAPLTTW	CAMSAP1	841	Q5T5Y3
ACNSPPSPALWDTSS	DLX3	206	O60479
TFSVSPCSPPLPSLW	DLX4	191	Q92988
PALSPCAVSSTLPDW	IRF1	181	P10914
PPQSPLDSCSSPLLW	MAGEC3	411	Q8TD91
LPACSARPDTSPLWL	KMT5C	306	Q86Y97
WATELPAPSSLSTPL	C9orf131	681	Q5VYM1
DPSELSWPKSPESCS	KDM4C	501	Q9H3R0
SLASPLQPCSSTWEP	MYB	596	P10242
LASTPALWASIPCPR	OGG1	16	O15527
LTWTAQPPCLSVTPS	RBM12B-AS1	61	Q9P1G2
DFSLSQSWPSCLPPP	CCDC182	31	A6NF36
SPDPTLFCSLLTSWP	PATL2	131	C9JE40
PGLNVSSPFSSPWTC	C5orf67	91	F2Z3F1
PWVPSLFSCTLPLIL	GFRA3	381	O60609
SRSALGFPSPCPSIW	DBX2	266	Q6ZNG2
WPSLATLACTPISSS	AGAP7P	321	Q5VUJ5
SLGIPWAPLSSCPSQ	CSF3	86	P09919
AWAALPLSRSLPPCS	DCBLD2	26	Q96PD2
WTSCPILPEKATPLS	SACS	3701	Q9NZJ4
IWSPASISPLSDPLS	OTX2	151	P32243
LCWSLAIATPLPPTS	HPX	16	P02790
VCVAPSILWPPASSS	ARHGAP20	511	Q9P2F6
TPDPFLPSLDACWSP	RPUSD1	226	Q9UJJ7
WDPCPASELLPHTSS	SYT15	101	Q9BQS2
PAPCLVTPSWTETAS	AATK	756	Q6ZMQ8
PGSWTSPPLLLLSTC	GDF7	171	Q7Z4P5
TWLSTECDSHPLPPS	KNSTRN	16	Q9Y448
TPACGPFSALTPSIW	SGSM3	6	Q96HU1
NFSPCPRPWLSSSFP	TMEM69	41	Q5SWH9
SWGCLPSPSPRISLT	SHKBP1	616	Q8TBC3
SPLQPSWSCPSCTFI	SHARPIN	346	Q9H0F6
CKTPASTWASPRPLL	RHPN1	621	Q8TCX5
LPLTMPCWTCPSFDS	STON2	126	Q8WXE9
TLPSDWSYTLSPPSL	CIART	341	Q8N365
CSTPLLNSPPSFVCW	AUP1	111	Q9Y679
PPLLSTTDILWLSCF	TMEM94	1116	Q12767
SCPSSWRSADPTVSP	nan	81	Q6ZSV7
LSSSLAPTWLSPTEP	VASN	371	Q6EMK4
CPSSWTPLPLTDSWV	VWA5B2	6	Q8N398
PSLSSTPTLSCDSWL	PLEKHG2	681	Q9H7P9
SPCPSLEPCRLTSWS	XYLT2	831	Q9H1B5
PLASFSPAQPSSWLS	nan	196	Q6ZQT7