Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	peptide receptor activity	OGFRL1 NPBWR2 LTB4R2 F2RL1 GPR139 SORCS2	7.41e-05	140	100	6	GO:0001653
GeneOntologyMolecularFunction	short-chain fatty acid transmembrane transporter activity	SLC22A9 SLC22A10	2.46e-04	5	100	2	GO:0015636
GeneOntologyCellularComponent	IRE1-TRAF2-ASK1 complex	ERN1 ERN2	1.43e-04	4	103	2	GO:1990604
Domain	Clathrin_H-chain_propeller_rpt	CLTCL1 CLTC	2.73e-05	2	98	2	IPR022365
Domain	Clathrin-link	CLTCL1 CLTC	2.73e-05	2	98	2	PF09268
Domain	-	CLTCL1 CLTC	2.73e-05	2	98	2	2.130.10.110
Domain	Clathrin_H-chain_link/propller	CLTCL1 CLTC	2.73e-05	2	98	2	IPR016025
Domain	Clathrin_propel	CLTCL1 CLTC	2.73e-05	2	98	2	PF01394
Domain	Clathrin_heavy_chain	CLTCL1 CLTC	2.73e-05	2	98	2	IPR016341
Domain	Clathrin_H-chain_linker_core	CLTCL1 CLTC	2.73e-05	2	98	2	IPR015348
Domain	Clathrin_H-chain_propeller_N	CLTCL1 CLTC	2.73e-05	2	98	2	IPR001473
Domain	Clathrin_H-chain_linker	CLTCL1 CLTC	8.15e-05	3	98	2	IPR012331
Domain	Ribonuc_2-5A	ERN1 ERN2	8.15e-05	3	98	2	PF06479
Domain	KEN	ERN1 ERN2	8.15e-05	3	98	2	PS51392
Domain	KEN_dom	ERN1 ERN2	8.15e-05	3	98	2	IPR010513
Domain	PQQ	ERN1 ERN2	8.15e-05	3	98	2	PF01011
Domain	CLH	CLTCL1 CLTC	8.15e-05	3	98	2	SM00299
Domain	NKAIN	NKAIN2 NKAIN4	1.62e-04	4	98	2	PF05640
Domain	Na/K-Atpase_Interacting	NKAIN2 NKAIN4	1.62e-04	4	98	2	IPR008516
Domain	PUG	ERN1 ERN2	2.70e-04	5	98	2	SM00580
Domain	PQQ	ERN1 ERN2	4.03e-04	6	98	2	SM00564
Domain	PQQ_beta_propeller_repeat	ERN1 ERN2	4.03e-04	6	98	2	IPR018391
Domain	-	ERN1 ERN2	4.03e-04	6	98	2	2.140.10.10
Domain	Quinoprotein_ADH-like_fam	ERN1 ERN2	4.03e-04	6	98	2	IPR027295
Domain	PUB_domain	ERN1 ERN2	4.03e-04	6	98	2	IPR018997
Domain	PQQ_repeat	ERN1 ERN2	4.03e-04	6	98	2	IPR002372
Domain	Clathrin	CLTCL1 CLTC	5.63e-04	7	98	2	PF00637
Domain	CHCR	CLTCL1 CLTC	5.63e-04	7	98	2	PS50236
Domain	Calx_beta	FRAS1 ADGRV1	7.48e-04	8	98	2	SM00237
Domain	Clathrin_H-chain/VPS_repeat	CLTCL1 CLTC	7.48e-04	8	98	2	IPR000547
Domain	HP	AVIL SVIL	7.48e-04	8	98	2	PS51089
Domain	-	AVIL SVIL	7.48e-04	8	98	2	1.10.950.10
Domain	Villin/Gelsolin	AVIL SVIL	7.48e-04	8	98	2	IPR007122
Domain	VHP	AVIL SVIL	7.48e-04	8	98	2	PF02209
Domain	Villin_headpiece	AVIL SVIL	7.48e-04	8	98	2	IPR003128
Domain	GEL	AVIL SVIL	7.48e-04	8	98	2	SM00262
Domain	VHP	AVIL SVIL	7.48e-04	8	98	2	SM00153
Domain	-	CLTCL1 WFS1 TMTC2 MAU2 CLTC CSTF3	7.78e-04	207	98	6	1.25.40.10
Domain	Calx_beta	FRAS1 ADGRV1	9.58e-04	9	98	2	IPR003644
Domain	SAP_B	CNPY4 AOAH	9.58e-04	9	98	2	PS50015
Domain	Calx-beta	FRAS1 ADGRV1	9.58e-04	9	98	2	PF03160
Domain	TPR-like_helical_dom	CLTCL1 WFS1 TMTC2 MAU2 CLTC CSTF3	1.43e-03	233	98	6	IPR011990
Domain	ARM-type_fold	RELCH CLTCL1 RANBP17 SF3B1 PIK3CB CLTC XPO7	2.06e-03	339	98	7	IPR016024
Domain	Gelsolin	AVIL SVIL	2.38e-03	14	98	2	PF00626
Domain	Gelsolin-like_dom	AVIL SVIL	2.38e-03	14	98	2	IPR007123
Domain	Quinoprotein_ADH-like_supfam	ERN1 AHCTF1 ERN2	2.71e-03	53	98	3	IPR011047
Domain	IBN_N	RANBP17 XPO7	2.74e-03	15	98	2	PF03810
Domain	IBN_N	RANBP17 XPO7	3.12e-03	16	98	2	SM00913
Domain	Importin-beta_N	RANBP17 XPO7	3.52e-03	17	98	2	IPR001494
Pubmed	IRE1 prevents endoplasmic reticulum membrane permeabilization and cell death under pathological conditions.	ERN1 WFS1 ERN2	5.01e-07	6	103	3	26106220
Pubmed	The molecular basis for selective inhibition of unconventional mRNA splicing by an IRE1-binding small molecule.	ERN1 ERN2	8.69e-06	2	103	2	22315414
Pubmed	Role of proteinase-activated receptor-2 on cyclooxygenase-2 expression in H. pylori-infected gastric epithelial cells.	F2RL1 PTGS2	8.69e-06	2	103	2	17405913
Pubmed	Translational control by the ER transmembrane kinase/ribonuclease IRE1 under ER stress.	ERN1 ERN2	8.69e-06	2	103	2	11175748
Pubmed	Endoplasmic reticulum stress in the regulation of liver diseases: Involvement of Regulated IRE1α and β-dependent decay and miRNA.	ERN1 ERN2	8.69e-06	2	103	2	27774654
Pubmed	Characterization of two homologs of Ire1p, a kinase/endoribonuclease in yeast, in Arabidopsis thaliana.	ERN1 ERN2	8.69e-06	2	103	2	12020828
Pubmed	Characterization of a second human clathrin heavy chain polypeptide gene (CLH-22) from chromosome 22q11.	CLTCL1 CLTC	8.69e-06	2	103	2	8733129
Pubmed	Role of mast cells and protease-activated receptor-2 in cyclooxygenase-2 expression in urothelial cells.	F2RL1 PTGS2	8.69e-06	2	103	2	19675284
Pubmed	PAR-2 activation, PGE2, and COX-2 in human asthmatic and nonasthmatic airway smooth muscle cells.	F2RL1 PTGS2	8.69e-06	2	103	2	12754192
Pubmed	Identification of a novel putative Ran-binding protein and its close homologue.	RANBP17 XPO7	8.69e-06	2	103	2	11071879
Pubmed	CHC22 and CHC17 clathrins have distinct biochemical properties and display differential regulation and function.	CLTCL1 CLTC	8.69e-06	2	103	2	29097553
Pubmed	The clathrin heavy chain isoform CHC22 functions in a novel endosomal sorting step.	CLTCL1 CLTC	8.69e-06	2	103	2	20065094
Pubmed	Autocrine tumor necrosis factor alpha links endoplasmic reticulum stress to the membrane death receptor pathway through IRE1alpha-mediated NF-kappaB activation and down-regulation of TRAF2 expression.	ERN1 ERN2	8.69e-06	2	103	2	16581782
Pubmed	RNase domains determine the functional difference between IRE1alpha and IRE1beta.	ERN1 ERN2	8.69e-06	2	103	2	18242182
Pubmed	Regulation of insulin biosynthesis in pancreatic beta cells by an endoplasmic reticulum-resident protein kinase IRE1.	ERN1 ERN2	8.69e-06	2	103	2	16950141
Pubmed	The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery.	WFS1 AHCTF1 SMPD4 YIF1A IGF2BP2 SF3B1 FDFT1 ALG9 CLTC TMX4 CNOT1 TOP2A ADPGK XPO7	1.27e-05	1203	103	14	29180619
Pubmed	PDCD4 interacting with PIK3CB and CTSZ promotes the apoptosis of multiple myeloma cells.	PIK3CB CTSZ	2.60e-05	3	103	2	39190024
Pubmed	IRE1-mediated unconventional mRNA splicing and S2P-mediated ATF6 cleavage merge to regulate XBP1 in signaling the unfolded protein response.	ERN1 ERN2	2.60e-05	3	103	2	11850408
Pubmed	Identification of a novel murine organic anion transporter like protein 1 (OATLP1) expressed in the kidney.	SLC22A9 SLC22A10	2.60e-05	3	103	2	17079864
Pubmed	Functional equivalence of the clathrin heavy chains CHC17 and CHC22 in endocytosis and mitosis.	CLTCL1 CLTC	2.60e-05	3	103	2	19509056
Pubmed	[Relationship of cyclooxygenase-2 and multidrug resistance associated factors to chemosensitivities in gastrointestinal carcinomas].	PTGS2 TOP2A	2.60e-05	3	103	2	20369487
Pubmed	Phosphorylation of IRE1 at S729 regulates RIDD in B cells and antibody production after immunization.	ERN1 ERN2	2.60e-05	3	103	2	29511123
Pubmed	Renal expression of organic anion transporter Oat5 in rats and mice exhibits the female-dominant sex differences.	SLC22A9 SLC22A10	2.60e-05	3	103	2	20865662
Pubmed	The crystal structure of human IRE1 luminal domain reveals a conserved dimerization interface required for activation of the unfolded protein response.	ERN1 ERN2	2.60e-05	3	103	2	16973740
Pubmed	Identification of RANBP16 and RANBP17 as novel interaction partners for the bHLH transcription factor E12.	RANBP17 XPO7	2.60e-05	3	103	2	20503194
Pubmed	Synoviolin promotes IRE1 ubiquitination and degradation in synovial fibroblasts from mice with collagen-induced arthritis.	ERN1 ERN2	2.60e-05	3	103	2	18369366
Pubmed	Characterization of mouse organic anion transporter 5 as a renal steroid sulfate transporter.	SLC22A9 SLC22A10	2.60e-05	3	103	2	16150593
Pubmed	Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1.	ERN1 ERN2	2.60e-05	3	103	2	10650002
Pubmed	Clathrin promotes centrosome integrity in early mitosis through stabilization of centrosomal ch-TOG.	CLTCL1 CLTC	2.60e-05	3	103	2	22891263
Pubmed	Mechanically Activated Piezo Channels Mediate Touch and Suppress Acute Mechanical Pain Response in Mice.	PIEZO2 AVIL	2.60e-05	3	103	2	30726728
Pubmed	Identification of a novel organic anion transporter mediating carnitine transport in mouse liver and kidney.	SLC22A9 SLC22A10	2.60e-05	3	103	2	20332632
Pubmed	Protease-activated receptors upregulate cyclooxygenase-2 expression in human endothelial cells.	F2RL1 PTGS2	2.60e-05	3	103	2	12195707
Pubmed	Cloning of mammalian Ire1 reveals diversity in the ER stress responses.	ERN1 ERN2	2.60e-05	3	103	2	9755171
Pubmed	Clathrin isoform CHC22, a component of neuromuscular and myotendinous junctions, binds sorting nexin 5 and has increased expression during myogenesis and muscle regeneration.	CLTCL1 CLTC	2.60e-05	3	103	2	15133132
Pubmed	ASK1 is essential for endoplasmic reticulum stress-induced neuronal cell death triggered by expanded polyglutamine repeats.	ERN1 ERN2	5.19e-05	4	103	2	12050113
Pubmed	Analysis of a large cluster of SLC22 transporter genes, including novel USTs, reveals species-specific amplification of subsets of family members.	SLC22A9 SLC22A10	5.19e-05	4	103	2	19417012
Pubmed	Evaluation of genome-wide association study-identified type 2 diabetes loci in African Americans.	WFS1 IGF2BP2	5.19e-05	4	103	2	23144361
Pubmed	Regulated IRE1-dependent decay participates in curtailing immunoglobulin secretion from plasma cells.	ERN1 ERN2	5.19e-05	4	103	2	24242955
Pubmed	Identification and functional assessment of the novel murine organic anion transporter Oat5 (Slc22a19) expressed in kidney.	SLC22A9 SLC22A10	5.19e-05	4	103	2	15068970
Pubmed	The search for putative unifying genetic factors for components of the metabolic syndrome.	WFS1 IGF2BP2	5.19e-05	4	103	2	18853134
Pubmed	Neutrophils control the magnitude and spread of the immune response in a thromboxane A2-mediated process.	PTGS2 IFNAR1	5.19e-05	4	103	2	23337807
Pubmed	Aberrant methylation of ATG2B, ATG4D, ATG9A and ATG9B CpG island promoter is associated with decreased mRNA expression in sporadic breast carcinoma.	ATG9B ATG2B	5.19e-05	4	103	2	27265029
Pubmed	Regulated IRE1-dependent mRNA decay sets the threshold for dendritic cell survival.	ERN1 ERN2	5.19e-05	4	103	2	28459443
Pubmed	Defective ATG16L1-mediated removal of IRE1α drives Crohn's disease-like ileitis.	ERN1 ERN2	5.19e-05	4	103	2	28082357
Pubmed	NR2F1 and IRE1beta suppress microsomal triglyceride transfer protein expression and lipoprotein assembly in undifferentiated intestinal epithelial cells.	ERN1 ERN2	5.19e-05	4	103	2	20007910
Pubmed	Endoplasmic reticulum stress increases the expression of methylenetetrahydrofolate reductase through the IRE1 transducer.	ERN1 ERN2	5.19e-05	4	103	2	18065414
Pubmed	AIP1 is critical in transducing IRE1-mediated endoplasmic reticulum stress response.	ERN1 ERN2	5.19e-05	4	103	2	18281285
Pubmed	Isolation of a family of organic anion transporters from human liver and kidney.	SLC22A9 SLC22A10	5.19e-05	4	103	2	11327718
Pubmed	HIP1 functions in clathrin-mediated endocytosis through binding to clathrin and adaptor protein 2.	CLTCL1 CLTC	5.19e-05	4	103	2	11517213
Pubmed	Frameshift mutations of autophagy-related genes ATG2B, ATG5, ATG9B and ATG12 in gastric and colorectal cancers with microsatellite instability.	ATG9B ATG2B	5.19e-05	4	103	2	19197948
Pubmed	ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.	TOR1AIP2 FRAS1 WFS1 CNPY4 TMTC2 LMBRD2 CELSR1 FDFT1 ALG9 SVIL TMX4 ADPGK CTSZ	5.60e-05	1201	103	13	35696571
Pubmed	Toll-like receptor-mediated IRE1α activation as a therapeutic target for inflammatory arthritis.	ERN1 ERN2	8.64e-05	5	103	2	23942232
Pubmed	Clathrin assembly lymphoid myeloid leukemia (CALM) protein: localization in endocytic-coated pits, interactions with clathrin, and the impact of overexpression on clathrin-mediated traffic.	CLTCL1 CLTC	8.64e-05	5	103	2	10436022
Pubmed	UPR-induced resistance to etoposide is downstream of PERK and independent of changes in topoisomerase IIα levels.	ERN1 TOP2A	8.64e-05	5	103	2	23144714
Pubmed	Macrophage autophagy in immunity to Cryptococcus neoformans and Candida albicans.	ATG9B ATG2B	8.64e-05	5	103	2	22710871
Pubmed	Proliferative action of mast-cell tryptase is mediated by PAR2, COX2, prostaglandins, and PPARgamma : Possible relevance to human fibrotic disorders.	F2RL1 PTGS2	8.64e-05	5	103	2	12397176
Pubmed	Large-scale mapping of human protein-protein interactions by mass spectrometry.	SMPD4 OGG1 STRN EIF2D IGF2BP2 SF3B1 FDFT1 ASB3 CLTC FES CSTF3 CNOT1 XPO7	1.09e-04	1284	103	13	17353931
Pubmed	Identification of new transmembrane proteins concentrated at the nuclear envelope using organellar proteomics of mesenchymal cells.	SMPD4 TMX4	1.29e-04	6	103	2	31142202
Pubmed	Three-dimensional reconstructions of mechanosensory end organs suggest a unifying mechanism underlying dynamic, light touch.	PIEZO2 AVIL	1.29e-04	6	103	2	37725982
Pubmed	Phosphoinositide 3-kinase regulates beta2-adrenergic receptor endocytosis by AP-2 recruitment to the receptor/beta-arrestin complex.	PIK3CB CLTC	1.29e-04	6	103	2	12163475
Pubmed	Stage-specific expression patterns of ER stress-related molecules in mice molars: Implications for tooth development.	ERN1 ERN2	1.29e-04	6	103	2	32758541
Pubmed	Quantitative Proteomics Links the LRRC59 Interactome to mRNA Translation on the ER Membrane.	FRAS1 WFS1 SMPD4 SF3B1 FDFT1 TMX4 CNOT1	1.31e-04	375	103	7	32788342
Pubmed	Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism.	SPG11 MAU2 SLC66A1 TAF6L SLC22A9 EIF2D PIK3CB FDFT1 CLVS2 ALG9 CLTC DEPDC5 CNOT1	1.52e-04	1327	103	13	32694731
Pubmed	AATF mediates an antiapoptotic effect of the unfolded protein response through transcriptional regulation of AKT1.	ERN1 WFS1	1.81e-04	7	103	2	19911006
Pubmed	A role for the CHC22 clathrin heavy-chain isoform in human glucose metabolism.	CLTCL1 CLTC	1.81e-04	7	103	2	19478182
Pubmed	Negative feedback control of osteoclast formation through ubiquitin-mediated down-regulation of NFATc1.	CBLB IFNAR1	1.81e-04	7	103	2	20037154
Pubmed	A novel family of transmembrane proteins interacting with beta subunits of the Na,K-ATPase.	NKAIN2 NKAIN4	1.81e-04	7	103	2	17606467
Pubmed	A role for Piezo2 in EPAC1-dependent mechanical allodynia.	PIEZO2 AVIL	1.81e-04	7	103	2	23575686
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	RELCH SMPD4 SPG11 ADGRV1 STAB1 TMX4 DEPDC5 CNOT1	1.83e-04	529	103	8	14621295
Pubmed	Dengue virus modulates the unfolded protein response in a time-dependent manner.	ERN1 ERN2	2.40e-04	8	103	2	21385877
Pubmed	Diversity and rearrangement of the human T cell rearranging gamma genes: nine germ-line variable genes belonging to two subgroups.	TRGV1 TRGV8	2.40e-04	8	103	2	2938743
Pubmed	γ-Protocadherins control synapse formation and peripheral branching of touch sensory neurons.	PIEZO2 AVIL	2.40e-04	8	103	2	37028432
Pubmed	Identification of six putative human transporters with structural similarity to the drug transporter SLC22 family.	SLC22A24 SLC22A9	2.40e-04	8	103	2	17714910
Pubmed	Shotgun sequencing of the human transcriptome with ORF expressed sequence tags.	EFCAB5 ZSWIM8 CLTCL1 ERN1 STAB1 SF3B1 TENM1 UNC80	2.43e-04	552	103	8	10737800
Pubmed	The inhibitory effect of recent type 2 diabetes risk loci on insulin secretion is modulated by insulin sensitivity.	WFS1 IGF2BP2	3.08e-04	9	103	2	19258404
Pubmed	Activated Cdc42-associated kinase 1 is a component of EGF receptor signaling complex and regulates EGF receptor degradation.	CBLB CLTC	3.08e-04	9	103	2	17182860
Pubmed	Association between polymorphisms in SLC30A8, HHEX, CDKN2A/B, IGF2BP2, FTO, WFS1, CDKAL1, KCNQ1 and type 2 diabetes in the Korean population.	WFS1 IGF2BP2	3.08e-04	9	103	2	18991055
Pubmed	Identification of two novel RanGTP-binding proteins belonging to the importin beta superfamily.	RANBP17 XPO7	3.08e-04	9	103	2	11024021
Pubmed	Predicting type 2 diabetes based on polymorphisms from genome-wide association studies: a population-based study.	WFS1 IGF2BP2	3.85e-04	10	103	2	18694974
Pubmed	Evidence of interaction between type 2 diabetes susceptibility genes and dietary fat intake for adiposity and glucose homeostasis-related phenotypes.	WFS1 IGF2BP2	3.85e-04	10	103	2	20215779
Pubmed	Association between insulin secretion, insulin sensitivity and type 2 diabetes susceptibility variants identified in genome-wide association studies.	WFS1 IGF2BP2	3.85e-04	10	103	2	19082521
Pubmed	CALM regulates clathrin-coated vesicle size and maturation by directly sensing and driving membrane curvature.	CLTCL1 CLTC	3.85e-04	10	103	2	25898166
Pubmed	Implication of genetic variants near SLC30A8, HHEX, CDKAL1, CDKN2A/B, IGF2BP2, FTO, TCF2, KCNQ1, and WFS1 in type 2 diabetes in a Chinese population.	WFS1 IGF2BP2	3.85e-04	10	103	2	20509872
Pubmed	Genetic predisposition, Western dietary pattern, and the risk of type 2 diabetes in men.	WFS1 IGF2BP2	3.85e-04	10	103	2	19279076
Pubmed	Glycemia determines the effect of type 2 diabetes risk genes on insulin secretion.	WFS1 IGF2BP2	4.69e-04	11	103	2	20802253
Pubmed	Variants of the PPARG, IGF2BP2, CDKAL1, HHEX, and TCF7L2 genes confer risk of type 2 diabetes independently of BMI in the German KORA studies.	WFS1 IGF2BP2	4.69e-04	11	103	2	18597214
Pubmed	Ubiquitin-specific protease 8 deubiquitinates Sec31A and decreases large COPII carriers and collagen IV secretion.	CLTCL1 CLTC	4.69e-04	11	103	2	29604273
Pubmed	CRL4(WDR23)-Mediated SLBP Ubiquitylation Ensures Histone Supply during DNA Replication.	SF3B1 CSTF3	4.69e-04	11	103	2	27203182
Pubmed	The RNA binding protein MEX3A promotes tumor progression of breast cancer by post-transcriptional regulation of IGFBP4.	AHCTF1 OGG1 SVIL CLTC CNOT1 TOP2A	4.76e-04	332	103	6	37433992
Pubmed	FAM105A/OTULINL Is a Pseudodeubiquitinase of the OTU-Class that Localizes to the ER Membrane.	TOR1AIP2 WFS1 SMPD4 YIF1A FDFT1 ALG9 TMX4	4.99e-04	468	103	7	31056421
Pubmed	Common type 2 diabetes risk gene variants associate with gestational diabetes.	WFS1 IGF2BP2	6.63e-04	13	103	2	18984664
Pubmed	Identification of a novel murine organic anion transporter family member, OAT6, expressed in olfactory mucosa.	SLC22A9 SLC22A10	6.63e-04	13	103	2	15369770
Pubmed	Mast cell-dependent anorexia and hypothermia induced by mucosal activation of Toll-like receptor 7.	PTGS2 IFNAR1	6.63e-04	13	103	2	18480244
Pubmed	Molecular physiology of renal organic anion transporters.	SLC22A9 SLC22A10	6.63e-04	13	103	2	16403838
Pubmed	Replication of recently described type 2 diabetes gene variants in a South Indian population.	WFS1 IGF2BP2	6.63e-04	13	103	2	20580033
Pubmed	Association analysis of type 2 diabetes Loci in type 1 diabetes.	WFS1 IGF2BP2	6.63e-04	13	103	2	18426861
Pubmed	Endofin is required for HD-PTP and ESCRT-0 interdependent endosomal sorting of ubiquitinated transmembrane cargoes.	RELCH CBLB CLTC	7.64e-04	60	103	3	34761192
Pubmed	DRG afferents that mediate physiologic and pathologic mechanosensation from the distal colon.	PIEZO2 AVIL	8.89e-04	15	103	2	37541195
Pubmed	Variable region genes in the human T-cell rearranging gamma (TRG) locus: V-J junction and homology with the mouse genes.	TRGV1 TRGV8	8.89e-04	15	103	2	2969332
Pubmed	Piezo2 senses airway stretch and mediates lung inflation-induced apnoea.	PIEZO2 AVIL	1.01e-03	16	103	2	28002412
Interaction	C2CD4B interactions	ZSWIM8 FRAS1 ADGRV1 CELSR1 SVIL	2.29e-06	44	98	5	int:C2CD4B
Interaction	GPR182 interactions	RELCH WFS1 AHCTF1 SMPD4 SPG11 LMBRD2 F2RL1 FDFT1 PAQR3 ADPGK XPO7	1.32e-05	455	98	11	int:GPR182
Cytoband	11q12.3	SLC22A24 TAF6L SLC22A10	8.74e-05	38	103	3	11q12.3
Cytoband	4q21.21	FRAS1 PAQR3	5.14e-04	15	103	2	4q21.21
Cytoband	12q21.31	TMTC2 OTOGL	7.45e-04	18	103	2	12q21.31
Cytoband	5q13	ADGRV1 F2RL1	1.12e-03	22	103	2	5q13
Cytoband	17q24.2	ERN1 FAM20A	2.08e-03	30	103	2	17q24.2
Cytoband	7p14	TRGV1 TRGV8	2.08e-03	30	103	2	7p14
GeneFamily	Na+/K+ transporting ATPase interacting	NKAIN2 NKAIN4	6.04e-05	4	58	2	659
GeneFamily	Gelsolin/villins	AVIL SVIL	2.80e-04	8	58	2	950
GeneFamily	T cell receptor gamma locus at 7p14	TRGV1 TRGV8	2.24e-03	22	58	2	375
Coexpression	GSE3920_UNTREATED_VS_IFNB_TREATED_ENDOTHELIAL_CELL_UP	AFF3 MAU2 ADGRV1 F2RL1 TXK IFNAR1 SVIL LRATD2	1.28e-06	200	103	8	M6686
Coexpression	GSE9006_HEALTHY_VS_TYPE_1_DIABETES_PBMC_AT_DX_DN	MGAM MAU2 F2RL1 PTGS2 CELSR1 PIK3CB SVIL	1.36e-05	198	103	7	M5776
Coexpression	GSE5589_LPS_VS_LPS_AND_IL10_STIM_IL6_KO_MACROPHAGE_45MIN_UP	SFMBT1 AOAH SPG11 DGUOK TMX4 FUCA1 PAQR3	1.45e-05	200	103	7	M6618
Coexpression	GSE18893_CTRL_VS_TNF_TREATED_TREG_24H_DN	ZSWIM8 ERN1 AFF3 RUSC2 SLC7A4 ASB3 CLTC	1.45e-05	200	103	7	M7296
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MGAM FRAS1 ADGRV1 NKAIN2 PIEZO2 OTOGL TENM1 UNC80	1.15e-08	184	103	8	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MGAM FRAS1 ADGRV1 NKAIN2 PIEZO2 OTOGL TENM1 UNC80	1.15e-08	184	103	8	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MGAM FRAS1 ADGRV1 NKAIN2 PIEZO2 OTOGL TENM1 UNC80	1.15e-08	184	103	8	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	Sigmoid-T_cell-gd_T\|T_cell / Region, Cell class and subclass	AOAH TRGV1 TRGV8 CBLB TXK DZIP3 FES FUCA1	2.20e-08	200	103	8	20844293c155d3f319ceeea9476979bc86515b53
ToppCell	Tracheal-NucSeq-Epithelial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	TMTC2 ADGRV1 ERN2 RANBP17 STRN CELSR1 IGF2BP2 FDFT1	2.20e-08	200	103	8	d3af0a706baf66e3f32e67b17dcfc31e5b32ce0e
ToppCell	5'-Adult-SmallIntestine-Hematopoietic-T_cells-TRGV2_gdT\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ERN1 AOAH TRGV8 CBLB TXK TMX4 DZIP3	3.35e-07	193	103	7	544de0988510cc57744710d7cafe07aa27a0b99d
ToppCell	(1)_T_cell-(17)_gd_T\|(1)_T_cell / shred on Cell_type and subtype	AOAH TRGV8 CBLB TXK DZIP3 FES FUCA1	4.12e-07	199	103	7	4b7d8453d9c6723e51e0c2d6cbca6b7e2d4950dc
ToppCell	Sigmoid-(1)_T_cell-(17)_gd_T\|Sigmoid / shred on region, Cell_type, and subtype	AOAH TRGV1 TRGV8 CBLB TXK DZIP3 FES	4.26e-07	200	103	7	a02e5a69f7101accd8f1394ab1c8007e211187f7
ToppCell	Sigmoid-T_cell-gd_T\|Sigmoid / Region, Cell class and subclass	AOAH TRGV1 TRGV8 CBLB TXK DZIP3 FES	4.26e-07	200	103	7	eef4df008cccdf6297b1c90c986c68793afd8b78
ToppCell	(17)_gd_T\|World / shred on Cell_type and subtype	AOAH TRGV1 TRGV8 CBLB TXK DZIP3 FES	4.41e-07	201	103	7	7fcfe48758acf07cb3dda939ce589ae1518e41c9
ToppCell	droplet-Liver-Npc-18m-Lymphocytic-B_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1E AFF3 FCRLA METTL24 CD37 SORCS2	2.63e-06	168	103	6	ce9fae8b295c668b0959d5007a8bcd401d80e258
ToppCell	10x5'-GI_small-bowel-Lymphocytic_Invariant-Inducer-like\|GI_small-bowel / Manually curated celltypes from each tissue	AFF3 PTGS2 SERPINA11 SVIL FES LRATD2	2.63e-06	168	103	6	d02eba7ece17edcdd47fd6b784c93910ce61090f
ToppCell	10x5'-GI_small-bowel-Lymphocytic_Invariant-Inducer-like-ILC3\|GI_small-bowel / Manually curated celltypes from each tissue	AFF3 PTGS2 SERPINA11 SVIL FES LRATD2	2.81e-06	170	103	6	97df5ffb328196c46568975d2d97722bcc753bf5
ToppCell	droplet-Liver-Npc-18m-Lymphocytic-B_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1E AFF3 FCRLA METTL24 CD37 SORCS2	2.91e-06	171	103	6	584a095ddcbf78aa29527f84b46b5ad3e2edbaa9
ToppCell	5'-Adult-LargeIntestine-Hematopoietic-T_cells-ILC3\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ERN1 AFF3 PTGS2 TXK SERPINA11 FES	2.91e-06	171	103	6	6ab7f103cbdbd49ef687cbb8a42ddc5517af0f7f
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_4-Exc_L4-5_RORB_RPL31P31\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SLC22A24 NKAIN2 SLC22A9 SLC22A10 SORCS2 HS3ST2	3.91e-06	180	103	6	b7513b9816a9cb9f3caaddb2a9fed0be1c7f9805
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_4\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SLC22A24 NKAIN2 SLC22A9 SLC22A10 SORCS2 HS3ST2	3.91e-06	180	103	6	f96c5be4705e3d338c0393d2885ac8d5beccd6fd
ToppCell	ILEUM-non-inflamed-(6)_ILC3\|non-inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	AFF3 PTGS2 TXK SERPINA11 SVIL FES	5.50e-06	191	103	6	6eaf72b41084404bee0db04e4605db745a74995f
ToppCell	PCW_13-14-Mesenchymal-Mesenchymal_fibroblastic-mes_immature1_(0)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	FRAS1 AFF3 TMTC2 CBLB NKAIN2 PIEZO2	6.56e-06	197	103	6	0034bae02ee7fcfea520d453ca3c842ab6963b12
ToppCell	mLN-ILC-ILC\|mLN / Region, Cell class and subclass	ERN1 PTGS2 SERPINA11 IGF2BP2 SVIL FES	6.95e-06	199	103	6	ab09a06cdea2597e9fe4b4b304655e9de4d433f6
ToppCell	mLN-ILC\|mLN / Region, Cell class and subclass	ERN1 PTGS2 SERPINA11 IGF2BP2 SVIL FES	6.95e-06	199	103	6	d6c299312c747fb1b7c53644c53efc03a5fffe85
ToppCell	mLN-(3)_ILC\|mLN / shred on region, Cell_type, and subtype	ERN1 PTGS2 SERPINA11 IGF2BP2 SVIL FES	6.95e-06	199	103	6	00e0e2a766dd9c4d0a65f53d88fa50df4b6a3d60
ToppCell	10x_3'_v2v3-Non-neoplastic-Myeloid-Mono-Mono_anti-infl\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	STAB1 CLTC FUCA1 HS3ST2 FAM20A CTSZ	6.95e-06	199	103	6	f965eb89d6d023c83154276b8fded490fd89c100
ToppCell	mLN-(3)_ILC-(30)_ILC\|mLN / shred on region, Cell_type, and subtype	ERN1 PTGS2 SERPINA11 IGF2BP2 SVIL FES	6.95e-06	199	103	6	33ac6d77099076df01299be429f4ba96f2f34cc1
ToppCell	tumor_Lung-Myeloid_cells-mo-Mac\|Myeloid_cells / Location, Cell class and cell subclass	STAB1 CLTC FUCA1 HS3ST2 FAM20A CTSZ	7.15e-06	200	103	6	58ff8db0ecf71daa86f9a38208e0d9b712cac0b5
ToppCell	Tracheal-NucSeq-Epithelial-Epi_submucosal-gland-SMG_Mucous\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	CACNA1E AFF3 ERN2 STRN CELSR1 FDFT1	7.15e-06	200	103	6	c450a15e21fa72d071ed6e3b9f22de557a0f3cea
ToppCell	Caecum-(1)_T_cell-(17)_gd_T\|Caecum / shred on region, Cell_type, and subtype	AOAH TRGV8 CBLB TXK DZIP3 FES	7.15e-06	200	103	6	2aaa6b37e9f8d95de53f284a42a3ac14e6351b40
ToppCell	(3)_ILC\|World / shred on Cell_type and subtype	AFF3 TXK SERPINA11 IGF2BP2 SVIL FES	7.15e-06	200	103	6	03554b3f323785b1e0b48fa32de0d92065dd798e
ToppCell	Transverse-Dendritic_cell\|Transverse / Region, Cell class and subclass	OGFRL1 PTGS2 STAB1 FES TOP2A CTSZ	7.15e-06	200	103	6	b0e9eaf0e57e53645e272e2cea9f09bfcfe12a9b
ToppCell	Caecum-T_cell-gd_T\|T_cell / Region, Cell class and subclass	AOAH TRGV8 TXK DZIP3 FES FUCA1	7.15e-06	200	103	6	564117144a3059017a07d66f718b9b5a1f18265b
ToppCell	Transverse-(5)_Dendritic_cell\|Transverse / shred on region, Cell_type, and subtype	OGFRL1 PTGS2 STAB1 FES TOP2A CTSZ	7.15e-06	200	103	6	6c32a64f7c38818b93eec1e2d41067e5dbd90541
ToppCell	Tracheal-NucSeq-Epithelial-Epi_submucosal-gland\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	ADGRV1 ERN2 RANBP17 IGF2BP2 FDFT1 SVIL	7.15e-06	200	103	6	0eb9ad8c0373bcc62029ec21c590ed03aaacd039
ToppCell	Caecum-T_cell-gd_T\|Caecum / Region, Cell class and subclass	AOAH TRGV8 CBLB TXK DZIP3 FES	7.15e-06	200	103	6	eaacd14b6d4a1c7d52deab110ed3a6c7d3dc1f8e
ToppCell	(30)_ILC\|World / shred on Cell_type and subtype	AFF3 TXK SERPINA11 IGF2BP2 SVIL FES	8.01e-06	204	103	6	bd9fbd278c05e396463704d711b60d47699e3c09
ToppCell	facs-Lung-Endomucin-24m-Endothelial-Capillary_Type_1_Cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FRAS1 ADGRV1 OTOGL TENM1 UNC80	2.20e-05	145	103	5	96712c68ab759d7ade0d912581a1a7c25dc6def8
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_with-steroid-Myeloid-Monocytic-Nonclassical_Monocyte-Mono_c4-CD14-CD16\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	AANAT RUSC2 STAB1 FES TAS2R30	2.43e-05	148	103	5	fd0d8386b94adb1bdc993fbb44d2d87852bfd7f0
ToppCell	facs-Lung-24m-Endothelial-capillary_endothelial-capillary_endothelial_cell-capillary_type_1_endothelial_cell\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	FRAS1 ADGRV1 OTOGL TENM1 UNC80	3.75e-05	162	103	5	bf886e22ff2a20353499004b53f25fb9e6574896
ToppCell	3'_v3-GI_small-bowel-Lymphocytic_Invariant-Inducer-like-ILC3\|GI_small-bowel / Manually curated celltypes from each tissue	AFF3 IGF2BP2 SVIL FES LRATD2	4.21e-05	166	103	5	773673a5d0430640439845b264740bfbbdad0cb2
ToppCell	3'_v3-GI_small-bowel-Lymphocytic_Invariant-Inducer-like\|GI_small-bowel / Manually curated celltypes from each tissue	AFF3 IGF2BP2 SVIL FES LRATD2	4.33e-05	167	103	5	3ae46c6363da76c8e1f5579e6027bf88ed637a44
ToppCell	Control-Lymphoid-ILC_B\|Lymphoid / Disease state, Lineage and Cell class	AFF3 SERPINA11 IGF2BP2 SVIL FES	4.46e-05	168	103	5	d7118d39253ed9790908b850088ebfc5a86f4065
ToppCell	Healthy/Control-NK_CD56bright\|World / Disease group and Cell class	CBLB ULBP3 TXK RANBP17 CELSR1	4.85e-05	171	103	5	79d7efefdae267905af05f3001514b8b6934d86e
ToppCell	Severe-B_naive-8\|Severe / disease group and sub_cluster of B and Plasma cells(res = 0.5)	AFF3 FCRLA CBLB NKAIN4 CD37	5.26e-05	174	103	5	f3f8c924420f46321bd47e2b97f18c7241541599
ToppCell	facs-Marrow-B-cells-24m\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FRAS1 FCRLA ADGRV1 CD37 UNC80	5.41e-05	175	103	5	887e75fc90e59a6394d62f3c048a9cfdf6707725
ToppCell	10x_3'_v2v3-Non-neoplastic-Myeloid-Mono-Mono_anti-infl-B\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	STAB1 FUCA1 HS3ST2 FAM20A CTSZ	5.71e-05	177	103	5	382f0d6bbff01e84b0c7840e74ac865864e6da89
ToppCell	facs-SCAT-Fat-3m-Lymphocytic-CD8-positive,_alpha-beta_T_cell\|SCAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	F2RL1 TXK CELSR1 CD37 TENM1	5.71e-05	177	103	5	ffc4c675b25ffe8bd3441ce26dd0984fef4b3b88
ToppCell	Mid-temporal_gyrus_(MTG)\|World / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SLC22A24 NKAIN2 SLC22A9 OTOGL SLC22A10	5.86e-05	178	103	5	ad187db4c40b9078d54dd915c143e0172b2f47b8
ToppCell	5'-Adult-LargeIntestine-Hematopoietic-T_cells-MAIT_cell\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ERN1 TRGV8 CBLB TXK METTL24	5.86e-05	178	103	5	f52f837e948deb6a2d031325f49891bca8d375da
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_5-Exc_L4-5_RORB_HNRNPA1P46\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SLC22A24 NKAIN2 SLC22A10 SORCS2 HS3ST2	6.02e-05	179	103	5	53e700494d251ec5649b2dea5fc7d5aeeeed572b
ToppCell	Children_(3_yrs)-Epithelial-club_cell-D046\|Children_(3_yrs) / Lineage, Cell type, age group and donor	FRAS1 ADGRV1 ERN2 CELSR1 SORCS2	6.18e-05	180	103	5	b509c7d6bdfba672065fb722874bdc68de72ba1c
ToppCell	HSPCs-Neutro_prog.\|HSPCs / Lineage and Cell class	MGAM STAB1 CD37 TMX4 FES	6.18e-05	180	103	5	328192f4678dcdc01c806362b225e770d23498d6
ToppCell	Severe-Lymphoid-T-innate_T\|Severe / Condition, Lineage, Cell class and cell subclass	ERN1 TRGV8 CBLB TXK METTL24	6.34e-05	181	103	5	50ab8562552339d97e4f19aa6ae49fd797da492e
ToppCell	facs-Marrow-Granulocytes-3m-Myeloid-granulocytopoietic_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	AOAH PIK3CB TMX4 TOP2A ADPGK	6.34e-05	181	103	5	566249e04dd491e6287ad2101b7b1ab11031ed8b
ToppCell	facs-Marrow-Granulocytes-3m-Myeloid-granulocytopoietic_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	AOAH PIK3CB TMX4 TOP2A ADPGK	6.34e-05	181	103	5	db9528dc7cb0230e4c36cb27da69102c588c7ee9
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_5\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SLC22A24 NKAIN2 SLC22A9 SLC22A10 HS3ST2	6.51e-05	182	103	5	fa16e194f04250149c82e86551270b244cbc8af4
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_5\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SLC22A24 NKAIN2 SLC22A9 SLC22A10 HS3ST2	6.68e-05	183	103	5	274076a0978bce2bd53a1732045f18ef0f2d9985
ToppCell	IPF-Lymphoid-ILC_B\|Lymphoid / Disease state, Lineage and Cell class	AFF3 TXK METTL24 SVIL FES	6.68e-05	183	103	5	9b507547e6adf78e46e7f542cd9958224ec5826a
ToppCell	droplet-Lung-21m-Hematologic-lymphocytic-Zbtb32+_B_cell\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CACNA1E FRAS1 FCRLA CD37 CTSZ	7.04e-05	185	103	5	5fd4a3776259c96cf2dcb87f050af8226acbbda9
ToppCell	droplet-Lung-21m-Hematologic-lymphocytic-Zbtb32+_B_cell-Zbtb32+_B_cell\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CACNA1E FRAS1 FCRLA CD37 CTSZ	7.04e-05	185	103	5	4c55fa96877ab9a00fcbec3fb70fd2208d222527
ToppCell	LA-03._Atrial_Cardiomyocyte\|World / Chamber and Cluster_Paper	CACNA1E CLTCL1 AFF3 NKAIN2 SVIL	7.59e-05	188	103	5	6d249fe92d51a19da19ec14bb2262d394255d577
ToppCell	droplet-Limb_Muscle-nan-18m-Macroglial-Schwann_cell\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LRRC4 NKAIN2 NKAIN4 CLVS2 UNC80	7.59e-05	188	103	5	8385fd384fc55e3b17802bb6698eb93b2c16d7f2
ToppCell	droplet-Limb_Muscle-nan-18m-Macroglial\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LRRC4 NKAIN2 NKAIN4 CLVS2 UNC80	7.59e-05	188	103	5	cb9d0b48e2fd9cc576132803273b9c0382900944
ToppCell	5'-Adult-SmallIntestine-Hematopoietic-T_cells-gdT\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	AOAH TRGV8 CBLB TXK DZIP3	7.78e-05	189	103	5	5c85656f555d91ecc9540faa67717694a4aef92f
ToppCell	10x_3'_v2v3-Non-neoplastic-Myeloid-Mono-Mono_anti-infl-A\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	WFS1 STAB1 STRN PIK3CB ADPGK	7.98e-05	190	103	5	63018acb7ad80415e861643162abdc2e55968ee4
ToppCell	Control-B_intermediate-14\|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)	AFF3 FCRLA CBLB CD37 CTSZ	8.18e-05	191	103	5	33fce8e086601e636e8c6ef2ab58fcfdd52af369
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	AFF3 CBLB PTGS2 PIEZO2 METTL24	8.18e-05	191	103	5	1caf726bd07fdca389e678fc16304a6ef1790423
ToppCell	Children_(3_yrs)-Epithelial\|Children_(3_yrs) / Lineage, Cell type, age group and donor	AFF3 ADGRV1 RANBP17 CELSR1 SORCS2	8.18e-05	191	103	5	e432c6e1ae82dddf84314ce73d2b7a991630d905
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	AFF3 CBLB PTGS2 PIEZO2 METTL24	8.18e-05	191	103	5	3d60c46bced2984c27a1fcf2910bc38b31fb0148
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Mesenchymal\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	AFF3 CBLB PTGS2 PIEZO2 METTL24	8.38e-05	192	103	5	4022f208eb5db760abd0aac782a25e8ab63efc64
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	FRAS1 TMTC2 SORCS2 FUCA1 FAM20A	8.38e-05	192	103	5	9e031bf93eb8757fdd0cc22f01b44e48f85532d5
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Degenerative_Outer_Medullary_Collecting_Duct_Principal_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	FRAS1 TMTC2 SORCS2 FUCA1 FAM20A	8.38e-05	192	103	5	3d777d07878269b87ec7e1f06489cae7c989d633
ToppCell	Adult-Epithelial\|Adult / Lineage, Cell type, age group and donor	AFF3 TMTC2 ADGRV1 RANBP17 CELSR1	8.38e-05	192	103	5	efb962a5fd3b9bdfd8cf8d13c435e29c8271713e
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	AFF3 CBLB PTGS2 PIEZO2 METTL24	8.38e-05	192	103	5	9333aba0d04203ccccad78d82bf6359922f810a7
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST-Inh_L3-5_SST_MAFB\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	TMTC2 RANBP17 PIEZO2 TENM1 FAM20A	8.59e-05	193	103	5	c7e9e6e4bf5e07c9cbdf1aa7c8828f4b2500e3ff
ToppCell	Control-NK_CD56bright\|Control / Disease condition and Cell class	OGFRL1 AFF3 TXK CELSR1 FES	8.59e-05	193	103	5	8b1e7a226a6057e1097c1525984127b54e823876
ToppCell	3'-Child09-12-SmallIntestine-Hematopoietic-Myeloid-LYVE1+_Macrophage\|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	OGFRL1 PTGS2 STAB1 FUCA1 CTSZ	8.80e-05	194	103	5	8e2819a9d0529f7b2de1a7c1190575175d6173ee
ToppCell	Adult-Immune-interstitial_macrophage_(C1Q_positive)-D231\|Adult / Lineage, Cell type, age group and donor	AOAH STAB1 FES FUCA1 CTSZ	8.80e-05	194	103	5	800d3d7a9e864d2d6a100a4e4af22f45d5790a8d
ToppCell	ILEUM-inflamed-(6)_ILC\|inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	AFF3 TXK SERPINA11 SVIL FES	8.80e-05	194	103	5	4d51d49366c34ff1241770b4acc0167a43b3155a
ToppCell	5'-Adult-LargeIntestine-Hematopoietic-T_cells-TRGV2_gdT\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	AOAH TRGV8 CBLB TXK METTL24	8.80e-05	194	103	5	4b208bb429a1e3d58a9b757b05ef4df85a1e7f1e
ToppCell	(0)_NK/T_cells-(0)_NK_T_CD8_Cytotoxic\|(0)_NK/T_cells / Oesophagus cell shreds on cell class (v1) and cell subclass (v1)	AFF3 PTGS2 TXK SERPINA11 FES	9.01e-05	195	103	5	13717c6e42882162445bc1b1445d66efcb68e19d
ToppCell	facs-Brain_Non-Myeloid-Cortex-3m-Neuronal\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1E FRAS1 SLC7A4 CLVS2 UNC80	9.01e-05	195	103	5	ffbab350e67d9c4b66c0ab84550daec8b8139a27
ToppCell	10x5'v1-week_14-16-Lymphocytic_B-B_lineage-immature_B_cell\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	AFF3 FCRLA CBLB NKAIN4 CD37	9.01e-05	195	103	5	ecaaa3d071e763c40d05d088fbf9e8ca06f78f47
ToppCell	ILEUM-inflamed-(6)_ILC3\|inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	AFF3 TXK SERPINA11 SVIL FES	9.01e-05	195	103	5	c6968da7d2b60c2163e1ff0ffa41340e1ec1d2ed
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-Mono-Mono_anti-infl\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	AOAH STAB1 FES FUCA1 CTSZ	9.01e-05	195	103	5	0ec1b572bbb92b6da3440139366a4c1743b1ad92
ToppCell	normal_Lymph_Node-Myeloid_cells-CD1c+_DCs\|normal_Lymph_Node / Location, Cell class and cell subclass	OGFRL1 AOAH PTGS2 FES CTSZ	9.01e-05	195	103	5	cd4d61a463e0e87b711e08ceedee5bef5d735e64
ToppCell	10x_3'_v2v3-Non-neoplastic-Myeloid-TAM-BDM-TAM-BDM_INF\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	AOAH STAB1 CD37 FUCA1 FAM20A	9.23e-05	196	103	5	efdc95811e8b17243065ae82d748ea2c5775fdbc
ToppCell	10x_3'_v2v3-Non-neoplastic-Myeloid-TAM-BDM-TAM-BDM_INF-Z\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	AOAH STAB1 CD37 FUCA1 FAM20A	9.23e-05	196	103	5	3392efa5007736b1e87f34805c16e8baa792e596
ToppCell	10x5'-GI_small-bowel-Lymphocytic_T_CD4/8-lo-Trm_Tgd\|GI_small-bowel / Manually curated celltypes from each tissue	AOAH TRGV8 CBLB TXK FES	9.23e-05	196	103	5	5755ca4abcae3717894bbf7cbd49bca0a3a03067
ToppCell	ILEUM-inflamed-(3)_Resident_macrophages\|inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	AOAH PTGS2 STAB1 FUCA1 CTSZ	9.23e-05	196	103	5	5ac246a823a8e1996325753858615269687b429d
ToppCell	5'-GW_trimst-2-SmallIntestine-Hematopoietic-T_cells-TRDV2/TRGV9_gdT\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ERN1 TRGV1 TRGV8 TXK CD37	9.23e-05	196	103	5	8e20ffe39157619b1d02b48d2cf9d62f26bdb3e8
ToppCell	10x5'-GI_small-bowel-Lymphocytic_T_CD4/8-lo\|GI_small-bowel / Manually curated celltypes from each tissue	AOAH TRGV8 CBLB TXK FES	9.23e-05	196	103	5	181f3c1af565355b29f20ca6074147c313ca3477
ToppCell	ILEUM-non-inflamed-(6)_ILC\|non-inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	AFF3 PTGS2 TXK SERPINA11 SVIL	9.46e-05	197	103	5	76a233eb9611d24b9bb9f4359c26606332a3c29e
ToppCell	3'-GW_trimst-2-LargeIntestine-Hematopoietic-Myeloid\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	OGFRL1 AOAH STAB1 FAM20A CTSZ	9.46e-05	197	103	5	67bf15ee83938bd40f6ecd5abaaf90ad95096d21
ToppCell	5'-GW_trimst-1.5-SmallIntestine-Hematopoietic-Myeloid-LYVE1+_Macrophage\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	OGFRL1 AOAH STAB1 CD37 FAM20A	9.46e-05	197	103	5	1c0024049db2d2c817a7f503de235b9630b24e33
ToppCell	PCW_10-12-Mesenchymal-Mesenchymal_fibroblastic-mes_immature1_(0)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	AFF3 TMTC2 CBLB NKAIN2 PIEZO2	9.46e-05	197	103	5	11a4c417f035e554431a8f03be13b5eefa3530c0
ToppCell	10x_3'_v2v3-Non-neoplastic-Myeloid-Mono-Mono_anti-infl-G\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	STAB1 FUCA1 HS3ST2 FAM20A CTSZ	9.69e-05	198	103	5	eb0a94c426a7c567f94490b848e28784587c6dcd
ToppCell	Bronchial-NucSeq-Epithelial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	TMTC2 ADGRV1 RANBP17 CELSR1 FAM20A	9.92e-05	199	103	5	5f7da3eab58ace6cddb3179a415cd839d5767958
ToppCell	PBMC_fresh-frozen-Severe-critical_convalescent_d42-56-Myeloid-Monocytic-Classical_Monocyte-Mono_c2-CD14-HLA-DPB1\|Severe-critical_convalescent_d42-56 / Compartment, severity and other cell annotations on 10x 3' data (130k)	OGFRL1 AOAH STAB1 FES CTSZ	9.92e-05	199	103	5	4fc03377c017209111561789226621d258291481
ToppCell	Bronchial-NucSeq-Epithelial-Epi_alveolar\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	AFF3 TMTC2 ADGRV1 RANBP17 FAM20A	9.92e-05	199	103	5	725610310e5c5fd7120c0be9acb55bf152026ddd
ToppCell	Parenchymal-NucSeq-Epithelial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	TMTC2 ADGRV1 RANBP17 CELSR1 FAM20A	9.92e-05	199	103	5	5cea0d9e261903e0eaad60c28a07dff72ce65027
ToppCell	Transverse-T_cell-gd_T\|Transverse / Region, Cell class and subclass	AOAH CBLB TXK DZIP3 FUCA1	9.92e-05	199	103	5	92554fddd887fe6c1c943ed704d4a02c999ba830
Drug	Fenofibrate [49562-28-9]; Down 200; 11uM; MCF7; HT_HG-U133A	OGFRL1 SPPL2B ERN2 F2RL1 TAF6L STRN PIK3CB CSTF3	2.21e-06	195	99	8	7432_DN
Disease	estrogen measurement	SLC22A24 SLC22A9 SLC22A10	4.19e-06	10	98	3	EFO_0011007
Disease	Seizures	CACNA1E AFF3 PTGS2 FDFT1 ALAD FUCA1	9.08e-05	218	98	6	C0036572
Disease	executive function measurement	SFMBT1 NKAIN2 GPR139 STAB1 PIEZO2 ASB3 FBXO33	2.64e-04	376	98	7	EFO_0009332
Disease	Premature Birth	OGG1 PTGS2	5.89e-04	11	98	2	C0151526
Disease	acute myeloid leukemia (implicated_via_orthology)	SF3B1 TOP2A	7.05e-04	12	98	2	DOID:9119 (implicated_via_orthology)
Disease	renal cell carcinoma (biomarker_via_orthology)	OGG1 PTGS2	9.68e-04	14	98	2	DOID:4450 (biomarker_via_orthology)
Disease	urate measurement, bone density	ATG9B FRAS1 AHCTF1 AOAH RANBP17 STRN ASB3 DHX35	1.08e-03	619	98	8	EFO_0003923, EFO_0004531
Disease	phosphatidylcholine 38:6 measurement	AHCTF1 DEPDC5	1.27e-03	16	98	2	EFO_0010388
Disease	Conventional (Clear Cell) Renal Cell Carcinoma	ERN1 OGG1 PTGS2 ALAD	1.52e-03	148	98	4	C0279702
Disease	reticulocyte count	AANAT F2RL1 STRN FDFT1 ASB3 DZIP3 DEPDC5 ALAD FUCA1 PAQR3	2.49e-03	1045	98	10	EFO_0007986
Disease	Nonsyndromic Deafness	TMTC2 ADGRV1 OTOGL	2.51e-03	81	98	3	C3711374
Disease	Leukemia, Myelocytic, Acute	CBLB SF3B1 SVIL CTSZ	2.69e-03	173	98	4	C0023467
Disease	alcohol consumption measurement	CACNA1E MGAM AFF3 ADGRV1 GPR139 RANBP17 ASB3 CSTF3 FBXO33 HS3ST2 XPO7	2.77e-03	1242	98	11	EFO_0007878
Disease	pallidum volume change measurement, age at assessment	NKAIN2 SORCS2	3.12e-03	25	98	2	EFO_0008007, EFO_0021494
Disease	hepatocellular carcinoma (is_implicated_in)	ERN1 PTGS2 SF3B1 FES	3.16e-03	181	98	4	DOID:684 (is_implicated_in)

Protein segments in the cluster

Peptide	Gene	Start	Entry
EHLVQYSQQGLHWLR	AFF3	1206	P51826
LENAFQIGGHPWHYI	DCAF17	291	Q5H9S7
YHILATVDGHWANQL	ADPGK	386	Q9BRR6
EVNGKPHHILYIWQG	AVIL	431	O75366
IVGDWYFHHQEQPLQ	CNPY4	166	Q8N129
NQVHHLGWLLLEEYQ	EIF2D	551	P41214
NDLSVWDYAHQHGIP	CTSZ	136	Q9UBR2
GIWINLGPLLYHFEN	CARNMT1	336	Q8N4J0
VHHNQPQWLTHLLYY	CACNA1E	496	Q15878
QRFHVQNLGHPYWLT	ALG9	336	Q9H6U8
LHWYPQQINGHKFEG	ADGRV1	5751	Q8WXG9
LAYLEQLHGQHEAWL	DGUOK	216	Q16854
AYQLLGHVLQHESWQ	CELSR1	2156	Q9NYQ6
LVFGNSTLHLPHWGY	SLC7A4	496	O43246
PSGLSWHEQILYFLN	ATG2B	1206	Q96BY7
LQHWEFAPNSVHYLL	RANBP17	366	Q9H2T7
QLNYLGSSHQIWHIL	PAQR3	266	Q6TCH7
GTFLWDNLHNRYHPL	AOAH	421	P28039
SYLQQYPHQLLCTWH	MFRP	316	Q9BY79
GANPAYHELLLTVLW	RELCH	956	Q9P260
SRLGDDYNIPHWINH	DEPDC5	391	O75140
HLESWLQYFPLAQIH	HS3ST2	256	Q9Y278
FPSLELGHWLYQTEL	TOR1AIP2	16	Q9H496
LEHNHTYIQWLFPLR	OGFRL1	151	Q5TC84
QFRVYLGLPLGNHWS	FRAS1	3001	Q86XX4
VLHSGYFHPLLRAWQ	ALAD	6	P13716
GEMLYLPALWFHHVQ	JMJD7	266	P0C870
EGQSEGSYLLHHLPW	SLC66A1	241	Q6ZP29
GVYTWHQDGLRQLPH	ERN2	231	Q76MJ5
HINLHVRGGYILPWQ	MGAM	1706	O43451
ILRNWNFLAVTHPGY	CBLB	246	Q13191
LLAIHGYTVWAHNLI	FBXO33	461	Q7Z6M2
LLHNFHSFLYQPDWR	FDFT1	96	P37268
WLHAFLKRNPGNHLY	IFNAR1	261	P17181
EQCLLVLGHHPDIWY	CSTF3	281	Q12996
YAIFLHWPENGVLNL	FUCA1	396	P04066
GYQWAPILANFVHII	NKAIN2	31	Q5VXU1
HHTWNAILLPFVYLT	LRRC4	11	Q9HBW1
EFNTLYHWHPLLPDT	PTGS2	366	P35354
PHWAVYVGNFQVVHL	LRATD2	131	Q96KN1
PHLQWEVLDGLLAQY	IGF2BP2	91	Q9Y6M1
LTFHLPYCGPNWIQH	OR10G8	161	Q8NGN5
QLDVTLAQLYHHWGS	OGG1	101	O15527
NIAEHLLQYWPFGEL	NPBWR2	101	P48146
VLESYYNHLWTNHPL	DZIP3	431	Q86Y13
LYLFLQHCFGHWPLD	SMPD4	416	Q9NXE4
IWFPLKIAYHIHGNN	F2RL1	126	P55085
IHVPQVQYHGNIFFW	EFCAB5	1076	A4FU69
LGPWNHIYEFVNHAI	ASB3	371	Q9Y575
RNYWLLIGHHETPLS	ERN1	356	O75460
FHLIVSYDWLILQGP	FCRLA	71	Q7L513
WLLELAPHFYQQGTH	DHX35	676	Q9H5Z1
PLVLAWQVLHVFYSH	ATG9B	451	Q674R7
YAQVVLWFSHSGLLP	AHCTF1	666	Q8WYP5
HLYGAPIQNRWLVHI	GPR139	251	Q6DWJ6
PYWHCRLLFQLAQLH	MAU2	141	Q9Y6X3
HYPQDWFQVLILRGN	CD37	156	P11049
HHQGLWIPGYSAFEL	OTOGL	1311	Q3ZCN5
VQKPLHEQLWYHGAI	FES	451	P07332
GQLIFEIHLHWPGFE	METTL24	291	Q5JXM2
YNHEDIIQTHYQPWG	RUSC2	1126	Q8N2Y8
VLLLHWYATQLNPAF	TAS2R30	61	P59541
WTHGDLVSGLYQHIL	TAF6L	276	Q9Y6J9
QYSLPGILHFLQHEW	STRN	46	O43815
GPILLWRYLHHLGSQ	AANAT	136	Q16613
IHWYLHQEGKAPQCL	TRGV1	51	A0A0A0MS02
LFLVDNHHEVYLWQG	SVIL	2046	O95425
FIHPQWQLLHLNGTF	SLC22A24	91	Q8N4F4
LIYVAVNPHLHLEWN	LMBRD2	166	Q68DH5
LAFGLLWAPYHAVNL	LTB4R2	231	Q9NPC1
FVHPQWQLLHLNGTF	SLC22A9	91	Q8IVM8
FVHPQWQLLHLNGTI	SLC22A10	91	Q63ZE4
GALLSADLYFHLWPQ	FAM20A	16	Q96MK3
LHLHLRWADNPYVSG	SORCS2	501	Q96PQ0
AFHLELFLLPHYPNW	TMEM69	196	Q5SWH9
LFWRFQITIHHPIYL	TENM1	416	Q9UKZ4
GQFLFWHLRSEVHIP	PIK3CB	671	P42338
VHTHLLNPEWLVNYF	CLTC	641	Q00610
VHTHLLNPEWLVNFF	CLTCL1	641	P53675
LGNHPNSAIILHYAW	CNOT1	511	A5YKK6
GGIHFVNQPWYIHAL	CLVS2	196	Q5SYC1
GYQWAPILANFVHII	NKAIN4	31	Q8IVV8
WLQFIIHSQLHNYHP	SPG11	1371	Q96JI7
YNFTIIHLPRHGQQW	ULBP3	36	Q9BZM4
WHLHNYFTVTLGIPA	TMX4	171	Q9H1E5
LGLLVFPYTHQNWEV	YIF1A	106	O95070
FNHLFSLSGYQWILP	UNC80	2221	Q8N2C7
HAHFNRPFLLLLWEV	SERPINA11	391	Q86U17
DSLNHLLNYVWPNVF	SF3B1	1206	O75533
GLNPWSYHLVNVLLH	TMTC2	81	Q8N394
ILYNPQWAHLPHDLS	SPPL2B	46	Q8TCT7
VNPDLSWYHHANPIL	PIEZO2	326	Q9H5I5
HLIHFWNVLLEAGYD	TTC41P	761	Q6P2S7
LLGPAHWIVFYNHSG	STAB1	1211	Q9NY15
HWIVFYNHSGQPEVN	STAB1	1216	Q9NY15
GLLINFIHHNWPSLL	TOP2A	551	P11388
LYALGLHNFVSPNWL	ZSWIM8	1286	A7E2V4
FQSIPELIWYHQHNA	TXK	221	P42681
EFAPNSVHYLLSLWQ	XPO7	371	Q9UIA9
THWYLHQEGKAPQRL	TRGV8	51	A0A0C4DH27
YLDPFLHHVGWAAQQ	SFMBT1	211	Q9UHJ3
LFQLDPVNRTHLGWY	VSIG10L2	201	P0DP72
LHHWIDLTFGYKLQG	WDR81	541	Q562E7
NFGWNHLEPYAHFLL	WFS1	396	O76024