Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionkainate selective glutamate receptor activity

GRIK1 GRIK2 GRIK3

5.95e-076633GO:0015277
GeneOntologyMolecularFunctionligand-gated calcium channel activity

GRIK1 RYR2 RYR3 ITPR3

2.66e-0631634GO:0099604
GeneOntologyMolecularFunctionligand-gated monoatomic cation channel activity

GRIK1 GRIK2 GRIK3 RYR2 RYR3 ITPR3

5.22e-06140636GO:0099094
GeneOntologyMolecularFunctionglutamate-gated receptor activity

GRIK1 GRIK2 GRIK3

1.97e-0517633GO:0004970
GeneOntologyMolecularFunctionligand-gated sodium channel activity

GRIK1 GRIK2 GRIK3

2.36e-0518633GO:0015280
GeneOntologyMolecularFunctionintracellularly gated calcium channel activity

RYR2 RYR3 ITPR3

2.36e-0518633GO:0015278
GeneOntologyMolecularFunctionligand-gated monoatomic ion channel activity

GRIK1 GRIK2 GRIK3 RYR2 RYR3 ITPR3

3.24e-05193636GO:0015276
GeneOntologyMolecularFunctionligand-gated channel activity

GRIK1 GRIK2 GRIK3 RYR2 RYR3 ITPR3

3.64e-05197636GO:0022834
GeneOntologyMolecularFunctionligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential

GRIK1 GRIK2 GRIK3

5.78e-0524633GO:0099507
GeneOntologyMolecularFunctionryanodine-sensitive calcium-release channel activity

RYR2 RYR3

5.85e-054632GO:0005219
GeneOntologyMolecularFunctionglutamate receptor activity

GRIK1 GRIK2 GRIK3

8.29e-0527633GO:0008066
GeneOntologyMolecularFunctioncalcium-induced calcium release activity

RYR2 RYR3

1.46e-046632GO:0048763
GeneOntologyMolecularFunctionintracellularly ligand-gated monoatomic ion channel activity

RYR2 RYR3 ITPR3

1.53e-0433633GO:0005217
GeneOntologyMolecularFunctionextracellularly glutamate-gated ion channel activity

GRIK1 GRIK2

2.04e-047632GO:0005234
GeneOntologyMolecularFunctionscaffold protein binding

XIAP GRIK1 GRIK2 RYR2

2.13e-0493634GO:0097110
GeneOntologyMolecularFunctionmonoatomic ion channel activity

LRRC8A GRIK1 GRIK2 GRIK3 RYR2 RYR3 ITPR3

5.90e-04459637GO:0005216
GeneOntologyMolecularFunctionsodium channel activity

GRIK1 GRIK2 GRIK3

5.92e-0452633GO:0005272
GeneOntologyMolecularFunctionmetal ion transmembrane transporter activity

NIPAL4 GRIK1 GRIK2 GRIK3 RYR2 RYR3 ITPR3

6.37e-04465637GO:0046873
GeneOntologyMolecularFunctiongated channel activity

GRIK1 GRIK2 GRIK3 RYR2 RYR3 ITPR3

6.38e-04334636GO:0022836
GeneOntologyMolecularFunctionmonoatomic cation channel activity

GRIK1 GRIK2 GRIK3 RYR2 RYR3 ITPR3

7.33e-04343636GO:0005261
GeneOntologyMolecularFunctioncalcium channel activity

GRIK1 RYR2 RYR3 ITPR3

7.37e-04129634GO:0005262
GeneOntologyMolecularFunctiontransmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential

GRIK1 GRIK2 GRIK3

7.76e-0457633GO:1904315
GeneOntologyMolecularFunctionSNARE binding

TXLNA TXLNB GRIK1 GRIK2

8.98e-04136634GO:0000149
GeneOntologyMolecularFunctionneurotransmitter receptor activity involved in regulation of postsynaptic membrane potential

GRIK1 GRIK2 GRIK3

9.01e-0460633GO:0099529
GeneOntologyMolecularFunctiontransmitter-gated channel activity

GRIK1 GRIK2 GRIK3

1.14e-0365633GO:0022835
GeneOntologyMolecularFunctiontransmitter-gated monoatomic ion channel activity

GRIK1 GRIK2 GRIK3

1.14e-0365633GO:0022824
GeneOntologyMolecularFunctionchannel activity

LRRC8A GRIK1 GRIK2 GRIK3 RYR2 RYR3 ITPR3

1.29e-03525637GO:0015267
GeneOntologyMolecularFunctionpassive transmembrane transporter activity

LRRC8A GRIK1 GRIK2 GRIK3 RYR2 RYR3 ITPR3

1.31e-03526637GO:0022803
GeneOntologyMolecularFunctioncalcium ion transmembrane transporter activity

GRIK1 RYR2 RYR3 ITPR3

1.32e-03151634GO:0015085
GeneOntologyMolecularFunctionpostsynaptic neurotransmitter receptor activity

GRIK1 GRIK2 GRIK3

1.72e-0375633GO:0098960
GeneOntologyMolecularFunctionextracellular ligand-gated monoatomic ion channel activity

GRIK1 GRIK2 GRIK3

1.85e-0377633GO:0005230
GeneOntologyMolecularFunctionprotein serine/threonine kinase binding

CLTC XIAP

2.59e-0324632GO:0120283
GeneOntologyMolecularFunctionmonoatomic ion transmembrane transporter activity

NIPAL4 LRRC8A GRIK1 GRIK2 GRIK3 RYR2 RYR3 ITPR3

3.35e-03793638GO:0015075
GeneOntologyMolecularFunctioninorganic cation transmembrane transporter activity

NIPAL4 GRIK1 GRIK2 GRIK3 RYR2 RYR3 ITPR3

3.51e-03627637GO:0022890
GeneOntologyMolecularFunctionneurotransmitter receptor activity

GRIK1 GRIK2 GRIK3

3.89e-03100633GO:0030594
GeneOntologyMolecularFunctionamino acid transmembrane transporter activity

GRIK1 GRIK2 GRIK3

4.46e-03105633GO:0015171
GeneOntologyMolecularFunctionmonoatomic cation transmembrane transporter activity

NIPAL4 GRIK1 GRIK2 GRIK3 RYR2 RYR3 ITPR3

4.80e-03664637GO:0008324
GeneOntologyMolecularFunctionlow-density lipoprotein particle receptor binding

CLTC LRP2

5.15e-0334632GO:0050750
GeneOntologyMolecularFunctioncalmodulin binding

STRN3 SPTAN1 RYR2 RYR3

6.01e-03230634GO:0005516
GeneOntologyMolecularFunctionlipoprotein particle receptor binding

CLTC LRP2

6.73e-0339632GO:0070325
GeneOntologyBiologicalProcessnegative regulation of synaptic transmission, glutamatergic

GRIK1 GRIK2 GRIK3

7.24e-0613623GO:0051967
GeneOntologyBiologicalProcessionotropic glutamate receptor signaling pathway

GRIK1 GRIK2 GRIK3

7.19e-0527623GO:0035235
GeneOntologyBiologicalProcessinhibitory postsynaptic potential

ABAT GRIK1 GRIK2

7.19e-0527623GO:0060080
GeneOntologyCellularComponentkainate selective glutamate receptor complex

GRIK1 GRIK2 GRIK3

5.18e-076633GO:0032983
GeneOntologyCellularComponentsodium channel complex

GRIK1 GRIK2 GRIK3

9.01e-0529633GO:0034706
GeneOntologyCellularComponentionotropic glutamate receptor complex

GRIK1 GRIK2 GRIK3

3.38e-0445633GO:0008328
GeneOntologyCellularComponentneurotransmitter receptor complex

GRIK1 GRIK2 GRIK3

4.62e-0450633GO:0098878
GeneOntologyCellularComponentcation channel complex

GRIK1 GRIK2 GRIK3 RYR2 RYR3

7.11e-04235635GO:0034703
GeneOntologyCellularComponentCul4A-RING E3 ubiquitin ligase complex

CUL4B CUL4A

7.95e-0414632GO:0031464
GeneOntologyCellularComponentmonoatomic ion channel complex

LRRC8A GRIK1 GRIK2 GRIK3 RYR2 RYR3

9.58e-04378636GO:0034702
DomainRIH_assoc

RYR2 RYR3 ITPR3

6.58e-076613PF08454
DomainRIH_assoc-dom

RYR2 RYR3 ITPR3

6.58e-076613IPR013662
DomainRIH_dom

RYR2 RYR3 ITPR3

6.58e-076613IPR000699
DomainIns145_P3_rcpt

RYR2 RYR3 ITPR3

6.58e-076613IPR014821
DomainRyanodine_recept-rel

RYR2 RYR3 ITPR3

6.58e-076613IPR015925
Domain-

RYR2 RYR3 ITPR3

6.58e-0766131.25.10.30
DomainRYDR_ITPR

RYR2 RYR3 ITPR3

6.58e-076613PF01365
DomainIns145_P3_rec

RYR2 RYR3 ITPR3

6.58e-076613PF08709
DomainMIR

RYR2 RYR3 ITPR3

3.91e-0610613PS50919
DomainMIR

RYR2 RYR3 ITPR3

3.91e-0610613PF02815
DomainMIR

RYR2 RYR3 ITPR3

3.91e-0610613SM00472
DomainMIR_motif

RYR2 RYR3 ITPR3

3.91e-0610613IPR016093
DomainIontro_rcpt

GRIK1 GRIK2 GRIK3

2.61e-0518613IPR001320
DomainLig_chan-Glu_bd

GRIK1 GRIK2 GRIK3

2.61e-0518613PF10613
DomainIono_rcpt_met

GRIK1 GRIK2 GRIK3

2.61e-0518613IPR001508
DomainGlu/Gly-bd

GRIK1 GRIK2 GRIK3

2.61e-0518613IPR019594
DomainLig_chan-Glu_bd

GRIK1 GRIK2 GRIK3

2.61e-0518613SM00918
DomainLig_chan

GRIK1 GRIK2 GRIK3

2.61e-0518613PF00060
DomainPBPe

GRIK1 GRIK2 GRIK3

2.61e-0518613SM00079
DomainRyanrecept_TM4-6

RYR2 RYR3

3.14e-053612IPR009460
DomainTaxilin_fam

TXLNA TXLNB

3.14e-053612IPR026183
DomainRyR

RYR2 RYR3

3.14e-053612PF02026
DomainRyanodine_rcpt

RYR2 RYR3

3.14e-053612IPR003032
DomainRR_TM4-6

RYR2 RYR3

3.14e-053612PF06459
DomainRyan_recept

RYR2 RYR3

3.14e-053612IPR013333
DomainTaxilin

TXLNA TXLNB

6.27e-054612PF09728
DomainCullin_CS

CUL4B CUL4A

2.18e-047612IPR016157
DomainCULLIN

CUL4B CUL4A

2.18e-047612SM00182
DomainANF_lig-bd_rcpt

GRIK1 GRIK2 GRIK3

2.38e-0437613IPR001828
DomainANF_receptor

GRIK1 GRIK2 GRIK3

2.38e-0437613PF01094
DomainPeripla_BP_I

GRIK1 GRIK2 GRIK3

2.79e-0439613IPR028082
DomainCullin_Nedd8

CUL4B CUL4A

2.90e-048612PF10557
DomainCullin_Nedd8

CUL4B CUL4A

2.90e-048612SM00884
DomainCullin_neddylation_domain

CUL4B CUL4A

2.90e-048612IPR019559
DomainCullin_homology

CUL4B CUL4A

3.72e-049612IPR016158
DomainLipase/vitellogenin

LIPC LIPI

4.64e-0410612IPR013818
DomainTAG_lipase

LIPC LIPI

4.64e-0410612IPR000734
DomainCullin

CUL4B CUL4A

4.64e-0410612PF00888
DomainCULLIN_2

CUL4B CUL4A

4.64e-0410612PS50069
DomainLipase_LIPH

LIPC LIPI

4.64e-0410612IPR016272
DomainLipase

LIPC LIPI

4.64e-0410612PF00151
DomainLipase_N

LIPC LIPI

4.64e-0410612IPR033906
DomainCullin_N

CUL4B CUL4A

4.64e-0410612IPR001373
DomainCULLIN_1

CUL4B CUL4A

4.64e-0410612PS01256
DomainCullin_repeat-like_dom

CUL4B CUL4A

6.78e-0412612IPR016159
DomainARM-type_fold

PPP2R5B PIK3CG RRP12 TTC12 CLTC RYR3

8.20e-04339616IPR016024
DomainEF-hand_1

CETN2 SPTAN1 RYR2 RYR3

1.54e-03152614PF00036
DomainSpectrin

SYNE1 SPTAN1

2.54e-0323612PF00435
DomainLIPASE_SER

LIPC LIPI

3.24e-0326612PS00120
DomainSpectrin_repeat

SYNE1 SPTAN1

4.02e-0329612IPR002017
DomainSpectrin/alpha-actinin

SYNE1 SPTAN1

4.89e-0332612IPR018159
DomainSPEC

SYNE1 SPTAN1

4.89e-0332612SM00150
DomainIon_trans_dom

RYR2 RYR3 ITPR3

6.16e-03114613IPR005821
DomainIon_trans

RYR2 RYR3 ITPR3

6.16e-03114613PF00520
PathwayREACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS

GRIK1 GRIK2 GRIK3

4.95e-0610503M10272
PathwayKEGG_MEDICUS_PATHOGEN_HIV_VPR_TO_CDC25_CELL_CYCLE_G2M

CUL4B CUL4A CCNB3

6.79e-0611503M47573
PathwayWP_VALPROIC_ACID_PATHWAY

ABAT ACADSB HADHA

9.03e-0612503M39371
PathwayREACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS

GRIK1 GRIK2 GRIK3

9.03e-0612503MM15142
PathwayKEGG_MEDICUS_VARIANT_SCRAPIE_CONFORMATION_PRPSC_TO_MGLUR5_CA2_APOPTOTIC_PATHWAY

RYR2 RYR3 ITPR3

3.91e-0519503M47760
PathwayREACTOME_ACTIVATION_OF_KAINATE_RECEPTORS_UPON_GLUTAMATE_BINDING

GRIK1 GRIK2 GRIK3

1.59e-0430503M18193
PathwayREACTOME_ACTIVATION_OF_KAINATE_RECEPTORS_UPON_GLUTAMATE_BINDING

GRIK1 GRIK2 GRIK3

1.94e-0432503MM15143
PathwayREACTOME_DNA_DAMAGE_RECOGNITION_IN_GG_NER

CUL4B CUL4A CETN2

3.25e-0438503M27592
PathwayREACTOME_DNA_DAMAGE_RECOGNITION_IN_GG_NER

CUL4B CUL4A CETN2

3.25e-0438503MM15301
PathwayREACTOME_FORMATION_OF_INCISION_COMPLEX_IN_GG_NER

CUL4B CUL4A CETN2

4.69e-0443503M1005
PathwayKEGG_NUCLEOTIDE_EXCISION_REPAIR

CUL4B CUL4A CETN2

5.02e-0444503M18937
PathwayWP_NUCLEOTIDE_EXCISION_REPAIR

CUL4B CUL4A CETN2

5.02e-0444503M39847
PathwayKEGG_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION

ABAT ACADSB HADHA

5.02e-0444503M11835
PathwayREACTOME_FORMATION_OF_INCISION_COMPLEX_IN_GG_NER

CUL4B CUL4A CETN2

5.36e-0445503MM15302
PathwayKEGG_MEDICUS_REFERENCE_ISOLEUCINE_DEGRADATION

ACADSB HADHA

5.45e-0410502M47635
PathwayKEGG_MEDICUS_REFERENCE_BETA_OXIDATION

ACADSB HADHA

6.64e-0411502M47630
PathwayKEGG_MEDICUS_REFERENCE_CA2_CAM_VGCC_RYR_SIGNALING_PATHWAY

RYR2 RYR3

6.64e-0411502M47958
PathwayWP_DNA_REPAIR_PATHWAYS_FULL_NETWORK

CUL4B CUL4A LIG4 CETN2

8.50e-04120504M40049
PathwayREACTOME_ION_HOMEOSTASIS

RYR2 RYR3 ITPR3

9.17e-0454503M27460
PathwayREACTOME_ION_HOMEOSTASIS

RYR2 RYR3 ITPR3

9.17e-0454503MM15202
PathwayWP_CELLTYPE_DEPENDENT_SELECTIVITY_OF_CCK2R_SIGNALING

RYR2 RYR3

9.38e-0413502M39589
PathwayWP_MFAP5MEDIATED_OVARIAN_CANCER_CELL_MOTILITY_AND_INVASIVENESS

RYR3 ITPR3

9.38e-0413502M39463
PathwayBIOCARTA_BCELLSURVIVAL_PATHWAY

PIK3CG XIAP

1.26e-0315502M4835
Pubmed

Kainate receptor-mediated responses in the CA1 field of wild-type and GluR6-deficient mice.

GRIK1 GRIK2 GRIK3

5.66e-0936339880586
Pubmed

The kainate receptor antagonist UBP310 but not single deletion of GluK1, GluK2, or GluK3 subunits, inhibits MPTP-induced degeneration in the mouse midbrain.

GRIK1 GRIK2 GRIK3

5.66e-09363331513786
Pubmed

Differential trafficking of GluR7 kainate receptor subunit splice variants.

GRIK1 GRIK2 GRIK3

5.66e-09363315805114
Pubmed

Kainate receptors and rhythmic activity in neuronal networks: hippocampal gamma oscillations as a tool.

GRIK1 GRIK2 GRIK3

2.26e-08463315513934
Pubmed

Reduced synaptic function of Kainate receptors in the insular cortex of Fmr1 Knock-out mice.

GRIK1 GRIK2 GRIK3

2.26e-08463330241548
Pubmed

Kainate receptors act as conditional amplifiers of spike transmission at hippocampal mossy fiber synapses.

GRIK1 GRIK2 GRIK3

2.26e-08463319369569
Pubmed

Developmental expression patterns of kainate receptors in the mouse spinal cord.

GRIK1 GRIK2 GRIK3

5.65e-08563323076118
Pubmed

Complete Disruption of the Kainate Receptor Gene Family Results in Corticostriatal Dysfunction in Mice.

GRIK1 GRIK2 GRIK3

5.65e-08563328228252
Pubmed

Development of laminar distributions of kainate receptors in the somatosensory cortex of mice.

GRIK1 GRIK2 GRIK3

5.65e-0856339593973
Pubmed

Kainate receptors: pharmacology, function and therapeutic potential.

GRIK1 GRIK2 GRIK3

5.65e-08563318793656
Pubmed

Kainate receptor subunits underlying presynaptic regulation of transmitter release in the dorsal horn.

GRIK1 GRIK2 GRIK3

5.65e-08563312223554
Pubmed

Molecular determinants of kainate receptor trafficking.

GRIK1 GRIK2 GRIK3

5.65e-08563318358623
Pubmed

Preferential assembly of heteromeric kainate and AMPA receptor amino terminal domains.

GRIK1 GRIK2 GRIK3

5.65e-08563329058671
Pubmed

Chromosomal localization of glutamate receptor genes: relationship to familial amyotrophic lateral sclerosis and other neurological disorders of mice and humans.

SPTAN1 GRIK1 GRIK2 GRIK3

8.43e-08236348464923
Pubmed

Roles of I(f) and intracellular Ca2+ release in spontaneous activity of ventricular cardiomyocytes during murine embryonic development.

RYR2 RYR3 ITPR3

1.13e-07663323463619
Pubmed

A calcium-induced calcium release mechanism supports luteinizing hormone-induced testosterone secretion in mouse Leydig cells.

RYR2 RYR3 ITPR3

1.13e-07663320519450
Pubmed

Essential Roles of Intracellular Calcium Release Channels in Muscle, Brain, Metabolism, and Aging.

RYR2 RYR3 ITPR3

1.13e-07663325966694
Pubmed

N-glycan content modulates kainate receptor functional properties.

GRIK1 GRIK2 GRIK3

1.13e-07663328714086
Pubmed

IP3Rs are sufficient for dendritic cell Ca2+ signaling in the absence of RyR1.

RYR2 RYR3 ITPR3

1.13e-07663316844763
Pubmed

Short-term plasticity of kainate receptor-mediated EPSCs induced by NMDA receptors at hippocampal mossy fiber synapses.

GRIK1 GRIK2 GRIK3

1.97e-07763317428973
Pubmed

Glutamate receptors in cortical plasticity: molecular and cellular biology.

GRIK1 GRIK2 GRIK3

1.97e-0776339016303
Pubmed

Glutamate binding and conformational flexibility of ligand-binding domains are critical early determinants of efficient kainate receptor biogenesis.

GRIK1 GRIK2 GRIK3

1.97e-07763319342380
Pubmed

Glutamate receptors: brain function and signal transduction.

GRIK1 GRIK2 GRIK3

1.97e-0776339651535
Pubmed

Developmental expression of the calcium release channels during early neurogenesis of the mouse cerebral cortex.

RYR2 RYR3 ITPR3

1.97e-07763311860456
Pubmed

Primary structure and expression of the gamma 2 subunit of the glutamate receptor channel selective for kainate.

GRIK1 GRIK2 GRIK3

1.97e-0776331310861
Pubmed

Roles of IP3R and RyR Ca2+ channels in endoplasmic reticulum stress and beta-cell death.

RYR2 RYR3 ITPR3

3.15e-07863319033399
Pubmed

Transmembrane topology of the glutamate receptor subunit GluR6.

GRIK1 GRIK2 GRIK3

3.15e-0786338163463
Pubmed

Expression of glutamate receptor subunit genes during development of the mouse retina.

GRIK1 GRIK2 GRIK3

4.72e-0796339051806
Pubmed

KEAP1 Mutations Drive Tumorigenesis by Suppressing SOX9 Ubiquitination and Degradation.

CUL4B CUL4A KLHL3

1.23e-061263333173725
Pubmed

Glutamatergic gene variants impact the clinical profile of efficacy and side effects of haloperidol.

GRIK1 GRIK2 GRIK3

1.60e-061363320859245
Pubmed

Presynaptic kainate receptors impart an associative property to hippocampal mossy fiber long-term potentiation.

GRIK1 GRIK2

3.23e-06263212947409
Pubmed

Altered behavioral responses to noxious stimuli and fear in glutamate receptor 5 (GluR5)- or GluR6-deficient mice.

GRIK1 GRIK2

3.23e-06263215673679
Pubmed

Association of markers in the 3' region of the GluR5 kainate receptor subunit gene to alcohol dependence.

GRIK1 GRIK3

3.23e-06263219320626
Pubmed

Kainate receptors are involved in short- and long-term plasticity at mossy fiber synapses in the hippocampus.

GRIK1 GRIK2

3.23e-06263211182092
Pubmed

Kainate receptor-mediated synaptic transmission in the adult anterior cingulate cortex.

GRIK1 GRIK2

3.23e-06263215928066
Pubmed

Altered ryanodine receptor expression in mild cognitive impairment and Alzheimer's disease.

RYR2 RYR3

3.23e-06263221531043
Pubmed

Modulation of calcium signalling by dominant negative splice variant of ryanodine receptor subtype 3 in native smooth muscle cells.

RYR2 RYR3

3.23e-06263216678258
Pubmed

Modulation of excitatory synaptic transmission in the spinal substantia gelatinosa of mice deficient in the kainate receptor GluR5 and/or GluR6 subunit.

GRIK1 GRIK2

3.23e-06263214724198
Pubmed

GluR7 is an essential subunit of presynaptic kainate autoreceptors at hippocampal mossy fiber synapses.

GRIK2 GRIK3

3.23e-06263217620617
Pubmed

Q/R site editing in kainate receptor GluR5 and GluR6 pre-mRNAs requires distant intronic sequences.

GRIK1 GRIK2

3.23e-0626328700852
Pubmed

The kainate receptor subunit GluR6 mediates metabotropic regulation of the slow and medium AHP currents in mouse hippocampal neurones.

GRIK1 GRIK2

3.23e-06263215539395
Pubmed

Mutations in Cullin 4B result in a human syndrome associated with increased camptothecin-induced topoisomerase I-dependent DNA breaks.

CUL4B CUL4A

3.23e-06263220064923
Pubmed

Dysregulation of CUL4A and CUL4B Ubiquitin Ligases in Lung Cancer.

CUL4B CUL4A

3.23e-06263227974468
Pubmed

RNA editing of human kainate receptor subunits.

GRIK1 GRIK2

3.23e-0626327696618
Pubmed

Atypical functional properties of GluK3-containing kainate receptors.

GRIK2 GRIK3

3.23e-06263220007474
Pubmed

Q/R site editing controls kainate receptor inhibition by membrane fatty acids.

GRIK1 GRIK2

3.23e-06263216221857
Pubmed

Altered long-term synaptic plasticity and kainate-induced Ca2+ transients in the substantia gelatinosa neurons in GLU(K6)-deficient mice.

GRIK1 GRIK2

3.23e-06263216219388
Pubmed

Expression and novel subunit isoforms of glutamate receptor genes GluR5 and GluR6.

GRIK1 GRIK2

3.23e-0626328260617
Pubmed

Regulatory mechanisms and pathophysiological significance of IP3 receptors and ryanodine receptors in drug dependence.

RYR2 ITPR3

3.23e-06263224285081
Pubmed

Subunit composition and alternative splicing regulate membrane delivery of kainate receptors.

GRIK1 GRIK2

3.23e-06263215014126
Pubmed

Tissue-specific alternative splicing of mouse brain type ryanodine receptor/calcium release channel mRNA.

RYR2 RYR3

3.23e-0626328898078
Pubmed

Assessing the role of GLUK5 and GLUK6 at hippocampal mossy fiber synapses.

GRIK1 GRIK2

3.23e-06263215537878
Pubmed

Subunit composition of kainate receptors in hippocampal interneurons.

GRIK1 GRIK2

3.23e-06263211144357
Pubmed

Wide long lasting perinuclear Ca2+ release events generated by an interaction between ryanodine and IP3 receptors in canine Purkinje cells.

RYR2 ITPR3

3.23e-06263218586264
Pubmed

Contribution of aberrant GluK2-containing kainate receptors to chronic seizures in temporal lobe epilepsy.

GRIK1 GRIK2

3.23e-06263225043179
Pubmed

Frequency and transmission of glutamate receptors GRIK2 and GRIK3 polymorphisms in patients with obsessive compulsive disorder.

GRIK2 GRIK3

3.23e-06263215094479
Pubmed

The mouse sino-atrial node expresses both the type 2 and type 3 Ca(2+) release channels/ryanodine receptors.

RYR2 RYR3

3.23e-06263214550562
Pubmed

Postnatal maturation of mossy fibre excitatory transmission in mouse CA3 pyramidal cells: a potential role for kainate receptors.

GRIK1 GRIK2

3.23e-06263215358807
Pubmed

Role of GluK1 kainate receptors in seizures, epileptic discharges, and epileptogenesis.

GRIK1 GRIK2

3.23e-06263224760837
Pubmed

A mosaic of functional kainate receptors in hippocampal interneurons.

GRIK1 GRIK2

3.23e-06263215483117
Pubmed

Functional characterization of kainate receptors in the mouse nucleus accumbens.

GRIK1 GRIK2

3.23e-06263211985817
Pubmed

Decreased expression of ryanodine receptors alters calcium-induced calcium release mechanism in mdx duodenal myocytes.

RYR2 RYR3

3.23e-06263214985349
Pubmed

Identification of the kainate receptor subunits underlying modulation of excitatory synaptic transmission in the CA3 region of the hippocampus.

GRIK1 GRIK2

3.23e-06263211069933
Pubmed

Type 1 and type 3 ryanodine receptors are selectively involved in muscarinic antinociception in mice: an antisense study.

RYR2 RYR3

9.68e-06363218403125
Pubmed

Distinct roles for the kainate receptor subunits GluR5 and GluR6 in kainate-induced hippocampal gamma oscillations.

GRIK1 GRIK2

9.68e-06363215509753
Pubmed

Heterogeneous gene expression and functional activity of ryanodine receptors in resistance and conduit pulmonary as well as mesenteric artery smooth muscle cells.

RYR2 RYR3

9.68e-06363218434746
Pubmed

CUL4high Lung Adenocarcinomas Are Dependent on the CUL4-p21 Ubiquitin Signaling for Proliferation and Survival.

CUL4B CUL4A

9.68e-06363234119472
Pubmed

Control of Neuronal Ryanodine Receptor-Mediated Calcium Signaling by Calsenilin.

RYR2 RYR3

9.68e-06363229730765
Pubmed

SPRY domains in ryanodine receptors (Ca(2+)-release channels).

RYR2 RYR3

9.68e-0636329204703
Pubmed

Distinct Subunit Domains Govern Synaptic Stability and Specificity of the Kainate Receptor.

GRIK1 GRIK2

9.68e-06363227346345
Pubmed

Cloning and functional expression of a cDNA encoding the mouse beta 2 subunit of the kainate-selective glutamate receptor channel.

GRIK1 GRIK2

9.68e-0636321379666
Pubmed

The ryanodine receptor/calcium channel genes are widely and differentially expressed in murine brain and peripheral tissues.

RYR2 RYR3

9.68e-0636327876312
Pubmed

Effect of RNA editing and subunit co-assembly single-channel properties of recombinant kainate receptors.

GRIK1 GRIK2

9.68e-0636328730589
Pubmed

Ryanodine receptors are expressed in epidermal keratinocytes and associated with keratinocyte differentiation and epidermal permeability barrier homeostasis.

RYR2 RYR3

9.68e-06363221881589
Pubmed

Isoform-dependent formation of heteromeric Ca2+ release channels (ryanodine receptors).

RYR2 RYR3

9.68e-06363212213830
Pubmed

CUL4 E3 ligase regulates the proliferation and apoptosis of lung squamous cell carcinoma and small cell lung carcinoma.

CUL4B CUL4A

9.68e-06363232587774
Pubmed

Expression of the ryanodine receptor type 3 calcium release channel during development and differentiation of mammalian skeletal muscle cells.

RYR2 RYR3

9.68e-0636329242641
Pubmed

Bidirectional coupling between ryanodine receptors and Ca2+ release-activated Ca2+ (CRAC) channel machinery sustains store-operated Ca2+ entry in human T lymphocytes.

RYR2 RYR3

9.68e-06363222948152
Pubmed

Cullin4B/E3-ubiquitin ligase negatively regulates beta-catenin.

CUL4B CUL4A

9.68e-06363217954973
Pubmed

Developmental changes in expression of the three ryanodine receptor mRNAs in the mouse brain.

RYR2 RYR3

9.68e-06363210788707
Pubmed

RYR2 proteins contribute to the formation of Ca(2+) sparks in smooth muscle.

RYR2 RYR3

9.68e-06363215024040
Pubmed

Seizure protein 6 controls glycosylation and trafficking of kainate receptor subunits GluK2 and GluK3.

GRIK2 GRIK3

9.68e-06363232567721
Pubmed

Changes in expression of glutamate receptor subunits following photoreceptor degeneration in the rd mouse retina.

GRIK1 GRIK3

9.68e-0636327538211
Pubmed

Calcineurin upregulates local Ca(2+) signaling through ryanodine receptor-1 in airway smooth muscle cells.

RYR2 RYR3

9.68e-06363225239916
Pubmed

Ca(2+)-induced Ca2+ release in myocytes from dyspedic mice lacking the type-1 ryanodine receptor.

RYR2 RYR3

9.68e-0636327621815
Pubmed

A gene-specific cerebral types 1, 2, and 3 RyR protein knockdown induces an antidepressant-like effect in mice.

RYR2 RYR3

9.68e-06363218643873
Pubmed

Identification of mutations in the cardiac ryanodine receptor gene in families affected with arrhythmogenic right ventricular cardiomyopathy type 2 (ARVD2).

RYR2 RYR3

9.68e-06363211159936
Pubmed

E3 ubiquitin ligase Cullin4B mediated polyubiquitination of p53 for its degradation.

CUL4B CUL4A

9.68e-06363224452595
Pubmed

Molecular identification of the ryanodine receptor pore-forming segment.

RYR2 RYR3

9.68e-06363210473538
Pubmed

RNA editing of the glutamate receptor subunits GluR2 and GluR6 in human brain tissue.

GRIK1 GRIK2

9.68e-0636327523595
Pubmed

Chromosomal localization of murine ryanodine receptor genes RYR1, RYR2, and RYR3 by in situ hybridization.

RYR2 RYR3

9.68e-0636327959768
Pubmed

The organization of proteins in the human red blood cell membrane. A review.

RYR2 RYR3

9.68e-0636324600883
Pubmed

Regulation of mouse egg activation: presence of ryanodine receptors and effects of microinjected ryanodine and cyclic ADP ribose on uninseminated and inseminated eggs.

RYR2 RYR3

9.68e-0636327635066
Pubmed

Glutamate can act as a signaling molecule in mouse preimplantation embryos†.

GRIK1 GRIK2 GRIK3

1.12e-052463335746896
Pubmed

Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.

TXLNA ACADSB HSDL2 SYNE1 SPTAN1 UGGT1 RRP12 CLTC HADHA DZIP1 YME1L1 ITPR3

1.26e-051487631233957083
Pubmed

A High-Density Human Mitochondrial Proximity Interaction Network.

STRN3 ACADSB HSDL2 SYNE1 KIAA1217 RRP12 CLTC LRP2 XIAP HADHA YME1L1 ITPR3

1.34e-051496631232877691
Pubmed

LncRNAs-directed PTEN enzymatic switch governs epithelial-mesenchymal transition.

FSIP2 TOPAZ1 SYNE1 RYR2 RYR3

1.39e-0516863530631154
Pubmed

Characterization of the binding sites for the interactions between FKBP12 and intracellular calcium release channels.

RYR3 ITPR3

1.93e-05463222100703
Pubmed

Genetic evidence for the requirement of adenylyl cyclase 1 in synaptic scaling of forebrain cortical neurons.

GRIK1 GRIK2

1.93e-05463217650106
Pubmed

The auxiliary subunits Neto1 and Neto2 have distinct, subunit-dependent effects at recombinant GluK1- and GluK2-containing kainate receptors.

GRIK1 GRIK2

1.93e-05463226277340
InteractionGRIK4 interactions

GRIK1 GRIK2 GRIK3

1.46e-068613int:GRIK4
InteractionGRIK3 interactions

GRIK1 GRIK2 GRIK3

3.12e-0610613int:GRIK3
InteractionDCAF12L2 interactions

CUL4B CUL4A CETN2

9.38e-0614613int:DCAF12L2
InteractionCEP63 interactions

CWF19L2 TXLNA TXLNB SYNE1 SPTAN1 TEX9

1.67e-05179616int:CEP63
InteractionPTEN interactions

CUL4B CUL4A FSIP2 HSDL2 TOPAZ1 SPTAN1 UGGT1 XIAP HADHA YME1L1 RYR3 ITPR3

1.85e-059296112int:PTEN
InteractionGRIK5 interactions

GRIK1 GRIK2 GRIK3

2.90e-0520613int:GRIK5
InteractionCOMMD1 interactions

CUL4B CUL4A LIG4 CWF19L2 XIAP

3.53e-05123615int:COMMD1
InteractionATG16L1 interactions

CWF19L2 TXLNA TXLNB APPL2 KIAA1217 RRP12 CLTC AKAP10 TEX9 YME1L1 RYR2 CENPQ ITPR3

3.55e-0511616113int:ATG16L1
InteractionSIKE1 interactions

STRN3 TXLNA TXLNB CENPQ

4.48e-0565614int:SIKE1
InteractionRYR3 interactions

UGGT1 RYR2 RYR3

5.10e-0524613int:RYR3
InteractionCCDC112 interactions

TXLNA SPTAN1 TEX9

9.12e-0529613int:CCDC112
InteractionUSP19 interactions

CUL4B CUL4A PPP2R5B ACADSB XIAP

1.03e-04154615int:USP19
InteractionCFAP53 interactions

CWF19L2 TXLNA TXLNB

1.12e-0431613int:CFAP53
InteractionGRIK2 interactions

GRIK1 GRIK2 GRIK3

1.23e-0432613int:GRIK2
InteractionFBF1 interactions

CUL4B TXLNA ACADSB GPATCH1 CLTC

1.68e-04171615int:FBF1
InteractionGRIK1 interactions

GRIK1 GRIK2 GRIK3

1.75e-0436613int:GRIK1
GeneFamilyGlutamate ionotropic receptor kainate type subunits

GRIK1 GRIK2 GRIK3

1.16e-0754231199
GeneFamilyRyanodine receptors|Protein phosphatase 1 regulatory subunits

RYR2 RYR3

1.58e-053422287
GeneFamilyCullins

CUL4B CUL4A

1.46e-0484221032
GeneFamilyWD repeat domain containing|Protein phosphatase 2 regulatory subunits

STRN3 PPP2R5B

5.43e-0415422696
GeneFamilyLipases|Arylacetamide deacetylase family

LIPC LIPI

1.18e-0322422464
GeneFamilyEF-hand domain containing

CETN2 SPTAN1 RYR2 RYR3

1.63e-03219424863
CoexpressionGSE14000_UNSTIM_VS_16H_LPS_DC_TRANSLATED_RNA_UP

ABAT ACADSB UGGT1 LRRC8A HADHA EPAS1

7.95e-06197636M3343
CoexpressionGSE12392_WT_VS_IFNB_KO_CD8A_NEG_SPLEEN_DC_DN

APPL2 PIK3CG XIAP AKAP10 TEX9 ARAP2

8.66e-06200636M7150
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MGAM LRP2 GRIK3 CSMD3 RYR2 RYR3

2.41e-07184636ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MGAM LRP2 GRIK3 CSMD3 RYR2 RYR3

2.41e-071846362cbed6462fea2622871bb7e49b0df3d984239281
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MGAM LRP2 GRIK3 CSMD3 RYR2 RYR3

2.41e-071846362b19a8c5f823e00812908b23e66bb4e563278aff
ToppCellCOVID-19-Heart-Neuronal|Heart / Disease (COVID-19 only), tissue and cell type

NEUROD4 KIAA1217 GRIK2 GRIK3 ARAP2

4.65e-061736356fb5f9e6536a5d57fd8e6657b494047a2d0bc9c7
ToppCellTCGA-Brain-Primary_Tumor-Low_Grade_Glioma|TCGA-Brain / Sample_Type by Project: Shred V9

ACADSB SYNE1 SPTAN1 LRRC8A CSMD3

5.20e-06177635e8ab340b20cd41554c3841fe980e078e878af35f
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

LIPC KIAA1217 GRIK1 GRIK2 GRIK3

6.80e-0618763585f1678338a47d91e296f0620d4887f057eb7e70
ToppCell-Unknown-Endothelial-Myofibroblast| / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

STRN3 HSDL2 AKAP10 CARNMT1 RYR2

6.97e-061886356468fa95ad0395395301115286f2d8c0df5d3882
ToppCell-Unknown-Endothelial| / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

STRN3 HSDL2 AKAP10 CARNMT1 RYR2

6.97e-061886357a81ac5c79c3eb26639b52d2b9fd5e7ef9798fd6
ToppCell-Unknown| / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

STRN3 HSDL2 AKAP10 CARNMT1 RYR2

6.97e-061886359cb718bfe1358c6fd842f096e228eb0abb9aefc6
ToppCellNeuronal-Inhibitory-iB-iB_4(SST)-B3GAT2|Neuronal / cells hierarchy compared to all cells using T-Statistic

LIPC KIAA1217 GRIK1 GRIK2 GRIK3

9.41e-06200635858421b91f5207b7934b5c219752cb9322a3da31
ToppCellNeuronal-Inhibitory-iB-iB_4(SST)-STK32A|Neuronal / cells hierarchy compared to all cells using T-Statistic

LIPC KIAA1217 GRIK1 GRIK2 GRIK3

9.41e-062006358d51b4f7b7002ee51401ebe5eaca1e8f04bfadd5
ToppCellNeuronal-Inhibitory-iB-iB_3(PVALB-SST)|Neuronal / cells hierarchy compared to all cells using T-Statistic

LIPC KIAA1217 GRIK1 GRIK2 GRIK3

9.41e-06200635107854f4855fc99c9f7e737eb246f0d868e6c5fd
ToppCellMacroglial-Polydendrocytes-PDGFRA---|Macroglial / cells hierarchy compared to all cells using T-Statistic

KIAA1217 GRIK1 GRIK2 GRIK3 CSMD3

9.41e-062006354fc3de4bff7ed2bf40b38462c4b4e9b87af6a4ca
ToppCellMacroglial-Polydendrocytes-PDGFRA-|Macroglial / cells hierarchy compared to all cells using T-Statistic

KIAA1217 GRIK1 GRIK2 GRIK3 CSMD3

9.41e-06200635f17b5a54e8f9eba9dcd0808ba4e8d275ac41bce2
ToppCellMacroglial-Polydendrocytes-PDGFRA--|Macroglial / cells hierarchy compared to all cells using T-Statistic

KIAA1217 GRIK1 GRIK2 GRIK3 CSMD3

9.41e-06200635cc3409518f8b436ea92deb955e81114b3f410ff7
ToppCellNeuronal-Inhibitory-iB-iB_4(SST)-STK32A-|Neuronal / cells hierarchy compared to all cells using T-Statistic

LIPC KIAA1217 GRIK1 GRIK2 GRIK3

9.41e-062006356a44439e4a7ce3627271375b04cfcfb9467218f4
ToppCellNeuronal-Inhibitory-iB-iB_4(SST)-STK32A--L4-5|Neuronal / cells hierarchy compared to all cells using T-Statistic

LIPC KIAA1217 GRIK1 GRIK2 GRIK3

9.41e-06200635cb1f4b0d66da5b0466ff17b29e7034d451d93e4f
ToppCellMacroglial-Polydendrocytes-PDGFRA----L1-6|Macroglial / cells hierarchy compared to all cells using T-Statistic

KIAA1217 GRIK1 GRIK2 GRIK3 CSMD3

9.41e-06200635310cd53db1c137f6af74e6ae682221d7ac27310c
ToppCellMacroglial-Polydendrocytes-PDGFRA|Macroglial / cells hierarchy compared to all cells using T-Statistic

KIAA1217 GRIK1 GRIK2 GRIK3 CSMD3

9.41e-06200635c24a3099e3d96d8b72f6d05286bb355d661a0377
ToppCellNeuronal-Inhibitory-iB-iB_4(SST)-B3GAT2-|Neuronal / cells hierarchy compared to all cells using T-Statistic

LIPC KIAA1217 GRIK1 GRIK2 GRIK3

9.41e-06200635a7022762c1d8aedb7b3e9605873b1e68b9907b35
ToppCellNeuronal-Inhibitory-iB-iB_4(SST)-B3GAT2--L4-6|Neuronal / cells hierarchy compared to all cells using T-Statistic

LIPC KIAA1217 GRIK1 GRIK2 GRIK3

9.41e-062006352131c8e7fa054b79906eaf60536da892438b09cd
ToppCellMacroglial-Polydendrocytes|Macroglial / cells hierarchy compared to all cells using T-Statistic

KIAA1217 GRIK1 GRIK2 GRIK3 CSMD3

9.41e-06200635961858738ce35db8760c8c2e136f8369bc444ccf
ToppCellfacs-Marrow-B-cells-24m-Lymphocytic-precursor_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LRP2 GRIK2 RYR2 RYR3

7.79e-05160634c381ec6be8cf887861cc18f831a20db42f953fe1
ToppCellfacs-Marrow-B-cells-24m-Lymphocytic-pre_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LRP2 GRIK2 RYR2 RYR3

7.79e-0516063425c8f3d2a6d14ff0ca0b965fce89d3ff22f40585
ToppCellfacs-Heart-LV-3m-Mesenchymal-atrial_myocyte|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MGAM TXLNB CSMD3 CENPQ

8.78e-05165634af59a095ecc6758abc13d763c00e44447c488167
ToppCellfacs-Heart-LV-3m-Mesenchymal-atrial_cardiomyocyte|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MGAM TXLNB CSMD3 CENPQ

8.78e-0516563484eca6a0f5e996b6955ae79fa102af239098fe8f
ToppCellLV-16._Neuronal|World / Chamber and Cluster_Paper

KIAA1217 GRIK2 GRIK3 ARAP2

8.78e-051656346ed52cb756d21addf46c7f6c457458b01339fe04
ToppCellfacs-Brain_Non-Myeloid-Cerebellum-3m-Epithelial-neuronal_stem_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KLHL3 GPATCH1 GRIK3 DZIP1

8.78e-051656341703d3eb644b3c743ad3c5532b1d29ea010c79c8
ToppCellLA-16._Neuronal|World / Chamber and Cluster_Paper

KIAA1217 GRIK2 GRIK3 ARAP2

9.41e-051686342fd1fd2a16ac1c5eb028f93cc3a2477c7747693e
ToppCellLA-16._Neuronal|LA / Chamber and Cluster_Paper

KIAA1217 GRIK2 GRIK3 ARAP2

9.41e-05168634c55bbfbde8bb954f1cb9af82007bdd1f8070fee3
ToppCellCOVID-19_Mild-PLT_2|World / Disease Group and Platelet Clusters

ARHGAP42 TBC1D32 TOPAZ1 CARNMT1

9.63e-051696346abfdc8b437f19c03b408bedc245059d28c6ba6a
ToppCellLV-16._Neuronal|LV / Chamber and Cluster_Paper

KIAA1217 GRIK2 GRIK3 ARAP2

9.63e-05169634a8fc8ab0f0757e939e213efb61c03cfe390bf7d2
ToppCellfacs-Diaphragm-Limb_Muscle-24m|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LRP2 CSMD3 RYR2 RYR3

9.63e-0516963412bdc709bc000d7f9061ecd9fbd57233eaacb7e2
ToppCelldroplet-Lung-nan-21m-Myeloid-dendritic_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TXLNB GPR33 ZNF471 RYR3

1.01e-04171634159ce6d5513008532dd7785b915b3fe7440cc4b2
ToppCellTCGA-Brain-Primary_Tumor|TCGA-Brain / Sample_Type by Project: Shred V9

ARHGAP42 ABAT APPL2 LRRC8A

1.05e-04173634f6ba22661e67c17d49d1058d4170ba8f36bf47f0
ToppCellfacs-Diaphragm-Limb_Muscle-24m-Mesenchymal|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LRP2 CSMD3 RYR2 RYR3

1.05e-0417363466f37c1437705734b20601656fa4aa1d92ca30be
ToppCellfacs-Diaphragm-Limb_Muscle-24m-Mesenchymal-nan|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LRP2 CSMD3 RYR2 RYR3

1.05e-04173634649b08a409095592cccf31883be69c754411280d
ToppCellfacs-Diaphragm-Limb_Muscle-24m-Mesenchymal-skeletal_muscle_satellite_cell|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GLB1L3 LRP2 CSMD3 RYR3

1.08e-04174634f230d23618a6487f2664efb2c677e0a4559e2bf4
ToppCellfacs-Marrow-B-cells-24m|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LRP2 GRIK2 CSMD3 RYR2

1.10e-04175634887e75fc90e59a6394d62f3c048a9cfdf6707725
ToppCellPCW_05-06-Neuronal-Neuronal_SCP-neuro_pre_proliferating_SCP_(4)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

LRP2 GRIK2 GRIK3 ARAP2

1.15e-0417763459726bfd98f656fdcedf448a7e2e76a9bfad8285
ToppCellRA-16._Neuronal|RA / Chamber and Cluster_Paper

KIAA1217 GRIK2 GRIK3 ARAP2

1.23e-041806345842febfdabac61ce970254fb0ef17a628f1b8c0
ToppCellAT2_cells-Myositis-ILD_01|World / lung cells shred on cell class, cell subclass, sample id

LIPC ACADSB SYNE1 ITPR3

1.25e-04181634ed0ea67f0607073aedf153f8d1073b35e46127c3
ToppCellRA-16._Neuronal|World / Chamber and Cluster_Paper

KIAA1217 GRIK2 GRIK3 ARAP2

1.25e-041816347d22a43f887e0747f0cb87ba364ff27905ee6eec
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L5_PVALB_CNTNAP3P2|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ARHGAP42 KIAA1217 GRIK1 GRIK3

1.31e-04183634121791ef84e7ce377ed6f5b7953af8865e04958e
ToppCellPCW_05-06-Epithelial-Epithelial_alveolar-distal-epi_SOX9^high_Etv5^high_distal_(10)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

GBP6 NEUROD4 LRP2 ITPR3

1.34e-04184634fa4915b0498f3069fd5ef497286445528f75187e
ToppCelldroplet-Pancreas-Endocrine-18m-Endothelial-nan|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GBP6 TTC12 LRRC8A EPAS1

1.36e-04185634512a195ebbae445afe3722a3943020080daf2f3c
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST-Inh_L5-6_SST_ISOC1|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

LIPC KIAA1217 GRIK1 GRIK2

1.36e-04185634ae53aa2ecfe418a5dbd7d963a995bc06dab94f56
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L5_PVALB_CNTNAP3P2|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ARHGAP42 KIAA1217 GRIK1 GRIK3

1.42e-04187634d413fb4b1531b297af5012a392b88128510c2de8
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST-Inh_L2-4_SST_AHR|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ARHGAP42 KIAA1217 GRIK1 GRIK3

1.42e-0418763401393f6d1983eb4a2bcc80252012f77892851679
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L1_LAMP5_NDNF|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ARHGAP42 GRIK1 GRIK2 DNAH14

1.48e-04189634f0aaf2994d319a39877d2845eaab9f166adead4e
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_3|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ARHGAP42 KIAA1217 GRIK1 GRIK3

1.51e-04190634d19bc44310c53726e2f5f6a2bd377bbbf1d1983f
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST-Inh_L2-4_SST_AHR|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ARHGAP42 KIAA1217 GRIK1 GRIK3

1.54e-04191634782bc7946417549ffd39e5b596db659436fa01ba
ToppCellfacs-Lung-Endomucin_-18m|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SYNE1 LRRC8A EPAS1 ARAP2

1.57e-04192634ba3fe97786564dba1c8185f2802ce1b57f4f3cc9
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

KIAA1217 GRIK1 GRIK2 GRIK3

1.57e-04192634dc40ef2341e5d6a6d479f140e023fe1bf687928d
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L5_PVALB_CNTNAP3P2|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ARHGAP42 KIAA1217 GRIK1 GRIK3

1.57e-041926340003d7ef9a8e521e70ac33c63aad843d9b6215c2
ToppCellfacs-Lung-Endomucin_|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SYNE1 LRRC8A EPAS1 ARAP2

1.57e-0419263485d4d0df701451daf95e94a87a0096da1e86533b
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST-Inh_L3-5_SST_MAFB|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

KIAA1217 GRIK1 GRIK2 GRIK3

1.60e-04193634c7e9e6e4bf5e07c9cbdf1aa7c8828f4b2500e3ff
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

KIAA1217 GRIK1 GRIK2 GRIK3

1.60e-04193634d1445b8bf2bab36e1a326ddb2a528151db016c7d
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST-Inh_L4-6_SST_MTHFD2P6|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

KIAA1217 GRIK1 GRIK2 GRIK3

1.60e-041936348b77625bf3c87d39767fb391d1beaca4ab02342b
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

KIAA1217 GRIK1 GRIK2 GRIK3

1.60e-04193634010717ca052b6c8a525a43aaeffddea0d1113e63
ToppCellfacs-Lung-Endomucin_-18m-Endothelial-endothelial_cell_of_lung|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SYNE1 LRRC8A EPAS1 ARAP2

1.60e-041936342218833749576ba1a0fc95bd155c781e7e1163c6
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

KIAA1217 GRIK1 GRIK2 GRIK3

1.60e-041936343ed46f5a7419ec4eddbd0df0d9b5f53aa486198b
ToppCellTCGA-Prostate-Primary_Tumor-Prostate_Adenocarcinoma-Acinar_Adenocarcinoma-6|TCGA-Prostate / Sample_Type by Project: Shred V9

CUL4B CLTC TRAPPC10 XIAP

1.60e-04193634abd71b2cf667ef2b1c4d88acd0c1dd19a12ff659
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

KIAA1217 GRIK1 GRIK2 GRIK3

1.60e-041936342189da4b727e25e62669d7b9257f06493be21a27
ToppCellEpithelial-club_cell|World / Lineage, Cell type, age group and donor

ARHGAP42 ACADSB KIAA1217 GRIK2

1.60e-041936342bdd09004fa433550958ec42ba4b06271a4aaf7c
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST-Inh_L3-5_SST_MAFB|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

KIAA1217 GRIK1 GRIK2 GRIK3

1.60e-04193634e74fdc8718fe0933e1f4dd3fe37e2134983b99b6
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST-Inh_L3-5_SST_MAFB|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

KIAA1217 GRIK1 GRIK2 GRIK3

1.60e-04193634658c2b30a4d806c5ce78ea4392fe8eb86b8d1e99
ToppCellCOVID-19-Endothelial_cells-Inflamed_endothelial_cells|COVID-19 / group, cell type (main and fine annotations)

SYNE1 KIAA1217 LRRC8A EPAS1

1.60e-04193634979ebefa527f86bebeea5d94e626ee6c1cc7d53b
ToppCellfacs-Lung-Endomucin_-18m-Endothelial|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SYNE1 LRRC8A EPAS1 ARAP2

1.64e-04194634df56e23f1dcf1902d29392fcc947e0e268e1648b
ToppCellLPS-antiTNF-Stromal_mesenchymal|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ARHGAP42 COL6A6 SYNE1 RYR2

1.64e-041946346e13549f697f7478b34fe71f7dd9d63c5d3db22e
ToppCellnucseq-Epithelial-Epithelial_Alveolar-Secretory/RAS-RAS|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

ARHGAP42 ACADSB KIAA1217 GRIK2

1.64e-04194634a58841b34efe673671a9a059238e044a7254b279
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST-Inh_L3-5_SST_MAFB|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

KIAA1217 GRIK1 GRIK2 GRIK3

1.64e-041946341bcb3fafd498614f7bac2b1c9b7de56e39110f65
ToppCellnucseq-Epithelial-Epithelial_Alveolar-Secretory/RAS|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

ARHGAP42 ACADSB KIAA1217 GRIK2

1.64e-041946340cd4363627acd419e00d6d32f6dce10430aa6487
ToppCellBronchial-NucSeq-Epithelial-Epi_airway_secretory-Secretory_Club|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

ARHGAP42 ACADSB CETN2 KIAA1217

1.70e-04196634ed76eeb37400ca154feae9b7ebaddb6c434f8b81
ToppCellMid-temporal_gyrus_(MTG)-Neuronal|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SYNE1 GRIK2 CSMD3 RYR2

1.70e-04196634676c56b44ac29f7baecb62f49bb8597cc74c0a88
ToppCellBronchial-NucSeq-Stromal-Schwann-Schwann_Myelinating|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

KLHL3 ABAT LIPC GRIK1

1.70e-04196634efeb272bc9e37e60d15d056b7574991c5c7501bc
ToppCell5'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.2.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

KIAA1217 SPTAN1 CLTC EPAS1

1.74e-041976345c4cee914baf7cb43e9cb99cc9e3ae823856dc15
ToppCellmild-low-quality_cells|mild / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

TBC1D32 CWF19L2 SYNE1 ARAP2

1.74e-04197634e4331969bd911d1ebb5453f40a7057297b5389b4
ToppCellSomatosensory_Cortex_(S1)-Neuronal|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SYNE1 GRIK2 CSMD3 RYR2

1.77e-04198634c01091ef18e096d792ea2a7a715764a5b215355f
ToppCellprimary_auditory_cortex_(A1C)-Neuronal|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SYNE1 GRIK2 CSMD3 RYR2

1.77e-041986346d18b45eda4014759e6dd282d78ffd28df8a6044
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SYNE1 SPTAN1 CSMD3 RYR2

1.77e-041986348ab40fae14fe02e39bc8c8da187a5cd60c787643
ToppCellControl_saline-Mesenchymal_fibroblastic-Fibroblasts-Activated_MatrixFB|Control_saline / Treatment groups by lineage, cell group, cell type

TBC1D32 TXLNB RYR2 RYR3

1.77e-041986340c4d2c68a42f8a9e964e2dd28092fe75f5216834
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SYNE1 GRIK2 CSMD3 RYR2

1.77e-041986344ca5ff320905ab4ff60ed90a5522227c782142a6
ToppCellNeuronal-Inhibitory-iB-iB_4(SST)-ADGRG6-|Neuronal / cells hierarchy compared to all cells using T-Statistic

KIAA1217 GRIK1 GRIK2 GRIK3

1.84e-04200634a9cdddc4e985dae59521e557479c24fcc2ac727d
ToppCellNeuronal-Inhibitory-iB-iB_3(PVALB-SST)-FRZB|Neuronal / cells hierarchy compared to all cells using T-Statistic

ARHGAP42 KIAA1217 GRIK1 GRIK3

1.84e-04200634e79d93d55b25804f2608185168da472301b6ebca
ToppCellNeuronal-Inhibitory-iB-iB_4(SST)|Neuronal / cells hierarchy compared to all cells using T-Statistic

KIAA1217 GRIK1 GRIK2 GRIK3

1.84e-04200634347a510755374c6a66acee326565dfc447993f18
ToppCellNeuronal-Inhibitory-iB-iB_3(PVALB-SST)-NPM1P10--L5-6|Neuronal / cells hierarchy compared to all cells using T-Statistic

LIPC KIAA1217 GRIK1 GRIK2

1.84e-042006342ea33ac1970791e6a601ac1e407ef32e4833792d
ToppCellNeuronal-Inhibitory-iB-iB_4(SST)-GXYLT2-|Neuronal / cells hierarchy compared to all cells using T-Statistic

LIPC KIAA1217 GRIK1 GRIK2

1.84e-04200634fe63aa1febd2bf650a7dd4e8b4420063580644ba
ToppCellLPS_anti-TNF-Mesenchymal_myocytic|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

ARHGAP42 SYNE1 DZIP1 RYR2

1.84e-0420063467dcbd86fbc79fd585d0793f979e4aac100326c9
ToppCellControl_saline-Mesenchymal_myocytic-Myofibroblastic-Myofibroblast|Control_saline / Treatment groups by lineage, cell group, cell type

ARHGAP42 SYNE1 DZIP1 RYR2

1.84e-04200634c5e051f1aac8dda376c342a9932785a23450e073
ToppCellLPS_anti-TNF-Endothelial-Endothelial-Activated_Alv_Cap|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

KIAA1217 SPTAN1 LRRC8A EPAS1

1.84e-04200634bcd1cc96197929d6011903803b6f4ccdcf52b4ce
ToppCellBronchial-NucSeq-Epithelial-Epi_airway_basal|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

GLB1L3 KIAA1217 LRRC8A GRIK2

1.84e-042006348827653738a931e4a4545e0c7d75be12bed40740
ToppCellNeuronal-Inhibitory-iB-iB_4(SST)-KLHDC8A|Neuronal / cells hierarchy compared to all cells using T-Statistic

KIAA1217 GRIK1 GRIK2 GRIK3

1.84e-0420063405bcde6ce8f1354ef65e4eb9cbd963a92108081c
ToppCellControl_saline-Mesenchymal_myocytic-Pericyte|Control_saline / Treatment groups by lineage, cell group, cell type

ARHGAP42 COL6A6 DZIP1 RYR2

1.84e-04200634cb7ef774b6d300f8019c5b16a04e3ebd165e4f1c
ToppCellNeuronal-Inhibitory-iB-iB_4(SST)-ADGRG6--L3-5|Neuronal / cells hierarchy compared to all cells using T-Statistic

KIAA1217 GRIK1 GRIK2 GRIK3

1.84e-0420063433b9199e0dfc267e2cea20b82d1c167f8adcc635
ToppCellLPS_only-Endothelial-Endothelial-Activated_Alv_Cap|LPS_only / Treatment groups by lineage, cell group, cell type

GBP6 KIAA1217 SPTAN1 EPAS1

1.84e-04200634edb64556b3fefe3144f73b6efe23b9ffd34091d2
ToppCellControl_saline-Mesenchymal_myocytic-Myofibroblastic|Control_saline / Treatment groups by lineage, cell group, cell type

ARHGAP42 SYNE1 DZIP1 RYR2

1.84e-042006349d5b3c2dcfa55d50acc2ce2c319d51aa525d4cd1
ToppCellLPS_IL1RA_TNF-Endothelial-Endothelial-Activated_Gen_Cap|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

GBP6 KIAA1217 SPTAN1 EPAS1

1.84e-042006343585484c7e24e941708bee471ca607d8ccee74e6
ToppCellNeuronal-Inhibitory-iB-iB_4(SST)-GXYLT2|Neuronal / cells hierarchy compared to all cells using T-Statistic

LIPC KIAA1217 GRIK1 GRIK2

1.84e-0420063437728d83b246dd70933d1f52f938bc1c401df7b9
ToppCellNeuronal-Inhibitory-iB-iB_4(SST)-ADGRG6|Neuronal / cells hierarchy compared to all cells using T-Statistic

KIAA1217 GRIK1 GRIK2 GRIK3

1.84e-042006349719fabddc34051949468a7520289e3c750de4f8
ComputationalIon channels.

GRIK1 GRIK2 GRIK3 RYR2

1.03e-0470384MODULE_316
DrugT0702

XIAP RYR2 RYR3 ITPR3

6.44e-0725634CID000005908
DrugBr2BAPTA

RYR2 RYR3 ITPR3

7.01e-077633CID003081001
Drug[[(2R,3S,4R)-5-(2-amino-6-oxo-3H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [(2R,3S,4R,5R)-3,4,5-trihydroxyoxolan-2-yl]methyl hydrogen phosphate

RYR2 RYR3 ITPR3

7.01e-077633CID009547999
DrugLY339434

GRIK1 GRIK2 GRIK3

1.68e-069633CID006324635
DrugR 478

RYR2 RYR3 ITPR3

3.28e-0611633CID000084223
Drug8-amino-cADPR

RYR2 RYR3 ITPR3

3.28e-0611633CID003081323
Drugmag-fura-2

MGAM RYR2 RYR3 ITPR3

3.28e-0637634CID000123839
DrugXeC compound

PIK3CG GRIK1 RYR2 RYR3 ITPR3

3.60e-0684635CID000005701
Drughexachlorophene

UGGT1 CLTC GRIK1 GRIK2 GRIK3

5.06e-0690635CID000003598
Druggamma-aminobutyric acid

CUL4B ABAT IL36B GRIK1 GRIK2 GRIK3 RYR2 RYR3 ITPR3

5.95e-06474639CID000000119
Drug5-nitro-6,7,8,9-tetrahydrobenzo(G)indole-2,3-dione-3-oxime

GRIK1 GRIK2

7.54e-062632ctd:C084273
Drugindo-1

PIK3CG GRIK1 RYR2 RYR3 ITPR3

8.08e-0699635CID000105060
Drugriluzole

GRIK1 GRIK2 GRIK3 RYR2 RYR3 ITPR3

8.66e-06174636CID000005070
DrugGvapspat amide

RYR2 RYR3 ITPR3

8.97e-0615633CID000125015
Drugdecahydroisoquinoline

GRIK1 GRIK2 GRIK3

1.10e-0516633CID000097812
DrugAC1L1FA8

LIG4 GRIK1 GRIK2 GRIK3

1.11e-0550634CID000003150
DrugNSC7524

MGAM GRIK1 GRIK3 RYR2 RYR3 ITPR3

1.12e-05182636CID000005657
Druglamotrigine

ABAT GRIK1 RYR2 RYR3 ITPR3

1.75e-05116635CID000003878
DrugAC1NBU2S

MGAM XIAP RYR2 RYR3 ITPR3

1.82e-05117635CID004473765
DrugAC1L380G

MGAM RYR2 RYR3

1.90e-0519633CID000084698
DrugLY382884

GRIK1 GRIK2 GRIK3

1.90e-0519633CID000656723
Drugkynurenic acid

MGAM ABAT GRIK1 GRIK2 GRIK3

2.23e-05122635CID000003845
Drugfluo-3

GRIK1 GRIK3 RYR2 RYR3 ITPR3

2.23e-05122635CID000104978
DrugValproic Acid

ABAT ACADSB

2.26e-053632DB00313
Drug2-hydroxycarbazole

RYR2 RYR3

2.26e-053632CID000093551
Drugcis-diammineplatinum(II

RYR2 RYR3

2.26e-053632CID000159790
Drug2-hydroxyheptanoic acid

RYR2 RYR3

2.26e-053632CID002750949
DrugRyanodyl 3-(pyridine-3-carboxylate

RYR2 RYR3

2.26e-053632CID005748312
Drug8N3-cADPR

RYR2 RYR3

2.26e-053632CID000127713
Drugaminodantrolene

RYR2 RYR3

2.26e-053632CID009570289
Drugcaffeine

MGAM CCNB3 SYNE1 GRIK1 GRIK2 GRIK3 RYR2 RYR3 ITPR3

2.31e-05562639CID000002519
Druglactobionic acid

MGAM SYNE1 HADHA

2.59e-0521633CID000007314
DrugNS 102

GRIK1 GRIK2 GRIK3

2.99e-0522633CID005282252
Drugpioglitazone

MGAM ABAT LIPC PIK3CG RYR2 RYR3 ITPR3

3.22e-05326637CID000004829
Druggallopamil

MGAM RYR2 RYR3 ITPR3

3.58e-0567634CID000001234
DrugL-Glutamic Acid

ABAT GRIK1 GRIK2 GRIK3

3.80e-0568634DB00142
DrugAC1L2AC7

LRP2 RYR2 RYR3 ITPR3

4.02e-0569634CID000068733
Drugfelbamate

ABAT GRIK1 GRIK2 GRIK3

4.26e-0570634CID000003331
Drugaminothiazole 6

GRIK1 GRIK3

4.51e-054632CID005329388
DrugPCB74

RYR2 RYR3

4.51e-054632CID000036218
Drug148504-47-6

RYR2 RYR3

4.51e-054632CID006444275
Drugacromelic acid B

GRIK1 GRIK3

4.51e-054632CID000158974
DrugSC 38249

RYR2 RYR3

4.51e-054632CID000134834
DrugBrn 1074551

GRIK1 GRIK3

4.51e-054632CID000120220
DrugAC1L1U7A

RYR2 RYR3

4.51e-054632CID000035682
DrugdiCl-HQC

GRIK1 GRIK3

4.51e-054632CID003018579
Drugethosuximide

ABAT RYR2 RYR3 ITPR3

5.30e-0574634CID000003291
Drugbromowillardiine

GRIK1 GRIK3

7.50e-055632CID000167842
Drugipenoxazone

GRIK1 GRIK3

7.50e-055632CID000065882
DrugpBB-PzDA

GRIK1 GRIK3

7.50e-055632CID000124528
Drug3-hydroxy-2-quinoxalinecarboxylic acid

GRIK1 GRIK3

7.50e-055632CID000071001
Drugferrocenium hexafluorophosphate

MGAM SYNE1

7.50e-055632CID011727263
Drugpyrimidine-2,4-dione

MGAM GRIK1

7.50e-055632CID000150747
Drugcis-2,3-piperidine dicarboxylic acid

MGAM GRIK1 GRIK3

7.77e-0530633CID000001226
DrugLY293558

GRIK1 GRIK2 GRIK3

7.77e-0530633CID000127894
Drug4-methylglutamic acid

GRIK1 GRIK2 GRIK3

8.59e-0531633CID000005365
Drugwillardine

GRIK1 GRIK2 GRIK3

9.46e-0532633CID000005123
Drugcobalt-60

MGAM CLTC GRIK1 GRIK3 RYR2 RYR3 ITPR3

9.94e-05390637CID000061492
DrugCNS 1145

RYR2 RYR3 ITPR3

1.04e-0433633CID000190902
DrugIHC-64

RYR2 RYR3 ITPR3

1.04e-0433633CID000162753
Druggabapentin

ABAT GRIK1 RYR2 RYR3 ITPR3

1.05e-04169635CID000003446
Drug3-acetylisoquinoline

GRIK1 GRIK3

1.12e-046632CID000124656
DrugMBED

RYR2 RYR3

1.12e-046632CID000129958
Drugchloro-m-cresol

RYR2 RYR3

1.12e-046632CID000012008
DrugAC1O528X

RYR2 RYR3

1.12e-046632CID006475857
DrugNSC114784

RYR2 RYR3

1.12e-046632CID000419425
DrugR,S)-AMPA

CCNB3 GRIK1 GRIK3

1.35e-0436633CID000001221
Drug5-iodouracil

MGAM ABAT SYNE1

1.35e-0436633CID000069672
Drug1,2-dichlorohexafluorocyclobutane

GRIK2 RYR2 RYR3

1.47e-0437633CID000009643
Druggamma-Glu-Gly

MGAM GRIK1 GRIK3

1.47e-0437633CID000100099
Drugacrylyl-coenzyme A

MGAM ACADSB HADHA

1.47e-0437633CID000439340
Drug4-chloro-m-cresol

RYR2 RYR3 ITPR3

1.47e-0437633CID000001732
DrugAzumoleno

RYR2 RYR3

1.57e-047632CID000056259
Drugdec-5-ene

ACADSB SYNE1

1.57e-047632CID000023916
Drugmag-indo-1

MGAM RYR3

1.57e-047632CID000131881
Drugfluorocyclobutane

GRIK1 GRIK3

1.57e-047632CID011051569
Drugnitroxide

SYNE1 CLTC

1.57e-047632CID005460582
Drugnitrendipine

GRIK1 RYR2 RYR3 ITPR3

1.58e-0498634CID000004507
DrugGAMs

MGAM GRIK1 GRIK3

1.59e-0438633CID000002935
DrugL-BMAA

GRIK1 GRIK2 GRIK3

1.59e-0438633CID000028558
DrugAC1L98DX

RYR2 RYR3 ITPR3

1.59e-0438633CID000439957
DrugDETC-MeSO

GRIK1 GRIK2 GRIK3

1.72e-0439633CID003035711
DrugNAADP

RYR2 RYR3 ITPR3

1.72e-0439633CID000123952
DrugAC1L1DXE

PIK3CG GRIK1 GRIK3 RYR2 RYR3 ITPR3

1.77e-04299636CID000002548
Drugbaclofen

ABAT GRIK1 RYR2 RYR3 ITPR3

1.87e-04191635CID000002284
DrugAC1L96VB

LIG4 SPTAN1 XIAP RYR2 RYR3

1.87e-04191635CID000439200
DrugKainic Acid

SPTAN1 XIAP GRIK1 GRIK2 GRIK3

2.01e-04194635ctd:D007608
DrugEtofenamate [30544-47-9]; Down 200; 10.8uM; MCF7; HT_HG-U133A

LIG4 STRN3 HSDL2 TRAPPC10 CENPQ

2.06e-041956357327_DN
Drug8-bromoguanosine 3',5'-cyclic monophosphate

IL36B PIK3CG GRIK1 RYR2 RYR3 ITPR3

2.08e-04308636CID000001915
Drug9 mM of H

MGAM ITPR3

2.09e-048632CID000130464
DrugAC1L1B65

GRIK1 GRIK3

2.09e-048632CID000001300
Drugperzinfotel

GRIK1 GRIK3

2.09e-048632CID006918236
DrugProtriptyline hydrochloride [1225-55-4]; Up 200; 13.4uM; PC3; HT_HG-U133A

LIG4 STRN3 LRP2 DZIP1 RYR2

2.11e-041966356338_UP
DrugProcyclidine hydrochloride [1508-76-5]; Up 200; 12.4uM; HL60; HT_HG-U133A

KLHL3 LIG4 ABAT RRP12 EPAS1

2.16e-041976352991_UP
DrugBicuculline (+) [485-49-4]; Up 200; 10.8uM; MCF7; HT_HG-U133A

STRN3 PPP2R5B GRIK1 SLC35G2 ZNF471

2.16e-041976354397_UP
DrugChlorpheniramine maleate [113-92-8]; Down 200; 10.2uM; MCF7; HT_HG-U133A

PPP2R5B NEUROD4 LRP2 AKAP10 RYR2

2.21e-041986352217_DN
DrugPyrilamine maleate [59-33-6]; Down 200; 10uM; PC3; HT_HG-U133A

KLHL3 PPP2R5B ACADSB AKAP10 SLC35G2

2.21e-041986355869_DN
DrugIsoniazid [54-85-3]; Down 200; 29.2uM; PC3; HT_HG-U133A

CUL4B LIG4 SYNE1 TRAPPC10 ITPR3

2.26e-041996352083_DN
DrugJoro spider toxin

GRIK1 GRIK2 GRIK3

2.30e-0443633CID000119582
Drugescina

RYR2 RYR3 ITPR3

2.47e-0444633CID006433489
Diseasecongenital myopathy 1A (implicated_via_orthology)

RYR2 RYR3

1.18e-053592DOID:3529 (implicated_via_orthology)
Diseasemalignant hyperthermia (implicated_via_orthology)

RYR2 RYR3

1.18e-053592DOID:8545 (implicated_via_orthology)
Diseaseamino acid measurement

ABAT GLB1L3 SYNE1 LRP2 GRIK2 EPAS1 RYR2 RYR3

5.88e-05678598EFO_0005134
Diseaseoral microbiome measurement

APPL2 KIAA1217 GRIK2

8.25e-0542593EFO_0801229
DiseaseDrug habituation

APPL2 SYNE1 GRIK2 CSMD3

8.45e-05115594C0013170
DiseaseSubstance-Related Disorders

APPL2 SYNE1 GRIK2 CSMD3

8.45e-05115594C0236969
DiseaseDrug abuse

APPL2 SYNE1 GRIK2 CSMD3

8.45e-05115594C0013146
DiseaseDrug Use Disorders

APPL2 SYNE1 GRIK2 CSMD3

8.45e-05115594C0013222
DiseaseDrug Dependence

APPL2 SYNE1 GRIK2 CSMD3

8.45e-05115594C1510472
DiseaseSubstance Dependence

APPL2 SYNE1 GRIK2 CSMD3

8.45e-05115594C0038580
DiseaseSubstance Use Disorders

APPL2 SYNE1 GRIK2 CSMD3

8.45e-05115594C0038586
DiseaseOrganic Mental Disorders, Substance-Induced

APPL2 SYNE1 GRIK2 CSMD3

8.45e-05115594C0029231
DiseasePrescription Drug Abuse

APPL2 SYNE1 GRIK2 CSMD3

8.45e-05115594C4316881
DiseaseSubstance abuse problem

APPL2 SYNE1 GRIK2 CSMD3

8.73e-05116594C0740858
DiseaseAutistic Disorder

ABAT ACADSB PIK3CG GRIK2 CSMD3

1.77e-04261595C0004352
Diseasesmoking cessation

KIAA1217 TTC12 CSMD3 ARAP2 ITPR3

4.84e-04325595EFO_0004319
Diseasepulmonary hypertension (biomarker_via_orthology)

EPAS1 RYR2 RYR3

5.59e-0480593DOID:6432 (biomarker_via_orthology)
Diseaseserum IgG glycosylation measurement

CWF19L2 TXLNB TOPAZ1 NEUROD4 EPAS1 RYR2

6.13e-04523596EFO_0005193
Diseasecolorectal health

LIG4 GRIK2 TEX9 RYR2

7.10e-04201594EFO_0008460
Diseasestatus epilepticus (implicated_via_orthology)

ABAT GRIK1

8.05e-0421592DOID:1824 (implicated_via_orthology)
Diseasephosphatidylserines measurement

LIPC GRIK2

9.68e-0423592EFO_0020049
DiseaseHuntington's disease (is_implicated_in)

ABAT GRIK2

9.68e-0423592DOID:12858 (is_implicated_in)
DiseaseSensorineural Hearing Loss (disorder)

LRP2 YME1L1

9.68e-0423592C0018784
Diseaseattention deficit hyperactivity disorder, unipolar depression, bipolar disorder, autism spectrum disorder, schizophrenia

LIG4 SYNE1 GRIK1

1.10e-03101593EFO_0003756, EFO_0003761, EFO_0003888, MONDO_0004985, MONDO_0005090

Protein segments in the cluster

PeptideGeneStartEntry
KTFMEMNGKLFDELT

PPP2R5B

426

Q15173
GKKSKDMSTERDFFM

EPAS1

156

Q99814
MKSMSTFIEEAYKKL

CENPQ

251

Q7L2Z9
DFILMKKMGIKSGFT

CSMD3

31

Q7Z407
KIMPASTFDMDKLKS

CARNMT1

146

Q8N4J0
SSLFMIMLGDKEKTF

TBC1D32

1071

Q96NH3
DVRKSKGSMFSQAMK

AKAP10

606

O43572
MTFFKKSKISTYEKM

GRIK1

706

P39086
SLFKSSKPFKVMMTA

GPR33

236

Q49SQ1
TFTDEEMMIKSSVKK

ACADSB

56

P45954
SSKHDKMFSLSSMKF

ARAP2

1476

Q8WZ64
FGDFLTVMTQKMSEK

CETN2

86

P41208
MEEDSFFMESMSFKK

CCNB3

256

Q8WWL7
MMSDKKSERFFKVLH

ITPR3

1776

Q14573
AFSKMNGSMDKKSST

LRRC8A

186

Q8IWT6
FEKMMSGSDIKSTDK

GLB1L3

636

Q8NCI6
MGSEKVTEMYQFKFK

HORMAD2

111

Q8N7B1
GFHSMKVKVMTEATK

HORMAD2

226

Q8N7B1
KKSIIGMMEFSLFGI

MGAM

2431

O43451
DVMTFSKKMMTGGFF

ABAT

351

P80404
ATNMKMFTSKLKEGS

FSIP2

3161

Q5CZC0
SAVKMKMFGKLTRDT

GPATCH1

596

Q9BRR8
KLFMRMASKFMGKTD

CWF19L2

616

Q2TBE0
TFTMSLLGTKEKMQK

LIPC

371

P11150
MTTDDFVKMFSGKLK

HSDL2

371

Q6YN16
KKFMETTMNKKGDFL

GBP6

381

Q6ZN66
EKMGKKLKCMFSSFF

FMO6P

411

O60774
FFSDMSKHMIFKQKI

LRP2

756

P98164
KKDKDFSSMRTNIGM

IL36B

146

Q9NZH7
TFMQKGTKFDIKRMV

LIG4

341

P49917
AFTSKLEGMFKDMEL

CUL4A

486

Q13619
FKKGAEMFSKRMDSF

APPL2

211

Q8NEU8
MKISSMGELTSKEFE

DNAH14

701

Q0VDD8
KFGELVMTKESKALM

HADHA

326

P40939
CAMFTGDMSESKAKK

KLHL3

76

Q9UH77
MTFFKKSKISTYDKM

GRIK2

691

Q13002
AVKDGATMTFFKKSK

GRIK3

686

Q13003
VKKMTVKDMVTAFFS

RYR2

4271

Q92736
FTSKLEGMFKDMELS

CUL4B

641

Q13620
KSFPFVKMFITKMIS

COL6A6

41

A6NMZ7
KFFDNKTGKMIHSMV

STRN3

706

Q13033
EGKEMFATMSKLKEQ

SYNE1

781

Q8NF91
PDKTMMDGSFSFKLL

LIPI

346

Q6XZB0
KTFTMSVSEMKSSGK

ARHGAP42

296

A6NI28
MKKKGRAFFGTMDTL

SLC35G2

61

Q8TBE7
ITSYSKDASSEKMMK

KIAA1217

586

Q5T5P2
EMFMKEFKELTSKNS

DZIP1

306

Q86YF9
KFSDTSKAFMDIMSA

RRP12

186

Q5JTH9
KSKMKAHTMTDDVTF

CLTC

96

Q00610
QSFFTKMAKKKSLMD

PIK3CG

246

P48736
RMGFSFKDIKKIMEE

XIAP

381

P98170
FLTGDSKSKMSKAMQ

RYR3

3326

Q15413
KEFSMMFKHFDKDKS

SPTAN1

2326

Q13813
MEMASKMKDTGFIVF

NIPAL4

186

Q0D2K0
TMKELEFSKDKILMG

YME1L1

566

Q96TA2
GYESMASKEDFKSMK

TOPAZ1

436

Q8N9V7
ASKEDFKSMKSFIGK

TOPAZ1

441

Q8N9V7
FEKQMGSHEMFSKKE

ZNF471

131

Q9BX82
KMMKFLKTGGETASR

TTC12

566

Q9H892
FATFKQEMDKTTKKM

TXLNB

381

Q8N3L3
LMSFTKNLGKFEDDM

TRAPPC10

191

P48553
AAKMLSFTEEEFMKA

TEX9

371

Q8N6V9
MDFSLFKEVFESSKM

UGGT1

856

Q9NYU2
EVFTTFKQEMEKMTK

TXLNA

406

P40222
MSKTFVKSKEMGELV

NEUROD4

1

Q9HD90